USP22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.09207045
2presynaptic membrane organization (GO:0097090)6.38254829
3presynaptic membrane assembly (GO:0097105)5.62694338
4nucleobase catabolic process (GO:0046113)5.29182851
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.84667588
6central nervous system projection neuron axonogenesis (GO:0021952)4.83720285
7negative regulation of synaptic transmission, GABAergic (GO:0032229)4.74513214
8neuron cell-cell adhesion (GO:0007158)4.63666781
9response to pheromone (GO:0019236)4.53236167
10vocalization behavior (GO:0071625)4.38597695
11cell migration in hindbrain (GO:0021535)4.04910778
12positive regulation of synapse assembly (GO:0051965)4.03887507
13cerebral cortex radially oriented cell migration (GO:0021799)3.96147808
14neuron recognition (GO:0008038)3.93029398
15regulation of telomere maintenance via telomerase (GO:0032210)3.91900438
16regulation of NFAT protein import into nucleus (GO:0051532)3.86177897
17neurotransmitter-gated ion channel clustering (GO:0072578)3.82692145
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.75615314
19axonal fasciculation (GO:0007413)3.73557495
20synaptic vesicle docking involved in exocytosis (GO:0016081)3.72458513
21postsynaptic membrane organization (GO:0001941)3.69211804
22protein localization to synapse (GO:0035418)3.63818925
23dendrite morphogenesis (GO:0048813)3.62516062
24central nervous system neuron axonogenesis (GO:0021955)3.60456610
25axon extension (GO:0048675)3.52927880
26synaptic transmission, glutamatergic (GO:0035249)3.42664651
27auditory behavior (GO:0031223)3.41376228
28layer formation in cerebral cortex (GO:0021819)3.40401156
29regulation of synaptic vesicle exocytosis (GO:2000300)3.37761551
30limb bud formation (GO:0060174)3.36211611
31positive regulation of synapse maturation (GO:0090129)3.35380547
32regulation of synapse assembly (GO:0051963)3.35160493
33regulation of synapse maturation (GO:0090128)3.32544239
34regulation of synaptic transmission, GABAergic (GO:0032228)3.31363766
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.29279451
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28056660
37synapse assembly (GO:0007416)3.25962551
38regulation of glutamate receptor signaling pathway (GO:1900449)3.24907353
39glutamate secretion (GO:0014047)3.24590035
40dendrite development (GO:0016358)3.24053306
41regulation of telomere maintenance (GO:0032204)3.23888879
42spinal cord development (GO:0021510)3.21545336
43regulation of synaptic vesicle transport (GO:1902803)3.21497581
44dendritic spine morphogenesis (GO:0060997)3.20700553
45calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.18069063
46positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.18038341
47hippocampus development (GO:0021766)3.16532168
48synaptic vesicle maturation (GO:0016188)3.16357976
49synaptic vesicle exocytosis (GO:0016079)3.15734023
50establishment of mitochondrion localization (GO:0051654)3.15350490
51cerebellum development (GO:0021549)3.13418327
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.10816654
53mitotic sister chromatid cohesion (GO:0007064)3.07822304
54regulation of synapse organization (GO:0050807)3.07391672
55neuron projection extension (GO:1990138)3.05699308
56negative regulation of dendrite development (GO:2000171)3.04076283
57regulation of neuronal synaptic plasticity (GO:0048168)3.03449348
58regulation of synapse structural plasticity (GO:0051823)3.01857608
59mitochondrion transport along microtubule (GO:0047497)3.01757740
60establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.01757740
61startle response (GO:0001964)3.00697746
62paraxial mesoderm development (GO:0048339)3.00410487
63negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.97141838
64neuron-neuron synaptic transmission (GO:0007270)2.94475452
65response to auditory stimulus (GO:0010996)2.94375176
66establishment of nucleus localization (GO:0040023)2.93996287
67adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.93095057
68mechanosensory behavior (GO:0007638)2.92281706
69synaptic vesicle endocytosis (GO:0048488)2.91174339
70sympathetic nervous system development (GO:0048485)2.89568128
71negative regulation of axon extension involved in axon guidance (GO:0048843)2.89157747
72negative regulation of axon guidance (GO:1902668)2.87683103
73neuron migration (GO:0001764)2.85440391
74exploration behavior (GO:0035640)2.81926010
75regulation of glutamate secretion (GO:0014048)2.75414597
76cerebellar granule cell differentiation (GO:0021707)2.74688850
77glutamate receptor signaling pathway (GO:0007215)2.72156091
78negative regulation of axon extension (GO:0030517)2.71688929
79regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.70065261
80locomotory exploration behavior (GO:0035641)2.69108283
81forebrain neuron differentiation (GO:0021879)2.63629195
82negative regulation of dendrite morphogenesis (GO:0050774)2.63148368
83histone H3-K9 demethylation (GO:0033169)2.62600683
84axonogenesis (GO:0007409)2.62600016
85behavioral response to nicotine (GO:0035095)2.62337147
86regulation of dendrite morphogenesis (GO:0048814)2.60898949
87transmission of nerve impulse (GO:0019226)2.60431554
88regulation of axon extension (GO:0030516)2.59945133
89synapse organization (GO:0050808)2.59607165
90membrane assembly (GO:0071709)2.59536977
91regulation of extent of cell growth (GO:0061387)2.58416217
92glial cell proliferation (GO:0014009)2.57072155
93receptor recycling (GO:0001881)2.56400851
94facial nerve structural organization (GO:0021612)2.56206180
95dendritic spine organization (GO:0097061)2.55527398
96positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.55090098
97positive regulation of synaptic transmission, GABAergic (GO:0032230)2.54929598
98gamma-aminobutyric acid transport (GO:0015812)2.54457710
99neurotransmitter secretion (GO:0007269)2.54442201
100regulation of respiratory system process (GO:0044065)2.52682651
101regulation of axon guidance (GO:1902667)2.52182060
102homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.52087038
103positive regulation of amino acid transport (GO:0051957)2.51618297
104generation of neurons (GO:0048699)2.51396621
105negative regulation of axonogenesis (GO:0050771)2.51326689
106nervous system development (GO:0007399)2.50823513
107nucleosome disassembly (GO:0006337)2.49672464
108protein-DNA complex disassembly (GO:0032986)2.49672464
109axon extension involved in axon guidance (GO:0048846)2.45633417
110neuron projection extension involved in neuron projection guidance (GO:1902284)2.45633417
111regulation of axon extension involved in axon guidance (GO:0048841)2.45285525
112regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.43734568
113hippo signaling (GO:0035329)2.43567202
114mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.40814705
115planar cell polarity pathway involved in neural tube closure (GO:0090179)2.40487475
116nuclear pore complex assembly (GO:0051292)2.40475335
117ectodermal placode formation (GO:0060788)2.35035160
118convergent extension (GO:0060026)2.34991570
119DNA unwinding involved in DNA replication (GO:0006268)2.34378200
120cytoskeletal anchoring at plasma membrane (GO:0007016)2.29189103
121embryonic foregut morphogenesis (GO:0048617)2.29188216
122apical protein localization (GO:0045176)2.26817413
123gastrulation with mouth forming second (GO:0001702)2.23628449
124ephrin receptor signaling pathway (GO:0048013)2.22441442
125lens morphogenesis in camera-type eye (GO:0002089)2.22335495
126myotube differentiation (GO:0014902)2.21694958
127regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.19224100
128protein complex localization (GO:0031503)2.16984494
129regulation of Rac protein signal transduction (GO:0035020)2.16862157
130nuclear pore organization (GO:0006999)2.16580894
131atrial cardiac muscle cell action potential (GO:0086014)2.13297197
132negative regulation of chondrocyte differentiation (GO:0032331)2.12950203
133notochord development (GO:0030903)2.11368411
134dorsal/ventral axis specification (GO:0009950)2.10738229
135NLS-bearing protein import into nucleus (GO:0006607)2.09149841
136melanin biosynthetic process (GO:0042438)2.07283177
137regulation of cardioblast differentiation (GO:0051890)2.07269081
138regulation of sister chromatid cohesion (GO:0007063)2.04730871
139regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.03990300
140establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.02874034
141embryonic retina morphogenesis in camera-type eye (GO:0060059)2.01565099
142cell communication by electrical coupling (GO:0010644)2.01154656
143regulation of neuron migration (GO:2001222)2.01143332
144establishment or maintenance of monopolar cell polarity (GO:0061339)2.00634584
145establishment of monopolar cell polarity (GO:0061162)2.00634584
146sister chromatid segregation (GO:0000819)2.00024367
147asymmetric protein localization (GO:0008105)1.98893393
148morphogenesis of an epithelial sheet (GO:0002011)1.98139099
149suckling behavior (GO:0001967)1.97501271
150L-serine metabolic process (GO:0006563)1.96847534
151ganglion development (GO:0061548)1.96380478
152neuronal ion channel clustering (GO:0045161)1.95595292
153negative regulation of cell size (GO:0045792)1.95512615
154stress granule assembly (GO:0034063)1.95245787
155establishment or maintenance of apical/basal cell polarity (GO:0035088)1.94781270
156establishment or maintenance of bipolar cell polarity (GO:0061245)1.94781270
157negative regulation of microtubule polymerization (GO:0031115)1.94761024
158positive regulation of dendritic spine morphogenesis (GO:0061003)1.94530401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.08676044
2GBX2_23144817_ChIP-Seq_PC3_Human4.01050925
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.29751232
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.24740848
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.10116627
6E2F7_22180533_ChIP-Seq_HELA_Human2.97740009
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.57118814
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.56273970
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52115493
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34365683
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32696379
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.30253781
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.30024145
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25406597
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19796331
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19796331
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16033629
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15195647
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.14199073
20REST_21632747_ChIP-Seq_MESCs_Mouse2.12808192
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12361208
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12219728
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.10903169
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05739761
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.04337030
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02778136
27RNF2_27304074_Chip-Seq_NSC_Mouse2.02511872
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.00493051
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.95550663
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94478733
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.90845491
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.90844669
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88960867
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86772031
35* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.85935232
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.84273095
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.80525159
38TAF15_26573619_Chip-Seq_HEK293_Human1.80049175
39* P300_19829295_ChIP-Seq_ESCs_Human1.78195099
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76393891
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74667683
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72907425
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72895815
44IGF1R_20145208_ChIP-Seq_DFB_Human1.71022336
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.69348659
46* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.69282211
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68209298
48SMAD4_21799915_ChIP-Seq_A2780_Human1.65181372
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64675203
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58420866
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57563297
52AR_21909140_ChIP-Seq_LNCAP_Human1.56835030
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56648732
54DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55928637
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.55830469
56AR_21572438_ChIP-Seq_LNCaP_Human1.54872977
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.53815892
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53111991
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.52925305
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50828523
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50422850
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45898456
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45501425
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43134819
65FUS_26573619_Chip-Seq_HEK293_Human1.42661633
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40813363
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40813363
68* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40230283
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39787062
70RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39089898
71* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37517269
72DROSHA_22980978_ChIP-Seq_HELA_Human1.37400207
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36854292
74E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36069992
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35622481
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35437628
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.34615619
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.33715186
79POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.33244176
80CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.32854573
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32230305
82FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.31976537
83AR_25329375_ChIP-Seq_VCAP_Human1.29990962
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.29218566
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.29121800
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28645478
87STAT3_23295773_ChIP-Seq_U87_Human1.28533492
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.27440916
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.27413357
90FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26406727
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.24717995
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.24372909
93SOX9_26525672_Chip-Seq_HEART_Mouse1.24118206
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23915773
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22827943
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22540735
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21926871
98MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21694000
99TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19900271
100TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19389202
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19189674
102AHR_22903824_ChIP-Seq_MCF-7_Human1.17511801
103* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17135658
104STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16928217
105TCF3_18692474_ChIP-Seq_MESCs_Mouse1.15996642
106TP63_19390658_ChIP-ChIP_HaCaT_Human1.15588087
107* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15568880
108TCF4_23295773_ChIP-Seq_U87_Human1.14529330
109EWS_26573619_Chip-Seq_HEK293_Human1.13769774
110* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13456675
111ER_23166858_ChIP-Seq_MCF-7_Human1.12752317
112ZNF274_21170338_ChIP-Seq_K562_Hela1.12187508
113P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11927096
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11710007
115GATA1_26923725_Chip-Seq_HPCs_Mouse1.11535741
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11216109
117CLOCK_20551151_ChIP-Seq_293T_Human1.10838802
118AR_19668381_ChIP-Seq_PC3_Human1.10504943
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10232517
120CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09102526
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09000804
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07475466
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06385111
124ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05915030
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05562994
126MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05154308
127RUNX2_22187159_ChIP-Seq_PCA_Human1.04249515
128TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.03579852
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03089319
130NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02316431
131TP53_18474530_ChIP-ChIP_U2OS_Human1.00807390
132THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00747766
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00465630
134POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.00423702
135TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99848275
136NANOG_18555785_Chip-Seq_ESCs_Mouse0.99295982
137WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98715679
138SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98650356
139JUN_21703547_ChIP-Seq_K562_Human0.98344051
140FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98302031
141EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98272387
142NANOG_16153702_ChIP-ChIP_HESCs_Human0.98062963
143LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97806641
144ISL1_27105846_Chip-Seq_CPCs_Mouse0.97743221
145SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97548001
146SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97503713
147OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96159425
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95587390
149TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94733769
150E2F1_21310950_ChIP-Seq_MCF-7_Human0.94531162
151KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93939688
152POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90585788

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.72663723
2MP0000778_abnormal_nervous_system2.98601997
3MP0003787_abnormal_imprinting2.90804102
4MP0003880_abnormal_central_pattern2.75262350
5MP0003122_maternal_imprinting2.73868333
6MP0001188_hyperpigmentation2.68934262
7MP0003635_abnormal_synaptic_transmissio2.63906359
8MP0005171_absent_coat_pigmentation2.63776654
9MP0002735_abnormal_chemical_nociception2.61903099
10MP0002063_abnormal_learning/memory/cond2.48016987
11MP0004270_analgesia2.43240072
12MP0006292_abnormal_olfactory_placode2.37743172
13MP0000537_abnormal_urethra_morphology2.23265510
14MP0006276_abnormal_autonomic_nervous2.22388030
15MP0009745_abnormal_behavioral_response2.14143988
16MP0003121_genomic_imprinting2.12530578
17MP0002184_abnormal_innervation2.12414792
18MP0005645_abnormal_hypothalamus_physiol2.00334256
19MP0002734_abnormal_mechanical_nocicepti2.00028584
20MP0002572_abnormal_emotion/affect_behav1.99918233
21MP0000015_abnormal_ear_pigmentation1.99763213
22MP0001968_abnormal_touch/_nociception1.97494974
23MP0005423_abnormal_somatic_nervous1.88698048
24MP0002736_abnormal_nociception_after1.85868145
25MP0003283_abnormal_digestive_organ1.85608081
26MP0002064_seizures1.82508760
27MP0001529_abnormal_vocalization1.81989012
28MP0005394_taste/olfaction_phenotype1.79402612
29MP0005499_abnormal_olfactory_system1.79402612
30MP0005248_abnormal_Harderian_gland1.76519629
31MP0005623_abnormal_meninges_morphology1.75305455
32MP0002557_abnormal_social/conspecific_i1.73626116
33MP0008789_abnormal_olfactory_epithelium1.72641175
34MP0001486_abnormal_startle_reflex1.71333763
35MP0001299_abnormal_eye_distance/1.64697259
36MP0010386_abnormal_urinary_bladder1.60347530
37MP0004858_abnormal_nervous_system1.59962003
38MP0002733_abnormal_thermal_nociception1.55171065
39MP0003385_abnormal_body_wall1.55079086
40MP0000372_irregular_coat_pigmentation1.54515493
41MP0000569_abnormal_digit_pigmentation1.54314525
42MP0004811_abnormal_neuron_physiology1.53406733
43MP0005646_abnormal_pituitary_gland1.52358551
44MP0000631_abnormal_neuroendocrine_gland1.51720738
45MP0009046_muscle_twitch1.51212789
46MP0000955_abnormal_spinal_cord1.50142420
47MP0003123_paternal_imprinting1.47764431
48MP0002751_abnormal_autonomic_nervous1.47097285
49MP0004924_abnormal_behavior1.44625151
50MP0005386_behavior/neurological_phenoty1.44625151
51MP0002272_abnormal_nervous_system1.43585980
52MP0001440_abnormal_grooming_behavior1.40576898
53MP0009672_abnormal_birth_weight1.40566927
54MP0003890_abnormal_embryonic-extraembry1.40398431
55MP0005257_abnormal_intraocular_pressure1.39753750
56MP0001984_abnormal_olfaction1.39166267
57MP0004272_abnormal_basement_membrane1.37862842
58MP0002067_abnormal_sensory_capabilities1.37290585
59MP0003705_abnormal_hypodermis_morpholog1.37090779
60MP0010234_abnormal_vibrissa_follicle1.35526023
61MP0001970_abnormal_pain_threshold1.35065503
62MP0003119_abnormal_digestive_system1.32852410
63MP0003136_yellow_coat_color1.32449036
64MP0003111_abnormal_nucleus_morphology1.32054219
65MP0003861_abnormal_nervous_system1.31269425
66MP0002152_abnormal_brain_morphology1.30945538
67MP0002697_abnormal_eye_size1.28846432
68MP0002882_abnormal_neuron_morphology1.28535059
69MP0004134_abnormal_chest_morphology1.27663681
70MP0001177_atelectasis1.26643917
71MP0002638_abnormal_pupillary_reflex1.24920281
72MP0009780_abnormal_chondrocyte_physiolo1.22847312
73MP0008995_early_reproductive_senescence1.21517398
74MP0002822_catalepsy1.19902955
75MP0010094_abnormal_chromosome_stability1.19070912
76MP0002084_abnormal_developmental_patter1.17263447
77MP0002177_abnormal_outer_ear1.16993571
78MP0008569_lethality_at_weaning1.16153060
79MP0003935_abnormal_craniofacial_develop1.15430916
80MP0004885_abnormal_endolymph1.13004933
81MP0002085_abnormal_embryonic_tissue1.12460387
82MP0000751_myopathy1.11360668
83MP0001293_anophthalmia1.10149939
84MP0001502_abnormal_circadian_rhythm1.09164551
85MP0005408_hypopigmentation1.08808319
86MP0009703_decreased_birth_body1.06979298
87MP0008932_abnormal_embryonic_tissue1.03173720
88MP0002066_abnormal_motor_capabilities/c1.03168379
89MP0004742_abnormal_vestibular_system1.02678571
90MP0001346_abnormal_lacrimal_gland1.00962836
91MP0000534_abnormal_ureter_morphology0.97946583
92MP0000566_synostosis0.97531231
93MP0001849_ear_inflammation0.97467078
94MP0000049_abnormal_middle_ear0.96262613
95MP0003755_abnormal_palate_morphology0.95876194
96MP0005187_abnormal_penis_morphology0.95664759
97MP0002092_abnormal_eye_morphology0.95484544
98MP0000428_abnormal_craniofacial_morphol0.94838206
99MP0010352_gastrointestinal_tract_polyps0.94727924
100MP0005409_darkened_coat_color0.93500092
101MP0003942_abnormal_urinary_system0.93462113
102MP0002752_abnormal_somatic_nervous0.93160080
103MP0003077_abnormal_cell_cycle0.92990162
104MP0001286_abnormal_eye_development0.92579613
105MP0004133_heterotaxia0.91552359
106MP0002102_abnormal_ear_morphology0.91075632
107MP0001905_abnormal_dopamine_level0.90977693
108MP0001730_embryonic_growth_arrest0.90697836
109MP0002938_white_spotting0.90026771
110MP0004197_abnormal_fetal_growth/weight/0.88688255
111MP0000462_abnormal_digestive_system0.88687145
112MP0001672_abnormal_embryogenesis/_devel0.88284298
113MP0005380_embryogenesis_phenotype0.88284298
114MP0002233_abnormal_nose_morphology0.88264967
115MP0003938_abnormal_ear_development0.87734664
116MP0002116_abnormal_craniofacial_bone0.86959924
117MP0000026_abnormal_inner_ear0.86594736
118MP0004233_abnormal_muscle_weight0.85678353
119MP0000432_abnormal_head_morphology0.85147277
120MP0002877_abnormal_melanocyte_morpholog0.84704660
121MP0004957_abnormal_blastocyst_morpholog0.84212520
122MP0002081_perinatal_lethality0.84189002
123MP0009250_abnormal_appendicular_skeleto0.83849639
124MP0002234_abnormal_pharynx_morphology0.83465143
125MP0003115_abnormal_respiratory_system0.82727878
126MP0001963_abnormal_hearing_physiology0.81897868
127MP0010030_abnormal_orbit_morphology0.81058501
128MP0003941_abnormal_skin_development0.80814756
129MP0000538_abnormal_urinary_bladder0.80520164
130MP0002069_abnormal_eating/drinking_beha0.80443473
131MP0003693_abnormal_embryo_hatching0.80216190
132MP0000516_abnormal_urinary_system0.80095355
133MP0005367_renal/urinary_system_phenotyp0.80095355
134MP0003937_abnormal_limbs/digits/tail_de0.79947049
135MP0003567_abnormal_fetal_cardiomyocyte0.79887488
136MP0003984_embryonic_growth_retardation0.79302537
137MP0000733_abnormal_muscle_development0.79047586
138MP0002114_abnormal_axial_skeleton0.78614083
139MP0002090_abnormal_vision0.78423552
140MP0002909_abnormal_adrenal_gland0.78239550
141MP0002088_abnormal_embryonic_growth/wei0.77697523
142MP0002095_abnormal_skin_pigmentation0.76960196
143MP0005075_abnormal_melanosome_morpholog0.76441733
144MP0000681_abnormal_thyroid_gland0.75509911
145MP0008877_abnormal_DNA_methylation0.74773399
146MP0001986_abnormal_taste_sensitivity0.74174626
147MP0010770_preweaning_lethality0.73227514
148MP0002082_postnatal_lethality0.73227514
149MP0001186_pigmentation_phenotype0.71440123
150MP0001485_abnormal_pinna_reflex0.69799197

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.93761645
2Hepatoblastoma (HP:0002884)4.26259782
3Lissencephaly (HP:0001339)3.45715756
4Neoplasm of the adrenal cortex (HP:0100641)3.31248162
5Hyperventilation (HP:0002883)3.18135599
6Focal seizures (HP:0007359)3.15325755
7Papillary thyroid carcinoma (HP:0002895)3.07734437
8Aplasia/Hypoplasia of the brainstem (HP:0007362)3.04376970
9Hypoplasia of the brainstem (HP:0002365)3.04376970
10Epileptic encephalopathy (HP:0200134)3.01869652
11Absent speech (HP:0001344)2.98705962
12Limb dystonia (HP:0002451)2.98140046
13Febrile seizures (HP:0002373)2.89978713
14Abnormality of the labia minora (HP:0012880)2.85001812
15Pachygyria (HP:0001302)2.76991796
16Tented upper lip vermilion (HP:0010804)2.76276791
17Abnormal hair whorl (HP:0010721)2.74604973
18Abnormality of the corticospinal tract (HP:0002492)2.64694465
19Drooling (HP:0002307)2.60752848
20Excessive salivation (HP:0003781)2.60752848
21Myokymia (HP:0002411)2.58244230
22Inability to walk (HP:0002540)2.56693367
23Failure to thrive in infancy (HP:0001531)2.54128779
24Hyperacusis (HP:0010780)2.52696398
25Ankle clonus (HP:0011448)2.49464138
26Protruding tongue (HP:0010808)2.46755381
27Ependymoma (HP:0002888)2.46614510
28Polyphagia (HP:0002591)2.45894365
29Gait imbalance (HP:0002141)2.43317247
30Fetal akinesia sequence (HP:0001989)2.43233514
31Sleep apnea (HP:0010535)2.42478483
32High anterior hairline (HP:0009890)2.40187003
33Cortical dysplasia (HP:0002539)2.38797235
34Increased nuchal translucency (HP:0010880)2.34866372
35Atonic seizures (HP:0010819)2.32882063
36Anterior segment dysgenesis (HP:0007700)2.29764225
37Astrocytoma (HP:0009592)2.25963424
38Abnormality of the astrocytes (HP:0100707)2.25963424
39Thyroid carcinoma (HP:0002890)2.23572654
40Occipital encephalocele (HP:0002085)2.22340395
41Broad-based gait (HP:0002136)2.17130808
42Shallow orbits (HP:0000586)2.10801152
43Gastroesophageal reflux (HP:0002020)2.09571448
44Retinal dysplasia (HP:0007973)2.08960648
45Absent eyebrow (HP:0002223)2.08618516
46Spastic gait (HP:0002064)2.08058080
47Amyotrophic lateral sclerosis (HP:0007354)2.07779677
48Stomach cancer (HP:0012126)2.06920019
49Optic nerve hypoplasia (HP:0000609)2.05586890
50Dialeptic seizures (HP:0011146)2.04707516
51Akinesia (HP:0002304)2.04296527
52Hypopigmentation of the fundus (HP:0007894)2.03190390
53Specific learning disability (HP:0001328)2.03151524
54Bowel diverticulosis (HP:0005222)2.02585589
55Open mouth (HP:0000194)2.02515923
56Blue irides (HP:0000635)2.01510478
57Progressive inability to walk (HP:0002505)2.00205090
58Neoplasm of the adrenal gland (HP:0100631)1.99969717
59Trigonocephaly (HP:0000243)1.97960385
60Abnormal eating behavior (HP:0100738)1.96724030
61Insomnia (HP:0100785)1.94258170
62Aqueductal stenosis (HP:0002410)1.93936614
63Visual hallucinations (HP:0002367)1.93840908
64Abnormality of the intervertebral disk (HP:0005108)1.92699456
65Vertebral arch anomaly (HP:0008438)1.91237087
66EEG with generalized epileptiform discharges (HP:0011198)1.90353288
67Epileptiform EEG discharges (HP:0011182)1.90211719
68Progressive cerebellar ataxia (HP:0002073)1.89616051
69Hypsarrhythmia (HP:0002521)1.89134711
70Spastic diplegia (HP:0001264)1.88773328
71Arterial tortuosity (HP:0005116)1.86890401
72Turricephaly (HP:0000262)1.86336973
73Glioma (HP:0009733)1.85235825
74Elfin facies (HP:0004428)1.84396444
75Absence seizures (HP:0002121)1.83763627
76Exotropia (HP:0000577)1.83748366
77Abnormality of salivation (HP:0100755)1.83658254
78Aplasia/Hypoplasia of the sternum (HP:0006714)1.83233127
79Narrow nasal bridge (HP:0000446)1.82923285
80Impaired vibration sensation in the lower limbs (HP:0002166)1.82910373
81Pheochromocytoma (HP:0002666)1.82201835
82Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81863720
83Degeneration of the lateral corticospinal tracts (HP:0002314)1.81863720
84Nephrogenic diabetes insipidus (HP:0009806)1.81816255
85Congenital primary aphakia (HP:0007707)1.80993208
86Poor coordination (HP:0002370)1.80761845
87Amblyopia (HP:0000646)1.79567354
88Intellectual disability, moderate (HP:0002342)1.78981130
89Skull defect (HP:0001362)1.78979620
90Lower limb muscle weakness (HP:0007340)1.78414107
91Generalized hypotonia (HP:0001290)1.77385933
92Overriding aorta (HP:0002623)1.76617076
93Medial flaring of the eyebrow (HP:0010747)1.75842702
94Enlarged penis (HP:0000040)1.75012705
95Poor suck (HP:0002033)1.74743265
96Curly hair (HP:0002212)1.74190186
97Cutaneous syndactyly (HP:0012725)1.73658110
98Urinary bladder sphincter dysfunction (HP:0002839)1.73555019
99Intestinal atresia (HP:0011100)1.73445335
100Obsessive-compulsive behavior (HP:0000722)1.71794954
101Embryonal neoplasm (HP:0002898)1.71753389
102Shoulder girdle muscle weakness (HP:0003547)1.70959924
103Asymmetry of the thorax (HP:0001555)1.70918601
104Long clavicles (HP:0000890)1.70885254
105Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70217656
106Cutaneous finger syndactyly (HP:0010554)1.70067451
107Scrotal hypoplasia (HP:0000046)1.69736671
108Termporal pattern (HP:0011008)1.69306706
109Insidious onset (HP:0003587)1.69306706
110Genital tract atresia (HP:0001827)1.69185334
111Vascular tortuosity (HP:0004948)1.67807755
112Neuroendocrine neoplasm (HP:0100634)1.67265258
113Ulnar bowing (HP:0003031)1.66973406
114Labial hypoplasia (HP:0000066)1.66360738
115Megalocornea (HP:0000485)1.65770866
116Abnormality of the lower motor neuron (HP:0002366)1.65669387
117Slow-growing hair (HP:0002217)1.65420976
118Abnormality of hair growth rate (HP:0011363)1.65420976
119Renal duplication (HP:0000075)1.65369850
120Pointed chin (HP:0000307)1.64738567
121Vaginal atresia (HP:0000148)1.64709937
122Morphological abnormality of the middle ear (HP:0008609)1.64179923
123Hypothermia (HP:0002045)1.64017955
124Renal dysplasia (HP:0000110)1.64008177
125Type II lissencephaly (HP:0007260)1.63528923
126Scanning speech (HP:0002168)1.63490113
127Heterochromia iridis (HP:0001100)1.63240526
128Buphthalmos (HP:0000557)1.62535834
129Renal hypoplasia (HP:0000089)1.60899798
130Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.60802935
131Lymphangioma (HP:0100764)1.59861104
132Abnormality of chromosome segregation (HP:0002916)1.59439029
133Precocious puberty (HP:0000826)1.59065726
134Omphalocele (HP:0001539)1.58807265
135Lower limb amyotrophy (HP:0007210)1.58671309
136Megalencephaly (HP:0001355)1.56875799
137Renovascular hypertension (HP:0100817)1.51137264
138Heterotopia (HP:0002282)1.49388147
139Hypoventilation (HP:0002791)1.49005608
140Abnormality of the metopic suture (HP:0005556)1.48544496
141Thin ribs (HP:0000883)1.48101335
142Choanal stenosis (HP:0000452)1.48087314
143Sacral dimple (HP:0000960)1.47977378
144Abnormality of the ischium (HP:0003174)1.46003780
145Bifid tongue (HP:0010297)1.44052480
146Arnold-Chiari malformation (HP:0002308)1.43924786
147Shawl scrotum (HP:0000049)1.43207325
148Neonatal short-limb short stature (HP:0008921)1.43137991
149Cerebral aneurysm (HP:0004944)1.43137253
150Hammertoe (HP:0001765)1.42083114
151Abnormality of dentin (HP:0010299)1.41910978
152Volvulus (HP:0002580)1.41051744
153Abnormality of abdominal situs (HP:0011620)1.39701544
154Abdominal situs inversus (HP:0003363)1.39701544
155Premature rupture of membranes (HP:0001788)1.39052658
156Macroorchidism (HP:0000053)1.36050398
157Vitreoretinal degeneration (HP:0000655)1.35224611
158Abnormal lung lobation (HP:0002101)1.35125647
159Transitional cell carcinoma of the bladder (HP:0006740)1.34369560
160Broad thumb (HP:0011304)1.33320478
161Abnormality of the parathyroid morphology (HP:0011766)1.33305059
162Facial cleft (HP:0002006)1.32734193
163Broad long bones (HP:0005622)1.32482756
164Bladder diverticulum (HP:0000015)1.32175986
165Absent epiphyses (HP:0010577)1.31794927
166Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.31794927
167Abnormality of the aortic arch (HP:0012303)1.31676791
168Wide anterior fontanel (HP:0000260)1.30811877
169Uterine leiomyosarcoma (HP:0002891)1.29532574
170Leiomyosarcoma (HP:0100243)1.29532574
171Mild short stature (HP:0003502)1.29258554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.36068167
2CASK3.82622462
3ERBB33.46270794
4SIK33.44997752
5PRPF4B2.94406569
6MINK12.72945098
7AKT32.54300681
8MAPK132.50685801
9NTRK22.48884655
10MAP2K72.40257789
11DYRK22.31095193
12NTRK12.15522991
13BCR2.14350318
14TRIM282.13973899
15EEF2K2.09215499
16KSR11.97053773
17TSSK61.94408408
18SGK21.89194099
19MKNK21.86097360
20FGFR21.85110768
21SMG11.78344472
22MAP3K41.78105638
23NTRK31.77810827
24TAF11.76870741
25BRD41.72447693
26SGK2231.60017089
27SGK4941.60017089
28PKN21.47242126
29YES11.42814145
30ICK1.40814129
31UHMK11.38388012
32MAP3K101.38343475
33PLK21.38300720
34BUB11.30864213
35CAMK1G1.30386474
36BMPR1B1.28323903
37TYRO31.27113258
38CCNB11.23849461
39TTK1.20032216
40EPHB21.18079996
41SGK31.17283712
42MAP3K121.17211680
43PDGFRA1.17030478
44CSNK1A1L1.15918181
45CSNK1G31.14730541
46CSNK1G21.14728220
47WNK31.13794539
48LIMK11.11857842
49TNIK1.07717971
50SRPK11.07272483
51WEE11.06214703
52CDK121.05118966
53DYRK1A1.03515144
54TRIB31.01642627
55MAP3K91.00965381
56EPHA40.99278338
57RPS6KA20.98153142
58BMPR20.97355831
59LATS10.95216404
60CDK50.94939678
61STK240.93411311
62ZAK0.92289427
63PAK60.91160643
64PTK20.89625851
65CDC70.89071751
66BRSK10.87364185
67PKN10.85934314
68PNCK0.84346709
69PLK30.82819432
70SIK20.81764470
71CAMK1D0.79993394
72MAP2K40.79817623
73DAPK20.78546417
74PRKCG0.76717474
75CSNK1G10.76567361
76ALK0.76133795
77TAOK20.75770906
78PAK20.75614742
79STK38L0.72610607
80LMTK20.69395386
81PINK10.66780903
82MTOR0.66213646
83BRAF0.65528901
84CDK180.64142384
85RPS6KB10.63525975
86PLK10.63098874
87PRKD30.62725184
88ERBB40.62250553
89FER0.62057579
90LATS20.61435120
91PRKCZ0.60855994
92PAK40.60683566
93CHEK20.59959268
94PAK30.59386974
95PHKG10.58114175
96PHKG20.58114175
97ATR0.56644230
98ATM0.55423936
99PRKCE0.55085198
100PRKCH0.54735139
101PRKDC0.54159222
102NEK10.53267599
103EIF2AK30.52124829
104CAMK2A0.51294060
105VRK10.49431044
106CDK30.48989924
107CHEK10.48340157
108PLK40.48198178
109CAMK2B0.47504053
110CDK10.46168102
111CDK140.45140525
112MAPKAPK50.44699980
113CDK150.44668907
114CSNK1E0.44477667
115ADRBK20.44426640
116SGK10.44060388
117MET0.43912103
118ROCK10.43500362
119DAPK10.43442607
120IRAK20.43364514
121TTN0.43010562
122FGFR10.42104788
123MAPK100.41822653
124AKT20.41807488
125FGFR30.41765602
126PASK0.41485550
127CDK70.41354145
128EIF2AK20.41120837
129FES0.41110095
130EIF2AK10.40597861
131MAPK80.39161056
132MAP2K60.35911794
133MARK20.34798939
134CSNK1D0.34363454
135ROCK20.33626367
136CDK11A0.33485976
137CDK80.32380536
138NEK60.31689480
139AURKA0.31490273
140GRK70.31339116
141MKNK10.30276160
142CAMK40.29761167
143CAMKK10.28501117
144GSK3B0.28432200

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.22284144
2Axon guidance_Homo sapiens_hsa043602.74132583
3Synaptic vesicle cycle_Homo sapiens_hsa047212.68738627
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.36973894
5Circadian entrainment_Homo sapiens_hsa047132.26478175
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23980664
7Olfactory transduction_Homo sapiens_hsa047402.22643978
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.18848403
9GABAergic synapse_Homo sapiens_hsa047272.10286038
10Glutamatergic synapse_Homo sapiens_hsa047242.08449446
11Dopaminergic synapse_Homo sapiens_hsa047282.03872140
12Serotonergic synapse_Homo sapiens_hsa047262.02886376
13Endometrial cancer_Homo sapiens_hsa052132.01767058
14Morphine addiction_Homo sapiens_hsa050322.00843142
15Vitamin B6 metabolism_Homo sapiens_hsa007501.90451347
16Taste transduction_Homo sapiens_hsa047421.69721366
17Long-term potentiation_Homo sapiens_hsa047201.65188320
18Non-homologous end-joining_Homo sapiens_hsa034501.64888562
19Amphetamine addiction_Homo sapiens_hsa050311.63404985
20Long-term depression_Homo sapiens_hsa047301.63084661
21Cholinergic synapse_Homo sapiens_hsa047251.61152498
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60758006
23Colorectal cancer_Homo sapiens_hsa052101.59435063
24Cocaine addiction_Homo sapiens_hsa050301.59209022
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56063267
26ErbB signaling pathway_Homo sapiens_hsa040121.53201324
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.51749143
28Lysine degradation_Homo sapiens_hsa003101.51578248
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.48747272
30Basal cell carcinoma_Homo sapiens_hsa052171.47381508
31Insulin secretion_Homo sapiens_hsa049111.46999112
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36283367
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33816398
34Gap junction_Homo sapiens_hsa045401.33503480
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31082994
36Wnt signaling pathway_Homo sapiens_hsa043101.30316501
37Cell cycle_Homo sapiens_hsa041101.26507133
38Hippo signaling pathway_Homo sapiens_hsa043901.25320465
39Biosynthesis of amino acids_Homo sapiens_hsa012301.15756849
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.15651240
41Phototransduction_Homo sapiens_hsa047441.14400088
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12781253
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11331890
44Steroid biosynthesis_Homo sapiens_hsa001001.10350039
45Melanogenesis_Homo sapiens_hsa049161.09304024
46Hedgehog signaling pathway_Homo sapiens_hsa043401.03399556
47RNA transport_Homo sapiens_hsa030131.02882393
48Vibrio cholerae infection_Homo sapiens_hsa051101.01998717
49Renin secretion_Homo sapiens_hsa049241.01793353
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01698242
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00308996
52Thyroid cancer_Homo sapiens_hsa052161.00142630
53Oxytocin signaling pathway_Homo sapiens_hsa049210.99797534
54Salivary secretion_Homo sapiens_hsa049700.99616732
55Collecting duct acid secretion_Homo sapiens_hsa049660.98047035
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97160752
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.94412377
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93044781
59Glioma_Homo sapiens_hsa052140.92666268
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92619724
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92254742
62Oocyte meiosis_Homo sapiens_hsa041140.91303444
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91003623
64Selenocompound metabolism_Homo sapiens_hsa004500.90760117
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89821325
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88194616
67Ras signaling pathway_Homo sapiens_hsa040140.87189716
68GnRH signaling pathway_Homo sapiens_hsa049120.86496283
69MAPK signaling pathway_Homo sapiens_hsa040100.86268101
70Alcoholism_Homo sapiens_hsa050340.86064911
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85955499
72AMPK signaling pathway_Homo sapiens_hsa041520.84070619
73Focal adhesion_Homo sapiens_hsa045100.84068115
74Carbon metabolism_Homo sapiens_hsa012000.81320267
75cAMP signaling pathway_Homo sapiens_hsa040240.80490101
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79662675
77Proteoglycans in cancer_Homo sapiens_hsa052050.79638454
78mRNA surveillance pathway_Homo sapiens_hsa030150.78001491
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76103137
80TGF-beta signaling pathway_Homo sapiens_hsa043500.75515453
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75100108
82Calcium signaling pathway_Homo sapiens_hsa040200.75092356
83ECM-receptor interaction_Homo sapiens_hsa045120.73676272
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72773294
85Melanoma_Homo sapiens_hsa052180.72621847
86DNA replication_Homo sapiens_hsa030300.72492888
87Glucagon signaling pathway_Homo sapiens_hsa049220.72286041
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71804233
89Tight junction_Homo sapiens_hsa045300.70580302
90Estrogen signaling pathway_Homo sapiens_hsa049150.70157575
91Insulin signaling pathway_Homo sapiens_hsa049100.69447900
92Inositol phosphate metabolism_Homo sapiens_hsa005620.67846550
93Chronic myeloid leukemia_Homo sapiens_hsa052200.67088808
94mTOR signaling pathway_Homo sapiens_hsa041500.65405944
95Gastric acid secretion_Homo sapiens_hsa049710.65103977
96Mismatch repair_Homo sapiens_hsa034300.64775319
97Rap1 signaling pathway_Homo sapiens_hsa040150.64583185
98Thyroid hormone synthesis_Homo sapiens_hsa049180.63554743
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61704049
100N-Glycan biosynthesis_Homo sapiens_hsa005100.61151176
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60710158
102Pentose phosphate pathway_Homo sapiens_hsa000300.60697396
103Spliceosome_Homo sapiens_hsa030400.60554663
104Propanoate metabolism_Homo sapiens_hsa006400.59877091
105Choline metabolism in cancer_Homo sapiens_hsa052310.59577474
106Pyruvate metabolism_Homo sapiens_hsa006200.59237538
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57990161
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57506015
109Fatty acid metabolism_Homo sapiens_hsa012120.57019881
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56728152
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56333938
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.56228732
113Non-small cell lung cancer_Homo sapiens_hsa052230.56204569
114Fatty acid elongation_Homo sapiens_hsa000620.56016660
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55816024
116Fanconi anemia pathway_Homo sapiens_hsa034600.55484284
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55356776
118Regulation of autophagy_Homo sapiens_hsa041400.54705242
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54603413
120Dilated cardiomyopathy_Homo sapiens_hsa054140.53020992
121Circadian rhythm_Homo sapiens_hsa047100.50471771
122Type II diabetes mellitus_Homo sapiens_hsa049300.49898993
123Phagosome_Homo sapiens_hsa041450.48941607
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.47512783
125Adherens junction_Homo sapiens_hsa045200.47392297
126Renal cell carcinoma_Homo sapiens_hsa052110.47075505
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46782044
128Basal transcription factors_Homo sapiens_hsa030220.46087792
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45267515
130MicroRNAs in cancer_Homo sapiens_hsa052060.44319070
131Endocytosis_Homo sapiens_hsa041440.43964093
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.41181386
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41079434
134Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39923243
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39074101
136Prostate cancer_Homo sapiens_hsa052150.38036856
137Prolactin signaling pathway_Homo sapiens_hsa049170.37997853
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36814482
139Ether lipid metabolism_Homo sapiens_hsa005650.36786703
140Notch signaling pathway_Homo sapiens_hsa043300.35717271

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