USHBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)6.18869283
2vascular endothelial growth factor signaling pathway (GO:0038084)5.66360963
3behavioral response to nicotine (GO:0035095)5.37861597
4DNA deamination (GO:0045006)4.95564702
5fatty acid transmembrane transport (GO:1902001)4.81937472
6endothelium development (GO:0003158)4.75878159
7sarcomere organization (GO:0045214)4.66251191
8heart trabecula formation (GO:0060347)4.61313977
9cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.56567421
10cardiac myofibril assembly (GO:0055003)4.52775083
11carnitine shuttle (GO:0006853)4.47164227
12regulation of sequestering of triglyceride (GO:0010889)4.39541165
13L-fucose catabolic process (GO:0042355)4.28140738
14fucose catabolic process (GO:0019317)4.28140738
15L-fucose metabolic process (GO:0042354)4.28140738
16retina vasculature morphogenesis in camera-type eye (GO:0061299)4.24102593
17surfactant homeostasis (GO:0043129)4.20731714
18lymphangiogenesis (GO:0001946)4.06319622
19transcytosis (GO:0045056)4.02153075
20myofibril assembly (GO:0030239)4.01615777
21bundle of His cell to Purkinje myocyte communication (GO:0086069)4.00217318
22indole-containing compound catabolic process (GO:0042436)3.99292098
23indolalkylamine catabolic process (GO:0046218)3.99292098
24tryptophan catabolic process (GO:0006569)3.99292098
25response to pheromone (GO:0019236)3.96086263
26positive regulation of vasculogenesis (GO:2001214)3.92070912
27plasma membrane repair (GO:0001778)3.90498091
28kynurenine metabolic process (GO:0070189)3.83497809
29platelet dense granule organization (GO:0060155)3.83488810
30tricarboxylic acid cycle (GO:0006099)3.81012453
31negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.79794759
32indolalkylamine metabolic process (GO:0006586)3.73639304
33regulation of endothelial cell differentiation (GO:0045601)3.73633603
34ovulation from ovarian follicle (GO:0001542)3.68900586
35fatty acid beta-oxidation (GO:0006635)3.68130040
36low-density lipoprotein particle clearance (GO:0034383)3.57096521
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.52472927
38regulation of vasculogenesis (GO:2001212)3.51991401
39actin-myosin filament sliding (GO:0033275)3.50530352
40muscle filament sliding (GO:0030049)3.50530352
41water-soluble vitamin biosynthetic process (GO:0042364)3.49535428
42detection of light stimulus involved in sensory perception (GO:0050962)3.48392224
43detection of light stimulus involved in visual perception (GO:0050908)3.48392224
44blood vessel maturation (GO:0001955)3.46057753
45tryptophan metabolic process (GO:0006568)3.45093351
46regulation of actin filament-based movement (GO:1903115)3.43887664
47regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.43663534
482-oxoglutarate metabolic process (GO:0006103)3.42060122
49lysine catabolic process (GO:0006554)3.41775730
50lysine metabolic process (GO:0006553)3.41775730
51chemical homeostasis within a tissue (GO:0048875)3.41505308
52negative regulation of telomere maintenance (GO:0032205)3.40733653
53ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.40273509
54cellular ketone body metabolic process (GO:0046950)3.39752049
55carnitine transmembrane transport (GO:1902603)3.39514193
56cytidine metabolic process (GO:0046087)3.39496128
57cytidine catabolic process (GO:0006216)3.39496128
58cytidine deamination (GO:0009972)3.39496128
59venous blood vessel morphogenesis (GO:0048845)3.39176639
60endothelial tube morphogenesis (GO:0061154)3.39082118
61morphogenesis of an endothelium (GO:0003159)3.39082118
62vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.38443741
63epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.37174545
64endothelial cell morphogenesis (GO:0001886)3.36369724
65negative regulation of potassium ion transmembrane transport (GO:1901380)3.36335651
66glomerular filtration (GO:0003094)3.32402671
67blood vessel endothelial cell migration (GO:0043534)3.31752917
68cardiac muscle tissue morphogenesis (GO:0055008)3.29118414
69cell migration involved in sprouting angiogenesis (GO:0002042)3.27610853
70piRNA metabolic process (GO:0034587)3.26737589
71cardiac muscle cell development (GO:0055013)3.26571871
72sulfation (GO:0051923)3.25687051
73cardiac muscle contraction (GO:0060048)3.24952628
74regulation of fatty acid oxidation (GO:0046320)3.24160325
75fatty acid oxidation (GO:0019395)3.21723859
76carnitine transport (GO:0015879)3.21387542
77amino-acid betaine transport (GO:0015838)3.21387542
78regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.17507840
79negative regulation of mast cell activation (GO:0033004)3.15625292
80positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.15261912
81lipid oxidation (GO:0034440)3.14755303
82regulation of skeletal muscle contraction (GO:0014819)3.14102590
83regulation of sarcomere organization (GO:0060297)3.13688222
84kidney morphogenesis (GO:0060993)3.13207194
85cardiac cell development (GO:0055006)3.13149185
86fatty acid catabolic process (GO:0009062)3.12839677
87positive regulation of fatty acid oxidation (GO:0046321)3.12501104
88ventricular cardiac muscle cell action potential (GO:0086005)3.10586257
89respiratory chain complex IV assembly (GO:0008535)3.09701269
90renal filtration (GO:0097205)3.08946623
91protein complex biogenesis (GO:0070271)3.05605005
92actomyosin structure organization (GO:0031032)3.04926951
93patterning of blood vessels (GO:0001569)3.04715446
94ketone body metabolic process (GO:1902224)3.04265256
95regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.03803028
96regulation of cholesterol storage (GO:0010885)3.03467782
97axoneme assembly (GO:0035082)3.01679252
98biotin metabolic process (GO:0006768)3.00365562
99valine metabolic process (GO:0006573)2.99751193
100positive regulation of fatty acid transport (GO:2000193)2.98327826
101muscle tissue morphogenesis (GO:0060415)2.98056631
102pyrimidine ribonucleoside catabolic process (GO:0046133)2.97686650
103cardiac muscle hypertrophy (GO:0003300)2.96759704
104regulation of relaxation of muscle (GO:1901077)2.96585653
105preassembly of GPI anchor in ER membrane (GO:0016254)2.95040938
106actin-mediated cell contraction (GO:0070252)2.92704913
107endothelial cell differentiation (GO:0045446)2.92165049
108basement membrane organization (GO:0071711)2.91700611
109adult heart development (GO:0007512)2.91490241
110mitochondrial respiratory chain complex I assembly (GO:0032981)2.91285701
111NADH dehydrogenase complex assembly (GO:0010257)2.91285701
112mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91285701
113positive regulation of fatty acid beta-oxidation (GO:0032000)2.90826940
114trabecula formation (GO:0060343)2.89035465
115regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.88474182
116positive regulation of defense response to virus by host (GO:0002230)2.88028863
117acetyl-CoA metabolic process (GO:0006084)2.87590706
118regulation of the force of heart contraction (GO:0002026)2.87520353
119negative regulation of blood vessel endothelial cell migration (GO:0043537)2.87125507
120cytochrome complex assembly (GO:0017004)2.85223939
121regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.84042822
122negative regulation of nitric-oxide synthase activity (GO:0051001)2.83888317
123regulation of action potential (GO:0098900)2.83302006
124striated muscle hypertrophy (GO:0014897)2.82642569
125indole-containing compound metabolic process (GO:0042430)2.81563235
126NADH metabolic process (GO:0006734)2.79557015
127aspartate family amino acid catabolic process (GO:0009068)2.78982661
128cellular response to ATP (GO:0071318)2.78092986
129neuronal action potential (GO:0019228)2.76393984
130positive regulation of lipid storage (GO:0010884)2.75605451
131negative regulation of endothelial cell migration (GO:0010596)2.75571262
132regulation of rhodopsin mediated signaling pathway (GO:0022400)2.74746654
133auditory receptor cell stereocilium organization (GO:0060088)2.74734855
134regulation of triglyceride catabolic process (GO:0010896)2.74547891
135protein-cofactor linkage (GO:0018065)2.74491980
136regulation of cardioblast differentiation (GO:0051890)2.73735042
137regulation of p38MAPK cascade (GO:1900744)2.73650941
138vasculogenesis (GO:0001570)2.73383832
139mitochondrial respiratory chain complex assembly (GO:0033108)2.73281649
140fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.73002821
141adaptation of signaling pathway (GO:0023058)2.72228561
142negative regulation of cytosolic calcium ion concentration (GO:0051481)2.71813078
143protein polyglutamylation (GO:0018095)2.71613601
144monocarboxylic acid catabolic process (GO:0072329)2.70453621
145regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.70424046
146rhodopsin mediated signaling pathway (GO:0016056)2.70391600
147response to mercury ion (GO:0046689)2.69843382
148regulation of nuclear cell cycle DNA replication (GO:0033262)2.69727937
149negative regulation of Rho protein signal transduction (GO:0035024)2.69681752
150brown fat cell differentiation (GO:0050873)2.69300724
151mannosylation (GO:0097502)2.69080728
152phospholipid homeostasis (GO:0055091)2.69061902
153positive regulation of prostaglandin secretion (GO:0032308)2.69055382
154cornea development in camera-type eye (GO:0061303)2.68730692
155quaternary ammonium group transport (GO:0015697)2.67446326
156ubiquinone biosynthetic process (GO:0006744)2.67419455
157S-adenosylmethionine metabolic process (GO:0046500)2.67286712
158epithelial cilium movement (GO:0003351)2.66419668
159short-chain fatty acid metabolic process (GO:0046459)2.65880620
160multicellular organism reproduction (GO:0032504)2.65463934
161gamma-aminobutyric acid transport (GO:0015812)2.64607424
162negative regulation of synaptic transmission, GABAergic (GO:0032229)2.62814561
163synaptic transmission, cholinergic (GO:0007271)2.61695666
164amine catabolic process (GO:0009310)2.60864175
165cellular biogenic amine catabolic process (GO:0042402)2.60864175
166retinal cone cell development (GO:0046549)2.60280643
167reflex (GO:0060004)2.60230438
168behavioral response to ethanol (GO:0048149)2.57974328
169DNA methylation involved in gamete generation (GO:0043046)2.54843771
170regulation of cilium movement (GO:0003352)2.54525312
171regulation of glucokinase activity (GO:0033131)2.53257697
172regulation of hexokinase activity (GO:1903299)2.53257697
173phosphatidylinositol acyl-chain remodeling (GO:0036149)2.51870639
174reciprocal meiotic recombination (GO:0007131)2.51804566
175reciprocal DNA recombination (GO:0035825)2.51804566
176positive regulation of icosanoid secretion (GO:0032305)2.51481366
177rRNA catabolic process (GO:0016075)2.49679384
178cAMP catabolic process (GO:0006198)2.48536329
179cilium morphogenesis (GO:0060271)2.47607543
180G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47546228
181signal peptide processing (GO:0006465)2.47275787
182L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.46576661
183neural tube formation (GO:0001841)2.46127639
184RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.45759234
185endoderm formation (GO:0001706)2.45694176
186photoreceptor cell development (GO:0042461)2.44539342
187nephron tubule morphogenesis (GO:0072078)2.42325274
188nephron epithelium morphogenesis (GO:0072088)2.42325274
189ubiquinone metabolic process (GO:0006743)2.42094804
190primary amino compound metabolic process (GO:1901160)2.40790830
191GPI anchor metabolic process (GO:0006505)2.40671449
192photoreceptor cell maintenance (GO:0045494)2.40282769
193exogenous drug catabolic process (GO:0042738)2.39563206
194nonmotile primary cilium assembly (GO:0035058)2.39325832
195mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.38478580
196regulation of memory T cell differentiation (GO:0043380)2.37101475
197benzene-containing compound metabolic process (GO:0042537)2.36435591
198dopamine transport (GO:0015872)2.35792005
199somite development (GO:0061053)2.34928608
200protein localization to cilium (GO:0061512)2.34853753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.40536108
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.94026239
3ZNF274_21170338_ChIP-Seq_K562_Hela3.96103776
4VDR_22108803_ChIP-Seq_LS180_Human3.50947864
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.48584008
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.26378182
7CLOCK_20551151_ChIP-Seq_293T_Human3.19062951
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.16601793
9EZH2_22144423_ChIP-Seq_EOC_Human3.13156589
10PPARA_22158963_ChIP-Seq_LIVER_Mouse3.11914688
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.97574107
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.80901338
13GBX2_23144817_ChIP-Seq_PC3_Human2.79017575
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.76698163
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.75108895
16GATA2_21666600_ChIP-Seq_HMVEC_Human2.71948385
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.70722415
18* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.53594519
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53114889
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.52577349
21IGF1R_20145208_ChIP-Seq_DFB_Human2.50375861
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42592073
23TBX20_22328084_ChIP-Seq_HEART_Mouse2.42455428
24TBX20_22080862_ChIP-Seq_HEART_Mouse2.42455428
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.22883551
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09179951
27GATA1_22025678_ChIP-Seq_K562_Human2.08577714
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06018300
29ZNF263_19887448_ChIP-Seq_K562_Human2.03735264
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02553227
31CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02487875
32TP63_17297297_ChIP-ChIP_HaCaT_Human2.02211243
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97408832
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92287685
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.91812044
36EWS_26573619_Chip-Seq_HEK293_Human1.90718618
37P300_19829295_ChIP-Seq_ESCs_Human1.89796745
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88409082
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.86444766
40ER_23166858_ChIP-Seq_MCF-7_Human1.85269668
41TAF15_26573619_Chip-Seq_HEK293_Human1.84846328
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81063852
43FUS_26573619_Chip-Seq_HEK293_Human1.77786838
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76542942
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76350653
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.72785717
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.71297858
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67586472
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65728286
50TP53_22573176_ChIP-Seq_HFKS_Human1.63428591
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.63013277
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.60876716
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.57271022
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57031932
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56017933
56CBP_20019798_ChIP-Seq_JUKART_Human1.54053888
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54053888
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.53006453
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48049680
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47032750
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46321803
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46028538
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43845181
64GATA1_19941826_ChIP-Seq_K562_Human1.43706341
65NANOG_19829295_ChIP-Seq_ESCs_Human1.42759640
66SOX2_19829295_ChIP-Seq_ESCs_Human1.42759640
67IRF1_19129219_ChIP-ChIP_H3396_Human1.41770870
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41531306
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40824748
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40529128
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39937420
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.39734352
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39734352
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38331279
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36782883
76STAT3_23295773_ChIP-Seq_U87_Human1.36583931
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36029711
78MYC_18940864_ChIP-ChIP_HL60_Human1.35959635
79GATA3_21878914_ChIP-Seq_MCF-7_Human1.35678174
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34104357
81AR_25329375_ChIP-Seq_VCAP_Human1.32977959
82TCF4_23295773_ChIP-Seq_U87_Human1.32732787
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32592322
84REST_21632747_ChIP-Seq_MESCs_Mouse1.30420134
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29430682
86TCF4_22108803_ChIP-Seq_LS180_Human1.29425768
87GABP_17652178_ChIP-ChIP_JURKAT_Human1.28839202
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28672655
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.28525981
90ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28003612
91PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27657200
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27120682
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26904839
94NCOR_22424771_ChIP-Seq_293T_Human1.26739545
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25547646
96AR_20517297_ChIP-Seq_VCAP_Human1.25500414
97SMAD4_21799915_ChIP-Seq_A2780_Human1.25230170
98* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24575112
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.23790752
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23538630
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23362910
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.23241976
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23170158
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23170158
105IRF8_22096565_ChIP-ChIP_GC-B_Human1.21425168
106HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20123110
107HOXB7_26014856_ChIP-Seq_BT474_Human1.19486438
108CJUN_26792858_Chip-Seq_BT549_Human1.18625391
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.18571541
110FOXA2_19822575_ChIP-Seq_HepG2_Human1.17349107
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17212758
112CBX2_27304074_Chip-Seq_ESCs_Mouse1.16552096
113FOXO3_23340844_ChIP-Seq_DLD1_Human1.16366446
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16281839
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15459695
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.15434893
117RUNX2_22187159_ChIP-Seq_PCA_Human1.14422391
118EST1_17652178_ChIP-ChIP_JURKAT_Human1.13507901
119STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12171806
120SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11552335
121E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11285204
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.11094276
123* SMAD4_21741376_ChIP-Seq_EPCs_Human1.10762940
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10691960
125MYC_19829295_ChIP-Seq_ESCs_Human1.10335099
126RNF2_27304074_Chip-Seq_NSC_Mouse1.10005764
127MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08893257
128CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08556580
129STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06961858
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06847321
131SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06132203
132AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06064425
133LXR_22292898_ChIP-Seq_THP-1_Human1.05545322
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.05122691
135CRX_20693478_ChIP-Seq_RETINA_Mouse1.02911068
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02537259
137CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01805803
138PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00734408
139TAF2_19829295_ChIP-Seq_ESCs_Human1.00179470
140CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99814216
141KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99270554
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98878590
143ERA_21632823_ChIP-Seq_H3396_Human0.98687434
144GATA3_26560356_Chip-Seq_TH2_Human0.98658967
145* FOXH1_21741376_ChIP-Seq_EPCs_Human0.97672072
146TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97284125
147* NANOG_20526341_ChIP-Seq_ESCs_Human0.96919144
148AR_21572438_ChIP-Seq_LNCaP_Human0.96863028
149RACK7_27058665_Chip-Seq_MCF-7_Human0.96823202
150RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95723779
151ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92755569
152SOX2_20726797_ChIP-Seq_SW620_Human0.92353464
153CDX2_20551321_ChIP-Seq_CACO-2_Human0.92091166
154GATA2_19941826_ChIP-Seq_K562_Human0.91861063
155STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.89579362
156TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.89452700
157SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88850609
158TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88517478
159KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88296369
160SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87346028
161KDM2B_26808549_Chip-Seq_K562_Human0.86522382
162NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86052508
163CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85957090
164ISL1_27105846_Chip-Seq_CPCs_Mouse0.85589282
165ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83872479
166SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82936119
167DROSHA_22980978_ChIP-Seq_HELA_Human0.82264496
168AHR_22903824_ChIP-Seq_MCF-7_Human0.81368344
169TCF4_18268006_ChIP-ChIP_LS174T_Human0.81208254
170RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79733359
171NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79613724
172NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79538904
173NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79538904
174NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79466969
175WT1_19549856_ChIP-ChIP_CCG9911_Human0.79003498
176* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78277874
177EZH2_18974828_ChIP-Seq_MESCs_Mouse0.78091640
178RNF2_18974828_ChIP-Seq_MESCs_Mouse0.78091640
179HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78080629
180IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.77949788
181MTF2_20144788_ChIP-Seq_MESCs_Mouse0.77424997
182JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76866729
183JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76483044
184PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.76296976
185RUNX1_27514584_Chip-Seq_MCF-7_Human0.75847744
186RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.75430987
187EED_16625203_ChIP-ChIP_MESCs_Mouse0.74985131
188GATA4_21415370_ChIP-Seq_HL-1_Mouse0.74703487
189NFIB_24661679_ChIP-Seq_LUNG_Mouse0.74644236
190WT1_25993318_ChIP-Seq_PODOCYTE_Human0.74476113
191KDM2B_26808549_Chip-Seq_DND41_Human0.73795962
192SMC1_22415368_ChIP-Seq_MEFs_Mouse0.73524610
193BCAT_22108803_ChIP-Seq_LS180_Human0.73460447
194SMAD4_21741376_ChIP-Seq_HESCs_Human0.73080462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.02206217
2MP0002837_dystrophic_cardiac_calcinosis4.25629458
3MP0004084_abnormal_cardiac_muscle4.16642038
4MP0001879_abnormal_lymphatic_vessel4.02566000
5MP0004215_abnormal_myocardial_fiber3.47067581
6MP0005167_abnormal_blood-brain_barrier3.41899503
7MP0000751_myopathy3.11664843
8MP0004036_abnormal_muscle_relaxation2.97743123
9MP0008877_abnormal_DNA_methylation2.96992755
10MP0005670_abnormal_white_adipose2.93843065
11MP0004272_abnormal_basement_membrane2.82908140
12MP0003195_calcinosis2.81434001
13MP0003646_muscle_fatigue2.76377168
14MP0003828_pulmonary_edema2.76166776
15MP0004130_abnormal_muscle_cell2.70564546
16MP0005330_cardiomyopathy2.68364753
17MP0005551_abnormal_eye_electrophysiolog2.59152939
18MP0003724_increased_susceptibility_to2.47530080
19MP0001968_abnormal_touch/_nociception2.46515447
20MP0006138_congestive_heart_failure2.42626941
21MP0002102_abnormal_ear_morphology2.32881423
22MP0008775_abnormal_heart_ventricle2.30379326
23MP0001986_abnormal_taste_sensitivity2.25784086
24MP0002876_abnormal_thyroid_physiology2.21784090
25MP0008872_abnormal_physiological_respon2.21759614
26MP0006072_abnormal_retinal_apoptosis2.19716811
27MP0000749_muscle_degeneration2.18418011
28MP0005385_cardiovascular_system_phenoty2.16643513
29MP0001544_abnormal_cardiovascular_syste2.16643513
30MP0002972_abnormal_cardiac_muscle2.14711080
31MP0003787_abnormal_imprinting2.12835498
32MP0005646_abnormal_pituitary_gland2.06672758
33MP0001501_abnormal_sleep_pattern2.03130736
34MP0005360_urolithiasis2.01099583
35MP0005666_abnormal_adipose_tissue1.96247995
36MP0005645_abnormal_hypothalamus_physiol1.95818708
37MP0004087_abnormal_muscle_fiber1.93675604
38MP0000569_abnormal_digit_pigmentation1.93614129
39MP0004484_altered_response_of1.93509437
40MP0010630_abnormal_cardiac_muscle1.92877021
41MP0002638_abnormal_pupillary_reflex1.91937573
42MP0004885_abnormal_endolymph1.89801654
43MP0005620_abnormal_muscle_contractility1.89398583
44MP0009745_abnormal_behavioral_response1.85966503
45MP0000750_abnormal_muscle_regeneration1.85398697
46MP0004043_abnormal_pH_regulation1.84583653
47MP0002736_abnormal_nociception_after1.83649300
48MP0005085_abnormal_gallbladder_physiolo1.80461794
49MP0005253_abnormal_eye_physiology1.78637377
50MP0000372_irregular_coat_pigmentation1.74624022
51MP0000013_abnormal_adipose_tissue1.71236963
52MP0009046_muscle_twitch1.70099376
53MP0002139_abnormal_hepatobiliary_system1.70084936
54MP0005671_abnormal_response_to1.68524376
55MP0004085_abnormal_heartbeat1.61811518
56MP0003191_abnormal_cellular_cholesterol1.61053879
57MP0003011_delayed_dark_adaptation1.60594513
58MP0002332_abnormal_exercise_endurance1.60521047
59MP0002272_abnormal_nervous_system1.58832844
60MP0000343_altered_response_to1.58098323
61MP0005365_abnormal_bile_salt1.57594086
62MP0006276_abnormal_autonomic_nervous1.56436663
63MP0006292_abnormal_olfactory_placode1.55880485
64MP0003705_abnormal_hypodermis_morpholog1.55517242
65MP0002127_abnormal_cardiovascular_syste1.53367333
66MP0004147_increased_porphyrin_level1.50331364
67MP0003136_yellow_coat_color1.50275585
68MP0010329_abnormal_lipoprotein_level1.50104324
69MP0005165_increased_susceptibility_to1.49142511
70MP0003880_abnormal_central_pattern1.49043403
71MP0003279_aneurysm1.48215601
72MP0003950_abnormal_plasma_membrane1.48116611
73MP0004142_abnormal_muscle_tone1.47974084
74MP0003137_abnormal_impulse_conducting1.47556386
75MP0004133_heterotaxia1.44627511
76MP0005375_adipose_tissue_phenotype1.43033122
77MP0004185_abnormal_adipocyte_glucose1.42592017
78MP0000427_abnormal_hair_cycle1.41360011
79MP0002653_abnormal_ependyma_morphology1.40777137
80MP0006054_spinal_hemorrhage1.36573320
81MP0000767_abnormal_smooth_muscle1.36532152
82MP0002106_abnormal_muscle_physiology1.34162999
83MP0001485_abnormal_pinna_reflex1.33968851
84MP0001486_abnormal_startle_reflex1.33076074
85MP0000631_abnormal_neuroendocrine_gland1.32666196
86MP0002138_abnormal_hepatobiliary_system1.27135684
87MP0008438_abnormal_cutaneous_collagen1.25708186
88MP0005174_abnormal_tail_pigmentation1.22734284
89MP0001984_abnormal_olfaction1.22074550
90MP0002735_abnormal_chemical_nociception1.19496937
91MP0002572_abnormal_emotion/affect_behav1.18809278
92MP0001970_abnormal_pain_threshold1.18208365
93MP0002733_abnormal_thermal_nociception1.18175276
94MP0003283_abnormal_digestive_organ1.17061074
95MP0008875_abnormal_xenobiotic_pharmacok1.16901242
96MP0002269_muscular_atrophy1.15526998
97MP0002064_seizures1.14724155
98MP0000249_abnormal_blood_vessel1.13936826
99MP0002128_abnormal_blood_circulation1.13431324
100MP0005369_muscle_phenotype1.13034252
101MP0005595_abnormal_vascular_smooth1.12591893
102MP0003252_abnormal_bile_duct1.11581047
103MP0005386_behavior/neurological_phenoty1.10384655
104MP0004924_abnormal_behavior1.10384655
105MP0010386_abnormal_urinary_bladder1.09464163
106MP0003566_abnormal_cell_adhesion1.09115963
107MP0000759_abnormal_skeletal_muscle1.07638186
108MP0002938_white_spotting1.07174251
109MP0004742_abnormal_vestibular_system1.07031270
110MP0001905_abnormal_dopamine_level1.06978267
111MP0000230_abnormal_systemic_arterial1.06610331
112MP0005389_reproductive_system_phenotype1.06200711
113MP0002295_abnormal_pulmonary_circulatio1.05556187
114MP0002557_abnormal_social/conspecific_i1.04569559
115MP0000003_abnormal_adipose_tissue1.04451478
116MP0003221_abnormal_cardiomyocyte_apopto1.03898711
117MP0005377_hearing/vestibular/ear_phenot1.02984132
118MP0003878_abnormal_ear_physiology1.02984132
119MP0002118_abnormal_lipid_homeostasis1.02871274
120MP0005379_endocrine/exocrine_gland_phen1.01762771
121MP0005410_abnormal_fertilization1.01211463
122MP0006036_abnormal_mitochondrial_physio1.00976579
123MP0000266_abnormal_heart_morphology1.00375342
124MP0001919_abnormal_reproductive_system1.00352220
125MP0002971_abnormal_brown_adipose0.99057907
126MP0001502_abnormal_circadian_rhythm0.97617956
127MP0005195_abnormal_posterior_eye0.97163489
128MP0005075_abnormal_melanosome_morpholog0.97086695
129MP0002928_abnormal_bile_duct0.97016095
130MP0002067_abnormal_sensory_capabilities0.96982438
131MP0004145_abnormal_muscle_electrophysio0.96802253
132MP0000383_abnormal_hair_follicle0.95606211
133MP0005319_abnormal_enzyme/_coenzyme0.95045662
134MP0001529_abnormal_vocalization0.94637662
135MP0002693_abnormal_pancreas_physiology0.93402808
136MP0001958_emphysema0.91833332
137MP0002234_abnormal_pharynx_morphology0.91153513
138MP0004510_myositis0.90988603
139MP0003718_maternal_effect0.89966177
140MP0005332_abnormal_amino_acid0.89648172
141MP0000747_muscle_weakness0.87538085
142MP0002277_abnormal_respiratory_mucosa0.86649373
143MP0002095_abnormal_skin_pigmentation0.86399044
144MP0002163_abnormal_gland_morphology0.85610246
145MP0003635_abnormal_synaptic_transmissio0.84343310
146MP0008995_early_reproductive_senescence0.83598320
147MP0002063_abnormal_learning/memory/cond0.83532389
148MP0002925_abnormal_cardiovascular_devel0.83009867
149MP0005275_abnormal_skin_tensile0.82539694
150MP0000609_abnormal_liver_physiology0.81912888
151MP0009764_decreased_sensitivity_to0.81713196
152MP0001614_abnormal_blood_vessel0.81516485
153MP0002160_abnormal_reproductive_system0.81246925
154MP0001764_abnormal_homeostasis0.80785139
155MP0002909_abnormal_adrenal_gland0.77764903
156MP0008058_abnormal_DNA_repair0.77475714
157MP0009643_abnormal_urine_homeostasis0.77390586
158MP0005448_abnormal_energy_balance0.76824845
159MP0009278_abnormal_bone_marrow0.75610552
160MP0002108_abnormal_muscle_morphology0.75386113
161MP0005623_abnormal_meninges_morphology0.75189628
162MP0003567_abnormal_fetal_cardiomyocyte0.72957960
163MP0005083_abnormal_biliary_tract0.71839403
164MP0005164_abnormal_response_to0.71628110
165MP0003698_abnormal_male_reproductive0.71162112
166MP0002752_abnormal_somatic_nervous0.71124266
167MP0004883_abnormal_blood_vessel0.70927617
168MP0003806_abnormal_nucleotide_metabolis0.70872074
169MP0000026_abnormal_inner_ear0.70499880
170MP0009115_abnormal_fat_cell0.70094927
171MP0009697_abnormal_copulation0.69249680
172MP0003300_gastrointestinal_ulcer0.68426815
173MP0009840_abnormal_foam_cell0.66223405
174MP0008961_abnormal_basal_metabolism0.65480428
175MP0005334_abnormal_fat_pad0.63772619
176MP0005266_abnormal_metabolism0.58477849
177MP0001756_abnormal_urination0.58215931
178MP0008004_abnormal_stomach_pH0.58180322
179MP0005187_abnormal_penis_morphology0.57118869
180MP0005535_abnormal_body_temperature0.56569955
181MP0005084_abnormal_gallbladder_morpholo0.55710964
182MP0002078_abnormal_glucose_homeostasis0.52845726

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.88522189
2Ventricular tachycardia (HP:0004756)5.56424392
3Muscle fiber splitting (HP:0003555)5.08231673
4Atrial fibrillation (HP:0005110)4.62105790
5Pancreatic cysts (HP:0001737)4.53110596
6Polycythemia (HP:0001901)4.51751201
7Congenital stationary night blindness (HP:0007642)4.43243328
8Increased connective tissue (HP:0009025)4.28282471
9Primary atrial arrhythmia (HP:0001692)4.25449486
10Hyporeflexia of lower limbs (HP:0002600)4.25015301
11Right ventricular cardiomyopathy (HP:0011663)4.24652532
12Lipoatrophy (HP:0100578)4.17715212
13Supraventricular arrhythmia (HP:0005115)4.17035723
14Supraventricular tachycardia (HP:0004755)4.06957331
15Calf muscle hypertrophy (HP:0008981)4.04548989
16Pancreatic fibrosis (HP:0100732)4.00764775
17Exercise-induced muscle cramps (HP:0003710)4.00651535
18Myoglobinuria (HP:0002913)3.96779717
19Exercise-induced myalgia (HP:0003738)3.94545264
20Hypoglycemic coma (HP:0001325)3.82823975
21Abnormality of midbrain morphology (HP:0002418)3.82131534
22Molar tooth sign on MRI (HP:0002419)3.82131534
23True hermaphroditism (HP:0010459)3.79608569
24Muscle hypertrophy of the lower extremities (HP:0008968)3.68035195
25Difficulty running (HP:0009046)3.66124728
26Abnormality of the renal cortex (HP:0011035)3.49015033
27Nephronophthisis (HP:0000090)3.48608854
28Dilated cardiomyopathy (HP:0001644)3.45338039
29Syncope (HP:0001279)3.40254917
30Attenuation of retinal blood vessels (HP:0007843)3.33219691
31Abnormality of the calf musculature (HP:0001430)3.31505743
32Type II lissencephaly (HP:0007260)3.30558716
33Palpitations (HP:0001962)3.26784066
34Deep venous thrombosis (HP:0002625)3.24336888
35Ketoacidosis (HP:0001993)3.20851095
36Prolonged QT interval (HP:0001657)3.20589284
37Abnormality of the renal medulla (HP:0100957)3.14070437
38Rhabdomyolysis (HP:0003201)3.14024541
39Atrioventricular block (HP:0001678)3.13969664
40EMG: myopathic abnormalities (HP:0003458)3.13894731
41Esophageal varix (HP:0002040)3.12967666
42Abnormality of fatty-acid metabolism (HP:0004359)3.08266133
43Broad metatarsal (HP:0001783)3.06840741
44Spontaneous hematomas (HP:0007420)3.05496687
45Cerebral hemorrhage (HP:0001342)3.03254911
46Abolished electroretinogram (ERG) (HP:0000550)3.03245124
47Lymphangioma (HP:0100764)3.01252606
48Hyperventilation (HP:0002883)2.96284789
49Bundle branch block (HP:0011710)2.95266180
50Heart block (HP:0012722)2.94385512
51Hyperglycinuria (HP:0003108)2.92428430
52Myotonia (HP:0002486)2.91869860
53Asymmetric septal hypertrophy (HP:0001670)2.91430305
54Ketosis (HP:0001946)2.90368659
55Subaortic stenosis (HP:0001682)2.86869122
56Abnormality of the left ventricular outflow tract (HP:0011103)2.86869122
57Hematochezia (HP:0002573)2.84912494
58Abnormal atrioventricular conduction (HP:0005150)2.81708745
59Hypoalphalipoproteinemia (HP:0003233)2.80647920
60Medial flaring of the eyebrow (HP:0010747)2.79779119
61Pendular nystagmus (HP:0012043)2.77381214
62Abnormal drinking behavior (HP:0030082)2.76550854
63Polydipsia (HP:0001959)2.76550854
64Abnormal rod and cone electroretinograms (HP:0008323)2.74563734
65Tubular atrophy (HP:0000092)2.74187826
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.73600678
67Dicarboxylic aciduria (HP:0003215)2.73600678
68Cystic liver disease (HP:0006706)2.72253457
69Hyperammonemia (HP:0001987)2.68173508
70Decreased central vision (HP:0007663)2.65730587
71Renal cortical cysts (HP:0000803)2.65635193
72Ventricular arrhythmia (HP:0004308)2.65592163
73Increased variability in muscle fiber diameter (HP:0003557)2.64108437
74Chronic hepatic failure (HP:0100626)2.61328562
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60566903
76Abnormality of alanine metabolism (HP:0010916)2.60566903
77Hyperalaninemia (HP:0003348)2.60566903
78Difficulty climbing stairs (HP:0003551)2.60243249
79Nonimmune hydrops fetalis (HP:0001790)2.56741985
80Facial diplegia (HP:0001349)2.55957179
81Muscle stiffness (HP:0003552)2.54989778
82Stomach cancer (HP:0012126)2.52061387
83Absent rod-and cone-mediated responses on ERG (HP:0007688)2.48159080
84Large for gestational age (HP:0001520)2.46348188
85Congenital, generalized hypertrichosis (HP:0004540)2.44815006
86Abnormality of serine family amino acid metabolism (HP:0010894)2.44655957
87Abnormality of glycine metabolism (HP:0010895)2.44655957
88Abnormality of skeletal muscle fiber size (HP:0012084)2.43307937
89Inability to walk (HP:0002540)2.42658037
90Polyuria (HP:0000103)2.37615217
91Keratoconus (HP:0000563)2.36852496
92Increased corneal curvature (HP:0100692)2.36852496
93Visceral angiomatosis (HP:0100761)2.36643193
94Decreased electroretinogram (ERG) amplitude (HP:0000654)2.35993807
95Distal lower limb muscle weakness (HP:0009053)2.35711892
96Gaze-evoked nystagmus (HP:0000640)2.35403678
97Hyperinsulinemic hypoglycemia (HP:0000825)2.35225630
98Sclerocornea (HP:0000647)2.34116945
99Methylmalonic aciduria (HP:0012120)2.33568105
100Cavernous hemangioma (HP:0001048)2.32476000
101Bile duct proliferation (HP:0001408)2.32347528
102Abnormal biliary tract physiology (HP:0012439)2.32347528
103Methylmalonic acidemia (HP:0002912)2.32310079
104Mesangial abnormality (HP:0001966)2.30394126
105Xanthomatosis (HP:0000991)2.30196321
106Ventricular fibrillation (HP:0001663)2.29465556
107Mitochondrial inheritance (HP:0001427)2.29278890
108Hyperlipoproteinemia (HP:0010980)2.29164755
109Decreased circulating renin level (HP:0003351)2.27352098
110Cerebellar dysplasia (HP:0007033)2.27337898
111Acute necrotizing encephalopathy (HP:0006965)2.25672912
112Lissencephaly (HP:0001339)2.24306052
113Hemangiomatosis (HP:0007461)2.21846789
114Abnormality of the nasal mucosa (HP:0000433)2.20161371
115Cerebral aneurysm (HP:0004944)2.20127507
116Broad-based gait (HP:0002136)2.19859119
117Testicular atrophy (HP:0000029)2.19322135
118Increased CSF lactate (HP:0002490)2.17988484
119Acanthosis nigricans (HP:0000956)2.17526230
120Congenital hepatic fibrosis (HP:0002612)2.17208272
1213-Methylglutaconic aciduria (HP:0003535)2.16973770
122Progressive inability to walk (HP:0002505)2.16753914
123Thyroiditis (HP:0100646)2.14744166
124Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.13933393
125Furrowed tongue (HP:0000221)2.13731942
126Hemorrhage of the eye (HP:0011885)2.12912090
127Spinal rigidity (HP:0003306)2.12008261
128Gait imbalance (HP:0002141)2.09295555
129Hypoproteinemia (HP:0003075)2.08628108
130Optic disc pallor (HP:0000543)2.07999660
131Abnormal EKG (HP:0003115)2.07924657
132Aplasia/Hypoplasia of the tibia (HP:0005772)2.07279655
133Abnormality of the pons (HP:0007361)2.06261327
134Aplasia/Hypoplasia of the spleen (HP:0010451)2.04551636
135Anencephaly (HP:0002323)2.04274350
136Hepatic necrosis (HP:0002605)2.03654230
137Hypothermia (HP:0002045)2.03085609
138IgG deficiency (HP:0004315)2.02645769
139Intrahepatic cholestasis (HP:0001406)2.02502055
140Congenital primary aphakia (HP:0007707)2.01281101
141Progressive macrocephaly (HP:0004481)2.01171601
142Hypoplasia of the pons (HP:0012110)2.00404100
143Pulmonary artery stenosis (HP:0004415)1.99598782
144Clumsiness (HP:0002312)1.99155148
145Stomatitis (HP:0010280)1.98993957
146Type 1 muscle fiber predominance (HP:0003803)1.98914294
147Complement deficiency (HP:0004431)1.98260650
148Aneurysm (HP:0002617)1.98023457
149Hypoplastic ischia (HP:0003175)1.97763898
150Areflexia of lower limbs (HP:0002522)1.97201512
151Increased muscle lipid content (HP:0009058)1.96776004
152Acute encephalopathy (HP:0006846)1.96369839
153Aplasia/Hypoplasia of the tongue (HP:0010295)1.95996541
154Neonatal death (HP:0003811)1.94717291
155Optic nerve hypoplasia (HP:0000609)1.92668645
156Progressive cerebellar ataxia (HP:0002073)1.92410735
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91898179
158Abnormal urine output (HP:0012590)1.90881552
159Generalized aminoaciduria (HP:0002909)1.90764476
160Bony spicule pigmentary retinopathy (HP:0007737)1.90453728
161Cerebral edema (HP:0002181)1.90263704
162Pachygyria (HP:0001302)1.90146810
163Protruding tongue (HP:0010808)1.89935515
164Abnormal mitochondria in muscle tissue (HP:0008316)1.89469664
165Dynein arm defect of respiratory motile cilia (HP:0012255)1.89097153
166Absent/shortened dynein arms (HP:0200106)1.89097153
167Severe muscular hypotonia (HP:0006829)1.89047000
168Male pseudohermaphroditism (HP:0000037)1.87738242
169Pancreatic islet-cell hyperplasia (HP:0004510)1.87720953
170Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.87425071
171Asplenia (HP:0001746)1.87307311
172Abnormality of the ischium (HP:0003174)1.86864207
173Lipid accumulation in hepatocytes (HP:0006561)1.86862875
174Joint hemorrhage (HP:0005261)1.86183048
175Generalized muscle weakness (HP:0003324)1.86107742
176Nephrogenic diabetes insipidus (HP:0009806)1.86091805
177Congestive heart failure (HP:0001635)1.85769023
178Conjunctival telangiectasia (HP:0000524)1.85591142
179Hypolipoproteinemia (HP:0010981)1.85424559
180Hyperglycemia (HP:0003074)1.85230319
181Hypertriglyceridemia (HP:0002155)1.82608524
182Hepatocellular necrosis (HP:0001404)1.82599880
183Postaxial foot polydactyly (HP:0001830)1.81250556
184Palmoplantar keratoderma (HP:0000982)1.81222057
185Abnormality of the intrinsic pathway (HP:0010989)1.80872472
186Nausea (HP:0002018)1.80447491
187Hemiparesis (HP:0001269)1.80137519
188Severe combined immunodeficiency (HP:0004430)1.79620934
189Genetic anticipation (HP:0003743)1.79159668
190Febrile seizures (HP:0002373)1.74286335
191Chorioretinal atrophy (HP:0000533)1.73808819
192Colon cancer (HP:0003003)1.71558946
193Fair hair (HP:0002286)1.69899065
194Patellar aplasia (HP:0006443)1.69486636
195Absent speech (HP:0001344)1.69353308
196Abnormality of B cell number (HP:0010975)1.68772025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE18.94568917
2KDR5.92058252
3FRK5.24836687
4ADRBK23.47859164
5ZAK3.18741262
6TGFBR23.17063620
7TTN3.16383566
8BMPR1B2.92674606
9MYLK2.74964350
10TAOK32.65650696
11MAP4K22.51428761
12TXK2.47775778
13TLK12.41684180
14BCKDK2.39938109
15NUAK12.38815539
16WNK32.28736608
17TRIB32.23369804
18PDK22.12964203
19RIPK12.07734054
20ACVR1B2.01368467
21OBSCN1.89780678
22PHKG11.88199406
23PHKG21.88199406
24LMTK21.87958730
25MAPK131.77939990
26PDK41.76519683
27PDK31.76519683
28TGFBR11.70564539
29PKN21.68587574
30EPHB21.62110673
31DMPK1.61723206
32ERN11.59874521
33PTK2B1.55924851
34INSRR1.54703831
35GRK11.50067889
36DAPK21.49293701
37OXSR11.46923198
38SIK11.30298433
39ADRBK11.27846346
40MAP3K41.25207967
41MAPK121.22486448
42FGFR41.22231966
43MAP2K31.22191326
44PTK61.14905289
45PRKD11.14089119
46EPHB11.13711136
47CASK1.10519326
48FER1.10106324
49PIK3CA1.07314483
50CAMKK21.05891392
51PRKAA21.03761032
52MAP3K31.03559108
53WNK41.00961593
54VRK11.00928487
55TEC0.97153481
56DYRK20.97124754
57CAMK1D0.96402421
58VRK20.96242296
59PINK10.95417547
60ITK0.94395531
61MARK10.93739359
62PDGFRA0.92298046
63MKNK20.89158719
64PRKG20.86806041
65TNIK0.84994124
66PRKCQ0.82447704
67PRKCG0.82343205
68TRIM280.82255182
69KIT0.80573290
70MAP3K70.75480601
71CSNK1G10.74972610
72CSNK1G20.74938151
73CAMK1G0.72344341
74CSNK1G30.70164469
75TNK20.70071590
76BRSK20.68608362
77MAP2K60.68489635
78IKBKB0.67962457
79PLK20.64311257
80PRKAA10.63107029
81CAMK40.62197351
82RPS6KA50.61526612
83PAK30.59159388
84ERBB30.58848229
85JAK10.58619194
86MAPKAPK50.57968634
87NTRK30.57620279
88ILK0.57261653
89FES0.55877861
90SYK0.55492385
91PRKCH0.54353067
92GRK70.53987869
93MAPKAPK30.53643623
94CAMK2A0.53330466
95CSNK1A1L0.53189871
96MST40.52811007
97GRK50.52799371
98MAPK70.52727325
99ROCK10.52716761
100MAP2K70.51889589
101PDPK10.51070496
102CSK0.49821055
103AKT30.49786587
104MAP4K10.49685538
105PRKACA0.48699300
106MAPK150.48202413
107NME10.48010069
108NEK90.47626057
109PAK40.46241296
110CHUK0.46066356
111FGFR30.45576978
112STK240.45501771
113PNCK0.44498087
114NLK0.44186254
115MUSK0.44066765
116PRKD30.42742626
117GSK3A0.42412279
118JAK20.42348807
119EPHA40.41878128
120STK390.41873661
121TAF10.41608690
122PLK30.40754671
123PRKCA0.39823598
124EPHA30.39666932
125PRKCI0.39535196
126STK110.38135024
127NEK10.37843946
128CSNK1A10.37699454
129LCK0.37626684
130FGFR20.36725447
131PKN10.35778348
132PTK20.35659786
133TBK10.35650384
134FLT30.35273603
135TRPM70.35269349
136LRRK20.34572454
137IKBKE0.34302755
138PASK0.34177222
139TESK20.33961016
140DAPK30.33953632
141MET0.32875584
142LATS10.32637177
143IGF1R0.32589630
144NTRK20.32561794
145CSNK1D0.32384988
146PRKACG0.32339271
147MAP2K10.32262742
148RET0.31679820
149NEK20.31568020
150PRKCE0.31506845
151PIK3CG0.31011192
152PRKG10.30559770
153LYN0.30264538
154CAMK2D0.30069247
155PRKACB0.28026942
156CAMK10.26753906
157PRKD20.26456304
158CDC42BPA0.24686834
159MAPK40.24314816
160MTOR0.24308855
161STK38L0.23928987
162MAP3K10.23691156
163AKT20.23523454
164MARK30.23405379
165PDK10.23090425
166TYK20.22594838
167MAP2K20.22119064
168MARK20.21459950
169MAPK110.21356899
170PDGFRB0.20911010
171SRC0.20805907
172PAK20.19706588

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.84004869
2Propanoate metabolism_Homo sapiens_hsa006403.42243155
3Fatty acid degradation_Homo sapiens_hsa000713.40993464
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.31285772
5Phototransduction_Homo sapiens_hsa047442.99621777
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.95896521
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.87977594
8Linoleic acid metabolism_Homo sapiens_hsa005912.68906870
9PPAR signaling pathway_Homo sapiens_hsa033202.64055665
10Fatty acid metabolism_Homo sapiens_hsa012122.63322143
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.62148998
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29872500
13Arginine biosynthesis_Homo sapiens_hsa002202.29090231
14Dilated cardiomyopathy_Homo sapiens_hsa054142.20397406
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.11745793
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.03482267
17Tryptophan metabolism_Homo sapiens_hsa003802.02881318
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.02458257
19Primary immunodeficiency_Homo sapiens_hsa053401.96124291
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.95855500
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.93912216
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90900781
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.86652473
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.81165812
25Nicotine addiction_Homo sapiens_hsa050331.80467929
26Carbon metabolism_Homo sapiens_hsa012001.77768337
27Cardiac muscle contraction_Homo sapiens_hsa042601.77609429
28Butanoate metabolism_Homo sapiens_hsa006501.75005478
29Pyruvate metabolism_Homo sapiens_hsa006201.73499385
30Ether lipid metabolism_Homo sapiens_hsa005651.70474968
31Complement and coagulation cascades_Homo sapiens_hsa046101.69833007
32RNA polymerase_Homo sapiens_hsa030201.64819663
33Nitrogen metabolism_Homo sapiens_hsa009101.63901134
34Homologous recombination_Homo sapiens_hsa034401.61061560
35Protein export_Homo sapiens_hsa030601.60937929
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53413584
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.53411926
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44187475
39beta-Alanine metabolism_Homo sapiens_hsa004101.42715962
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41188773
41Fatty acid elongation_Homo sapiens_hsa000621.39395410
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38985385
43Bile secretion_Homo sapiens_hsa049761.38096265
44Taste transduction_Homo sapiens_hsa047421.38079090
45Peroxisome_Homo sapiens_hsa041461.37287024
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.34088344
47Basal transcription factors_Homo sapiens_hsa030221.33596449
48Fanconi anemia pathway_Homo sapiens_hsa034601.33048851
49Caffeine metabolism_Homo sapiens_hsa002321.32221818
50Olfactory transduction_Homo sapiens_hsa047401.26793193
51Adipocytokine signaling pathway_Homo sapiens_hsa049201.24176732
52Morphine addiction_Homo sapiens_hsa050321.23639684
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22455871
54Fatty acid biosynthesis_Homo sapiens_hsa000611.22089050
55Insulin resistance_Homo sapiens_hsa049311.19417659
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16280887
57ECM-receptor interaction_Homo sapiens_hsa045121.15805840
58Fat digestion and absorption_Homo sapiens_hsa049751.12328027
59Asthma_Homo sapiens_hsa053101.10941353
60Regulation of autophagy_Homo sapiens_hsa041401.09280566
61Focal adhesion_Homo sapiens_hsa045101.07609736
62Starch and sucrose metabolism_Homo sapiens_hsa005001.07010496
63Arachidonic acid metabolism_Homo sapiens_hsa005901.06855359
64RNA degradation_Homo sapiens_hsa030181.04355263
65One carbon pool by folate_Homo sapiens_hsa006701.01109528
66Phenylalanine metabolism_Homo sapiens_hsa003601.00983479
67Type I diabetes mellitus_Homo sapiens_hsa049401.00826221
68Parkinsons disease_Homo sapiens_hsa050121.00622294
69Graft-versus-host disease_Homo sapiens_hsa053320.99746422
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99602050
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98864804
72Proteasome_Homo sapiens_hsa030500.98350543
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96475246
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95514454
75Lysine degradation_Homo sapiens_hsa003100.92865698
76Insulin secretion_Homo sapiens_hsa049110.88744287
77ABC transporters_Homo sapiens_hsa020100.88565387
78Autoimmune thyroid disease_Homo sapiens_hsa053200.88122702
79Oxidative phosphorylation_Homo sapiens_hsa001900.87251866
80Arginine and proline metabolism_Homo sapiens_hsa003300.86576660
81Serotonergic synapse_Homo sapiens_hsa047260.85302619
82Allograft rejection_Homo sapiens_hsa053300.85194855
83Staphylococcus aureus infection_Homo sapiens_hsa051500.84500883
84Viral myocarditis_Homo sapiens_hsa054160.84392259
85Glycerolipid metabolism_Homo sapiens_hsa005610.83543608
86GABAergic synapse_Homo sapiens_hsa047270.82771240
87Circadian entrainment_Homo sapiens_hsa047130.82316381
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79704968
89Adherens junction_Homo sapiens_hsa045200.78444476
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76338353
91AMPK signaling pathway_Homo sapiens_hsa041520.76101538
92Biosynthesis of amino acids_Homo sapiens_hsa012300.76040974
93Glutamatergic synapse_Homo sapiens_hsa047240.75563017
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.74021282
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73382029
96Alzheimers disease_Homo sapiens_hsa050100.72586845
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72545160
98Tyrosine metabolism_Homo sapiens_hsa003500.72359726
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71028149
100Glucagon signaling pathway_Homo sapiens_hsa049220.69569500
101Purine metabolism_Homo sapiens_hsa002300.67975045
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67802476
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65305855
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64466513
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.64151372
106Salivary secretion_Homo sapiens_hsa049700.64020395
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63486471
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62195576
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62018161
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60366606
111Chemical carcinogenesis_Homo sapiens_hsa052040.60357318
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59967439
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57419548
114Rheumatoid arthritis_Homo sapiens_hsa053230.56565988
115Collecting duct acid secretion_Homo sapiens_hsa049660.56506753
116Metabolic pathways_Homo sapiens_hsa011000.56434794
117HIF-1 signaling pathway_Homo sapiens_hsa040660.55502432
118Renin secretion_Homo sapiens_hsa049240.55425664
119Tight junction_Homo sapiens_hsa045300.53820547
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53233129
121Insulin signaling pathway_Homo sapiens_hsa049100.52968489
122Ovarian steroidogenesis_Homo sapiens_hsa049130.52842282
123Hematopoietic cell lineage_Homo sapiens_hsa046400.52430476
124Amoebiasis_Homo sapiens_hsa051460.52283740
125Vitamin digestion and absorption_Homo sapiens_hsa049770.52057851
126Antigen processing and presentation_Homo sapiens_hsa046120.51357390
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51177053
128Histidine metabolism_Homo sapiens_hsa003400.50996456
129Dorso-ventral axis formation_Homo sapiens_hsa043200.47916962
130Notch signaling pathway_Homo sapiens_hsa043300.45517859
131Mineral absorption_Homo sapiens_hsa049780.45384828
132Protein digestion and absorption_Homo sapiens_hsa049740.44582628
133Retinol metabolism_Homo sapiens_hsa008300.44553944
134Rap1 signaling pathway_Homo sapiens_hsa040150.44104585
135Pyrimidine metabolism_Homo sapiens_hsa002400.43469744
136Huntingtons disease_Homo sapiens_hsa050160.43143721
137Circadian rhythm_Homo sapiens_hsa047100.42844721
138Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41847536
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41048306
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40927311
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40740575
142Malaria_Homo sapiens_hsa051440.39774874
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36180742
144Platelet activation_Homo sapiens_hsa046110.33946310
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.33544659
146Amphetamine addiction_Homo sapiens_hsa050310.31797086
147Small cell lung cancer_Homo sapiens_hsa052220.31606136
148Dopaminergic synapse_Homo sapiens_hsa047280.31040252
149Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30635733
150Proteoglycans in cancer_Homo sapiens_hsa052050.30482805
151Steroid hormone biosynthesis_Homo sapiens_hsa001400.29094407
152Sulfur metabolism_Homo sapiens_hsa009200.28520974
153cAMP signaling pathway_Homo sapiens_hsa040240.27495018
154Galactose metabolism_Homo sapiens_hsa000520.26860980
155Selenocompound metabolism_Homo sapiens_hsa004500.24165345
156VEGF signaling pathway_Homo sapiens_hsa043700.21175691
157Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20182363
158Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20111099
159Calcium signaling pathway_Homo sapiens_hsa040200.19667934

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