USP18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cellular response to type I interferon (GO:0071357)5.93707589
2* type I interferon signaling pathway (GO:0060337)5.93707589
3* response to type I interferon (GO:0034340)5.90990513
4cellular response to interferon-alpha (GO:0035457)5.53167363
5response to interferon-alpha (GO:0035455)5.27352794
6antigen processing and presentation of endogenous antigen (GO:0019883)5.18434720
7regulation of activation of Janus kinase activity (GO:0010533)5.17903389
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.12627953
9regulation of RIG-I signaling pathway (GO:0039535)5.11290489
10positive regulation of interferon-alpha production (GO:0032727)5.10326252
11regulation of vitamin D biosynthetic process (GO:0060556)4.98787657
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.92352528
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.92352528
14regulation of interferon-alpha production (GO:0032647)4.78909850
15regulation of T-helper 1 cell differentiation (GO:0045625)4.77130341
16negative regulation of viral genome replication (GO:0045071)4.75101514
17positive regulation of natural killer cell differentiation (GO:0032825)4.69037083
18regulation of chronic inflammatory response (GO:0002676)4.67729803
19T-helper 1 type immune response (GO:0042088)4.48588144
20neutrophil activation involved in immune response (GO:0002283)4.42207453
21regulation of viral genome replication (GO:0045069)4.40056005
22regulation of dendritic cell antigen processing and presentation (GO:0002604)4.36966660
23cellular response to interferon-beta (GO:0035458)4.35833817
24negative regulation of interleukin-12 production (GO:0032695)4.34370235
25* regulation of type I interferon-mediated signaling pathway (GO:0060338)4.30401617
26regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.28487905
27interferon-gamma-mediated signaling pathway (GO:0060333)4.27437409
28negative regulation of viral process (GO:0048525)4.25839165
29cellular response to exogenous dsRNA (GO:0071360)4.21674972
30positive regulation of type 2 immune response (GO:0002830)4.21273019
31positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.17366534
32positive regulation of interleukin-17 production (GO:0032740)4.14178326
33immunoglobulin mediated immune response (GO:0016064)4.12401353
34response to peptidoglycan (GO:0032494)4.10012351
35macrophage activation involved in immune response (GO:0002281)4.09288290
36positive regulation of interleukin-12 production (GO:0032735)4.04904598
37positive regulation of alpha-beta T cell proliferation (GO:0046641)4.02522591
38positive regulation of antigen processing and presentation (GO:0002579)4.01654736
39positive regulation of T-helper cell differentiation (GO:0045624)4.01408391
40response to interferon-beta (GO:0035456)4.00281968
41defense response to protozoan (GO:0042832)3.99059523
42natural killer cell mediated immunity (GO:0002228)3.98073385
43natural killer cell mediated cytotoxicity (GO:0042267)3.98073385
44negative regulation of interleukin-17 production (GO:0032700)3.96361074
45regulation of vitamin metabolic process (GO:0030656)3.96085176
46regulation of cytokine secretion involved in immune response (GO:0002739)3.88340976
47regulation of MHC class I biosynthetic process (GO:0045343)3.87226944
48positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.83150169
49negative regulation of cytokine production involved in immune response (GO:0002719)3.74794674
50regulation of interleukin-17 production (GO:0032660)3.73806454
51regulation of alpha-beta T cell proliferation (GO:0046640)3.73612196
52positive regulation of chemokine biosynthetic process (GO:0045080)3.71261628
53positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.69892683
54regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.68670832
55positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.68670832
56lipopolysaccharide-mediated signaling pathway (GO:0031663)3.65463717
57positive regulation of defense response to virus by host (GO:0002230)3.61076484
58regulation of memory T cell differentiation (GO:0043380)3.57236773
59granulocyte activation (GO:0036230)3.57046234
60positive regulation by symbiont of host defense response (GO:0052509)3.55713082
61modulation by symbiont of host defense response (GO:0052031)3.55713082
62modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.55713082
63modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.55713082
64positive regulation by organism of defense response of other organism involved in symbiotic interact3.55713082
65modulation by symbiont of host immune response (GO:0052553)3.55713082
66cellular response to interferon-gamma (GO:0071346)3.54280508
67cellular response to virus (GO:0098586)3.53658124
68positive regulation of interferon-beta production (GO:0032728)3.53639370
69defense response to virus (GO:0051607)3.53590765
70regulation of type 2 immune response (GO:0002828)3.52782879
71positive regulation of gamma-delta T cell activation (GO:0046645)3.52592077
72positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.51241501
73regulation of antigen processing and presentation (GO:0002577)3.50329505
74T cell migration (GO:0072678)3.49207847
75positive regulation of humoral immune response (GO:0002922)3.48583613
76positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.47352184
77neutrophil activation (GO:0042119)3.46033493
78regulation of interleukin-12 biosynthetic process (GO:0045075)3.44732127
79regulation of chemokine biosynthetic process (GO:0045073)3.43161161
80regulation of defense response to virus by host (GO:0050691)3.42806650
81NIK/NF-kappaB signaling (GO:0038061)3.41301410
82myeloid dendritic cell differentiation (GO:0043011)3.41133589
83B cell mediated immunity (GO:0019724)3.39667656
84response to protozoan (GO:0001562)3.37062976
85regulation of T-helper cell differentiation (GO:0045622)3.36786523
86cellular response to zinc ion (GO:0071294)3.36648634
87regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.32685512
88positive regulation of response to biotic stimulus (GO:0002833)3.31949872
89eosinophil chemotaxis (GO:0048245)3.31877527
90positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.31686711
91response to interferon-gamma (GO:0034341)3.30933892
92negative regulation of myeloid cell apoptotic process (GO:0033033)3.30213609
93natural killer cell activation involved in immune response (GO:0002323)3.29910498
94negative regulation of type I interferon production (GO:0032480)3.29318657
95regulation of immunoglobulin secretion (GO:0051023)3.29171593
96regulation of T-helper 2 cell differentiation (GO:0045628)3.28656844
97regulation of natural killer cell differentiation (GO:0032823)3.27317769
98lymphocyte chemotaxis (GO:0048247)3.25581872
99positive regulation of monocyte chemotaxis (GO:0090026)3.24747100
100negative thymic T cell selection (GO:0045060)3.24040734
101natural killer cell activation (GO:0030101)3.23745609
102regulation of podosome assembly (GO:0071801)3.22573915
103branching involved in labyrinthine layer morphogenesis (GO:0060670)3.21483063
104regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.20686668
105monocyte chemotaxis (GO:0002548)3.20228765
106regulation of T-helper 1 type immune response (GO:0002825)3.18294079
107positive regulation of heat generation (GO:0031652)3.18282339
108regulation of interferon-gamma biosynthetic process (GO:0045072)3.17290324
109modulation by symbiont of host cellular process (GO:0044068)3.16150707
110regulation of hypersensitivity (GO:0002883)3.15762503
111myeloid dendritic cell activation (GO:0001773)3.15587255
112regulation of fever generation (GO:0031620)3.15006052
113response to exogenous dsRNA (GO:0043330)3.14774465
114negative regulation of T cell mediated immunity (GO:0002710)3.14319256
115negative T cell selection (GO:0043383)3.13919763
116regulation of response to interferon-gamma (GO:0060330)3.10568288
117regulation of interferon-beta biosynthetic process (GO:0045357)3.10531370
118regulation of interleukin-12 production (GO:0032655)3.09977415
119negative regulation of defense response to virus (GO:0050687)3.08942813
120negative regulation of viral entry into host cell (GO:0046597)3.08369913
121regulation of interferon-beta production (GO:0032648)3.07771220
122negative regulation of viral release from host cell (GO:1902187)3.06893601
123regulation of T cell tolerance induction (GO:0002664)3.06437623
124positive regulation of T-helper 1 type immune response (GO:0002827)3.06152743
125hydrogen peroxide biosynthetic process (GO:0050665)3.05375712
126regulation of natural killer cell activation (GO:0032814)3.02729587
127positive regulation of isotype switching (GO:0045830)3.01422188
128response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.01320817
129response to host immune response (GO:0052572)3.01320817
130interferon-gamma secretion (GO:0072643)3.00279045
131negative regulation of production of molecular mediator of immune response (GO:0002701)2.99859318
132germinal center formation (GO:0002467)2.99438599
133positive regulation of toll-like receptor signaling pathway (GO:0034123)2.98314845
134negative regulation of multi-organism process (GO:0043901)2.96364062
135positive regulation of NF-kappaB import into nucleus (GO:0042346)2.94125880
136positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.92370741
137CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.91070781
138regulation of inflammatory response to antigenic stimulus (GO:0002861)2.91045300
139dendritic cell differentiation (GO:0097028)2.90977354
140positive regulation of cAMP-mediated signaling (GO:0043950)2.86446677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human9.41603847
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human7.01788877
3* IRF8_21731497_ChIP-ChIP_J774_Mouse6.90928458
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse6.15861772
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.30351204
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.55448383
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.89164785
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.48163734
9STAT4_19710469_ChIP-ChIP_TH1__Mouse3.40743028
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.21791015
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.14601634
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09320481
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06460866
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.92050457
15* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.64494329
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.38874769
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.34498305
18GATA1_22025678_ChIP-Seq_K562_Human2.24320586
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10500714
20MYB_26560356_Chip-Seq_TH2_Human1.92837688
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.87883848
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.80323999
23SPI1_23547873_ChIP-Seq_NB4_Human1.70483793
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63547711
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58281019
26RUNX_20019798_ChIP-Seq_JUKART_Human1.55509521
27MAF_26560356_Chip-Seq_TH1_Human1.54751283
28MYB_26560356_Chip-Seq_TH1_Human1.54577606
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54571619
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53288403
31* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46285414
32CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43513468
33PU_27001747_Chip-Seq_BMDM_Mouse1.43494331
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.35367120
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35190845
36GATA3_26560356_Chip-Seq_TH2_Human1.31442262
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31188749
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29077870
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27829435
40TFEB_21752829_ChIP-Seq_HELA_Human1.27624845
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26984166
42GATA3_27048872_Chip-Seq_THYMUS_Human1.25358338
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20897136
44* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19402453
45EGR1_19032775_ChIP-ChIP_M12_Human1.19323404
46* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18827291
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.17981013
48* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17924810
49* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16508784
50VDR_24787735_ChIP-Seq_THP-1_Human1.16026083
51RXR_22158963_ChIP-Seq_LIVER_Mouse1.15708650
52* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14007287
53* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13652774
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13007322
55VDR_24763502_ChIP-Seq_THP-1_Human1.10820440
56STAT1_20625510_ChIP-Seq_HELA_Human1.10690861
57ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08068250
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06976094
59SPI1_23127762_ChIP-Seq_K562_Human1.03975079
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03861343
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.02718212
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98968667
63PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98460270
64ELK3_25401928_ChIP-Seq_HUVEC_Human0.97560504
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97507741
66GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97495744
67LXR_22292898_ChIP-Seq_THP-1_Human0.97312382
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97173816
69GATA2_21666600_ChIP-Seq_HMVEC_Human0.96207771
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96139549
71* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92663702
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92080146
73MYC_22102868_ChIP-Seq_BL_Human0.91619439
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91097015
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89579792
76* SOX2_20726797_ChIP-Seq_SW620_Human0.87970253
77MAF_26560356_Chip-Seq_TH2_Human0.87002937
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86580376
79ELF1_20517297_ChIP-Seq_JURKAT_Human0.86052228
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85211403
81UTX_26944678_Chip-Seq_JUKART_Human0.85195651
82SCL_19346495_ChIP-Seq_HPC-7_Human0.83902416
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83240617
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82965402
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82912025
86BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81952665
87BCL6_27268052_Chip-Seq_Bcells_Human0.81621703
88PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79697549
89BCOR_27268052_Chip-Seq_Bcells_Human0.77348720
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77284463
91SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76543999
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75420016
93* LXR_22158963_ChIP-Seq_LIVER_Mouse0.75140009
94* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73856485
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73249947
96KDM2B_26808549_Chip-Seq_SUP-B15_Human0.72877018
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.72813325
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.71934860
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.71595820
100ELF1_17652178_ChIP-ChIP_JURKAT_Human0.66449777
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.63633306
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.62424559
103E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.61334605
104NRF2_20460467_ChIP-Seq_MEFs_Mouse0.60749085
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.60749085
106CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.60538465
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.60506461
108SMRT_27268052_Chip-Seq_Bcells_Human0.59468765
109VDR_21846776_ChIP-Seq_THP-1_Human0.59120675
110GATA1_19941827_ChIP-Seq_MEL_Mouse0.58858504
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.58553821
112CTCF_26484167_Chip-Seq_Bcells_Mouse0.58346723
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.57226617
114GATA1_22383799_ChIP-Seq_G1ME_Mouse0.56254221
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.53870077
116SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.53831644
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.53831644
118NOTCH1_21737748_ChIP-Seq_TLL_Human0.50295133
119TRIM28_21343339_ChIP-Seq_HEK293_Human0.50272278
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.49550242
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.49382987
122SPI1_20517297_ChIP-Seq_HL60_Human0.49254942
123CDX2_19796622_ChIP-Seq_MESCs_Mouse0.48772043
124CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.48569878
125NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.47993941
126PU1_27457419_Chip-Seq_LIVER_Mouse0.47556464
127JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.46586705

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.52001630
2* MP0009785_altered_susceptibility_to4.69016161
3MP0002148_abnormal_hypersensitivity_rea4.02477925
4MP0000685_abnormal_immune_system3.91419135
5MP0005671_abnormal_response_to3.84519716
6MP0003724_increased_susceptibility_to3.61471405
7MP0006082_CNS_inflammation3.41570711
8MP0001790_abnormal_immune_system3.34379570
9MP0005387_immune_system_phenotype3.34379570
10MP0005000_abnormal_immune_tolerance3.29923281
11MP0003436_decreased_susceptibility_to3.28327216
12* MP0005025_abnormal_response_to3.26042497
13MP0002419_abnormal_innate_immunity2.76407266
14MP0001800_abnormal_humoral_immune2.75676959
15* MP0002723_abnormal_immune_serum2.70009866
16MP0004510_myositis2.62270615
17MP0002452_abnormal_antigen_presenting2.61542833
18MP0002139_abnormal_hepatobiliary_system2.45176877
19MP0001819_abnormal_immune_cell2.35734466
20MP0002420_abnormal_adaptive_immunity2.30444740
21MP0002006_tumorigenesis2.25869924
22MP0002166_altered_tumor_susceptibility2.12700101
23MP0009764_decreased_sensitivity_to2.06724812
24MP0003763_abnormal_thymus_physiology1.97922065
25MP0001348_abnormal_lacrimal_gland1.96487708
26MP0004947_skin_inflammation1.95944751
27MP0005310_abnormal_salivary_gland1.95512647
28MP0002163_abnormal_gland_morphology1.91596905
29MP0002405_respiratory_system_inflammati1.87924043
30MP0003303_peritoneal_inflammation1.86973395
31MP0010155_abnormal_intestine_physiology1.85765049
32MP0001533_abnormal_skeleton_physiology1.84988785
33MP0005451_abnormal_body_composition1.84060483
34* MP0001845_abnormal_inflammatory_respons1.83218576
35MP0002138_abnormal_hepatobiliary_system1.80845750
36* MP0008469_abnormal_protein_level1.79767382
37MP0002254_reproductive_system_inflammat1.78589647
38MP0009333_abnormal_splenocyte_physiolog1.78402586
39* MP0000716_abnormal_immune_system1.75064926
40MP0001853_heart_inflammation1.73777470
41MP0003806_abnormal_nucleotide_metabolis1.72736453
42MP0003448_altered_tumor_morphology1.68136183
43* MP0002398_abnormal_bone_marrow1.67179409
44MP0002332_abnormal_exercise_endurance1.59634429
45MP0006054_spinal_hemorrhage1.57059664
46MP0005464_abnormal_platelet_physiology1.55545870
47MP0001346_abnormal_lacrimal_gland1.51339782
48MP0005058_abnormal_lysosome_morphology1.45963249
49MP0004782_abnormal_surfactant_physiolog1.39069184
50* MP0002429_abnormal_blood_cell1.35836830
51MP0000858_altered_metastatic_potential1.34005455
52MP0003186_abnormal_redox_activity1.33191321
53MP0002277_abnormal_respiratory_mucosa1.26605106
54MP0002722_abnormal_immune_system1.24323403
55MP0008004_abnormal_stomach_pH1.24108636
56MP0000689_abnormal_spleen_morphology1.22813312
57MP0003191_abnormal_cellular_cholesterol1.21628496
58MP0001873_stomach_inflammation1.21478096
59MP0002998_abnormal_bone_remodeling1.16749271
60MP0003075_altered_response_to1.12683302
61MP0009763_increased_sensitivity_to1.11077493
62MP0001545_abnormal_hematopoietic_system1.08900967
63MP0005397_hematopoietic_system_phenotyp1.08900967
64MP0003172_abnormal_lysosome_physiology1.08759010
65MP0000343_altered_response_to1.08462313
66MP0005379_endocrine/exocrine_gland_phen1.04921896
67MP0010307_abnormal_tumor_latency0.92661318
68MP0005166_decreased_susceptibility_to0.92190728
69MP0003690_abnormal_glial_cell0.88320480
70MP0009840_abnormal_foam_cell0.86465648
71MP0003045_fibrosis0.82527918
72MP0001881_abnormal_mammary_gland0.82380224
73MP0010386_abnormal_urinary_bladder0.82254190
74MP0000703_abnormal_thymus_morphology0.82117788
75MP0005390_skeleton_phenotype0.82107641
76MP0003656_abnormal_erythrocyte_physiolo0.80918757
77MP0009278_abnormal_bone_marrow0.80427506
78MP0002876_abnormal_thyroid_physiology0.76308771
79MP0002693_abnormal_pancreas_physiology0.75725478
80MP0005165_increased_susceptibility_to0.72530667
81MP0005164_abnormal_response_to0.70811117
82MP0000920_abnormal_myelination0.67762399
83MP0001542_abnormal_bone_strength0.66975818
84MP0003453_abnormal_keratinocyte_physiol0.66619876
85MP0002933_joint_inflammation0.65594226
86MP0000604_amyloidosis0.64559247
87MP0005167_abnormal_blood-brain_barrier0.64366385
88MP0003195_calcinosis0.64294913
89MP0001727_abnormal_embryo_implantation0.63920173
90MP0003091_abnormal_cell_migration0.63805285
91MP0009765_abnormal_xenobiotic_induced0.62627549
92MP0005647_abnormal_sex_gland0.62422789
93MP0001851_eye_inflammation0.62191571
94MP0008874_decreased_physiological_sensi0.62000330
95MP0002136_abnormal_kidney_physiology0.61181983
96MP0003866_abnormal_defecation0.61146970
97MP0005023_abnormal_wound_healing0.60622789
98MP0005266_abnormal_metabolism0.59854701
99MP0000249_abnormal_blood_vessel0.56460390
100MP0000569_abnormal_digit_pigmentation0.56246085
101MP0001663_abnormal_digestive_system0.55873123
102MP0005666_abnormal_adipose_tissue0.54617721
103MP0002877_abnormal_melanocyte_morpholog0.53424236
104MP0000627_abnormal_mammary_gland0.50607056
105MP0008057_abnormal_DNA_replication0.50339346
106MP0004808_abnormal_hematopoietic_stem0.48170422
107MP0000371_diluted_coat_color0.47691623
108MP0003300_gastrointestinal_ulcer0.46806809
109MP0003183_abnormal_peptide_metabolism0.46650219
110MP0002019_abnormal_tumor_incidence0.46272845
111MP0003566_abnormal_cell_adhesion0.45260823
112MP0009643_abnormal_urine_homeostasis0.43941618
113MP0003795_abnormal_bone_structure0.43693030
114MP0005319_abnormal_enzyme/_coenzyme0.43193296
115MP0005076_abnormal_cell_differentiation0.41966080
116MP0000609_abnormal_liver_physiology0.39659729
117MP0005408_hypopigmentation0.37018598
118MP0005584_abnormal_enzyme/coenzyme_acti0.36819275

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)6.72665831
2Eczematoid dermatitis (HP:0000976)6.08035548
3Recurrent abscess formation (HP:0002722)5.92845068
4Autoimmune thrombocytopenia (HP:0001973)5.63212431
5Elevated erythrocyte sedimentation rate (HP:0003565)5.57331540
6Recurrent bacterial skin infections (HP:0005406)5.50601313
7Abnormality of liposaccharide metabolism (HP:0010968)4.95610150
8Abnormality of glycosphingolipid metabolism (HP:0004343)4.95610150
9Abnormality of glycolipid metabolism (HP:0010969)4.95610150
10Recurrent gram-negative bacterial infections (HP:0005420)4.56521784
11Mediastinal lymphadenopathy (HP:0100721)4.49019629
12Gastrointestinal infarctions (HP:0005244)4.42346759
13Vasculitis (HP:0002633)4.32554831
14Abnormality of T cell number (HP:0011839)4.31053574
15Abnormality of macrophages (HP:0004311)4.25683095
16Autoimmune hemolytic anemia (HP:0001890)4.24935733
17Basal ganglia calcification (HP:0002135)4.20825152
18Recurrent fungal infections (HP:0002841)4.19779233
19Myositis (HP:0100614)4.16442670
20Hypergammaglobulinemia (HP:0010702)4.11807645
21Recurrent skin infections (HP:0001581)4.07571807
22Chronic otitis media (HP:0000389)4.07551280
23Orchitis (HP:0100796)4.01206838
24Chronic mucocutaneous candidiasis (HP:0002728)3.99492381
25Recurrent cutaneous fungal infections (HP:0011370)3.99492381
26Recurrent viral infections (HP:0004429)3.93460605
27Retrobulbar optic neuritis (HP:0100654)3.91565117
28Optic neuritis (HP:0100653)3.91565117
29Loss of speech (HP:0002371)3.81093464
30Disinhibition (HP:0000734)3.73162748
31T lymphocytopenia (HP:0005403)3.69653216
32Stomatitis (HP:0010280)3.50535448
33Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.44774190
34Gingivitis (HP:0000230)3.44213149
35Tetraparesis (HP:0002273)3.42565558
36Systemic lupus erythematosus (HP:0002725)3.40082481
37Agnosia (HP:0010524)3.38316420
38Recurrent bronchitis (HP:0002837)3.35029764
39Abnormality of T cells (HP:0002843)3.11344059
40Pulmonary infiltrates (HP:0002113)3.11129897
41Interstitial pulmonary disease (HP:0006530)3.08897501
42Chronic obstructive pulmonary disease (HP:0006510)3.05477249
43Obstructive lung disease (HP:0006536)3.05477249
44Nasal polyposis (HP:0100582)3.01474206
45Axonal loss (HP:0003447)3.01147654
46Periodontitis (HP:0000704)2.99276053
47Vacuolated lymphocytes (HP:0001922)2.99171422
48Leukocytosis (HP:0001974)2.95270372
49Hemoptysis (HP:0002105)2.94851397
50Dysostosis multiplex (HP:0000943)2.93008310
51Joint swelling (HP:0001386)2.92819555
52Pustule (HP:0200039)2.91134676
53Eosinophilia (HP:0001880)2.90804800
54Porencephaly (HP:0002132)2.84329201
55Gingival bleeding (HP:0000225)2.79792355
56IgG deficiency (HP:0004315)2.78915442
57Abnormality of eosinophils (HP:0001879)2.78084083
58Chronic diarrhea (HP:0002028)2.75366437
59Abnormality of the nasal mucosa (HP:0000433)2.73033194
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.70635340
61Arterial thrombosis (HP:0004420)2.64448151
62Meningitis (HP:0001287)2.63705969
63Anorexia (HP:0002039)2.60597375
64Urticaria (HP:0001025)2.59189493
65Thick nail (HP:0001805)2.59096428
66Polyneuropathy (HP:0001271)2.54316766
67Abnormality of T cell physiology (HP:0011840)2.53429307
68Recurrent pneumonia (HP:0006532)2.53326255
69Combined immunodeficiency (HP:0005387)2.52017226
70Severe combined immunodeficiency (HP:0004430)2.51887320
71IgA deficiency (HP:0002720)2.49832612
72Chronic sinusitis (HP:0011109)2.49001645
73Petechiae (HP:0000967)2.48185667
74Granulocytopenia (HP:0001913)2.44685444
75Thyroiditis (HP:0100646)2.43529520
76Nuclear cataract (HP:0100018)2.41318037
77Abnormality of aromatic amino acid family metabolism (HP:0004338)2.41209041
78Gastrointestinal stroma tumor (HP:0100723)2.37641974
79Cellulitis (HP:0100658)2.37526905
80Progressive neurologic deterioration (HP:0002344)2.37301627
81Keratoconjunctivitis (HP:0001096)2.36774690
82Glomerulonephritis (HP:0000099)2.36765693
83Pulmonary embolism (HP:0002204)2.34265762
84Recurrent lower respiratory tract infections (HP:0002783)2.33563974
85Keratoconjunctivitis sicca (HP:0001097)2.33092147
86Gangrene (HP:0100758)2.32982842
87Parakeratosis (HP:0001036)2.30036568
88Abnormality of polysaccharide metabolism (HP:0011012)2.29391921
89Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29391921
90Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29391921
91Thrombocytosis (HP:0001894)2.28584239
92Poor head control (HP:0002421)2.27455844
93Agammaglobulinemia (HP:0004432)2.27068504
94Abnormality of the pericardium (HP:0001697)2.24534250
95Purpura (HP:0000979)2.24419543
96Increased neuronal autofluorescent lipopigment (HP:0002074)2.22526370
97Abnormality of cells of the lymphoid lineage (HP:0012140)2.21529109
98Hematochezia (HP:0002573)2.19474720
99Abnormality of B cell number (HP:0010975)2.19304859
100Increased serum ferritin (HP:0003281)2.18992099
101Mucopolysacchariduria (HP:0008155)2.18886228
102Urinary glycosaminoglycan excretion (HP:0003541)2.18886228
103Abnormality of the pleura (HP:0002103)2.18669513
104Prostate neoplasm (HP:0100787)2.17061790
105Amaurosis fugax (HP:0100576)2.15056770
106Chest pain (HP:0100749)2.14970924
107B lymphocytopenia (HP:0010976)2.14764572
108Cleft eyelid (HP:0000625)2.14700632
109Nausea (HP:0002018)2.11969079
110Upper motor neuron abnormality (HP:0002127)2.11302070
111Osteolytic defects of the hand bones (HP:0009699)2.10920241
112Osteolytic defects of the phalanges of the hand (HP:0009771)2.10920241
113Increased IgE level (HP:0003212)2.10119314
114Personality changes (HP:0000751)2.09515237
115Hypoplasia of the thymus (HP:0000778)2.09170813
116Increased cerebral lipofuscin (HP:0011813)2.07438019
117Skin ulcer (HP:0200042)2.06798754
118Emphysema (HP:0002097)2.05051888
119Hepatosplenomegaly (HP:0001433)2.04983593
120Arthralgia (HP:0002829)2.04660351
121Memory impairment (HP:0002354)2.04338715
122Premature loss of primary teeth (HP:0006323)2.03398271
123Diminished motivation (HP:0000745)2.02771041
124Abnormality of the basal ganglia (HP:0002134)2.01805611
125Generalized aminoaciduria (HP:0002909)2.01649113
126Vertigo (HP:0002321)2.01608190
127Lymphopenia (HP:0001888)2.01551376
128Abnormality of the endocardium (HP:0004306)2.00632959
129Progressive external ophthalmoplegia (HP:0000590)2.00567724
130Vertebral compression fractures (HP:0002953)2.00503034
131Abnormality of the prostate (HP:0008775)1.99912704
132Glomerulopathy (HP:0100820)1.99806249
133Myocardial infarction (HP:0001658)1.98463456
134Inflammation of the large intestine (HP:0002037)1.97775496
135Encephalitis (HP:0002383)1.97721703
136Cheilitis (HP:0100825)1.95915973
137Keratitis (HP:0000491)1.94801360
138Apathy (HP:0000741)1.94627241
139Osteomyelitis (HP:0002754)1.94288120
140Hypertensive crisis (HP:0100735)1.93645836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.29767521
2TYK24.11287703
3IKBKE3.83412025
4TBK13.79454503
5JAK33.75263267
6TXK3.63924847
7PBK3.17386238
8IRAK43.04641816
9JAK12.87357208
10FGFR42.83552996
11IKBKB2.61912556
12MAP4K12.50714734
13KIT2.36722062
14MAP3K132.31096760
15TAOK22.21832131
16RIPK42.20064732
17BLK2.17912618
18PRPF4B1.96894948
19IRAK31.90491109
20PIM21.88430671
21BMPR21.79955658
22CHUK1.79834456
23DDR21.76992632
24NEK91.72334332
25FGFR31.72139172
26ZAP701.65136074
27MST41.62077083
28MAP3K31.58914770
29CSK1.53983120
30SYK1.46394542
31EPHA31.39757165
32ERN11.39566593
33EPHB11.31529176
34EIF2AK21.30365348
35BTK1.19494234
36MAP2K31.17642553
37IRAK11.15022587
38TAOK11.14089787
39LCK1.13524231
40HCK1.12243253
41TAOK31.12140092
42MAP3K111.11801812
43JAK21.08565484
44TEC1.05367116
45CDC42BPA0.96889022
46RPS6KA40.95523368
47SMG10.94323206
48LYN0.94301523
49BCR0.94186747
50ARAF0.88992778
51PIM10.84455421
52ADRBK20.82654535
53NLK0.81712234
54HIPK20.81192577
55ERBB30.76960714
56SIK30.76613378
57ITK0.75867501
58CSF1R0.75814493
59STK40.73025356
60PRKCD0.72209427
61MAP2K60.69100090
62ABL20.68760405
63TRPM70.66711873
64PRKCQ0.65574989
65TESK10.64423805
66MST1R0.62316405
67CLK10.59859799
68RIPK10.59235466
69MAP3K120.58193552
70TLK10.56960110
71TNK20.56958674
72NME20.56372900
73BMX0.56017779
74IRAK20.55788682
75MAPKAPK30.55497007
76STK100.54119242
77MARK30.51599590
78MAP3K50.51299227
79MATK0.51096555
80MAPK110.49173147
81ABL10.47019940
82TESK20.46065535
83STK240.45585382
84FLT30.44584263
85EGFR0.42782449
86SCYL20.41968777
87TRIB30.41381119
88MAPKAPK20.41340210
89RPS6KA50.40464269
90KDR0.40439339
91ACVR1B0.39960468
92PTK60.39498424
93PAK40.39445616
94PIK3CG0.39145987
95FES0.37647155
96MOS0.35897824
97IGF1R0.34838263
98LRRK20.34709077
99MAP3K10.34056801
100MELK0.32811101
101BMPR1B0.31715100
102NUAK10.30937557
103EIF2AK30.30510559
104GRK70.27840150
105FGR0.27598098
106BCKDK0.25347452
107YES10.24558240
108PDK10.23872029
109PKN10.23869117
110MAPK70.23137335
111RPS6KA10.20801020
112RPS6KB20.20070786
113TGFBR20.19671255
114SIK10.19479268
115LATS20.18984370
116INSR0.18027359
117DAPK30.17898671
118MAPK40.16691649
119SRC0.16186945
120FYN0.15760043
121MAP3K80.15379303
122EIF2AK10.13236296
123MAPK30.13217292
124GRK60.12045992
125TIE10.10354149
126TGFBR10.09721775
127ATR0.08180871
128NEK60.07872210
129CDK40.07633176
130PLK40.07482842
131RPS6KA60.06977430

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.63261243
2Graft-versus-host disease_Homo sapiens_hsa053324.55773553
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.39876954
4Type I diabetes mellitus_Homo sapiens_hsa049403.07461791
5Leishmaniasis_Homo sapiens_hsa051402.96908315
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.90247848
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.84941658
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.80407963
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.73725192
10Measles_Homo sapiens_hsa051622.73680798
11Autoimmune thyroid disease_Homo sapiens_hsa053202.46111574
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.39408636
13Influenza A_Homo sapiens_hsa051642.27302104
14Primary immunodeficiency_Homo sapiens_hsa053402.21205105
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.15869370
16Legionellosis_Homo sapiens_hsa051342.14642401
17Herpes simplex infection_Homo sapiens_hsa051682.14368301
18African trypanosomiasis_Homo sapiens_hsa051432.13013200
19Staphylococcus aureus infection_Homo sapiens_hsa051502.03078561
20Malaria_Homo sapiens_hsa051441.97558708
21Pertussis_Homo sapiens_hsa051331.95245665
22Rheumatoid arthritis_Homo sapiens_hsa053231.91241503
23Asthma_Homo sapiens_hsa053101.89039228
24Antigen processing and presentation_Homo sapiens_hsa046121.88714332
25TNF signaling pathway_Homo sapiens_hsa046681.82979215
26Osteoclast differentiation_Homo sapiens_hsa043801.81137910
27Toxoplasmosis_Homo sapiens_hsa051451.67775096
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.67116112
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.59916829
30Tuberculosis_Homo sapiens_hsa051521.58019687
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.52847239
32Viral myocarditis_Homo sapiens_hsa054161.52305816
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36992698
34Salmonella infection_Homo sapiens_hsa051321.29974258
35Chemokine signaling pathway_Homo sapiens_hsa040621.29290950
36Apoptosis_Homo sapiens_hsa042101.27447240
37Hematopoietic cell lineage_Homo sapiens_hsa046401.26806646
38Sulfur metabolism_Homo sapiens_hsa009201.25277829
39Hepatitis C_Homo sapiens_hsa051601.20300305
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05700405
41Proteasome_Homo sapiens_hsa030501.05596060
42Hepatitis B_Homo sapiens_hsa051610.98490730
43T cell receptor signaling pathway_Homo sapiens_hsa046600.96314637
44B cell receptor signaling pathway_Homo sapiens_hsa046620.95636766
45Shigellosis_Homo sapiens_hsa051310.88626258
46Lysosome_Homo sapiens_hsa041420.86695287
47Phagosome_Homo sapiens_hsa041450.86165388
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74280589
49Prolactin signaling pathway_Homo sapiens_hsa049170.68928111
50Amoebiasis_Homo sapiens_hsa051460.67652298
51Caffeine metabolism_Homo sapiens_hsa002320.66147816
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60906228
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60204286
54Prion diseases_Homo sapiens_hsa050200.58863857
55Folate biosynthesis_Homo sapiens_hsa007900.58333648
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56914630
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55894510
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.55574083
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51599846
60Epstein-Barr virus infection_Homo sapiens_hsa051690.49477408
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47229094
62Other glycan degradation_Homo sapiens_hsa005110.47188558
63Bladder cancer_Homo sapiens_hsa052190.46916772
64Sphingolipid metabolism_Homo sapiens_hsa006000.44070432
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.43433137
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41631611
67Collecting duct acid secretion_Homo sapiens_hsa049660.40102942
68Acute myeloid leukemia_Homo sapiens_hsa052210.36739987
69Galactose metabolism_Homo sapiens_hsa000520.35708868
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.35702740
71Complement and coagulation cascades_Homo sapiens_hsa046100.35513534
72Viral carcinogenesis_Homo sapiens_hsa052030.35138428
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34922275
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33267444
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33091569
76p53 signaling pathway_Homo sapiens_hsa041150.30964569
77Fructose and mannose metabolism_Homo sapiens_hsa000510.27860377
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27667796
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25917115
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25169011
81HTLV-I infection_Homo sapiens_hsa051660.24680756
82Small cell lung cancer_Homo sapiens_hsa052220.23805832
83Sulfur relay system_Homo sapiens_hsa041220.23785938
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21919092
85Platelet activation_Homo sapiens_hsa046110.21841823
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19984406
87HIF-1 signaling pathway_Homo sapiens_hsa040660.18792624
88Pancreatic cancer_Homo sapiens_hsa052120.18703540
89Dorso-ventral axis formation_Homo sapiens_hsa043200.17150084
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16253459
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15596599
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15419736
93Regulation of autophagy_Homo sapiens_hsa041400.13840474
94Systemic lupus erythematosus_Homo sapiens_hsa053220.12773624
95Notch signaling pathway_Homo sapiens_hsa043300.12042106
96Phenylalanine metabolism_Homo sapiens_hsa003600.10353543
97ABC transporters_Homo sapiens_hsa020100.10013378
98Vibrio cholerae infection_Homo sapiens_hsa051100.09541431
99Chronic myeloid leukemia_Homo sapiens_hsa052200.08404928
100Mineral absorption_Homo sapiens_hsa049780.07866581
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.07390603
102PPAR signaling pathway_Homo sapiens_hsa033200.07104393
103Type II diabetes mellitus_Homo sapiens_hsa049300.04594161
104Glutathione metabolism_Homo sapiens_hsa004800.04091096
105Tryptophan metabolism_Homo sapiens_hsa003800.03335329
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.02909139
107Insulin resistance_Homo sapiens_hsa049310.00345120
108FoxO signaling pathway_Homo sapiens_hsa040680.00341792
109VEGF signaling pathway_Homo sapiens_hsa04370-0.0705252
110Histidine metabolism_Homo sapiens_hsa00340-0.0620457
111Proteoglycans in cancer_Homo sapiens_hsa05205-0.0408275
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0351854
113Primary bile acid biosynthesis_Homo sapiens_hsa00120-0.0285832
114Peroxisome_Homo sapiens_hsa04146-0.0270946
115Regulation of actin cytoskeleton_Homo sapiens_hsa04810-0.0085532
116Sphingolipid signaling pathway_Homo sapiens_hsa04071-0.0068498

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