USP15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.37786153
2regulation of B cell receptor signaling pathway (GO:0050855)5.60796298
3nuclear pore complex assembly (GO:0051292)5.48481189
4negative regulation of cell killing (GO:0031342)5.43029736
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.43029736
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.32069909
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.17188455
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.17188455
9modulation by symbiont of host immune response (GO:0052553)5.17188455
10positive regulation by symbiont of host defense response (GO:0052509)5.17188455
11modulation by symbiont of host defense response (GO:0052031)5.17188455
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.17188455
13nuclear pore organization (GO:0006999)5.12257378
14detection of molecule of bacterial origin (GO:0032490)5.04494923
15regulation of gamma-delta T cell activation (GO:0046643)4.59160018
16positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.58948101
17mitotic chromosome condensation (GO:0007076)4.58908253
18mitotic metaphase plate congression (GO:0007080)4.56844488
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.54565905
20macrophage activation involved in immune response (GO:0002281)4.51580989
21neutrophil activation involved in immune response (GO:0002283)4.49962161
22microglial cell activation (GO:0001774)4.49608401
23meiotic chromosome segregation (GO:0045132)4.41570580
24regulation of gamma-delta T cell differentiation (GO:0045586)4.39673701
25cellular extravasation (GO:0045123)4.39595056
26mitotic sister chromatid cohesion (GO:0007064)4.38226943
27pore complex assembly (GO:0046931)4.32223267
28mitotic sister chromatid segregation (GO:0000070)4.28919170
29attachment of spindle microtubules to kinetochore (GO:0008608)4.28504222
30detection of other organism (GO:0098543)4.24487316
31mitotic nuclear envelope disassembly (GO:0007077)4.21313195
32detection of external biotic stimulus (GO:0098581)4.17764685
33negative regulation of T cell mediated immunity (GO:0002710)4.05883695
34protein localization to chromosome, centromeric region (GO:0071459)4.05754783
35protein localization to kinetochore (GO:0034501)4.04813787
36regulation of interferon-beta biosynthetic process (GO:0045357)4.04323066
37metaphase plate congression (GO:0051310)4.01692829
38sister chromatid segregation (GO:0000819)4.00497993
39antigen processing and presentation of endogenous antigen (GO:0019883)3.99664852
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.99236717
41nuclear envelope disassembly (GO:0051081)3.98377981
42membrane disassembly (GO:0030397)3.98377981
43B cell receptor signaling pathway (GO:0050853)3.98125340
44* monoubiquitinated protein deubiquitination (GO:0035520)3.97661237
45negative regulation of interleukin-12 production (GO:0032695)3.97609632
46positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.96258927
47negative regulation of lymphocyte mediated immunity (GO:0002707)3.93867014
48establishment of chromosome localization (GO:0051303)3.91004832
49macrophage activation (GO:0042116)3.88067937
50sperm-egg recognition (GO:0035036)3.86616458
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.86595586
52positive regulation of mitotic sister chromatid separation (GO:1901970)3.86286627
53positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.86286627
54positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.86286627
55response to peptidoglycan (GO:0032494)3.86224560
56binding of sperm to zona pellucida (GO:0007339)3.85092071
57neutrophil mediated immunity (GO:0002446)3.84758838
58positive regulation of granulocyte differentiation (GO:0030854)3.84597277
59fusion of sperm to egg plasma membrane (GO:0007342)3.78956138
60response to interleukin-15 (GO:0070672)3.78792126
61regulation of centriole replication (GO:0046599)3.77259506
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.75491408
63response to host immune response (GO:0052572)3.75491408
64positive regulation of B cell differentiation (GO:0045579)3.75463549
65kinetochore organization (GO:0051383)3.75434725
66piRNA metabolic process (GO:0034587)3.72936822
67regulation of spindle organization (GO:0090224)3.72887233
68detection of biotic stimulus (GO:0009595)3.68900015
69multicellular organism reproduction (GO:0032504)3.68452284
70detection of bacterium (GO:0016045)3.68083614
71negative T cell selection (GO:0043383)3.65761119
72chromatin remodeling at centromere (GO:0031055)3.65733403
73CENP-A containing nucleosome assembly (GO:0034080)3.64007760
74DNA replication initiation (GO:0006270)3.62866786
75histone exchange (GO:0043486)3.61517152
76regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.61326175
77positive regulation of chromosome segregation (GO:0051984)3.59895664
78negative thymic T cell selection (GO:0045060)3.59305303
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.58503083
80neutrophil activation (GO:0042119)3.55197921
81myeloid cell activation involved in immune response (GO:0002275)3.52031088
82regulation of B cell differentiation (GO:0045577)3.51249559
83DNA replication checkpoint (GO:0000076)3.48685628
84cell-cell recognition (GO:0009988)3.48551700
85myeloid leukocyte mediated immunity (GO:0002444)3.47398208
86positive T cell selection (GO:0043368)3.46748132
87male meiosis (GO:0007140)3.44310467
88microtubule depolymerization (GO:0007019)3.43530587
89sister chromatid cohesion (GO:0007062)3.40133673
90DNA replication-independent nucleosome organization (GO:0034724)3.40076807
91DNA replication-independent nucleosome assembly (GO:0006336)3.40076807
92leukocyte aggregation (GO:0070486)3.39726224
93cellular response to interleukin-15 (GO:0071350)3.39175020
94hepatocyte apoptotic process (GO:0097284)3.39054752
95response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37462118
96response to host (GO:0075136)3.37462118
97response to host defenses (GO:0052200)3.37462118
98acrosome assembly (GO:0001675)3.36776595
99regulation of chromosome segregation (GO:0051983)3.34526712
100chromosome condensation (GO:0030261)3.34178763
101regulation of mitotic spindle organization (GO:0060236)3.33804287
102positive thymic T cell selection (GO:0045059)3.30156543
103respiratory burst (GO:0045730)3.29449879
104positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.29087615
105regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.28860283
106chromosome segregation (GO:0007059)3.28510700
107negative regulation of leukocyte mediated immunity (GO:0002704)3.26468467
108DNA replication-dependent nucleosome organization (GO:0034723)3.24474247
109DNA replication-dependent nucleosome assembly (GO:0006335)3.24474247
110protein K6-linked ubiquitination (GO:0085020)3.23761048
111immunoglobulin mediated immune response (GO:0016064)3.23583681
112negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.22807473
113activated T cell proliferation (GO:0050798)3.22325183
114IMP biosynthetic process (GO:0006188)3.21090381
115cellular response to ethanol (GO:0071361)3.21083232
116negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.20202461
117T cell migration (GO:0072678)3.19862729
118DNA packaging (GO:0006323)3.18818379
119regulation of centrosome cycle (GO:0046605)3.18692027
120granulocyte activation (GO:0036230)3.18082213
121IMP metabolic process (GO:0046040)3.16660008
122regulation of alpha-beta T cell proliferation (GO:0046640)3.15052420
123positive regulation of interferon-alpha production (GO:0032727)3.15024267
124negative regulation of B cell proliferation (GO:0030889)3.10592380
125protein localization to chromosome (GO:0034502)3.10087116
126purine nucleobase biosynthetic process (GO:0009113)3.09024579
127negative regulation of adaptive immune response (GO:0002820)3.08951855
128phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.08414577
129nucleobase biosynthetic process (GO:0046112)3.08104376
130telomere maintenance via recombination (GO:0000722)3.07701243
131regulation of mitotic metaphase/anaphase transition (GO:0030071)3.07640864
132spindle checkpoint (GO:0031577)3.07430027
133regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.07414524
134negative regulation of T-helper cell differentiation (GO:0045623)3.07331308
135negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.07331308
136cell wall macromolecule catabolic process (GO:0016998)3.07318223
137cell wall macromolecule metabolic process (GO:0044036)3.07318223
138regulation of histone H3-K9 methylation (GO:0051570)3.06657307
139production of molecular mediator involved in inflammatory response (GO:0002532)3.06451566
140regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.05868023
141DNA strand elongation involved in DNA replication (GO:0006271)3.05243256
142regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.02702194
143defense response to protozoan (GO:0042832)3.02460692
144synaptonemal complex assembly (GO:0007130)3.02008241
145positive regulation of mast cell activation (GO:0033005)3.01854726
146regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01300664
147regulation of mitotic spindle checkpoint (GO:1903504)3.01300664
148kinetochore assembly (GO:0051382)3.01018815
149interferon-gamma production (GO:0032609)3.00564225
150mismatch repair (GO:0006298)3.00300184
151regulation of interferon-alpha production (GO:0032647)3.00174506
152chromatin assembly or disassembly (GO:0006333)3.00142782
153nuclear envelope organization (GO:0006998)3.00091062
154regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99633710
155leukocyte degranulation (GO:0043299)2.99537306
156regulation of mast cell activation (GO:0033003)2.99386223
157reproduction (GO:0000003)2.97534133
158DNA synthesis involved in DNA repair (GO:0000731)2.97360709
159meiotic cell cycle (GO:0051321)2.97213117
160regulation of sister chromatid segregation (GO:0033045)2.96075220
161regulation of mitotic sister chromatid separation (GO:0010965)2.96075220
162regulation of mitotic sister chromatid segregation (GO:0033047)2.96075220
163cellular response to type I interferon (GO:0071357)2.94662414
164type I interferon signaling pathway (GO:0060337)2.94662414
165germinal center formation (GO:0002467)2.94610066
166regulation of mast cell degranulation (GO:0043304)2.93823340
167regulation of sister chromatid cohesion (GO:0007063)2.93631461
168response to type I interferon (GO:0034340)2.93496581
169regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.93409226
170regulation of interleukin-12 biosynthetic process (GO:0045075)2.92957462
171telomere maintenance via semi-conservative replication (GO:0032201)2.92098907
172mitotic recombination (GO:0006312)2.90848010
173maturation of 5.8S rRNA (GO:0000460)2.90786510
174negative regulation of histone methylation (GO:0031061)2.90122390
175negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.89621686
176T cell selection (GO:0045058)2.88649353
177negative regulation of mitotic sister chromatid separation (GO:2000816)2.87888725
178negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87888725
179negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87888725
180negative regulation of sister chromatid segregation (GO:0033046)2.87888725
181folic acid-containing compound biosynthetic process (GO:0009396)2.87604866
182gene silencing by RNA (GO:0031047)2.87239252
183DNA strand elongation (GO:0022616)2.87152804
184negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86175406
185negative regulation of chromosome segregation (GO:0051985)2.86010789
186meiotic nuclear division (GO:0007126)2.86004181
187regulation of tolerance induction (GO:0002643)2.85226412
188antigen processing and presentation via MHC class Ib (GO:0002475)2.84436910
189interferon-gamma-mediated signaling pathway (GO:0060333)2.84286352
190maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.83626940
191regulation of mast cell activation involved in immune response (GO:0033006)2.83578695
192DNA unwinding involved in DNA replication (GO:0006268)2.83138743
193cilium or flagellum-dependent cell motility (GO:0001539)2.83052876
194synaptonemal complex organization (GO:0070193)2.82898105
195negative regulation of erythrocyte differentiation (GO:0045647)2.82798567
196negative regulation of B cell mediated immunity (GO:0002713)2.81886886
197negative regulation of immunoglobulin mediated immune response (GO:0002890)2.81886886
198dendritic cell migration (GO:0036336)2.81388720
199histone H2A monoubiquitination (GO:0035518)2.81200216
200positive regulation of interferon-beta production (GO:0032728)2.80905323

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.02429893
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.89662082
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.19764485
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.95239455
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.88985868
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.45606172
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.36971885
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.10935675
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.07713304
10RUNX_20019798_ChIP-Seq_JUKART_Human3.00396695
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91869811
12* MYC_18555785_ChIP-Seq_MESCs_Mouse2.52942599
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.51535936
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.47582919
15AR_21909140_ChIP-Seq_LNCAP_Human2.39727294
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.38776375
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.36160506
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.36004869
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.26833876
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.24639490
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21021557
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19229720
23SPI1_23127762_ChIP-Seq_K562_Human2.11011082
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.08725651
25* EST1_17652178_ChIP-ChIP_JURKAT_Human2.03058730
26VDR_24787735_ChIP-Seq_THP-1_Human1.94033978
27GATA3_27048872_Chip-Seq_THYMUS_Human1.93610656
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91442053
29VDR_23849224_ChIP-Seq_CD4+_Human1.86631429
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.86532680
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85220713
32* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84561006
33* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.80952017
34GATA3_26560356_Chip-Seq_TH2_Human1.76393983
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75370969
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.73853937
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73439801
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.71762708
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65944775
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64042109
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62581834
42ELK1_19687146_ChIP-ChIP_HELA_Human1.62436175
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.61493443
44VDR_24763502_ChIP-Seq_THP-1_Human1.60643255
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59860675
46GATA1_19941826_ChIP-Seq_K562_Human1.59039352
47* MAF_26560356_Chip-Seq_TH1_Human1.57080047
48* FOXP3_21729870_ChIP-Seq_TREG_Human1.56972710
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55503656
50* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.55033968
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54348615
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54343032
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.54243286
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53770805
55* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53096449
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.51874672
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45250215
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45134081
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44036528
60* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43505410
61GABP_19822575_ChIP-Seq_HepG2_Human1.43018986
62GATA2_19941826_ChIP-Seq_K562_Human1.42700197
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42330115
64* PU_27001747_Chip-Seq_BMDM_Mouse1.42163819
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.40598473
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39411035
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38633729
68* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37926015
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37205767
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.34886501
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33692193
72* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31324729
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.28994350
74KDM5A_27292631_Chip-Seq_BREAST_Human1.28981219
75DCP1A_22483619_ChIP-Seq_HELA_Human1.28758089
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27605202
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25293335
78* UTX_26944678_Chip-Seq_JUKART_Human1.22701476
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.22658761
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21180215
81MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21031027
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20378011
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19398929
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19216420
85* MYC_22102868_ChIP-Seq_BL_Human1.18674062
86* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17893405
87XRN2_22483619_ChIP-Seq_HELA_Human1.16473788
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15168544
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14346041
90* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14040351
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13026758
92KAP1_22055183_ChIP-Seq_ESCs_Mouse1.12927485
93TFEB_21752829_ChIP-Seq_HELA_Human1.12290611
94CIITA_25753668_ChIP-Seq_RAJI_Human1.11902414
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.11573672
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10823177
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.09637652
98* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09525692
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09254015
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08245206
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.07842327
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07009773
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06671453
104SMRT_27268052_Chip-Seq_Bcells_Human1.06492986
105KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.04821156
106SALL4_22934838_ChIP-ChIP_CD34+_Human1.03578208
107STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02736566
108* ER_23166858_ChIP-Seq_MCF-7_Human1.01723774
109POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00221535
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99751058
111* SPI1_23547873_ChIP-Seq_NB4_Human0.99535141
112HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97084794
113PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97021180
114HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96938618
115MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96718392
116* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96028129
117MYB_26560356_Chip-Seq_TH2_Human0.95949454
118GATA3_26560356_Chip-Seq_TH1_Human0.94231208
119* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94073341
120THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93601364
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93052568
122SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92988677
123MYC_18940864_ChIP-ChIP_HL60_Human0.92976074
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.92699339
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91026504
126TTF2_22483619_ChIP-Seq_HELA_Human0.90010197
127EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89214947
128VDR_21846776_ChIP-Seq_THP-1_Human0.87056449
129TCF7_22412390_ChIP-Seq_EML_Mouse0.86937922
130MAF_26560356_Chip-Seq_TH2_Human0.86487725
131MYB_26560356_Chip-Seq_TH1_Human0.86136246
132GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85221821
133VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84972912
134STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84940915
135GATA1_22025678_ChIP-Seq_K562_Human0.84793573
136PRDM14_20953172_ChIP-Seq_ESCs_Human0.84762863
137CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83607724
138CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82598036
139OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82152264
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81815620
141SCL_19346495_ChIP-Seq_HPC-7_Human0.81611851
142* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81340087
143IGF1R_20145208_ChIP-Seq_DFB_Human0.81229437
144NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80790185
145FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80507113
146DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80326716
147SUZ12_27294783_Chip-Seq_NPCs_Mouse0.79487898
148* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79203525
149* FLI1_21867929_ChIP-Seq_TH2_Mouse0.79042512
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78969617
151NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.77444445
152CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76829653
153TP63_19390658_ChIP-ChIP_HaCaT_Human0.76559718
154KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.76041581
155* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75787675
156NFE2_27457419_Chip-Seq_LIVER_Mouse0.75459699
157ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.75196766
158BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75188907
159* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.75155352
160SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74830629
161PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74787928
162* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.74608097
163CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.73711211
164GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72950556
165NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.72514830
166* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.71607056
167HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.71367467
168IRF8_27001747_Chip-Seq_BMDM_Mouse0.70991168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.40713771
2MP0010094_abnormal_chromosome_stability4.35731829
3MP0003693_abnormal_embryo_hatching4.19463189
4MP0003077_abnormal_cell_cycle3.60397707
5MP0003111_abnormal_nucleus_morphology3.60185363
6MP0008057_abnormal_DNA_replication3.41958393
7MP0008877_abnormal_DNA_methylation3.38567536
8MP0008058_abnormal_DNA_repair3.08962593
9MP0004957_abnormal_blastocyst_morpholog3.02208929
10MP0003436_decreased_susceptibility_to3.02154631
11MP0003303_peritoneal_inflammation2.98744381
12MP0008007_abnormal_cellular_replicative2.80406788
13MP0010307_abnormal_tumor_latency2.75063117
14MP0005410_abnormal_fertilization2.61121715
15MP0002419_abnormal_innate_immunity2.60278377
16MP0003646_muscle_fatigue2.51813111
17MP0003656_abnormal_erythrocyte_physiolo2.48440503
18MP0002396_abnormal_hematopoietic_system2.41738527
19MP0001790_abnormal_immune_system2.28086032
20MP0005387_immune_system_phenotype2.28086032
21MP0008260_abnormal_autophagy2.27254498
22MP0002166_altered_tumor_susceptibility2.20405862
23MP0004147_increased_porphyrin_level2.12920175
24MP0001929_abnormal_gametogenesis2.10332938
25MP0004808_abnormal_hematopoietic_stem2.02861869
26MP0006082_CNS_inflammation2.01134704
27MP0002148_abnormal_hypersensitivity_rea1.99675923
28MP0010352_gastrointestinal_tract_polyps1.91724844
29MP0001730_embryonic_growth_arrest1.89730398
30MP0003300_gastrointestinal_ulcer1.88346692
31MP0002132_abnormal_respiratory_system1.87699705
32MP0000350_abnormal_cell_proliferation1.86471326
33MP0006054_spinal_hemorrhage1.85817834
34MP0005397_hematopoietic_system_phenotyp1.80857780
35MP0001545_abnormal_hematopoietic_system1.80857780
36MP0003828_pulmonary_edema1.79141468
37MP0001835_abnormal_antigen_presentation1.72359152
38MP0004381_abnormal_hair_follicle1.72300865
39MP0002210_abnormal_sex_determination1.65259969
40MP0003172_abnormal_lysosome_physiology1.61126028
41MP0004883_abnormal_blood_vessel1.60978957
42MP0009764_decreased_sensitivity_to1.57250854
43MP0004947_skin_inflammation1.56736476
44MP0001845_abnormal_inflammatory_respons1.53226340
45MP0000465_gastrointestinal_hemorrhage1.51640117
46MP0003718_maternal_effect1.51103146
47MP0000569_abnormal_digit_pigmentation1.50684199
48MP0009278_abnormal_bone_marrow1.49408388
49MP0003123_paternal_imprinting1.48803051
50MP0001697_abnormal_embryo_size1.48019094
51MP0008932_abnormal_embryonic_tissue1.47914599
52MP0005380_embryogenesis_phenotype1.47645771
53MP0001672_abnormal_embryogenesis/_devel1.47645771
54MP0002009_preneoplasia1.47245461
55MP0003698_abnormal_male_reproductive1.45719342
56MP0002398_abnormal_bone_marrow1.44498787
57MP0010155_abnormal_intestine_physiology1.44367947
58MP0002019_abnormal_tumor_incidence1.42495513
59MP0003191_abnormal_cellular_cholesterol1.40703486
60MP0002877_abnormal_melanocyte_morpholog1.39852083
61MP0000490_abnormal_crypts_of1.39379164
62MP0003984_embryonic_growth_retardation1.37688512
63MP0001533_abnormal_skeleton_physiology1.37455763
64MP0000653_abnormal_sex_gland1.36080227
65MP0003787_abnormal_imprinting1.35913098
66MP0005076_abnormal_cell_differentiation1.34109953
67MP0003866_abnormal_defecation1.32945045
68MP0009697_abnormal_copulation1.32630653
69MP0001145_abnormal_male_reproductive1.32190549
70MP0002088_abnormal_embryonic_growth/wei1.31896632
71MP0000313_abnormal_cell_death1.30942644
72MP0005075_abnormal_melanosome_morpholog1.27687446
73MP0003121_genomic_imprinting1.26741444
74MP0005671_abnormal_response_to1.25724063
75MP0002086_abnormal_extraembryonic_tissu1.22889466
76MP0002080_prenatal_lethality1.20989498
77MP0000015_abnormal_ear_pigmentation1.19570383
78MP0008469_abnormal_protein_level1.18100060
79MP0005164_abnormal_response_to1.18035521
80MP0003763_abnormal_thymus_physiology1.17887365
81MP0000689_abnormal_spleen_morphology1.15885715
82MP0002332_abnormal_exercise_endurance1.12681868
83MP0002722_abnormal_immune_system1.11017479
84MP0002161_abnormal_fertility/fecundity1.10916732
85MP0001800_abnormal_humoral_immune1.09829566
86MP0001119_abnormal_female_reproductive1.09761067
87MP0000685_abnormal_immune_system1.09076061
88MP0001915_intracranial_hemorrhage1.07823297
89MP0002084_abnormal_developmental_patter1.07639651
90MP0001851_eye_inflammation1.06703303
91MP0000703_abnormal_thymus_morphology1.06541656
92MP0003221_abnormal_cardiomyocyte_apopto1.04588621
93MP0004484_altered_response_of1.03418100
94MP0009785_altered_susceptibility_to1.02447879
95MP0009333_abnormal_splenocyte_physiolog1.00482426
96MP0002429_abnormal_blood_cell1.00226367
97MP0003786_premature_aging0.99616039
98MP0005310_abnormal_salivary_gland0.98788328
99MP0002085_abnormal_embryonic_tissue0.97215722
100MP0005174_abnormal_tail_pigmentation0.94397456
101MP0000858_altered_metastatic_potential0.94124942
102MP0002452_abnormal_antigen_presenting0.93219062
103MP0000749_muscle_degeneration0.93100388
104MP0003699_abnormal_female_reproductive0.92774855
105MP0000716_abnormal_immune_system0.92408999
106MP0003045_fibrosis0.92125613
107MP0004197_abnormal_fetal_growth/weight/0.91217987
108MP0003183_abnormal_peptide_metabolism0.91120141
109MP0004264_abnormal_extraembryonic_tissu0.90636506
110MP0002277_abnormal_respiratory_mucosa0.89489016
111MP0002405_respiratory_system_inflammati0.89469083
112MP0002998_abnormal_bone_remodeling0.88006389
113MP0001853_heart_inflammation0.87926226
114MP0002269_muscular_atrophy0.87748885
115MP0005451_abnormal_body_composition0.86819954
116MP0003690_abnormal_glial_cell0.85238092
117MP0005621_abnormal_cell_physiology0.84723745
118MP0002420_abnormal_adaptive_immunity0.84215176
119MP0001819_abnormal_immune_cell0.83640220
120MP0004130_abnormal_muscle_cell0.83227969
121MP0000358_abnormal_cell_content/0.82069770
122MP0009763_increased_sensitivity_to0.81855120
123MP0005384_cellular_phenotype0.81837770
124MP0002723_abnormal_immune_serum0.81460550
125MP0006036_abnormal_mitochondrial_physio0.81338817
126MP0004084_abnormal_cardiac_muscle0.80491502
127MP0003186_abnormal_redox_activity0.80062066
128MP0003943_abnormal_hepatobiliary_system0.77948759
129MP0003567_abnormal_fetal_cardiomyocyte0.77583519
130MP0004233_abnormal_muscle_weight0.76862288
131MP0005376_homeostasis/metabolism_phenot0.74473293
132MP0009765_abnormal_xenobiotic_induced0.73708364
133MP0003890_abnormal_embryonic-extraembry0.73437331
134MP0002006_tumorigenesis0.72157656
135MP0008775_abnormal_heart_ventricle0.72136878
136MP0005464_abnormal_platelet_physiology0.70732187
137MP0000371_diluted_coat_color0.70464722
138MP0003252_abnormal_bile_duct0.70354786
139MP0002653_abnormal_ependyma_morphology0.69566699
140MP0004036_abnormal_muscle_relaxation0.68623028
141MP0002138_abnormal_hepatobiliary_system0.67833007
142MP0002928_abnormal_bile_duct0.67825216
143MP0001873_stomach_inflammation0.66940540
144MP0005000_abnormal_immune_tolerance0.65979947
145MP0005266_abnormal_metabolism0.65644278
146MP0002106_abnormal_muscle_physiology0.65193830
147MP0000249_abnormal_blood_vessel0.64243863
148MP0003448_altered_tumor_morphology0.63616658
149MP0005025_abnormal_response_to0.62829611
150MP0003566_abnormal_cell_adhesion0.62799714
151MP0005083_abnormal_biliary_tract0.61288043
152MP0003075_altered_response_to0.60124199
153MP0005166_decreased_susceptibility_to0.59062103
154MP0001663_abnormal_digestive_system0.57071282
155MP0008995_early_reproductive_senescence0.56936113
156MP0008004_abnormal_stomach_pH0.55527981
157MP0000604_amyloidosis0.53465172
158MP0000609_abnormal_liver_physiology0.53270438
159MP0009115_abnormal_fat_cell0.51226118

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.11682548
2Eczematoid dermatitis (HP:0000976)5.07858243
3T lymphocytopenia (HP:0005403)5.05807222
4Abnormality of T cell number (HP:0011839)4.77921696
5Recurrent fungal infections (HP:0002841)4.49096813
6Stomatitis (HP:0010280)4.39862734
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.24851455
8Gastrointestinal infarctions (HP:0005244)4.19412497
9Abnormality of the heme biosynthetic pathway (HP:0010472)4.16206062
10Elevated erythrocyte sedimentation rate (HP:0003565)4.10259783
11Chromsome breakage (HP:0040012)4.03588020
12Keratoconjunctivitis sicca (HP:0001097)3.93592873
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.89536067
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.75963056
15Recurrent skin infections (HP:0001581)3.74708395
16Meningitis (HP:0001287)3.71140272
17Recurrent gram-negative bacterial infections (HP:0005420)3.64423025
18Panhypogammaglobulinemia (HP:0003139)3.64384065
19Chronic mucocutaneous candidiasis (HP:0002728)3.57389068
20Recurrent cutaneous fungal infections (HP:0011370)3.57389068
21Papillary thyroid carcinoma (HP:0002895)3.56147725
22Abnormality of T cells (HP:0002843)3.54769817
23Abnormality of macrophages (HP:0004311)3.54589695
24Encephalitis (HP:0002383)3.50367263
25Agnosia (HP:0010524)3.47541169
26Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47317178
27Acute myeloid leukemia (HP:0004808)3.43288118
28Spontaneous hematomas (HP:0007420)3.37553996
29Mediastinal lymphadenopathy (HP:0100721)3.35352594
30Leukocytosis (HP:0001974)3.32228024
31Abnormality of chromosome stability (HP:0003220)3.31020711
32Volvulus (HP:0002580)3.26241733
33Eosinophilia (HP:0001880)3.18070913
34Vasculitis (HP:0002633)3.16220833
35Obstructive lung disease (HP:0006536)3.15388418
36Chronic obstructive pulmonary disease (HP:0006510)3.15388418
37Chest pain (HP:0100749)3.13445797
38Gingivitis (HP:0000230)3.12418473
39Granulocytopenia (HP:0001913)3.12096965
40Hemoptysis (HP:0002105)3.06979282
41Absent/shortened dynein arms (HP:0200106)3.05774180
42Dynein arm defect of respiratory motile cilia (HP:0012255)3.05774180
43Degeneration of anterior horn cells (HP:0002398)2.99785127
44Abnormality of the anterior horn cell (HP:0006802)2.99785127
45Abnormality of the fingertips (HP:0001211)2.98497857
46Myelodysplasia (HP:0002863)2.97913634
47Prolonged bleeding time (HP:0003010)2.95561399
48Amaurosis fugax (HP:0100576)2.94860852
49Thyroiditis (HP:0100646)2.92447099
50Gingival bleeding (HP:0000225)2.89494010
51Abnormality of B cell number (HP:0010975)2.88818638
52Male infertility (HP:0003251)2.88279060
53Pulmonary infiltrates (HP:0002113)2.86123064
54Abnormal spermatogenesis (HP:0008669)2.84230029
55Severe combined immunodeficiency (HP:0004430)2.83846085
56Autoimmune hemolytic anemia (HP:0001890)2.76730002
57Abnormality of eosinophils (HP:0001879)2.75399173
58Urticaria (HP:0001025)2.73630737
59Epistaxis (HP:0000421)2.64008409
60Hypoplasia of the thymus (HP:0000778)2.63275406
61Sloping forehead (HP:0000340)2.62215598
62Impulsivity (HP:0100710)2.62084345
63Abnormality of T cell physiology (HP:0011840)2.61074536
64Poikilocytosis (HP:0004447)2.60759397
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.59894735
66Chronic bronchitis (HP:0004469)2.59836012
67B lymphocytopenia (HP:0010976)2.58977480
68Anorexia (HP:0002039)2.57644210
69Hypochromic microcytic anemia (HP:0004840)2.57620128
70Microcytic anemia (HP:0001935)2.55747334
71Thrombocytosis (HP:0001894)2.50658078
72Cellulitis (HP:0100658)2.50438735
73Pulmonary embolism (HP:0002204)2.50146594
74Gangrene (HP:0100758)2.49874816
75Medulloblastoma (HP:0002885)2.48143196
76Ectopic kidney (HP:0000086)2.47542113
77Cortical dysplasia (HP:0002539)2.46007903
78Osteomyelitis (HP:0002754)2.43862535
79Abnormality of the preputium (HP:0100587)2.43744033
80Thyroid carcinoma (HP:0002890)2.43515919
81Hypochromic anemia (HP:0001931)2.41894218
82Prostate neoplasm (HP:0100787)2.40857159
83Pustule (HP:0200039)2.39504403
84Inflammation of the large intestine (HP:0002037)2.38405092
85Neoplasm of the tracheobronchial system (HP:0100552)2.36916089
86Peritonitis (HP:0002586)2.33911277
87Aplastic anemia (HP:0001915)2.33588976
88Optic neuritis (HP:0100653)2.33209905
89Retrobulbar optic neuritis (HP:0100654)2.33209905
90Cutaneous melanoma (HP:0012056)2.31295930
91Acute hepatic failure (HP:0006554)2.31275361
92Autoimmune thrombocytopenia (HP:0001973)2.27919180
93Nasal polyposis (HP:0100582)2.27914511
94Abnormality of lateral ventricle (HP:0030047)2.26956080
95Patellar aplasia (HP:0006443)2.25780660
96Duodenal stenosis (HP:0100867)2.25658076
97Small intestinal stenosis (HP:0012848)2.25658076
98Infertility (HP:0000789)2.25256304
99Combined immunodeficiency (HP:0005387)2.25199374
100IgG deficiency (HP:0004315)2.24711963
101Slow saccadic eye movements (HP:0000514)2.24364947
102Viral hepatitis (HP:0006562)2.23350681
103High pitched voice (HP:0001620)2.21072427
104Episodic fever (HP:0001954)2.20771450
105Bronchitis (HP:0012387)2.20629947
106Stomach cancer (HP:0012126)2.20419419
107Rhinitis (HP:0012384)2.20148761
108Exercise-induced muscle cramps (HP:0003710)2.19308930
109Breast hypoplasia (HP:0003187)2.18215600
110Sepsis (HP:0100806)2.17734242
111Agammaglobulinemia (HP:0004432)2.15951092
112Chronic diarrhea (HP:0002028)2.14738320
113Sandal gap (HP:0001852)2.14393029
114Colitis (HP:0002583)2.14287719
115Alveolar cell carcinoma (HP:0006519)2.14113251
116Gastrointestinal inflammation (HP:0004386)2.14102542
117Subacute progressive viral hepatitis (HP:0006572)2.14094699
118Abnormal respiratory motile cilium physiology (HP:0012261)2.14075188
119Cafe-au-lait spot (HP:0000957)2.12211109
120Deep philtrum (HP:0002002)2.12020030
121Absent frontal sinuses (HP:0002688)2.11692399
122Keratitis (HP:0000491)2.11674519
123Type 2 muscle fiber atrophy (HP:0003554)2.11308383
124Meckel diverticulum (HP:0002245)2.09153828
125Increased IgE level (HP:0003212)2.07887801
126Abnormality of the pleura (HP:0002103)2.07199691
127Hypoplasia of the capital femoral epiphysis (HP:0003090)2.04639780
128Hematochezia (HP:0002573)2.04415971
129Hypoproteinemia (HP:0003075)2.01515501
130Abnormal respiratory epithelium morphology (HP:0012253)2.00953099
131Abnormal respiratory motile cilium morphology (HP:0005938)2.00953099
132Biliary tract neoplasm (HP:0100574)2.00936932
133Fatigue (HP:0012378)1.99228971
134Abnormality of the endocardium (HP:0004306)1.98601132
135Vertigo (HP:0002321)1.97106619
136Abnormality of the ileum (HP:0001549)1.96771699
137Pulmonary fibrosis (HP:0002206)1.96145774
138IgM deficiency (HP:0002850)1.95588749
139Recurrent bronchitis (HP:0002837)1.94492571
140Aplasia/Hypoplasia of the thymus (HP:0010515)1.93633599
141Azoospermia (HP:0000027)1.92612316
142Aplasia/Hypoplasia of the patella (HP:0006498)1.92326810
143Prominent nose (HP:0000448)1.91064546
144Abnormality of the peritoneum (HP:0002585)1.90530348
145Polycythemia (HP:0001901)1.90137934
146Muscle fiber inclusion bodies (HP:0100299)1.90087082
147Thrombophlebitis (HP:0004418)1.89697918
148Ulnar deviation of the wrist (HP:0003049)1.89280400
149Rhabdomyosarcoma (HP:0002859)1.88528597
150Abnormality of the nasal mucosa (HP:0000433)1.88496599
151Acanthocytosis (HP:0001927)1.88403575
152Myositis (HP:0100614)1.86584823
153Long eyelashes (HP:0000527)1.84298735
154Polyneuropathy (HP:0001271)1.84142219
155Neoplasm of the oral cavity (HP:0100649)1.83597803
156Hypoplasia of the pons (HP:0012110)1.83299509
157Nephronophthisis (HP:0000090)1.82509362
158Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.82049758
159Keratoconjunctivitis (HP:0001096)1.80947853
160Basal cell carcinoma (HP:0002671)1.80863024
161Abnormality of the prostate (HP:0008775)1.80392093
162Muscle fiber atrophy (HP:0100295)1.79480437
163Nephroblastoma (Wilms tumor) (HP:0002667)1.77468087
164Truncal obesity (HP:0001956)1.76599456
165Recurrent viral infections (HP:0004429)1.76569291
166Abnormality of the pons (HP:0007361)1.74038376
167Orchitis (HP:0100796)1.73992442
168Embryonal renal neoplasm (HP:0011794)1.73813849
169Disinhibition (HP:0000734)1.72087388
170Bronchiectasis (HP:0002110)1.71785555
171Nemaline bodies (HP:0003798)1.70529855
172Recurrent bacterial skin infections (HP:0005406)1.70425071
173Arterial thrombosis (HP:0004420)1.69745047
174Short middle phalanx of the 5th finger (HP:0004220)1.69217161
175Abnormality of the calcaneus (HP:0008364)1.68960512
176Tongue fasciculations (HP:0001308)1.68844260
177Clubbing of toes (HP:0100760)1.67822518
178Colon cancer (HP:0003003)1.65909544
179Pancreatic fibrosis (HP:0100732)1.65107370
180Recurrent abscess formation (HP:0002722)1.65057004
181Bone marrow hypocellularity (HP:0005528)1.64715719
182Neoplasm of the colon (HP:0100273)1.64635222

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.72538280
2RIPK44.35600185
3PLK43.69293359
4PDK43.38598413
5PDK33.38598413
6BLK3.26293242
7EEF2K3.12336933
8NEK23.02234785
9EIF2AK12.58819816
10IRAK42.52856467
11TTK2.43566834
12FES2.27267806
13BUB12.24204059
14WEE12.21975029
15CSK2.20360928
16NEK12.15806549
17LATS12.06951295
18STK38L2.06036836
19GRK62.04923638
20BTK2.02759123
21SYK2.02291428
22PIK3CG2.00361471
23BMPR21.97672532
24BRSK21.93601813
25ACVR1B1.81992069
26PDK21.71606482
27STK31.70764434
28STK101.65416213
29PLK11.63688407
30CDK121.63597456
31ZAP701.62899231
32JAK21.56263299
33HCK1.54765852
34ITK1.54440842
35MAPKAPK31.51639852
36ATR1.49183796
37FGR1.49058001
38IRAK11.47374825
39PLK31.44592730
40LYN1.41807047
41PRPF4B1.41581485
42TRPM71.40642079
43JAK31.40548411
44ZAK1.38650763
45CHEK21.37415765
46MAP3K21.37319299
47AURKB1.36148282
48RPS6KB21.34757679
49TSSK61.33635500
50CAMKK21.29870058
51MAP3K61.29836588
52BRSK11.27235657
53BRAF1.26715023
54CCNB11.26714947
55TNK21.25091728
56MAP3K131.23683349
57SRPK11.21407639
58ERBB41.19441422
59CHEK11.19239027
60VRK11.18157075
61STK241.17767875
62LCK1.16405131
63FLT31.13767297
64YES11.13371846
65TYK21.12726440
66MAP3K81.12364086
67EIF2AK31.10934789
68PASK1.08092043
69MATK1.07377736
70MAP3K11.05285963
71TBK11.04430161
72STK41.04184844
73PIM11.02171691
74KSR21.01863784
75* ATM1.00788113
76WNK11.00781555
77TAOK11.00763426
78TAOK30.97227325
79TGFBR10.95173433
80TTN0.94971374
81MAP3K30.94877783
82NLK0.93930130
83IRAK20.91097670
84PTK2B0.89634023
85CDK40.88987002
86MKNK10.87712546
87RPS6KA40.83569146
88EPHB10.82999743
89SGK30.79995795
90MELK0.78828817
91CDK80.77954128
92MAP3K50.76909045
93TESK10.76678511
94SCYL20.75395576
95OBSCN0.74906502
96RAF10.73366805
97NEK90.73072688
98MAP2K30.72952455
99MAP3K140.71831876
100KSR10.70665998
101TGFBR20.69765168
102PDK10.68587433
103LATS20.68120942
104AKT30.66629156
105RPS6KB10.66609160
106TEC0.65174466
107KIT0.63456372
108AURKA0.63167506
109CHUK0.62243825
110BRD40.61606388
111CDK20.61332334
112MAPK110.61221708
113PRKCQ0.59597821
114CLK10.59563974
115MAP2K40.58345046
116GRK70.56830073
117MUSK0.56525944
118FRK0.55935860
119SIK30.55636576
120NUAK10.55465590
121CDK60.55320503
122MAP3K70.54647724
123MARK20.54582249
124STK110.53885729
125CDK70.53562165
126EPHA30.51566764
127DYRK30.49593361
128PKN20.49388783
129TXK0.48962607
130MAPK120.48902148
131EIF2AK20.48032792
132CDK10.47630963
133MAP2K60.47164658
134DYRK1A0.46414415
135ERBB30.45759195
136PRKAA10.44088253
137SGK10.43718760
138PRKAA20.42784811
139CDK90.42325611
140MAP4K10.41587768
141NEK60.40854933
142GRK50.40690900
143PLK20.40173858
144CAMK40.40044748
145SGK20.39498331
146RET0.38949492
147MAPK70.38789176
148FYN0.38119138
149FGFR30.36997941
150CAMK1D0.36812945
151EGFR0.36056605
152CSF1R0.35564116
153HIPK20.35449815
154IKBKE0.34428063
155LRRK20.34344253
156IKBKB0.34180400
157MAP3K110.32317617
158RPS6KA50.31750839
159ERBB20.30686057
160MKNK20.27506848
161PRKD30.26041828
162JAK10.25568639
163CSNK2A10.25522029
164MARK30.25065746

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.96918054
2Cell cycle_Homo sapiens_hsa041103.40578260
3Mismatch repair_Homo sapiens_hsa034303.40535897
4RNA transport_Homo sapiens_hsa030133.01748348
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.87605736
6Homologous recombination_Homo sapiens_hsa034402.78732487
7Base excision repair_Homo sapiens_hsa034102.68257309
8Basal transcription factors_Homo sapiens_hsa030222.56685439
9RNA degradation_Homo sapiens_hsa030182.49669746
10Non-homologous end-joining_Homo sapiens_hsa034502.45894465
11Staphylococcus aureus infection_Homo sapiens_hsa051502.36808697
12Nucleotide excision repair_Homo sapiens_hsa034202.36759276
13Fanconi anemia pathway_Homo sapiens_hsa034602.29117194
14Autoimmune thyroid disease_Homo sapiens_hsa053202.14057824
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98557084
16Spliceosome_Homo sapiens_hsa030401.92708010
17p53 signaling pathway_Homo sapiens_hsa041151.92059120
18RNA polymerase_Homo sapiens_hsa030201.89130028
19T cell receptor signaling pathway_Homo sapiens_hsa046601.83974112
20One carbon pool by folate_Homo sapiens_hsa006701.81299175
21Pyrimidine metabolism_Homo sapiens_hsa002401.81212888
22mRNA surveillance pathway_Homo sapiens_hsa030151.76295837
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69110646
24Proteasome_Homo sapiens_hsa030501.63965895
25Asthma_Homo sapiens_hsa053101.63795541
26Systemic lupus erythematosus_Homo sapiens_hsa053221.61205273
27Herpes simplex infection_Homo sapiens_hsa051681.57784215
28Vitamin B6 metabolism_Homo sapiens_hsa007501.56060526
29Antigen processing and presentation_Homo sapiens_hsa046121.48955838
30Chemokine signaling pathway_Homo sapiens_hsa040621.44931939
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41767117
32Oocyte meiosis_Homo sapiens_hsa041141.37721528
33Epstein-Barr virus infection_Homo sapiens_hsa051691.34546303
34Viral carcinogenesis_Homo sapiens_hsa052031.31833887
35Platelet activation_Homo sapiens_hsa046111.31761122
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29517705
37Legionellosis_Homo sapiens_hsa051341.26883940
38Dorso-ventral axis formation_Homo sapiens_hsa043201.26177058
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23306566
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21165587
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20970533
42Purine metabolism_Homo sapiens_hsa002301.18585455
43Measles_Homo sapiens_hsa051621.17992436
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.13248202
45Hepatitis C_Homo sapiens_hsa051601.08121691
46Influenza A_Homo sapiens_hsa051641.06461965
47African trypanosomiasis_Homo sapiens_hsa051431.03158732
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02341535
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.99662382
50Pentose phosphate pathway_Homo sapiens_hsa000300.99487833
51Phagosome_Homo sapiens_hsa041450.98019454
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95654638
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94871363
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94480502
55Allograft rejection_Homo sapiens_hsa053300.93171339
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91444452
57Hepatitis B_Homo sapiens_hsa051610.88401235
58Leishmaniasis_Homo sapiens_hsa051400.88139087
59Rheumatoid arthritis_Homo sapiens_hsa053230.88097883
60Selenocompound metabolism_Homo sapiens_hsa004500.87434534
61Renal cell carcinoma_Homo sapiens_hsa052110.86314423
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.85650336
63Viral myocarditis_Homo sapiens_hsa054160.84873996
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83628586
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82041015
66Apoptosis_Homo sapiens_hsa042100.81632921
67Small cell lung cancer_Homo sapiens_hsa052220.79975959
68Pyruvate metabolism_Homo sapiens_hsa006200.79755766
69Inositol phosphate metabolism_Homo sapiens_hsa005620.79645400
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79459653
71HTLV-I infection_Homo sapiens_hsa051660.78823063
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78323066
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78299944
74Regulation of autophagy_Homo sapiens_hsa041400.77628702
75Biosynthesis of amino acids_Homo sapiens_hsa012300.77011394
76Pertussis_Homo sapiens_hsa051330.76982354
77Toxoplasmosis_Homo sapiens_hsa051450.76366219
78VEGF signaling pathway_Homo sapiens_hsa043700.76195872
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.75984975
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.75733110
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72045513
82Primary immunodeficiency_Homo sapiens_hsa053400.71638168
83Pancreatic cancer_Homo sapiens_hsa052120.71181702
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.71152127
85MicroRNAs in cancer_Homo sapiens_hsa052060.70955961
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69929951
87Thyroid cancer_Homo sapiens_hsa052160.69832980
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.67666823
89Shigellosis_Homo sapiens_hsa051310.66664535
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.65537990
91Type II diabetes mellitus_Homo sapiens_hsa049300.64218727
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62610413
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62061350
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60718717
95Glucagon signaling pathway_Homo sapiens_hsa049220.59664356
96Type I diabetes mellitus_Homo sapiens_hsa049400.59268556
97Insulin resistance_Homo sapiens_hsa049310.58488847
98Choline metabolism in cancer_Homo sapiens_hsa052310.58381987
99Hematopoietic cell lineage_Homo sapiens_hsa046400.56165664
100Carbon metabolism_Homo sapiens_hsa012000.55063001
101TNF signaling pathway_Homo sapiens_hsa046680.53088098
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52791772
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52281065
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51928599
105Chronic myeloid leukemia_Homo sapiens_hsa052200.51858394
106Colorectal cancer_Homo sapiens_hsa052100.51074272
107FoxO signaling pathway_Homo sapiens_hsa040680.50878734
108mTOR signaling pathway_Homo sapiens_hsa041500.50232367
109Salmonella infection_Homo sapiens_hsa051320.49631191
110Circadian rhythm_Homo sapiens_hsa047100.48825719
111Prolactin signaling pathway_Homo sapiens_hsa049170.48601401
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48510288
113Adherens junction_Homo sapiens_hsa045200.48056797
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47046570
115TGF-beta signaling pathway_Homo sapiens_hsa043500.46655982
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.46168714
117B cell receptor signaling pathway_Homo sapiens_hsa046620.45535428
118GnRH signaling pathway_Homo sapiens_hsa049120.45500374
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44517943
120MAPK signaling pathway_Homo sapiens_hsa040100.43448992
121Graft-versus-host disease_Homo sapiens_hsa053320.43387054
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42684978
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42610982
124ErbB signaling pathway_Homo sapiens_hsa040120.42426662
125Glioma_Homo sapiens_hsa052140.42223372
126HIF-1 signaling pathway_Homo sapiens_hsa040660.42195232
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40054085
128Alcoholism_Homo sapiens_hsa050340.38701609
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38304215
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.37537362
131Osteoclast differentiation_Homo sapiens_hsa043800.36477073
132Caffeine metabolism_Homo sapiens_hsa002320.34902853
133Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34016632
134Tuberculosis_Homo sapiens_hsa051520.33636440
135Malaria_Homo sapiens_hsa051440.33282244
136AMPK signaling pathway_Homo sapiens_hsa041520.31526840
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30998257
138ABC transporters_Homo sapiens_hsa020100.30674200
139Endocytosis_Homo sapiens_hsa041440.30308217
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.30275024
141Long-term potentiation_Homo sapiens_hsa047200.29985912
142Prostate cancer_Homo sapiens_hsa052150.29148362
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27670775
144Endometrial cancer_Homo sapiens_hsa052130.27539798
1452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27241236
146Acute myeloid leukemia_Homo sapiens_hsa052210.26565150
147Non-small cell lung cancer_Homo sapiens_hsa052230.24347394
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23614608
149Linoleic acid metabolism_Homo sapiens_hsa005910.22480180

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