USMG5P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.95021012
2lens fiber cell development (GO:0070307)7.21611898
3kidney morphogenesis (GO:0060993)6.81793649
4respiratory tube development (GO:0030323)6.59670147
5pyrimidine nucleobase catabolic process (GO:0006208)6.57158525
6behavioral response to nicotine (GO:0035095)6.44017699
7metanephric tubule development (GO:0072170)6.13027764
8metanephric nephron tubule development (GO:0072234)6.13027764
9lung epithelium development (GO:0060428)5.93218700
10dendritic spine morphogenesis (GO:0060997)5.74055830
11positive regulation of growth hormone secretion (GO:0060124)5.53671445
12metanephric nephron epithelium development (GO:0072243)5.40966409
13nucleobase catabolic process (GO:0046113)5.40872997
14collecting duct development (GO:0072044)5.30777131
15lung morphogenesis (GO:0060425)5.19592016
16ncRNA 3-end processing (GO:0043628)5.12990656
17metanephric epithelium development (GO:0072207)4.96605346
18regulation of growth hormone secretion (GO:0060123)4.78105749
19central nervous system myelination (GO:0022010)4.77891002
20axon ensheathment in central nervous system (GO:0032291)4.77891002
21lung-associated mesenchyme development (GO:0060484)4.64265579
22termination of RNA polymerase III transcription (GO:0006386)4.53595347
23transcription elongation from RNA polymerase III promoter (GO:0006385)4.53595347
24establishment of mitochondrion localization (GO:0051654)4.49580214
25axonal fasciculation (GO:0007413)4.46361758
26regulation of protein glycosylation (GO:0060049)4.44804666
27cartilage morphogenesis (GO:0060536)4.43389474
28substrate-independent telencephalic tangential migration (GO:0021826)4.36425410
29substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.36425410
30retinal ganglion cell axon guidance (GO:0031290)4.36252552
31establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.32761902
32mitochondrion transport along microtubule (GO:0047497)4.32761902
33base-excision repair, AP site formation (GO:0006285)3.94108435
34anatomical structure regression (GO:0060033)3.79425592
35cell migration in hindbrain (GO:0021535)3.71348752
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.71149353
37nephron tubule development (GO:0072080)3.62597528
38purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.55630090
39cell proliferation in forebrain (GO:0021846)3.50838613
40myoblast migration (GO:0051451)3.48733491
41neuron recognition (GO:0008038)3.47636902
42pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.45396406
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.44874330
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.44874330
45NADH dehydrogenase complex assembly (GO:0010257)3.44874330
46arginine catabolic process (GO:0006527)3.33608524
47adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.33038358
48cerebellar Purkinje cell differentiation (GO:0021702)3.25732373
49dendritic spine organization (GO:0097061)3.25720770
50pyrimidine nucleotide catabolic process (GO:0006244)3.24304101
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.23405797
52ATP synthesis coupled proton transport (GO:0015986)3.22035649
53energy coupled proton transport, down electrochemical gradient (GO:0015985)3.22035649
54viral transcription (GO:0019083)3.19143072
55positive regulation of CREB transcription factor activity (GO:0032793)3.16929955
56regulation of synapse structural plasticity (GO:0051823)3.14650621
57cAMP biosynthetic process (GO:0006171)3.14333948
58negative regulation of oligodendrocyte differentiation (GO:0048715)3.11364338
59negative regulation of multicellular organism growth (GO:0040015)3.11321738
60protein polyglutamylation (GO:0018095)3.09334827
61renal tubule development (GO:0061326)3.07303922
62N-acetylglucosamine metabolic process (GO:0006044)3.04751648
63regulation of glycogen (starch) synthase activity (GO:2000465)3.04703042
64phosphorelay signal transduction system (GO:0000160)3.00914248
65translational termination (GO:0006415)3.00481392
66positive regulation of dendritic spine morphogenesis (GO:0061003)2.96824257
67cardiovascular system development (GO:0072358)2.95814073
68regulation of chromatin binding (GO:0035561)2.93287111
69ribosomal small subunit biogenesis (GO:0042274)2.88036659
70epithelial cilium movement (GO:0003351)2.87787559
71glycosphingolipid biosynthetic process (GO:0006688)2.87260597
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.87050546
73positive regulation of mitochondrial fission (GO:0090141)2.86243190
74axon extension (GO:0048675)2.85474995
75positive regulation of cAMP-mediated signaling (GO:0043950)2.85451082
76behavioral response to ethanol (GO:0048149)2.83824727
77neuronal ion channel clustering (GO:0045161)2.77507017
78nephron epithelium development (GO:0072009)2.74346332
79negative regulation of macroautophagy (GO:0016242)2.73162029
80negative regulation of glycoprotein biosynthetic process (GO:0010561)2.72534393
81apoptotic process involved in development (GO:1902742)2.70767965
82viral protein processing (GO:0019082)2.70403907
83L-fucose catabolic process (GO:0042355)2.69642041
84fucose catabolic process (GO:0019317)2.69642041
85L-fucose metabolic process (GO:0042354)2.69642041
86synaptic transmission, cholinergic (GO:0007271)2.66322110
87regulation of feeding behavior (GO:0060259)2.66111086
88autophagic vacuole fusion (GO:0000046)2.65703009
89negative regulation of smoothened signaling pathway (GO:0045879)2.65447599
90startle response (GO:0001964)2.62876907
91nonmotile primary cilium assembly (GO:0035058)2.62225734
92body morphogenesis (GO:0010171)2.62138910
93negative regulation of glial cell differentiation (GO:0045686)2.60165247
94N-glycan processing (GO:0006491)2.57444959
95layer formation in cerebral cortex (GO:0021819)2.56405368
96glycoprotein catabolic process (GO:0006516)2.55879838
97neuron projection extension involved in neuron projection guidance (GO:1902284)2.52938066
98axon extension involved in axon guidance (GO:0048846)2.52938066
99transmission of nerve impulse (GO:0019226)2.52241649
100head development (GO:0060322)2.51557574

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.60922915
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.28582731
3VDR_22108803_ChIP-Seq_LS180_Human4.15122387
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.95792529
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.25800972
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.81637710
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.80428357
8ZNF274_21170338_ChIP-Seq_K562_Hela2.79907041
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.74311290
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.62890719
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.59892291
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50654580
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.40658175
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.24959217
15DROSHA_22980978_ChIP-Seq_HELA_Human2.16249490
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07583569
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07116294
18REST_21632747_ChIP-Seq_MESCs_Mouse2.04132404
19RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.00876747
20TAF15_26573619_Chip-Seq_HEK293_Human2.00796794
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.98290431
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91001515
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86943416
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82030248
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.81428119
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.81428119
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.80602234
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77259341
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.76137285
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.74198088
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70432069
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66359865
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65466920
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.63389157
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59907164
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57307363
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56912918
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54086886
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.42515646
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41723628
41AR_21572438_ChIP-Seq_LNCaP_Human1.40593002
42TP53_20018659_ChIP-ChIP_R1E_Mouse1.39664918
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38624143
44RNF2_27304074_Chip-Seq_NSC_Mouse1.37929225
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33905988
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28291051
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26363792
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23634094
49FUS_26573619_Chip-Seq_HEK293_Human1.22657495
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21796082
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19516814
52GBX2_23144817_ChIP-Seq_PC3_Human1.19282792
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17290526
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17250614
55IRF1_19129219_ChIP-ChIP_H3396_Human1.16512878
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13723460
57OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10894777
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07557529
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07543088
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07093647
61SMAD3_21741376_ChIP-Seq_ESCs_Human1.06744581
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05889287
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05356115
64CTCF_27219007_Chip-Seq_Bcells_Human1.04814702
65SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02991490
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01303955
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00016669
68E2F1_17053090_ChIP-ChIP_MCF-7_Human0.99008622
69GATA3_21878914_ChIP-Seq_MCF-7_Human0.95815396
70IGF1R_20145208_ChIP-Seq_DFB_Human0.94275804
71EWS_26573619_Chip-Seq_HEK293_Human0.93686000
72P300_19829295_ChIP-Seq_ESCs_Human0.92876257
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92124200
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91371226
75TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91123686
76GABP_17652178_ChIP-ChIP_JURKAT_Human0.89357464
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89064877
78STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88798001
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88682953
80SMAD4_21799915_ChIP-Seq_A2780_Human0.88650481
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86954890
82MYC_19829295_ChIP-Seq_ESCs_Human0.83883410
83ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83803059
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83371367
85SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82579439
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.81773032
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81365957
88SOX2_16153702_ChIP-ChIP_HESCs_Human0.80346997
89ER_23166858_ChIP-Seq_MCF-7_Human0.78973473
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78058546
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76838396
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.76784299
93AR_25329375_ChIP-Seq_VCAP_Human0.75932699
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.75540040
95KDM2B_26808549_Chip-Seq_K562_Human0.75260849
96TAF2_19829295_ChIP-Seq_ESCs_Human0.74335362
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.73806857
98MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.72925706
99MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.72156030
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.72041539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.04344174
2MP0010030_abnormal_orbit_morphology3.64837191
3MP0005083_abnormal_biliary_tract3.60167301
4MP0005646_abnormal_pituitary_gland3.00676859
5MP0004859_abnormal_synaptic_plasticity2.91229196
6MP0004742_abnormal_vestibular_system2.75007356
7MP0004142_abnormal_muscle_tone2.71767386
8MP0001529_abnormal_vocalization2.67575641
9MP0002653_abnormal_ependyma_morphology2.59472010
10MP0003123_paternal_imprinting2.55658517
11MP0005248_abnormal_Harderian_gland2.52368398
12MP0003787_abnormal_imprinting2.45208109
13MP0000778_abnormal_nervous_system2.42025911
14MP0001346_abnormal_lacrimal_gland2.40306693
15MP0008789_abnormal_olfactory_epithelium2.38924944
16MP0000015_abnormal_ear_pigmentation2.38623754
17MP0003122_maternal_imprinting2.28382573
18MP0006292_abnormal_olfactory_placode2.18218566
19MP0005423_abnormal_somatic_nervous2.14002688
20MP0002102_abnormal_ear_morphology2.05995466
21MP0005394_taste/olfaction_phenotype2.01815357
22MP0005499_abnormal_olfactory_system2.01815357
23MP0008877_abnormal_DNA_methylation2.01384260
24MP0005084_abnormal_gallbladder_morpholo1.86780224
25MP0005645_abnormal_hypothalamus_physiol1.82568664
26MP0003646_muscle_fatigue1.80870755
27MP0002095_abnormal_skin_pigmentation1.80122197
28MP0003880_abnormal_central_pattern1.65236970
29MP0006276_abnormal_autonomic_nervous1.65193135
30MP0002089_abnormal_postnatal_growth/wei1.64584720
31MP0002184_abnormal_innervation1.64578307
32MP0002063_abnormal_learning/memory/cond1.62736427
33MP0003121_genomic_imprinting1.60064036
34MP0003635_abnormal_synaptic_transmissio1.56906020
35MP0001486_abnormal_startle_reflex1.51363020
36MP0003011_delayed_dark_adaptation1.50723752
37MP0001663_abnormal_digestive_system1.48687168
38MP0002734_abnormal_mechanical_nocicepti1.48324989
39MP0004885_abnormal_endolymph1.48079339
40MP0001970_abnormal_pain_threshold1.43728788
41MP0009745_abnormal_behavioral_response1.42987988
42MP0003718_maternal_effect1.42236021
43MP0002735_abnormal_chemical_nociception1.39695292
44MP0002837_dystrophic_cardiac_calcinosis1.38585545
45MP0001440_abnormal_grooming_behavior1.33374152
46MP0002736_abnormal_nociception_after1.31999321
47MP0008872_abnormal_physiological_respon1.29185518
48MP0002733_abnormal_thermal_nociception1.27208722
49MP0000955_abnormal_spinal_cord1.27068065
50MP0002064_seizures1.26270374
51MP0000049_abnormal_middle_ear1.25246737
52MP0002272_abnormal_nervous_system1.24854145
53MP0002557_abnormal_social/conspecific_i1.24501469
54MP0005551_abnormal_eye_electrophysiolog1.17542818
55MP0003315_abnormal_perineum_morphology1.16192618
56MP0002572_abnormal_emotion/affect_behav1.15299106
57MP0002638_abnormal_pupillary_reflex1.11341254
58MP0001968_abnormal_touch/_nociception1.11120860
59MP0002163_abnormal_gland_morphology1.10660035
60MP0001919_abnormal_reproductive_system1.10293707
61MP0003283_abnormal_digestive_organ1.09655221
62MP0002233_abnormal_nose_morphology1.07845642
63MP0004145_abnormal_muscle_electrophysio1.05909925
64MP0002067_abnormal_sensory_capabilities1.02632903
65MP0003186_abnormal_redox_activity1.02240355
66MP0005195_abnormal_posterior_eye1.01898686
67MP0002752_abnormal_somatic_nervous1.00656521
68MP0009278_abnormal_bone_marrow0.97984643
69MP0002882_abnormal_neuron_morphology0.97814117
70MP0002938_white_spotting0.96897747
71MP0000026_abnormal_inner_ear0.95920402
72MP0002822_catalepsy0.95411550
73MP0005381_digestive/alimentary_phenotyp0.93868078
74MP0003959_abnormal_lean_body0.92252710
75MP0005389_reproductive_system_phenotype0.89649050
76MP0000750_abnormal_muscle_regeneration0.88623503
77MP0002928_abnormal_bile_duct0.88226404
78MP0004811_abnormal_neuron_physiology0.87459946
79MP0001542_abnormal_bone_strength0.85125284
80MP0002152_abnormal_brain_morphology0.84793781
81MP0010386_abnormal_urinary_bladder0.83914305
82MP0009046_muscle_twitch0.83598936
83MP0002210_abnormal_sex_determination0.82598972
84MP0005377_hearing/vestibular/ear_phenot0.80879175
85MP0003878_abnormal_ear_physiology0.80879175
86MP0000631_abnormal_neuroendocrine_gland0.79885438
87MP0008770_decreased_survivor_rate0.79043408
88MP0002160_abnormal_reproductive_system0.78444322
89MP0004133_heterotaxia0.77025360
90MP0001986_abnormal_taste_sensitivity0.75326249
91MP0002132_abnormal_respiratory_system0.74345562
92MP0008057_abnormal_DNA_replication0.73608302
93MP0003937_abnormal_limbs/digits/tail_de0.73423926
94MP0001188_hyperpigmentation0.71815359
95MP0002066_abnormal_motor_capabilities/c0.71201171
96MP0006036_abnormal_mitochondrial_physio0.70357570
97MP0001905_abnormal_dopamine_level0.69520598
98MP0005257_abnormal_intraocular_pressure0.68990804
99MP0002229_neurodegeneration0.68777988
100MP0002116_abnormal_craniofacial_bone0.68008097

Predicted human phenotypes

RankGene SetZ-score
1Long foot (HP:0001833)5.55774940
2Macroorchidism (HP:0000053)4.61691175
3Multiple enchondromatosis (HP:0005701)4.36154350
4Absent rod-and cone-mediated responses on ERG (HP:0007688)4.05915897
5Myokymia (HP:0002411)3.90054121
6Pancreatic fibrosis (HP:0100732)3.72939666
7Abnormality of midbrain morphology (HP:0002418)3.52838702
8Molar tooth sign on MRI (HP:0002419)3.52838702
9Chronic hepatic failure (HP:0100626)3.25028442
10True hermaphroditism (HP:0010459)3.17166573
11Acute necrotizing encephalopathy (HP:0006965)3.11189865
12Amblyopia (HP:0000646)3.09798776
13Abnormal hemoglobin (HP:0011902)3.07328269
14Agitation (HP:0000713)3.01413897
15Pendular nystagmus (HP:0012043)2.94779269
16Pachygyria (HP:0001302)2.91964101
17Abolished electroretinogram (ERG) (HP:0000550)2.91285789
18Dyschromatopsia (HP:0007641)2.86697964
19Type II lissencephaly (HP:0007260)2.85228167
20Decreased central vision (HP:0007663)2.84339696
21Facial cleft (HP:0002006)2.82397831
22Pancreatic cysts (HP:0001737)2.81873311
23Hyperthyroidism (HP:0000836)2.78204915
24Abnormality of alanine metabolism (HP:0010916)2.77043596
25Hyperalaninemia (HP:0003348)2.77043596
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.77043596
27Abnormal rod and cone electroretinograms (HP:0008323)2.72333243
28Abnormality of the heme biosynthetic pathway (HP:0010472)2.67671794
29Hepatocellular necrosis (HP:0001404)2.66341195
30Abnormality of cells of the erythroid lineage (HP:0012130)2.66294322
31Lissencephaly (HP:0001339)2.65658505
32Abnormality of the renal medulla (HP:0100957)2.65165042
33Nephronophthisis (HP:0000090)2.60376357
34Abnormal mitochondria in muscle tissue (HP:0008316)2.55398022
35Hypoplasia of the brainstem (HP:0002365)2.54771965
36Aplasia/Hypoplasia of the brainstem (HP:0007362)2.54771965
37Palpebral edema (HP:0100540)2.53939593
38Cystic liver disease (HP:0006706)2.53622070
39Enlarged kidneys (HP:0000105)2.52919901
40Anophthalmia (HP:0000528)2.50874063
41Hepatic necrosis (HP:0002605)2.50558102
42Progressive cerebellar ataxia (HP:0002073)2.44131918
43Progressive macrocephaly (HP:0004481)2.41824623
44Optic nerve coloboma (HP:0000588)2.40604290
45Abnormal drinking behavior (HP:0030082)2.37023718
46Polydipsia (HP:0001959)2.37023718
47Abnormality of the renal cortex (HP:0011035)2.34762022
48Pallor (HP:0000980)2.32006110
49Acute encephalopathy (HP:0006846)2.31684688
50Anencephaly (HP:0002323)2.30382489
51Tubular atrophy (HP:0000092)2.30037715
52Ectopic kidney (HP:0000086)2.28226584
53Macrocytic anemia (HP:0001972)2.28126382
54Flat capital femoral epiphysis (HP:0003370)2.27434553
55Impaired vibration sensation in the lower limbs (HP:0002166)2.22085289
56Scrotal hypoplasia (HP:0000046)2.21115443
57Abnormal number of erythroid precursors (HP:0012131)2.20975209
58Retinal dysplasia (HP:0007973)2.19725697
59Abnormal hair whorl (HP:0010721)2.19067748
60Polyphagia (HP:0002591)2.18872627
61Esotropia (HP:0000565)2.14719309
62Tubulointerstitial fibrosis (HP:0005576)2.10736511
63Rectal prolapse (HP:0002035)2.10513446
64Hyperphosphatemia (HP:0002905)2.08647881
65Neoplasm of the adrenal cortex (HP:0100641)2.08273885
66Hepatoblastoma (HP:0002884)2.07977273
67Enlarged penis (HP:0000040)2.06394353
68Bony spicule pigmentary retinopathy (HP:0007737)2.06260859
69Congenital stationary night blindness (HP:0007642)2.05512335
70Hypogonadotrophic hypogonadism (HP:0000044)2.05366556
71Abnormality of the corticospinal tract (HP:0002492)2.04390015
72Abnormality of cochlea (HP:0000375)2.03535351
73Adrenal hypoplasia (HP:0000835)2.03405003
74Oligodontia (HP:0000677)2.01857862
75Oligodactyly (hands) (HP:0001180)1.99845868
76Abnormal cartilage morphology (HP:0002763)1.97636250
77Mitochondrial inheritance (HP:0001427)1.96518583
78Tubulointerstitial abnormality (HP:0001969)1.95996824
79Parakeratosis (HP:0001036)1.92791922
80Abnormal number of incisors (HP:0011064)1.91394085
81Intestinal atresia (HP:0011100)1.89803069
82Prolonged QT interval (HP:0001657)1.89620573
83Abnormality of the aortic arch (HP:0012303)1.88010054
84Dynein arm defect of respiratory motile cilia (HP:0012255)1.85675883
85Absent/shortened dynein arms (HP:0200106)1.85675883
86Broad-based gait (HP:0002136)1.84069691
87Down-sloping shoulders (HP:0200021)1.83145657
88Constricted visual fields (HP:0001133)1.82297427
89Reticulocytopenia (HP:0001896)1.81492715
90Potter facies (HP:0002009)1.81441657
91Facial shape deformation (HP:0011334)1.81441657
92Abnormality of the labia minora (HP:0012880)1.80897625
93Abnormality of the 4th metacarpal (HP:0010012)1.79473551
94Anterior segment dysgenesis (HP:0007700)1.79144329
95Glossoptosis (HP:0000162)1.78685419
96Degeneration of the lateral corticospinal tracts (HP:0002314)1.77329051
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77329051
98Congenital hepatic fibrosis (HP:0002612)1.76268899
99Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75456098
100Short 4th metacarpal (HP:0010044)1.75456098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.71009069
2CAMKK24.10000077
3CAMKK13.45361658
4PRKD32.68785031
5PINK12.53358216
6DYRK22.31203655
7MAP3K121.98243829
8TIE11.89048578
9DAPK21.87835155
10DYRK1B1.76179628
11ZAK1.74504975
12NTRK21.69605669
13WNK41.67987828
14MAP3K41.66794798
15KSR11.62438709
16PRKCH1.59232222
17WNK31.55203596
18CDK191.52421830
19MARK11.52135345
20CAMK11.50664890
21BMPR1B1.46723513
22CAMK1D1.44427342
23MAPK131.37809537
24STK111.36389884
25TYRO31.36332911
26PDK21.35662895
27MINK11.31996380
28PAK31.31563673
29ADRBK21.26761195
30MAP3K111.26307376
31PRKD21.25578359
32NME11.25169939
33PNCK1.19969928
34OBSCN1.17069595
35MKNK21.15207379
36CAMK1G1.14756446
37PRKCG1.14600154
38NTRK31.13791936
39BRSK11.12238814
40PLK41.10965050
41PRKCZ1.09426024
42RPS6KA21.09184451
43CAMK41.06870803
44LRRK21.06553962
45MAP2K71.05175401
46RPS6KA61.03763038
47DYRK1A1.03686734
48ERBB21.03046093
49MAP2K40.99210652
50BCR0.95996595
51GRK10.94917810
52ATR0.90928407
53RPS6KL10.89872846
54RPS6KC10.89872846
55FRK0.88337664
56ADRBK10.87534462
57NUAK10.86102612
58PRKACA0.84972427
59NEK20.84009749
60CSNK1G20.79162653
61ICK0.74689132
62UHMK10.74065583
63CDC70.73191279
64SGK10.70015374
65CDK50.69909573
66WNK10.68500931
67OXSR10.67792024
68MAP2K20.67556140
69CHEK20.67101688
70MAP3K70.66794790
71CSNK1E0.60968353
72NTRK10.60235594
73ABL20.59565911
74INSRR0.59173365
75CSNK1D0.58695238
76AKT10.56204463
77PHKG10.54998835
78PHKG20.54998835
79PIK3CA0.53892313
80GRK50.53198927
81PRKCA0.53022395
82PRKACG0.51299457
83EPHA40.48965632
84PKN10.48526647
85CSNK1G30.48183973
86SIK20.47400999
87SGK4940.46973351
88SGK2230.46973351
89MAPK110.46573038
90PRKAA10.46066765
91RPS6KA10.44118013
92DYRK30.43587013
93PRKDC0.42756381
94PRKCQ0.42535670
95CSNK2A20.42388531
96CDK140.42225064
97NME20.40856002
98MAPK10.39700258
99MAPK150.38800391
100RPS6KA30.38740513

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.04818589
2Parkinsons disease_Homo sapiens_hsa050122.91353798
3Nicotine addiction_Homo sapiens_hsa050332.85987028
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.85930567
5Sulfur relay system_Homo sapiens_hsa041222.69735048
6Oxidative phosphorylation_Homo sapiens_hsa001902.69692603
7Linoleic acid metabolism_Homo sapiens_hsa005912.65747302
8RNA polymerase_Homo sapiens_hsa030202.55491249
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.47813938
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45603722
11Morphine addiction_Homo sapiens_hsa050322.22334915
12Ether lipid metabolism_Homo sapiens_hsa005652.10111456
13Cardiac muscle contraction_Homo sapiens_hsa042602.09638177
14Hedgehog signaling pathway_Homo sapiens_hsa043402.00760067
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96163174
16GABAergic synapse_Homo sapiens_hsa047271.89779918
17Circadian entrainment_Homo sapiens_hsa047131.86338382
18Axon guidance_Homo sapiens_hsa043601.83846568
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.81181814
20Huntingtons disease_Homo sapiens_hsa050161.78121961
21Insulin secretion_Homo sapiens_hsa049111.73538094
22Regulation of autophagy_Homo sapiens_hsa041401.71566804
23Fat digestion and absorption_Homo sapiens_hsa049751.70852309
24Base excision repair_Homo sapiens_hsa034101.66290752
25Alzheimers disease_Homo sapiens_hsa050101.62094659
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58355510
27Basal cell carcinoma_Homo sapiens_hsa052171.56180509
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51761400
29Glutamatergic synapse_Homo sapiens_hsa047241.50023896
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49515290
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46458286
32One carbon pool by folate_Homo sapiens_hsa006701.29211144
33Ovarian steroidogenesis_Homo sapiens_hsa049131.28082290
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.22337185
35Pancreatic secretion_Homo sapiens_hsa049721.17973874
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17353830
37Cocaine addiction_Homo sapiens_hsa050301.15202163
38Steroid biosynthesis_Homo sapiens_hsa001001.14986756
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07855553
40Cholinergic synapse_Homo sapiens_hsa047251.06581383
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05446109
42Oxytocin signaling pathway_Homo sapiens_hsa049211.04971340
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01506735
44Gastric acid secretion_Homo sapiens_hsa049710.99164305
45Salivary secretion_Homo sapiens_hsa049700.95502152
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94967209
47Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94602805
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93469782
49Butanoate metabolism_Homo sapiens_hsa006500.93086141
50Purine metabolism_Homo sapiens_hsa002300.92744016
51Mismatch repair_Homo sapiens_hsa034300.92638158
52Dilated cardiomyopathy_Homo sapiens_hsa054140.91352249
53Bile secretion_Homo sapiens_hsa049760.91244179
54Folate biosynthesis_Homo sapiens_hsa007900.90154863
55Dopaminergic synapse_Homo sapiens_hsa047280.89834084
56Nitrogen metabolism_Homo sapiens_hsa009100.89567243
57Amphetamine addiction_Homo sapiens_hsa050310.88423093
58Arachidonic acid metabolism_Homo sapiens_hsa005900.87239802
59Synaptic vesicle cycle_Homo sapiens_hsa047210.81942131
60Alcoholism_Homo sapiens_hsa050340.81767206
61Serotonergic synapse_Homo sapiens_hsa047260.78429500
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77304284
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75295625
64Phototransduction_Homo sapiens_hsa047440.72188195
65Ras signaling pathway_Homo sapiens_hsa040140.71344397
66Propanoate metabolism_Homo sapiens_hsa006400.68744524
67Melanogenesis_Homo sapiens_hsa049160.68205378
68Olfactory transduction_Homo sapiens_hsa047400.66382432
69cAMP signaling pathway_Homo sapiens_hsa040240.65497272
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64158479
71Thyroid hormone synthesis_Homo sapiens_hsa049180.61662160
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58642489
73Pyrimidine metabolism_Homo sapiens_hsa002400.58306593
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52170092
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51426207
76Calcium signaling pathway_Homo sapiens_hsa040200.45992611
77Metabolic pathways_Homo sapiens_hsa011000.45717006
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.43920006
79Gap junction_Homo sapiens_hsa045400.43594797
80Taste transduction_Homo sapiens_hsa047420.42075075
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41861991
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40569679
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39007905
84Arginine and proline metabolism_Homo sapiens_hsa003300.38341155
85Fanconi anemia pathway_Homo sapiens_hsa034600.38243071
86Retinol metabolism_Homo sapiens_hsa008300.37828118
87Glycerolipid metabolism_Homo sapiens_hsa005610.37451414
88RNA transport_Homo sapiens_hsa030130.31273689
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29910582
90Basal transcription factors_Homo sapiens_hsa030220.29863918
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28877668
92Peroxisome_Homo sapiens_hsa041460.28196717
93Renin secretion_Homo sapiens_hsa049240.27975836
94Hippo signaling pathway_Homo sapiens_hsa043900.27770317
95Melanoma_Homo sapiens_hsa052180.25731767
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22798368
97Pathways in cancer_Homo sapiens_hsa052000.22678233
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.21565124
99Starch and sucrose metabolism_Homo sapiens_hsa005000.21028194
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.20911626

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