USP24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K36 demethylation (GO:0070544)4.58100786
2monoubiquitinated protein deubiquitination (GO:0035520)4.39107821
3phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.37842579
4interkinetic nuclear migration (GO:0022027)4.18947583
5lysine metabolic process (GO:0006553)4.15588630
6lysine catabolic process (GO:0006554)4.15588630
7regulation of histone H3-K27 methylation (GO:0061085)4.15148992
8dicarboxylic acid biosynthetic process (GO:0043650)4.12750037
9cytoplasmic mRNA processing body assembly (GO:0033962)4.06572367
10histone H3-K9 demethylation (GO:0033169)3.87393867
11positive regulation of histone deacetylation (GO:0031065)3.80872913
12definitive hemopoiesis (GO:0060216)3.80539930
13alpha-linolenic acid metabolic process (GO:0036109)3.79031608
14negative regulation of erythrocyte differentiation (GO:0045647)3.78040790
15regulation of fatty acid beta-oxidation (GO:0031998)3.74886451
16histone lysine demethylation (GO:0070076)3.68124949
17positive regulation of fatty acid beta-oxidation (GO:0032000)3.65768377
18dosage compensation (GO:0007549)3.59380300
19histone H3-K4 trimethylation (GO:0080182)3.58634393
20carnitine shuttle (GO:0006853)3.58002157
21urea cycle (GO:0000050)3.57195669
22urea metabolic process (GO:0019627)3.57195669
23nuclear pore complex assembly (GO:0051292)3.56055296
242-oxoglutarate metabolic process (GO:0006103)3.55449437
25fatty acid transmembrane transport (GO:1902001)3.53781172
26histone demethylation (GO:0016577)3.51360304
27regulation of NFAT protein import into nucleus (GO:0051532)3.50234917
28phospholipid homeostasis (GO:0055091)3.49678288
29negative regulation of DNA repair (GO:0045738)3.49665086
30embryonic process involved in female pregnancy (GO:0060136)3.49332470
31valine metabolic process (GO:0006573)3.46085415
32peptidyl-threonine phosphorylation (GO:0018107)3.37221159
33NLS-bearing protein import into nucleus (GO:0006607)3.37084682
34regulation of cholesterol homeostasis (GO:2000188)3.34914068
35homocysteine metabolic process (GO:0050667)3.30762356
36peptidyl-threonine modification (GO:0018210)3.27118808
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.24058299
38mitotic sister chromatid cohesion (GO:0007064)3.23007119
39pre-miRNA processing (GO:0031054)3.15294474
40cysteine metabolic process (GO:0006534)3.15060766
41kynurenine metabolic process (GO:0070189)3.07743805
42peptidyl-lysine trimethylation (GO:0018023)3.07713082
43insulin-like growth factor receptor signaling pathway (GO:0048009)3.05507411
44positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.04085034
45nucleus localization (GO:0051647)3.03629755
46nitrogen cycle metabolic process (GO:0071941)3.03260860
47histone H3-K4 methylation (GO:0051568)3.03132227
48nuclear pore organization (GO:0006999)3.01959094
49negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.00840159
50cellular response to ethanol (GO:0071361)2.99045528
51negative regulation of potassium ion transmembrane transport (GO:1901380)2.98741050
52growth hormone receptor signaling pathway (GO:0060396)2.97844553
53carnitine transmembrane transport (GO:1902603)2.96858760
54carnitine transport (GO:0015879)2.96580154
55amino-acid betaine transport (GO:0015838)2.96580154
56complement activation, alternative pathway (GO:0006957)2.94763865
57mitotic chromosome condensation (GO:0007076)2.94206353
58protein demethylation (GO:0006482)2.93890903
59protein dealkylation (GO:0008214)2.93890903
60regulation of protein activation cascade (GO:2000257)2.91096470
61protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.91010860
62fatty acid homeostasis (GO:0055089)2.89575384
63positive regulation of granulocyte differentiation (GO:0030854)2.89198415
64positive T cell selection (GO:0043368)2.88332145
65positive regulation of fatty acid oxidation (GO:0046321)2.85746096
66regulation of gamma-delta T cell differentiation (GO:0045586)2.85116951
67triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.82685998
68serine family amino acid catabolic process (GO:0009071)2.81949219
69DNA duplex unwinding (GO:0032508)2.81242620
70regulation of fatty acid oxidation (GO:0046320)2.80740788
71regulation of complement activation (GO:0030449)2.80475440
72tricarboxylic acid metabolic process (GO:0072350)2.78675471
73peptidyl-lysine dimethylation (GO:0018027)2.77101458
74negative regulation of cell size (GO:0045792)2.75479292
75negative regulation of cholesterol transport (GO:0032375)2.74721569
76negative regulation of sterol transport (GO:0032372)2.74721569
77skeletal muscle adaptation (GO:0043501)2.73827636
78histone lysine methylation (GO:0034968)2.73593699
79glutamate metabolic process (GO:0006536)2.73011286
80amino-acid betaine metabolic process (GO:0006577)2.72206650
81erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.71649500
82L-phenylalanine catabolic process (GO:0006559)2.71649500
83regulation of necroptotic process (GO:0060544)2.71128625
84aspartate family amino acid catabolic process (GO:0009068)2.69760082
85regulation of RNA export from nucleus (GO:0046831)2.67638717
86mRNA stabilization (GO:0048255)2.67104455
87RNA stabilization (GO:0043489)2.67104455
88DNA unwinding involved in DNA replication (GO:0006268)2.66443182
89DNA geometric change (GO:0032392)2.66267065
90acetyl-CoA metabolic process (GO:0006084)2.65342522
91positive regulation of lipid catabolic process (GO:0050996)2.64407477
92ethanol oxidation (GO:0006069)2.64131482
93DNA synthesis involved in DNA repair (GO:0000731)2.63883481
94corticosteroid receptor signaling pathway (GO:0031958)2.63592536
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.63071381
96L-phenylalanine metabolic process (GO:0006558)2.63071381
97iron ion import (GO:0097286)2.62031542
98B cell receptor signaling pathway (GO:0050853)2.60990096
99negative regulation of fibrinolysis (GO:0051918)2.60636123
100response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.59088950
101positive thymic T cell selection (GO:0045059)2.58807236
102positive regulation of gamma-delta T cell activation (GO:0046645)2.58666355
103cellular modified amino acid catabolic process (GO:0042219)2.58560851
104embryonic retina morphogenesis in camera-type eye (GO:0060059)2.57384642
105aromatic amino acid family catabolic process (GO:0009074)2.57282514
106N-terminal protein amino acid acetylation (GO:0006474)2.56472848
107hypotonic response (GO:0006971)2.55697015
108glyoxylate metabolic process (GO:0046487)2.55555058
109regulation of histone H3-K9 methylation (GO:0051570)2.55093084
110protein carboxylation (GO:0018214)2.54270505
111peptidyl-glutamic acid carboxylation (GO:0017187)2.54270505
112histone H3-K9 modification (GO:0061647)2.53813358
113tryptophan metabolic process (GO:0006568)2.53763104
114negative regulation of histone methylation (GO:0031061)2.53484613
115sarcoplasmic reticulum calcium ion transport (GO:0070296)2.52380879
116protein export from nucleus (GO:0006611)2.52344777
117regulation of translational fidelity (GO:0006450)2.51480068
118sulfur amino acid catabolic process (GO:0000098)2.51382832
119peptidyl-serine phosphorylation (GO:0018105)2.50736167
120cellular response to growth hormone stimulus (GO:0071378)2.50110751
121regulation of cholesterol storage (GO:0010885)2.49974744
122negative regulation of lipid transport (GO:0032369)2.49687334
123myofibril assembly (GO:0030239)2.49454843
124pore complex assembly (GO:0046931)2.49083930
125negative regulation of fibroblast apoptotic process (GO:2000270)2.48684112
126positive regulation of glycogen biosynthetic process (GO:0045725)2.48565508
127indole-containing compound catabolic process (GO:0042436)2.48373756
128indolalkylamine catabolic process (GO:0046218)2.48373756
129tryptophan catabolic process (GO:0006569)2.48373756
130regulation of triglyceride catabolic process (GO:0010896)2.47947270
131regulation of gamma-delta T cell activation (GO:0046643)2.46522530
132quaternary ammonium group transport (GO:0015697)2.45763388
133peptidyl-lysine methylation (GO:0018022)2.45708428
134regulation of histone methylation (GO:0031060)2.44509823
135protein K48-linked deubiquitination (GO:0071108)2.44199531
136glycine metabolic process (GO:0006544)2.44141515
137low-density lipoprotein particle clearance (GO:0034383)2.43848604
138regulation of nucleobase-containing compound transport (GO:0032239)2.43718126
139cellular hyperosmotic response (GO:0071474)2.42795931
140protein-lipid complex assembly (GO:0065005)2.42060431
141intracellular lipid transport (GO:0032365)2.41907821
142positive regulation of DNA-templated transcription, initiation (GO:2000144)2.41600715
143negative regulation of necroptotic process (GO:0060546)2.41252355
144negative thymic T cell selection (GO:0045060)2.41040553
145positive regulation of glycolytic process (GO:0045821)2.40623407
146positive regulation of protein deacetylation (GO:0090312)2.40147963
147bile acid biosynthetic process (GO:0006699)2.39765468
148response to inactivity (GO:0014854)2.39700718
149striated muscle atrophy (GO:0014891)2.37892663
150muscle filament sliding (GO:0030049)2.37748308
151actin-myosin filament sliding (GO:0033275)2.37748308
1523-UTR-mediated mRNA stabilization (GO:0070935)2.37231151
153negative regulation of histone modification (GO:0031057)2.36298090
154sister chromatid cohesion (GO:0007062)2.35530213
155embryonic camera-type eye morphogenesis (GO:0048596)2.35452704
156phosphatidylinositol phosphorylation (GO:0046854)2.34854109
157negative T cell selection (GO:0043383)2.34594370
158germinal center formation (GO:0002467)2.34022762
159histone H4-K16 acetylation (GO:0043984)2.33362994
160histone phosphorylation (GO:0016572)2.33234567
161plasma lipoprotein particle assembly (GO:0034377)2.32974602
162regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.32863791
163antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.32586852
164megakaryocyte development (GO:0035855)2.32467190
165nucleus organization (GO:0006997)2.32342364
166positive regulation of myotube differentiation (GO:0010831)2.31819580
167biotin metabolic process (GO:0006768)2.30994017
168glucocorticoid receptor signaling pathway (GO:0042921)2.30363944
169epithelial cell differentiation involved in prostate gland development (GO:0060742)2.30217275
170regulation of protein polyubiquitination (GO:1902914)2.30131458
171positive regulation of protein import into nucleus, translocation (GO:0033160)2.30127361
172positive regulation of B cell differentiation (GO:0045579)2.29659312
173regulation of relaxation of muscle (GO:1901077)2.29377942
174negative regulation of fatty acid biosynthetic process (GO:0045717)2.29001949
175cell-substrate adherens junction assembly (GO:0007045)2.28895505
176focal adhesion assembly (GO:0048041)2.28895505
177fatty acid beta-oxidation (GO:0006635)2.28887769
178regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.28620466
179adherens junction assembly (GO:0034333)2.28403874
180regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.28285816
181response to muramyl dipeptide (GO:0032495)2.26300736
182establishment of nucleus localization (GO:0040023)2.25928287
183regulation of B cell receptor signaling pathway (GO:0050855)2.25565445

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.68151152
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.12757776
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.50067338
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.29717434
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.18920077
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.13113624
7E2F7_22180533_ChIP-Seq_HELA_Human3.01099862
8MYC_22102868_ChIP-Seq_BL_Human2.86308046
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.69931613
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55884027
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.55281794
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.47386043
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.41561256
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.25803210
15TCF7_22412390_ChIP-Seq_EML_Mouse2.18424810
16CLOCK_20551151_ChIP-Seq_293T_Human2.08477705
17* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.04091729
18GATA1_22025678_ChIP-Seq_K562_Human2.02579049
19* KDM2B_26808549_Chip-Seq_DND41_Human1.89326023
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.89078968
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.88621158
22ZNF263_19887448_ChIP-Seq_K562_Human1.86755305
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86396974
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.83114294
25* FOXA2_19822575_ChIP-Seq_HepG2_Human1.82795641
26* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81181324
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77544941
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70787525
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.70648192
30* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67422567
31* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66758990
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.66597296
33* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64143129
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.63419280
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61662170
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59510158
37DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53880348
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53302909
39VDR_21846776_ChIP-Seq_THP-1_Human1.51776552
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.48757141
41* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42344015
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41056487
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39524562
44* MAF_26560356_Chip-Seq_TH1_Human1.39473199
45* KDM2B_26808549_Chip-Seq_JURKAT_Human1.38602100
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37411115
47RUNX_20019798_ChIP-Seq_JUKART_Human1.36058945
48TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.36048310
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35979000
50UTX_26944678_Chip-Seq_JUKART_Human1.33719876
51SCL_19346495_ChIP-Seq_HPC-7_Human1.32850564
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.32413041
53TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31737014
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31564973
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.31519277
56SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31081776
57TBX20_22080862_ChIP-Seq_HEART_Mouse1.29250368
58TBX20_22328084_ChIP-Seq_HEART_Mouse1.29250368
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28807866
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.27621979
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26919204
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26650592
63* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26512578
64* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25515747
65PU_27001747_Chip-Seq_BMDM_Mouse1.24931366
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22856118
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22697178
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22562424
69IRF8_27001747_Chip-Seq_BMDM_Mouse1.22416707
70GATA1_19941826_ChIP-Seq_K562_Human1.20768637
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20605719
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20144598
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19887110
74* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19412956
75* ELK3_25401928_ChIP-Seq_HUVEC_Human1.19242576
76MYB_26560356_Chip-Seq_TH1_Human1.18511438
77STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18111830
78MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17681490
79CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17096055
80CIITA_25753668_ChIP-Seq_RAJI_Human1.15676418
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15441952
82NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14392821
83* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13798914
84PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13648417
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13200944
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.13147538
87GATA6_25053715_ChIP-Seq_YYC3_Human1.12559579
88ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11992227
89FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11762526
90FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11558128
91* CHD1_26751641_Chip-Seq_LNCaP_Human1.10776446
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09885114
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09885114
94* HNF4A_19822575_ChIP-Seq_HepG2_Human1.09394580
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09141055
96KDM2B_26808549_Chip-Seq_K562_Human1.08084217
97IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08026218
98NCOR1_26117541_ChIP-Seq_K562_Human1.07761612
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06308687
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06020525
101TP53_16413492_ChIP-PET_HCT116_Human1.05294639
102SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05272041
103ESR1_20079471_ChIP-ChIP_T-47D_Human1.05192917
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04648892
105VDR_24763502_ChIP-Seq_THP-1_Human1.04322966
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04081356
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03624164
108* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03513788
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02612511
110NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02032600
111GATA2_21666600_ChIP-Seq_HMVEC_Human1.01940936
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00955173
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00791662
114SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00570140
115ATF3_27146783_Chip-Seq_COLON_Human1.00557222
116VDR_24787735_ChIP-Seq_THP-1_Human1.00193144
117* SPI1_23127762_ChIP-Seq_K562_Human1.00025818
118GATA2_19941826_ChIP-Seq_K562_Human0.99600997
119GATA1_19941827_ChIP-Seq_MEL_Mouse0.98594424
120RUNX1_22412390_ChIP-Seq_EML_Mouse0.98550929
121* RUNX1_27514584_Chip-Seq_MCF-7_Human0.98151510
122RACK7_27058665_Chip-Seq_MCF-7_Human0.97512325
123AR_21909140_ChIP-Seq_LNCAP_Human0.97485495
124CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97178747
125* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97102246
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96862752
127* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96527456
128GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96346809
129GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95933983
130HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95872736
131ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95855469
132CREB1_26743006_Chip-Seq_LNCaP_Human0.95749373
133MYB_26560356_Chip-Seq_TH2_Human0.94548859
134GATA3_27048872_Chip-Seq_THYMUS_Human0.94002810
135* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92275075
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91759188

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.98019370
2MP0005360_urolithiasis4.22299604
3MP0002139_abnormal_hepatobiliary_system3.89060879
4MP0002009_preneoplasia3.66688124
5MP0003705_abnormal_hypodermis_morpholog3.63074921
6MP0005365_abnormal_bile_salt3.22543888
7MP0003300_gastrointestinal_ulcer3.22368780
8MP0000569_abnormal_digit_pigmentation3.13242324
9MP0003252_abnormal_bile_duct3.05072856
10MP0005451_abnormal_body_composition2.91941360
11MP0005085_abnormal_gallbladder_physiolo2.83962775
12MP0010352_gastrointestinal_tract_polyps2.64355095
13MP0004130_abnormal_muscle_cell2.35380600
14MP0010234_abnormal_vibrissa_follicle2.18678061
15MP0005076_abnormal_cell_differentiation2.18203790
16MP0010329_abnormal_lipoprotein_level2.11194567
17MP0008961_abnormal_basal_metabolism1.99417031
18MP0005409_darkened_coat_color1.96470920
19MP0005666_abnormal_adipose_tissue1.93500683
20MP0003221_abnormal_cardiomyocyte_apopto1.84784738
21MP0005670_abnormal_white_adipose1.84188922
22MP0004185_abnormal_adipocyte_glucose1.79592523
23MP0000609_abnormal_liver_physiology1.74555987
24MP0008875_abnormal_xenobiotic_pharmacok1.74310994
25MP0003566_abnormal_cell_adhesion1.74282751
26MP0003191_abnormal_cellular_cholesterol1.69498845
27MP0002166_altered_tumor_susceptibility1.64960589
28MP0001661_extended_life_span1.59215970
29MP0000749_muscle_degeneration1.56943949
30MP0000759_abnormal_skeletal_muscle1.53073158
31MP0003828_pulmonary_edema1.50551062
32MP0003045_fibrosis1.46529181
33MP0009840_abnormal_foam_cell1.45659477
34MP0010307_abnormal_tumor_latency1.45266798
35MP0003111_abnormal_nucleus_morphology1.42730673
36MP0000733_abnormal_muscle_development1.42117892
37MP0003950_abnormal_plasma_membrane1.41015760
38MP0004145_abnormal_muscle_electrophysio1.39725209
39MP0010630_abnormal_cardiac_muscle1.38518572
40MP0002396_abnormal_hematopoietic_system1.38203277
41MP0005375_adipose_tissue_phenotype1.38133449
42MP0002332_abnormal_exercise_endurance1.33922290
43MP0002106_abnormal_muscle_physiology1.33350286
44MP0004087_abnormal_muscle_fiber1.31720776
45MP0004808_abnormal_hematopoietic_stem1.28791118
46MP0000703_abnormal_thymus_morphology1.28298751
47MP0003806_abnormal_nucleotide_metabolis1.26052180
48MP0003077_abnormal_cell_cycle1.25560672
49MP0003303_peritoneal_inflammation1.25116777
50MP0005332_abnormal_amino_acid1.24865517
51MP0002118_abnormal_lipid_homeostasis1.24046245
52MP0001666_abnormal_nutrient_absorption1.20989344
53MP0008260_abnormal_autophagy1.20077448
54MP0009672_abnormal_birth_weight1.16815480
55MP0002269_muscular_atrophy1.15663607
56MP0010094_abnormal_chromosome_stability1.13801372
57MP0000350_abnormal_cell_proliferation1.13580884
58MP0005621_abnormal_cell_physiology1.12914632
59MP0003868_abnormal_feces_composition1.12814389
60MP0006138_congestive_heart_failure1.10550563
61MP0002971_abnormal_brown_adipose1.09436641
62MP0002398_abnormal_bone_marrow1.09187185
63MP0004084_abnormal_cardiac_muscle1.08889398
64MP0002138_abnormal_hepatobiliary_system1.08863933
65MP0009278_abnormal_bone_marrow1.06527693
66MP0003091_abnormal_cell_migration1.06245195
67MP0002928_abnormal_bile_duct1.05269951
68MP0005023_abnormal_wound_healing1.04537843
69MP0000598_abnormal_liver_morphology1.04134300
70MP0005369_muscle_phenotype1.03139608
71MP0005319_abnormal_enzyme/_coenzyme1.02842067
72MP0002086_abnormal_extraembryonic_tissu1.02425778
73MP0002006_tumorigenesis1.02172468
74MP0004197_abnormal_fetal_growth/weight/1.01986998
75MP0000751_myopathy1.00533219
76MP0004484_altered_response_of1.00517454
77MP0000747_muscle_weakness0.99796756
78MP0002168_other_aberrant_phenotype0.99219422
79MP0002088_abnormal_embryonic_growth/wei0.99140549
80MP0002254_reproductive_system_inflammat0.99078374
81MP0005083_abnormal_biliary_tract0.99004900
82MP0003984_embryonic_growth_retardation0.98771260
83MP0004381_abnormal_hair_follicle0.98373062
84MP0003890_abnormal_embryonic-extraembry0.96895299
85MP0009780_abnormal_chondrocyte_physiolo0.96237356
86MP0000003_abnormal_adipose_tissue0.95890031
87MP0003943_abnormal_hepatobiliary_system0.95874447
88MP0001851_eye_inflammation0.95639465
89MP0000371_diluted_coat_color0.94229160
90MP0001697_abnormal_embryo_size0.93901483
91MP0003646_muscle_fatigue0.91556911
92MP0009643_abnormal_urine_homeostasis0.91542543
93MP0001915_intracranial_hemorrhage0.91214789
94MP0009115_abnormal_fat_cell0.89027258
95MP0009703_decreased_birth_body0.87882183
96MP0005584_abnormal_enzyme/coenzyme_acti0.86772565
97MP0002877_abnormal_melanocyte_morpholog0.86019052
98MP0002722_abnormal_immune_system0.85866767
99MP0005334_abnormal_fat_pad0.83995734
100MP0001835_abnormal_antigen_presentation0.83407023
101MP0001672_abnormal_embryogenesis/_devel0.82043772
102MP0005380_embryogenesis_phenotype0.82043772
103MP0000266_abnormal_heart_morphology0.81733883
104MP0002080_prenatal_lethality0.81223020
105MP0001545_abnormal_hematopoietic_system0.81210146
106MP0005397_hematopoietic_system_phenotyp0.81210146
107MP0000689_abnormal_spleen_morphology0.81125565
108MP0005330_cardiomyopathy0.79059364
109MP0001730_embryonic_growth_arrest0.78110062
110MP0004264_abnormal_extraembryonic_tissu0.77382134
111MP0001853_heart_inflammation0.77364099
112MP0004957_abnormal_blastocyst_morpholog0.77248161
113MP0000428_abnormal_craniofacial_morphol0.77097183
114MP0002970_abnormal_white_adipose0.75867967
115MP0002136_abnormal_kidney_physiology0.75833962
116MP0005384_cellular_phenotype0.75396743
117MP0008007_abnormal_cellular_replicative0.75334707
118MP0004019_abnormal_vitamin_homeostasis0.75314410
119MP0005310_abnormal_salivary_gland0.75164907
120MP0005266_abnormal_metabolism0.74799968
121MP0010678_abnormal_skin_adnexa0.74284332
122MP0002108_abnormal_muscle_morphology0.74207613
123MP0008775_abnormal_heart_ventricle0.74087853
124MP0003656_abnormal_erythrocyte_physiolo0.73407312
125MP0004947_skin_inflammation0.73115533
126MP0003763_abnormal_thymus_physiology0.72697196
127MP0004233_abnormal_muscle_weight0.72675389
128MP0002128_abnormal_blood_circulation0.72475800
129MP0008438_abnormal_cutaneous_collagen0.71270025
130MP0008770_decreased_survivor_rate0.70379799
131MP0001849_ear_inflammation0.69563919
132MP0004036_abnormal_muscle_relaxation0.68589849
133MP0002925_abnormal_cardiovascular_devel0.68363661
134MP0003172_abnormal_lysosome_physiology0.68106556
135MP0001756_abnormal_urination0.68061335
136MP0005464_abnormal_platelet_physiology0.67060066
137MP0003279_aneurysm0.65139404
138MP0000604_amyloidosis0.63456497
139MP0009763_increased_sensitivity_to0.63069192
140MP0003453_abnormal_keratinocyte_physiol0.62434467

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)4.05616196
2Muscle fiber inclusion bodies (HP:0100299)4.03843490
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.96032892
4Subaortic stenosis (HP:0001682)3.47697533
5Abnormality of the left ventricular outflow tract (HP:0011103)3.47697533
6Deep venous thrombosis (HP:0002625)3.38683096
7Abnormality of the fingertips (HP:0001211)3.23409735
8Papillary thyroid carcinoma (HP:0002895)3.19898869
9Cerebral aneurysm (HP:0004944)2.95130816
10Macroorchidism (HP:0000053)2.94786081
11Acute myeloid leukemia (HP:0004808)2.87043147
12Complement deficiency (HP:0004431)2.83917885
13Xanthomatosis (HP:0000991)2.71205756
14Hypoalphalipoproteinemia (HP:0003233)2.70420518
15Dysmetric saccades (HP:0000641)2.68515150
16Type 1 muscle fiber predominance (HP:0003803)2.68388370
17Myocardial infarction (HP:0001658)2.67089713
18Neonatal hypoglycemia (HP:0001998)2.65381912
19Intrahepatic cholestasis (HP:0001406)2.58248601
20Centrally nucleated skeletal muscle fibers (HP:0003687)2.48638277
21Hyporeflexia of lower limbs (HP:0002600)2.46621407
22Heterotopia (HP:0002282)2.44246941
23Viral hepatitis (HP:0006562)2.44118066
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.40876024
25Abnormality of sulfur amino acid metabolism (HP:0004339)2.36865086
26Mitral valve prolapse (HP:0001634)2.34212591
27Abnormality of monocarboxylic acid metabolism (HP:0010996)2.34001458
28Subacute progressive viral hepatitis (HP:0006572)2.33798211
29Aortic aneurysm (HP:0004942)2.33710971
30Sandal gap (HP:0001852)2.33664507
31Esophageal varix (HP:0002040)2.33354385
32Aneurysm (HP:0002617)2.32692756
33Difficulty running (HP:0009046)2.32547557
34Dislocated radial head (HP:0003083)2.30758418
35Deep philtrum (HP:0002002)2.28998548
36Epidermoid cyst (HP:0200040)2.27981569
37Hypolipoproteinemia (HP:0010981)2.27003632
38Hematochezia (HP:0002573)2.25599972
39Hyperacusis (HP:0010780)2.24928891
40Urethral obstruction (HP:0000796)2.23855805
41Lymphangioma (HP:0100764)2.22567032
42Fatigue (HP:0012378)2.19487498
43Increased connective tissue (HP:0009025)2.19133300
44Spinal cord lesions (HP:0100561)2.17233917
45Syringomyelia (HP:0003396)2.17233917
46Spastic diplegia (HP:0001264)2.15903562
47Long clavicles (HP:0000890)2.15728715
48Overgrowth (HP:0001548)2.14586342
49Narrow palate (HP:0000189)2.13709364
50Ketosis (HP:0001946)2.12818558
51Elfin facies (HP:0004428)2.12040054
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.11874525
53Pseudobulbar signs (HP:0002200)2.10748811
54Distal lower limb amyotrophy (HP:0008944)2.10334386
55Hyperammonemia (HP:0001987)2.10091704
56Abnormality of skeletal muscle fiber size (HP:0012084)2.08815830
57Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.06807958
58Cystic hygroma (HP:0000476)2.06552903
59Hyperkalemia (HP:0002153)2.06215990
60Hyperlipoproteinemia (HP:0010980)2.05042302
61EMG: myopathic abnormalities (HP:0003458)2.04600863
62Hyperglycinuria (HP:0003108)2.03911126
63Ankyloglossia (HP:0010296)2.03044772
64Frequent falls (HP:0002359)2.00772523
65Hypochromic microcytic anemia (HP:0004840)2.00751254
66Hepatocellular carcinoma (HP:0001402)2.00482782
67Relative macrocephaly (HP:0004482)2.00083461
68Abnormality of the radial head (HP:0003995)1.99848065
69Abnormality of the lower motor neuron (HP:0002366)1.98426936
70Hypoglycemic coma (HP:0001325)1.97209556
71Hypobetalipoproteinemia (HP:0003563)1.97108286
72Distal arthrogryposis (HP:0005684)1.96860259
73Rectal prolapse (HP:0002035)1.96146519
74T lymphocytopenia (HP:0005403)1.96037984
75Enlarged penis (HP:0000040)1.95637841
76Long eyelashes (HP:0000527)1.94978074
77Germ cell neoplasia (HP:0100728)1.94166919
78Abnormality of the calcaneus (HP:0008364)1.93711560
79Abnormality of complement system (HP:0005339)1.93475009
80Ulnar deviation of the wrist (HP:0003049)1.92722079
81Muscle hypertrophy of the lower extremities (HP:0008968)1.92532827
82Increased variability in muscle fiber diameter (HP:0003557)1.92369787
83Increased density of long bones (HP:0006392)1.91897340
84Vertebral arch anomaly (HP:0008438)1.91157180
85Renovascular hypertension (HP:0100817)1.90960810
86Back pain (HP:0003418)1.90036658
87Insidious onset (HP:0003587)1.89129484
88Termporal pattern (HP:0011008)1.89129484
89Calf muscle hypertrophy (HP:0008981)1.88968067
90Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.87597198
91Cubitus valgus (HP:0002967)1.86002737
92Exercise-induced myalgia (HP:0003738)1.85741498
93Asymmetry of the thorax (HP:0001555)1.85439595
94Exercise-induced muscle cramps (HP:0003710)1.85353687
95Myoglobinuria (HP:0002913)1.84082675
96Mitral stenosis (HP:0001718)1.84028296
97Osteolytic defects of the phalanges of the hand (HP:0009771)1.83961576
98Osteolytic defects of the hand bones (HP:0009699)1.83961576
99Abnormality of serine family amino acid metabolism (HP:0010894)1.83813565
100Abnormality of glycine metabolism (HP:0010895)1.83813565
101Submucous cleft hard palate (HP:0000176)1.83172492
102Slow saccadic eye movements (HP:0000514)1.82563993
103Acanthocytosis (HP:0001927)1.81806877
104Abnormality of the common coagulation pathway (HP:0010990)1.81296126
105Resting tremor (HP:0002322)1.81122623
106Low anterior hairline (HP:0000294)1.78822150
107Flat acetabular roof (HP:0003180)1.78653861
108Shallow orbits (HP:0000586)1.78323394
109EMG: neuropathic changes (HP:0003445)1.77820477
110Rimmed vacuoles (HP:0003805)1.76545186
111Ketoacidosis (HP:0001993)1.76110513
112Astrocytoma (HP:0009592)1.75435357
113Abnormality of the astrocytes (HP:0100707)1.75435357
114Myopathic facies (HP:0002058)1.75415182
115Upper limb amyotrophy (HP:0009129)1.74036890
116Distal upper limb amyotrophy (HP:0007149)1.74036890
117Thyroid carcinoma (HP:0002890)1.73558816
118Truncal obesity (HP:0001956)1.73183605
119Hypercholesterolemia (HP:0003124)1.73165777
120Obsessive-compulsive behavior (HP:0000722)1.72287011
121Colitis (HP:0002583)1.72199305
122Short chin (HP:0000331)1.72064831
123Curly hair (HP:0002212)1.71918610
124Malignant gastrointestinal tract tumors (HP:0006749)1.71512249
125Gastrointestinal carcinoma (HP:0002672)1.71512249
126Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70672560
127Short 4th metacarpal (HP:0010044)1.70672560
128Transitional cell carcinoma of the bladder (HP:0006740)1.70038181
129Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69867906
130Abnormality of purine metabolism (HP:0004352)1.69661731
131Right ventricular cardiomyopathy (HP:0011663)1.69218953
132Abnormal foot bone ossification (HP:0010675)1.69185110
133Uterine leiomyosarcoma (HP:0002891)1.69173280
134Leiomyosarcoma (HP:0100243)1.69173280
135Abnormality of the Achilles tendon (HP:0005109)1.68994879
136Volvulus (HP:0002580)1.68103239
137Abnormality of chromosome segregation (HP:0002916)1.66997505
138Disproportionate tall stature (HP:0001519)1.66960409
139Ependymoma (HP:0002888)1.66016273
140Abnormality of aspartate family amino acid metabolism (HP:0010899)1.65836030
141Abnormality of T cell number (HP:0011839)1.65619506
142Hypoplastic ischia (HP:0003175)1.64644838
143Skin nodule (HP:0200036)1.64401771
144Nephroblastoma (Wilms tumor) (HP:0002667)1.63855415
145Bladder carcinoma (HP:0002862)1.63605437
146Bladder neoplasm (HP:0009725)1.63605437
147Coarse hair (HP:0002208)1.62299115
148Hand muscle atrophy (HP:0009130)1.62164739
149Autoimmune thrombocytopenia (HP:0001973)1.62144907
150Hyperglycinemia (HP:0002154)1.61696570
151Abnormality of oral frenula (HP:0000190)1.61422290
152Muscle fiber splitting (HP:0003555)1.61290717
153Abnormality of the 4th metacarpal (HP:0010012)1.60948354
154Global brain atrophy (HP:0002283)1.60853781
155Broad palm (HP:0001169)1.60834488
156Broad metatarsal (HP:0001783)1.60630493
157Fibrous tissue neoplasm (HP:0012316)1.60336840
158Upper motor neuron abnormality (HP:0002127)1.60160005
159Fair hair (HP:0002286)1.59411758
160Eczematoid dermatitis (HP:0000976)1.59365925
161Large earlobe (HP:0009748)1.59335211
162Cortical dysplasia (HP:0002539)1.58680911
163Polycythemia (HP:0001901)1.58668972
164Deep palmar crease (HP:0006191)1.58091244
165Progressive external ophthalmoplegia (HP:0000590)1.57811920
166Fibroma (HP:0010614)1.57241490
167Cafe-au-lait spot (HP:0000957)1.56342236
168Lower limb amyotrophy (HP:0007210)1.56284023
169Prominent nose (HP:0000448)1.56026934
170Increased CSF protein (HP:0002922)1.55703246
171Recurrent viral infections (HP:0004429)1.55328651
172Poikilocytosis (HP:0004447)1.55026563
173Sparse lateral eyebrow (HP:0005338)1.54352017
174Hamartoma of the eye (HP:0010568)1.53950896
175Hepatitis (HP:0012115)1.53892663
176Ulnar bowing (HP:0003031)1.53850145
177Gout (HP:0001997)1.53759779
178Increased mean platelet volume (HP:0011877)1.53561596
179Areflexia of lower limbs (HP:0002522)1.53128131

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.52646238
2PKN23.49679579
3CDK123.42276501
4EEF2K2.95674649
5CAMK1D2.85123845
6SIK12.69019397
7PRPF4B2.61057211
8TTN2.58295294
9CAMK1G2.55435142
10LATS12.50559196
11MAP3K102.25444459
12RIPK11.86475121
13AKT31.82080086
14FGFR41.78834677
15PTK61.74503880
16FGFR31.69966426
17MAP3K71.65182443
18PIK3CG1.64266025
19PDGFRA1.55477190
20NLK1.50302849
21MAP3K141.48198971
22ERN11.48110912
23MAP4K11.47766812
24MTOR1.43988125
25TRPM71.40908501
26CDK61.38421874
27SGK31.37572010
28JAK11.36147686
29TGFBR21.35328905
30SCYL21.32680848
31MAP3K61.30433610
32DMPK1.27183792
33LMTK21.24096980
34KSR21.20767001
35FGFR21.20353044
36STK101.15729292
37STK31.14667788
38TAOK11.12291720
39BRD41.09195028
40TYK21.09182140
41SMG11.05235486
42CDK41.04610339
43ALK1.04514231
44FRK1.03498397
45PDGFRB1.02456632
46SIK21.01918559
47PDK41.01556130
48PDK31.01556130
49ICK1.01474750
50NEK10.99378336
51NEK20.98262407
52RET0.95060809
53YES10.94537296
54KSR10.92138756
55JAK30.88499409
56LRRK20.88014233
57SGK2230.87497900
58SGK4940.87497900
59BMX0.86427375
60STK380.85820590
61BTK0.84724162
62JAK20.84611625
63MAP2K30.82883514
64CLK10.82123655
65PRKAA20.81127337
66RIPK40.80530047
67PRKCH0.80081868
68CDC70.79774120
69ZAP700.78504945
70FGFR10.78463762
71CSF1R0.77618025
72PRKAA10.77234779
73INSRR0.74810532
74MAPK110.74774748
75CAMKK20.74772124
76RAF10.71782915
77RPS6KB10.70741724
78EPHB10.70272107
79MAP3K10.70064989
80SGK20.69358710
81BLK0.69087692
82MKNK20.69029835
83BMPR20.68796979
84NEK60.67570052
85ITK0.66149133
86CHEK10.65873015
87CDK90.63769410
88TEC0.63646631
89PIM10.63600824
90PDK10.63261309
91PAK20.63127968
92WNK10.62407274
93BRSK20.62288864
94TYRO30.62239833
95GRK60.62193415
96TAOK30.59590968
97MAPK100.58605176
98RPS6KB20.57730543
99FLT30.57268994
100HIPK20.55439852
101HCK0.54243032
102PHKG20.54020866
103PHKG10.54020866
104STK40.51905969
105CAMK40.51608250
106MKNK10.51528194
107NEK90.51116003
108CAMKK10.49913505
109CSNK1D0.49851643
110STK110.48317406
111ERBB20.47617685
112MAP3K80.47152676
113OBSCN0.46946786
114PRKD30.45582370
115PASK0.45049606
116MELK0.44914149
117MAP3K30.44405187
118CHUK0.43166302
119PRKD10.42893346
120IRAK10.42861180
121CDC42BPA0.42619099
122CSK0.41029655
123SGK10.40835185
124IKBKE0.40611430
125PDPK10.40510785
126LCK0.40061815
127SYK0.39949482
128BCKDK0.39827338
129MAP2K40.39012166
130PTK20.38935580
131MAPK120.38807142
132ATM0.38657132
133MARK30.38073276
134MARK20.38009215
135MAP3K20.37655095
136MAP3K130.37203822
137GSK3A0.37133420
138FES0.36980911
139* CDK20.36012953
140EPHA30.35047494

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.05647398
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96053288
3Lysine degradation_Homo sapiens_hsa003102.42927071
4Arginine biosynthesis_Homo sapiens_hsa002202.41237746
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.32427085
6Fatty acid degradation_Homo sapiens_hsa000712.16181813
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.99807509
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.93155744
9Propanoate metabolism_Homo sapiens_hsa006401.73596789
10PPAR signaling pathway_Homo sapiens_hsa033201.69810852
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66075906
12Fatty acid metabolism_Homo sapiens_hsa012121.61003049
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60844990
14Renal cell carcinoma_Homo sapiens_hsa052111.59348899
15Complement and coagulation cascades_Homo sapiens_hsa046101.56781569
16Thyroid cancer_Homo sapiens_hsa052161.55373062
17Bile secretion_Homo sapiens_hsa049761.52822174
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52485757
19Tryptophan metabolism_Homo sapiens_hsa003801.50852008
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47291101
21Insulin resistance_Homo sapiens_hsa049311.45837596
22Fatty acid biosynthesis_Homo sapiens_hsa000611.43149807
23ErbB signaling pathway_Homo sapiens_hsa040121.35280938
24VEGF signaling pathway_Homo sapiens_hsa043701.32679381
25Circadian rhythm_Homo sapiens_hsa047101.29859208
26Selenocompound metabolism_Homo sapiens_hsa004501.26992641
27Caffeine metabolism_Homo sapiens_hsa002321.25894414
28mTOR signaling pathway_Homo sapiens_hsa041501.24395229
29Hepatitis B_Homo sapiens_hsa051611.24113392
30ABC transporters_Homo sapiens_hsa020101.22326774
31Choline metabolism in cancer_Homo sapiens_hsa052311.20511581
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.16626026
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16139354
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15668046
35Carbon metabolism_Homo sapiens_hsa012001.14184065
36Measles_Homo sapiens_hsa051621.12196831
37Butanoate metabolism_Homo sapiens_hsa006501.11694459
38Staphylococcus aureus infection_Homo sapiens_hsa051501.11279280
39Chronic myeloid leukemia_Homo sapiens_hsa052201.09837070
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07953584
41Long-term potentiation_Homo sapiens_hsa047201.06541852
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.05564632
43Biosynthesis of amino acids_Homo sapiens_hsa012301.02107710
44AMPK signaling pathway_Homo sapiens_hsa041521.01260079
45GnRH signaling pathway_Homo sapiens_hsa049120.97319350
46Starch and sucrose metabolism_Homo sapiens_hsa005000.96410236
47mRNA surveillance pathway_Homo sapiens_hsa030150.95819353
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95598604
49Glucagon signaling pathway_Homo sapiens_hsa049220.94479741
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94301636
51B cell receptor signaling pathway_Homo sapiens_hsa046620.94215077
52Hepatitis C_Homo sapiens_hsa051600.93797465
53Insulin signaling pathway_Homo sapiens_hsa049100.93559620
54Type II diabetes mellitus_Homo sapiens_hsa049300.92837046
55Cell cycle_Homo sapiens_hsa041100.92523746
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.92380831
57Influenza A_Homo sapiens_hsa051640.90324008
58One carbon pool by folate_Homo sapiens_hsa006700.90200234
59Pyruvate metabolism_Homo sapiens_hsa006200.89379067
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.89094919
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88790444
62TNF signaling pathway_Homo sapiens_hsa046680.88518656
63Dorso-ventral axis formation_Homo sapiens_hsa043200.88318537
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88013321
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87841541
66Adherens junction_Homo sapiens_hsa045200.87801421
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86794922
68Non-homologous end-joining_Homo sapiens_hsa034500.86731008
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86703159
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.84915815
71beta-Alanine metabolism_Homo sapiens_hsa004100.84399428
72Small cell lung cancer_Homo sapiens_hsa052220.82371937
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81824672
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80609655
75Non-small cell lung cancer_Homo sapiens_hsa052230.80567078
76Leishmaniasis_Homo sapiens_hsa051400.79485204
77Glycerolipid metabolism_Homo sapiens_hsa005610.78823680
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77983369
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77862425
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76912079
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75921204
82Proteoglycans in cancer_Homo sapiens_hsa052050.74768371
83Focal adhesion_Homo sapiens_hsa045100.73831729
84Apoptosis_Homo sapiens_hsa042100.72354487
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71119644
86Herpes simplex infection_Homo sapiens_hsa051680.70484853
87MicroRNAs in cancer_Homo sapiens_hsa052060.70425493
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.70197554
89Pancreatic cancer_Homo sapiens_hsa052120.69343009
90Viral myocarditis_Homo sapiens_hsa054160.69284293
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68947255
92Peroxisome_Homo sapiens_hsa041460.68148834
93Endometrial cancer_Homo sapiens_hsa052130.67705171
94Glioma_Homo sapiens_hsa052140.66890677
95Acute myeloid leukemia_Homo sapiens_hsa052210.66830410
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.66120879
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65913130
98MAPK signaling pathway_Homo sapiens_hsa040100.63895573
99Bladder cancer_Homo sapiens_hsa052190.63264687
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.62820681
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62508821
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60952633
103Osteoclast differentiation_Homo sapiens_hsa043800.59804134
104Dilated cardiomyopathy_Homo sapiens_hsa054140.59747964
105FoxO signaling pathway_Homo sapiens_hsa040680.57607782
106Other glycan degradation_Homo sapiens_hsa005110.56425562
107Melanoma_Homo sapiens_hsa052180.55825493
108Pathways in cancer_Homo sapiens_hsa052000.53794644
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53495159
110Toxoplasmosis_Homo sapiens_hsa051450.52703045
111Oxytocin signaling pathway_Homo sapiens_hsa049210.52244730
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51846045
113Fat digestion and absorption_Homo sapiens_hsa049750.51597816
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51058194
115Systemic lupus erythematosus_Homo sapiens_hsa053220.50494873
116Chemokine signaling pathway_Homo sapiens_hsa040620.50389054
117Tuberculosis_Homo sapiens_hsa051520.50108790
118Platelet activation_Homo sapiens_hsa046110.49683554
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49252450
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49225032
121Long-term depression_Homo sapiens_hsa047300.48968897
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.48130337
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48104978
124T cell receptor signaling pathway_Homo sapiens_hsa046600.46894847
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46700621
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46594612
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46506415
128Amoebiasis_Homo sapiens_hsa051460.45305495
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.42659373
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.42378766
131Prostate cancer_Homo sapiens_hsa052150.42289068
132Pentose phosphate pathway_Homo sapiens_hsa000300.40392315
133Inositol phosphate metabolism_Homo sapiens_hsa005620.40092736
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38683839
135HIF-1 signaling pathway_Homo sapiens_hsa040660.38660630
136Prolactin signaling pathway_Homo sapiens_hsa049170.37846393
137Estrogen signaling pathway_Homo sapiens_hsa049150.36975271
138ECM-receptor interaction_Homo sapiens_hsa045120.36280671
139HTLV-I infection_Homo sapiens_hsa051660.35944983
140Colorectal cancer_Homo sapiens_hsa052100.35826418
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34449189
142Primary immunodeficiency_Homo sapiens_hsa053400.33358918
143Notch signaling pathway_Homo sapiens_hsa043300.32732234
144Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32177817
145Viral carcinogenesis_Homo sapiens_hsa052030.31654504

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