USP17L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K9 demethylation (GO:0033169)5.02608703
2neuron cell-cell adhesion (GO:0007158)4.88252839
3postsynaptic membrane organization (GO:0001941)4.84491978
4membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.73444531
5tachykinin receptor signaling pathway (GO:0007217)4.36596007
6behavioral response to nicotine (GO:0035095)4.28920730
7startle response (GO:0001964)4.25361054
8presynaptic membrane assembly (GO:0097105)4.23077118
9membrane depolarization during action potential (GO:0086010)4.19987295
10gamma-aminobutyric acid transport (GO:0015812)4.02059934
11neuron fate determination (GO:0048664)3.95727892
12G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.90579909
13transmission of nerve impulse (GO:0019226)3.88722986
14gamma-aminobutyric acid signaling pathway (GO:0007214)3.83169564
15multicellular organism reproduction (GO:0032504)3.71904021
16establishment of protein localization to Golgi (GO:0072600)3.63032038
17presynaptic membrane organization (GO:0097090)3.62105423
18detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.60906448
19neuronal action potential (GO:0019228)3.48350300
20C4-dicarboxylate transport (GO:0015740)3.46827029
21cochlea development (GO:0090102)3.43850744
22negative regulation of inclusion body assembly (GO:0090084)3.43824308
23retina layer formation (GO:0010842)3.40565938
24cell morphogenesis involved in neuron differentiation (GO:0048667)3.39914704
25neurotransmitter-gated ion channel clustering (GO:0072578)3.37419866
26cerebral cortex radially oriented cell migration (GO:0021799)3.34227162
27regulation of female receptivity (GO:0045924)3.32383689
28central nervous system myelination (GO:0022010)3.32065671
29axon ensheathment in central nervous system (GO:0032291)3.32065671
30cilium or flagellum-dependent cell motility (GO:0001539)3.19464206
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.15919617
32vocalization behavior (GO:0071625)3.12391792
33adult walking behavior (GO:0007628)3.10937976
34acrosome reaction (GO:0007340)3.09264844
35radial glial cell differentiation (GO:0060019)3.09196232
36activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.08003093
37L-fucose catabolic process (GO:0042355)3.07529621
38fucose catabolic process (GO:0019317)3.07529621
39L-fucose metabolic process (GO:0042354)3.07529621
40reflex (GO:0060004)3.07350685
41protein targeting to Golgi (GO:0000042)3.06915222
42motile cilium assembly (GO:0044458)3.06617127
43negative regulation of mast cell activation (GO:0033004)3.05718280
44cellular response to sterol (GO:0036315)3.05557801
45glutamate receptor signaling pathway (GO:0007215)3.02830428
46histone H3-K36 demethylation (GO:0070544)2.99921397
47neuronal action potential propagation (GO:0019227)2.99779653
48gonadal mesoderm development (GO:0007506)2.97574798
49female mating behavior (GO:0060180)2.93049070
50spinal cord motor neuron differentiation (GO:0021522)2.91863534
51positive regulation of meiosis (GO:0045836)2.91747111
52positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.90612838
53dendritic spine morphogenesis (GO:0060997)2.90563988
54ionotropic glutamate receptor signaling pathway (GO:0035235)2.90126481
55mechanosensory behavior (GO:0007638)2.87340325
56regulation of short-term neuronal synaptic plasticity (GO:0048172)2.83432221
57regulation of acrosome reaction (GO:0060046)2.83315586
58somite development (GO:0061053)2.80677658
59protein localization to synapse (GO:0035418)2.80458875
60retrograde transport, vesicle recycling within Golgi (GO:0000301)2.80087105
61microtubule nucleation (GO:0007020)2.73880546
62regulation of synaptic transmission, glutamatergic (GO:0051966)2.72907181
63positive regulation of meiotic cell cycle (GO:0051446)2.72818757
64chemosensory behavior (GO:0007635)2.71127807
65detection of light stimulus involved in sensory perception (GO:0050962)2.70786011
66detection of light stimulus involved in visual perception (GO:0050908)2.70786011
67retinal cone cell development (GO:0046549)2.69786580
68regulation of feeding behavior (GO:0060259)2.67055185
69serotonin metabolic process (GO:0042428)2.67041623
70positive regulation of uterine smooth muscle contraction (GO:0070474)2.66852227
71cellular response to cholesterol (GO:0071397)2.66521349
72telencephalon development (GO:0021537)2.66138253
73protein polyglutamylation (GO:0018095)2.64429796
74calcium ion import (GO:0070509)2.61975740
75positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.60926722
76detection of mechanical stimulus involved in sensory perception (GO:0050974)2.60401780
77righting reflex (GO:0060013)2.59978034
78synaptonemal complex organization (GO:0070193)2.59741620
79indolalkylamine metabolic process (GO:0006586)2.59552038
80microtubule polymerization or depolymerization (GO:0031109)2.59120465
81calcium ion-dependent exocytosis (GO:0017156)2.58813046
82auditory behavior (GO:0031223)2.57798660
83sperm motility (GO:0030317)2.57356490
84negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.57245849
85membrane depolarization (GO:0051899)2.55283962
86action potential (GO:0001508)2.55249251
87behavioral defense response (GO:0002209)2.54521731
88behavioral fear response (GO:0001662)2.54521731
89cilium movement (GO:0003341)2.52847032
90central nervous system neuron axonogenesis (GO:0021955)2.51874495
91central nervous system projection neuron axonogenesis (GO:0021952)2.51599904
92primary amino compound metabolic process (GO:1901160)2.50743452
93regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.50670305
94histone lysine demethylation (GO:0070076)2.49795327
95regulation of synaptic transmission, GABAergic (GO:0032228)2.49439342
96synaptic transmission, glutamatergic (GO:0035249)2.48891452
97limb development (GO:0060173)2.46956865
98appendage development (GO:0048736)2.46956865
99neurogenesis (GO:0022008)2.46120125
100indolalkylamine catabolic process (GO:0046218)2.46024807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.37259757
2GBX2_23144817_ChIP-Seq_PC3_Human3.86358461
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.02812962
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.97895669
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.92410218
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68699950
7AR_21572438_ChIP-Seq_LNCaP_Human2.56135841
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.55938621
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53948874
10IGF1R_20145208_ChIP-Seq_DFB_Human2.45859576
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.34565174
12VDR_22108803_ChIP-Seq_LS180_Human2.31463495
13DROSHA_22980978_ChIP-Seq_HELA_Human2.29711859
14TAF15_26573619_Chip-Seq_HEK293_Human2.11105199
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99001033
16SMAD4_21799915_ChIP-Seq_A2780_Human1.98806404
17P300_19829295_ChIP-Seq_ESCs_Human1.97599493
18PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.97186931
19ZNF274_21170338_ChIP-Seq_K562_Hela1.96222432
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.93981836
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91640587
22REST_21632747_ChIP-Seq_MESCs_Mouse1.89423342
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82924066
24STAT3_23295773_ChIP-Seq_U87_Human1.81950715
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.81763010
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78724452
27EWS_26573619_Chip-Seq_HEK293_Human1.76217907
28SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.73589580
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73061270
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69636116
31TCF4_23295773_ChIP-Seq_U87_Human1.65761783
32ER_23166858_ChIP-Seq_MCF-7_Human1.64968797
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.64748739
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.64443364
35FUS_26573619_Chip-Seq_HEK293_Human1.61991801
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.61965255
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.61873746
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61223834
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.60687220
40SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57914933
41BCAT_22108803_ChIP-Seq_LS180_Human1.57779949
42AR_25329375_ChIP-Seq_VCAP_Human1.53008118
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49804939
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49079698
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46849262
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45976186
47RUNX2_22187159_ChIP-Seq_PCA_Human1.45415505
48RNF2_27304074_Chip-Seq_NSC_Mouse1.44066195
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43007693
50PRDM14_20953172_ChIP-Seq_ESCs_Human1.42610930
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37938158
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37906917
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.36715968
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34505394
55CBP_20019798_ChIP-Seq_JUKART_Human1.33046452
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33046452
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31826505
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30139187
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30139187
60SMAD4_21741376_ChIP-Seq_EPCs_Human1.28602036
61KDM2B_26808549_Chip-Seq_REH_Human1.28080611
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27207338
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27207338
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26980015
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26395225
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.25019044
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24394122
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22040909
69TCF4_22108803_ChIP-Seq_LS180_Human1.21564161
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.21054402
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19994781
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19904940
73MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18776907
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.18750890
75CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17297788
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15411656
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14663458
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14488539
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14121487
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13378123
81RXR_22108803_ChIP-Seq_LS180_Human1.13203773
82SMAD4_21741376_ChIP-Seq_HESCs_Human1.12467270
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09952657
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09947703
85TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09509989
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.09191003
87CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09075417
88IRF1_19129219_ChIP-ChIP_H3396_Human1.08762014
89SMAD3_21741376_ChIP-Seq_HESCs_Human1.06901067
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06629460
91AR_19668381_ChIP-Seq_PC3_Human1.06302207
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.05953087
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05594237
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05079312
95TBL1_22424771_ChIP-Seq_293T_Human1.01942348
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01735032
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01626839
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01370353
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.98371116
100PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97808495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.64375245
2MP0000569_abnormal_digit_pigmentation4.08066064
3MP0006292_abnormal_olfactory_placode2.97304600
4MP0001501_abnormal_sleep_pattern2.74110175
5MP0002102_abnormal_ear_morphology2.61235828
6MP0001485_abnormal_pinna_reflex2.50801819
7MP0009745_abnormal_behavioral_response2.40345164
8MP0009046_muscle_twitch2.36856756
9MP0001486_abnormal_startle_reflex2.29267248
10MP0005551_abnormal_eye_electrophysiolog2.14124361
11MP0003879_abnormal_hair_cell2.12919881
12MP0001968_abnormal_touch/_nociception2.11572105
13MP0002735_abnormal_chemical_nociception2.08403349
14MP0003635_abnormal_synaptic_transmissio2.05483802
15MP0000778_abnormal_nervous_system2.04959675
16MP0002064_seizures2.02725433
17MP0002272_abnormal_nervous_system1.99169775
18MP0002736_abnormal_nociception_after1.94887542
19MP0000631_abnormal_neuroendocrine_gland1.94355339
20MP0004859_abnormal_synaptic_plasticity1.94321384
21MP0004270_analgesia1.89460797
22MP0006276_abnormal_autonomic_nervous1.88346019
23MP0003950_abnormal_plasma_membrane1.87579278
24MP0004885_abnormal_endolymph1.85251957
25MP0004742_abnormal_vestibular_system1.79183016
26MP0002572_abnormal_emotion/affect_behav1.75829738
27MP0002067_abnormal_sensory_capabilities1.74269283
28MP0001963_abnormal_hearing_physiology1.70056824
29MP0001440_abnormal_grooming_behavior1.65246974
30MP0003136_yellow_coat_color1.61806283
31MP0002638_abnormal_pupillary_reflex1.56164966
32MP0003183_abnormal_peptide_metabolism1.53341368
33MP0001502_abnormal_circadian_rhythm1.53337863
34MP0004142_abnormal_muscle_tone1.51815898
35MP0005410_abnormal_fertilization1.50943381
36MP0005253_abnormal_eye_physiology1.48677462
37MP0002063_abnormal_learning/memory/cond1.47617297
38MP0000015_abnormal_ear_pigmentation1.45131969
39MP0002653_abnormal_ependyma_morphology1.43535108
40MP0003283_abnormal_digestive_organ1.42684537
41MP0000026_abnormal_inner_ear1.42038513
42MP0005187_abnormal_penis_morphology1.42005111
43MP0001984_abnormal_olfaction1.41502198
44MP0001666_abnormal_nutrient_absorption1.41452373
45MP0000955_abnormal_spinal_cord1.39686764
46MP0000427_abnormal_hair_cycle1.37927357
47MP0003868_abnormal_feces_composition1.35285335
48MP0002734_abnormal_mechanical_nocicepti1.35284909
49MP0008872_abnormal_physiological_respon1.34489367
50MP0002229_neurodegeneration1.34237546
51MP0002938_white_spotting1.29810612
52MP0005503_abnormal_tendon_morphology1.27361343
53MP0003880_abnormal_central_pattern1.27109017
54MP0002882_abnormal_neuron_morphology1.25498109
55MP0006072_abnormal_retinal_apoptosis1.24661873
56MP0001664_abnormal_digestion1.24168419
57MP0005386_behavior/neurological_phenoty1.23207103
58MP0004924_abnormal_behavior1.23207103
59MP0002557_abnormal_social/conspecific_i1.22682622
60MP0008058_abnormal_DNA_repair1.22596725
61MP0000049_abnormal_middle_ear1.22156137
62MP0003698_abnormal_male_reproductive1.20128837
63MP0002752_abnormal_somatic_nervous1.19926688
64MP0002184_abnormal_innervation1.18942358
65MP0005195_abnormal_posterior_eye1.15392440
66MP0004043_abnormal_pH_regulation1.14914375
67MP0002733_abnormal_thermal_nociception1.14445358
68MP0005084_abnormal_gallbladder_morpholo1.13587914
69MP0002928_abnormal_bile_duct1.12881068
70MP0001970_abnormal_pain_threshold1.12456220
71MP0002095_abnormal_skin_pigmentation1.11818129
72MP0005423_abnormal_somatic_nervous1.11658368
73MP0005670_abnormal_white_adipose1.10706350
74MP0005171_absent_coat_pigmentation1.08565665
75MP0005646_abnormal_pituitary_gland1.07309429
76MP0001929_abnormal_gametogenesis1.02859869
77MP0005394_taste/olfaction_phenotype1.02149138
78MP0005499_abnormal_olfactory_system1.02149138
79MP0004134_abnormal_chest_morphology1.00996897
80MP0002249_abnormal_larynx_morphology1.00603604
81MP0005377_hearing/vestibular/ear_phenot1.00228735
82MP0003878_abnormal_ear_physiology1.00228735
83MP0002751_abnormal_autonomic_nervous0.96927340
84MP0003633_abnormal_nervous_system0.95929024
85MP0000462_abnormal_digestive_system0.95148012
86MP0008569_lethality_at_weaning0.91093436
87MP0000566_synostosis0.89797756
88MP0004145_abnormal_muscle_electrophysio0.88081033
89MP0002066_abnormal_motor_capabilities/c0.86468715
90MP0008789_abnormal_olfactory_epithelium0.85912483
91MP0003119_abnormal_digestive_system0.85874797
92MP0002152_abnormal_brain_morphology0.84757723
93MP0001529_abnormal_vocalization0.82988664
94MP0005220_abnormal_exocrine_pancreas0.82276956
95MP0003631_nervous_system_phenotype0.81809710
96MP0004811_abnormal_neuron_physiology0.80120180
97MP0003045_fibrosis0.76003195
98MP0005391_vision/eye_phenotype0.73495053
99MP0002160_abnormal_reproductive_system0.72558688
100MP0002210_abnormal_sex_determination0.72077903

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.37810529
2Focal seizures (HP:0007359)3.56056471
3Neoplasm of the heart (HP:0100544)3.46138835
4Short 4th metacarpal (HP:0010044)3.46063663
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.46063663
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.45906282
7Absent/shortened dynein arms (HP:0200106)3.45906282
8Abnormality of the nasal septum (HP:0000419)3.44201417
9Bilateral microphthalmos (HP:0007633)3.39746882
10Febrile seizures (HP:0002373)3.33381411
11True hermaphroditism (HP:0010459)3.26797146
12Abnormal number of incisors (HP:0011064)3.18935933
13Atonic seizures (HP:0010819)3.16972642
14Hyperventilation (HP:0002883)3.15057046
15Pancreatic fibrosis (HP:0100732)3.13287457
16Abnormality of the renal cortex (HP:0011035)3.06929445
17Pancreatic cysts (HP:0001737)2.99329352
18Gaze-evoked nystagmus (HP:0000640)2.93772544
19Abnormal ciliary motility (HP:0012262)2.90244204
20Progressive cerebellar ataxia (HP:0002073)2.89522915
21Hemiparesis (HP:0001269)2.87950920
22Congenital stationary night blindness (HP:0007642)2.80284721
23Epileptic encephalopathy (HP:0200134)2.79867703
24Dialeptic seizures (HP:0011146)2.77594480
25Optic nerve coloboma (HP:0000588)2.75616629
26Aplasia/Hypoplasia of the sternum (HP:0006714)2.74025594
27Nephrogenic diabetes insipidus (HP:0009806)2.73497541
28Medial flaring of the eyebrow (HP:0010747)2.69799609
29Abnormality of the renal medulla (HP:0100957)2.69192907
30Fibular hypoplasia (HP:0003038)2.65946415
31Gait imbalance (HP:0002141)2.64798708
32Nephronophthisis (HP:0000090)2.62261212
33Genetic anticipation (HP:0003743)2.50830287
34Chronic hepatic failure (HP:0100626)2.50352002
35Molar tooth sign on MRI (HP:0002419)2.49192572
36Abnormality of midbrain morphology (HP:0002418)2.49192572
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46215744
38Abnormality of the diencephalon (HP:0010662)2.45642949
39Congenital sensorineural hearing impairment (HP:0008527)2.45492659
40Duplicated collecting system (HP:0000081)2.43494198
41Depressed nasal tip (HP:0000437)2.42936457
42Cystic liver disease (HP:0006706)2.41707181
43Abnormality of the 4th metacarpal (HP:0010012)2.40368213
44Glioma (HP:0009733)2.40164105
45Abnormality of the renal collecting system (HP:0004742)2.39652510
46Midline defect of the nose (HP:0004122)2.38657046
47Congenital primary aphakia (HP:0007707)2.36538349
48Ectopic kidney (HP:0000086)2.35020924
49Tubulointerstitial nephritis (HP:0001970)2.23745572
50Down-sloping shoulders (HP:0200021)2.21766453
51Genital tract atresia (HP:0001827)2.21151943
52Epileptiform EEG discharges (HP:0011182)2.20169602
53Decreased circulating renin level (HP:0003351)2.19413652
54Abolished electroretinogram (ERG) (HP:0000550)2.17966123
55Truncal obesity (HP:0001956)2.16454192
56Neoplasm of the oral cavity (HP:0100649)2.15322049
57Sclerocornea (HP:0000647)2.15253753
58Aplasia/Hypoplasia of the tibia (HP:0005772)2.13645598
59Broad-based gait (HP:0002136)2.13618270
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.12795420
61Hemiplegia (HP:0002301)2.11468856
62Hypsarrhythmia (HP:0002521)2.11448912
63Partial agenesis of the corpus callosum (HP:0001338)2.10803046
64EEG with generalized epileptiform discharges (HP:0011198)2.10044998
65Chromsome breakage (HP:0040012)2.09737332
66Oligodactyly (hands) (HP:0001180)2.09253528
67Abnormal respiratory motile cilium physiology (HP:0012261)2.09207726
68Poor eye contact (HP:0000817)2.08984529
69Tubulointerstitial abnormality (HP:0001969)2.06520061
70Volvulus (HP:0002580)2.01794340
71Abnormality of the incisor (HP:0000676)2.01570228
72Vaginal atresia (HP:0000148)2.00315982
73Tubular atrophy (HP:0000092)1.99091732
74Abnormality of binocular vision (HP:0011514)1.98722046
75Diplopia (HP:0000651)1.98722046
76Absence seizures (HP:0002121)1.98169265
77Widely spaced teeth (HP:0000687)1.97763084
78Abnormality of the ischium (HP:0003174)1.97164688
79Short phalanx of the thumb (HP:0009660)1.95662627
80Poor coordination (HP:0002370)1.94250020
81Urinary bladder sphincter dysfunction (HP:0002839)1.92328908
82Palpebral edema (HP:0100540)1.89762480
83Hypoplastic ischia (HP:0003175)1.88736381
84Attenuation of retinal blood vessels (HP:0007843)1.88337022
85Supernumerary ribs (HP:0005815)1.88042089
86Morphological abnormality of the middle ear (HP:0008609)1.86474359
87Supernumerary bones of the axial skeleton (HP:0009144)1.85663905
88Broad face (HP:0000283)1.85657963
89Bony spicule pigmentary retinopathy (HP:0007737)1.85483480
90Abnormal respiratory motile cilium morphology (HP:0005938)1.85055038
91Abnormal respiratory epithelium morphology (HP:0012253)1.85055038
92Neoplasm of striated muscle (HP:0009728)1.83476907
93Tented upper lip vermilion (HP:0010804)1.83427972
94Fair hair (HP:0002286)1.83395369
95Tubulointerstitial fibrosis (HP:0005576)1.81960855
96Degeneration of the lateral corticospinal tracts (HP:0002314)1.81134377
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81134377
98Abnormality of the parietal bone (HP:0002696)1.79578019
99Growth hormone deficiency (HP:0000824)1.77827022
100Aplasia/Hypoplasia of the fibula (HP:0006492)1.77745102

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.74775019
2PNCK3.67956609
3INSRR3.16848959
4CASK2.92788613
5MARK12.54786479
6GRK12.48659561
7CDK122.40989767
8NTRK32.38249383
9MAPK152.37524339
10ADRBK22.28633435
11MAP3K42.24735450
12MAP4K22.14719812
13NUAK12.02323100
14TNIK1.98767418
15LATS11.89801305
16SIK21.86309663
17BRSK21.85171857
18TAOK31.74945121
19PLK41.60479227
20VRK11.58204606
21MAPK131.57419364
22DYRK31.51584045
23BMPR1B1.51096053
24PKN11.46135708
25TYRO31.41518022
26STK38L1.38028566
27NTRK21.35452068
28CDK31.33645264
29SGK21.33606094
30ACVR1B1.30642002
31MAP3K91.29819179
32TSSK61.25235676
33TEC1.17493684
34PBK1.16838337
35SGK4941.10566374
36SGK2231.10566374
37STK391.06200271
38DYRK21.06194113
39DYRK1A1.03387397
40CAMK1G1.00305438
41MARK30.95835022
42CDK190.95349794
43ZAK0.91716881
44MAPKAPK50.90372746
45WNK10.86275227
46OXSR10.86060575
47PRKCE0.84935878
48EPHA40.84262889
49WNK40.81356895
50STK380.79930621
51PTK2B0.79915565
52PRKCG0.78033267
53BRD40.75306759
54CAMK40.74042490
55CAMK2A0.70683732
56NLK0.68020305
57NME10.66292403
58RPS6KA50.66094200
59DDR20.63203114
60CSNK1G10.62211313
61WNK30.60781838
62GRK50.58813233
63PASK0.56626903
64CCNB10.56582851
65STK160.56530846
66SGK10.56523821
67CDK50.54048978
68CAMK2B0.52391686
69LIMK10.51152957
70FGFR30.51099979
71CAMK10.50555492
72PRKG10.49443485
73PINK10.49078419
74EPHB10.48809817
75DAPK20.48483809
76MAP2K70.48178906
77CAMKK10.48070574
78TESK20.47267637
79CHEK20.45352158
80RPS6KA30.44880153
81BCR0.44790294
82PRKAA10.44658945
83AKT30.44167879
84ADRBK10.43880863
85TNK20.42326139
86CAMKK20.41448518
87CSNK1A10.41309314
88DAPK10.38878711
89PRKACA0.38831966
90PRKACB0.38078870
91DMPK0.35614159
92GSK3B0.35413890
93CSNK1D0.34251876
94PRKCB0.34039511
95CSNK1A1L0.32788493
96DYRK1B0.31717920
97ICK0.30453511
98MAPK120.29447103
99GSK3A0.29180010
100BMPR20.28250998

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.91084788
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.07039160
3Pancreatic secretion_Homo sapiens_hsa049722.73530993
4GABAergic synapse_Homo sapiens_hsa047272.72629951
5Morphine addiction_Homo sapiens_hsa050322.62261529
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57622563
7Phototransduction_Homo sapiens_hsa047442.56345329
8Taste transduction_Homo sapiens_hsa047422.47721743
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.44805238
10Circadian entrainment_Homo sapiens_hsa047132.38406702
11Glutamatergic synapse_Homo sapiens_hsa047242.37730146
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.16291983
13Insulin secretion_Homo sapiens_hsa049112.09720613
14Cocaine addiction_Homo sapiens_hsa050301.97135498
15Olfactory transduction_Homo sapiens_hsa047401.80412943
16Cholinergic synapse_Homo sapiens_hsa047251.66529317
17Serotonergic synapse_Homo sapiens_hsa047261.65861960
18Protein digestion and absorption_Homo sapiens_hsa049741.50762108
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50381803
20Salivary secretion_Homo sapiens_hsa049701.47475184
21Linoleic acid metabolism_Homo sapiens_hsa005911.47144650
22Dorso-ventral axis formation_Homo sapiens_hsa043201.47132231
23Dopaminergic synapse_Homo sapiens_hsa047281.46708745
24Amphetamine addiction_Homo sapiens_hsa050311.43102501
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.42091101
26Butanoate metabolism_Homo sapiens_hsa006501.40590291
27Fat digestion and absorption_Homo sapiens_hsa049751.39689649
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38938877
29ABC transporters_Homo sapiens_hsa020101.35755272
30Nitrogen metabolism_Homo sapiens_hsa009101.34401090
31Fanconi anemia pathway_Homo sapiens_hsa034601.33481253
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30426458
33cAMP signaling pathway_Homo sapiens_hsa040241.29175840
34Calcium signaling pathway_Homo sapiens_hsa040201.28559487
35Hedgehog signaling pathway_Homo sapiens_hsa043401.26873877
36Glycerolipid metabolism_Homo sapiens_hsa005611.22317565
37Selenocompound metabolism_Homo sapiens_hsa004501.20833110
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.19114085
39Basal cell carcinoma_Homo sapiens_hsa052171.17345269
40Gastric acid secretion_Homo sapiens_hsa049711.13366536
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05161912
42Type II diabetes mellitus_Homo sapiens_hsa049301.00001062
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.99609650
44Estrogen signaling pathway_Homo sapiens_hsa049150.95337980
45Ether lipid metabolism_Homo sapiens_hsa005650.94161634
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94154385
47Bile secretion_Homo sapiens_hsa049760.92528440
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92330244
49Chemical carcinogenesis_Homo sapiens_hsa052040.91597956
50Renin secretion_Homo sapiens_hsa049240.91563369
51Alcoholism_Homo sapiens_hsa050340.89056823
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87431458
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86945439
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84047240
55Oxytocin signaling pathway_Homo sapiens_hsa049210.81868253
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.81848257
57Tryptophan metabolism_Homo sapiens_hsa003800.80537805
58Synaptic vesicle cycle_Homo sapiens_hsa047210.80194213
59Retinol metabolism_Homo sapiens_hsa008300.78587950
60Ovarian steroidogenesis_Homo sapiens_hsa049130.75705777
61Oocyte meiosis_Homo sapiens_hsa041140.75208191
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74071153
63Long-term depression_Homo sapiens_hsa047300.70793062
64Histidine metabolism_Homo sapiens_hsa003400.69669071
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68525430
66ErbB signaling pathway_Homo sapiens_hsa040120.66527722
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64857621
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63941568
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63012382
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62555883
71Gap junction_Homo sapiens_hsa045400.61703567
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61492516
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59322825
74Long-term potentiation_Homo sapiens_hsa047200.58855220
75Basal transcription factors_Homo sapiens_hsa030220.57762179
76Fatty acid biosynthesis_Homo sapiens_hsa000610.52642427
77beta-Alanine metabolism_Homo sapiens_hsa004100.51588311
78PPAR signaling pathway_Homo sapiens_hsa033200.50699231
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50022958
80Ras signaling pathway_Homo sapiens_hsa040140.49593873
81Systemic lupus erythematosus_Homo sapiens_hsa053220.47021574
82GnRH signaling pathway_Homo sapiens_hsa049120.46155168
83MAPK signaling pathway_Homo sapiens_hsa040100.46089800
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45685192
85Regulation of autophagy_Homo sapiens_hsa041400.45576141
86Dilated cardiomyopathy_Homo sapiens_hsa054140.43447866
87Vitamin digestion and absorption_Homo sapiens_hsa049770.43252082
88Starch and sucrose metabolism_Homo sapiens_hsa005000.40031532
89Axon guidance_Homo sapiens_hsa043600.39436713
90Circadian rhythm_Homo sapiens_hsa047100.38045365
91Inositol phosphate metabolism_Homo sapiens_hsa005620.37209468
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35612083
93Tight junction_Homo sapiens_hsa045300.35254886
94Homologous recombination_Homo sapiens_hsa034400.35231847
95Collecting duct acid secretion_Homo sapiens_hsa049660.34286176
96Platelet activation_Homo sapiens_hsa046110.34098772
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.33473292
98Sulfur metabolism_Homo sapiens_hsa009200.32582091
99Rap1 signaling pathway_Homo sapiens_hsa040150.32546513
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31872813

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »