ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular response to epidermal growth factor stimulus (GO:0071364)	8.62805300
2	O-glycan processing (GO:0016266)	8.36971013
3	regulation of ARF GTPase activity (GO:0032312)	7.18314946
4	response to epidermal growth factor (GO:0070849)	6.81867865
5	establishment of protein localization to Golgi (GO:0072600)	5.88491718
6	nephron tubule morphogenesis (GO:0072078)	5.81612448
7	nephron epithelium morphogenesis (GO:0072088)	5.81612448
8	protein O-linked glycosylation (GO:0006493)	5.69356386
9	C21-steroid hormone biosynthetic process (GO:0006700)	5.68900056
10	protein targeting to Golgi (GO:0000042)	5.63479418
11	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.40736234
12	negative regulation of digestive system process (GO:0060457)	5.39576251
13	trivalent inorganic anion homeostasis (GO:0072506)	5.07622138
14	phosphate ion homeostasis (GO:0055062)	5.07622138
15	glucocorticoid biosynthetic process (GO:0006704)	4.88877439
16	cellular response to glucocorticoid stimulus (GO:0071385)	4.81326537
17	cellular anion homeostasis (GO:0030002)	4.68376067
18	L-fucose catabolic process (GO:0042355)	4.66167087
19	fucose catabolic process (GO:0019317)	4.66167087
20	L-fucose metabolic process (GO:0042354)	4.66167087
21	striated muscle atrophy (GO:0014891)	4.54786052
22	renal tubule morphogenesis (GO:0061333)	4.49644424
23	cellular response to corticosteroid stimulus (GO:0071384)	4.45353998
24	phosphate ion transmembrane transport (GO:0035435)	4.43990654
25	protein localization to Golgi apparatus (GO:0034067)	4.34937235
26	membrane depolarization during action potential (GO:0086010)	4.29784722
27	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	4.28558449
28	digestive system process (GO:0022600)	4.27030732
29	cilium or flagellum-dependent cell motility (GO:0001539)	4.26675732
30	vocalization behavior (GO:0071625)	4.24982407
31	actin filament capping (GO:0051693)	4.24592841
32	regulation of acrosome reaction (GO:0060046)	4.22385844
33	auditory receptor cell stereocilium organization (GO:0060088)	4.21788426
34	skeletal muscle adaptation (GO:0043501)	4.16533189
35	muscle atrophy (GO:0014889)	4.03276079
36	renal absorption (GO:0070293)	3.98973995
37	fucosylation (GO:0036065)	3.84895049
38	phosphate ion transport (GO:0006817)	3.82552605
39	creatine metabolic process (GO:0006600)	3.73187822
40	negative regulation of actin filament depolymerization (GO:0030835)	3.61512102
41	myoblast fusion (GO:0007520)	3.60392256
42	photoreceptor cell maintenance (GO:0045494)	3.55554539
43	regulation of RIG-I signaling pathway (GO:0039535)	3.50191399
44	inner ear receptor cell differentiation (GO:0060113)	3.49788640
45	hair cell differentiation (GO:0035315)	3.46872023
46	dendritic spine morphogenesis (GO:0060997)	3.39761253
47	calcium ion import (GO:0070509)	3.36541519
48	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.34705435
49	syncytium formation (GO:0006949)	3.34545207
50	syncytium formation by plasma membrane fusion (GO:0000768)	3.23843917
51	cellular response to retinoic acid (GO:0071300)	3.21238923
52	regulation of cholesterol homeostasis (GO:2000188)	3.13772086
53	growth hormone secretion (GO:0030252)	3.11170668
54	dendritic spine organization (GO:0097061)	3.10081051
55	establishment of skin barrier (GO:0061436)	3.08748720
56	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.98456812
57	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.94956507
58	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.92478900
59	actin nucleation (GO:0045010)	2.90658212
60	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.90079906
61	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	2.89431422
62	auditory receptor cell differentiation (GO:0042491)	2.88673572
63	collecting duct development (GO:0072044)	2.82785569
64	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.81364962
65	inner ear receptor stereocilium organization (GO:0060122)	2.81066922
66	multicellular organismal water homeostasis (GO:0050891)	2.80258445
67	regulation of water loss via skin (GO:0033561)	2.77467918
68	extracellular fibril organization (GO:0043206)	2.71566283
69	detection of mechanical stimulus (GO:0050982)	2.71096252
70	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.69448502
71	histone H3-K9 demethylation (GO:0033169)	2.68778570
72	inositol metabolic process (GO:0006020)	2.67814688
73	neural tube development (GO:0021915)	2.67495440
74	epithelial cell fate commitment (GO:0072148)	2.67392199
75	mechanoreceptor differentiation (GO:0042490)	2.67308710
76	bone trabecula formation (GO:0060346)	2.64784948
77	negative regulation of myotube differentiation (GO:0010832)	2.64290143
78	regulation of hippo signaling (GO:0035330)	2.63299375
79	regulation of podosome assembly (GO:0071801)	2.60824198
80	glucocorticoid metabolic process (GO:0008211)	2.59736421
81	osteoblast development (GO:0002076)	2.58220939
82	C21-steroid hormone metabolic process (GO:0008207)	2.55973558
83	positive regulation of digestive system process (GO:0060456)	2.54886634
84	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.53370478
85	lipoprotein metabolic process (GO:0042157)	2.53010868
86	striated muscle adaptation (GO:0014888)	2.52444712
87	macroautophagy (GO:0016236)	2.51168669
88	metanephric nephron tubule development (GO:0072234)	2.50876895
89	metanephric tubule development (GO:0072170)	2.50876895
90	glomerular basement membrane development (GO:0032836)	2.49743271
91	regulation of digestive system process (GO:0044058)	2.48478993
92	regulation of actin filament depolymerization (GO:0030834)	2.47444429
93	phospholipid scrambling (GO:0017121)	2.45870710
94	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	2.43806945
95	GDP-mannose metabolic process (GO:0019673)	2.42705440
96	water homeostasis (GO:0030104)	2.42170076
97	maintenance of gastrointestinal epithelium (GO:0030277)	15.1593097
98	regulation of G0 to G1 transition (GO:0070316)	14.3662871
99	epithelial structure maintenance (GO:0010669)	11.2034580
100	response to vitamin A (GO:0033189)	10.0348943

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	6.21808763
2	DROSHA_22980978_ChIP-Seq_HELA_Human	5.26842716
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.56667427
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.32188499
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.07601878
6	WDR5_24793694_ChIP-Seq_LNCAP_Human	2.56715585
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.53322976
8	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.42468272
9	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.22825852
10	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.20472924
11	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.20427259
12	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.14168116
13	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.91080295
14	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.89417766
15	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.84813822
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.77745950
17	AR_21572438_ChIP-Seq_LNCaP_Human	1.77737990
18	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.77541186
19	SMC4_20622854_ChIP-Seq_HELA_Human	1.69986621
20	BCAT_22108803_ChIP-Seq_LS180_Human	1.67667396
21	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.66165383
22	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.56328422
23	VDR_22108803_ChIP-Seq_LS180_Human	1.54196660
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.53845368
25	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.53456007
26	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.51745093
27	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.47522716
28	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.47424353
29	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.45626111
30	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.43816228
31	CTCF_27219007_Chip-Seq_Bcells_Human	1.39692510
32	NFYA_21822215_ChIP-Seq_K562_Human	1.38910176
33	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.36877918
34	KLF5_25053715_ChIP-Seq_YYC3_Human	1.35301613
35	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.33334324
36	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.33308398
37	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.31255583
38	AHR_22903824_ChIP-Seq_MCF-7_Human	1.30644260
39	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.29593036
40	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.29064521
41	STAT3_23295773_ChIP-Seq_U87_Human	1.27949732
42	E2F1_20622854_ChIP-Seq_HELA_Human	1.27275062
43	OCT4_20526341_ChIP-Seq_ESCs_Human	1.23154673
44	CDX2_22108803_ChIP-Seq_LS180_Human	1.22134808
45	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.20452661
46	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.19396737
47	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.16782440
48	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.16410196
49	CTCF_20526341_ChIP-Seq_ESCs_Human	1.16042420
50	BCL6_27268052_Chip-Seq_Bcells_Human	1.15764855
51	OCT4_19829295_ChIP-Seq_ESCs_Human	1.14353320
52	TCF4_23295773_ChIP-Seq_U87_Human	1.13078920
53	AR_19668381_ChIP-Seq_PC3_Human	1.12931563
54	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.10895512
55	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.10592680
56	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10100181
57	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.09713999
58	SPI1_23127762_ChIP-Seq_K562_Human	1.08949345
59	TBL1_22424771_ChIP-Seq_293T_Human	1.07676031
60	TP53_16413492_ChIP-PET_HCT116_Human	1.06662134
61	GATA6_25053715_ChIP-Seq_YYC3_Human	1.05854540
62	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.03185432
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.03006370
64	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.02020609
65	TP63_22573176_ChIP-Seq_HFKS_Human	1.01967120
66	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.00877288
67	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.00119419
68	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.98691836
69	P68_20966046_ChIP-Seq_HELA_Human	0.98187347
70	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98024790
71	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.97251924
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96794101
73	RACK7_27058665_Chip-Seq_MCF-7_Human	0.96775249
74	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.96606340
75	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.96030113
76	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.95960416
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95226569
78	MYC_19915707_ChIP-ChIP_AK7_Human	0.93893038
79	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.93756512
80	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.93295968
81	CBP_20019798_ChIP-Seq_JUKART_Human	0.93090264
82	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.93090264
83	NFYB_21822215_ChIP-Seq_K562_Human	0.92787113
84	ERA_21632823_ChIP-Seq_H3396_Human	0.92369903
85	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.92073263
86	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.90115452
87	BCOR_27268052_Chip-Seq_Bcells_Human	0.89987771
88	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.89916273
89	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.89183912
90	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.88998424
91	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.88597743
92	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.88493359
93	CBP_21632823_ChIP-Seq_H3396_Human	0.88395849
94	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.87776305
95	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.87614989
96	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.87258529
97	GATA4_25053715_ChIP-Seq_YYC3_Human	0.87057932
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.86801549
99	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.86105907
100	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.85832107

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000465_gastrointestinal_hemorrhage	5.60338318
2	MP0004043_abnormal_pH_regulation	5.37457806
3	MP0000579_abnormal_nail_morphology	5.10351827
4	MP0003879_abnormal_hair_cell	4.65724896
5	MP0003705_abnormal_hypodermis_morpholog	3.70968368
6	MP0005377_hearing/vestibular/ear_phenot	3.36096446
7	MP0003878_abnormal_ear_physiology	3.36096446
8	MP0002822_catalepsy	3.35100114
9	MP0003866_abnormal_defecation	3.30767467
10	MP0000566_synostosis	3.16271771
11	MP0005275_abnormal_skin_tensile	3.06264936
12	MP0008438_abnormal_cutaneous_collagen	2.96275244
13	MP0001666_abnormal_nutrient_absorption	2.77975688
14	MP0001485_abnormal_pinna_reflex	2.70722046
15	MP0008004_abnormal_stomach_pH	2.20186343
16	MP0001765_abnormal_ion_homeostasis	2.19524403
17	MP0001661_extended_life_span	2.14301236
18	MP0003091_abnormal_cell_migration	2.01600814
19	MP0003045_fibrosis	1.97951478
20	MP0001664_abnormal_digestion	1.97011480
21	MP0008057_abnormal_DNA_replication	1.85051351
22	MP0002138_abnormal_hepatobiliary_system	1.80067960
23	MP0004742_abnormal_vestibular_system	1.76624875
24	MP0000383_abnormal_hair_follicle	1.76227671
25	MP0003252_abnormal_bile_duct	1.72701033
26	MP0002060_abnormal_skin_morphology	1.66953511
27	MP0001663_abnormal_digestive_system	1.62737072
28	MP0005257_abnormal_intraocular_pressure	1.49365887
29	MP0005083_abnormal_biliary_tract	1.47543232
30	MP0010678_abnormal_skin_adnexa	1.46747651
31	MP0004019_abnormal_vitamin_homeostasis	1.46321304
32	MP0010234_abnormal_vibrissa_follicle	1.43820130
33	MP0005381_digestive/alimentary_phenotyp	1.40278222
34	MP0000026_abnormal_inner_ear	1.38817163
35	MP0003950_abnormal_plasma_membrane	1.38514347
36	MP0001963_abnormal_hearing_physiology	1.37005479
37	MP0000751_myopathy	1.34814754
38	MP0001243_abnormal_dermal_layer	1.34293479
39	MP0000749_muscle_degeneration	1.32357009
40	MP0003195_calcinosis	1.31968596
41	MP0000538_abnormal_urinary_bladder	1.31716972
42	MP0000427_abnormal_hair_cycle	1.28577481
43	MP0010155_abnormal_intestine_physiology	1.28097624
44	MP0003279_aneurysm	1.23411662
45	MP0002098_abnormal_vibrissa_morphology	1.19348777
46	MP0005551_abnormal_eye_electrophysiolog	1.19144367
47	MP0002249_abnormal_larynx_morphology	1.13064016
48	MP0002896_abnormal_bone_mineralization	1.11877575
49	MP0001501_abnormal_sleep_pattern	1.03325860
50	MP0002229_neurodegeneration	1.02676604
51	MP0009046_muscle_twitch	1.02130512
52	MP0000647_abnormal_sebaceous_gland	0.99395171
53	MP0010030_abnormal_orbit_morphology	0.99348262
54	MP0008995_early_reproductive_senescence	0.99229504
55	MP0001958_emphysema	0.98008009
56	MP0002735_abnormal_chemical_nociception	0.97993196
57	MP0002928_abnormal_bile_duct	0.92534462
58	MP0000747_muscle_weakness	0.92363717
59	MP0002269_muscular_atrophy	0.89892656
60	MP0003283_abnormal_digestive_organ	0.86094814
61	MP0001348_abnormal_lacrimal_gland	0.85846199
62	MP0010386_abnormal_urinary_bladder	0.83253193
63	MP0001542_abnormal_bone_strength	0.82831801
64	MP0010771_integument_phenotype	0.77196666
65	MP0005310_abnormal_salivary_gland	0.74945743
66	MP0002168_other_aberrant_phenotype	0.73478726
67	MP0000371_diluted_coat_color	0.72813045
68	MP0002733_abnormal_thermal_nociception	0.71685188
69	MP0001502_abnormal_circadian_rhythm	0.71117321
70	MP0010094_abnormal_chromosome_stability	0.66871563
71	MP0004147_increased_porphyrin_level	0.66675944
72	MP0004145_abnormal_muscle_electrophysio	0.66352320
73	MP0002136_abnormal_kidney_physiology	0.65688106
74	MP0001849_ear_inflammation	0.64989432
75	MP0004264_abnormal_extraembryonic_tissu	0.63988833
76	MP0005076_abnormal_cell_differentiation	0.63502657
77	MP0001270_distended_abdomen	0.63023006
78	MP0003646_muscle_fatigue	0.61430180
79	MP0002272_abnormal_nervous_system	0.61392590
80	MP0000230_abnormal_systemic_arterial	0.60410055
81	MP0000470_abnormal_stomach_morphology	0.59504946
82	MP0005386_behavior/neurological_phenoty	0.57995701
83	MP0004924_abnormal_behavior	0.57995701
84	MP0002075_abnormal_coat/hair_pigmentati	0.56319793
85	MP0000477_abnormal_intestine_morphology	0.55689757
86	MP0002127_abnormal_cardiovascular_syste	0.54006013
87	MP0002067_abnormal_sensory_capabilities	0.53636641
88	MP0003786_premature_aging	0.52706156
89	MP0005670_abnormal_white_adipose	0.52238048
90	MP0004859_abnormal_synaptic_plasticity	0.51747121
91	MP0000432_abnormal_head_morphology	0.51593848
92	MP0003183_abnormal_peptide_metabolism	0.51295342
93	MP0002752_abnormal_somatic_nervous	0.50930186
94	MP0004036_abnormal_muscle_relaxation	0.50238360
95	MP0001756_abnormal_urination	0.49097994
96	MP0005501_abnormal_skin_physiology	0.47235531
97	MP0005508_abnormal_skeleton_morphology	0.46932415
98	MP0005266_abnormal_metabolism	0.46222496
99	MP0005636_abnormal_mineral_homeostasis	0.45953624
100	MP0003943_abnormal_hepatobiliary_system	0.44318926

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	6.15812662
2	Palpebral edema (HP:0100540)	5.61281185
3	Congenital sensorineural hearing impairment (HP:0008527)	5.34434826
4	Bilateral sensorineural hearing impairment (HP:0008619)	5.32736088
5	Abnormality of dentin (HP:0010299)	5.32417640
6	Thin bony cortex (HP:0002753)	5.01731613
7	Hyperkalemia (HP:0002153)	4.76565498
8	Enlarged epiphyses (HP:0010580)	4.67147876
9	Mask-like facies (HP:0000298)	4.63776964
10	Hypophosphatemic rickets (HP:0004912)	4.26638470
11	Hemorrhage of the eye (HP:0011885)	4.03414774
12	Abnormal hair laboratory examination (HP:0003328)	4.02578226
13	Abnormality of chloride homeostasis (HP:0011422)	3.84966452
14	Tibial bowing (HP:0002982)	3.78391257
15	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.75029302
16	Delayed epiphyseal ossification (HP:0002663)	3.72624470
17	Distal lower limb amyotrophy (HP:0008944)	3.68238811
18	Cerebral aneurysm (HP:0004944)	3.67285003
19	Upper limb amyotrophy (HP:0009129)	3.61568534
20	Distal upper limb amyotrophy (HP:0007149)	3.61568534
21	Duplicated collecting system (HP:0000081)	3.31656176
22	Urethral obstruction (HP:0000796)	3.30269712
23	Chromsome breakage (HP:0040012)	3.27784046
24	Malnutrition (HP:0004395)	3.22675656
25	Broad face (HP:0000283)	3.17228384
26	Mildly elevated creatine phosphokinase (HP:0008180)	3.02525878
27	Nuclear cataract (HP:0100018)	2.99029927
28	Ureteral duplication (HP:0000073)	2.97204216
29	Fragile skin (HP:0001030)	2.97037556
30	Short 1st metacarpal (HP:0010034)	2.91677620
31	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.91677620
32	Abnormality of DNA repair (HP:0003254)	2.89652406
33	Abnormality of the 1st metacarpal (HP:0010009)	2.86313099
34	Widely patent fontanelles and sutures (HP:0004492)	2.85938431
35	Abnormality of pyrimidine metabolism (HP:0004353)	2.81967059
36	Abnormality of the renal collecting system (HP:0004742)	2.80181405
37	Spinal muscular atrophy (HP:0007269)	2.78624068
38	Abnormality of the costochondral junction (HP:0000919)	2.78466449
39	Periorbital edema (HP:0100539)	2.67444254
40	Abnormality of the distal phalanges of the toes (HP:0010182)	2.63631448
41	Hyperactive renin-angiotensin system (HP:0000841)	2.60318226
42	Lower limb amyotrophy (HP:0007210)	2.60070912
43	Cystic liver disease (HP:0006706)	2.59490830
44	Atrophic scars (HP:0001075)	2.58673880
45	Facial edema (HP:0000282)	2.56621675
46	Ectopic kidney (HP:0000086)	2.56618951
47	Bony spicule pigmentary retinopathy (HP:0007737)	2.52271426
48	Follicular hyperkeratosis (HP:0007502)	2.50226308
49	Broad metatarsal (HP:0001783)	2.49292599
50	Short nail (HP:0001799)	2.47605211
51	Neonatal short-limb short stature (HP:0008921)	2.43802272
52	Short phalanx of the thumb (HP:0009660)	2.42690516
53	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.42610328
54	Patent foramen ovale (HP:0001655)	2.41899682
55	Increased connective tissue (HP:0009025)	2.34043806
56	Difficulty walking (HP:0002355)	2.32861803
57	Increased corneal curvature (HP:0100692)	2.26715076
58	Keratoconus (HP:0000563)	2.26715076
59	Duplication of thumb phalanx (HP:0009942)	2.25222441
60	Milia (HP:0001056)	2.23987730
61	Bronchomalacia (HP:0002780)	2.21793765
62	Premature rupture of membranes (HP:0001788)	2.19451036
63	Attenuation of retinal blood vessels (HP:0007843)	2.15290598
64	Hyperacusis (HP:0010780)	2.12613435
65	Onion bulb formation (HP:0003383)	2.11640947
66	Self-mutilation (HP:0000742)	2.10929292
67	Hand muscle atrophy (HP:0009130)	2.07716817
68	Abnormality of the dental pulp (HP:0006479)	2.06784675
69	Axonal loss (HP:0003447)	2.05043485
70	Abnormal trabecular bone morphology (HP:0100671)	2.04893068
71	Abnormality of the carotid arteries (HP:0005344)	2.04773773
72	Difficulty climbing stairs (HP:0003551)	2.03874411
73	Premature skin wrinkling (HP:0100678)	2.03223139
74	Severe visual impairment (HP:0001141)	1.97827414
75	Abnormality of the preputium (HP:0100587)	1.97250208
76	Aortic dissection (HP:0002647)	1.97176595
77	Abnormality of potassium homeostasis (HP:0011042)	1.97154651
78	Morphological abnormality of the middle ear (HP:0008609)	1.95369951
79	Male infertility (HP:0003251)	1.93632860
80	Decreased circulating renin level (HP:0003351)	1.91965677
81	Femoral bowing (HP:0002980)	1.91391886
82	Flat occiput (HP:0005469)	1.91099227
83	Pendular nystagmus (HP:0012043)	1.87736344
84	Aneurysm (HP:0002617)	1.86324896
85	Progressive sensorineural hearing impairment (HP:0000408)	1.82919833
86	Wide cranial sutures (HP:0010537)	1.82784144
87	Abnormality of renin-angiotensin system (HP:0000847)	1.81923534
88	Abnormality of the ileum (HP:0001549)	1.81629173
89	Tracheomalacia (HP:0002779)	1.77812781
90	Long eyelashes (HP:0000527)	1.77491196
91	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	1.76423741
92	Soft skin (HP:0000977)	1.76274006
93	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.75926453
94	Meckel diverticulum (HP:0002245)	1.75258263
95	Metaphyseal irregularity (HP:0003025)	1.75223392
96	Spondylolisthesis (HP:0003302)	1.74064768
97	Bladder diverticulum (HP:0000015)	1.72576911
98	Mitral valve prolapse (HP:0001634)	1.72027429
99	Mild short stature (HP:0003502)	1.71858645
100	Rickets (HP:0002748)	1.70158123

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST1R	8.78032861
2	WNK4	8.42452298
3	NME1	5.85672606
4	MET	3.56408535
5	WNK1	3.45144218
6	CDK12	2.75017029
7	FRK	2.54777716
8	MUSK	1.74665708
9	LMTK2	1.74224511
10	NEK2	1.59812500
11	MAP3K13	1.49132605
12	MAP2K6	1.46233858
13	STK39	1.44218791
14	DDR2	1.31733543
15	INSRR	1.24080254
16	BLK	1.23267160
17	SIK2	1.22548263
18	SIK1	1.16090889
19	ACVR1B	1.15055453
20	TRIB3	1.06978982
21	MAP4K2	1.03482812
22	ERN1	0.98679575
23	ERBB2	0.96675797
24	MAP3K7	0.96608893
25	CAMK1D	0.85420893
26	TNIK	0.77930653
27	MAP3K9	0.75502685
28	OXSR1	0.72476149
29	PRKCH	0.71935232
30	BRD4	0.69231723
31	CAMK1G	0.68109603
32	MTOR	0.64613419
33	PIK3CG	0.63579894
34	MARK2	0.63005055
35	TNK2	0.62922117
36	FGFR4	0.61974834
37	TRPM7	0.57140912
38	SGK1	0.55810703
39	MAP3K6	0.55579804
40	PHKG2	0.54350092
41	PHKG1	0.54350092
42	ICK	0.52604357
43	NTRK1	0.51369867
44	PDGFRB	0.49828109
45	CDC42BPA	0.46983396
46	PRKAA2	0.46923100
47	CDK9	0.41559345
48	BMPR1B	0.40885683
49	MKNK1	0.40215546
50	RIPK1	0.39660939
51	PRKAA1	0.39158979
52	MELK	0.36351894
53	ZAK	0.36177671
54	TEC	0.34350775
55	RET	0.34345146
56	CASK	0.34030260
57	MAPK11	0.33006108
58	PTK2B	0.32375173
59	PRKD2	0.32203902
60	PRKG2	0.32153733
61	PIK3CA	0.30420977
62	PASK	0.27140587
63	PDK1	0.26507976
64	MAP2K2	0.25711455
65	EPHA2	0.24879127
66	FER	0.23690989
67	MAPK1	0.21989488
68	AKT1	0.21313503
69	CSF1R	0.21260604
70	ATR	0.20598144
71	TAOK1	0.20570035
72	PDGFRA	0.19733994
73	RPS6KA6	0.19327268
74	FES	0.19158067
75	PKN2	0.19153335
76	ITK	0.17306225
77	RPS6KA3	0.16867869
78	CHEK1	0.16829689
79	KIT	0.16699336
80	MKNK2	0.16406786
81	GSK3B	0.16262713
82	PDPK1	0.15903734
83	CAMK2B	0.15769724
84	FGFR2	0.14578703
85	RPS6KA2	0.14492457
86	IGF1R	0.14489262
87	TAOK2	0.14443638
88	CHUK	0.14396204
89	ADRBK1	0.13966947
90	PRKDC	0.13582109
91	MAPK3	0.13112634
92	CDK1	0.12881319
93	FYN	0.12333832
94	BTK	0.11956253
95	SRC	0.11614323
96	RPS6KC1	0.10705630
97	RPS6KL1	0.10705630
98	BRAF	0.10385516
99	CAMKK1	0.09799618
100	AKT3	0.09245025

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	4.07831140
2	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.94755968
3	Salivary secretion_Homo sapiens_hsa04970	3.42867812
4	ABC transporters_Homo sapiens_hsa02010	3.16348344
5	Oocyte meiosis_Homo sapiens_hsa04114	2.84227768
6	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.42993382
7	Vibrio cholerae infection_Homo sapiens_hsa05110	2.34065738
8	ECM-receptor interaction_Homo sapiens_hsa04512	2.16834470
9	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	2.14017683
10	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.97908477
11	Protein digestion and absorption_Homo sapiens_hsa04974	1.97752025
12	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.95508172
13	Amoebiasis_Homo sapiens_hsa05146	1.81239598
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.69317656
15	Circadian entrainment_Homo sapiens_hsa04713	1.68361153
16	Taste transduction_Homo sapiens_hsa04742	1.62623547
17	Olfactory transduction_Homo sapiens_hsa04740	1.61144644
18	Lysine degradation_Homo sapiens_hsa00310	1.56282092
19	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.54179404
20	Insulin secretion_Homo sapiens_hsa04911	1.54058883
21	Gastric acid secretion_Homo sapiens_hsa04971	1.51842753
22	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.45536148
23	Bile secretion_Homo sapiens_hsa04976	1.41792486
24	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.35748398
25	Arginine and proline metabolism_Homo sapiens_hsa00330	1.34929092
26	Pancreatic secretion_Homo sapiens_hsa04972	1.29566772
27	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.24190057
28	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.18304052
29	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.16910781
30	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.12637834
31	Glycerolipid metabolism_Homo sapiens_hsa00561	1.11428801
32	Calcium signaling pathway_Homo sapiens_hsa04020	1.09834702
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.05923949
34	Other glycan degradation_Homo sapiens_hsa00511	1.05068354
35	Glutamatergic synapse_Homo sapiens_hsa04724	1.03570522
36	GnRH signaling pathway_Homo sapiens_hsa04912	1.03204471
37	Cholinergic synapse_Homo sapiens_hsa04725	0.96615655
38	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.96145119
39	Platelet activation_Homo sapiens_hsa04611	0.93768945
40	Arginine biosynthesis_Homo sapiens_hsa00220	0.92980855
41	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.92921458
42	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.89647755
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.87801448
44	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.87748549
45	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.86603101
46	Serotonergic synapse_Homo sapiens_hsa04726	0.84627155
47	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.83325788
48	Notch signaling pathway_Homo sapiens_hsa04330	0.79726145
49	Homologous recombination_Homo sapiens_hsa03440	0.79357715
50	Morphine addiction_Homo sapiens_hsa05032	0.77891752
51	cAMP signaling pathway_Homo sapiens_hsa04024	0.77712039
52	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.76864902
53	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.76643004
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74770115
55	Long-term potentiation_Homo sapiens_hsa04720	0.74035706
56	Type II diabetes mellitus_Homo sapiens_hsa04930	0.72914471
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.72254204
58	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.71948881
59	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.70958262
60	Focal adhesion_Homo sapiens_hsa04510	0.70157592
61	Nicotine addiction_Homo sapiens_hsa05033	0.68411720
62	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.67177576
63	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.67027561
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.66356422
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65850541
66	Phototransduction_Homo sapiens_hsa04744	0.62244392
67	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.61461314
68	Tight junction_Homo sapiens_hsa04530	0.61289625
69	Estrogen signaling pathway_Homo sapiens_hsa04915	0.60021339
70	Tryptophan metabolism_Homo sapiens_hsa00380	0.59282073
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.59257506
72	Long-term depression_Homo sapiens_hsa04730	0.58533131
73	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.58376815
74	Choline metabolism in cancer_Homo sapiens_hsa05231	0.58151622
75	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.57800218
76	Glucagon signaling pathway_Homo sapiens_hsa04922	0.55595888
77	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.55203866
78	GABAergic synapse_Homo sapiens_hsa04727	0.54762899
79	Renin secretion_Homo sapiens_hsa04924	0.53463330
80	Mineral absorption_Homo sapiens_hsa04978	0.50305917
81	Cocaine addiction_Homo sapiens_hsa05030	0.49027075
82	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.46685328
83	Retinol metabolism_Homo sapiens_hsa00830	0.44471036
84	Galactose metabolism_Homo sapiens_hsa00052	0.44421076
85	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.41286789
86	Gap junction_Homo sapiens_hsa04540	0.40787955
87	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.39998898
88	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.38868588
89	One carbon pool by folate_Homo sapiens_hsa00670	0.37932021
90	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.37928687
91	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.37102236
92	Amphetamine addiction_Homo sapiens_hsa05031	0.35430178
93	Butanoate metabolism_Homo sapiens_hsa00650	0.35203601
94	Insulin resistance_Homo sapiens_hsa04931	0.34308535
95	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.34023241
96	Small cell lung cancer_Homo sapiens_hsa05222	0.33749061
97	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.32204091
98	Adherens junction_Homo sapiens_hsa04520	0.31224337
99	Ether lipid metabolism_Homo sapiens_hsa00565	0.29246496
100	Purine metabolism_Homo sapiens_hsa00230	0.25186244

USP17L11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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