ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	leukotriene metabolic process (GO:0006691)	9.33178101
2	digestion (GO:0007586)	9.25450001
3	intestinal absorption (GO:0050892)	8.12530978
4	transcytosis (GO:0045056)	8.00481414
5	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	7.79210926
6	fatty acid derivative biosynthetic process (GO:1901570)	7.48647690
7	icosanoid biosynthetic process (GO:0046456)	7.48647690
8	bundle of His cell to Purkinje myocyte communication (GO:0086069)	6.85510239
9	unsaturated fatty acid biosynthetic process (GO:0006636)	6.16641312
10	peptidyl-proline hydroxylation (GO:0019511)	5.94872312
11	cobalamin metabolic process (GO:0009235)	5.73982907
12	protein retention in ER lumen (GO:0006621)	5.72681098
13	peptide catabolic process (GO:0043171)	5.36324699
14	glutathione metabolic process (GO:0006749)	5.22524576
15	cholesterol catabolic process (GO:0006707)	5.20345941
16	sterol catabolic process (GO:0016127)	5.20345941
17	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	4.83624703
18	phosphatidylinositol acyl-chain remodeling (GO:0036149)	4.68784107
19	mitochondrion distribution (GO:0048311)	4.59018310
20	glycolipid catabolic process (GO:0019377)	4.57369432
21	membrane lipid catabolic process (GO:0046466)	4.28737910
22	regulation of phospholipase A2 activity (GO:0032429)	4.28649522
23	cilium or flagellum-dependent cell motility (GO:0001539)	4.23139352
24	protein hydroxylation (GO:0018126)	4.20699834
25	cysteine metabolic process (GO:0006534)	4.19688650
26	fatty acid derivative metabolic process (GO:1901568)	4.08071536
27	icosanoid metabolic process (GO:0006690)	4.08071536
28	detection of molecule of bacterial origin (GO:0032490)	4.05786993
29	regulation of G0 to G1 transition (GO:0070316)	4.04947224
30	digestive system process (GO:0022600)	3.94103200
31	ceramide catabolic process (GO:0046514)	3.91580335
32	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.86549964
33	mitochondrial calcium ion transport (GO:0006851)	3.86505917
34	neuronal action potential (GO:0019228)	3.84990312
35	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.84775216
36	sterol transport (GO:0015918)	3.65289267
37	cholesterol transport (GO:0030301)	3.65289267
38	gonadal mesoderm development (GO:0007506)	3.59807149
39	membrane depolarization during action potential (GO:0086010)	3.51965383
40	regulation of RIG-I signaling pathway (GO:0039535)	3.49323657
41	neutrophil mediated immunity (GO:0002446)	3.44576165
42	protein K48-linked deubiquitination (GO:0071108)	3.43919759
43	unsaturated fatty acid metabolic process (GO:0033559)	3.41946674
44	protein prenylation (GO:0018342)	3.27959970
45	prenylation (GO:0097354)	3.27959970
46	maintenance of gastrointestinal epithelium (GO:0030277)	3.24542389
47	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.23255878
48	positive regulation of endothelial cell differentiation (GO:0045603)	3.15922543
49	imidazole-containing compound metabolic process (GO:0052803)	3.11451125
50	regulation of endothelial cell differentiation (GO:0045601)	3.09939841
51	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.02437416
52	phospholipid catabolic process (GO:0009395)	3.02194401
53	regulation of hippo signaling (GO:0035330)	3.01962421
54	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.01033904
55	cerebellar Purkinje cell differentiation (GO:0021702)	2.93082392
56	icosanoid secretion (GO:0032309)	2.91894113
57	arachidonic acid secretion (GO:0050482)	2.91894113
58	negative regulation of epidermal cell differentiation (GO:0045605)	2.88517561
59	negative regulation of protein localization to cell surface (GO:2000009)	2.87941087
60	sulfation (GO:0051923)	2.86234635
61	fatty acid biosynthetic process (GO:0006633)	2.84376299
62	peristalsis (GO:0030432)	2.72582186
63	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.71026527
64	one-carbon compound transport (GO:0019755)	2.69968704
65	peptide metabolic process (GO:0006518)	2.68161670
66	myeloid leukocyte mediated immunity (GO:0002444)	2.64792770
67	cell communication involved in cardiac conduction (GO:0086065)	2.62575552
68	androgen biosynthetic process (GO:0006702)	2.60905698
69	phosphatidic acid biosynthetic process (GO:0006654)	2.58719831
70	phosphatidic acid metabolic process (GO:0046473)	2.58719831
71	microglial cell activation (GO:0001774)	2.47081275
72	glutamate metabolic process (GO:0006536)	2.46620669
73	establishment of skin barrier (GO:0061436)	2.45692614
74	negative regulation of Ras GTPase activity (GO:0034261)	2.45423333
75	musculoskeletal movement (GO:0050881)	2.44589885
76	multicellular organismal movement (GO:0050879)	2.44589885
77	phosphatidylserine metabolic process (GO:0006658)	2.43387726
78	protein K63-linked deubiquitination (GO:0070536)	2.41263092
79	interkinetic nuclear migration (GO:0022027)	2.41220927
80	motile cilium assembly (GO:0044458)	2.38876187
81	glycine transport (GO:0015816)	2.31805431
82	import into cell (GO:0098657)	2.31148498
83	serotonin metabolic process (GO:0042428)	2.29435163
84	icosanoid transport (GO:0071715)	2.29172276
85	fatty acid derivative transport (GO:1901571)	2.29172276
86	regulation of ruffle assembly (GO:1900027)	2.28826229
87	bone remodeling (GO:0046849)	2.24804591
88	phosphatidylglycerol metabolic process (GO:0046471)	2.24289887
89	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.23163530
90	nerve growth factor signaling pathway (GO:0038180)	2.21525594
91	glutathione biosynthetic process (GO:0006750)	2.19413322
92	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.18183908
93	cAMP biosynthetic process (GO:0006171)	2.17201942
94	epithelial structure maintenance (GO:0010669)	2.16983617
95	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.16343528
96	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.16211607
97	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.16211607
98	cellular modified amino acid catabolic process (GO:0042219)	2.15703798
99	intestinal cholesterol absorption (GO:0030299)	18.3880028
100	leukotriene biosynthetic process (GO:0019370)	13.5273695

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.73623270
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.76587085
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.33772522
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.19390073
5	VDR_22108803_ChIP-Seq_LS180_Human	2.96596464
6	DROSHA_22980978_ChIP-Seq_HELA_Human	2.73164108
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.53363273
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.18633152
9	GATA1_22025678_ChIP-Seq_K562_Human	2.02209088
10	AR_21572438_ChIP-Seq_LNCaP_Human	1.86757811
11	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.80005140
12	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.77436497
13	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.71952892
14	TP53_16413492_ChIP-PET_HCT116_Human	1.69576213
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.67258949
16	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.67112279
17	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.64618524
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.61693070
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.52442507
20	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.50269680
21	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49673880
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.47684852
23	STAT3_23295773_ChIP-Seq_U87_Human	1.47377454
24	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.46358182
25	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.45756006
26	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.44756409
27	P300_19829295_ChIP-Seq_ESCs_Human	1.43346978
28	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.41442051
29	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.41134231
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.39249503
31	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.36617168
32	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.36511304
33	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.34865640
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.32967722
35	NFYA_21822215_ChIP-Seq_K562_Human	1.32495141
36	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.30487718
37	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.30448943
38	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.29542113
39	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.29086839
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.28665214
41	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.27566217
42	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.26155278
43	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.23880393
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.23865988
45	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.23842123
46	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.22259965
47	TCF4_23295773_ChIP-Seq_U87_Human	1.20282624
48	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18437418
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.18183557
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18183557
51	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.17805213
52	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.16835543
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14066528
54	TBL1_22424771_ChIP-Seq_293T_Human	1.13095628
55	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.12791375
56	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10480893
57	CDX2_22108803_ChIP-Seq_LS180_Human	1.10469952
58	CJUN_26792858_Chip-Seq_BT549_Human	1.10117389
59	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.09928446
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09832297
61	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.09810567
62	ER_23166858_ChIP-Seq_MCF-7_Human	1.09305690
63	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.08927320
64	NFYB_21822215_ChIP-Seq_K562_Human	1.07784908
65	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.07517784
66	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.05996787
67	REST_21632747_ChIP-Seq_MESCs_Mouse	1.04660013
68	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.02457672
69	RXR_22108803_ChIP-Seq_LS180_Human	1.02132849
70	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.01894267
71	CBP_21632823_ChIP-Seq_H3396_Human	1.01608975
72	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.00396312
73	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.98609853
74	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.98339740
75	AHR_22903824_ChIP-Seq_MCF-7_Human	0.96421143
76	KLF5_25053715_ChIP-Seq_YYC3_Human	0.96144342
77	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.95918866
78	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.95805937
79	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.95793813
80	PHF8_20622853_ChIP-Seq_HELA_Human	0.95639415
81	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.95067859
82	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.94692149
83	TCF4_22108803_ChIP-Seq_LS180_Human	0.94614919
84	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.94334877
85	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.94029293
86	IRF1_19129219_ChIP-ChIP_H3396_Human	0.92748374
87	OCT4_20526341_ChIP-Seq_ESCs_Human	0.91979657
88	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.91899815
89	AR_19668381_ChIP-Seq_PC3_Human	0.91758854
90	LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.91711327
91	KDM2B_26808549_Chip-Seq_REH_Human	0.91604084
92	ETV1_20927104_ChIP-Seq_GIST48_Human	0.91216574
93	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.91168292
94	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.90997325
95	AR_25329375_ChIP-Seq_VCAP_Human	0.90650555
96	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.90168744
97	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.89274199
98	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.88878181
99	TP53_18474530_ChIP-ChIP_U2OS_Human	0.88443203
100	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.87808363

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001666_abnormal_nutrient_absorption	8.49932468
2	MP0003868_abnormal_feces_composition	5.80954873
3	MP0003183_abnormal_peptide_metabolism	5.35455877
4	MP0003959_abnormal_lean_body	4.34012502
5	MP0005365_abnormal_bile_salt	3.91016795
6	MP0000569_abnormal_digit_pigmentation	3.76101272
7	MP0005220_abnormal_exocrine_pancreas	3.39584729
8	MP0002736_abnormal_nociception_after	3.28158795
9	MP0003878_abnormal_ear_physiology	2.80693094
10	MP0005377_hearing/vestibular/ear_phenot	2.80693094
11	MP0002822_catalepsy	2.75729929
12	MP0000465_gastrointestinal_hemorrhage	2.67638604
13	MP0003300_gastrointestinal_ulcer	2.55148370
14	MP0000613_abnormal_salivary_gland	2.36269927
15	MP0001968_abnormal_touch/_nociception	2.33232224
16	MP0003195_calcinosis	2.27314368
17	MP0002163_abnormal_gland_morphology	2.26005709
18	MP0002138_abnormal_hepatobiliary_system	2.24573568
19	MP0003879_abnormal_hair_cell	2.08245815
20	MP0002089_abnormal_postnatal_growth/wei	2.07231070
21	MP0003045_fibrosis	2.01102669
22	MP0005448_abnormal_energy_balance	1.80160208
23	MP0005083_abnormal_biliary_tract	1.78442942
24	MP0001485_abnormal_pinna_reflex	1.70339952
25	MP0003950_abnormal_plasma_membrane	1.44823178
26	MP0001501_abnormal_sleep_pattern	1.42994697
27	MP0005379_endocrine/exocrine_gland_phen	1.30594640
28	MP0002733_abnormal_thermal_nociception	1.28776817
29	MP0002332_abnormal_exercise_endurance	1.28618750
30	MP0003136_yellow_coat_color	1.26255370
31	MP0000371_diluted_coat_color	1.19524068
32	MP0004043_abnormal_pH_regulation	1.17114266
33	MP0008995_early_reproductive_senescence	1.15911333
34	MP0001879_abnormal_lymphatic_vessel	1.15741724
35	MP0002735_abnormal_chemical_nociception	1.15032895
36	MP0005551_abnormal_eye_electrophysiolog	1.14447992
37	MP0004264_abnormal_extraembryonic_tissu	1.11803032
38	MP0003866_abnormal_defecation	1.10608425
39	MP0010678_abnormal_skin_adnexa	1.10602105
40	MP0006276_abnormal_autonomic_nervous	1.09316328
41	MP0000383_abnormal_hair_follicle	1.08609608
42	MP0001664_abnormal_digestion	1.04431414
43	MP0005171_absent_coat_pigmentation	1.02468541
44	MP0005645_abnormal_hypothalamus_physiol	0.99731334
45	MP0008872_abnormal_physiological_respon	0.98415777
46	MP0000579_abnormal_nail_morphology	0.98308400
47	MP0010368_abnormal_lymphatic_system	0.97040097
48	MP0004742_abnormal_vestibular_system	0.96434225
49	MP0005409_darkened_coat_color	0.95747366
50	MP0002272_abnormal_nervous_system	0.94441727
51	MP0003252_abnormal_bile_duct	0.88177955
52	MP0005174_abnormal_tail_pigmentation	0.87552826
53	MP0005167_abnormal_blood-brain_barrier	0.84949854
54	MP0001765_abnormal_ion_homeostasis	0.84863224
55	MP0005275_abnormal_skin_tensile	0.82200593
56	MP0010386_abnormal_urinary_bladder	0.81118126
57	MP0001970_abnormal_pain_threshold	0.79701741
58	MP0003828_pulmonary_edema	0.78841143
59	MP0003091_abnormal_cell_migration	0.77523217
60	MP0005670_abnormal_white_adipose	0.76844805
61	MP0002118_abnormal_lipid_homeostasis	0.76175137
62	MP0010234_abnormal_vibrissa_follicle	0.75738380
63	MP0004019_abnormal_vitamin_homeostasis	0.75512243
64	MP0001756_abnormal_urination	0.75243892
65	MP0002928_abnormal_bile_duct	0.74373435
66	MP0003953_abnormal_hormone_level	0.73736100
67	MP0002067_abnormal_sensory_capabilities	0.73038890
68	MP0002693_abnormal_pancreas_physiology	0.71870040
69	MP0002168_other_aberrant_phenotype	0.71834675
70	MP0004215_abnormal_myocardial_fiber	0.71242994
71	MP0009046_muscle_twitch	0.68945871
72	MP0008004_abnormal_stomach_pH	0.68097203
73	MP0003632_abnormal_nervous_system	0.65644636
74	MP0002796_impaired_skin_barrier	0.64778166
75	MP0000470_abnormal_stomach_morphology	0.64223800
76	MP0002229_neurodegeneration	0.63336373
77	MP0000015_abnormal_ear_pigmentation	0.63084963
78	MP0002877_abnormal_melanocyte_morpholog	0.62859981
79	MP0002078_abnormal_glucose_homeostasis	0.62709413
80	MP0005464_abnormal_platelet_physiology	0.58667380
81	MP0000230_abnormal_systemic_arterial	0.56500300
82	MP0001663_abnormal_digestive_system	0.56033803
83	MP0001502_abnormal_circadian_rhythm	0.54507643
84	MP0006138_congestive_heart_failure	0.54229589
85	MP0005452_abnormal_adipose_tissue	0.53914208
86	MP0003690_abnormal_glial_cell	0.53609644
87	MP0001486_abnormal_startle_reflex	0.51890552
88	MP0005266_abnormal_metabolism	0.51156228
89	MP0005410_abnormal_fertilization	0.51020769
90	MP0002075_abnormal_coat/hair_pigmentati	0.50166967
91	MP0000427_abnormal_hair_cycle	0.48667305
92	MP0010771_integument_phenotype	0.48218065
93	MP0003635_abnormal_synaptic_transmissio	0.47864112
94	MP0005085_abnormal_gallbladder_physiolo	0.47500180
95	MP0003633_abnormal_nervous_system	0.46672891
96	MP0002638_abnormal_pupillary_reflex	0.46329940
97	MP0003631_nervous_system_phenotype	0.46117385
98	MP0003941_abnormal_skin_development	0.46016330
99	MP0005248_abnormal_Harderian_gland	0.44892029
100	MP0001963_abnormal_hearing_physiology	0.44473461

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Steatorrhea (HP:0002570)	8.50168262
2	Fat malabsorption (HP:0002630)	6.37896708
3	Thoracolumbar scoliosis (HP:0002944)	5.30833201
4	Abnormality of the lumbar spine (HP:0100712)	5.23116868
5	Thoracic kyphosis (HP:0002942)	5.18576207
6	Deformed sella turcica (HP:0002681)	4.28096392
7	Congenital sensorineural hearing impairment (HP:0008527)	4.11998955
8	Hypoproteinemia (HP:0003075)	3.98301941
9	Palpebral edema (HP:0100540)	3.98258411
10	Broad ribs (HP:0000885)	3.72158975
11	Abnormality of the sella turcica (HP:0002679)	3.66155596
12	Clumsiness (HP:0002312)	3.61853024
13	Flat acetabular roof (HP:0003180)	3.47257170
14	Abnormality of the thoracic spine (HP:0100711)	3.41567679
15	J-shaped sella turcica (HP:0002680)	3.40901155
16	Carpal bone hypoplasia (HP:0001498)	3.38990020
17	Aortic regurgitation (HP:0001659)	3.16643703
18	Spontaneous hematomas (HP:0007420)	3.13688508
19	Vertebral arch anomaly (HP:0008438)	3.12741403
20	Genetic anticipation (HP:0003743)	3.01964402
21	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.93423765
22	Absent/shortened dynein arms (HP:0200106)	2.93423765
23	Exocrine pancreatic insufficiency (HP:0001738)	2.92282740
24	Decreased circulating renin level (HP:0003351)	2.85561975
25	Short 4th metacarpal (HP:0010044)	2.85288173
26	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.85288173
27	Neoplasm of the heart (HP:0100544)	2.83813955
28	Abnormality of chloride homeostasis (HP:0011422)	2.81537410
29	Protruding tongue (HP:0010808)	2.79259830
30	Bilateral sensorineural hearing impairment (HP:0008619)	2.78990247
31	Hyperkalemia (HP:0002153)	2.73421847
32	Thickened calvaria (HP:0002684)	2.63077592
33	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.63017425
34	Urethral obstruction (HP:0000796)	2.57196793
35	Abnormal pancreas size (HP:0012094)	2.56832318
36	Ileus (HP:0002595)	2.56624026
37	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.53574693
38	Esophageal varix (HP:0002040)	2.52119859
39	Diastasis recti (HP:0001540)	2.50209697
40	Abnormal ciliary motility (HP:0012262)	2.45723307
41	Abnormality of the right ventricle (HP:0001707)	2.42900951
42	Broad alveolar ridges (HP:0000187)	2.42810323
43	Portal hypertension (HP:0001409)	2.41456457
44	Short phalanx of the thumb (HP:0009660)	2.39051800
45	Fibular aplasia (HP:0002990)	2.34577377
46	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.31433215
47	Facial shape deformation (HP:0011334)	2.24440579
48	Potter facies (HP:0002009)	2.24440579
49	Corneal erosion (HP:0200020)	2.21103953
50	Abnormality of the hepatic vasculature (HP:0006707)	2.17611572
51	Onion bulb formation (HP:0003383)	2.14820995
52	Milia (HP:0001056)	2.12142858
53	Fair hair (HP:0002286)	2.10832264
54	Abnormality of the columella (HP:0009929)	2.09035560
55	Conjunctival telangiectasia (HP:0000524)	2.09022513
56	Progressive cerebellar ataxia (HP:0002073)	2.08020838
57	Craniofacial hyperostosis (HP:0004493)	2.06913555
58	Visual hallucinations (HP:0002367)	2.04318921
59	Abnormal hair laboratory examination (HP:0003328)	2.02980640
60	Central scotoma (HP:0000603)	2.02094417
61	Choroideremia (HP:0001139)	2.01751010
62	Abnormality of the odontoid process (HP:0003310)	2.01493962
63	Gaze-evoked nystagmus (HP:0000640)	2.00053453
64	Menorrhagia (HP:0000132)	1.99872025
65	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.93264614
66	Attenuation of retinal blood vessels (HP:0007843)	1.90291327
67	Periorbital edema (HP:0100539)	1.89941287
68	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	1.89187020
69	Asymmetry of the thorax (HP:0001555)	1.88628802
70	Increased mean platelet volume (HP:0011877)	1.88571964
71	Abnormality of the renal cortex (HP:0011035)	1.87359630
72	Mask-like facies (HP:0000298)	1.86706982
73	Facial diplegia (HP:0001349)	1.85706513
74	Abnormality of the 4th metacarpal (HP:0010012)	1.85062009
75	Prolonged bleeding time (HP:0003010)	1.84456385
76	Stereotypic behavior (HP:0000733)	1.84121961
77	Facial edema (HP:0000282)	1.83451417
78	Hyperventilation (HP:0002883)	1.82072870
79	Down-sloping shoulders (HP:0200021)	1.81659931
80	Hyperaldosteronism (HP:0000859)	1.81451015
81	Abnormality of renin-angiotensin system (HP:0000847)	1.79751836
82	Tracheomalacia (HP:0002779)	1.78720641
83	Bony spicule pigmentary retinopathy (HP:0007737)	1.78585931
84	Generalized hypopigmentation of hair (HP:0011358)	1.77969584
85	Oral leukoplakia (HP:0002745)	1.76860127
86	Cranial hyperostosis (HP:0004437)	1.76786611
87	Cystic liver disease (HP:0006706)	1.76680667
88	Dysmetric saccades (HP:0000641)	1.76614291
89	Increased cerebral lipofuscin (HP:0011813)	1.76483542
90	Hypophosphatemic rickets (HP:0004912)	1.74276560
91	Abnormality of potassium homeostasis (HP:0011042)	1.72214510
92	Flared iliac wings (HP:0002869)	1.72205427
93	Abolished electroretinogram (ERG) (HP:0000550)	1.71318812
94	Abnormality of the pons (HP:0007361)	1.69709833
95	Pili torti (HP:0003777)	1.69253394
96	Recurrent bronchitis (HP:0002837)	1.69194519
97	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.68678150
98	Nonprogressive disorder (HP:0003680)	1.67849289
99	Mucopolysacchariduria (HP:0008155)	1.67710495
100	Urinary glycosaminoglycan excretion (HP:0003541)	1.67710495

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	6.70598680
2	LATS1	5.12485293
3	BLK	3.90676419
4	LMTK2	3.81295749
5	FRK	3.64824795
6	NME1	2.78105641
7	MST1R	2.71026195
8	TIE1	2.59074509
9	NTRK3	2.30877382
10	NUAK1	1.96208943
11	MAP3K2	1.83298878
12	BMPR1B	1.80250871
13	ACVR1B	1.77215900
14	PIK3CG	1.75807931
15	MAP3K3	1.70211009
16	WNK4	1.66621079
17	EPHA3	1.62258015
18	EIF2AK3	1.62256729
19	MET	1.55852446
20	SGK2	1.51519621
21	MAP2K3	1.35441414
22	WNK1	1.32945296
23	PTK2B	1.30575461
24	IRAK1	1.29086837
25	EPHA2	1.26509080
26	SGK494	1.14393364
27	SGK223	1.14393364
28	GRK5	1.11893061
29	RET	1.01591002
30	TEC	1.00872632
31	TAOK3	1.00818712
32	FER	1.00605264
33	NLK	0.92004190
34	SGK3	0.89689663
35	MAP2K1	0.89600281
36	MAP3K7	0.89062431
37	GRK1	0.87916578
38	MAP2K2	0.82511904
39	DAPK2	0.81397035
40	MELK	0.80979223
41	CAMK4	0.80870140
42	STK3	0.80674871
43	DDR2	0.76517415
44	ADRBK1	0.75273464
45	FES	0.74714880
46	FGR	0.70828207
47	STK38L	0.69117132
48	GRK7	0.64966243
49	KDR	0.63846109
50	MAP3K1	0.63706800
51	MAP3K5	0.62884268
52	SGK1	0.61945172
53	ERBB2	0.61905233
54	ADRBK2	0.58226581
55	ITK	0.56643946
56	TGFBR1	0.56492599
57	TNIK	0.54239334
58	SYK	0.54178305
59	BTK	0.53767144
60	MAP3K9	0.53331365
61	FGFR3	0.52580850
62	PDK1	0.49365556
63	TRIB3	0.49092788
64	STK24	0.49010112
65	HCK	0.47728299
66	EPHB1	0.47227183
67	JAK1	0.45839815
68	MAP2K6	0.45723846
69	MATK	0.45594293
70	MUSK	0.44511020
71	DYRK1A	0.43133968
72	IKBKE	0.42566450
73	CDK12	0.41576561
74	TNK2	0.40237084
75	JAK2	0.39136723
76	PDGFRB	0.38664579
77	PKN2	0.38036681
78	BMX	0.37837641
79	MAP3K4	0.37059566
80	TGFBR2	0.36923830
81	MAP3K6	0.36163093
82	LYN	0.34334903
83	PIM1	0.33688672
84	IRAK4	0.32765611
85	RPS6KB2	0.32452301
86	MST4	0.31220897
87	PRKCE	0.28938818
88	PDPK1	0.27555373
89	MARK2	0.25867271
90	HIPK2	0.24755952
91	FGFR4	0.24445398
92	ZAP70	0.24002934
93	IGF1R	0.22736406
94	FYN	0.22461268
95	CSNK1A1	0.22186409
96	PRKAA2	0.22061368
97	IRAK2	0.21854333
98	INSR	0.21689496
99	CAMK2B	0.21422825
100	MAP2K4	0.20932474

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pancreatic secretion_Homo sapiens_hsa04972	8.54573620
2	Fat digestion and absorption_Homo sapiens_hsa04975	6.06339011
3	Protein digestion and absorption_Homo sapiens_hsa04974	4.97146750
4	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.75244548
5	Glycerolipid metabolism_Homo sapiens_hsa00561	3.69943862
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.73600389
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.30288487
8	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.13229629
9	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.83403646
10	Steroid biosynthesis_Homo sapiens_hsa00100	1.73964654
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.69251921
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.57596829
13	Histidine metabolism_Homo sapiens_hsa00340	1.49266865
14	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.45722667
15	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.39849130
16	Taste transduction_Homo sapiens_hsa04742	1.26653487
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.24123190
18	Renin-angiotensin system_Homo sapiens_hsa04614	1.22242703
19	Nicotine addiction_Homo sapiens_hsa05033	1.15547182
20	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.14682160
21	ABC transporters_Homo sapiens_hsa02010	1.11981374
22	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.98662339
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98269261
24	Salivary secretion_Homo sapiens_hsa04970	0.95720941
25	Morphine addiction_Homo sapiens_hsa05032	0.86416597
26	Selenocompound metabolism_Homo sapiens_hsa00450	0.82904440
27	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.82348596
28	Serotonergic synapse_Homo sapiens_hsa04726	0.81380691
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.75736352
30	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.73250009
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67608378
32	Glutamatergic synapse_Homo sapiens_hsa04724	0.66558929
33	Circadian entrainment_Homo sapiens_hsa04713	0.65730656
34	GABAergic synapse_Homo sapiens_hsa04727	0.65591767
35	Tryptophan metabolism_Homo sapiens_hsa00380	0.64825799
36	Bile secretion_Homo sapiens_hsa04976	0.64145246
37	Platelet activation_Homo sapiens_hsa04611	0.63738978
38	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.60077459
39	Calcium signaling pathway_Homo sapiens_hsa04020	0.57162580
40	Gastric acid secretion_Homo sapiens_hsa04971	0.56950422
41	Olfactory transduction_Homo sapiens_hsa04740	0.55783201
42	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.53243075
43	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.52938004
44	Insulin secretion_Homo sapiens_hsa04911	0.52335184
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51896731
46	GnRH signaling pathway_Homo sapiens_hsa04912	0.51800574
47	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.50493432
48	cAMP signaling pathway_Homo sapiens_hsa04024	0.49669737
49	Cocaine addiction_Homo sapiens_hsa05030	0.47593739
50	Renin secretion_Homo sapiens_hsa04924	0.47029960
51	Gap junction_Homo sapiens_hsa04540	0.46628768
52	Cholinergic synapse_Homo sapiens_hsa04725	0.45605561
53	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.42390871
54	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.40801428
55	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.40753615
56	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.39792564
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.37062504
58	Influenza A_Homo sapiens_hsa05164	0.36793346
59	Amphetamine addiction_Homo sapiens_hsa05031	0.35672232
60	ECM-receptor interaction_Homo sapiens_hsa04512	0.33187187
61	Non-small cell lung cancer_Homo sapiens_hsa05223	0.31426715
62	Long-term depression_Homo sapiens_hsa04730	0.30145424
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29611970
64	Ras signaling pathway_Homo sapiens_hsa04014	0.29481642
65	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.28978867
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.28804185
67	Phototransduction_Homo sapiens_hsa04744	0.28650703
68	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.28544772
69	Long-term potentiation_Homo sapiens_hsa04720	0.26384447
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.24757613
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.23983455
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.23938490
73	Rap1 signaling pathway_Homo sapiens_hsa04015	0.22739016
74	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.22465622
75	Vibrio cholerae infection_Homo sapiens_hsa05110	0.21904535
76	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.21561665
77	Retinol metabolism_Homo sapiens_hsa00830	0.21425018
78	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.21046892
79	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.20027333
80	Estrogen signaling pathway_Homo sapiens_hsa04915	0.19727226
81	Melanoma_Homo sapiens_hsa05218	0.18701381
82	Type II diabetes mellitus_Homo sapiens_hsa04930	0.17323933
83	Glutathione metabolism_Homo sapiens_hsa00480	0.16641830
84	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.16248537
85	Tight junction_Homo sapiens_hsa04530	0.16042150
86	MAPK signaling pathway_Homo sapiens_hsa04010	0.15408794
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.15118774
88	Glioma_Homo sapiens_hsa05214	0.15109364
89	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.13006246
90	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.12976279
91	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.10948232
92	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.10918334
93	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.10636540
94	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.10599771
95	Alcoholism_Homo sapiens_hsa05034	0.10348543
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.09280112
97	Prostate cancer_Homo sapiens_hsa05215	0.08544285
98	PPAR signaling pathway_Homo sapiens_hsa03320	0.08131724
99	Bladder cancer_Homo sapiens_hsa05219	0.07954084
100	Lysine degradation_Homo sapiens_hsa00310	0.07179946

USP17L9P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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