USP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.16167588
2synaptic vesicle maturation (GO:0016188)6.12804947
3pyrimidine nucleobase catabolic process (GO:0006208)5.77972519
4locomotory exploration behavior (GO:0035641)5.72852336
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.56799830
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.41853819
7vocalization behavior (GO:0071625)5.35752396
8synaptic vesicle exocytosis (GO:0016079)5.30016320
9establishment of mitochondrion localization (GO:0051654)5.21436463
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.20555104
11glutamate secretion (GO:0014047)5.08885795
12synaptic vesicle docking involved in exocytosis (GO:0016081)5.03565232
13regulation of glutamate receptor signaling pathway (GO:1900449)5.01970168
14regulation of synaptic vesicle exocytosis (GO:2000300)4.91738527
15protein localization to synapse (GO:0035418)4.69677296
16nucleobase catabolic process (GO:0046113)4.66766435
17neuron cell-cell adhesion (GO:0007158)4.64894015
18neurotransmitter secretion (GO:0007269)4.62054036
19exploration behavior (GO:0035640)4.57636992
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.53746638
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.49827794
22regulation of synaptic vesicle transport (GO:1902803)4.42130270
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.40154988
24regulation of neuronal synaptic plasticity (GO:0048168)4.35022896
25layer formation in cerebral cortex (GO:0021819)4.26057084
26neurotransmitter-gated ion channel clustering (GO:0072578)4.07073030
27synaptic transmission, glutamatergic (GO:0035249)4.06932613
28regulation of synapse structural plasticity (GO:0051823)4.05571759
29glutamate receptor signaling pathway (GO:0007215)4.00586765
30establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.96397014
31mitochondrion transport along microtubule (GO:0047497)3.96397014
32dendritic spine morphogenesis (GO:0060997)3.95077533
33positive regulation of synaptic transmission, GABAergic (GO:0032230)3.91586940
34neuron-neuron synaptic transmission (GO:0007270)3.89647463
35neuronal action potential propagation (GO:0019227)3.87582356
36long-term memory (GO:0007616)3.84529026
37gamma-aminobutyric acid transport (GO:0015812)3.83760015
38cell migration in hindbrain (GO:0021535)3.80765836
39positive regulation of synapse maturation (GO:0090129)3.76174205
40neurotransmitter transport (GO:0006836)3.74686735
41proline transport (GO:0015824)3.72833903
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71945934
43postsynaptic membrane organization (GO:0001941)3.63336220
44neuron recognition (GO:0008038)3.62222423
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59063576
46positive regulation of membrane potential (GO:0045838)3.57508493
47activation of protein kinase A activity (GO:0034199)3.57230023
48synaptic vesicle endocytosis (GO:0048488)3.56785709
49regulation of postsynaptic membrane potential (GO:0060078)3.46864677
50regulation of neurotransmitter levels (GO:0001505)3.46863325
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.46265648
52auditory behavior (GO:0031223)3.45196607
53regulation of synaptic plasticity (GO:0048167)3.43634207
54neuromuscular process controlling posture (GO:0050884)3.43184418
55axonal fasciculation (GO:0007413)3.41549093
56cerebellar Purkinje cell differentiation (GO:0021702)3.40205977
57negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.38976575
58cellular potassium ion homeostasis (GO:0030007)3.37894122
59long-term synaptic potentiation (GO:0060291)3.36616708
60response to histamine (GO:0034776)3.35092223
61response to auditory stimulus (GO:0010996)3.34432273
62neuromuscular process controlling balance (GO:0050885)3.33849354
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.33501469
64transmission of nerve impulse (GO:0019226)3.31360284
65behavioral fear response (GO:0001662)3.29496142
66behavioral defense response (GO:0002209)3.29496142
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.29281347
68neuromuscular synaptic transmission (GO:0007274)3.27961221
69positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.27821731
70regulation of dendritic spine morphogenesis (GO:0061001)3.26984778
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.26481608
72regulation of neurotransmitter secretion (GO:0046928)3.25969152
73negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25129741
74sodium ion export (GO:0071436)3.23091936
75presynaptic membrane assembly (GO:0097105)3.22657865
76regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.22577907
77neuronal ion channel clustering (GO:0045161)3.22049693
78positive regulation of synapse assembly (GO:0051965)3.21082776
79positive regulation of neurotransmitter transport (GO:0051590)3.19177464
80dendritic spine organization (GO:0097061)3.15260175
81regulation of synaptic transmission, GABAergic (GO:0032228)3.14283604
82G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.14205851
83prepulse inhibition (GO:0060134)3.13268320
84regulation of neurotransmitter transport (GO:0051588)3.11612283
85positive regulation of neurotransmitter secretion (GO:0001956)3.11376921
86synaptic vesicle transport (GO:0048489)3.10109013
87establishment of synaptic vesicle localization (GO:0097480)3.10109013
88regulation of vesicle fusion (GO:0031338)3.06066018
89positive regulation of mitochondrial fission (GO:0090141)3.06050449
90learning (GO:0007612)3.05854973
91dendrite morphogenesis (GO:0048813)3.04684452
92innervation (GO:0060384)3.04223366
93startle response (GO:0001964)3.01660420
94presynaptic membrane organization (GO:0097090)3.01569306
95fear response (GO:0042596)3.01407896
96positive regulation of synaptic transmission (GO:0050806)3.01317329
97synapse assembly (GO:0007416)3.00246504
98vesicle transport along microtubule (GO:0047496)2.99986353
99membrane hyperpolarization (GO:0060081)2.98843661
100G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97034795
101mechanosensory behavior (GO:0007638)2.96328640
102regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96006452
103neuromuscular process (GO:0050905)2.94476585
104regulation of synaptic transmission (GO:0050804)2.94398551
105regulation of respiratory system process (GO:0044065)2.94069430
106membrane depolarization (GO:0051899)2.93425206
107intraspecies interaction between organisms (GO:0051703)2.93374657
108social behavior (GO:0035176)2.93374657
109positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.93041347
110cell communication by electrical coupling (GO:0010644)2.92686379
111synapse organization (GO:0050808)2.91882407
112membrane depolarization during action potential (GO:0086010)2.90059066
113cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.90015725
114positive regulation of dendritic spine morphogenesis (GO:0061003)2.89932212
115striatum development (GO:0021756)2.87585931
116hippocampus development (GO:0021766)2.85749764
117establishment of vesicle localization (GO:0051650)2.82839868
118cerebellar granule cell differentiation (GO:0021707)2.82615578
119glycosphingolipid biosynthetic process (GO:0006688)2.82238664
120regulation of voltage-gated calcium channel activity (GO:1901385)2.80664158
121negative regulation of microtubule polymerization (GO:0031115)2.77132141
122cerebellar Purkinje cell layer development (GO:0021680)2.75835146
123calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.74659580
124adult walking behavior (GO:0007628)2.73667387
125organelle transport along microtubule (GO:0072384)2.69941264
126regulation of synapse maturation (GO:0090128)2.67475388
127acidic amino acid transport (GO:0015800)2.66929240
128axon cargo transport (GO:0008088)2.66235714
129neurofilament cytoskeleton organization (GO:0060052)2.65984828
130central nervous system projection neuron axonogenesis (GO:0021952)2.62714811
131positive regulation of dendritic spine development (GO:0060999)2.60785719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.59780497
2GBX2_23144817_ChIP-Seq_PC3_Human3.63241217
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10601316
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09213039
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95339655
6REST_21632747_ChIP-Seq_MESCs_Mouse2.89097562
7* RARB_27405468_Chip-Seq_BRAIN_Mouse2.87973691
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.81655394
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65065152
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65065152
11DROSHA_22980978_ChIP-Seq_HELA_Human2.64491561
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62865752
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.57817335
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.56149502
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50486881
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50153929
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.46346049
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46311577
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39874970
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39803253
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.38331934
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36009227
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.28305512
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.24498862
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.23868252
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.18917681
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14997232
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13111109
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12169001
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05198536
31AR_21572438_ChIP-Seq_LNCaP_Human1.94668445
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.92667211
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85823024
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78336940
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61077283
36SMAD4_21799915_ChIP-Seq_A2780_Human1.60565024
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59901963
38* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48769891
39TAF15_26573619_Chip-Seq_HEK293_Human1.47763332
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.46988449
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.41340923
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39873762
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38542280
44RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37733134
45FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.36765048
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36337250
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.35399668
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35058066
49* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34834847
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.32430186
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32216740
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31866657
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30147703
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29583163
55CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.28978832
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.28850745
57P300_19829295_ChIP-Seq_ESCs_Human1.28147907
58AR_19668381_ChIP-Seq_PC3_Human1.28128759
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27997164
60SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27870036
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.26193783
62FUS_26573619_Chip-Seq_HEK293_Human1.24194470
63YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23880584
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23004270
65* ZNF274_21170338_ChIP-Seq_K562_Hela1.22312449
66STAT3_23295773_ChIP-Seq_U87_Human1.21757322
67RNF2_27304074_Chip-Seq_NSC_Mouse1.21023451
68IGF1R_20145208_ChIP-Seq_DFB_Human1.20712279
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.20319431
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17520465
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15409149
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15023247
73AR_25329375_ChIP-Seq_VCAP_Human1.14637687
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13785625
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11840781
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11798508
77* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11574080
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11549107
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10994126
80GATA1_26923725_Chip-Seq_HPCs_Mouse1.10360283
81ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10222417
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10097062
83DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08943906
84TCF4_23295773_ChIP-Seq_U87_Human1.08854056
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07481012
86* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07385135
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06573473
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06572987
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05255314
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05171813
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04498084
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03946717
93SMAD3_21741376_ChIP-Seq_ESCs_Human1.03621280
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02756442
95KDM2B_26808549_Chip-Seq_K562_Human1.02568402
96TET1_21490601_ChIP-Seq_MESCs_Mouse1.01997701
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00027795
98* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98927160
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.98764479
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97660240
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.95968226
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93213603
103E2F1_17053090_ChIP-ChIP_MCF-7_Human0.93155362
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92880681
105SOX9_26525672_Chip-Seq_HEART_Mouse0.92790543
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92573538
107POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91824199
108RUNX2_22187159_ChIP-Seq_PCA_Human0.91456447
109PIAS1_25552417_ChIP-Seq_VCAP_Human0.91391607
110YY1_21170310_ChIP-Seq_MESCs_Mouse0.89814063
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89756304
112POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87744089
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87371659
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87371659
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87184593
116REST_19997604_ChIP-ChIP_NEURONS_Mouse0.87161151
117CTCF_27219007_Chip-Seq_Bcells_Human0.86739926
118OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86638000
119AHR_22903824_ChIP-Seq_MCF-7_Human0.86311482
120TP53_16413492_ChIP-PET_HCT116_Human0.85575303
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85339240
122PRDM14_20953172_ChIP-Seq_ESCs_Human0.84950806
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84258030
124ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83207343
125TP53_20018659_ChIP-ChIP_R1E_Mouse0.81782693
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81695452
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81576174
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81408279
129SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79575418
130IRF1_19129219_ChIP-ChIP_H3396_Human0.79460176
131* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.78944184
132POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.78475429
133SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.77359349
134NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.76345677
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75135997
136POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.74536776
137GABP_19822575_ChIP-Seq_HepG2_Human0.72794990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.06653860
2MP0003880_abnormal_central_pattern4.68771375
3MP0003635_abnormal_synaptic_transmissio4.03085190
4MP0009745_abnormal_behavioral_response3.29670802
5MP0002063_abnormal_learning/memory/cond3.20708676
6MP0004270_analgesia3.15628944
7MP0002064_seizures3.05067446
8MP0009046_muscle_twitch2.97456877
9MP0005423_abnormal_somatic_nervous2.97437260
10MP0003122_maternal_imprinting2.87972994
11MP0001968_abnormal_touch/_nociception2.76521868
12MP0002572_abnormal_emotion/affect_behav2.73908168
13MP0002822_catalepsy2.49937035
14MP0003787_abnormal_imprinting2.47151541
15MP0001486_abnormal_startle_reflex2.43571567
16MP0002272_abnormal_nervous_system2.37579513
17MP0002734_abnormal_mechanical_nocicepti2.33770520
18MP0001501_abnormal_sleep_pattern2.08936219
19MP0002736_abnormal_nociception_after2.03255177
20MP0005646_abnormal_pituitary_gland1.99296840
21MP0001440_abnormal_grooming_behavior1.92077605
22MP0009780_abnormal_chondrocyte_physiolo1.87248165
23MP0000778_abnormal_nervous_system1.84160268
24MP0002067_abnormal_sensory_capabilities1.83794613
25MP0002733_abnormal_thermal_nociception1.82225215
26MP0002557_abnormal_social/conspecific_i1.80318924
27MP0004811_abnormal_neuron_physiology1.78755575
28MP0002184_abnormal_innervation1.75914415
29MP0001970_abnormal_pain_threshold1.75857262
30MP0008569_lethality_at_weaning1.75140696
31MP0002102_abnormal_ear_morphology1.71844130
32MP0005386_behavior/neurological_phenoty1.70385943
33MP0004924_abnormal_behavior1.70385943
34MP0002735_abnormal_chemical_nociception1.70280154
35MP0003121_genomic_imprinting1.66982004
36MP0003123_paternal_imprinting1.65762532
37MP0008789_abnormal_olfactory_epithelium1.64096696
38MP0006276_abnormal_autonomic_nervous1.63479474
39MP0004858_abnormal_nervous_system1.63242312
40MP0002909_abnormal_adrenal_gland1.62393374
41MP0005645_abnormal_hypothalamus_physiol1.62304341
42MP0000955_abnormal_spinal_cord1.61274204
43MP0001529_abnormal_vocalization1.54983276
44MP0004885_abnormal_endolymph1.52939522
45MP0002882_abnormal_neuron_morphology1.43019001
46MP0001188_hyperpigmentation1.39386822
47MP0001502_abnormal_circadian_rhythm1.38163417
48MP0002066_abnormal_motor_capabilities/c1.37255111
49MP0003283_abnormal_digestive_organ1.34148180
50MP0001984_abnormal_olfaction1.32498496
51MP0000569_abnormal_digit_pigmentation1.31857045
52MP0002152_abnormal_brain_morphology1.26491296
53MP0004142_abnormal_muscle_tone1.26307515
54MP0003329_amyloid_beta_deposits1.24094434
55MP0003879_abnormal_hair_cell1.22538991
56MP0001905_abnormal_dopamine_level1.22018958
57MP0000631_abnormal_neuroendocrine_gland1.14764684
58MP0003633_abnormal_nervous_system1.12712865
59MP0003938_abnormal_ear_development1.05406482
60MP0008877_abnormal_DNA_methylation1.05239710
61MP0000049_abnormal_middle_ear1.00391295
62MP0000566_synostosis0.96718694
63MP0003631_nervous_system_phenotype0.95149865
64MP0004233_abnormal_muscle_weight0.92845388
65MP0008961_abnormal_basal_metabolism0.91936242
66MP0002069_abnormal_eating/drinking_beha0.91478168
67MP0005394_taste/olfaction_phenotype0.91115679
68MP0005499_abnormal_olfactory_system0.91115679
69MP0000751_myopathy0.90128447
70MP0000026_abnormal_inner_ear0.88372917
71MP0005253_abnormal_eye_physiology0.86988915
72MP0001177_atelectasis0.86969301
73MP0002229_neurodegeneration0.86665994
74MP0005551_abnormal_eye_electrophysiolog0.85305727
75MP0008872_abnormal_physiological_respon0.85279957
76MP0003861_abnormal_nervous_system0.84688180
77MP0002653_abnormal_ependyma_morphology0.84260878
78MP0008874_decreased_physiological_sensi0.80415946
79MP0002249_abnormal_larynx_morphology0.79350556
80MP0004147_increased_porphyrin_level0.79290822
81MP0002752_abnormal_somatic_nervous0.78139049
82MP0005409_darkened_coat_color0.77711403
83MP0003634_abnormal_glial_cell0.77132021
84MP0006292_abnormal_olfactory_placode0.74621089
85MP0005623_abnormal_meninges_morphology0.73631997
86MP0001986_abnormal_taste_sensitivity0.72009192
87MP0001963_abnormal_hearing_physiology0.71360407
88MP0002638_abnormal_pupillary_reflex0.70694389
89MP0003632_abnormal_nervous_system0.70649949
90MP0004145_abnormal_muscle_electrophysio0.69640253
91MP0004085_abnormal_heartbeat0.69297582
92MP0000013_abnormal_adipose_tissue0.69013028
93MP0002234_abnormal_pharynx_morphology0.68753724
94MP0002233_abnormal_nose_morphology0.68348158
95MP0005187_abnormal_penis_morphology0.68104282
96MP0001943_abnormal_respiration0.67906894
97MP0006072_abnormal_retinal_apoptosis0.66701788
98MP0003119_abnormal_digestive_system0.65144129
99MP0000534_abnormal_ureter_morphology0.65081646
100MP0010769_abnormal_survival0.64128306
101MP0002082_postnatal_lethality0.63242992
102MP0010770_preweaning_lethality0.63242992
103MP0001270_distended_abdomen0.63011675
104MP0000920_abnormal_myelination0.62631168
105MP0005171_absent_coat_pigmentation0.62555751
106MP0010768_mortality/aging0.60829370
107MP0002751_abnormal_autonomic_nervous0.59263476
108MP0001485_abnormal_pinna_reflex0.58658855
109MP0001299_abnormal_eye_distance/0.58155788
110MP0002081_perinatal_lethality0.58151779
111MP0003690_abnormal_glial_cell0.56906368
112MP0003137_abnormal_impulse_conducting0.54156537
113MP0003956_abnormal_body_size0.51562623
114MP0004215_abnormal_myocardial_fiber0.51470079
115MP0004742_abnormal_vestibular_system0.50883869
116MP0002089_abnormal_postnatal_growth/wei0.48225169
117MP0004133_heterotaxia0.48157825

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.70124877
2Myokymia (HP:0002411)5.40523557
3Focal seizures (HP:0007359)5.17303536
4Visual hallucinations (HP:0002367)4.82797730
5Epileptic encephalopathy (HP:0200134)4.49769794
6Atonic seizures (HP:0010819)3.91777263
7Febrile seizures (HP:0002373)3.77781487
8Absence seizures (HP:0002121)3.72077468
9Progressive cerebellar ataxia (HP:0002073)3.68339873
10Dialeptic seizures (HP:0011146)3.36164592
11Generalized tonic-clonic seizures (HP:0002069)3.21472780
12Ankle clonus (HP:0011448)3.19326493
13Broad-based gait (HP:0002136)3.18232993
14Impaired vibration sensation in the lower limbs (HP:0002166)3.13976932
15Depression (HP:0000716)3.12350003
16Urinary bladder sphincter dysfunction (HP:0002839)3.09513087
17Retinal dysplasia (HP:0007973)3.09455091
18Supranuclear gaze palsy (HP:0000605)2.99503367
19Poor eye contact (HP:0000817)2.93820886
20Action tremor (HP:0002345)2.91862150
21Gait imbalance (HP:0002141)2.91577413
22Cerebral hypomyelination (HP:0006808)2.91402595
23Truncal ataxia (HP:0002078)2.91307220
24Postural instability (HP:0002172)2.86004757
25Abnormal eating behavior (HP:0100738)2.85184712
26Cortical dysplasia (HP:0002539)2.83856987
27Hyperventilation (HP:0002883)2.81105207
28Genetic anticipation (HP:0003743)2.78868994
29Dysdiadochokinesis (HP:0002075)2.77518473
30Gaze-evoked nystagmus (HP:0000640)2.71919962
31Peripheral hypomyelination (HP:0007182)2.71915882
32Lissencephaly (HP:0001339)2.71369380
33Abnormal social behavior (HP:0012433)2.68871577
34Impaired social interactions (HP:0000735)2.68871577
35Mutism (HP:0002300)2.63826494
36Excessive salivation (HP:0003781)2.61880186
37Drooling (HP:0002307)2.61880186
38Impaired smooth pursuit (HP:0007772)2.60393747
39Papilledema (HP:0001085)2.58469946
40Split foot (HP:0001839)2.56206422
41Urinary urgency (HP:0000012)2.51696776
42Anxiety (HP:0000739)2.51271561
43Aplasia/Hypoplasia of the brainstem (HP:0007362)2.51245950
44Hypoplasia of the brainstem (HP:0002365)2.51245950
45Abnormality of the lower motor neuron (HP:0002366)2.48670636
46Dysmetria (HP:0001310)2.46462443
47Diplopia (HP:0000651)2.45181450
48Abnormality of binocular vision (HP:0011514)2.45181450
49Pointed chin (HP:0000307)2.43197083
50Progressive inability to walk (HP:0002505)2.42016518
51Sleep apnea (HP:0010535)2.39061115
52Spastic tetraplegia (HP:0002510)2.38563471
53Limb dystonia (HP:0002451)2.35842779
54Abnormality of ocular smooth pursuit (HP:0000617)2.34386407
55Spastic gait (HP:0002064)2.33355883
56Bradykinesia (HP:0002067)2.32939085
57Hemiparesis (HP:0001269)2.30982176
58Congenital primary aphakia (HP:0007707)2.29472081
59Nephrogenic diabetes insipidus (HP:0009806)2.29427241
60Amblyopia (HP:0000646)2.28690648
61Stereotypic behavior (HP:0000733)2.27689556
62Insomnia (HP:0100785)2.24368181
63Hemiplegia (HP:0002301)2.23726361
64Polyphagia (HP:0002591)2.22375090
65Scanning speech (HP:0002168)2.22353682
66Poor suck (HP:0002033)2.21876874
67Epileptiform EEG discharges (HP:0011182)2.20096263
68Torticollis (HP:0000473)2.18947661
69Annular pancreas (HP:0001734)2.18122525
70CNS hypomyelination (HP:0003429)2.18122304
71Atrophy/Degeneration involving motor neurons (HP:0007373)2.18101136
72Pachygyria (HP:0001302)2.17233831
73Absent speech (HP:0001344)2.17080532
74Medial flaring of the eyebrow (HP:0010747)2.17031140
75Amyotrophic lateral sclerosis (HP:0007354)2.12254481
76EEG with generalized epileptiform discharges (HP:0011198)2.11269593
77Esotropia (HP:0000565)2.06050227
78Hypsarrhythmia (HP:0002521)2.05243743
79Generalized hypotonia (HP:0001290)2.03795421
80Abnormality of the corticospinal tract (HP:0002492)2.03699271
81Protruding tongue (HP:0010808)2.03403762
82Delusions (HP:0000746)2.01348757
83Hand muscle atrophy (HP:0009130)2.00380525
84Hypoventilation (HP:0002791)1.98820524
85Focal dystonia (HP:0004373)1.97885841
86Type II lissencephaly (HP:0007260)1.97521881
87Hypoplasia of the corpus callosum (HP:0002079)1.97216084
88Dysmetric saccades (HP:0000641)1.97195163
89Lower limb muscle weakness (HP:0007340)1.96614211
90Impaired vibratory sensation (HP:0002495)1.95965758
91Pheochromocytoma (HP:0002666)1.95840775
92Akinesia (HP:0002304)1.95801940
93Agitation (HP:0000713)1.95665140
94Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94833913
95Abnormality of the labia minora (HP:0012880)1.94578724
96Vaginal atresia (HP:0000148)1.91627771
97Neoplasm of the heart (HP:0100544)1.88493203
98Megalencephaly (HP:0001355)1.88359028
99Morphological abnormality of the pyramidal tract (HP:0002062)1.86962712
100Genital tract atresia (HP:0001827)1.86758765
101Abnormal hair whorl (HP:0010721)1.84508486
102Inability to walk (HP:0002540)1.84084001
103Termporal pattern (HP:0011008)1.83848330
104Insidious onset (HP:0003587)1.83848330
105Failure to thrive in infancy (HP:0001531)1.83772738
106Macroorchidism (HP:0000053)1.83623339
107Shoulder girdle muscle weakness (HP:0003547)1.82516358
108Intention tremor (HP:0002080)1.82362487
109Muscular hypotonia of the trunk (HP:0008936)1.81886984
110Hyperacusis (HP:0010780)1.81491648
111Inappropriate behavior (HP:0000719)1.81027217
112Fetal akinesia sequence (HP:0001989)1.80804853
113Heterochromia iridis (HP:0001100)1.80027192
114Neuronal loss in central nervous system (HP:0002529)1.78302482
115Cholecystitis (HP:0001082)1.77046302
116Abnormal gallbladder physiology (HP:0012438)1.77046302
117Ankyloglossia (HP:0010296)1.77030632
118Occipital encephalocele (HP:0002085)1.76499428
119Neoplasm of the peripheral nervous system (HP:0100007)1.75014507
120Open mouth (HP:0000194)1.74975879
121Craniofacial dystonia (HP:0012179)1.74730310
122Macroglossia (HP:0000158)1.74194228
123Specific learning disability (HP:0001328)1.74012070
124Autism (HP:0000717)1.73799112
125Neurofibrillary tangles (HP:0002185)1.72346206
126Neuroendocrine neoplasm (HP:0100634)1.71881331
127Status epilepticus (HP:0002133)1.71555346
128Resting tremor (HP:0002322)1.70879761
129Psychosis (HP:0000709)1.69955197
130Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69867529
131Degeneration of the lateral corticospinal tracts (HP:0002314)1.69867529
132Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68924262
133Gait ataxia (HP:0002066)1.68812492
134Menstrual irregularities (HP:0000858)1.67780026
135Cerebral inclusion bodies (HP:0100314)1.67583611
136Generalized myoclonic seizures (HP:0002123)1.67471610
137Aqueductal stenosis (HP:0002410)1.67251042
138Ulnar claw (HP:0001178)1.66575577
139Optic nerve hypoplasia (HP:0000609)1.63632882
140Unsteady gait (HP:0002317)1.63546138
141Emotional lability (HP:0000712)1.63231491
142Humeroradial synostosis (HP:0003041)1.62905610
143Synostosis involving the elbow (HP:0003938)1.62905610

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.77900218
2EPHA43.71589829
3MAP3K93.61676303
4MAP3K43.21000869
5MARK13.04307587
6MINK12.72053281
7MAP3K122.64801415
8MAP2K72.57431977
9TNIK2.51432519
10NTRK22.50520694
11MAP4K22.37408183
12BCR2.28075309
13DYRK22.25444646
14CASK2.22798376
15PAK62.17283114
16DAPK21.99863646
17MAP2K41.97862537
18TRIM281.88633260
19KSR11.86258753
20CSNK1A1L1.85519975
21KSR21.82118846
22PRKD31.77804627
23CDK191.68314401
24BCKDK1.61488637
25MAPK131.58791673
26DAPK11.58505678
27CAMKK11.57018519
28CSNK1G11.52656649
29NTRK11.51981217
30CDK51.47725995
31UHMK11.46178779
32PNCK1.44516868
33WNK31.39621492
34PLK21.38768547
35FES1.34481814
36PRPF4B1.31644899
37SIK21.30193299
38SRPK11.19031639
39LIMK11.16950157
40TESK11.12543491
41CDK181.09723892
42TYRO31.09055503
43CDK151.06971033
44MAP3K131.06788993
45STK381.06014791
46PRKCG1.05453059
47RIPK41.04234569
48EPHA31.01718193
49CDK141.01530863
50ARAF1.00551883
51CCNB10.96145258
52CDK11A0.96029436
53LATS20.95078161
54GRK50.94898762
55CAMK10.93233634
56TESK20.92175293
57RAF10.89977927
58PRKCH0.88663704
59PKN10.87051477
60CSNK1G20.85509872
61SGK2230.83538959
62SGK4940.83538959
63ALK0.82090799
64RET0.82022864
65CAMK2A0.81894588
66TAOK10.80882386
67TNK20.79961927
68MAP3K60.79117539
69MARK20.76242409
70PHKG10.74760044
71PHKG20.74760044
72SGK20.74415027
73STK110.74013307
74CAMKK20.73497053
75NEK10.72663242
76PAK30.71922516
77SCYL20.71490783
78SGK30.70566995
79BRSK10.70265424
80DYRK1A0.69129226
81CAMK2G0.67944615
82EEF2K0.63106957
83SGK10.60906082
84DYRK1B0.59662741
85CAMK2B0.58561072
86TSSK60.58128705
87CAMK1G0.57614353
88CDC42BPA0.56927755
89SIK30.55306180
90AKT30.55255738
91ERBB30.55094528
92MAPK100.50425251
93MAP3K110.50139462
94RPS6KA30.50092362
95LMTK20.50035172
96CAMK40.49633909
97MAP3K20.49256802
98RPS6KA20.48056674
99PINK10.44313191
100CSNK1G30.44189937
101CSNK1A10.43673272
102MAP3K70.42539781
103FYN0.41873162
104CSNK1D0.41512323
105PTK2B0.41176745
106PRKAA10.41067989
107AURKA0.40862187
108CSNK1E0.39489844
109ADRBK10.38667037
110CAMK2D0.38352414
111ROCK20.38072379
112PRKCZ0.37539122
113PRKDC0.36409004
114MAPK90.35031340
115PRKACA0.34295062
116CDK30.34050682
117FGFR20.33470059
118EPHB20.33266670
119PDGFRA0.32410103
120MAP3K10.32395042
121PRKACB0.31489782
122PIM20.31428557
123PRKCE0.31172926
124PRKCB0.31031267
125PDK10.31003570
126DYRK30.30171133
127FER0.30163310
128GSK3B0.29953991
129MAPK150.29670043
130RPS6KA40.28869360
131OXSR10.28756790
132RPS6KB10.28171963
133MAPK80.28040168
134PLK30.27822900
135ICK0.27275883
136MAPKAPK50.26791905
137RPS6KA50.24311630

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.79904034
2Synaptic vesicle cycle_Homo sapiens_hsa047213.33937283
3GABAergic synapse_Homo sapiens_hsa047272.83087799
4Circadian entrainment_Homo sapiens_hsa047132.68418333
5Olfactory transduction_Homo sapiens_hsa047402.66763223
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58506511
7Long-term potentiation_Homo sapiens_hsa047202.57553351
8Morphine addiction_Homo sapiens_hsa050322.54367687
9Amphetamine addiction_Homo sapiens_hsa050312.45739166
10Glutamatergic synapse_Homo sapiens_hsa047242.45441114
11Dopaminergic synapse_Homo sapiens_hsa047282.22464923
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16749948
13Salivary secretion_Homo sapiens_hsa049701.95177906
14Cocaine addiction_Homo sapiens_hsa050301.92147461
15Insulin secretion_Homo sapiens_hsa049111.91455542
16Cholinergic synapse_Homo sapiens_hsa047251.85189241
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77506141
18Gastric acid secretion_Homo sapiens_hsa049711.75235040
19Long-term depression_Homo sapiens_hsa047301.73144173
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67514659
21Serotonergic synapse_Homo sapiens_hsa047261.65191303
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62887903
23Renin secretion_Homo sapiens_hsa049241.62722368
24Taste transduction_Homo sapiens_hsa047421.60498141
25Oxytocin signaling pathway_Homo sapiens_hsa049211.59919598
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53316804
27Calcium signaling pathway_Homo sapiens_hsa040201.52951674
28Gap junction_Homo sapiens_hsa045401.42013887
29GnRH signaling pathway_Homo sapiens_hsa049121.41876749
30Collecting duct acid secretion_Homo sapiens_hsa049661.30274331
31Steroid biosynthesis_Homo sapiens_hsa001001.25035568
32cAMP signaling pathway_Homo sapiens_hsa040241.24868697
33Oxidative phosphorylation_Homo sapiens_hsa001901.24102281
34Parkinsons disease_Homo sapiens_hsa050121.23458183
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22851813
36Estrogen signaling pathway_Homo sapiens_hsa049151.22083089
37Axon guidance_Homo sapiens_hsa043601.21630132
38Oocyte meiosis_Homo sapiens_hsa041141.20464738
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20409917
40Melanogenesis_Homo sapiens_hsa049161.18685049
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18304800
42Glioma_Homo sapiens_hsa052141.17396367
43ErbB signaling pathway_Homo sapiens_hsa040121.12391711
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12132198
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07759240
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07214119
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07204410
48Type II diabetes mellitus_Homo sapiens_hsa049301.06350512
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05831725
50Fatty acid elongation_Homo sapiens_hsa000621.04276293
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04073393
52Butanoate metabolism_Homo sapiens_hsa006501.03542930
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03158911
54Vibrio cholerae infection_Homo sapiens_hsa051100.98607870
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94617048
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93250738
57Alcoholism_Homo sapiens_hsa050340.91811572
58Biosynthesis of amino acids_Homo sapiens_hsa012300.87496746
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.87105003
60Alzheimers disease_Homo sapiens_hsa050100.86368286
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.84285703
62Vitamin B6 metabolism_Homo sapiens_hsa007500.83415379
63MAPK signaling pathway_Homo sapiens_hsa040100.82983318
64Regulation of autophagy_Homo sapiens_hsa041400.82828566
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81102597
66Dorso-ventral axis formation_Homo sapiens_hsa043200.80840600
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80157387
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.79545817
69Huntingtons disease_Homo sapiens_hsa050160.79399293
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79348472
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78528848
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77759870
73Cardiac muscle contraction_Homo sapiens_hsa042600.73371047
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73348967
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73209410
76Thyroid hormone synthesis_Homo sapiens_hsa049180.70781549
77Dilated cardiomyopathy_Homo sapiens_hsa054140.70377289
78Phototransduction_Homo sapiens_hsa047440.69901120
79Type I diabetes mellitus_Homo sapiens_hsa049400.69733428
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69569001
81Choline metabolism in cancer_Homo sapiens_hsa052310.68990763
82Wnt signaling pathway_Homo sapiens_hsa043100.68196107
83Endometrial cancer_Homo sapiens_hsa052130.68176524
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66027365
85Colorectal cancer_Homo sapiens_hsa052100.64635527
86Non-small cell lung cancer_Homo sapiens_hsa052230.62224010
87mTOR signaling pathway_Homo sapiens_hsa041500.62082508
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61591089
89Protein export_Homo sapiens_hsa030600.60362930
90Ras signaling pathway_Homo sapiens_hsa040140.59363194
91Arginine and proline metabolism_Homo sapiens_hsa003300.58790897
92Pancreatic secretion_Homo sapiens_hsa049720.58366635
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57804048
94VEGF signaling pathway_Homo sapiens_hsa043700.57762178
95Rap1 signaling pathway_Homo sapiens_hsa040150.57693665
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57013069
97Inositol phosphate metabolism_Homo sapiens_hsa005620.56692564
98beta-Alanine metabolism_Homo sapiens_hsa004100.56564914
99Base excision repair_Homo sapiens_hsa034100.55669470
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55650257
101Circadian rhythm_Homo sapiens_hsa047100.54672842
102Glucagon signaling pathway_Homo sapiens_hsa049220.54472980
103AMPK signaling pathway_Homo sapiens_hsa041520.52861103
104Sulfur relay system_Homo sapiens_hsa041220.52662647
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51770324
106Hedgehog signaling pathway_Homo sapiens_hsa043400.51167071
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.50258902
108Fatty acid metabolism_Homo sapiens_hsa012120.48964528
109Endocytosis_Homo sapiens_hsa041440.48699517
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48366051
111Renal cell carcinoma_Homo sapiens_hsa052110.47813738
112Carbon metabolism_Homo sapiens_hsa012000.47064012
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46988130
114Insulin signaling pathway_Homo sapiens_hsa049100.45240738
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43370089
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40960158
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39887507
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39806856
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38521403
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37634573
121Propanoate metabolism_Homo sapiens_hsa006400.37027624
122Spliceosome_Homo sapiens_hsa030400.36770351
123Hippo signaling pathway_Homo sapiens_hsa043900.36426047
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35895712
125Chemokine signaling pathway_Homo sapiens_hsa040620.34148965
126Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33842166
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33097403
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.32849579
129mRNA surveillance pathway_Homo sapiens_hsa030150.30945773
130Basal cell carcinoma_Homo sapiens_hsa052170.30718507
131Tight junction_Homo sapiens_hsa045300.29943562
132Ovarian steroidogenesis_Homo sapiens_hsa049130.29578396
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29252086
134Thyroid cancer_Homo sapiens_hsa052160.27070648

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