USP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)5.13788136
2acrosome reaction (GO:0007340)4.57369011
3regulation of acrosome reaction (GO:0060046)4.54920711
4cilium or flagellum-dependent cell motility (GO:0001539)4.51591156
5fusion of sperm to egg plasma membrane (GO:0007342)4.38259559
6axonemal dynein complex assembly (GO:0070286)4.32417677
7regulation of female gonad development (GO:2000194)4.24996263
8motile cilium assembly (GO:0044458)4.18775436
9epithelial cilium movement (GO:0003351)4.17466488
10regulation of meiosis I (GO:0060631)4.02323897
11cardiac myofibril assembly (GO:0055003)4.02018603
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.01905003
13negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.98105573
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.86641271
15sarcomere organization (GO:0045214)3.85887095
16negative regulation of inclusion body assembly (GO:0090084)3.84771551
17regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.84058662
18cell wall macromolecule catabolic process (GO:0016998)3.83555849
19cell wall macromolecule metabolic process (GO:0044036)3.83555849
20multicellular organism reproduction (GO:0032504)3.83074426
21regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.80590579
22myofibril assembly (GO:0030239)3.79258539
23cilium movement (GO:0003341)3.78658910
24regulation of cilium movement (GO:0003352)3.78459855
25plasma membrane fusion (GO:0045026)3.76332688
26oocyte development (GO:0048599)3.75666909
27amino-acid betaine transport (GO:0015838)3.72012492
28carnitine transport (GO:0015879)3.72012492
29regulation of skeletal muscle contraction (GO:0014819)3.71887396
30regulation of DNA methylation (GO:0044030)3.70445163
31actin-myosin filament sliding (GO:0033275)3.69465192
32muscle filament sliding (GO:0030049)3.69465192
33single strand break repair (GO:0000012)3.68104699
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.68061006
35regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.66211884
36cellular ketone body metabolic process (GO:0046950)3.65927652
37retinal cone cell development (GO:0046549)3.65926041
38sarcoplasmic reticulum calcium ion transport (GO:0070296)3.64793327
39protein K6-linked ubiquitination (GO:0085020)3.61980268
40regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.60615126
41sperm capacitation (GO:0048240)3.60455416
42carnitine transmembrane transport (GO:1902603)3.59413013
43negative regulation of potassium ion transmembrane transport (GO:1901380)3.57559545
44meiotic cell cycle (GO:0051321)3.55037068
45negative regulation of hormone biosynthetic process (GO:0032353)3.54223796
46piRNA metabolic process (GO:0034587)3.53830669
47tricarboxylic acid cycle (GO:0006099)3.51026604
48regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.47760085
49cardiac muscle contraction (GO:0060048)3.46109050
50positive regulation of meiosis (GO:0045836)3.45630082
51DNA methylation involved in gamete generation (GO:0043046)3.42640897
52acrosome assembly (GO:0001675)3.41140300
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40064124
54regulation of actin filament-based movement (GO:1903115)3.39966891
55carnitine shuttle (GO:0006853)3.39249577
56spermatid development (GO:0007286)3.38657133
57organic cation transport (GO:0015695)3.37888394
58sperm-egg recognition (GO:0035036)3.33606190
59positive regulation of meiotic cell cycle (GO:0051446)3.29455398
60regulation of cell communication by electrical coupling (GO:0010649)3.29139824
61regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.27800826
62regulation of membrane repolarization (GO:0060306)3.24247074
63striated muscle contraction (GO:0006941)3.22409945
64cell communication by electrical coupling (GO:0010644)3.21045143
65regulation of type B pancreatic cell apoptotic process (GO:2000674)3.18545066
66ventricular cardiac muscle cell action potential (GO:0086005)3.17494058
67ketone body metabolic process (GO:1902224)3.16631450
68regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.16270921
69negative regulation of hormone metabolic process (GO:0032351)3.13518269
70actin-mediated cell contraction (GO:0070252)3.12347796
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.10132575
72reproduction (GO:0000003)3.09604813
73glycine transport (GO:0015816)3.09170803
74cell communication involved in cardiac conduction (GO:0086065)3.08221498
75regulation of acyl-CoA biosynthetic process (GO:0050812)3.08060965
76regulation of inclusion body assembly (GO:0090083)3.07131028
77Golgi to endosome transport (GO:0006895)3.02891570
78protein targeting to Golgi (GO:0000042)3.02786109
79membrane depolarization during action potential (GO:0086010)3.01539386
80positive regulation of histone H3-K4 methylation (GO:0051571)2.99890633
81aspartate family amino acid catabolic process (GO:0009068)2.99751322
82calcium ion-dependent exocytosis (GO:0017156)2.99219060
83positive regulation of gastrulation (GO:2000543)2.98956774
84glycogen catabolic process (GO:0005980)2.97809982
85quaternary ammonium group transport (GO:0015697)2.95463325
86cell-cell recognition (GO:0009988)2.95160159
87somite rostral/caudal axis specification (GO:0032525)2.92273421
88centriole assembly (GO:0098534)2.91407382
89retrograde transport, vesicle recycling within Golgi (GO:0000301)2.91058272
90actin filament-based movement (GO:0030048)2.89632919
91NADH metabolic process (GO:0006734)2.89215861
92binding of sperm to zona pellucida (GO:0007339)2.85993226
93fatty acid transmembrane transport (GO:1902001)2.85702083
94cellular potassium ion homeostasis (GO:0030007)2.85499618
95detection of calcium ion (GO:0005513)2.84823216
96regulation of hexokinase activity (GO:1903299)2.82796057
97regulation of glucokinase activity (GO:0033131)2.82796057
98establishment of protein localization to Golgi (GO:0072600)2.81642015
99negative regulation of cytosolic calcium ion concentration (GO:0051481)2.81411048
100regulation of calcium ion transmembrane transporter activity (GO:1901019)2.81106326
101regulation of calcium ion transmembrane transport (GO:1903169)2.81106326
102regulation of relaxation of muscle (GO:1901077)2.80750392
103calcium ion import (GO:0070509)2.79957613
104male meiosis (GO:0007140)2.79328932
105cardiac muscle hypertrophy (GO:0003300)2.77458155
106plasma membrane repair (GO:0001778)2.77275887
107regulation of striated muscle contraction (GO:0006942)2.76213581
108positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.76111361
109regulation of secondary heart field cardioblast proliferation (GO:0003266)2.76049691
110regulation of cardioblast proliferation (GO:0003264)2.76049691
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.75275596
112glucan catabolic process (GO:0009251)2.74609721
113regulation of coenzyme metabolic process (GO:0051196)2.74141933
114regulation of cofactor metabolic process (GO:0051193)2.74141933
115sodium ion export (GO:0071436)2.71877537
116fertilization (GO:0009566)2.70720899
117single fertilization (GO:0007338)2.70615866
118striated muscle hypertrophy (GO:0014897)2.70211865
119creatine metabolic process (GO:0006600)2.69703248
120muscle hypertrophy in response to stress (GO:0003299)2.68670116
121cardiac muscle adaptation (GO:0014887)2.68670116
122cardiac muscle hypertrophy in response to stress (GO:0014898)2.68670116
123potassium ion import (GO:0010107)2.68401692
124water-soluble vitamin biosynthetic process (GO:0042364)2.67426257
125adult heart development (GO:0007512)2.66751202
126regulation of cardiac muscle cell contraction (GO:0086004)2.66311943
127skeletal muscle contraction (GO:0003009)2.65890953
128regulation of steroid hormone biosynthetic process (GO:0090030)2.64650842
129cardiac muscle cell development (GO:0055013)2.64505506
130female gamete generation (GO:0007292)2.64006051
131nitric oxide mediated signal transduction (GO:0007263)2.63480924
132left/right pattern formation (GO:0060972)2.63168915
133epithelial cell fate commitment (GO:0072148)2.62927007
134regulation of steroid hormone secretion (GO:2000831)2.62694547
135centriole replication (GO:0007099)2.62371193
136actomyosin structure organization (GO:0031032)2.62318664
137relaxation of muscle (GO:0090075)2.62315184
138synaptonemal complex organization (GO:0070193)2.62072183
139neuron fate determination (GO:0048664)2.60976135
140chemosensory behavior (GO:0007635)2.59608296
141muscle contraction (GO:0006936)2.59183236
142cardiac muscle cell action potential (GO:0086001)2.59152611
143positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.58878176
144glycolytic process (GO:0006096)2.58685360
145relaxation of cardiac muscle (GO:0055119)2.57955835
146regulation of voltage-gated calcium channel activity (GO:1901385)2.57810726
147response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.57203509
148insulin secretion (GO:0030073)2.56823855
149regulation of sarcomere organization (GO:0060297)2.55048851
150neuronal action potential propagation (GO:0019227)2.54103922
151cardiac muscle cell action potential involved in contraction (GO:0086002)2.50659958
152cardiac conduction (GO:0061337)2.49457608
153lysine metabolic process (GO:0006553)2.48203390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.98724199
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.64350420
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.50087683
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.46412435
5GBX2_23144817_ChIP-Seq_PC3_Human2.27983297
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19714420
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.05580175
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04588952
9VDR_22108803_ChIP-Seq_LS180_Human1.99645370
10DROSHA_22980978_ChIP-Seq_HELA_Human1.83867991
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76590860
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76233416
13EZH2_27294783_Chip-Seq_ESCs_Mouse1.76195048
14EP300_21415370_ChIP-Seq_HL-1_Mouse1.74016034
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73104122
16MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72678731
17SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66993414
18REST_21632747_ChIP-Seq_MESCs_Mouse1.66911563
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58067732
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51455837
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50312870
22ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47947017
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47218128
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47218128
25* RARB_27405468_Chip-Seq_BRAIN_Mouse1.45574421
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45089510
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.43443575
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40122515
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38304695
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35675215
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.35456263
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35419619
33ZNF274_21170338_ChIP-Seq_K562_Hela1.34981364
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.34854164
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33125958
36* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32833330
37HTT_18923047_ChIP-ChIP_STHdh_Human1.32526086
38MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30541125
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29963240
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28814082
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.26949613
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23648131
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23507267
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23375499
45* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21636119
46SOX2_19829295_ChIP-Seq_ESCs_Human1.21334684
47NANOG_19829295_ChIP-Seq_ESCs_Human1.21334684
48TAF15_26573619_Chip-Seq_HEK293_Human1.20520034
49* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20372199
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.18824733
51TBX20_22080862_ChIP-Seq_HEART_Mouse1.18469091
52TBX20_22328084_ChIP-Seq_HEART_Mouse1.18469091
53RUNX2_22187159_ChIP-Seq_PCA_Human1.17616679
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17132822
55* CDX2_22108803_ChIP-Seq_LS180_Human1.15523262
56FUS_26573619_Chip-Seq_HEK293_Human1.14864421
57ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14476978
58LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13260260
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12391011
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12170098
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.11725195
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11627436
63FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10356549
64CBP_21632823_ChIP-Seq_H3396_Human1.08750176
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.08567067
66CTCF_27219007_Chip-Seq_Bcells_Human1.08421012
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.06333769
68TP53_22573176_ChIP-Seq_HFKS_Human1.05819195
69BCAT_22108803_ChIP-Seq_LS180_Human1.05390351
70AR_21572438_ChIP-Seq_LNCaP_Human1.05174842
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04727009
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04042332
73NANOG_20526341_ChIP-Seq_ESCs_Human1.03950121
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.01943847
75TBL1_22424771_ChIP-Seq_293T_Human1.01804841
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01627703
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01504271
78NFYB_21822215_ChIP-Seq_K562_Human1.00788055
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.00614030
80EZH2_27294783_Chip-Seq_NPCs_Mouse0.99539135
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99334367
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99334367
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98981702
84CBP_20019798_ChIP-Seq_JUKART_Human0.98981702
85AR_25329375_ChIP-Seq_VCAP_Human0.98937930
86* SMAD3_21741376_ChIP-Seq_HESCs_Human0.98898911
87* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98160116
88TCF4_22108803_ChIP-Seq_LS180_Human0.97902214
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97833436
90KDM2B_26808549_Chip-Seq_REH_Human0.97743948
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97624366
92AHR_22903824_ChIP-Seq_MCF-7_Human0.97539755
93* SMAD4_21741376_ChIP-Seq_EPCs_Human0.96653352
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96181075
95PHF8_20622853_ChIP-Seq_HELA_Human0.96155300
96FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96152929
97TCF4_23295773_ChIP-Seq_U87_Human0.95389958
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95279328
99WDR5_24793694_ChIP-Seq_LNCAP_Human0.95249533
100STAT3_23295773_ChIP-Seq_U87_Human0.94417195
101ESR1_20079471_ChIP-ChIP_T-47D_Human0.94374373
102SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93985310
103TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93946326
104FLI1_21867929_ChIP-Seq_TH2_Mouse0.93592034
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92897151
106HNFA_21074721_ChIP-Seq_CACO-2_Human0.92698630
107* FOXH1_21741376_ChIP-Seq_EPCs_Human0.92257888
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92090269
109SOX2_21211035_ChIP-Seq_LN229_Gbm0.91760266
110RBPJ_21746931_ChIP-Seq_IB4_Human0.91436895
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91157431
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.90822609
113PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.90619217
114ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90546846
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89375902
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88838268
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88587029
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87997602
119P300_19829295_ChIP-Seq_ESCs_Human0.87591966
120* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87553861
121RING1B_27294783_Chip-Seq_ESCs_Mouse0.86706268
122ARNT_22903824_ChIP-Seq_MCF-7_Human0.86553014
123NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85898077
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85855513
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85697445
126LXR_22158963_ChIP-Seq_LIVER_Mouse0.85474674
127AR_19668381_ChIP-Seq_PC3_Human0.85302415
128TAL1_26923725_Chip-Seq_HPCs_Mouse0.85192932
129STAT1_17558387_ChIP-Seq_HELA_Human0.84708566
130* SMAD4_21741376_ChIP-Seq_HESCs_Human0.84670845
131POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84551745
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84016415
133ER_23166858_ChIP-Seq_MCF-7_Human0.83832329
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83748845
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.83211485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.19163019
2MP0005410_abnormal_fertilization4.68552185
3MP0002837_dystrophic_cardiac_calcinosis4.24827877
4MP0000751_myopathy3.77616629
5MP0004145_abnormal_muscle_electrophysio3.21593660
6MP0003718_maternal_effect3.20092024
7MP0000749_muscle_degeneration3.10990377
8MP0004036_abnormal_muscle_relaxation3.03092829
9MP0010234_abnormal_vibrissa_follicle2.95527716
10MP0004215_abnormal_myocardial_fiber2.91391309
11MP0004084_abnormal_cardiac_muscle2.80754159
12MP0004859_abnormal_synaptic_plasticity2.56112433
13MP0005551_abnormal_eye_electrophysiolog2.20897084
14MP0005670_abnormal_white_adipose2.16116274
15MP0003283_abnormal_digestive_organ2.13876728
16MP0005330_cardiomyopathy2.04745110
17MP0005620_abnormal_muscle_contractility2.03237631
18MP0004087_abnormal_muscle_fiber1.95345801
19MP0002822_catalepsy1.92966492
20MP0004270_analgesia1.92676390
21MP0004233_abnormal_muscle_weight1.89982271
22MP0003950_abnormal_plasma_membrane1.87180548
23MP0003880_abnormal_central_pattern1.86591108
24MP0004130_abnormal_muscle_cell1.85537307
25MP0002106_abnormal_muscle_physiology1.83445028
26MP0002269_muscular_atrophy1.83165204
27MP0009046_muscle_twitch1.77044630
28MP0003698_abnormal_male_reproductive1.75023127
29MP0002972_abnormal_cardiac_muscle1.73052543
30MP0003635_abnormal_synaptic_transmissio1.72544852
31MP0003137_abnormal_impulse_conducting1.72158326
32MP0004484_altered_response_of1.71638922
33MP0004043_abnormal_pH_regulation1.64471043
34MP0000747_muscle_weakness1.63085924
35MP0000013_abnormal_adipose_tissue1.60859899
36MP0006292_abnormal_olfactory_placode1.59258706
37MP0009745_abnormal_behavioral_response1.57229456
38MP0005379_endocrine/exocrine_gland_phen1.52851536
39MP0004085_abnormal_heartbeat1.49868951
40MP0005369_muscle_phenotype1.49462047
41MP0000750_abnormal_muscle_regeneration1.48461128
42MP0005360_urolithiasis1.41403476
43MP0005395_other_phenotype1.41096216
44MP0002064_seizures1.40423666
45MP0000759_abnormal_skeletal_muscle1.40136446
46MP0002638_abnormal_pupillary_reflex1.39511163
47MP0003011_delayed_dark_adaptation1.38520677
48MP0005645_abnormal_hypothalamus_physiol1.38443910
49MP0001944_abnormal_pancreas_morphology1.37463320
50MP0001929_abnormal_gametogenesis1.36443634
51MP0002272_abnormal_nervous_system1.36233108
52MP0003329_amyloid_beta_deposits1.35747206
53MP0005666_abnormal_adipose_tissue1.34697085
54MP0002063_abnormal_learning/memory/cond1.34290924
55MP0006138_congestive_heart_failure1.33448204
56MP0008789_abnormal_olfactory_epithelium1.31046414
57MP0005451_abnormal_body_composition1.30425738
58MP0001765_abnormal_ion_homeostasis1.26601549
59MP0006072_abnormal_retinal_apoptosis1.23838090
60MP0006036_abnormal_mitochondrial_physio1.23685011
61MP0008775_abnormal_heart_ventricle1.23522358
62MP0002163_abnormal_gland_morphology1.20914336
63MP0001486_abnormal_startle_reflex1.20641658
64MP0002572_abnormal_emotion/affect_behav1.19213244
65MP0001544_abnormal_cardiovascular_syste1.17676088
66MP0005385_cardiovascular_system_phenoty1.17676088
67MP0008875_abnormal_xenobiotic_pharmacok1.16359319
68MP0001440_abnormal_grooming_behavior1.13330653
69MP0003787_abnormal_imprinting1.09632387
70MP0005253_abnormal_eye_physiology1.09615582
71MP0001984_abnormal_olfaction1.08536230
72MP0000003_abnormal_adipose_tissue1.08466646
73MP0002332_abnormal_exercise_endurance1.07527552
74MP0010630_abnormal_cardiac_muscle1.07262367
75MP0001502_abnormal_circadian_rhythm1.06938910
76MP0005423_abnormal_somatic_nervous1.05257236
77MP0002067_abnormal_sensory_capabilities1.02637160
78MP0008569_lethality_at_weaning1.02512831
79MP0001968_abnormal_touch/_nociception1.01892758
80MP0001501_abnormal_sleep_pattern1.01812901
81MP0002078_abnormal_glucose_homeostasis1.00310116
82MP0002653_abnormal_ependyma_morphology0.99349718
83MP0002876_abnormal_thyroid_physiology0.97714919
84MP0000631_abnormal_neuroendocrine_gland0.96189527
85MP0002229_neurodegeneration0.95904409
86MP0002693_abnormal_pancreas_physiology0.94961366
87MP0003879_abnormal_hair_cell0.94262191
88MP0002736_abnormal_nociception_after0.94137067
89MP0002161_abnormal_fertility/fecundity0.93071510
90MP0002210_abnormal_sex_determination0.92365752
91MP0002234_abnormal_pharynx_morphology0.92080070
92MP0003878_abnormal_ear_physiology0.91520553
93MP0005377_hearing/vestibular/ear_phenot0.91520553
94MP0005085_abnormal_gallbladder_physiolo0.91383653
95MP0002734_abnormal_mechanical_nocicepti0.91243033
96MP0009840_abnormal_foam_cell0.91201413
97MP0004885_abnormal_endolymph0.90747777
98MP0005332_abnormal_amino_acid0.90444343
99MP0003122_maternal_imprinting0.89903050
100MP0002127_abnormal_cardiovascular_syste0.89396045
101MP0002160_abnormal_reproductive_system0.89195595
102MP0002971_abnormal_brown_adipose0.89182569
103MP0002090_abnormal_vision0.88667253
104MP0005394_taste/olfaction_phenotype0.88417848
105MP0005499_abnormal_olfactory_system0.88417848
106MP0008877_abnormal_DNA_methylation0.88083816
107MP0002138_abnormal_hepatobiliary_system0.86856671
108MP0003121_genomic_imprinting0.86639677
109MP0008961_abnormal_basal_metabolism0.86606990
110MP0006276_abnormal_autonomic_nervous0.86335696
111MP0001986_abnormal_taste_sensitivity0.84288190
112MP0005535_abnormal_body_temperature0.84247468
113MP0010678_abnormal_skin_adnexa0.84139604
114MP0000230_abnormal_systemic_arterial0.83891699
115MP0005386_behavior/neurological_phenoty0.83034059
116MP0004924_abnormal_behavior0.83034059
117MP0004510_myositis0.82971866
118MP0010329_abnormal_lipoprotein_level0.81337519
119MP0005266_abnormal_metabolism0.81182001
120MP0000653_abnormal_sex_gland0.81094547
121MP0005646_abnormal_pituitary_gland0.80101866
122MP0003890_abnormal_embryonic-extraembry0.79400270
123MP0002139_abnormal_hepatobiliary_system0.76642693
124MP0004019_abnormal_vitamin_homeostasis0.76338119
125MP0006035_abnormal_mitochondrial_morpho0.76329313
126MP0003195_calcinosis0.75399300
127MP0002909_abnormal_adrenal_gland0.74407949
128MP0003633_abnormal_nervous_system0.73606687
129MP0009780_abnormal_chondrocyte_physiolo0.73593697
130MP0005375_adipose_tissue_phenotype0.73294897
131MP0005623_abnormal_meninges_morphology0.71235616
132MP0002108_abnormal_muscle_morphology0.69933011
133MP0002066_abnormal_motor_capabilities/c0.68220204
134MP0004185_abnormal_adipocyte_glucose0.67718325

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.89260301
2Absent/shortened dynein arms (HP:0200106)5.89260301
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.88230015
4Exercise-induced myalgia (HP:0003738)5.76330895
5Sudden death (HP:0001699)4.79479678
6Calf muscle hypertrophy (HP:0008981)4.78725732
7Muscle hypertrophy of the lower extremities (HP:0008968)4.77298875
8Exercise-induced muscle cramps (HP:0003710)4.56608979
9Abnormal respiratory motile cilium physiology (HP:0012261)4.35549326
10Myoglobinuria (HP:0002913)3.87582076
11Abnormality of the calf musculature (HP:0001430)3.86347831
12Abnormal respiratory epithelium morphology (HP:0012253)3.86336871
13Abnormal respiratory motile cilium morphology (HP:0005938)3.86336871
14Muscle fiber splitting (HP:0003555)3.74448429
15Hyporeflexia of lower limbs (HP:0002600)3.69513861
16Atrial fibrillation (HP:0005110)3.62932954
17Abnormal ciliary motility (HP:0012262)3.54207516
18Bundle branch block (HP:0011710)3.50082496
19Ventricular tachycardia (HP:0004756)3.47421322
20Hypoglycemic coma (HP:0001325)3.45442262
21Congenital stationary night blindness (HP:0007642)3.44000874
22Syncope (HP:0001279)3.40904214
23Primary atrial arrhythmia (HP:0001692)3.36442718
24Rhinitis (HP:0012384)3.27659443
25Supraventricular tachycardia (HP:0004755)3.16211616
26Infertility (HP:0000789)3.13495875
27Supraventricular arrhythmia (HP:0005115)3.05859002
28Difficulty running (HP:0009046)3.00167020
29Focal motor seizures (HP:0011153)2.98505508
30Insulin-resistant diabetes mellitus (HP:0000831)2.98376167
31Chronic bronchitis (HP:0004469)2.95004892
32Distal arthrogryposis (HP:0005684)2.88895738
33Asymmetric septal hypertrophy (HP:0001670)2.84050878
34Prolonged QT interval (HP:0001657)2.83624705
35EMG: myopathic abnormalities (HP:0003458)2.83030549
36Central scotoma (HP:0000603)2.82346251
37Muscle fiber inclusion bodies (HP:0100299)2.80643831
38Male infertility (HP:0003251)2.78669115
39Rhabdomyolysis (HP:0003201)2.77925521
40Ventricular fibrillation (HP:0001663)2.77309498
41Heart block (HP:0012722)2.74945246
42Fetal akinesia sequence (HP:0001989)2.70553677
43Late onset (HP:0003584)2.69899543
44Right ventricular cardiomyopathy (HP:0011663)2.69232616
45Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.67220416
46Hyperinsulinemic hypoglycemia (HP:0000825)2.65875616
47Hyperglycemia (HP:0003074)2.64392455
48Ventricular arrhythmia (HP:0004308)2.61663680
49Lipoatrophy (HP:0100578)2.59542919
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.58800695
51Hypoplasia of the fovea (HP:0007750)2.58800695
52Subaortic stenosis (HP:0001682)2.58294457
53Abnormality of the left ventricular outflow tract (HP:0011103)2.58294457
54Abnormal atrioventricular conduction (HP:0005150)2.55140885
55Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.52545618
56Hypoglycemic seizures (HP:0002173)2.44647395
57Left ventricular hypertrophy (HP:0001712)2.43756638
58Myopathic facies (HP:0002058)2.41186757
59Muscle stiffness (HP:0003552)2.35719793
60Dysmetric saccades (HP:0000641)2.35468205
61Popliteal pterygium (HP:0009756)2.33198231
62Myotonia (HP:0002486)2.32335173
63Type 1 muscle fiber predominance (HP:0003803)2.31690953
64Cholecystitis (HP:0001082)2.31224938
65Abnormal gallbladder physiology (HP:0012438)2.31224938
66Dilated cardiomyopathy (HP:0001644)2.29694771
67Nemaline bodies (HP:0003798)2.28721086
68Ketoacidosis (HP:0001993)2.26389118
69Atrioventricular block (HP:0001678)2.25292537
70Epileptic encephalopathy (HP:0200134)2.23146137
71Hyperventilation (HP:0002883)2.21842176
72Round ear (HP:0100830)2.21603867
73Abnormal EKG (HP:0003115)2.21582327
74Difficulty climbing stairs (HP:0003551)2.20919303
75Hyperkalemia (HP:0002153)2.20632049
76Palpitations (HP:0001962)2.19074273
77Ketosis (HP:0001946)2.18782423
78Rimmed vacuoles (HP:0003805)2.17688696
79Abnormality of the fovea (HP:0000493)2.17392611
80Anterior segment dysgenesis (HP:0007700)2.15410178
81Dyschromatopsia (HP:0007641)2.12819265
82Ulnar deviation of the wrist (HP:0003049)2.10181790
83Increased connective tissue (HP:0009025)2.09535021
84Generalized aminoaciduria (HP:0002909)2.08115717
85Abnormality of macular pigmentation (HP:0008002)2.07417156
86Abnormality of endocrine pancreas physiology (HP:0012093)2.06140425
87Abnormality of the pancreatic islet cells (HP:0006476)2.06140425
88Malignant hyperthermia (HP:0002047)2.05288277
89Hyperphosphatemia (HP:0002905)2.04493547
90Gout (HP:0001997)2.04162691
91Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99841829
92Azoospermia (HP:0000027)1.97590653
93Decreased central vision (HP:0007663)1.97068647
94Tubulointerstitial nephritis (HP:0001970)1.96726699
95Dysdiadochokinesis (HP:0002075)1.96538876
96Increased variability in muscle fiber diameter (HP:0003557)1.95103836
97Abnormality of abdominal situs (HP:0011620)1.94905986
98Abdominal situs inversus (HP:0003363)1.94905986
99Scotoma (HP:0000575)1.94539105
100Polydipsia (HP:0001959)1.93184200
101Abnormal drinking behavior (HP:0030082)1.93184200
102Bony spicule pigmentary retinopathy (HP:0007737)1.93182468
103Distal lower limb muscle weakness (HP:0009053)1.92925941
104Optic disc pallor (HP:0000543)1.92283923
105Gowers sign (HP:0003391)1.90751962
106Large for gestational age (HP:0001520)1.90286611
107Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89912352
108Nonprogressive disorder (HP:0003680)1.87555670
109Double outlet right ventricle (HP:0001719)1.86751242
110Congenital malformation of the right heart (HP:0011723)1.86751242
111Centrally nucleated skeletal muscle fibers (HP:0003687)1.86504563
112Congenital sensorineural hearing impairment (HP:0008527)1.86168973
113Hip contracture (HP:0003273)1.86059235
114Enlarged penis (HP:0000040)1.85349787
115Supernumerary spleens (HP:0009799)1.83388418
116Frequent falls (HP:0002359)1.82745543
117EMG: neuropathic changes (HP:0003445)1.82217007
118Abnormal urine output (HP:0012590)1.82118847
119Absent phalangeal crease (HP:0006109)1.82022113
120Abnormal mitochondria in muscle tissue (HP:0008316)1.81495259
121Abnormality of urine glucose concentration (HP:0011016)1.80746841
122Glycosuria (HP:0003076)1.80746841
123Generalized muscle weakness (HP:0003324)1.80220706
124Increased circulating renin level (HP:0000848)1.78322734
125Myokymia (HP:0002411)1.78308143
126Hyperuricemia (HP:0002149)1.77125390
127Increased purine levels (HP:0004368)1.77125390
128Acute encephalopathy (HP:0006846)1.76513840
129Neck muscle weakness (HP:0000467)1.75870801
130Pigmentary retinal degeneration (HP:0001146)1.75357367
131Proximal tubulopathy (HP:0000114)1.75311591
132Maternal diabetes (HP:0009800)1.75170766
133Acute necrotizing encephalopathy (HP:0006965)1.75033999
134Focal seizures (HP:0007359)1.74876287
135Abnormality of renal excretion (HP:0011036)1.74707653
136Hyperglycinuria (HP:0003108)1.74473265
137Metabolic alkalosis (HP:0200114)1.73224985
138Choroideremia (HP:0001139)1.73010318
139Gaze-evoked nystagmus (HP:0000640)1.71822186
140Hepatic necrosis (HP:0002605)1.71775420
141Truncal obesity (HP:0001956)1.71715054
142Abnormality of skeletal muscle fiber size (HP:0012084)1.71576683
143Hypophosphatemic rickets (HP:0004912)1.71370600
144Polyuria (HP:0000103)1.70596534
145Medial flaring of the eyebrow (HP:0010747)1.70016654
146Aplasia of the musculature (HP:0100854)1.68164355
147Abnormality of potassium homeostasis (HP:0011042)1.68046390

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.68704085
2PDK44.68704085
3BMPR1B4.33347673
4PRKD33.33777329
5FRK3.28813092
6PDK23.25612964
7OBSCN3.14123041
8MUSK3.09246948
9EPHA42.74794402
10PHKG12.52037687
11PHKG22.52037687
12WNK42.48247746
13PINK12.35195750
14LMTK22.27285943
15TTN2.24000615
16ICK2.09068482
17STK382.01292558
18STK391.92923466
19PTK2B1.68002977
20NTRK31.67285199
21TRPM71.59391962
22DMPK1.53293309
23MAP3K41.51830467
24PNCK1.51529168
25FGFR21.46886703
26PIK3CA1.42435346
27PLK21.38558624
28MST41.38463455
29MAP3K91.35026759
30OXSR11.32914887
31MYLK1.30354083
32CASK1.23125656
33TNIK1.22797837
34NME11.22634766
35MAP2K41.22246332
36TESK11.19049103
37STK38L1.14374747
38MAP4K21.11885851
39PAK61.10934245
40MAPK121.10474774
41BCKDK1.08592856
42MAP2K71.08375881
43RIPK41.08156405
44MAP3K71.07944659
45PASK1.07255314
46MAPK131.06444799
47TAOK31.05057010
48NEK11.02079296
49WNK10.99160881
50KSR20.96606646
51CAMK2A0.95184138
52PDK10.93861104
53PDPK10.89168395
54BMPR20.88932642
55CAMK2D0.87774784
56TAOK10.87074810
57STK30.82322968
58IRAK10.81813410
59PRKAA10.80413371
60NTRK20.80305839
61TRIM280.79941067
62FGFR30.79793078
63PRKCI0.79324745
64GRK10.78640189
65SGK2230.78363817
66SGK4940.78363817
67MAPK150.77295061
68DAPK20.77226846
69WNK30.76291025
70PRKAA20.76177970
71CAMK10.74494455
72MARK10.73245824
73ACVR1B0.72519897
74CAMK1G0.72052722
75CAMKK10.71467743
76EIF2AK30.71361271
77MAP3K60.70415112
78PRPF4B0.68776442
79SGK20.67353556
80CAMKK20.65866624
81MAP3K20.65667733
82GRK70.63630136
83PKN10.63447551
84STK110.61233604
85PRKCG0.58968447
86MOS0.58482435
87CDK90.56735447
88SGK30.56593509
89AKT20.55484890
90CAMK2G0.55186479
91ARAF0.54609554
92CDK30.54563076
93PLK40.54438018
94MAPKAPK30.54275686
95MAPK70.54120546
96KSR10.53999595
97INSRR0.53679436
98TTK0.52610167
99CCNB10.51833497
100SGK10.50995004
101PAK30.50683637
102BRAF0.50539879
103FER0.50467152
104ERBB30.50211669
105MARK20.50203374
106MINK10.48144771
107CDK50.47926017
108PRKD20.47385025
109MAP3K130.46607128
110PRKACA0.45539823
111MET0.45320374
112RAF10.45233933
113ROCK10.43387492
114CSNK1D0.43272516
115CAMK40.42532470
116GRK50.42478727
117MAP2K10.40700686
118PRKD10.40538668
119TYRO30.39978971
120MAP3K10.39835135
121MAP2K60.39675651
122STK240.37694535
123AKT30.37179834
124CSNK1G10.37149853
125PRKCE0.37050684
126CAMK2B0.36316333
127RPS6KA30.35790217
128MAP3K50.35373651
129PRKCZ0.34781727
130PRKG10.34762842
131CDC42BPA0.34428734
132AURKA0.33963596
133NEK60.33664412
134PRKACB0.33238210
135NLK0.32585151
136MAPK100.32578726
137PIK3CG0.32294186

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.43215549
2Cardiac muscle contraction_Homo sapiens_hsa042602.84033803
3Phototransduction_Homo sapiens_hsa047442.68389519
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.60534853
5Propanoate metabolism_Homo sapiens_hsa006402.55966200
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.27051386
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.02140483
8Fatty acid degradation_Homo sapiens_hsa000711.95046180
9Pyruvate metabolism_Homo sapiens_hsa006201.90781530
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90083116
11Dilated cardiomyopathy_Homo sapiens_hsa054141.77748294
12Nicotine addiction_Homo sapiens_hsa050331.77000742
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.71813517
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.67265897
15Fatty acid metabolism_Homo sapiens_hsa012121.58114517
16Circadian entrainment_Homo sapiens_hsa047131.53934945
17Oxidative phosphorylation_Homo sapiens_hsa001901.51355107
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50749225
19Carbon metabolism_Homo sapiens_hsa012001.45130489
20Butanoate metabolism_Homo sapiens_hsa006501.39784430
21Salivary secretion_Homo sapiens_hsa049701.38139022
22Glutamatergic synapse_Homo sapiens_hsa047241.36602218
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36048904
24Fatty acid biosynthesis_Homo sapiens_hsa000611.34937105
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34835940
26Amphetamine addiction_Homo sapiens_hsa050311.34660883
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34610634
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34409433
29Calcium signaling pathway_Homo sapiens_hsa040201.33369661
30Glucagon signaling pathway_Homo sapiens_hsa049221.32098027
31Basal transcription factors_Homo sapiens_hsa030221.31639374
32Olfactory transduction_Homo sapiens_hsa047401.31521907
33Renin secretion_Homo sapiens_hsa049241.31379928
34PPAR signaling pathway_Homo sapiens_hsa033201.31192578
35Oocyte meiosis_Homo sapiens_hsa041141.30793220
36Circadian rhythm_Homo sapiens_hsa047101.29422295
37Long-term potentiation_Homo sapiens_hsa047201.29089354
38Insulin secretion_Homo sapiens_hsa049111.28459483
39GABAergic synapse_Homo sapiens_hsa047271.28177737
40Gastric acid secretion_Homo sapiens_hsa049711.27271088
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26081955
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25903702
43Alzheimers disease_Homo sapiens_hsa050101.24307250
44Synaptic vesicle cycle_Homo sapiens_hsa047211.22797263
45Parkinsons disease_Homo sapiens_hsa050121.22083338
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20547459
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20117736
48Oxytocin signaling pathway_Homo sapiens_hsa049211.19061393
49Morphine addiction_Homo sapiens_hsa050321.16534613
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16526107
51Nitrogen metabolism_Homo sapiens_hsa009101.14616803
52Arginine biosynthesis_Homo sapiens_hsa002201.11704617
53Bile secretion_Homo sapiens_hsa049761.09135290
54Huntingtons disease_Homo sapiens_hsa050161.06747913
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06347535
56Caffeine metabolism_Homo sapiens_hsa002321.04933257
57Glycerolipid metabolism_Homo sapiens_hsa005611.00399666
58Regulation of autophagy_Homo sapiens_hsa041400.97089285
59Folate biosynthesis_Homo sapiens_hsa007900.96778674
60Taste transduction_Homo sapiens_hsa047420.96202860
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95762861
62cAMP signaling pathway_Homo sapiens_hsa040240.90754468
63Fructose and mannose metabolism_Homo sapiens_hsa000510.87431895
64Biosynthesis of amino acids_Homo sapiens_hsa012300.85842983
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85706367
66Histidine metabolism_Homo sapiens_hsa003400.84855632
67Collecting duct acid secretion_Homo sapiens_hsa049660.83325799
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.83001158
69Dopaminergic synapse_Homo sapiens_hsa047280.82440650
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81506218
71Sulfur metabolism_Homo sapiens_hsa009200.79512542
72Dorso-ventral axis formation_Homo sapiens_hsa043200.77865013
73Tryptophan metabolism_Homo sapiens_hsa003800.76911120
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76790444
75Cholinergic synapse_Homo sapiens_hsa047250.75226204
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74988355
77Starch and sucrose metabolism_Homo sapiens_hsa005000.74054003
78Mineral absorption_Homo sapiens_hsa049780.73493226
79Fatty acid elongation_Homo sapiens_hsa000620.72481751
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.71476875
81Peroxisome_Homo sapiens_hsa041460.71165664
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70310943
83Serotonergic synapse_Homo sapiens_hsa047260.68676142
84Pancreatic secretion_Homo sapiens_hsa049720.66792758
85Phenylalanine metabolism_Homo sapiens_hsa003600.66740206
86Linoleic acid metabolism_Homo sapiens_hsa005910.66682709
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66093836
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66052345
89GnRH signaling pathway_Homo sapiens_hsa049120.64061852
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63530382
91Inositol phosphate metabolism_Homo sapiens_hsa005620.61987134
92Tight junction_Homo sapiens_hsa045300.61223849
93Long-term depression_Homo sapiens_hsa047300.60674911
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60401188
95beta-Alanine metabolism_Homo sapiens_hsa004100.60307677
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.60035131
97Vitamin B6 metabolism_Homo sapiens_hsa007500.59912237
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.59508350
99Arginine and proline metabolism_Homo sapiens_hsa003300.59278352
100Type II diabetes mellitus_Homo sapiens_hsa049300.56913704
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55283642
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.55023959
103Cocaine addiction_Homo sapiens_hsa050300.53595408
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52005428
105Sphingolipid metabolism_Homo sapiens_hsa006000.51429696
106RNA degradation_Homo sapiens_hsa030180.50947500
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50608260
108Ovarian steroidogenesis_Homo sapiens_hsa049130.48651826
109ABC transporters_Homo sapiens_hsa020100.48588390
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48140932
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47734958
112AMPK signaling pathway_Homo sapiens_hsa041520.47497468
113Insulin signaling pathway_Homo sapiens_hsa049100.44197704
114Insulin resistance_Homo sapiens_hsa049310.41577746
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40784472
116Fat digestion and absorption_Homo sapiens_hsa049750.40753658
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40186600
118Estrogen signaling pathway_Homo sapiens_hsa049150.39252885
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38736406

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