USP17L6P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to vitamin A (GO:0033189)9.86790940
2cellular response to epidermal growth factor stimulus (GO:0071364)8.41375023
3O-glycan processing (GO:0016266)8.15460959
4regulation of ARF GTPase activity (GO:0032312)6.59197931
5response to epidermal growth factor (GO:0070849)6.44809374
6C21-steroid hormone biosynthetic process (GO:0006700)6.40030768
7nephron tubule morphogenesis (GO:0072078)6.39755110
8nephron epithelium morphogenesis (GO:0072088)6.39755110
9establishment of protein localization to Golgi (GO:0072600)5.90885974
10protein targeting to Golgi (GO:0000042)5.87709213
11retrograde transport, vesicle recycling within Golgi (GO:0000301)5.49725743
12protein O-linked glycosylation (GO:0006493)5.49206888
13negative regulation of digestive system process (GO:0060457)5.35597773
14phosphate ion homeostasis (GO:0055062)5.24974015
15trivalent inorganic anion homeostasis (GO:0072506)5.24974015
16renal tubule morphogenesis (GO:0061333)4.98846562
17L-fucose catabolic process (GO:0042355)4.86679180
18fucose catabolic process (GO:0019317)4.86679180
19L-fucose metabolic process (GO:0042354)4.86679180
20glucocorticoid biosynthetic process (GO:0006704)4.81487836
21cellular response to glucocorticoid stimulus (GO:0071385)4.78411846
22regulation of acrosome reaction (GO:0060046)4.56929696
23cellular anion homeostasis (GO:0030002)4.55583173
24protein localization to Golgi apparatus (GO:0034067)4.53152427
25cellular response to corticosteroid stimulus (GO:0071384)4.43988020
26digestive system process (GO:0022600)4.36197357
27membrane depolarization during action potential (GO:0086010)4.33162125
28auditory receptor cell stereocilium organization (GO:0060088)4.29261684
29renal absorption (GO:0070293)4.22280361
30Arp2/3 complex-mediated actin nucleation (GO:0034314)4.19081938
31vocalization behavior (GO:0071625)4.05618088
32actin filament capping (GO:0051693)4.00620256
33positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.99374827
34actin nucleation (GO:0045010)3.97096934
35fucosylation (GO:0036065)3.95451113
36striated muscle atrophy (GO:0014891)3.85318329
37bundle of His cell to Purkinje myocyte communication (GO:0086069)3.78547778
38phosphate ion transmembrane transport (GO:0035435)3.77098369
39regulation of RIG-I signaling pathway (GO:0039535)3.74740290
40creatine metabolic process (GO:0006600)3.70028820
41muscle atrophy (GO:0014889)3.61893830
42skeletal muscle adaptation (GO:0043501)3.54430485
43phosphate ion transport (GO:0006817)3.46735477
44negative regulation of actin filament depolymerization (GO:0030835)3.45721495
45myoblast fusion (GO:0007520)3.37767159
46extracellular fibril organization (GO:0043206)3.31572390
47photoreceptor cell maintenance (GO:0045494)3.29992087
48cilium or flagellum-dependent cell motility (GO:0001539)3.22726603
49cellular response to retinoic acid (GO:0071300)3.18945711
50membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.18849474
51positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.18425960
52inner ear receptor stereocilium organization (GO:0060122)3.16707281
53dendritic spine morphogenesis (GO:0060997)3.12597915
54ketone biosynthetic process (GO:0042181)3.10914237
55dendritic spine organization (GO:0097061)3.05261365
56regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.04508692
57fibril organization (GO:0097435)3.03945360
58collecting duct development (GO:0072044)3.02968702
59GDP-mannose metabolic process (GO:0019673)3.02907444
60calcium ion import (GO:0070509)3.02835276
61neuronal action potential (GO:0019228)3.01377673
62establishment of skin barrier (GO:0061436)2.99687382
63syncytium formation by plasma membrane fusion (GO:0000768)2.95933287
64inner ear receptor cell differentiation (GO:0060113)2.94966317
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.92082326
66C21-steroid hormone metabolic process (GO:0008207)2.90149374
67regulation of podosome assembly (GO:0071801)2.87870391
68cardiovascular system development (GO:0072358)2.85386830
69intestinal cholesterol absorption (GO:0030299)2.84655569
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84567644
71negative regulation of actin filament polymerization (GO:0030837)2.82965947
72growth hormone secretion (GO:0030252)2.82513540
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76375449
74syncytium formation (GO:0006949)2.74772406
75hair cell differentiation (GO:0035315)2.74287473
76membrane repolarization during action potential (GO:0086011)2.73431097
77epithelial cell fate commitment (GO:0072148)2.72583512
78macroautophagy (GO:0016236)2.68868953
79regulation of cholesterol homeostasis (GO:2000188)2.64325835
80positive regulation of sodium ion transmembrane transport (GO:1902307)2.61937198
81anatomical structure regression (GO:0060033)2.61199295
82urogenital system development (GO:0001655)2.59973527
83regulation of actin filament depolymerization (GO:0030834)2.59790883
84multicellular organism reproduction (GO:0032504)2.58060706
85glucocorticoid metabolic process (GO:0008211)2.57391010
86regulation of water loss via skin (GO:0033561)2.56410001
87negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.54963539
88inositol metabolic process (GO:0006020)2.53806268
89regulation of digestive system process (GO:0044058)2.53320613
90detection of mechanical stimulus (GO:0050982)2.53073020
91termination of G-protein coupled receptor signaling pathway (GO:0038032)2.48350651
92positive regulation of digestive system process (GO:0060456)2.48305050
93brain morphogenesis (GO:0048854)2.43550566
94glomerular basement membrane development (GO:0032836)2.42639864
95positive regulation of CREB transcription factor activity (GO:0032793)2.39686609
96auditory receptor cell differentiation (GO:0042491)2.38490111
97calcium ion transmembrane transport (GO:0070588)2.36585248
98regulation of G0 to G1 transition (GO:0070316)15.3399813
99maintenance of gastrointestinal epithelium (GO:0030277)15.2070935
100epithelial structure maintenance (GO:0010669)11.0262487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human6.45543260
2DROSHA_22980978_ChIP-Seq_HELA_Human4.61325405
3EZH2_22144423_ChIP-Seq_EOC_Human4.35405834
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.28053403
5VDR_22108803_ChIP-Seq_LS180_Human3.24263297
6GBX2_23144817_ChIP-Seq_PC3_Human3.18756050
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.17201572
8WDR5_24793694_ChIP-Seq_LNCAP_Human2.73166050
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.34186169
10CDX2_20551321_ChIP-Seq_CACO-2_Human2.03482506
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01388352
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.99217935
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98637827
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95598468
15BCAT_22108803_ChIP-Seq_LS180_Human1.89885004
16ER_23166858_ChIP-Seq_MCF-7_Human1.87039461
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.74188391
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68312549
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66486531
20ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65580371
21SMC4_20622854_ChIP-Seq_HELA_Human1.54295176
22TCF4_18268006_ChIP-ChIP_LS174T_Human1.46499399
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45028740
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42876511
25OCT4_20526341_ChIP-Seq_ESCs_Human1.41224869
26NFYA_21822215_ChIP-Seq_K562_Human1.39921236
27CTCF_27219007_Chip-Seq_Bcells_Human1.39505427
28AR_21572438_ChIP-Seq_LNCaP_Human1.38532800
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37403590
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.37308994
31SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34478863
32TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.32251243
33GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30114505
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29785611
35CDX2_22108803_ChIP-Seq_LS180_Human1.26812671
36RUNX1_27514584_Chip-Seq_MCF-7_Human1.24452333
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23621302
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21810821
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21686580
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.20322767
41BCL6_27268052_Chip-Seq_Bcells_Human1.20059602
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16581990
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.15801238
44CTCF_20526341_ChIP-Seq_ESCs_Human1.15794659
45TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14679604
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14647104
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13372314
48SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13143532
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11922653
50TBL1_22424771_ChIP-Seq_293T_Human1.11496494
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.11170210
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11077655
53KLF5_25053715_ChIP-Seq_YYC3_Human1.10966951
54* E2F1_20622854_ChIP-Seq_HELA_Human1.10555477
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09017293
56AR_25329375_ChIP-Seq_VCAP_Human1.07982339
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07946928
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07194542
59TCF4_23295773_ChIP-Seq_U87_Human1.06726040
60CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06716226
61TP53_22573176_ChIP-Seq_HFKS_Human1.06012084
62STAT3_23295773_ChIP-Seq_U87_Human1.05933045
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.04625370
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04098772
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02663846
66AHR_22903824_ChIP-Seq_MCF-7_Human1.01884552
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01465115
68CBP_20019798_ChIP-Seq_JUKART_Human1.01465115
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00228727
70SPI1_23127762_ChIP-Seq_K562_Human0.99982868
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99417138
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99368680
73IRF8_22096565_ChIP-ChIP_GC-B_Human0.97969441
74NFYB_21822215_ChIP-Seq_K562_Human0.97042435
75RUNX2_22187159_ChIP-Seq_PCA_Human0.96934141
76NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96543694
77OCT1_27270436_Chip-Seq_PROSTATE_Human0.96091975
78MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95950227
79TCF4_22108803_ChIP-Seq_LS180_Human0.95682037
80EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95603626
81RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95603626
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94850723
83TP63_22573176_ChIP-Seq_HFKS_Human0.94071298
84EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93407539
85SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92411636
86MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91512666
87E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90458988
88AR_20517297_ChIP-Seq_VCAP_Human0.89945093
89RNF2_27304074_Chip-Seq_ESCs_Mouse0.89482890
90PRDM14_20953172_ChIP-Seq_ESCs_Human0.89372760
91TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.89094048
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88934457
93JARID2_20064375_ChIP-Seq_MESCs_Mouse0.88345609
94BCOR_27268052_Chip-Seq_Bcells_Human0.88320590
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88000084
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88000084
97P68_20966046_ChIP-Seq_HELA_Human0.87782617
98AR_19668381_ChIP-Seq_PC3_Human0.87645527
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87410763
100TAF2_19829295_ChIP-Seq_ESCs_Human0.86562841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000465_gastrointestinal_hemorrhage5.58753072
2MP0000579_abnormal_nail_morphology4.93701505
3MP0004043_abnormal_pH_regulation4.67325058
4MP0003879_abnormal_hair_cell4.60143873
5MP0000566_synostosis4.35523787
6MP0005377_hearing/vestibular/ear_phenot3.40079615
7MP0003878_abnormal_ear_physiology3.40079615
8MP0003866_abnormal_defecation3.29454122
9MP0005275_abnormal_skin_tensile3.27779529
10MP0001485_abnormal_pinna_reflex3.11968570
11MP0002822_catalepsy3.08964765
12MP0001666_abnormal_nutrient_absorption2.88838140
13MP0008438_abnormal_cutaneous_collagen2.64282496
14MP0003705_abnormal_hypodermis_morpholog2.45784068
15MP0003252_abnormal_bile_duct2.17846298
16MP0001765_abnormal_ion_homeostasis2.14457686
17MP0002102_abnormal_ear_morphology2.14086409
18MP0008004_abnormal_stomach_pH2.10206973
19MP0001664_abnormal_digestion1.87667950
20MP0008995_early_reproductive_senescence1.82858802
21MP0002138_abnormal_hepatobiliary_system1.80482133
22MP0001661_extended_life_span1.80038891
23MP0005551_abnormal_eye_electrophysiolog1.71196072
24MP0001963_abnormal_hearing_physiology1.59667159
25MP0002060_abnormal_skin_morphology1.57954917
26MP0000026_abnormal_inner_ear1.57474773
27MP0004742_abnormal_vestibular_system1.54616309
28MP0005257_abnormal_intraocular_pressure1.53806268
29MP0002098_abnormal_vibrissa_morphology1.52407130
30MP0003091_abnormal_cell_migration1.50623414
31MP0000751_myopathy1.43146425
32MP0000427_abnormal_hair_cycle1.42708176
33MP0001663_abnormal_digestive_system1.41589355
34MP0005381_digestive/alimentary_phenotyp1.35983644
35MP0004019_abnormal_vitamin_homeostasis1.33496042
36MP0003646_muscle_fatigue1.31351182
37MP0000647_abnormal_sebaceous_gland1.31002707
38MP0001243_abnormal_dermal_layer1.30579600
39MP0005083_abnormal_biliary_tract1.28767253
40MP0000749_muscle_degeneration1.26882724
41MP0002735_abnormal_chemical_nociception1.25730571
42MP0000383_abnormal_hair_follicle1.24582695
43MP0010155_abnormal_intestine_physiology1.23567607
44MP0010386_abnormal_urinary_bladder1.15941255
45MP0003195_calcinosis1.13091990
46MP0010234_abnormal_vibrissa_follicle1.11908541
47MP0002928_abnormal_bile_duct1.09989308
48MP0003279_aneurysm1.09691936
49MP0003045_fibrosis1.09560475
50MP0000538_abnormal_urinary_bladder1.07266653
51MP0002229_neurodegeneration1.05730890
52MP0010678_abnormal_skin_adnexa1.01689824
53MP0002272_abnormal_nervous_system0.99814627
54MP0002896_abnormal_bone_mineralization0.94329223
55MP0002733_abnormal_thermal_nociception0.93522580
56MP0002269_muscular_atrophy0.90089832
57MP0004145_abnormal_muscle_electrophysio0.89940229
58MP0001542_abnormal_bone_strength0.88645740
59MP0001986_abnormal_taste_sensitivity0.87780213
60MP0009046_muscle_twitch0.81619826
61MP0005187_abnormal_penis_morphology0.80643675
62MP0010771_integument_phenotype0.80487874
63MP0003950_abnormal_plasma_membrane0.79661269
64MP0002067_abnormal_sensory_capabilities0.79314668
65MP0001968_abnormal_touch/_nociception0.78495227
66MP0005410_abnormal_fertilization0.78359366
67MP0004036_abnormal_muscle_relaxation0.78218257
68MP0000462_abnormal_digestive_system0.77475944
69MP0005503_abnormal_tendon_morphology0.75570614
70MP0001486_abnormal_startle_reflex0.72718815
71MP0010030_abnormal_orbit_morphology0.72460601
72MP0003283_abnormal_digestive_organ0.71054339
73MP0002736_abnormal_nociception_after0.68710876
74MP0003763_abnormal_thymus_physiology0.68421711
75MP0004147_increased_porphyrin_level0.66326357
76MP0000747_muscle_weakness0.66230423
77MP0001970_abnormal_pain_threshold0.65627957
78MP0002249_abnormal_larynx_morphology0.65619015
79MP0003786_premature_aging0.65040308
80MP0002160_abnormal_reproductive_system0.64996897
81MP0005253_abnormal_eye_physiology0.63560600
82MP0002136_abnormal_kidney_physiology0.62268060
83MP0002752_abnormal_somatic_nervous0.61895281
84MP0001324_abnormal_eye_pigmentation0.61185337
85MP0002127_abnormal_cardiovascular_syste0.61065939
86MP0002210_abnormal_sex_determination0.60707552
87MP0004924_abnormal_behavior0.60663461
88MP0005386_behavior/neurological_phenoty0.60663461
89MP0005670_abnormal_white_adipose0.59478522
90MP0001756_abnormal_urination0.58500446
91MP0005636_abnormal_mineral_homeostasis0.58334587
92MP0001270_distended_abdomen0.57577530
93MP0004272_abnormal_basement_membrane0.56809625
94MP0002332_abnormal_exercise_endurance0.56168424
95MP0000477_abnormal_intestine_morphology0.55992897
96MP0002095_abnormal_skin_pigmentation0.53808647
97MP0005645_abnormal_hypothalamus_physiol0.53721277
98MP0000230_abnormal_systemic_arterial0.53399672
99MP0005076_abnormal_cell_differentiation0.49107463
100MP0005508_abnormal_skeleton_morphology0.47588733

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)6.50600170
2Pili torti (HP:0003777)6.24986466
3Congenital sensorineural hearing impairment (HP:0008527)5.25546661
4Mask-like facies (HP:0000298)5.23581060
5Thin bony cortex (HP:0002753)5.18854903
6Enlarged epiphyses (HP:0010580)5.06452641
7Hyperkalemia (HP:0002153)4.79840171
8Hypophosphatemic rickets (HP:0004912)4.59385701
9Bilateral sensorineural hearing impairment (HP:0008619)4.56822010
10Abnormality of dentin (HP:0010299)4.51939542
11Duplicated collecting system (HP:0000081)4.08042897
12Abnormal hair laboratory examination (HP:0003328)4.00306868
13Tibial bowing (HP:0002982)3.94220797
14Hemorrhage of the eye (HP:0011885)3.87686252
15Delayed epiphyseal ossification (HP:0002663)3.82130520
16Abnormality of chloride homeostasis (HP:0011422)3.80091005
17Distal lower limb amyotrophy (HP:0008944)3.70189990
18Abnormality of the renal collecting system (HP:0004742)3.56207707
19Ureteral duplication (HP:0000073)3.33273576
20Urethral obstruction (HP:0000796)3.33096033
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.26882687
22Abnormal trabecular bone morphology (HP:0100671)3.11355247
23Malnutrition (HP:0004395)3.09843244
24Cerebral aneurysm (HP:0004944)3.01957394
25Periorbital edema (HP:0100539)2.94531307
26Abnormality of the distal phalanges of the toes (HP:0010182)2.88880519
27Abnormality of pyrimidine metabolism (HP:0004353)2.88857713
28Abnormality of the costochondral junction (HP:0000919)2.87560379
29Distal upper limb amyotrophy (HP:0007149)2.84971222
30Upper limb amyotrophy (HP:0009129)2.84971222
31Mildly elevated creatine phosphokinase (HP:0008180)2.84231219
32Facial edema (HP:0000282)2.81541155
33Broad face (HP:0000283)2.78407666
34Cystic liver disease (HP:0006706)2.72052735
35Short nail (HP:0001799)2.72013662
36Abnormality of DNA repair (HP:0003254)2.71864327
37Patent foramen ovale (HP:0001655)2.70307223
38Abnormality of the 1st metacarpal (HP:0010009)2.70205505
39Nuclear cataract (HP:0100018)2.69821701
40Chromsome breakage (HP:0040012)2.67239166
41Fragile skin (HP:0001030)2.65683467
42Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.63517738
43Short 1st metacarpal (HP:0010034)2.63517738
44Duplication of thumb phalanx (HP:0009942)2.61922345
45Widely patent fontanelles and sutures (HP:0004492)2.59364035
46Increased connective tissue (HP:0009025)2.55125157
47Neonatal short-limb short stature (HP:0008921)2.50973031
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.46682880
49Axonal loss (HP:0003447)2.46217348
50Increased corneal curvature (HP:0100692)2.44576665
51Keratoconus (HP:0000563)2.44576665
52Spinal muscular atrophy (HP:0007269)2.42624216
53Lower limb amyotrophy (HP:0007210)2.38882047
54Difficulty walking (HP:0002355)2.37173785
55Pulmonary artery stenosis (HP:0004415)2.35249147
56Follicular hyperkeratosis (HP:0007502)2.29380534
57Dynein arm defect of respiratory motile cilia (HP:0012255)2.27826590
58Absent/shortened dynein arms (HP:0200106)2.27826590
59Ectopic kidney (HP:0000086)2.26557115
60Atrophic scars (HP:0001075)2.24857729
61Natal tooth (HP:0000695)2.24108852
62Neonatal respiratory distress (HP:0002643)2.22980157
63Bony spicule pigmentary retinopathy (HP:0007737)2.20718979
64Abnormality of the carotid arteries (HP:0005344)2.16749611
65Hyperactive renin-angiotensin system (HP:0000841)2.16257389
66Short phalanx of the thumb (HP:0009660)2.14845107
67Milia (HP:0001056)2.14671706
68Abnormality of the preputium (HP:0100587)2.10914604
69Bronchomalacia (HP:0002780)2.09776012
70Abnormality of potassium homeostasis (HP:0011042)2.08944689
71Broad metatarsal (HP:0001783)2.06888355
72Tongue fasciculations (HP:0001308)2.05043806
73Premature rupture of membranes (HP:0001788)2.05029180
74Femoral bowing (HP:0002980)2.04103959
75Hypergonadotropic hypogonadism (HP:0000815)2.04080566
76Congenital, generalized hypertrichosis (HP:0004540)2.03512053
77Male infertility (HP:0003251)2.00875159
78Pigmentary retinal degeneration (HP:0001146)1.98765596
79Morphological abnormality of the middle ear (HP:0008609)1.98743071
80Depressed nasal tip (HP:0000437)1.95880840
81Tubulointerstitial nephritis (HP:0001970)1.92950450
82Progressive sensorineural hearing impairment (HP:0000408)1.88710967
83Self-mutilation (HP:0000742)1.88596423
84Delayed CNS myelination (HP:0002188)1.88338923
85Muscle fibrillation (HP:0010546)1.85124881
86Spondylolisthesis (HP:0003302)1.83922233
87Aortic dissection (HP:0002647)1.83185120
88Long eyelashes (HP:0000527)1.82869837
89Clubbing of toes (HP:0100760)1.82291590
90Difficulty climbing stairs (HP:0003551)1.81727326
91Abnormality of the right ventricle (HP:0001707)1.81688544
92Flat occiput (HP:0005469)1.79512083
93Abnormality of the ileum (HP:0001549)1.78456678
94Onion bulb formation (HP:0003383)1.78213162
95Metaphyseal irregularity (HP:0003025)1.74860758
96Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74752561
97Congenital stationary night blindness (HP:0007642)1.73470839
98Progressive hearing impairment (HP:0001730)1.72610205
99Rickets (HP:0002748)1.71222262
100Meckel diverticulum (HP:0002245)1.70116333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.41011840
2MST1R8.07671492
3TESK25.20563463
4NME15.06150746
5WNK13.27280780
6MET3.12736563
7MAP3K132.07006731
8GRK11.81451872
9FRK1.81370178
10LMTK21.71908767
11MUSK1.66623273
12BLK1.63079547
13STK391.61370222
14ICK1.57120457
15CDK121.45347126
16MAP2K61.32258970
17TNIK1.17907348
18MAPKAPK31.17655598
19NEK21.12823465
20ACVR1B1.12454298
21MAP4K21.07368203
22SIK20.97569434
23MAP3K70.97283877
24ERBB20.87490518
25INSRR0.85902425
26DDR20.81758228
27MST40.78716612
28ZAK0.78263778
29TEC0.75700029
30ITK0.69799341
31TXK0.64011868
32PIK3CG0.63587096
33MAP3K90.63151716
34SIK10.60370098
35OXSR10.60173943
36TRPM70.58849600
37PHKG10.56688711
38PHKG20.56688711
39MARK20.55883079
40CAMK1D0.53227002
41SGK10.53188344
42SYK0.50984020
43KDR0.50314503
44DAPK10.45911842
45PRKCH0.43288929
46PDGFRB0.42729948
47CAMK1G0.42220320
48PAK30.41702432
49CASK0.41587596
50PASK0.39506332
51MAP3K60.36633374
52NLK0.34958268
53BTK0.33119953
54NTRK10.33053078
55CAMK2B0.32606490
56PRKAA20.32053446
57CDC42BPA0.29912154
58IRAK10.29733992
59MTOR0.28436388
60BRD40.28399205
61IGF1R0.26625579
62LYN0.25753007
63FYN0.25001713
64PTK2B0.22389534
65TRIB30.21837689
66PRKD20.21620296
67MYLK0.20690619
68RIPK10.20554626
69FGFR40.19774677
70PRKAA10.19711494
71TNK20.19164364
72CAMK2D0.18738403
73ADRBK10.18451256
74CDK90.18194794
75CDK70.17859353
76PRKCQ0.17500085
77PIK3CA0.17422679
78ADRBK20.17000116
79PRKACA0.15541361
80STK160.15516065
81CAMK2G0.15352029
82ROCK10.14195255
83PRKCZ0.13825107
84ATR0.13693265
85PDK10.13666562
86RPS6KA30.13072281
87CCNB10.12821130
88CSF1R0.12071839
89PRKCA0.11223012
90CAMK10.11165116
91INSR0.11065037
92MAPK10.10588764
93SRC0.10528155
94EPHA20.10377921
95MAPK110.10217527
96FES0.10106597
97CAMK2A0.09879852
98HCK0.09585959
99CDK80.09130735
100PRKCB0.08732665

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006014.21525106
2Progesterone-mediated oocyte maturation_Homo sapiens_hsa049144.14177738
3Salivary secretion_Homo sapiens_hsa049703.51858054
4ABC transporters_Homo sapiens_hsa020103.29275341
5Oocyte meiosis_Homo sapiens_hsa041142.97566207
6ECM-receptor interaction_Homo sapiens_hsa045122.44795289
7Olfactory transduction_Homo sapiens_hsa047402.43375929
8Phototransduction_Homo sapiens_hsa047442.31805635
9Ovarian steroidogenesis_Homo sapiens_hsa049132.22523572
10Vibrio cholerae infection_Homo sapiens_hsa051102.21463153
11Aldosterone synthesis and secretion_Homo sapiens_hsa049252.04056575
12Protein digestion and absorption_Homo sapiens_hsa049741.88934258
13Circadian entrainment_Homo sapiens_hsa047131.85621369
14Sulfur metabolism_Homo sapiens_hsa009201.85603028
15Amoebiasis_Homo sapiens_hsa051461.80022197
16Taste transduction_Homo sapiens_hsa047421.70849394
17Fanconi anemia pathway_Homo sapiens_hsa034601.66234978
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62250764
19Nitrogen metabolism_Homo sapiens_hsa009101.59520486
20Fructose and mannose metabolism_Homo sapiens_hsa000511.55231394
21Primary immunodeficiency_Homo sapiens_hsa053401.48858023
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.45806048
23Insulin secretion_Homo sapiens_hsa049111.44590456
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38529080
25Gastric acid secretion_Homo sapiens_hsa049711.34757414
26Bile secretion_Homo sapiens_hsa049761.30814558
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.26878132
28Platelet activation_Homo sapiens_hsa046111.25616629
29Dilated cardiomyopathy_Homo sapiens_hsa054141.25351235
30Arginine and proline metabolism_Homo sapiens_hsa003301.22404513
31Thyroid hormone synthesis_Homo sapiens_hsa049181.20078417
32One carbon pool by folate_Homo sapiens_hsa006701.18498397
33Glycerolipid metabolism_Homo sapiens_hsa005611.15870103
34Linoleic acid metabolism_Homo sapiens_hsa005911.14781296
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13220946
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11097819
37Pancreatic secretion_Homo sapiens_hsa049721.10580091
38Homologous recombination_Homo sapiens_hsa034401.09074475
39Dorso-ventral axis formation_Homo sapiens_hsa043201.07837489
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.06259646
41Lysine degradation_Homo sapiens_hsa003101.05580381
42Calcium signaling pathway_Homo sapiens_hsa040201.04211641
43Glutamatergic synapse_Homo sapiens_hsa047241.04059036
44Serotonergic synapse_Homo sapiens_hsa047261.01027483
45Morphine addiction_Homo sapiens_hsa050321.00110712
46Cholinergic synapse_Homo sapiens_hsa047250.96330408
47Nicotine addiction_Homo sapiens_hsa050330.94608942
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93062744
49Renin secretion_Homo sapiens_hsa049240.92948946
50Other glycan degradation_Homo sapiens_hsa005110.87186809
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79381156
52GnRH signaling pathway_Homo sapiens_hsa049120.78171364
53Systemic lupus erythematosus_Homo sapiens_hsa053220.77736538
54cAMP signaling pathway_Homo sapiens_hsa040240.75451036
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72246888
56Arginine biosynthesis_Homo sapiens_hsa002200.71977242
57Mineral absorption_Homo sapiens_hsa049780.70985616
58Purine metabolism_Homo sapiens_hsa002300.69971807
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67663951
60Chemical carcinogenesis_Homo sapiens_hsa052040.64637664
61GABAergic synapse_Homo sapiens_hsa047270.64446731
62Starch and sucrose metabolism_Homo sapiens_hsa005000.61652087
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.61376527
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60902212
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59435353
66Long-term depression_Homo sapiens_hsa047300.58835200
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55875132
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53728566
69Ether lipid metabolism_Homo sapiens_hsa005650.52576366
70Cardiac muscle contraction_Homo sapiens_hsa042600.52359806
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51365232
72Galactose metabolism_Homo sapiens_hsa000520.51012575
73Tight junction_Homo sapiens_hsa045300.50183048
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49797078
75Retinol metabolism_Homo sapiens_hsa008300.48345889
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.47863554
77Cocaine addiction_Homo sapiens_hsa050300.46962072
78Focal adhesion_Homo sapiens_hsa045100.45804294
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45440975
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.45439841
81Inositol phosphate metabolism_Homo sapiens_hsa005620.44469920
82Gap junction_Homo sapiens_hsa045400.44416620
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43132589
84Long-term potentiation_Homo sapiens_hsa047200.41203422
85Type II diabetes mellitus_Homo sapiens_hsa049300.40976295
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.39388533
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36670412
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36661424
89Oxytocin signaling pathway_Homo sapiens_hsa049210.36265751
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.36240371
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35540466
92Amphetamine addiction_Homo sapiens_hsa050310.34795466
93Arachidonic acid metabolism_Homo sapiens_hsa005900.33548763
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32799275
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32526736
96Staphylococcus aureus infection_Homo sapiens_hsa051500.32504886
97Glutathione metabolism_Homo sapiens_hsa004800.30124938
98Notch signaling pathway_Homo sapiens_hsa043300.28338237
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.27387933
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25788009

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