ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gamma-aminobutyric acid transport (GO:0015812)	5.19282373
2	neuronal action potential propagation (GO:0019227)	4.96016687
3	negative regulation of Ras GTPase activity (GO:0034261)	4.70159718
4	detection of light stimulus involved in sensory perception (GO:0050962)	4.57966336
5	detection of light stimulus involved in visual perception (GO:0050908)	4.57966336
6	behavioral response to nicotine (GO:0035095)	4.54204759
7	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	4.32616606
8	negative regulation of mast cell activation (GO:0033004)	4.31573957
9	tachykinin receptor signaling pathway (GO:0007217)	4.28700230
10	cerebral cortex radially oriented cell migration (GO:0021799)	4.23309754
11	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.93292387
12	protein K48-linked deubiquitination (GO:0071108)	3.92645099
13	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.89070153
14	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.83522689
15	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.79570244
16	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.79198715
17	neuronal action potential (GO:0019228)	3.79097432
18	response to pheromone (GO:0019236)	3.78202025
19	startle response (GO:0001964)	3.73823005
20	synaptic transmission, glutamatergic (GO:0035249)	3.70488659
21	regulation of RIG-I signaling pathway (GO:0039535)	3.63615555
22	regulation of action potential (GO:0098900)	3.62661172
23	glutamate receptor signaling pathway (GO:0007215)	3.61626621
24	membrane depolarization during action potential (GO:0086010)	3.58534620
25	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.39457084
26	glycerophospholipid catabolic process (GO:0046475)	3.34890940
27	neuron-neuron synaptic transmission (GO:0007270)	3.30442935
28	serotonin metabolic process (GO:0042428)	3.27998197
29	protein K63-linked deubiquitination (GO:0070536)	3.17367650
30	synaptic vesicle exocytosis (GO:0016079)	3.13112458
31	adult walking behavior (GO:0007628)	3.11428032
32	regulation of protein targeting to membrane (GO:0090313)	3.07029818
33	neuron cell-cell adhesion (GO:0007158)	3.05496735
34	photoreceptor cell maintenance (GO:0045494)	3.04062713
35	central nervous system projection neuron axonogenesis (GO:0021952)	2.98824856
36	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.97366464
37	ribonucleoprotein complex disassembly (GO:0032988)	2.93370507
38	regulation of histone deacetylation (GO:0031063)	2.91170568
39	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.90465275
40	transmission of nerve impulse (GO:0019226)	2.89905858
41	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.87920463
42	regulation of voltage-gated calcium channel activity (GO:1901385)	2.85293117
43	artery development (GO:0060840)	2.84216925
44	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.83889956
45	regulation of acrosome reaction (GO:0060046)	2.82980910
46	central nervous system neuron axonogenesis (GO:0021955)	2.82540890
47	primary amino compound metabolic process (GO:1901160)	2.82469853
48	nerve growth factor signaling pathway (GO:0038180)	2.80941264
49	spinal cord motor neuron differentiation (GO:0021522)	2.80011108
50	pyrimidine nucleobase catabolic process (GO:0006208)	2.76907226
51	neuron fate determination (GO:0048664)	2.75668427
52	negative regulation of systemic arterial blood pressure (GO:0003085)	2.74682521
53	positive regulation of action potential (GO:0045760)	2.74390896
54	C4-dicarboxylate transport (GO:0015740)	2.73940059
55	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.72409123
56	inner ear receptor cell development (GO:0060119)	2.71858595
57	retina vasculature morphogenesis in camera-type eye (GO:0061299)	2.71434527
58	neuron recognition (GO:0008038)	2.69740095
59	mitotic sister chromatid cohesion (GO:0007064)	2.68269263
60	interkinetic nuclear migration (GO:0022027)	2.66275845
61	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.65558443
62	organelle disassembly (GO:1903008)	2.63823132
63	synaptic transmission, cholinergic (GO:0007271)	2.63627723
64	axonal fasciculation (GO:0007413)	2.63073630
65	action potential (GO:0001508)	2.62633115
66	retina layer formation (GO:0010842)	2.62611609
67	neuromuscular synaptic transmission (GO:0007274)	2.62555351
68	response to nitrosative stress (GO:0051409)	2.62377302
69	protein polyglutamylation (GO:0018095)	2.62268657
70	behavioral response to ethanol (GO:0048149)	2.62185939
71	regulation of ruffle assembly (GO:1900027)	2.61673180
72	synapse assembly (GO:0007416)	2.61634368
73	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.61516666
74	cellular ketone body metabolic process (GO:0046950)	2.60887386
75	regulation of feeding behavior (GO:0060259)	2.60353073
76	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	2.59979680
77	DNA damage induced protein phosphorylation (GO:0006975)	2.58730811
78	regulation of synaptic transmission, GABAergic (GO:0032228)	2.58347114
79	cilium or flagellum-dependent cell motility (GO:0001539)	2.58156809
80	indolalkylamine metabolic process (GO:0006586)	2.57189320
81	indole-containing compound metabolic process (GO:0042430)	2.55692778
82	neural tube formation (GO:0001841)	2.55331390
83	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	2.55288608
84	response to caffeine (GO:0031000)	2.53502453
85	nonmotile primary cilium assembly (GO:0035058)	2.53096627
86	homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	2.52198598
87	auditory receptor cell stereocilium organization (GO:0060088)	2.51816530
88	regulation of penile erection (GO:0060405)	2.48411335
89	microtubule anchoring (GO:0034453)	2.47205702
90	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	2.46444415
91	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.46339074
92	negative regulation of catecholamine secretion (GO:0033604)	2.46116709
93	membrane depolarization (GO:0051899)	2.45838519
94	regulation of protein deacetylation (GO:0090311)	2.45201763
95	single strand break repair (GO:0000012)	2.44187547
96	regulation of cardiac muscle cell contraction (GO:0086004)	2.43521011
97	innervation (GO:0060384)	2.43054423
98	cAMP-mediated signaling (GO:0019933)	2.42713812
99	positive regulation of cAMP-mediated signaling (GO:0043950)	2.42256711
100	presynaptic membrane assembly (GO:0097105)	2.42119029

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.64274223
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.87163122
3	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.09156518
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.06103661
5	VDR_22108803_ChIP-Seq_LS180_Human	3.03619155
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.79944351
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.78519413
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.73720689
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.50186098
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.43174785
11	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.41377913
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.35915711
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.30539931
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.18609710
15	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.11944743
16	P300_19829295_ChIP-Seq_ESCs_Human	2.08831541
17	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.01541330
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.99169383
19	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.97382979
20	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.97368982
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.96390851
22	STAT3_23295773_ChIP-Seq_U87_Human	1.92044249
23	AR_21572438_ChIP-Seq_LNCaP_Human	1.89958898
24	DROSHA_22980978_ChIP-Seq_HELA_Human	1.86018134
25	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.83633670
26	EWS_26573619_Chip-Seq_HEK293_Human	1.80614859
27	TCF4_23295773_ChIP-Seq_U87_Human	1.73842719
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.72655640
29	FUS_26573619_Chip-Seq_HEK293_Human	1.72197164
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.70364942
31	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.66924744
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.66513597
33	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.66513597
34	REST_21632747_ChIP-Seq_MESCs_Mouse	1.65488030
35	AR_25329375_ChIP-Seq_VCAP_Human	1.64346558
36	RUNX2_22187159_ChIP-Seq_PCA_Human	1.61937010
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61656797
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.59099326
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.58715853
40	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.57389481
41	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.57382408
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.48965480
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47444266
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.47444266
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.46088935
46	KDM2B_26808549_Chip-Seq_REH_Human	1.43834640
47	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.42098532
48	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.41870433
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40516493
50	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.40069427
51	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.39869954
52	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.39312574
53	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.37083596
54	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36372699
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35979456
56	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.35918736
57	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.33952121
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.31909035
59	TP53_16413492_ChIP-PET_HCT116_Human	1.31879896
60	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.28244883
61	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.26384099
62	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.21046856
63	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.20713924
64	AHR_22903824_ChIP-Seq_MCF-7_Human	1.20648829
65	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.20632967
66	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.19971400
67	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.19608779
68	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.19088001
69	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.17836152
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17709617
71	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.16850285
72	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.16187773
73	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.15552761
74	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15240396
75	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.13760667
76	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.10426993
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09837881
78	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.09717244
79	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.08546356
80	TP53_18474530_ChIP-ChIP_U2OS_Human	1.08401375
81	NCOR_22424771_ChIP-Seq_293T_Human	1.06710610
82	AR_19668381_ChIP-Seq_PC3_Human	1.06381867
83	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.06063177
84	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.05680347
85	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.05680347
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05094330
87	SOX9_26525672_Chip-Seq_HEART_Mouse	1.04114298
88	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.03459078
89	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.03390288
90	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.02822851
91	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02525342
92	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02433176
93	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.01127031
94	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.00455430
95	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.99804792
96	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.99105634
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.99094880
98	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.97973306
99	JUN_21703547_ChIP-Seq_K562_Human	0.96394931
100	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.95097268

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	5.16348316
2	MP0002822_catalepsy	4.66943567
3	MP0002102_abnormal_ear_morphology	4.54571342
4	MP0002735_abnormal_chemical_nociception	2.93849550
5	MP0006292_abnormal_olfactory_placode	2.91174580
6	MP0005551_abnormal_eye_electrophysiolog	2.70704475
7	MP0003880_abnormal_central_pattern	2.55710621
8	MP0009046_muscle_twitch	2.51542996
9	MP0001968_abnormal_touch/_nociception	2.51170832
10	MP0001486_abnormal_startle_reflex	2.36237138
11	MP0004270_analgesia	2.23469881
12	MP0009745_abnormal_behavioral_response	2.19718531
13	MP0004859_abnormal_synaptic_plasticity	2.18689218
14	MP0001986_abnormal_taste_sensitivity	2.13993971
15	MP0000778_abnormal_nervous_system	2.13387535
16	MP0002272_abnormal_nervous_system	2.08024585
17	MP0003635_abnormal_synaptic_transmissio	2.04278780
18	MP0002736_abnormal_nociception_after	2.03688055
19	MP0002734_abnormal_mechanical_nocicepti	2.03556251
20	MP0004885_abnormal_endolymph	1.95429497
21	MP0008877_abnormal_DNA_methylation	1.90113881
22	MP0002064_seizures	1.88859064
23	MP0003183_abnormal_peptide_metabolism	1.73145692
24	MP0005386_behavior/neurological_phenoty	1.70585792
25	MP0004924_abnormal_behavior	1.70585792
26	MP0000427_abnormal_hair_cycle	1.70413357
27	MP0002653_abnormal_ependyma_morphology	1.69897413
28	MP0002234_abnormal_pharynx_morphology	1.67247645
29	MP0001970_abnormal_pain_threshold	1.66119867
30	MP0002572_abnormal_emotion/affect_behav	1.63233069
31	MP0005248_abnormal_Harderian_gland	1.61328296
32	MP0002063_abnormal_learning/memory/cond	1.55142251
33	MP0003879_abnormal_hair_cell	1.54308642
34	MP0002067_abnormal_sensory_capabilities	1.50664606
35	MP0002733_abnormal_thermal_nociception	1.45750722
36	MP0001529_abnormal_vocalization	1.43852721
37	MP0001984_abnormal_olfaction	1.43096952
38	MP0000631_abnormal_neuroendocrine_gland	1.42517708
39	MP0005423_abnormal_somatic_nervous	1.40081608
40	MP0004043_abnormal_pH_regulation	1.35739929
41	MP0002184_abnormal_innervation	1.30990237
42	MP0005253_abnormal_eye_physiology	1.29607656
43	MP0001963_abnormal_hearing_physiology	1.26724752
44	MP0000955_abnormal_spinal_cord	1.26132217
45	MP0009780_abnormal_chondrocyte_physiolo	1.24609402
46	MP0002752_abnormal_somatic_nervous	1.24525677
47	MP0005645_abnormal_hypothalamus_physiol	1.24249103
48	MP0006072_abnormal_retinal_apoptosis	1.24221281
49	MP0002882_abnormal_neuron_morphology	1.23991379
50	MP0003890_abnormal_embryonic-extraembry	1.23108986
51	MP0003718_maternal_effect	1.19204851
52	MP0005499_abnormal_olfactory_system	1.18067877
53	MP0005394_taste/olfaction_phenotype	1.18067877
54	MP0004742_abnormal_vestibular_system	1.15992941
55	MP0008789_abnormal_olfactory_epithelium	1.15185957
56	MP0001485_abnormal_pinna_reflex	1.14424485
57	MP0002938_white_spotting	1.13617501
58	MP0000026_abnormal_inner_ear	1.12100603
59	MP0002090_abnormal_vision	1.11663848
60	MP0006276_abnormal_autonomic_nervous	1.11144711
61	MP0005195_abnormal_posterior_eye	1.08059557
62	MP0002229_neurodegeneration	1.07807632
63	MP0001501_abnormal_sleep_pattern	1.05314588
64	MP0005174_abnormal_tail_pigmentation	1.02405478
65	MP0002557_abnormal_social/conspecific_i	1.00700587
66	MP0001188_hyperpigmentation	0.99037799
67	MP0005187_abnormal_penis_morphology	0.97137088
68	MP0003195_calcinosis	0.96980034
69	MP0003633_abnormal_nervous_system	0.94638513
70	MP0003283_abnormal_digestive_organ	0.89997756
71	MP0003122_maternal_imprinting	0.88312720
72	MP0010386_abnormal_urinary_bladder	0.87262766
73	MP0001440_abnormal_grooming_behavior	0.86829897
74	MP0008872_abnormal_physiological_respon	0.86647877
75	MP0003878_abnormal_ear_physiology	0.85042765
76	MP0005377_hearing/vestibular/ear_phenot	0.85042765
77	MP0002152_abnormal_brain_morphology	0.84348329
78	MP0001293_anophthalmia	0.83837418
79	MP0002638_abnormal_pupillary_reflex	0.83389561
80	MP0000383_abnormal_hair_follicle	0.83167338
81	MP0002066_abnormal_motor_capabilities/c	0.83026649
82	MP0003045_fibrosis	0.82967236
83	MP0005391_vision/eye_phenotype	0.81999310
84	MP0001879_abnormal_lymphatic_vessel	0.80502205
85	MP0002751_abnormal_autonomic_nervous	0.79453170
86	MP0000462_abnormal_digestive_system	0.76239889
87	MP0004215_abnormal_myocardial_fiber	0.75422567
88	MP0008058_abnormal_DNA_repair	0.72572653
89	MP0002233_abnormal_nose_morphology	0.71909451
90	MP0002160_abnormal_reproductive_system	0.71484749
91	MP0005410_abnormal_fertilization	0.69283102
92	MP0003631_nervous_system_phenotype	0.69069047
93	MP0003698_abnormal_male_reproductive	0.68651546
94	MP0004811_abnormal_neuron_physiology	0.68057600
95	MP0008569_lethality_at_weaning	0.67974812
96	MP0004085_abnormal_heartbeat	0.67739296
97	MP0004145_abnormal_muscle_electrophysio	0.66460835
98	MP0002249_abnormal_larynx_morphology	0.66231060
99	MP0003119_abnormal_digestive_system	0.65334187
100	MP0005646_abnormal_pituitary_gland	0.65266327

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	4.60238356
2	Focal seizures (HP:0007359)	4.08623300
3	Hyperventilation (HP:0002883)	4.02241802
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.01486428
5	Absent/shortened dynein arms (HP:0200106)	4.01486428
6	Atonic seizures (HP:0010819)	3.81842794
7	Chronic hepatic failure (HP:0100626)	3.76566974
8	Gaze-evoked nystagmus (HP:0000640)	3.56900442
9	Febrile seizures (HP:0002373)	3.52879572
10	Genetic anticipation (HP:0003743)	3.25939097
11	Progressive cerebellar ataxia (HP:0002073)	3.25571321
12	Homocystinuria (HP:0002156)	3.22890120
13	Abnormality of homocysteine metabolism (HP:0010919)	3.22890120
14	Poor eye contact (HP:0000817)	3.17061303
15	Fair hair (HP:0002286)	3.16756026
16	Methylmalonic acidemia (HP:0002912)	3.07682621
17	Dialeptic seizures (HP:0011146)	3.07590839
18	Epileptic encephalopathy (HP:0200134)	2.97738817
19	Medial flaring of the eyebrow (HP:0010747)	2.91187007
20	Gait imbalance (HP:0002141)	2.86430737
21	Nephrogenic diabetes insipidus (HP:0009806)	2.82537887
22	Abnormality of the renal cortex (HP:0011035)	2.77452473
23	Protruding tongue (HP:0010808)	2.74945616
24	Drooling (HP:0002307)	2.74415425
25	Pancreatic cysts (HP:0001737)	2.72474885
26	Abnormality of methionine metabolism (HP:0010901)	2.72296986
27	Abnormal respiratory motile cilium morphology (HP:0005938)	2.70434868
28	Abnormal respiratory epithelium morphology (HP:0012253)	2.70434868
29	Generalized hypopigmentation of hair (HP:0011358)	2.69092502
30	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.68435604
31	Birth length less than 3rd percentile (HP:0003561)	2.64548710
32	Abnormal ciliary motility (HP:0012262)	2.59209128
33	Dyskinesia (HP:0100660)	2.58892351
34	Congenital primary aphakia (HP:0007707)	2.57218864
35	Methylmalonic aciduria (HP:0012120)	2.56717150
36	Epileptiform EEG discharges (HP:0011182)	2.52324929
37	Excessive salivation (HP:0003781)	2.52059213
38	Genital tract atresia (HP:0001827)	2.48734801
39	EEG with generalized epileptiform discharges (HP:0011198)	2.45708371
40	Hypsarrhythmia (HP:0002521)	2.45559572
41	Impaired social interactions (HP:0000735)	2.42726121
42	Abnormal social behavior (HP:0012433)	2.42726121
43	Absence seizures (HP:0002121)	2.42689033
44	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.42664915
45	Nephronophthisis (HP:0000090)	2.42661463
46	Vaginal atresia (HP:0000148)	2.42161815
47	Broad-based gait (HP:0002136)	2.41871705
48	Molar tooth sign on MRI (HP:0002419)	2.41799036
49	Abnormality of midbrain morphology (HP:0002418)	2.41799036
50	Status epilepticus (HP:0002133)	2.40056649
51	Abnormality of the metopic suture (HP:0005556)	2.39468299
52	Amyotrophic lateral sclerosis (HP:0007354)	2.38810476
53	True hermaphroditism (HP:0010459)	2.37505293
54	Widely spaced teeth (HP:0000687)	2.36952731
55	Hemiplegia (HP:0002301)	2.36056313
56	Pancreatic fibrosis (HP:0100732)	2.35931886
57	Attenuation of retinal blood vessels (HP:0007843)	2.33415661
58	Abnormality of the renal medulla (HP:0100957)	2.29061203
59	Volvulus (HP:0002580)	2.28455927
60	Poor coordination (HP:0002370)	2.23657224
61	Truncal obesity (HP:0001956)	2.19438691
62	3-Methylglutaconic aciduria (HP:0003535)	2.15190632
63	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.15149136
64	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.14575189
65	Gastroesophageal reflux (HP:0002020)	2.10805592
66	Partial agenesis of the corpus callosum (HP:0001338)	2.10146484
67	Renal cortical cysts (HP:0000803)	2.07186706
68	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.06837102
69	Absent eyebrow (HP:0002223)	2.05536106
70	Hemiparesis (HP:0001269)	2.03760174
71	Intestinal atresia (HP:0011100)	2.01489607
72	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.01352453
73	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.01352453
74	Broad alveolar ridges (HP:0000187)	1.97642670
75	Abnormality of the astrocytes (HP:0100707)	1.96351853
76	Astrocytoma (HP:0009592)	1.96351853
77	Clumsiness (HP:0002312)	1.94682323
78	Wide intermamillary distance (HP:0006610)	1.94491257
79	Aplasia/Hypoplasia of the lens (HP:0008063)	1.94016343
80	Biliary tract neoplasm (HP:0100574)	1.93151355
81	Sclerocornea (HP:0000647)	1.92920078
82	Abnormal auditory evoked potentials (HP:0006958)	1.91781373
83	Gonadotropin excess (HP:0000837)	1.91619511
84	Inability to walk (HP:0002540)	1.90194227
85	Astigmatism (HP:0000483)	1.89871170
86	Abnormality of vitamin B metabolism (HP:0004340)	1.89795485
87	Small hand (HP:0200055)	1.88675926
88	Generalized tonic-clonic seizures (HP:0002069)	1.85263655
89	Abnormal respiratory motile cilium physiology (HP:0012261)	1.84041464
90	Bony spicule pigmentary retinopathy (HP:0007737)	1.83782825
91	Hip dysplasia (HP:0001385)	1.83066098
92	Absent speech (HP:0001344)	1.81934618
93	Carpal bone hypoplasia (HP:0001498)	1.80927512
94	Prolonged QT interval (HP:0001657)	1.79563920
95	Decreased central vision (HP:0007663)	1.79416390
96	Cupped ear (HP:0000378)	1.78758141
97	Prominent metopic ridge (HP:0005487)	1.78517342
98	Abnormality of the parathyroid morphology (HP:0011766)	1.78412577
99	Abnormality of the corticospinal tract (HP:0002492)	1.77446863
100	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.76221715

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	5.92842645
2	MAP3K4	3.98344936
3	FRK	3.66162084
4	MAP2K7	3.42679649
5	MAP4K2	3.41895852
6	MARK1	3.22572515
7	MAP3K6	2.86032743
8	DYRK3	2.45401129
9	CCNB1	2.12563600
10	CASK	2.03003350
11	AKT3	1.86083775
12	EPHA4	1.80359029
13	NTRK3	1.76831576
14	INSRR	1.76780602
15	CAMKK2	1.53627000
16	MAPK13	1.53324029
17	MAP2K4	1.51260050
18	PNCK	1.51026034
19	ZAK	1.48760764
20	PBK	1.42016130
21	TNIK	1.40642159
22	SIK2	1.39408310
23	ADRBK2	1.37911773
24	GRK1	1.37233207
25	SGK2	1.35374604
26	CAMK1G	1.34604633
27	LATS1	1.33692383
28	BMPR1B	1.33094652
29	TAOK3	1.21455936
30	SGK494	1.17762267
31	SGK223	1.17762267
32	PTK2B	1.08326578
33	WNK3	1.06274470
34	NTRK2	1.06255913
35	ACVR1B	0.99109551
36	CSNK1A1L	0.94349021
37	TEC	0.86013927
38	BCR	0.85962179
39	ERBB3	0.85680099
40	CSNK1G2	0.85419696
41	CAMK4	0.82410746
42	NUAK1	0.79316639
43	CAMKK1	0.78372457
44	STK39	0.76787273
45	SRPK1	0.74767603
46	NEK9	0.74722559
47	WNK1	0.72010317
48	MINK1	0.71930343
49	PIK3CA	0.71526391
50	ITK	0.68455252
51	CAMK2A	0.67571149
52	WNK4	0.65216328
53	PRKCE	0.63678821
54	CAMK1D	0.63450866
55	BRSK2	0.62790213
56	PAK3	0.62131427
57	BMPR2	0.59141128
58	CLK1	0.58318856
59	CDK5	0.58289352
60	CSNK1G3	0.58265337
61	MAP3K13	0.57785592
62	SCYL2	0.57260992
63	CAMK1	0.57249792
64	CSNK1G1	0.56852102
65	TTK	0.56821333
66	MAP2K6	0.56531828
67	MAP3K5	0.55330216
68	DYRK1A	0.55152000
69	MKNK2	0.53801527
70	SGK1	0.52869587
71	DYRK2	0.52190093
72	PRKG1	0.49873827
73	PRKCG	0.48004308
74	OXSR1	0.47882098
75	TYRO3	0.47475062
76	CAMK2B	0.45770922
77	STK38	0.43182288
78	PHKG2	0.41788184
79	PHKG1	0.41788184
80	MET	0.41143623
81	PKN1	0.40722897
82	PINK1	0.39866529
83	CDK3	0.39845330
84	FER	0.39714997
85	PASK	0.38789067
86	CSNK1A1	0.38629062
87	ERBB2	0.36950804
88	PRKCB	0.36272613
89	PLK1	0.35677016
90	RPS6KA3	0.33294042
91	STK3	0.31517904
92	GSK3B	0.31416809
93	ATM	0.30974143
94	SGK3	0.30890625
95	CSNK1D	0.29508713
96	PRKACB	0.28574523
97	EPHB2	0.26360935
98	NME1	0.25655829
99	OBSCN	0.25140783
100	ADRBK1	0.24817433

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.08110656
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.98843382
3	Phototransduction_Homo sapiens_hsa04744	2.94225108
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.68696879
5	Morphine addiction_Homo sapiens_hsa05032	2.63695864
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.61999433
7	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.52847650
8	Circadian entrainment_Homo sapiens_hsa04713	2.31666054
9	Glutamatergic synapse_Homo sapiens_hsa04724	2.28698460
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.16398578
11	GABAergic synapse_Homo sapiens_hsa04727	2.06947474
12	Cocaine addiction_Homo sapiens_hsa05030	2.00628272
13	Taste transduction_Homo sapiens_hsa04742	1.99214156
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.91815885
15	Long-term depression_Homo sapiens_hsa04730	1.90002224
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.83366880
17	Serotonergic synapse_Homo sapiens_hsa04726	1.83203856
18	Dopaminergic synapse_Homo sapiens_hsa04728	1.71015515
19	Insulin secretion_Homo sapiens_hsa04911	1.70635229
20	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.70170004
21	Olfactory transduction_Homo sapiens_hsa04740	1.66001036
22	Amphetamine addiction_Homo sapiens_hsa05031	1.58778311
23	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.56270184
24	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.50999831
25	Salivary secretion_Homo sapiens_hsa04970	1.45329255
26	Type II diabetes mellitus_Homo sapiens_hsa04930	1.41515480
27	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.39706928
28	Cholinergic synapse_Homo sapiens_hsa04725	1.33009679
29	Regulation of autophagy_Homo sapiens_hsa04140	1.31197849
30	ABC transporters_Homo sapiens_hsa02010	1.17295892
31	Calcium signaling pathway_Homo sapiens_hsa04020	1.14770115
32	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.12451480
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.11963465
34	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.07621398
35	Butanoate metabolism_Homo sapiens_hsa00650	1.03812877
36	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.03470435
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.01758168
38	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.00830405
39	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.98115184
40	Ras signaling pathway_Homo sapiens_hsa04014	0.97340386
41	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97083122
42	cAMP signaling pathway_Homo sapiens_hsa04024	0.97021069
43	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.91169279
44	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.90531721
45	Histidine metabolism_Homo sapiens_hsa00340	0.90059275
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.88496492
47	Estrogen signaling pathway_Homo sapiens_hsa04915	0.87379671
48	Long-term potentiation_Homo sapiens_hsa04720	0.84602607
49	Gastric acid secretion_Homo sapiens_hsa04971	0.84517214
50	Choline metabolism in cancer_Homo sapiens_hsa05231	0.81191047
51	Sulfur metabolism_Homo sapiens_hsa00920	0.79325431
52	Renin secretion_Homo sapiens_hsa04924	0.79251826
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77368002
54	MAPK signaling pathway_Homo sapiens_hsa04010	0.77057752
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.76650015
56	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.73017337
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.71057843
58	Basal transcription factors_Homo sapiens_hsa03022	0.70535622
59	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.69755495
60	Oocyte meiosis_Homo sapiens_hsa04114	0.67306150
61	Gap junction_Homo sapiens_hsa04540	0.67246357
62	Circadian rhythm_Homo sapiens_hsa04710	0.67092618
63	Axon guidance_Homo sapiens_hsa04360	0.65576907
64	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.65528199
65	ErbB signaling pathway_Homo sapiens_hsa04012	0.65064247
66	Peroxisome_Homo sapiens_hsa04146	0.64882683
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64708120
68	Alcoholism_Homo sapiens_hsa05034	0.63125470
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60924957
70	Pancreatic secretion_Homo sapiens_hsa04972	0.60529116
71	GnRH signaling pathway_Homo sapiens_hsa04912	0.60070433
72	Homologous recombination_Homo sapiens_hsa03440	0.59826726
73	Basal cell carcinoma_Homo sapiens_hsa05217	0.57756222
74	Wnt signaling pathway_Homo sapiens_hsa04310	0.57235198
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.54688931
76	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.54569753
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.53888612
78	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.53210616
79	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.51091670
80	Protein export_Homo sapiens_hsa03060	0.49777475
81	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.48386446
82	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.48208995
83	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.48115146
84	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.47253815
85	Melanogenesis_Homo sapiens_hsa04916	0.46654793
86	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46634856
87	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.46564507
88	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46447054
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46101570
90	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.44953206
91	Rap1 signaling pathway_Homo sapiens_hsa04015	0.44846132
92	Cardiac muscle contraction_Homo sapiens_hsa04260	0.43474968
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.40635295
94	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.40539277
95	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.40209411
96	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.39285385
97	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.39167176
98	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.38472194
99	Bile secretion_Homo sapiens_hsa04976	0.36958607
100	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.36604032

USP17L7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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