USP12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)4.61852846
2negative regulation of interleukin-12 production (GO:0032695)4.24753515
3response to peptidoglycan (GO:0032494)4.18439477
4regulation of vitamin metabolic process (GO:0030656)3.77095096
5cellular response to thyroid hormone stimulus (GO:0097067)3.53419435
6positive regulation by symbiont of host defense response (GO:0052509)3.51999513
7modulation by symbiont of host defense response (GO:0052031)3.51999513
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.51999513
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.51999513
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.51999513
11modulation by symbiont of host immune response (GO:0052553)3.51999513
12regulation of podosome assembly (GO:0071801)3.51854856
13regulation of interferon-beta biosynthetic process (GO:0045357)3.51212784
14germinal center formation (GO:0002467)3.44846144
15regulation of T-helper 1 cell differentiation (GO:0045625)3.39973283
16positive regulation of heat generation (GO:0031652)3.35426947
17regulation of fever generation (GO:0031620)3.32330296
18positive regulation of interferon-alpha production (GO:0032727)3.31130751
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30417649
20negative regulation of erythrocyte differentiation (GO:0045647)3.30357255
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.28379934
22regulation of clathrin-mediated endocytosis (GO:2000369)3.21365299
23regulation of cytokine secretion involved in immune response (GO:0002739)3.20754645
24T-helper 1 type immune response (GO:0042088)3.19940331
25positive regulation of chemokine biosynthetic process (GO:0045080)3.19725697
26NIK/NF-kappaB signaling (GO:0038061)3.19681493
27negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.19471128
28negative regulation of cell killing (GO:0031342)3.15647782
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.15647782
30macrophage activation involved in immune response (GO:0002281)3.15445057
31protein localization to endosome (GO:0036010)3.13425888
32neutrophil activation involved in immune response (GO:0002283)3.11898829
33regulation of interferon-alpha production (GO:0032647)3.11809850
34low-density lipoprotein particle clearance (GO:0034383)3.08427608
35sodium ion export (GO:0071436)3.05178704
36response to muramyl dipeptide (GO:0032495)3.05106014
37myeloid dendritic cell differentiation (GO:0043011)3.03776991
38macroautophagy (GO:0016236)2.95808123
39regulation of NFAT protein import into nucleus (GO:0051532)2.95659344
40response to protozoan (GO:0001562)2.93751004
41glycosphingolipid catabolic process (GO:0046479)2.93644915
42detection of molecule of bacterial origin (GO:0032490)2.92648384
43regulation of cholesterol storage (GO:0010885)2.89196665
44oligosaccharide catabolic process (GO:0009313)2.88819600
45regulation of T-helper 2 cell differentiation (GO:0045628)2.86939795
46positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.85236373
47regulation of chronic inflammatory response (GO:0002676)2.84226039
48defense response to protozoan (GO:0042832)2.83712266
49regulation of necroptotic process (GO:0060544)2.83106430
50antigen processing and presentation of endogenous antigen (GO:0019883)2.80990014
51antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.80433220
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.80433220
53regulation of mononuclear cell migration (GO:0071675)2.79359958
54NLS-bearing protein import into nucleus (GO:0006607)2.79308010
55regulation of chemokine biosynthetic process (GO:0045073)2.79288933
56growth hormone receptor signaling pathway (GO:0060396)2.77532275
57regulation of interleukin-12 biosynthetic process (GO:0045075)2.77335587
58regulation of ARF protein signal transduction (GO:0032012)2.77018693
59negative regulation of lipid storage (GO:0010888)2.75028852
60cell adhesion mediated by integrin (GO:0033627)2.73720796
61myeloid dendritic cell activation (GO:0001773)2.70733785
62positive regulation of histone deacetylation (GO:0031065)2.70562483
63I-kappaB phosphorylation (GO:0007252)2.69198124
64cellular response to ethanol (GO:0071361)2.68074908
65response to thyroid hormone (GO:0097066)2.68009442
66dicarboxylic acid biosynthetic process (GO:0043650)2.67620449
67cytoplasmic mRNA processing body assembly (GO:0033962)2.66920239
68cellular response to lipopolysaccharide (GO:0071222)2.65634483
69regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.64930796
70regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.64353300
71glycolipid catabolic process (GO:0019377)2.63537376
72cellular response to arsenic-containing substance (GO:0071243)2.63257750
73positive regulation of type 2 immune response (GO:0002830)2.62371590
74positive regulation of nitric oxide biosynthetic process (GO:0045429)2.61132775
75positive regulation of p38MAPK cascade (GO:1900745)2.60684792
76negative regulation of cytokine production involved in immune response (GO:0002719)2.60548091
77regulation of cholesterol homeostasis (GO:2000188)2.60197229
78cellular response to molecule of bacterial origin (GO:0071219)2.59008039
79positive regulation of NF-kappaB import into nucleus (GO:0042346)2.58102906
80granulocyte activation (GO:0036230)2.57946367
81positive regulation of cellular amide metabolic process (GO:0034250)2.57611134
82synaptic vesicle maturation (GO:0016188)2.57163685
83modulation by symbiont of host cellular process (GO:0044068)2.56850807
84positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.56004591
85positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.55892650
86lipoprotein transport (GO:0042953)2.55053073
87regulation of response to interferon-gamma (GO:0060330)2.54705457
88macrophage activation (GO:0042116)2.54362620
89apoptotic cell clearance (GO:0043277)2.53469348
90monocyte chemotaxis (GO:0002548)2.53193057
91regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.51645198
92regulation of NF-kappaB import into nucleus (GO:0042345)2.51595985
93positive regulation of interleukin-6 production (GO:0032755)2.50524500
94regulation of nitric oxide biosynthetic process (GO:0045428)2.50432108
95stress fiber assembly (GO:0043149)2.49468472
96cytoskeletal anchoring at plasma membrane (GO:0007016)2.49386988
97regulation of interleukin-12 production (GO:0032655)2.48813477
98positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.48666339
99regulation of type I interferon-mediated signaling pathway (GO:0060338)2.47772943
100cellular extravasation (GO:0045123)2.46905004
101regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.46102978
102JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.45180519
103proline transport (GO:0015824)2.44102577
104ovulation (GO:0030728)2.42751263
105activation of MAPKKK activity (GO:0000185)2.42728769
106cellular potassium ion homeostasis (GO:0030007)2.40683342
107response to host immune response (GO:0052572)2.39717957
108response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.39717957
109positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.39128900
110embryonic process involved in female pregnancy (GO:0060136)2.38255712
111regulation of ARF GTPase activity (GO:0032312)2.37410394
112positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.36722621
113regulation of early endosome to late endosome transport (GO:2000641)2.36697105
114positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.36532316
115response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.36215990
116response to host (GO:0075136)2.36215990
117response to host defenses (GO:0052200)2.36215990
118dendritic cell differentiation (GO:0097028)2.35103102
119response to nerve growth factor (GO:1990089)2.34884277
120cellular response to nerve growth factor stimulus (GO:1990090)2.34884277
121myeloid cell activation involved in immune response (GO:0002275)2.34303477
122negative regulation of interleukin-17 production (GO:0032700)2.34231240
123T cell migration (GO:0072678)2.34108907
124cellular response to biotic stimulus (GO:0071216)2.33486095
125cellular response to growth hormone stimulus (GO:0071378)2.31518715
126regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.31413755
127lipopolysaccharide-mediated signaling pathway (GO:0031663)2.29336217
128positive regulation of gamma-delta T cell activation (GO:0046645)2.27231662
129regulation of membrane protein ectodomain proteolysis (GO:0051043)2.25583949
130positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.25326792
131sexual reproduction (GO:0019953)2.23625198
132nerve growth factor signaling pathway (GO:0038180)2.21890199
133natural killer cell differentiation (GO:0001779)2.21743817
134negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.21024844
135regulation of gamma-delta T cell differentiation (GO:0045586)2.20542113
136negative regulation of cell size (GO:0045792)2.19752845
137locomotory exploration behavior (GO:0035641)2.19536859
138receptor catabolic process (GO:0032801)2.18575194
139positive regulation of interferon-beta production (GO:0032728)2.18521545
140positive regulation of macrophage cytokine production (GO:0060907)2.15789097
141cellular response to interferon-alpha (GO:0035457)2.12122155
142regulation of short-term neuronal synaptic plasticity (GO:0048172)2.11081296
143regulation of p38MAPK cascade (GO:1900744)2.09766457
144response to type I interferon (GO:0034340)2.09604240
145interferon-gamma-mediated signaling pathway (GO:0060333)2.09456536
146cortical actin cytoskeleton organization (GO:0030866)2.09045044
147regulation of gamma-delta T cell activation (GO:0046643)2.08591413
148signal complex assembly (GO:0007172)2.07516374
149negative regulation of lipid transport (GO:0032369)2.07046308
150peptidyl-threonine modification (GO:0018210)2.05941612
151regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.04267670
152cellular response to type I interferon (GO:0071357)2.02733106
153type I interferon signaling pathway (GO:0060337)2.02733106
154clathrin coat assembly (GO:0048268)2.02395315
155regulation of fatty acid beta-oxidation (GO:0031998)2.02381087
156establishment of protein localization to Golgi (GO:0072600)2.02057451
157pre-miRNA processing (GO:0031054)2.01703580
158positive regulation of lipid storage (GO:0010884)2.01140854
159synaptic vesicle docking involved in exocytosis (GO:0016081)2.00782041
160natural killer cell mediated immunity (GO:0002228)2.00655774
161natural killer cell mediated cytotoxicity (GO:0042267)2.00655774
162peptidyl-lysine dimethylation (GO:0018027)2.00314544
163endocytic recycling (GO:0032456)1.99570814
164phospholipid homeostasis (GO:0055091)1.99320887
165plasma membrane repair (GO:0001778)1.98826279
166cell communication by electrical coupling involved in cardiac conduction (GO:0086064)1.97352253
167regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00431.96447879
168peptidyl-threonine phosphorylation (GO:0018107)1.96421227
169positive regulation of lipid catabolic process (GO:0050996)1.95856630
170alanine transport (GO:0032328)1.95702291
171immunoglobulin mediated immune response (GO:0016064)1.95516021

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.87018933
2GATA1_22025678_ChIP-Seq_K562_Human3.08226503
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.05010464
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.98329384
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.67418923
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.58590721
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.33843423
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.31099478
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23906347
10SCL_19346495_ChIP-Seq_HPC-7_Human2.20913185
11* IRF8_27001747_Chip-Seq_BMDM_Mouse2.11167214
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.09126007
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08763403
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.03077728
15KDM2B_26808549_Chip-Seq_DND41_Human2.02401997
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00604253
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98163229
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97065793
19TCF7_22412390_ChIP-Seq_EML_Mouse1.90892089
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87357117
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.79728618
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.78792814
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74874652
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.72891982
25KDM2B_26808549_Chip-Seq_K562_Human1.71755732
26* LXR_22158963_ChIP-Seq_LIVER_Mouse1.70025076
27* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68339337
28RXR_22158963_ChIP-Seq_LIVER_Mouse1.67091122
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.63876924
30MYC_22102868_ChIP-Seq_BL_Human1.61011089
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56750730
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55830557
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55439453
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50841599
35MYB_26560356_Chip-Seq_TH2_Human1.49993746
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47520301
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47181011
38P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45411756
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.44728958
40LXR_22292898_ChIP-Seq_THP-1_Human1.44068690
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44045163
42CLOCK_20551151_ChIP-Seq_293T_Human1.43778219
43SPI1_23127762_ChIP-Seq_K562_Human1.42435261
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.40460393
45* SPI1_23547873_ChIP-Seq_NB4_Human1.40405388
46KDM2B_26808549_Chip-Seq_JURKAT_Human1.39214162
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.37504714
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37313801
49ZNF263_19887448_ChIP-Seq_K562_Human1.37230072
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36945811
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36798102
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36151692
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.35086247
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33711120
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32552221
56SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31102697
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28520200
58MYB_26560356_Chip-Seq_TH1_Human1.27241879
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25601242
60* MAF_26560356_Chip-Seq_TH1_Human1.25199037
61* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24303151
62FOXA2_19822575_ChIP-Seq_HepG2_Human1.23480253
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22632199
64RUNX_20019798_ChIP-Seq_JUKART_Human1.21588586
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21333071
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21333071
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20428519
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20081519
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19702921
70* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19697891
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19689996
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19112392
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18108128
74* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17955338
75ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17465048
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16252741
77FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15659844
78RACK7_27058665_Chip-Seq_MCF-7_Human1.14867665
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14323172
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13156885
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13119704
82* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13026544
83DROSHA_22980978_ChIP-Seq_HELA_Human1.12022077
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11842995
85MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11324022
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10796627
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10668904
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10668904
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10668904
90GATA2_21666600_ChIP-Seq_HMVEC_Human1.09953626
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08599235
92TFEB_21752829_ChIP-Seq_HELA_Human1.07830208
93VDR_24787735_ChIP-Seq_THP-1_Human1.07688056
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07667202
95GATA1_19941827_ChIP-Seq_MEL86_Mouse1.06225740
96TP63_17297297_ChIP-ChIP_HaCaT_Human1.05728652
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05609532
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04328749
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04144474
100VDR_21846776_ChIP-Seq_THP-1_Human1.04083010
101GATA1_19941826_ChIP-Seq_K562_Human1.03627060
102* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03346470
103EGR1_19032775_ChIP-ChIP_M12_Human1.02695043
104ATF3_27146783_Chip-Seq_COLON_Human1.02619098
105RARB_27405468_Chip-Seq_BRAIN_Mouse1.02166310
106* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02093670
107CREB1_26743006_Chip-Seq_LNCaP_Human1.02007835
108PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00889209
109RUNX1_27514584_Chip-Seq_MCF-7_Human1.00793658
110VDR_24763502_ChIP-Seq_THP-1_Human1.00675737
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00282408
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99882743
113GATA6_25053715_ChIP-Seq_YYC3_Human0.99513634
114UTX_26944678_Chip-Seq_JUKART_Human0.98635725
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98531812
116PU_27001747_Chip-Seq_BMDM_Mouse0.97219242
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95702510
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95415984
119GATA1_19941827_ChIP-Seq_MEL_Mouse0.95221686
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94864975
121IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94694182
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94465432
123RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94422612
124FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94309897
125* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93786499
126SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93756567
127* GATA2_19941826_ChIP-Seq_K562_Human0.92015248
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91552394
129MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90797372
130* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90141607
131GATA3_27048872_Chip-Seq_THYMUS_Human0.90140216
132NCOR1_26117541_ChIP-Seq_K562_Human0.89427466
133PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88325052
134CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87900355
135* CDX2_20551321_ChIP-Seq_CACO-2_Human0.87277249
136TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86922506
137* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86485924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.78443816
2MP0003705_abnormal_hypodermis_morpholog3.52210774
3MP0003656_abnormal_erythrocyte_physiolo3.15188807
4MP0000569_abnormal_digit_pigmentation3.10268870
5MP0004510_myositis3.06987807
6MP0003300_gastrointestinal_ulcer3.04257544
7MP0010234_abnormal_vibrissa_follicle2.91558150
8MP0005451_abnormal_body_composition2.85058865
9MP0005360_urolithiasis2.57444134
10MP0010352_gastrointestinal_tract_polyps2.49562040
11MP0003724_increased_susceptibility_to2.39766133
12MP0005076_abnormal_cell_differentiation2.36119937
13MP0004859_abnormal_synaptic_plasticity2.34536736
14MP0004858_abnormal_nervous_system2.25981406
15MP0009840_abnormal_foam_cell2.22799397
16MP0003252_abnormal_bile_duct2.05458738
17MP0008961_abnormal_basal_metabolism2.04456188
18MP0005167_abnormal_blood-brain_barrier2.02008124
19MP0003436_decreased_susceptibility_to2.00896952
20MP0003075_altered_response_to1.93223381
21MP0002138_abnormal_hepatobiliary_system1.91756019
22MP0008260_abnormal_autophagy1.91414456
23MP0008004_abnormal_stomach_pH1.85492506
24MP0006082_CNS_inflammation1.84611124
25MP0001835_abnormal_antigen_presentation1.83898620
26MP0004947_skin_inflammation1.80330054
27MP0005058_abnormal_lysosome_morphology1.77688514
28MP0003191_abnormal_cellular_cholesterol1.71425776
29MP0002139_abnormal_hepatobiliary_system1.71160495
30MP0002877_abnormal_melanocyte_morpholog1.66553028
31MP0003045_fibrosis1.64708195
32MP0002332_abnormal_exercise_endurance1.61313008
33MP0003172_abnormal_lysosome_physiology1.60969260
34MP0000604_amyloidosis1.60624830
35MP0003566_abnormal_cell_adhesion1.59928350
36MP0005397_hematopoietic_system_phenotyp1.57226297
37MP0001545_abnormal_hematopoietic_system1.57226297
38MP0001853_heart_inflammation1.55233436
39MP0000343_altered_response_to1.53665907
40MP0005387_immune_system_phenotype1.53623398
41MP0001790_abnormal_immune_system1.53623398
42MP0000858_altered_metastatic_potential1.48002740
43MP0005166_decreased_susceptibility_to1.46428044
44MP0003091_abnormal_cell_migration1.45989396
45MP0004130_abnormal_muscle_cell1.45901425
46MP0000685_abnormal_immune_system1.44316357
47MP0010307_abnormal_tumor_latency1.40283495
48MP0002254_reproductive_system_inflammat1.39630530
49MP0004185_abnormal_adipocyte_glucose1.38695798
50MP0004808_abnormal_hematopoietic_stem1.38691242
51MP0005000_abnormal_immune_tolerance1.36202372
52MP0009278_abnormal_bone_marrow1.35840859
53MP0009780_abnormal_chondrocyte_physiolo1.34004842
54MP0003828_pulmonary_edema1.33184250
55MP0010329_abnormal_lipoprotein_level1.30837753
56MP0002398_abnormal_bone_marrow1.24845282
57MP0005085_abnormal_gallbladder_physiolo1.24842445
58MP0002419_abnormal_innate_immunity1.24784655
59MP0002998_abnormal_bone_remodeling1.24544643
60MP0003763_abnormal_thymus_physiology1.24341540
61MP0003183_abnormal_peptide_metabolism1.23666143
62MP0005464_abnormal_platelet_physiology1.23565127
63MP0002909_abnormal_adrenal_gland1.23450713
64MP0002452_abnormal_antigen_presenting1.22384686
65MP0001800_abnormal_humoral_immune1.20274302
66MP0006054_spinal_hemorrhage1.20046254
67MP0009333_abnormal_splenocyte_physiolog1.19198484
68MP0000609_abnormal_liver_physiology1.15686972
69MP0010155_abnormal_intestine_physiology1.13431030
70MP0001533_abnormal_skeleton_physiology1.10808624
71MP0002723_abnormal_immune_serum1.09607690
72MP0002166_altered_tumor_susceptibility1.07828076
73MP0005025_abnormal_response_to1.06738563
74MP0005164_abnormal_response_to1.05910101
75MP0005365_abnormal_bile_salt1.05733629
76MP0001845_abnormal_inflammatory_respons1.05582124
77MP0009785_altered_susceptibility_to1.04902368
78MP0005310_abnormal_salivary_gland1.04886523
79MP0001849_ear_inflammation1.00909990
80MP0001666_abnormal_nutrient_absorption1.00169977
81MP0002006_tumorigenesis0.99381236
82MP0002429_abnormal_blood_cell0.98769364
83MP0001851_eye_inflammation0.98016536
84MP0002090_abnormal_vision0.97595276
85MP0005623_abnormal_meninges_morphology0.97174223
86MP0000689_abnormal_spleen_morphology0.96788771
87MP0008057_abnormal_DNA_replication0.95833750
88MP0009764_decreased_sensitivity_to0.95277955
89MP0002722_abnormal_immune_system0.94702370
90MP0003221_abnormal_cardiomyocyte_apopto0.94528164
91MP0001819_abnormal_immune_cell0.92858517
92MP0005666_abnormal_adipose_tissue0.92497466
93MP0008469_abnormal_protein_level0.91597436
94MP0002420_abnormal_adaptive_immunity0.88311176
95MP0009763_increased_sensitivity_to0.87277973
96MP0004019_abnormal_vitamin_homeostasis0.86129098
97MP0003453_abnormal_keratinocyte_physiol0.86095970
98MP0003448_altered_tumor_morphology0.85723276
99MP0003866_abnormal_defecation0.84340000
100MP0009765_abnormal_xenobiotic_induced0.83320296
101MP0002136_abnormal_kidney_physiology0.83152779
102MP0005375_adipose_tissue_phenotype0.80317771
103MP0003283_abnormal_digestive_organ0.80291979
104MP0003329_amyloid_beta_deposits0.79830590
105MP0003950_abnormal_plasma_membrane0.79520395
106MP0003690_abnormal_glial_cell0.79171238
107MP0001501_abnormal_sleep_pattern0.78876062
108MP0005319_abnormal_enzyme/_coenzyme0.78128840
109MP0000465_gastrointestinal_hemorrhage0.77619275
110MP0002148_abnormal_hypersensitivity_rea0.75784643
111MP0005621_abnormal_cell_physiology0.75646246
112MP0000733_abnormal_muscle_development0.75575934
113MP0000249_abnormal_blood_vessel0.75144327
114MP0004883_abnormal_blood_vessel0.75022912
115MP0000920_abnormal_myelination0.74257069
116MP0002928_abnormal_bile_duct0.74031573
117MP0008875_abnormal_xenobiotic_pharmacok0.73795239
118MP0001348_abnormal_lacrimal_gland0.73671443
119MP0005671_abnormal_response_to0.73305101
120MP0002118_abnormal_lipid_homeostasis0.73211918
121MP0008874_decreased_physiological_sensi0.71545302
122MP0005165_increased_susceptibility_to0.69752414
123MP0005535_abnormal_body_temperature0.69725901
124MP0003633_abnormal_nervous_system0.67935385
125MP0009643_abnormal_urine_homeostasis0.67820524
126MP0005023_abnormal_wound_healing0.66815550
127MP0000371_diluted_coat_color0.66122716
128MP0002405_respiratory_system_inflammati0.66091820
129MP0002896_abnormal_bone_mineralization0.65816989
130MP0002971_abnormal_brown_adipose0.65803241
131MP0000716_abnormal_immune_system0.65356252
132MP0005670_abnormal_white_adipose0.64793805
133MP0002168_other_aberrant_phenotype0.64413655
134MP0001765_abnormal_ion_homeostasis0.64179005
135MP0001915_intracranial_hemorrhage0.63453602
136MP0005409_darkened_coat_color0.61853914

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)3.07578361
2Optic neuritis (HP:0100653)3.03593364
3Retrobulbar optic neuritis (HP:0100654)3.03593364
4Neurofibrillary tangles (HP:0002185)3.02105125
5Loss of speech (HP:0002371)3.01768415
6Cerebral aneurysm (HP:0004944)2.98957659
7Pigmentary retinal degeneration (HP:0001146)2.92270463
8Autoimmune thrombocytopenia (HP:0001973)2.89481384
9Hematochezia (HP:0002573)2.87971902
10Mediastinal lymphadenopathy (HP:0100721)2.81620756
11T lymphocytopenia (HP:0005403)2.79886440
12Abnormality of the vasculature of the conjunctiva (HP:0008054)2.77726847
13Myocardial infarction (HP:0001658)2.64012070
14Eczematoid dermatitis (HP:0000976)2.63847543
15Interstitial pulmonary disease (HP:0006530)2.60891472
16Slow saccadic eye movements (HP:0000514)2.59918689
17Frequent falls (HP:0002359)2.54821085
18Systemic lupus erythematosus (HP:0002725)2.51392343
19Hand muscle atrophy (HP:0009130)2.50374265
20Increased neuronal autofluorescent lipopigment (HP:0002074)2.49790767
21Abnormality of T cell number (HP:0011839)2.47945055
22Recurrent gram-negative bacterial infections (HP:0005420)2.45839297
23Upper limb amyotrophy (HP:0009129)2.45695807
24Distal upper limb amyotrophy (HP:0007149)2.45695807
25Myositis (HP:0100614)2.45469878
26Spontaneous hematomas (HP:0007420)2.40481867
27Keratoconjunctivitis sicca (HP:0001097)2.38611059
28Autoimmune hemolytic anemia (HP:0001890)2.34181264
29Polycythemia (HP:0001901)2.31645039
30Disinhibition (HP:0000734)2.29909520
31Abnormality of the lower motor neuron (HP:0002366)2.28899005
32Increased cerebral lipofuscin (HP:0011813)2.28339219
33Stomatitis (HP:0010280)2.27806296
34Conjunctival telangiectasia (HP:0000524)2.27460681
35Macroorchidism (HP:0000053)2.24566306
36Thoracolumbar scoliosis (HP:0002944)2.22042244
37Hyperacusis (HP:0010780)2.21705829
38Gastrointestinal infarctions (HP:0005244)2.20837302
39Nuclear cataract (HP:0100018)2.20505586
40Supranuclear gaze palsy (HP:0000605)2.20421929
41Gingival bleeding (HP:0000225)2.20294639
42Abnormality of the Achilles tendon (HP:0005109)2.17881062
43Neuronal loss in central nervous system (HP:0002529)2.17740079
44Achilles tendon contracture (HP:0001771)2.16135693
45Subacute progressive viral hepatitis (HP:0006572)2.15923234
46Striae distensae (HP:0001065)2.15393080
47Mutism (HP:0002300)2.14188174
48Upper motor neuron abnormality (HP:0002127)2.11636381
49Increased serum ferritin (HP:0003281)2.11404700
50Purpura (HP:0000979)2.10660668
51Esophageal varix (HP:0002040)2.09202763
52Deep venous thrombosis (HP:0002625)2.08606222
53Recurrent bacterial skin infections (HP:0005406)2.08072661
54Aneurysm (HP:0002617)2.07604082
55Pulmonary infiltrates (HP:0002113)2.07430742
56Recurrent skin infections (HP:0001581)2.05425449
57Thin bony cortex (HP:0002753)2.04394433
58Epistaxis (HP:0000421)2.04120554
59Keratoconjunctivitis (HP:0001096)2.03631565
60Increased CSF protein (HP:0002922)2.01768060
61Prolonged bleeding time (HP:0003010)2.01304051
62Arterial thrombosis (HP:0004420)1.99832992
63Nephritis (HP:0000123)1.99393752
64Abnormality of glutamine family amino acid metabolism (HP:0010902)1.98140785
65Mitral valve prolapse (HP:0001634)1.96360031
66Apathy (HP:0000741)1.95380121
67Retinal atrophy (HP:0001105)1.93087659
68Gastrointestinal stroma tumor (HP:0100723)1.92158037
69Global brain atrophy (HP:0002283)1.91778833
70Poikilocytosis (HP:0004447)1.91332567
71IgA deficiency (HP:0002720)1.91064120
72Enlarged penis (HP:0000040)1.90781723
73Glomerulonephritis (HP:0000099)1.90164754
74Colitis (HP:0002583)1.89596810
75Complement deficiency (HP:0004431)1.88162681
76Aortic aneurysm (HP:0004942)1.87556746
77Gangrene (HP:0100758)1.86450968
78Urinary glycosaminoglycan excretion (HP:0003541)1.85836667
79Mucopolysacchariduria (HP:0008155)1.85836667
80Petechiae (HP:0000967)1.85523303
81Lymphangioma (HP:0100764)1.83839202
82Polygenic inheritance (HP:0010982)1.82134898
83Amyloidosis (HP:0011034)1.81505866
84Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80041978
85Bone pain (HP:0002653)1.80010011
86Abnormality of the lumbar spine (HP:0100712)1.79632255
87Heterotopia (HP:0002282)1.79284107
88Recurrent abscess formation (HP:0002722)1.79128701
89Osteomyelitis (HP:0002754)1.78939506
90Axonal loss (HP:0003447)1.78804863
91Congenital stationary night blindness (HP:0007642)1.78750262
92Diminished motivation (HP:0000745)1.77300424
93Dysostosis multiplex (HP:0000943)1.77000230
94Cortical dysplasia (HP:0002539)1.76371295
95Progressive visual loss (HP:0000529)1.76239340
96Abnormality of polysaccharide metabolism (HP:0011012)1.76119432
97Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76119432
98Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76119432
99Dysmetric saccades (HP:0000641)1.75971160
100Meningitis (HP:0001287)1.75917595
101Basal ganglia calcification (HP:0002135)1.75801852
102Abnormality of the nasal mucosa (HP:0000433)1.75560178
103Xanthomatosis (HP:0000991)1.75413518
104Resting tremor (HP:0002322)1.75341881
105Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75147231
106Fatigue (HP:0012378)1.74883460
107Thoracic kyphosis (HP:0002942)1.74776904
108Dilatation of the ascending aorta (HP:0005111)1.74322285
109Amaurosis fugax (HP:0100576)1.73986343
110Focal segmental glomerulosclerosis (HP:0000097)1.72811697
111Nasal polyposis (HP:0100582)1.72634912
112Pathologic fracture (HP:0002756)1.72149697
113Peritonitis (HP:0002586)1.72142666
114Abnormality of iron homeostasis (HP:0011031)1.72099483
115Personality changes (HP:0000751)1.71539782
116Inappropriate behavior (HP:0000719)1.71459908
117Abnormality of proline metabolism (HP:0010907)1.71316570
118Hydroxyprolinuria (HP:0003080)1.71316570
119Increased mean platelet volume (HP:0011877)1.70070445
120Tetraparesis (HP:0002273)1.69462373
121Urethral obstruction (HP:0000796)1.69345968
122Bundle branch block (HP:0011710)1.69024610
123Abnormal platelet volume (HP:0011876)1.68665899
124Difficulty climbing stairs (HP:0003551)1.68163295
125Elfin facies (HP:0004428)1.67912755
126Orthostatic hypotension (HP:0001278)1.67599943
127Increased density of long bones (HP:0006392)1.67539882
128Gingivitis (HP:0000230)1.67338986
129Glomerulopathy (HP:0100820)1.67195301
130Recurrent fungal infections (HP:0002841)1.67140615
131Viral hepatitis (HP:0006562)1.65541821
132Urticaria (HP:0001025)1.65310651
133Agnosia (HP:0010524)1.65303589
134Abnormality of the periventricular white matter (HP:0002518)1.64986616
135Papilledema (HP:0001085)1.64791583
136Postural instability (HP:0002172)1.64266154
137Orchitis (HP:0100796)1.64095617
138Action tremor (HP:0002345)1.63858647
139Recurrent viral infections (HP:0004429)1.62204703
140Abnormality of complement system (HP:0005339)1.61877350
141Epidermoid cyst (HP:0200040)1.61469260
142Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.61414805
143Asymmetric septal hypertrophy (HP:0001670)1.60925340
144Abnormality of macrophages (HP:0004311)1.57403224
145Vasculitis (HP:0002633)1.57058040
146Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.57032843
147Hemorrhage of the eye (HP:0011885)1.56330804
148Long toe (HP:0010511)1.55636613
149Cellulitis (HP:0100658)1.55089753
150Cerebral inclusion bodies (HP:0100314)1.54878318
151Bony spicule pigmentary retinopathy (HP:0007737)1.54322501
152Abnormality of glycolipid metabolism (HP:0010969)1.53467848
153Abnormality of liposaccharide metabolism (HP:0010968)1.53467848
154Abnormality of glycosphingolipid metabolism (HP:0004343)1.53467848
155Mitral stenosis (HP:0001718)1.53158760
156Osteolytic defects of the phalanges of the hand (HP:0009771)1.52088501
157Osteolytic defects of the hand bones (HP:0009699)1.52088501

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.90020578
2PRPF4B3.87673814
3TRIB33.53145410
4TAOK22.91554779
5PKN22.77623584
6MAP3K92.65072009
7RIPK42.59556354
8RIPK12.58588032
9MAP3K102.40277790
10KSR22.29546270
11ERN12.21116803
12NME22.01299149
13BMPR21.95994445
14MAP3K31.89261999
15TBK11.88323766
16JAK11.88191559
17CAMK1D1.83478889
18CAMK1G1.82832010
19EEF2K1.81262792
20TYK21.78814654
21CDK121.76578666
22IRAK41.75712614
23PTK61.73273745
24GRK71.73226761
25TAOK11.73109226
26CAMKK11.71524984
27SIK21.62921428
28ACVR1B1.62578612
29BLK1.61804865
30MAP3K21.51421969
31ALK1.49473042
32BMX1.49373421
33MAP3K141.49036701
34SCYL21.48880403
35PDGFRA1.46311606
36MAP3K111.45266743
37MAP3K131.39065909
38PRKD31.37034704
39MAP4K11.36351794
40RET1.35903834
41MOS1.35208537
42FGFR41.32806917
43STK241.28161549
44TGFBR21.21685923
45CDC42BPA1.20353492
46FGFR31.19748451
47IRAK21.18917868
48TTN1.17662238
49TESK11.12230332
50DAPK21.10820516
51JAK21.06654241
52IRAK11.06411815
53PDK11.05234759
54JAK31.03864433
55FRK1.02736459
56PAK61.02486757
57PDGFRB0.96863903
58PRKCH0.95185833
59PDPK10.94206650
60LRRK20.93560665
61STK380.91524002
62SIK10.87856708
63NTRK30.86938703
64ICK0.85641003
65MAP3K70.85328598
66LMTK20.84095450
67HCK0.83021810
68GRK60.82613472
69PIM10.80593262
70SGK30.80098446
71CAMKK20.79071253
72PTK20.77355085
73CSK0.76475599
74SGK20.75564015
75EPHB10.74560832
76STK110.74505944
77MAP3K10.73593114
78MAP3K40.72230256
79CDK60.72120071
80MTOR0.71827746
81NTRK10.71598856
82PDK30.71259981
83PDK40.71259981
84MARK30.70544612
85WNK10.69416099
86TRPM70.69265710
87TYRO30.68790271
88TAOK30.68694464
89CLK10.68468536
90EGFR0.67977288
91TXK0.67342026
92IKBKE0.67190178
93ZAP700.66588012
94KSR10.66271468
95MAP2K30.65664397
96STK100.63980663
97CHUK0.62617164
98BTK0.62610100
99MAP2K40.62099135
100LYN0.59234330
101DMPK0.59162480
102YES10.58856762
103LATS10.57901833
104NEK90.57587251
105MAP2K10.56721949
106MINK10.56537544
107MARK20.56337971
108PTK2B0.56018827
109ABL20.55640999
110LATS20.55084975
111MAP3K50.54107728
112STK40.53514864
113DDR20.53031392
114STK30.51807300
115BRD40.50849433
116SIK30.50122478
117FGR0.48424240
118LCK0.48313511
119PRKG20.48217637
120MATK0.48205584
121FGFR10.47106508
122MST1R0.47099672
123IKBKB0.46538824
124HIPK20.45743507
125CDK40.45478293
126PRKCZ0.44866194
127SYK0.44419176
128PIM20.42857331
129MAP3K80.42319922
130MELK0.42253304
131PAK40.40301841
132SGK10.39379534
133RPS6KA40.39243468
134CSF1R0.38898578
135FYN0.38216372
136DYRK1B0.37859915
137TEC0.34812679
138DYRK30.33544755
139MAPK70.31402498
140RPS6KL10.30435950
141RPS6KC10.30435950
142ARAF0.30158224

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.88690561
2Malaria_Homo sapiens_hsa051442.06671174
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.98539583
4Other glycan degradation_Homo sapiens_hsa005111.95778540
5Rheumatoid arthritis_Homo sapiens_hsa053231.69770546
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66475190
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55543410
8Allograft rejection_Homo sapiens_hsa053301.55535621
9Osteoclast differentiation_Homo sapiens_hsa043801.54487863
10Arginine biosynthesis_Homo sapiens_hsa002201.53862765
11Type II diabetes mellitus_Homo sapiens_hsa049301.48232102
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41704827
13Asthma_Homo sapiens_hsa053101.39714283
14Carbohydrate digestion and absorption_Homo sapiens_hsa049731.39235845
15Graft-versus-host disease_Homo sapiens_hsa053321.38691993
16Leishmaniasis_Homo sapiens_hsa051401.37683207
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36905994
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.34676424
19Hematopoietic cell lineage_Homo sapiens_hsa046401.27796377
20B cell receptor signaling pathway_Homo sapiens_hsa046621.25895819
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25535051
22mTOR signaling pathway_Homo sapiens_hsa041501.24561975
23Bladder cancer_Homo sapiens_hsa052191.24442021
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.23096678
25Chronic myeloid leukemia_Homo sapiens_hsa052201.21991931
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21244280
27Phototransduction_Homo sapiens_hsa047441.20906531
28TNF signaling pathway_Homo sapiens_hsa046681.17010188
29Herpes simplex infection_Homo sapiens_hsa051681.15886304
30Staphylococcus aureus infection_Homo sapiens_hsa051501.15825488
31Bile secretion_Homo sapiens_hsa049761.15207360
32Dorso-ventral axis formation_Homo sapiens_hsa043201.14839223
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12927402
34Toxoplasmosis_Homo sapiens_hsa051451.11610348
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.09884525
36Tuberculosis_Homo sapiens_hsa051521.09827189
37Glioma_Homo sapiens_hsa052141.09589769
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.08858087
39VEGF signaling pathway_Homo sapiens_hsa043701.06221373
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05153364
41Type I diabetes mellitus_Homo sapiens_hsa049401.04878450
42Autoimmune thyroid disease_Homo sapiens_hsa053201.04587669
43Insulin resistance_Homo sapiens_hsa049310.99604384
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97905435
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97645033
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96663337
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.94670600
48Synaptic vesicle cycle_Homo sapiens_hsa047210.94055956
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93639995
50Chemokine signaling pathway_Homo sapiens_hsa040620.93320767
51Pertussis_Homo sapiens_hsa051330.92048564
52Influenza A_Homo sapiens_hsa051640.91331519
53Amoebiasis_Homo sapiens_hsa051460.91119729
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90857641
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90119940
56Phagosome_Homo sapiens_hsa041450.89825283
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88299378
58Prolactin signaling pathway_Homo sapiens_hsa049170.88198069
59Long-term potentiation_Homo sapiens_hsa047200.87332957
60Legionellosis_Homo sapiens_hsa051340.86698677
61Salmonella infection_Homo sapiens_hsa051320.86659192
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85767912
63Olfactory transduction_Homo sapiens_hsa047400.85475415
64Pancreatic cancer_Homo sapiens_hsa052120.84966575
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.83812334
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.83383578
67Estrogen signaling pathway_Homo sapiens_hsa049150.83137610
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81988617
69Non-small cell lung cancer_Homo sapiens_hsa052230.80233462
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78863179
71Gastric acid secretion_Homo sapiens_hsa049710.77514744
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.76847249
73Endometrial cancer_Homo sapiens_hsa052130.76226140
74Acute myeloid leukemia_Homo sapiens_hsa052210.76061706
75Antigen processing and presentation_Homo sapiens_hsa046120.75707117
76FoxO signaling pathway_Homo sapiens_hsa040680.73666700
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72896067
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72595548
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72237002
80Mineral absorption_Homo sapiens_hsa049780.72144483
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71362179
82Proteoglycans in cancer_Homo sapiens_hsa052050.71118514
83GnRH signaling pathway_Homo sapiens_hsa049120.70821290
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70682103
85Endocytosis_Homo sapiens_hsa041440.69680687
86Hepatitis B_Homo sapiens_hsa051610.69606963
87Fat digestion and absorption_Homo sapiens_hsa049750.69541279
88Apoptosis_Homo sapiens_hsa042100.68956185
89Hepatitis C_Homo sapiens_hsa051600.68130623
90Renal cell carcinoma_Homo sapiens_hsa052110.67936685
91Renin secretion_Homo sapiens_hsa049240.67471385
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67423127
93Measles_Homo sapiens_hsa051620.66514133
94Cholinergic synapse_Homo sapiens_hsa047250.66479890
95Prostate cancer_Homo sapiens_hsa052150.66339733
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66182617
97Lysosome_Homo sapiens_hsa041420.66115030
98Adherens junction_Homo sapiens_hsa045200.66061434
99Viral myocarditis_Homo sapiens_hsa054160.65605521
100HIF-1 signaling pathway_Homo sapiens_hsa040660.65581049
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.65154919
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.64843465
103African trypanosomiasis_Homo sapiens_hsa051430.63668447
104T cell receptor signaling pathway_Homo sapiens_hsa046600.63653365
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63449360
106Platelet activation_Homo sapiens_hsa046110.63117279
107Insulin signaling pathway_Homo sapiens_hsa049100.62792880
108MicroRNAs in cancer_Homo sapiens_hsa052060.61670182
109Viral carcinogenesis_Homo sapiens_hsa052030.61310171
110Epstein-Barr virus infection_Homo sapiens_hsa051690.60416634
111ErbB signaling pathway_Homo sapiens_hsa040120.60052009
112Shigellosis_Homo sapiens_hsa051310.59888550
113Salivary secretion_Homo sapiens_hsa049700.59111478
114HTLV-I infection_Homo sapiens_hsa051660.58704253
115Prion diseases_Homo sapiens_hsa050200.57722185
116Insulin secretion_Homo sapiens_hsa049110.57402776
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56884295
118Small cell lung cancer_Homo sapiens_hsa052220.56710281
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56198987
120Sphingolipid metabolism_Homo sapiens_hsa006000.55686492
121Lysine degradation_Homo sapiens_hsa003100.54841231
122Oxytocin signaling pathway_Homo sapiens_hsa049210.54092537
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.54090211
124Complement and coagulation cascades_Homo sapiens_hsa046100.53944201
125MAPK signaling pathway_Homo sapiens_hsa040100.53926629
126Inositol phosphate metabolism_Homo sapiens_hsa005620.53804255
127PPAR signaling pathway_Homo sapiens_hsa033200.53691835
128Focal adhesion_Homo sapiens_hsa045100.52766923
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52266279
130Notch signaling pathway_Homo sapiens_hsa043300.49244706
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48077636
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47871237
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45528942
134Primary immunodeficiency_Homo sapiens_hsa053400.44229543
135Choline metabolism in cancer_Homo sapiens_hsa052310.42296102

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