USP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)5.09326729
2protein deneddylation (GO:0000338)4.77876585
3DNA unwinding involved in DNA replication (GO:0006268)4.29359453
4proteasome assembly (GO:0043248)4.24700079
5establishment of integrated proviral latency (GO:0075713)4.21783144
6mitotic chromosome condensation (GO:0007076)4.19192088
7negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.07744149
8purine nucleobase biosynthetic process (GO:0009113)4.05875347
9protein localization to chromosome, centromeric region (GO:0071459)4.02290958
10positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.01116078
11metaphase plate congression (GO:0051310)3.92891115
12regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.91632440
13anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.89628892
14nucleobase biosynthetic process (GO:0046112)3.87462343
15mitotic sister chromatid cohesion (GO:0007064)3.77059020
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.71818543
17regulation of cellular amino acid metabolic process (GO:0006521)3.69101785
18CENP-A containing nucleosome assembly (GO:0034080)3.66528785
19DNA replication checkpoint (GO:0000076)3.65071011
20ribosome biogenesis (GO:0042254)3.63740581
21nuclear pore organization (GO:0006999)3.60939963
22negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.60358573
23negative regulation of ligase activity (GO:0051352)3.60358573
24nuclear pore complex assembly (GO:0051292)3.53913725
25positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.50490990
26chromatin remodeling at centromere (GO:0031055)3.48234841
27kinetochore organization (GO:0051383)3.46138490
28maturation of 5.8S rRNA (GO:0000460)3.44911620
29DNA replication initiation (GO:0006270)3.42837996
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.42022623
31establishment of chromosome localization (GO:0051303)3.40030250
32formation of translation preinitiation complex (GO:0001731)3.38555057
33membrane disassembly (GO:0030397)3.37227895
34nuclear envelope disassembly (GO:0051081)3.37227895
35signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.36610908
36signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.36610908
37signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.36610908
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.36563701
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.36563701
40mitotic metaphase plate congression (GO:0007080)3.33976273
41IMP biosynthetic process (GO:0006188)3.32074588
427-methylguanosine mRNA capping (GO:0006370)3.32040273
43DNA double-strand break processing (GO:0000729)3.29951141
44positive regulation of ligase activity (GO:0051351)3.29265586
45signal transduction involved in DNA integrity checkpoint (GO:0072401)3.28445111
46signal transduction involved in DNA damage checkpoint (GO:0072422)3.28445111
477-methylguanosine RNA capping (GO:0009452)3.27790333
48RNA capping (GO:0036260)3.27790333
49ribosome assembly (GO:0042255)3.27396175
50RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.26733831
51tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.26733831
52DNA strand elongation involved in DNA replication (GO:0006271)3.25883517
53nucleobase-containing small molecule interconversion (GO:0015949)3.24659794
54signal transduction involved in cell cycle checkpoint (GO:0072395)3.24458825
55mitotic sister chromatid segregation (GO:0000070)3.24095504
56G1/S transition of mitotic cell cycle (GO:0000082)3.23457505
57cell cycle G1/S phase transition (GO:0044843)3.23457505
58peptidyl-arginine omega-N-methylation (GO:0035247)3.21837898
59deoxyribonucleotide biosynthetic process (GO:0009263)3.20671656
60spindle checkpoint (GO:0031577)3.18514460
61telomere maintenance via semi-conservative replication (GO:0032201)3.18305677
62establishment of viral latency (GO:0019043)3.18234842
63folic acid-containing compound biosynthetic process (GO:0009396)3.17235016
64negative regulation of chromosome segregation (GO:0051985)3.16843957
65regulation of translational termination (GO:0006449)3.15264965
66mitotic spindle checkpoint (GO:0071174)3.14789788
67negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12267709
68negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.12267709
69negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12267709
70negative regulation of mitotic sister chromatid separation (GO:2000816)3.12267709
71negative regulation of sister chromatid segregation (GO:0033046)3.12267709
72de novo protein folding (GO:0006458)3.11333424
73kinetochore assembly (GO:0051382)3.10297160
74regulation of mitotic spindle organization (GO:0060236)3.09387186
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.08360199
76regulation of mitochondrial translation (GO:0070129)3.07326226
77pseudouridine synthesis (GO:0001522)3.07233799
78histone arginine methylation (GO:0034969)3.07004912
79deoxyribose phosphate biosynthetic process (GO:0046385)3.06765623
802-deoxyribonucleotide biosynthetic process (GO:0009265)3.06765623
81DNA strand elongation (GO:0022616)3.06587745
82regulation of spindle organization (GO:0090224)3.05655531
83regulation of chromosome segregation (GO:0051983)3.05624895
84establishment of protein localization to mitochondrial membrane (GO:0090151)3.05050372
85mitotic spindle assembly checkpoint (GO:0007094)3.03967191
86regulation of helicase activity (GO:0051095)3.03048101
87positive regulation of chromosome segregation (GO:0051984)3.01814232
88spindle assembly checkpoint (GO:0071173)3.01642020
89regulation of ubiquitin-protein transferase activity (GO:0051438)3.01456158
90rRNA modification (GO:0000154)3.01243830
91histone exchange (GO:0043486)3.00814639
92regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99390733
93regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.99390733
94DNA topological change (GO:0006265)2.98483363
95de novo posttranslational protein folding (GO:0051084)2.97488501
96regulation of centriole replication (GO:0046599)2.96257700
97telomere maintenance via recombination (GO:0000722)2.96185872
98L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.95658990
99protein localization to chromosome (GO:0034502)2.93167561
100peptidyl-arginine N-methylation (GO:0035246)2.92630891
101peptidyl-arginine methylation (GO:0018216)2.92630891
102transcription elongation from RNA polymerase I promoter (GO:0006362)2.92334064
103regulation of translational fidelity (GO:0006450)2.91678262
104pore complex assembly (GO:0046931)2.91211058
105termination of RNA polymerase III transcription (GO:0006386)2.91184058
106transcription elongation from RNA polymerase III promoter (GO:0006385)2.91184058
107spliceosomal snRNP assembly (GO:0000387)2.91083685
108tRNA aminoacylation (GO:0043039)2.90797538
109amino acid activation (GO:0043038)2.90797538
110transferrin transport (GO:0033572)2.90705960
111ATP hydrolysis coupled proton transport (GO:0015991)2.89557396
112energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.89557396
113antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.88595079
114regulation of sister chromatid segregation (GO:0033045)2.88452730
115regulation of mitotic sister chromatid separation (GO:0010965)2.88452730
116regulation of mitotic sister chromatid segregation (GO:0033047)2.88452730
117mitotic recombination (GO:0006312)2.86086609
118regulation of ligase activity (GO:0051340)2.85747552
119IMP metabolic process (GO:0046040)2.85046175
120regulation of DNA endoreduplication (GO:0032875)2.82776324
121regulation of nuclear cell cycle DNA replication (GO:0033262)2.82660716
122COPI coating of Golgi vesicle (GO:0048205)2.80711789
123Golgi transport vesicle coating (GO:0048200)2.80711789
124DNA ligation (GO:0006266)2.80549557
125cytochrome complex assembly (GO:0017004)2.80486311
126synaptic vesicle docking involved in exocytosis (GO:0016081)2.79359281
127DNA replication-independent nucleosome assembly (GO:0006336)2.79232385
128DNA replication-independent nucleosome organization (GO:0034724)2.79232385
129protein neddylation (GO:0045116)2.78081513
130chromosome segregation (GO:0007059)2.77753555
131attachment of spindle microtubules to kinetochore (GO:0008608)2.76405955
132protein localization to kinetochore (GO:0034501)2.76355502
133nuclear envelope organization (GO:0006998)2.76256625
134DNA deamination (GO:0045006)2.75240884
135cellular protein complex localization (GO:0034629)2.74501228
136sister chromatid segregation (GO:0000819)2.74466626
137positive regulation of cell cycle arrest (GO:0071158)2.72244416
138replication fork processing (GO:0031297)2.72220492
139regulation of centrosome cycle (GO:0046605)2.72115570
140regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.71930761
141tRNA aminoacylation for protein translation (GO:0006418)2.71649030
142mitotic cell cycle (GO:0000278)2.71481576
143rRNA processing (GO:0006364)2.70995836
144protein complex localization (GO:0031503)2.70908933
145chaperone-mediated protein transport (GO:0072321)2.70680467
146double-strand break repair via nonhomologous end joining (GO:0006303)2.70626968
147non-recombinational repair (GO:0000726)2.70626968
148negative regulation of dendrite morphogenesis (GO:0050774)2.70598905
149synaptic vesicle exocytosis (GO:0016079)2.70568595
150ribonucleoprotein complex biogenesis (GO:0022613)2.70483419
151protein complex biogenesis (GO:0070271)2.70347771
152mitotic nuclear envelope disassembly (GO:0007077)2.70255547

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.68628071
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.53164006
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.13082971
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.75819606
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.49019568
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.48680680
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.46132480
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.45493466
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.34537957
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.25731713
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.15867798
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.04932908
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78990762
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77875851
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71244465
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.66572288
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.66436772
18* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.66420230
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57194842
20VDR_23849224_ChIP-Seq_CD4+_Human2.45843449
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.43229172
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.37797462
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33881620
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33812157
25ELK1_19687146_ChIP-ChIP_HELA_Human2.33647409
26YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30392321
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26923748
28DCP1A_22483619_ChIP-Seq_HELA_Human2.19635110
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16950554
30* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16166604
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10002581
32XRN2_22483619_ChIP-Seq_HELA_Human2.05679903
33FOXP3_21729870_ChIP-Seq_TREG_Human2.03227115
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.97172797
35TTF2_22483619_ChIP-Seq_HELA_Human1.95571878
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93155952
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91539086
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90942144
39* SRF_21415370_ChIP-Seq_HL-1_Mouse1.88573734
40GABP_19822575_ChIP-Seq_HepG2_Human1.88563688
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85097510
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81321919
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81136422
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72263361
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69357461
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68445470
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.68317896
48AR_21909140_ChIP-Seq_LNCAP_Human1.68083701
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64198690
50ZNF263_19887448_ChIP-Seq_K562_Human1.48229514
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45254394
52FUS_26573619_Chip-Seq_HEK293_Human1.44942672
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42635358
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35916023
55EWS_26573619_Chip-Seq_HEK293_Human1.32105476
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30041288
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29539889
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29323123
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27709936
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.26565015
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23375573
62CIITA_25753668_ChIP-Seq_RAJI_Human1.22262078
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21303422
64TAF15_26573619_Chip-Seq_HEK293_Human1.20727799
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20602323
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20258424
67GBX2_23144817_ChIP-Seq_PC3_Human1.18745610
68TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.18654689
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17451495
70KDM5A_27292631_Chip-Seq_BREAST_Human1.15910440
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15117935
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12672795
73CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08782805
74CHD1_26751641_Chip-Seq_LNCaP_Human1.06855009
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06726432
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02624027
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02587568
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02395152
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02125804
80MYC_18940864_ChIP-ChIP_HL60_Human1.01938064
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00329925
82NANOG_16153702_ChIP-ChIP_HESCs_Human0.97255944
83ELK1_22589737_ChIP-Seq_MCF10A_Human0.96839132
84EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96519219
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95938325
86SALL1_21062744_ChIP-ChIP_HESCs_Human0.95891255
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95659203
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95212037
89NOTCH1_21737748_ChIP-Seq_TLL_Human0.93328839
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93273536
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92509222
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92163464
93ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90096378
94STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89941043
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89465853
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89128433
97TFEB_21752829_ChIP-Seq_HELA_Human0.87980335
98* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87493322
99ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85783249
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.83933047
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83572361
102FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83285184
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82940090
104WT1_19549856_ChIP-ChIP_CCG9911_Human0.82320543
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81914639
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81873792
107TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81744803
108TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.81696120
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80955775
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80885996
111NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80494573
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80180526
113* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.79860070
114HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79451308
115IRF1_19129219_ChIP-ChIP_H3396_Human0.79296648
116SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78381945
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78279013
118REST_19997604_ChIP-ChIP_NEURONS_Mouse0.78200328
119CLOCK_20551151_ChIP-Seq_293T_Human0.77910252
120NANOG_21062744_ChIP-ChIP_HESCs_Human0.77710921
121* JUN_21703547_ChIP-Seq_K562_Human0.77684544
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77560276
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.77532143
124SOX17_20123909_ChIP-Seq_XEN_Mouse0.75706870
125CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75354085
126* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.74493321
127KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.73344425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.88767626
2MP0003693_abnormal_embryo_hatching3.69132287
3MP0010094_abnormal_chromosome_stability3.44796548
4MP0004957_abnormal_blastocyst_morpholog3.37866744
5MP0003111_abnormal_nucleus_morphology3.07867011
6MP0003941_abnormal_skin_development3.05396306
7MP0003123_paternal_imprinting3.04933420
8MP0008877_abnormal_DNA_methylation3.04513944
9MP0008058_abnormal_DNA_repair2.83629045
10MP0008057_abnormal_DNA_replication2.78780759
11MP0001968_abnormal_touch/_nociception2.73788547
12MP0003077_abnormal_cell_cycle2.65832698
13MP0002736_abnormal_nociception_after2.57633746
14MP0008932_abnormal_embryonic_tissue2.40343690
15MP0001188_hyperpigmentation2.31443904
16MP0002735_abnormal_chemical_nociception2.29173246
17MP0009046_muscle_twitch2.24565607
18MP0008007_abnormal_cellular_replicative2.22430394
19* MP0003635_abnormal_synaptic_transmissio2.09798444
20* MP0004859_abnormal_synaptic_plasticity2.07232941
21MP0003122_maternal_imprinting2.01769941
22MP0009745_abnormal_behavioral_response1.97312796
23MP0006276_abnormal_autonomic_nervous1.96473335
24MP0001529_abnormal_vocalization1.91545276
25MP0003121_genomic_imprinting1.91105328
26* MP0009697_abnormal_copulation1.90062673
27MP0002734_abnormal_mechanical_nocicepti1.88013037
28MP0003787_abnormal_imprinting1.80861088
29MP0002063_abnormal_learning/memory/cond1.78436182
30MP0004147_increased_porphyrin_level1.76316137
31MP0002064_seizures1.75946481
32MP0003786_premature_aging1.72991879
33MP0002877_abnormal_melanocyte_morpholog1.67343382
34MP0004270_analgesia1.62776001
35MP0009672_abnormal_birth_weight1.61143404
36MP0003718_maternal_effect1.60324670
37MP0002572_abnormal_emotion/affect_behav1.53748726
38MP0008260_abnormal_autophagy1.53644932
39MP0006035_abnormal_mitochondrial_morpho1.51446375
40MP0001905_abnormal_dopamine_level1.49145632
41MP0003950_abnormal_plasma_membrane1.45302710
42MP0010030_abnormal_orbit_morphology1.45161620
43MP0001986_abnormal_taste_sensitivity1.42148791
44MP0003806_abnormal_nucleotide_metabolis1.36985468
45MP0002396_abnormal_hematopoietic_system1.36799318
46MP0002160_abnormal_reproductive_system1.36338594
47MP0003937_abnormal_limbs/digits/tail_de1.34799914
48MP0000350_abnormal_cell_proliferation1.33552824
49MP0001730_embryonic_growth_arrest1.32828394
50MP0002067_abnormal_sensory_capabilities1.31509318
51MP0001440_abnormal_grooming_behavior1.30946156
52MP0004197_abnormal_fetal_growth/weight/1.30248006
53MP0002272_abnormal_nervous_system1.26597943
54MP0002751_abnormal_autonomic_nervous1.24949624
55MP0002733_abnormal_thermal_nociception1.24353930
56MP0002184_abnormal_innervation1.23046196
57MP0001970_abnormal_pain_threshold1.22260927
58MP0006036_abnormal_mitochondrial_physio1.22176325
59MP0006292_abnormal_olfactory_placode1.21662437
60MP0002876_abnormal_thyroid_physiology1.19567373
61MP0000015_abnormal_ear_pigmentation1.19066965
62MP0002086_abnormal_extraembryonic_tissu1.18389923
63MP0003186_abnormal_redox_activity1.17982477
64MP0003879_abnormal_hair_cell1.17884880
65MP0003385_abnormal_body_wall1.17422466
66MP0004924_abnormal_behavior1.15885076
67MP0005386_behavior/neurological_phenoty1.15885076
68MP0005501_abnormal_skin_physiology1.15879199
69MP0000579_abnormal_nail_morphology1.15393131
70MP0005623_abnormal_meninges_morphology1.13623879
71* MP0004811_abnormal_neuron_physiology1.12349695
72MP0003567_abnormal_fetal_cardiomyocyte1.11752365
73MP0001984_abnormal_olfaction1.10635688
74MP0001501_abnormal_sleep_pattern1.10432425
75MP0003566_abnormal_cell_adhesion1.10403685
76MP0000762_abnormal_tongue_morphology1.09996255
77MP0002796_impaired_skin_barrier1.08746410
78MP0002697_abnormal_eye_size1.08140288
79MP0004272_abnormal_basement_membrane1.07841111
80MP0000358_abnormal_cell_content/1.06056786
81MP0001299_abnormal_eye_distance/1.05370118
82MP0004142_abnormal_muscle_tone1.04707921
83MP0001293_anophthalmia1.04476834
84MP0002234_abnormal_pharynx_morphology1.02762030
85MP0009703_decreased_birth_body1.02495512
86MP0001661_extended_life_span1.01541559
87MP0010234_abnormal_vibrissa_follicle1.00731331
88MP0002177_abnormal_outer_ear1.00206907
89MP0000537_abnormal_urethra_morphology0.99954056
90MP0001542_abnormal_bone_strength0.99897914
91MP0001286_abnormal_eye_development0.99739739
92MP0000647_abnormal_sebaceous_gland0.99366916
93MP0002102_abnormal_ear_morphology0.99024999
94MP0001727_abnormal_embryo_implantation0.98472701
95MP0000372_irregular_coat_pigmentation0.96610125
96MP0005646_abnormal_pituitary_gland0.94782118
97MP0008789_abnormal_olfactory_epithelium0.94679260
98MP0003755_abnormal_palate_morphology0.91833569
99MP0001697_abnormal_embryo_size0.91213860
100MP0002080_prenatal_lethality0.90694713
101MP0005499_abnormal_olfactory_system0.90572286
102MP0005394_taste/olfaction_phenotype0.90572286
103MP0002111_abnormal_tail_morphology0.90129932
104MP0008872_abnormal_physiological_respon0.89104740
105MP0005380_embryogenesis_phenotype0.88696756
106MP0001672_abnormal_embryogenesis/_devel0.88696756
107MP0002060_abnormal_skin_morphology0.88090216
108MP0003221_abnormal_cardiomyocyte_apopto0.87477124
109MP0001486_abnormal_startle_reflex0.86396917
110MP0003646_muscle_fatigue0.86067235
111MP0005389_reproductive_system_phenotype0.85365824
112MP0003935_abnormal_craniofacial_develop0.85262396
113MP0002822_catalepsy0.85022188
114MP0005423_abnormal_somatic_nervous0.84966755
115MP0002163_abnormal_gland_morphology0.83648739
116MP0004185_abnormal_adipocyte_glucose0.82821200
117MP0002233_abnormal_nose_morphology0.82288096
118MP0004215_abnormal_myocardial_fiber0.81929774
119MP0003890_abnormal_embryonic-extraembry0.81539105
120MP0005367_renal/urinary_system_phenotyp0.80756615
121MP0000516_abnormal_urinary_system0.80756615
122MP0004808_abnormal_hematopoietic_stem0.79626287
123MP0004084_abnormal_cardiac_muscle0.79343406
124MP0009379_abnormal_foot_pigmentation0.79145272
125MP0000313_abnormal_cell_death0.78390338
126MP0003984_embryonic_growth_retardation0.77970193
127MP0003119_abnormal_digestive_system0.76569249
128MP0001929_abnormal_gametogenesis0.76250701
129MP0003861_abnormal_nervous_system0.75344622
130MP0002088_abnormal_embryonic_growth/wei0.74745996
131MP0005621_abnormal_cell_physiology0.74587434
132MP0002938_white_spotting0.73641986
133MP0002210_abnormal_sex_determination0.73307823
134MP0008438_abnormal_cutaneous_collagen0.71971236
135MP0002557_abnormal_social/conspecific_i0.70733118
136MP0000428_abnormal_craniofacial_morphol0.69137528
137MP0001216_abnormal_epidermal_layer0.69017330
138MP0003942_abnormal_urinary_system0.68825021
139MP0010307_abnormal_tumor_latency0.68621297
140MP0000627_abnormal_mammary_gland0.68514339
141MP0003315_abnormal_perineum_morphology0.68456720
142MP0003705_abnormal_hypodermis_morpholog0.68324611
143MP0010352_gastrointestinal_tract_polyps0.68149851
144MP0001881_abnormal_mammary_gland0.67927112
145MP0005187_abnormal_penis_morphology0.67168459
146MP0005384_cellular_phenotype0.67085658
147MP0000653_abnormal_sex_gland0.66755999
148MP0008995_early_reproductive_senescence0.65773570
149MP0005076_abnormal_cell_differentiation0.65221137
150* MP0002066_abnormal_motor_capabilities/c0.64806924
151MP0002095_abnormal_skin_pigmentation0.63377970
152MP0000049_abnormal_middle_ear0.63341248
153MP0005171_absent_coat_pigmentation0.63252779
154MP0004233_abnormal_muscle_weight0.62046827
155MP0002019_abnormal_tumor_incidence0.61108427
156MP0005266_abnormal_metabolism0.60582761
157MP0009780_abnormal_chondrocyte_physiolo0.60322206
158MP0002084_abnormal_developmental_patter0.55778544
159MP0001145_abnormal_male_reproductive0.55717226
160MP0002085_abnormal_embryonic_tissue0.54083284

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.97232140
2Focal motor seizures (HP:0011153)3.86346679
3Cortical dysplasia (HP:0002539)3.82732188
4Abnormality of the labia minora (HP:0012880)3.77466287
5Acute necrotizing encephalopathy (HP:0006965)3.30986910
6Abnormal mitochondria in muscle tissue (HP:0008316)3.25585982
7Agnosia (HP:0010524)3.24041167
8Abnormal hair whorl (HP:0010721)3.23918390
9Increased serum pyruvate (HP:0003542)3.20066907
10Abnormality of glycolysis (HP:0004366)3.20066907
11Atonic seizures (HP:0010819)3.17721257
12Increased CSF lactate (HP:0002490)3.14865278
13Epileptic encephalopathy (HP:0200134)3.12210550
14Mitochondrial inheritance (HP:0001427)3.06471781
15Shoulder girdle muscle weakness (HP:0003547)3.04100225
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.99129097
17Abnormality of alanine metabolism (HP:0010916)2.99129097
18Hyperalaninemia (HP:0003348)2.99129097
19Febrile seizures (HP:0002373)2.97198775
20Hepatocellular necrosis (HP:0001404)2.95421117
21Breast hypoplasia (HP:0003187)2.92770614
22Degeneration of anterior horn cells (HP:0002398)2.86350410
23Abnormality of the anterior horn cell (HP:0006802)2.86350410
24Increased nuchal translucency (HP:0010880)2.85857166
25Progressive macrocephaly (HP:0004481)2.85542247
26Cerebral hypomyelination (HP:0006808)2.76723653
27Respiratory difficulties (HP:0002880)2.74966199
28Microvesicular hepatic steatosis (HP:0001414)2.68819397
29Increased serum lactate (HP:0002151)2.64590859
30Embryonal renal neoplasm (HP:0011794)2.59090531
31Selective tooth agenesis (HP:0001592)2.58610243
32Nephroblastoma (Wilms tumor) (HP:0002667)2.57147890
33Increased hepatocellular lipid droplets (HP:0006565)2.57122938
34Multiple enchondromatosis (HP:0005701)2.54383573
35Postnatal microcephaly (HP:0005484)2.46798254
36Gait imbalance (HP:0002141)2.45403412
37Poor suck (HP:0002033)2.42641737
38Exercise intolerance (HP:0003546)2.41857142
39Deviation of the thumb (HP:0009603)2.39401688
40Volvulus (HP:0002580)2.37374583
41Proximal placement of thumb (HP:0009623)2.37118070
42Chromsome breakage (HP:0040012)2.34025004
43Nephrogenic diabetes insipidus (HP:0009806)2.32717047
44Visual hallucinations (HP:0002367)2.31184567
45Absence seizures (HP:0002121)2.31182976
46Congenital primary aphakia (HP:0007707)2.30783981
47Pelvic girdle muscle weakness (HP:0003749)2.29011062
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24207115
49Aplastic anemia (HP:0001915)2.22950030
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.20591267
51Hepatic necrosis (HP:0002605)2.20208974
52Abnormality of the hip-girdle musculature (HP:0001445)2.19757813
53Abnormality of the musculature of the pelvis (HP:0001469)2.19757813
54Type 2 muscle fiber atrophy (HP:0003554)2.19726559
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18904740
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18173718
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18173718
58Acute encephalopathy (HP:0006846)2.18060698
59Insidious onset (HP:0003587)2.15896607
60Termporal pattern (HP:0011008)2.15896607
61Type I transferrin isoform profile (HP:0003642)2.14307865
62Focal seizures (HP:0007359)2.13512523
63Dialeptic seizures (HP:0011146)2.13334064
64Neuroendocrine neoplasm (HP:0100634)2.12773867
65Abnormality of methionine metabolism (HP:0010901)2.11395999
66Lactic acidosis (HP:0003128)2.11167818
67Abnormal gallbladder physiology (HP:0012438)2.10411498
68Cholecystitis (HP:0001082)2.10411498
69Generalized tonic-clonic seizures (HP:0002069)2.09483249
70Atrophy/Degeneration involving motor neurons (HP:0007373)2.09085094
71Unsteady gait (HP:0002317)2.08777520
72Myokymia (HP:0002411)2.07492858
73Patellar aplasia (HP:0006443)2.07471056
74Overlapping toe (HP:0001845)2.06511818
753-Methylglutaconic aciduria (HP:0003535)2.05865324
76Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05601717
77Abnormality of the umbilical cord (HP:0010881)2.05503216
78Neuroblastic tumors (HP:0004376)2.05046002
79Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.05046002
80Neuroblastoma (HP:0003006)2.05046002
81Primitive neuroectodermal tumor (HP:0030065)2.05046002
82Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04620802
83Lipid accumulation in hepatocytes (HP:0006561)2.04408112
84Pheochromocytoma (HP:0002666)2.03622573
85Medial flaring of the eyebrow (HP:0010747)2.03318290
86Rhabdomyosarcoma (HP:0002859)2.01653134
87Trismus (HP:0000211)1.99501731
88Hypoplasia of the pons (HP:0012110)1.99147676
89Hypothermia (HP:0002045)1.96745218
90Meckel diverticulum (HP:0002245)1.96057276
91Microglossia (HP:0000171)1.95652797
92Myelodysplasia (HP:0002863)1.95538973
93Deep philtrum (HP:0002002)1.93953532
94Abnormality of the preputium (HP:0100587)1.93628903
95Muscle fiber atrophy (HP:0100295)1.93159312
96Irregular epiphyses (HP:0010582)1.92514302
97Abnormality of the fetal cardiovascular system (HP:0010948)1.92282106
98Abnormal umbilical cord blood vessels (HP:0011403)1.92282106
99Single umbilical artery (HP:0001195)1.92282106
100Aplasia/Hypoplasia of the patella (HP:0006498)1.92019687
101Abnormality of the duodenum (HP:0002246)1.91290855
102Ankyloglossia (HP:0010296)1.89926241
103Emotional lability (HP:0000712)1.89575462
104Facial cleft (HP:0002006)1.89264696
105Abnormality of chromosome stability (HP:0003220)1.89234657
106Secondary amenorrhea (HP:0000869)1.87551642
107Impaired pain sensation (HP:0007328)1.87525648
108Abnormality of pain sensation (HP:0010832)1.87525648
109Entropion (HP:0000621)1.87269717
110Exercise-induced muscle cramps (HP:0003710)1.87120168
111Abnormalities of placenta or umbilical cord (HP:0001194)1.86817890
112Progressive muscle weakness (HP:0003323)1.86633267
113Delusions (HP:0000746)1.85664722
114Fetal akinesia sequence (HP:0001989)1.84681541
115Poor head control (HP:0002421)1.84272184
116Abnormality of the ileum (HP:0001549)1.84108114
117Medulloblastoma (HP:0002885)1.83962075
118Choanal atresia (HP:0000453)1.83876419
119Poor coordination (HP:0002370)1.82948211
120Prominent metopic ridge (HP:0005487)1.81980577
121Neoplasm of the colon (HP:0100273)1.81456038
122Protruding tongue (HP:0010808)1.81289879
123Spastic diplegia (HP:0001264)1.81175869
124Oral leukoplakia (HP:0002745)1.77564810
125CNS hypomyelination (HP:0003429)1.77563424
126Colon cancer (HP:0003003)1.76637419
127CNS demyelination (HP:0007305)1.76212286
128Hypokinesia (HP:0002375)1.76028097
129Pancreatic fibrosis (HP:0100732)1.75773477
130Progressive cerebellar ataxia (HP:0002073)1.75753046
131Respiratory failure (HP:0002878)1.75723307
132Absent radius (HP:0003974)1.75244399
133Carpal bone hypoplasia (HP:0001498)1.74525043
134Hypoplastic pelvis (HP:0008839)1.74262144
135Abnormality of placental membranes (HP:0011409)1.73925627
136Amniotic constriction ring (HP:0009775)1.73925627
137Heterochromia iridis (HP:0001100)1.73514748
138Abnormal lung lobation (HP:0002101)1.72866861
139Hyperventilation (HP:0002883)1.72555257
140Duodenal stenosis (HP:0100867)1.71708300
141Small intestinal stenosis (HP:0012848)1.71708300
142Tongue fasciculations (HP:0001308)1.71688310
143Upper limb muscle weakness (HP:0003484)1.71598817
144Horseshoe kidney (HP:0000085)1.70602903
145Abnormality of the heme biosynthetic pathway (HP:0010472)1.70408002
146Neoplasm of the peripheral nervous system (HP:0100007)1.70159091
147Papillary thyroid carcinoma (HP:0002895)1.69969182
148Premature rupture of membranes (HP:0001788)1.68848239
149Abnormality of the carotid arteries (HP:0005344)1.64098928
150Ependymoma (HP:0002888)1.63776780
151Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.62850981
152Limb-girdle muscle atrophy (HP:0003797)1.62307308
153Abnormal auditory evoked potentials (HP:0006958)1.61095079
154Aplasia/Hypoplasia of the sacrum (HP:0008517)1.60760129
155Onycholysis (HP:0001806)1.58584250
156Reduced subcutaneous adipose tissue (HP:0003758)1.57479136
157Aplasia involving forearm bones (HP:0009822)1.55052647
158Absent forearm bone (HP:0003953)1.55052647
159Abnormal protein glycosylation (HP:0012346)1.54996561
160Abnormal glycosylation (HP:0012345)1.54996561
161Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.54996561
162Abnormal protein N-linked glycosylation (HP:0012347)1.54996561
163Abnormality of the metopic suture (HP:0005556)1.53711299
164Cafe-au-lait spot (HP:0000957)1.53598884
165Ankle contracture (HP:0006466)1.53073030
166Neoplasm of the rectum (HP:0100743)1.52913737
167Abnormal number of incisors (HP:0011064)1.52098081
168Orthostatic hypotension (HP:0001278)1.51136702
169Poikiloderma (HP:0001029)1.48427153
170Septate vagina (HP:0001153)1.47339370
171Sparse eyelashes (HP:0000653)1.45904133
172Neoplasm of the small intestine (HP:0100833)1.44539011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.63635650
2BUB13.52686917
3CASK3.38779019
4TSSK63.18908731
5MAP3K123.02903355
6NEK13.02442487
7PBK2.91077010
8WEE12.77149791
9ACVR1B2.48228411
10CCNB12.32173023
11PLK22.28095647
12EIF2AK32.23657711
13MST42.22433857
14MAP2K72.21527786
15CDC72.15408643
16PLK32.05185931
17STK162.01026434
18VRK21.98170017
19AKT31.91777407
20TRIM281.89502276
21PLK41.85032340
22BRSK11.79859001
23TAF11.77559120
24NTRK31.67650589
25BRSK21.67415191
26SRPK11.62673188
27MKNK11.59423329
28MINK11.58588352
29DAPK11.56133627
30MAP3K41.53633063
31MKNK21.50371980
32PAK41.43945347
33CDK121.40998089
34CDK81.38277991
35VRK11.31617107
36PLK11.31532058
37PNCK1.29112898
38ZAK1.22749357
39BMPR1B1.22629999
40PDK41.21754190
41PDK31.21754190
42ARAF1.18955868
43CDK71.16963038
44NME11.14810300
45MET1.14798410
46LATS11.12431702
47CDK191.12199569
48MST1R1.10943626
49BRAF1.07241893
50DYRK31.06732545
51SCYL21.05909926
52NME21.02044870
53MARK11.01300210
54ERBB40.99773022
55SMG10.99288002
56LIMK10.96998818
57TTK0.95972878
58MAP2K40.94678941
59ERBB30.90301574
60MUSK0.90015068
61CAMKK20.87381814
62AURKA0.85365717
63RPS6KA40.83086443
64KSR10.82737643
65SIK30.82104028
66FLT30.81909700
67STK240.81267492
68NUAK10.81162632
69PTK20.81105516
70STK30.79108704
71MAP3K90.78936531
72PIM20.78374182
73EIF2AK20.78175624
74TGFBR10.77559310
75BRD40.76455340
76MAP3K80.76340035
77PDK20.75389385
78LATS20.75288426
79PRPF4B0.74530457
80EPHA40.73539486
81PRKCG0.73079921
82AURKB0.72203110
83CLK10.67946420
84ATR0.66422433
85TESK10.65911892
86CSNK1G10.64476823
87ATM0.64345329
88DMPK0.62014248
89NTRK10.61586424
90CSNK1A1L0.60947805
91CDK140.58987852
92* CDK10.58980502
93GRK50.58275852
94CDK180.57930342
95IRAK30.54846888
96PDGFRA0.54433744
97STK100.53733415
98CSNK1E0.53061735
99FGFR10.53040938
100MYLK0.52200211
101CSNK2A10.52167958
102TAOK20.52154220
103DAPK20.49964486
104CDK150.48204357
105BMPR20.46689261
106CHEK20.46533687
107CSNK2A20.45642536
108BCR0.45473503
109YES10.45346604
110PAK20.45192420
111ALK0.44277891
112PRKCI0.44074630
113CDK11A0.43929760
114AKT20.43819564
115EPHA20.43631408
116CDK90.43562571
117KSR20.43520272
118MAPK130.43341351
119PASK0.43083723
120CHEK10.42805139
121STK38L0.42242641
122RAF10.40755045
123MELK0.40674179
124RPS6KB10.39080967
125FES0.38620160
126RPS6KB20.38116088
127RIPK40.37169928
128CSNK1G30.36916624
129MAP3K50.36255628
130ADRBK10.35421275
131SGK20.35304254
132NEK90.34042538
133TESK20.33078608
134NEK20.32540606
135CSNK1G20.32429548
136PAK10.31486947
137CDK20.30127336
138FRK0.28832113
139CAMK2A0.28171962

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.86266506
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.46805108
3DNA replication_Homo sapiens_hsa030303.41006257
4Mismatch repair_Homo sapiens_hsa034303.10478348
5RNA polymerase_Homo sapiens_hsa030202.86886264
6Synaptic vesicle cycle_Homo sapiens_hsa047212.66210119
7RNA transport_Homo sapiens_hsa030132.63618360
8Homologous recombination_Homo sapiens_hsa034402.44579544
9Collecting duct acid secretion_Homo sapiens_hsa049662.38041903
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38022838
11Oxidative phosphorylation_Homo sapiens_hsa001902.28501614
12Nucleotide excision repair_Homo sapiens_hsa034202.25657516
13Base excision repair_Homo sapiens_hsa034102.25074891
14Nicotine addiction_Homo sapiens_hsa050332.15627404
15Spliceosome_Homo sapiens_hsa030402.11919111
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.11567677
17Cell cycle_Homo sapiens_hsa041102.10505126
18Pyrimidine metabolism_Homo sapiens_hsa002401.93464891
19Parkinsons disease_Homo sapiens_hsa050121.89708896
20RNA degradation_Homo sapiens_hsa030181.71057665
21Vibrio cholerae infection_Homo sapiens_hsa051101.67045673
22Basal transcription factors_Homo sapiens_hsa030221.64776066
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62366330
24Ribosome_Homo sapiens_hsa030101.58503423
25Huntingtons disease_Homo sapiens_hsa050161.56933422
26Oocyte meiosis_Homo sapiens_hsa041141.54883405
27Non-homologous end-joining_Homo sapiens_hsa034501.54284050
28Fatty acid elongation_Homo sapiens_hsa000621.51712512
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.38559697
30Steroid biosynthesis_Homo sapiens_hsa001001.37045907
31Fanconi anemia pathway_Homo sapiens_hsa034601.36490681
32Purine metabolism_Homo sapiens_hsa002301.34204701
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31784991
34Folate biosynthesis_Homo sapiens_hsa007901.27521892
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22874785
36Selenocompound metabolism_Homo sapiens_hsa004501.21362055
37One carbon pool by folate_Homo sapiens_hsa006701.17314706
38Alzheimers disease_Homo sapiens_hsa050101.16586809
39mRNA surveillance pathway_Homo sapiens_hsa030151.09127061
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06345020
41Epstein-Barr virus infection_Homo sapiens_hsa051691.03508627
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02895566
43Propanoate metabolism_Homo sapiens_hsa006401.00285346
44Olfactory transduction_Homo sapiens_hsa047400.98522782
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98131656
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95919146
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95215387
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92922123
49Amphetamine addiction_Homo sapiens_hsa050310.92331335
50Phagosome_Homo sapiens_hsa041450.89451586
51Vitamin B6 metabolism_Homo sapiens_hsa007500.87229358
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86347207
53p53 signaling pathway_Homo sapiens_hsa041150.85354396
54Long-term potentiation_Homo sapiens_hsa047200.85149403
55GABAergic synapse_Homo sapiens_hsa047270.84849364
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84320753
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83749747
58Regulation of autophagy_Homo sapiens_hsa041400.82597340
59Fructose and mannose metabolism_Homo sapiens_hsa000510.82577594
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.81769054
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81405004
62Adherens junction_Homo sapiens_hsa045200.80328533
63Dopaminergic synapse_Homo sapiens_hsa047280.79162530
64Sulfur relay system_Homo sapiens_hsa041220.77912318
65Morphine addiction_Homo sapiens_hsa050320.77629286
66Rheumatoid arthritis_Homo sapiens_hsa053230.76111817
67Biosynthesis of amino acids_Homo sapiens_hsa012300.75835677
68Hippo signaling pathway_Homo sapiens_hsa043900.71625183
69Circadian entrainment_Homo sapiens_hsa047130.71340965
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69736026
71Glutathione metabolism_Homo sapiens_hsa004800.69100520
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68384237
73Fatty acid metabolism_Homo sapiens_hsa012120.64316359
74Taste transduction_Homo sapiens_hsa047420.63686064
75N-Glycan biosynthesis_Homo sapiens_hsa005100.62927835
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62069381
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60899384
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60326831
79Type I diabetes mellitus_Homo sapiens_hsa049400.60270695
80Carbon metabolism_Homo sapiens_hsa012000.59530033
81Cardiac muscle contraction_Homo sapiens_hsa042600.59149392
82Serotonergic synapse_Homo sapiens_hsa047260.58825797
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56702954
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56027185
85Arginine and proline metabolism_Homo sapiens_hsa003300.53603113
86Bladder cancer_Homo sapiens_hsa052190.53332404
87MicroRNAs in cancer_Homo sapiens_hsa052060.51586451
88TGF-beta signaling pathway_Homo sapiens_hsa043500.51418067
89Long-term depression_Homo sapiens_hsa047300.50358045
90Lysine degradation_Homo sapiens_hsa003100.49715030
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49270714
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48354946
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47324615
94Sulfur metabolism_Homo sapiens_hsa009200.46483991
95Alcoholism_Homo sapiens_hsa050340.45649512
96Tight junction_Homo sapiens_hsa045300.45374984
97Protein export_Homo sapiens_hsa030600.45062339
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44260512
99Legionellosis_Homo sapiens_hsa051340.44252501
100Glutamatergic synapse_Homo sapiens_hsa047240.43273529
101Wnt signaling pathway_Homo sapiens_hsa043100.42909854
102Gap junction_Homo sapiens_hsa045400.42855179
103Thyroid cancer_Homo sapiens_hsa052160.40331253
104Small cell lung cancer_Homo sapiens_hsa052220.39985308
105Calcium signaling pathway_Homo sapiens_hsa040200.39388607
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39363913
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38867005
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32997725
109HIF-1 signaling pathway_Homo sapiens_hsa040660.32990851
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32100647
111Pentose phosphate pathway_Homo sapiens_hsa000300.31342220
112Colorectal cancer_Homo sapiens_hsa052100.30617240
113Chronic myeloid leukemia_Homo sapiens_hsa052200.30254031
114Prostate cancer_Homo sapiens_hsa052150.29856413
115Cholinergic synapse_Homo sapiens_hsa047250.28470018
116Oxytocin signaling pathway_Homo sapiens_hsa049210.28000920
117Basal cell carcinoma_Homo sapiens_hsa052170.27789709
118Pancreatic cancer_Homo sapiens_hsa052120.27661899
119Hedgehog signaling pathway_Homo sapiens_hsa043400.27457146
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27298931
121Melanoma_Homo sapiens_hsa052180.27067015
122Shigellosis_Homo sapiens_hsa051310.26539646
123Proteoglycans in cancer_Homo sapiens_hsa052050.26317075
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26316193
125Viral carcinogenesis_Homo sapiens_hsa052030.25761819
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22633462
127Pyruvate metabolism_Homo sapiens_hsa006200.22361292
128Metabolic pathways_Homo sapiens_hsa011000.21597173
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21007814
130AMPK signaling pathway_Homo sapiens_hsa041520.18126480
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.17403338
132Renal cell carcinoma_Homo sapiens_hsa052110.16584963
133Antigen processing and presentation_Homo sapiens_hsa046120.16051771
134Fatty acid biosynthesis_Homo sapiens_hsa000610.15720620
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15455783
136Renin-angiotensin system_Homo sapiens_hsa046140.13858425
137Insulin secretion_Homo sapiens_hsa049110.13788028
138Galactose metabolism_Homo sapiens_hsa000520.13572689
139HTLV-I infection_Homo sapiens_hsa051660.12694067
140Renin secretion_Homo sapiens_hsa049240.11310508
141Salivary secretion_Homo sapiens_hsa049700.10430739
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.09772587

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