ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	intestinal cholesterol absorption (GO:0030299)	7.38505243
2	positive regulation of action potential (GO:0045760)	7.11388120
3	neuronal action potential (GO:0019228)	5.91079942
4	phosphatidylinositol acyl-chain remodeling (GO:0036149)	4.85580996
5	fusion of sperm to egg plasma membrane (GO:0007342)	4.81635468
6	detection of light stimulus involved in sensory perception (GO:0050962)	4.78595863
7	detection of light stimulus involved in visual perception (GO:0050908)	4.78595863
8	serotonin metabolic process (GO:0042428)	4.73123880
9	primary amino compound metabolic process (GO:1901160)	4.50408924
10	digestion (GO:0007586)	4.40093905
11	regulation of action potential (GO:0098900)	4.29589829
12	motile cilium assembly (GO:0044458)	4.25696619
13	protein polyglutamylation (GO:0018095)	4.15897150
14	phosphatidylserine acyl-chain remodeling (GO:0036150)	4.12892559
15	protein K11-linked deubiquitination (GO:0035871)	3.95329848
16	seminiferous tubule development (GO:0072520)	3.91362663
17	gamma-aminobutyric acid transport (GO:0015812)	3.85684198
18	urinary tract smooth muscle contraction (GO:0014848)	3.85129761
19	membrane depolarization during action potential (GO:0086010)	3.84108893
20	regulation of cell communication by electrical coupling (GO:0010649)	3.83864118
21	behavioral response to nicotine (GO:0035095)	3.83392560
22	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.81414497
23	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.80139326
24	positive regulation of cAMP-mediated signaling (GO:0043950)	3.72532197
25	cellular response to zinc ion (GO:0071294)	3.72431285
26	plasma membrane fusion (GO:0045026)	3.71205333
27	glycerophospholipid catabolic process (GO:0046475)	3.69988064
28	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.66001445
29	neuronal action potential propagation (GO:0019227)	3.65193098
30	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.59356533
31	positive regulation of guanylate cyclase activity (GO:0031284)	3.57374190
32	action potential (GO:0001508)	3.56797841
33	regulation of acrosome reaction (GO:0060046)	3.55722641
34	indole-containing compound metabolic process (GO:0042430)	3.51360086
35	parturition (GO:0007567)	3.49612132
36	phosphorelay signal transduction system (GO:0000160)	3.47185050
37	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.45457037
38	peristalsis (GO:0030432)	3.45079258
39	negative regulation of execution phase of apoptosis (GO:1900118)	3.36848422
40	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.34827048
41	receptor guanylyl cyclase signaling pathway (GO:0007168)	3.25683961
42	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.24658651
43	regulation of guanylate cyclase activity (GO:0031282)	3.23644686
44	phosphatidylcholine acyl-chain remodeling (GO:0036151)	3.23425903
45	synaptic transmission, glutamatergic (GO:0035249)	3.21109477
46	positive regulation of sodium ion transmembrane transport (GO:1902307)	3.14210384
47	glutamate receptor signaling pathway (GO:0007215)	3.12339338
48	positive T cell selection (GO:0043368)	3.11880452
49	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.11744312
50	rhodopsin mediated signaling pathway (GO:0016056)	3.09316950
51	transcytosis (GO:0045056)	3.08511700
52	imidazole-containing compound metabolic process (GO:0052803)	3.07163162
53	kynurenine metabolic process (GO:0070189)	3.07051409
54	axoneme assembly (GO:0035082)	3.06621797
55	fucose catabolic process (GO:0019317)	3.06405787
56	L-fucose metabolic process (GO:0042354)	3.06405787
57	L-fucose catabolic process (GO:0042355)	3.06405787
58	behavioral response to ethanol (GO:0048149)	2.99056944
59	regulation of sequestering of triglyceride (GO:0010889)	2.98241483
60	regulation of endothelial cell differentiation (GO:0045601)	2.96545765
61	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.94001392
62	regulation of hippo signaling (GO:0035330)	2.92764265
63	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.91815318
64	cytolysis (GO:0019835)	2.89002473
65	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.88753088
66	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.88753088
67	phospholipid catabolic process (GO:0009395)	2.87336482
68	cellular ketone body metabolic process (GO:0046950)	2.87164431
69	regulation of protein targeting to membrane (GO:0090313)	2.87092774
70	activated T cell proliferation (GO:0050798)	2.83583710
71	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.82226170
72	interkinetic nuclear migration (GO:0022027)	2.81704502
73	intestinal absorption (GO:0050892)	2.81368449
74	neuromuscular synaptic transmission (GO:0007274)	2.78622409
75	tryptophan catabolic process (GO:0006569)	2.77450313
76	indole-containing compound catabolic process (GO:0042436)	2.77450313
77	indolalkylamine catabolic process (GO:0046218)	2.77450313
78	prenylation (GO:0097354)	2.77052349
79	protein prenylation (GO:0018342)	2.77052349
80	T cell migration (GO:0072678)	2.74940451
81	startle response (GO:0001964)	2.74653553
82	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.74019001
83	regulation of mesoderm development (GO:2000380)	2.73096204
84	positive regulation of endothelial cell differentiation (GO:0045603)	2.71422207
85	histone H4-K12 acetylation (GO:0043983)	2.71290325
86	regulation of transcription involved in cell fate commitment (GO:0060850)	2.66297512
87	musculoskeletal movement (GO:0050881)	2.63647122
88	multicellular organismal movement (GO:0050879)	2.63647122
89	positive regulation of protein targeting to membrane (GO:0090314)	2.60514235
90	one-carbon compound transport (GO:0019755)	2.59872923
91	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.59489566
92	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.59489566
93	cholesterol catabolic process (GO:0006707)	2.58326988
94	sterol catabolic process (GO:0016127)	2.58326988
95	cerebellar Purkinje cell differentiation (GO:0021702)	2.54506075
96	aspartate family amino acid catabolic process (GO:0009068)	2.53012076
97	positive regulation of sodium ion transport (GO:0010765)	2.52866864
98	central nervous system myelination (GO:0022010)	2.51946945
99	axon ensheathment in central nervous system (GO:0032291)	2.51946945
100	ketone body metabolic process (GO:1902224)	2.51808079

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.95158763
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.64589944
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.08881070
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.08301938
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.48707280
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.35173379
7	DROSHA_22980978_ChIP-Seq_HELA_Human	2.26088816
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.18887198
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.15322028
10	VDR_22108803_ChIP-Seq_LS180_Human	2.10165479
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.02785138
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.01970692
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.79754443
14	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.76602636
15	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.74531920
16	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.74124642
17	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.71203424
18	P300_19829295_ChIP-Seq_ESCs_Human	1.71178328
19	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.69567781
20	REST_21632747_ChIP-Seq_MESCs_Mouse	1.68930201
21	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.65930576
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.65336390
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.56999308
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.56098402
25	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.55274224
26	STAT3_23295773_ChIP-Seq_U87_Human	1.53749549
27	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.53122670
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.53074360
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.53056470
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.51391129
31	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.47653901
32	RUNX2_22187159_ChIP-Seq_PCA_Human	1.40720014
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.39248415
34	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.38640282
35	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.38078209
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.37575461
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.36463188
38	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.36424646
39	TAF15_26573619_Chip-Seq_HEK293_Human	1.36020179
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35082061
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35057377
42	TCF4_23295773_ChIP-Seq_U87_Human	1.32076318
43	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.30681206
44	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.30681206
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30287129
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30287129
47	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.29808256
48	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.26001253
49	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.25668055
50	HTT_18923047_ChIP-ChIP_STHdh_Human	1.25565565
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24257259
52	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.23655699
53	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.23613820
54	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.23326816
55	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21357359
56	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.20249984
57	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19634860
58	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.16731981
59	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15806277
60	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.15406828
61	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.15324523
62	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.14352443
63	AR_25329375_ChIP-Seq_VCAP_Human	1.14178848
64	AR_21572438_ChIP-Seq_LNCaP_Human	1.14057076
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13645941
66	TP53_18474530_ChIP-ChIP_U2OS_Human	1.12988699
67	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12962628
68	AHR_22903824_ChIP-Seq_MCF-7_Human	1.10878106
69	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.10445339
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10215502
71	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08658900
72	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.07277720
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05043956
74	TBL1_22424771_ChIP-Seq_293T_Human	1.04941627
75	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04594548
76	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03799920
77	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.02539953
78	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.01995911
79	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.99893566
80	KDM2B_26808549_Chip-Seq_REH_Human	0.99265754
81	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.98413140
82	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.97446257
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97067056
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97067056
85	NCOR_22424771_ChIP-Seq_293T_Human	0.96359663
86	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96260096
87	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.95923743
88	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95721798
89	NFYA_21822215_ChIP-Seq_K562_Human	0.95698822
90	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95109080
91	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94537130
92	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.94302138
93	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.94167807
94	SOX2_19829295_ChIP-Seq_ESCs_Human	0.93420203
95	NANOG_19829295_ChIP-Seq_ESCs_Human	0.93420203
96	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.93230051
97	CBP_20019798_ChIP-Seq_JUKART_Human	0.93230051
98	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.92486647
99	PHF8_20622853_ChIP-Seq_HELA_Human	0.91483438
100	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.91217516

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005645_abnormal_hypothalamus_physiol	3.89073954
2	MP0002102_abnormal_ear_morphology	3.44495171
3	MP0001485_abnormal_pinna_reflex	3.24079701
4	MP0005377_hearing/vestibular/ear_phenot	3.01866184
5	MP0003878_abnormal_ear_physiology	3.01866184
6	MP0001666_abnormal_nutrient_absorption	2.72119772
7	MP0002653_abnormal_ependyma_morphology	2.58706887
8	MP0005551_abnormal_eye_electrophysiolog	2.48754645
9	MP0001486_abnormal_startle_reflex	2.41455625
10	MP0009745_abnormal_behavioral_response	2.37508977
11	MP0005646_abnormal_pituitary_gland	2.33986446
12	MP0005670_abnormal_white_adipose	2.30578639
13	MP0003045_fibrosis	2.25333035
14	MP0003880_abnormal_central_pattern	2.24702968
15	MP0002064_seizures	2.09010431
16	MP0003879_abnormal_hair_cell	2.08370768
17	MP0003283_abnormal_digestive_organ	2.02703122
18	MP0005365_abnormal_bile_salt	2.01327927
19	MP0003959_abnormal_lean_body	2.01251603
20	MP0005671_abnormal_response_to	1.99195554
21	MP0003195_calcinosis	1.99032232
22	MP0002272_abnormal_nervous_system	1.95934665
23	MP0003136_yellow_coat_color	1.92281308
24	MP0003868_abnormal_feces_composition	1.90835824
25	MP0005423_abnormal_somatic_nervous	1.84401512
26	MP0002837_dystrophic_cardiac_calcinosis	1.78150879
27	MP0003635_abnormal_synaptic_transmissio	1.72747790
28	MP0001501_abnormal_sleep_pattern	1.67275096
29	MP0002735_abnormal_chemical_nociception	1.64244001
30	MP0003646_muscle_fatigue	1.64096272
31	MP0004885_abnormal_endolymph	1.61257249
32	MP0003950_abnormal_plasma_membrane	1.58166806
33	MP0002734_abnormal_mechanical_nocicepti	1.54422567
34	MP0000569_abnormal_digit_pigmentation	1.51027228
35	MP0004270_analgesia	1.50696220
36	MP0005379_endocrine/exocrine_gland_phen	1.50284202
37	MP0002928_abnormal_bile_duct	1.49496373
38	MP0002638_abnormal_pupillary_reflex	1.44818546
39	MP0002572_abnormal_emotion/affect_behav	1.44631269
40	MP0001968_abnormal_touch/_nociception	1.43665595
41	MP0009046_muscle_twitch	1.38472738
42	MP0004130_abnormal_muscle_cell	1.36744275
43	MP0002733_abnormal_thermal_nociception	1.35737100
44	MP0000026_abnormal_inner_ear	1.35081865
45	MP0001440_abnormal_grooming_behavior	1.31656316
46	MP0001963_abnormal_hearing_physiology	1.31218567
47	MP0008875_abnormal_xenobiotic_pharmacok	1.30869453
48	MP0002063_abnormal_learning/memory/cond	1.29426025
49	MP0001970_abnormal_pain_threshold	1.29352295
50	MP0002909_abnormal_adrenal_gland	1.26958058
51	MP0008961_abnormal_basal_metabolism	1.26894245
52	MP0004147_increased_porphyrin_level	1.24282882
53	MP0004859_abnormal_synaptic_plasticity	1.23922328
54	MP0000383_abnormal_hair_follicle	1.23617912
55	MP0004742_abnormal_vestibular_system	1.20241335
56	MP0001986_abnormal_taste_sensitivity	1.19852067
57	MP0003137_abnormal_impulse_conducting	1.19283812
58	MP0002067_abnormal_sensory_capabilities	1.18374983
59	MP0005410_abnormal_fertilization	1.13439195
60	MP0003787_abnormal_imprinting	1.11678456
61	MP0002751_abnormal_autonomic_nervous	1.09797576
62	MP0004142_abnormal_muscle_tone	1.09382016
63	MP0000372_irregular_coat_pigmentation	1.05558665
64	MP0000778_abnormal_nervous_system	1.03794074
65	MP0002163_abnormal_gland_morphology	1.02399661
66	MP0005448_abnormal_energy_balance	1.01076674
67	MP0008872_abnormal_physiological_respon	0.95779958
68	MP0003690_abnormal_glial_cell	0.93891814
69	MP0008569_lethality_at_weaning	0.87984031
70	MP0004215_abnormal_myocardial_fiber	0.87811344
71	MP0002557_abnormal_social/conspecific_i	0.86994336
72	MP0006276_abnormal_autonomic_nervous	0.86974431
73	MP0003698_abnormal_male_reproductive	0.86877599
74	MP0002229_neurodegeneration	0.86223238
75	MP0003866_abnormal_defecation	0.85643983
76	MP0000566_synostosis	0.84230750
77	MP0004043_abnormal_pH_regulation	0.82775796
78	MP0002736_abnormal_nociception_after	0.82669464
79	MP0002882_abnormal_neuron_morphology	0.82459893
80	MP0000631_abnormal_neuroendocrine_gland	0.79817324
81	MP0002693_abnormal_pancreas_physiology	0.76793067
82	MP0004145_abnormal_muscle_electrophysio	0.76137384
83	MP0002168_other_aberrant_phenotype	0.75417363
84	MP0004085_abnormal_heartbeat	0.74349043
85	MP0003953_abnormal_hormone_level	0.72460394
86	MP0002066_abnormal_motor_capabilities/c	0.71402322
87	MP0010386_abnormal_urinary_bladder	0.70610849
88	MP0001765_abnormal_ion_homeostasis	0.70423196
89	MP0000955_abnormal_spinal_cord	0.69375884
90	MP0002876_abnormal_thyroid_physiology	0.69351085
91	MP0002752_abnormal_somatic_nervous	0.68512508
92	MP0010368_abnormal_lymphatic_system	0.68451636
93	MP0001661_extended_life_span	0.67769000
94	MP0003632_abnormal_nervous_system	0.67650867
95	MP0000003_abnormal_adipose_tissue	0.67611761
96	MP0002078_abnormal_glucose_homeostasis	0.67457807
97	MP0001929_abnormal_gametogenesis	0.66920817
98	MP0005332_abnormal_amino_acid	0.66146680
99	MP0008877_abnormal_DNA_methylation	0.66088477
100	MP0003119_abnormal_digestive_system	0.65950027

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.92786082
2	Congenital stationary night blindness (HP:0007642)	4.07452065
3	True hermaphroditism (HP:0010459)	3.84888283
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.72587338
5	Absent/shortened dynein arms (HP:0200106)	3.72587338
6	Tinnitus (HP:0000360)	3.60672245
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.52795698
8	Pancreatic fibrosis (HP:0100732)	3.50424533
9	Hyperventilation (HP:0002883)	3.41811358
10	Cerebellar dysplasia (HP:0007033)	3.39982573
11	Cystic liver disease (HP:0006706)	3.37050929
12	Febrile seizures (HP:0002373)	3.29176630
13	Nephronophthisis (HP:0000090)	3.25999244
14	Progressive cerebellar ataxia (HP:0002073)	3.21033095
15	Focal motor seizures (HP:0011153)	3.02788801
16	Gaze-evoked nystagmus (HP:0000640)	2.97285118
17	Abnormality of alanine metabolism (HP:0010916)	2.95576309
18	Hyperalaninemia (HP:0003348)	2.95576309
19	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.95576309
20	Abnormal rod and cone electroretinograms (HP:0008323)	2.95328646
21	Steatorrhea (HP:0002570)	2.94446769
22	Focal seizures (HP:0007359)	2.83073708
23	Genetic anticipation (HP:0003743)	2.80594403
24	Abnormality of the renal medulla (HP:0100957)	2.80184412
25	Ventricular fibrillation (HP:0001663)	2.77754354
26	Occipital encephalocele (HP:0002085)	2.76553219
27	Attenuation of retinal blood vessels (HP:0007843)	2.76411215
28	Azoospermia (HP:0000027)	2.75335098
29	Tubular atrophy (HP:0000092)	2.70967209
30	Concave nail (HP:0001598)	2.70009613
31	Abnormality of the renal cortex (HP:0011035)	2.64649524
32	Sclerocornea (HP:0000647)	2.64602859
33	Chronic hepatic failure (HP:0100626)	2.61235983
34	Congenital sensorineural hearing impairment (HP:0008527)	2.61166241
35	Molar tooth sign on MRI (HP:0002419)	2.59120489
36	Abnormality of midbrain morphology (HP:0002418)	2.59120489
37	Hypothermia (HP:0002045)	2.58348764
38	Generalized aminoaciduria (HP:0002909)	2.55956266
39	Abnormal drinking behavior (HP:0030082)	2.55448240
40	Polydipsia (HP:0001959)	2.55448240
41	Acute necrotizing encephalopathy (HP:0006965)	2.51020921
42	Atonic seizures (HP:0010819)	2.46776214
43	Prolonged QT interval (HP:0001657)	2.45188142
44	Primary atrial arrhythmia (HP:0001692)	2.44042158
45	Long nose (HP:0003189)	2.41494013
46	Atrial fibrillation (HP:0005110)	2.41077659
47	Inability to walk (HP:0002540)	2.37838765
48	Hemiplegia (HP:0002301)	2.37327619
49	Large for gestational age (HP:0001520)	2.30951130
50	Broad-based gait (HP:0002136)	2.30848598
51	Hypoproteinemia (HP:0003075)	2.30544295
52	Clumsiness (HP:0002312)	2.28491909
53	Acute encephalopathy (HP:0006846)	2.27192359
54	Retinal atrophy (HP:0001105)	2.26633439
55	Congenital, generalized hypertrichosis (HP:0004540)	2.25206531
56	Amelogenesis imperfecta (HP:0000705)	2.24879893
57	Furrowed tongue (HP:0000221)	2.24381584
58	Type II lissencephaly (HP:0007260)	2.22637684
59	Myokymia (HP:0002411)	2.21827164
60	Mitochondrial inheritance (HP:0001427)	2.21744116
61	Enlarged epiphyses (HP:0010580)	2.21095870
62	Bilateral sensorineural hearing impairment (HP:0008619)	2.20491440
63	Supraventricular tachycardia (HP:0004755)	2.17896591
64	Abnormal number of erythroid precursors (HP:0012131)	2.16666151
65	Nonprogressive disorder (HP:0003680)	2.16653741
66	Syncope (HP:0001279)	2.14457259
67	Abnormal spermatogenesis (HP:0008669)	2.13603678
68	Hemiparesis (HP:0001269)	2.12855292
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.11239095
70	Fat malabsorption (HP:0002630)	2.10115034
71	Supraventricular arrhythmia (HP:0005115)	2.08120642
72	Bulbous nose (HP:0000414)	2.07732293
73	Anencephaly (HP:0002323)	2.07256901
74	Severe muscular hypotonia (HP:0006829)	2.07213015
75	Epileptic encephalopathy (HP:0200134)	2.04885344
76	Polyuria (HP:0000103)	2.03939581
77	Abnormal respiratory epithelium morphology (HP:0012253)	2.03792238
78	Abnormal respiratory motile cilium morphology (HP:0005938)	2.03792238
79	Abnormal ciliary motility (HP:0012262)	1.97496454
80	Hypomagnesemia (HP:0002917)	1.96937424
81	Abnormal mitochondria in muscle tissue (HP:0008316)	1.96551570
82	Status epilepticus (HP:0002133)	1.96039483
83	Progressive macrocephaly (HP:0004481)	1.94529141
84	Pigmentary retinal degeneration (HP:0001146)	1.91401840
85	Sudden death (HP:0001699)	1.90169836
86	Decreased central vision (HP:0007663)	1.88906940
87	Pheochromocytoma (HP:0002666)	1.88579558
88	Chorioretinal atrophy (HP:0000533)	1.88021288
89	Congenital hepatic fibrosis (HP:0002612)	1.87394322
90	Abnormal EKG (HP:0003115)	1.82190517
91	Severe combined immunodeficiency (HP:0004430)	1.81968463
92	Tubulointerstitial fibrosis (HP:0005576)	1.80135536
93	Morphological abnormality of the inner ear (HP:0011390)	1.80083752
94	Portal hypertension (HP:0001409)	1.78970730
95	Aplastic anemia (HP:0001915)	1.78089345
96	Medial flaring of the eyebrow (HP:0010747)	1.77269867
97	Abnormal urine output (HP:0012590)	1.76454469
98	Increased CSF lactate (HP:0002490)	1.75360011
99	Hepatocellular necrosis (HP:0001404)	1.75096910
100	Flat occiput (HP:0005469)	1.74821799

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.79953710
2	SIK2	4.54685695
3	FRK	3.73451763
4	KDR	3.18455069
5	PLK4	2.70742712
6	ADRBK2	2.69703486
7	TYRO3	2.66417047
8	MAPK15	2.25725548
9	STK16	2.20155127
10	GRK1	2.16604612
11	BLK	1.90243571
12	INSRR	1.86395781
13	NTRK3	1.80983145
14	TNIK	1.78083944
15	PASK	1.74467119
16	ZAK	1.65213605
17	CAMK1D	1.58340602
18	LMTK2	1.56137739
19	MARK1	1.54125036
20	CAMK1G	1.45351520
21	BMPR1B	1.42811258
22	PTK2B	1.40428337
23	NTRK2	1.40055825
24	ACVR1B	1.35334793
25	MAP3K13	1.35082768
26	WNK4	1.28341838
27	MAP3K4	1.26364308
28	NEK2	1.18892420
29	ZAP70	1.10629525
30	MAP2K7	1.08506643
31	MAP3K11	1.07001777
32	DAPK2	1.06571635
33	ADRBK1	1.05740037
34	STK38	1.04782533
35	TLK1	1.04320486
36	OBSCN	1.01441735
37	NME1	1.00509675
38	TIE1	0.97447785
39	RIPK4	0.93136652
40	PINK1	0.91480266
41	ITK	0.90074937
42	MAP4K2	0.90012972
43	MUSK	0.89477001
44	LIMK1	0.88955260
45	MAPK13	0.86751548
46	PRKCQ	0.85778707
47	CDK19	0.81970059
48	TXK	0.80480338
49	WNK3	0.79636495
50	SYK	0.77582186
51	CASK	0.76323378
52	NUAK1	0.73368117
53	UHMK1	0.70921198
54	CAMK2A	0.69980994
55	PIK3CA	0.69200434
56	NEK9	0.68587464
57	PRKCG	0.66199077
58	LATS1	0.66130748
59	TESK2	0.65633973
60	DDR2	0.64841538
61	PAK6	0.64723640
62	MAP3K7	0.63376356
63	MAP4K1	0.61912014
64	PRKCI	0.60883872
65	SCYL2	0.60119125
66	RPS6KA5	0.59525949
67	PDK1	0.59186526
68	WNK1	0.57904729
69	MARK3	0.57561089
70	PRKCH	0.55563328
71	OXSR1	0.53805544
72	BRD4	0.51521570
73	STK11	0.51457309
74	SGK223	0.51113076
75	SGK494	0.51113076
76	SGK2	0.50959448
77	CAMK4	0.50021426
78	CAMK1	0.49534687
79	BMX	0.47801713
80	MAP2K4	0.47248885
81	RPS6KA6	0.46390388
82	PRKCE	0.45738619
83	PRKG1	0.45268460
84	CSK	0.44369185
85	CAMK2B	0.44028152
86	MAP2K1	0.42563717
87	CAMKK1	0.42384739
88	PHKG1	0.42273211
89	PHKG2	0.42273211
90	MET	0.40611861
91	STK38L	0.40598204
92	MAP3K5	0.38273469
93	CSNK1D	0.37857515
94	PRKCZ	0.37460861
95	PRKACA	0.36090417
96	VRK1	0.35426533
97	CSNK1A1	0.35021196
98	PRKCB	0.33042119
99	PDPK1	0.32890923
100	RPS6KA3	0.31632125

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pancreatic secretion_Homo sapiens_hsa04972	5.08331567
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.08360329
3	Linoleic acid metabolism_Homo sapiens_hsa00591	3.92099551
4	Fat digestion and absorption_Homo sapiens_hsa04975	3.56813995
5	Phototransduction_Homo sapiens_hsa04744	2.87895085
6	Protein digestion and absorption_Homo sapiens_hsa04974	2.66869468
7	Ether lipid metabolism_Homo sapiens_hsa00565	2.32899813
8	Nicotine addiction_Homo sapiens_hsa05033	2.30577882
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.05206237
10	Glycerolipid metabolism_Homo sapiens_hsa00561	1.89620299
11	Histidine metabolism_Homo sapiens_hsa00340	1.85406197
12	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.77494568
13	Primary immunodeficiency_Homo sapiens_hsa05340	1.77082107
14	Taste transduction_Homo sapiens_hsa04742	1.76423485
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.68914320
16	Glutamatergic synapse_Homo sapiens_hsa04724	1.61790804
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.59711700
18	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.59396324
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.54524639
20	Olfactory transduction_Homo sapiens_hsa04740	1.46672486
21	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.45475841
22	Serotonergic synapse_Homo sapiens_hsa04726	1.45284447
23	Circadian entrainment_Homo sapiens_hsa04713	1.44345553
24	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.37609976
25	Morphine addiction_Homo sapiens_hsa05032	1.36896981
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.32638107
27	Insulin secretion_Homo sapiens_hsa04911	1.30951306
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.29629175
29	Calcium signaling pathway_Homo sapiens_hsa04020	1.26749955
30	Butanoate metabolism_Homo sapiens_hsa00650	1.26357079
31	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.22519235
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.19140808
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.14928402
34	Cocaine addiction_Homo sapiens_hsa05030	1.13866687
35	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.05512940
36	Bile secretion_Homo sapiens_hsa04976	1.03123112
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.02186818
38	ABC transporters_Homo sapiens_hsa02010	1.00353825
39	Mineral absorption_Homo sapiens_hsa04978	0.99642868
40	Gastric acid secretion_Homo sapiens_hsa04971	0.96896912
41	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.95974876
42	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.92808595
43	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.92492504
44	Tryptophan metabolism_Homo sapiens_hsa00380	0.91352794
45	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.90955336
46	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.88809410
47	Salivary secretion_Homo sapiens_hsa04970	0.87967003
48	Parkinsons disease_Homo sapiens_hsa05012	0.87277955
49	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.86633952
50	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.83540937
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83282901
52	GABAergic synapse_Homo sapiens_hsa04727	0.83090950
53	MAPK signaling pathway_Homo sapiens_hsa04010	0.82439910
54	Long-term depression_Homo sapiens_hsa04730	0.80642722
55	Amphetamine addiction_Homo sapiens_hsa05031	0.79724112
56	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.77633758
57	cAMP signaling pathway_Homo sapiens_hsa04024	0.76200617
58	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.74854290
59	Alzheimers disease_Homo sapiens_hsa05010	0.73898030
60	Oxidative phosphorylation_Homo sapiens_hsa00190	0.72604426
61	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.71922199
62	Ras signaling pathway_Homo sapiens_hsa04014	0.71240674
63	Renin secretion_Homo sapiens_hsa04924	0.68996317
64	Huntingtons disease_Homo sapiens_hsa05016	0.64910721
65	Dopaminergic synapse_Homo sapiens_hsa04728	0.61752678
66	Cholinergic synapse_Homo sapiens_hsa04725	0.59784486
67	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.57569950
68	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.56948516
69	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.55944150
70	Sulfur metabolism_Homo sapiens_hsa00920	0.53917548
71	Type II diabetes mellitus_Homo sapiens_hsa04930	0.51352540
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.49267900
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46284226
74	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.44039179
75	Ribosome_Homo sapiens_hsa03010	0.42474394
76	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.41513888
77	Propanoate metabolism_Homo sapiens_hsa00640	0.40859751
78	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.40108015
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.37711455
80	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.36641968
81	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.35705890
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.34399936
83	Basal transcription factors_Homo sapiens_hsa03022	0.33306131
84	Retinol metabolism_Homo sapiens_hsa00830	0.32622682
85	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.32379182
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.32010641
87	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.31720798
88	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.31522549
89	Circadian rhythm_Homo sapiens_hsa04710	0.30177498
90	Renin-angiotensin system_Homo sapiens_hsa04614	0.30123346
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.28794100
92	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.28274534
93	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.27432277
94	VEGF signaling pathway_Homo sapiens_hsa04370	0.27357324
95	Caffeine metabolism_Homo sapiens_hsa00232	0.27262747
96	Chemical carcinogenesis_Homo sapiens_hsa05204	0.27014294
97	Sulfur relay system_Homo sapiens_hsa04122	0.26855871
98	GnRH signaling pathway_Homo sapiens_hsa04912	0.25149467
99	Rap1 signaling pathway_Homo sapiens_hsa04015	0.23766609
100	Axon guidance_Homo sapiens_hsa04360	0.22747834

USP17L23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »