USP25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.20852183
2establishment of protein localization to Golgi (GO:0072600)5.09453990
3protein targeting to Golgi (GO:0000042)5.08741287
4retrograde transport, vesicle recycling within Golgi (GO:0000301)4.89349831
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.78660350
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.78660350
7positive regulation of gamma-delta T cell activation (GO:0046645)4.77077882
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.61730888
9antigen processing and presentation of endogenous antigen (GO:0019883)4.38350828
10nuclear pore organization (GO:0006999)4.17555622
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.95798662
12positive regulation by organism of defense response of other organism involved in symbiotic interact3.95798662
13modulation by symbiont of host immune response (GO:0052553)3.95798662
14positive regulation by symbiont of host defense response (GO:0052509)3.95798662
15modulation by symbiont of host defense response (GO:0052031)3.95798662
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.95798662
17neutrophil activation involved in immune response (GO:0002283)3.84053584
18phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.79853943
19response to type I interferon (GO:0034340)3.76646118
20monoubiquitinated protein deubiquitination (GO:0035520)3.76501871
21leukocyte aggregation (GO:0070486)3.75897846
22cellular response to type I interferon (GO:0071357)3.68333208
23type I interferon signaling pathway (GO:0060337)3.68333208
24muscle filament sliding (GO:0030049)3.66758381
25actin-myosin filament sliding (GO:0033275)3.66758381
26pore complex assembly (GO:0046931)3.64712737
27histone H3-K36 demethylation (GO:0070544)3.62971513
28interkinetic nuclear migration (GO:0022027)3.62635276
29response to peptidoglycan (GO:0032494)3.58558822
30positive regulation of interferon-alpha production (GO:0032727)3.53361836
31regulation of gamma-delta T cell activation (GO:0046643)3.51090719
32regulation of gamma-delta T cell differentiation (GO:0045586)3.49965934
33T cell migration (GO:0072678)3.44507644
34regulation of interferon-alpha production (GO:0032647)3.42836746
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.42541548
36histone H3-K9 demethylation (GO:0033169)3.42169115
37positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.41463969
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.33211180
39negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.30033826
40response to muramyl dipeptide (GO:0032495)3.27051469
41cellular response to ethanol (GO:0071361)3.26117646
42neutrophil activation (GO:0042119)3.25961630
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.25476902
44actin-mediated cell contraction (GO:0070252)3.25370284
45regulation of B cell receptor signaling pathway (GO:0050855)3.24283302
46interferon-gamma production (GO:0032609)3.22980719
47granulocyte activation (GO:0036230)3.20208750
48Golgi to endosome transport (GO:0006895)3.19430798
49sarcoplasmic reticulum calcium ion transport (GO:0070296)3.17383713
50regulation of relaxation of muscle (GO:1901077)3.16564372
51skeletal muscle adaptation (GO:0043501)3.16010305
52regulation of interferon-beta biosynthetic process (GO:0045357)3.15465645
53regulation of T-helper 1 cell differentiation (GO:0045625)3.14739964
54respiratory burst (GO:0045730)3.14502617
55negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.09498631
56negative regulation of cell killing (GO:0031342)3.09498631
57myofibril assembly (GO:0030239)3.06298413
58protein localization to Golgi apparatus (GO:0034067)3.04777797
59cellular extravasation (GO:0045123)3.04613216
60negative regulation of inclusion body assembly (GO:0090084)3.03750447
61actin filament-based movement (GO:0030048)3.00052962
62detection of molecule of bacterial origin (GO:0032490)2.99445529
63regulation of alpha-beta T cell proliferation (GO:0046640)2.98997150
64histone mRNA catabolic process (GO:0071044)2.97545696
65T-helper 1 type immune response (GO:0042088)2.97524750
66mature B cell differentiation (GO:0002335)2.96549067
67regulation of necroptotic process (GO:0060544)2.93497354
68positive regulation of natural killer cell differentiation (GO:0032825)2.92635851
69JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.92331552
70regulation of interleukin-12 biosynthetic process (GO:0045075)2.92317478
71skeletal muscle contraction (GO:0003009)2.91879591
72immunoglobulin mediated immune response (GO:0016064)2.91673129
73interferon-gamma-mediated signaling pathway (GO:0060333)2.91211187
74positive regulation of antigen processing and presentation (GO:0002579)2.89981912
75negative T cell selection (GO:0043383)2.89511111
76definitive hemopoiesis (GO:0060216)2.85096622
77positive thymic T cell selection (GO:0045059)2.84875589
78positive regulation of B cell differentiation (GO:0045579)2.83608779
79negative regulation of potassium ion transmembrane transport (GO:1901380)2.83413542
80negative thymic T cell selection (GO:0045060)2.81125606
81tolerance induction (GO:0002507)2.75670782
82response to interferon-alpha (GO:0035455)2.74867798
83lipopolysaccharide-mediated signaling pathway (GO:0031663)2.74021211
84response to interleukin-15 (GO:0070672)2.73455097
85early endosome to late endosome transport (GO:0045022)2.72487822
86positive regulation of toll-like receptor signaling pathway (GO:0034123)2.72438631
87myeloid cell activation involved in immune response (GO:0002275)2.71590818
88macrophage activation involved in immune response (GO:0002281)2.71550916
89positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.71287295
90positive regulation of T cell cytokine production (GO:0002726)2.70988163
91growth hormone receptor signaling pathway (GO:0060396)2.70652207
92response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.69961961
93response to host immune response (GO:0052572)2.69961961
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.67324513
95positive regulation of interleukin-2 production (GO:0032743)2.66749812
96histone lysine demethylation (GO:0070076)2.65956083
97regulation of T cell tolerance induction (GO:0002664)2.65493324
98positive regulation of alpha-beta T cell proliferation (GO:0046641)2.65386656
99defense response to protozoan (GO:0042832)2.65328310
100cellular response to zinc ion (GO:0071294)2.65070234
101response to protozoan (GO:0001562)2.64878726
102B cell receptor signaling pathway (GO:0050853)2.63844211
103regulation of histone H3-K27 methylation (GO:0061085)2.63130457
104striated muscle atrophy (GO:0014891)2.62935330
105nucleus organization (GO:0006997)2.62738459
106hepatocyte apoptotic process (GO:0097284)2.62676425
107positive regulation of interleukin-17 production (GO:0032740)2.61426823
108regulation of B cell differentiation (GO:0045577)2.60602887
109leukocyte cell-cell adhesion (GO:0007159)2.60377607
110glomerular visceral epithelial cell development (GO:0072015)2.59238920
111cellular response to interleukin-15 (GO:0071350)2.58721647
112cellular response to virus (GO:0098586)2.58549412
113insulin-like growth factor receptor signaling pathway (GO:0048009)2.56308996
114regulation of type I interferon-mediated signaling pathway (GO:0060338)2.56077258
115Arp2/3 complex-mediated actin nucleation (GO:0034314)2.55754941
116regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.55544480
117pinocytosis (GO:0006907)2.54789091
118regulation of centriole replication (GO:0046599)2.54681533
119dendritic cell chemotaxis (GO:0002407)2.54280985
120positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.53323385
121cellular response to exogenous dsRNA (GO:0071360)2.53318166
122negative regulation of DNA repair (GO:0045738)2.53302259
123regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.53282003
124production of molecular mediator involved in inflammatory response (GO:0002532)2.53078729
125myeloid dendritic cell activation (GO:0001773)2.52817273
126regulation of hypersensitivity (GO:0002883)2.52425064
127negative regulation of viral genome replication (GO:0045071)2.52243028
128embryonic process involved in female pregnancy (GO:0060136)2.51866310
129response to host (GO:0075136)2.51195918
130response to host defenses (GO:0052200)2.51195918
131response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.51195918
132histone demethylation (GO:0016577)2.50656255
133DNA packaging (GO:0006323)2.50464546
134NIK/NF-kappaB signaling (GO:0038061)2.48776309
135positive regulation of T-helper cell differentiation (GO:0045624)2.48343862
136regulation of skeletal muscle contraction (GO:0014819)2.48074675
137thymic T cell selection (GO:0045061)2.47173122
138regulation of protein polyubiquitination (GO:1902914)2.47113593
139macrophage activation (GO:0042116)2.47082148
140regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.46782893
141negative regulation of T-helper cell differentiation (GO:0045623)2.46742534
142negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.46742534
143hypotonic response (GO:0006971)2.46478068
144natural killer cell mediated cytotoxicity (GO:0042267)2.46148204
145natural killer cell mediated immunity (GO:0002228)2.46148204
146positive regulation of defense response to virus by host (GO:0002230)2.45623841
147T cell selection (GO:0045058)2.45479983
148negative regulation of necroptotic process (GO:0060546)2.45236467
149microglial cell activation (GO:0001774)2.45233662
150positive regulation of type 2 immune response (GO:0002830)2.45144779
151regulation of T-helper 2 cell differentiation (GO:0045628)2.45112758
152positive regulation of myotube differentiation (GO:0010831)2.43934009
153detection of other organism (GO:0098543)2.42680466
154NLS-bearing protein import into nucleus (GO:0006607)2.41629476
155cellular response to epinephrine stimulus (GO:0071872)2.40798658
156chromosome condensation (GO:0030261)2.39794012
157regulation of establishment of cell polarity (GO:2000114)2.39474335
158sperm motility (GO:0030317)2.39304964
159fusion of sperm to egg plasma membrane (GO:0007342)2.38717979
160positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.38319892
161cellular response to growth hormone stimulus (GO:0071378)2.38142193
162negative regulation of NF-kappaB import into nucleus (GO:0042347)2.35278939
163iron ion import (GO:0097286)2.35274155
164sarcomere organization (GO:0045214)2.35268518
165skeletal muscle tissue regeneration (GO:0043403)2.35157956
166detection of external biotic stimulus (GO:0098581)2.33515528
167cardiac muscle hypertrophy (GO:0003300)2.33121952
168response to epinephrine (GO:0071871)2.31689738
169positive T cell selection (GO:0043368)2.31118672
170negative regulation of T cell mediated immunity (GO:0002710)2.30317981
171regulation of Rab GTPase activity (GO:0032313)2.30302975
172positive regulation of Rab GTPase activity (GO:0032851)2.30302975
173cytoplasmic mRNA processing body assembly (GO:0033962)2.30169023
174nucleus localization (GO:0051647)2.30106275
175regulation of RNA export from nucleus (GO:0046831)2.30030014
176regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.29733982
177acrosome reaction (GO:0007340)2.29288142
178muscle atrophy (GO:0014889)2.28599905
179striated muscle adaptation (GO:0014888)2.27409723
180negative regulation of erythrocyte differentiation (GO:0045647)2.26882873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.61873624
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.28456643
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.65609065
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.34620310
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.99547513
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.99431431
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.53674216
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.46640649
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22827287
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.10338786
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.08115590
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02331528
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.96836540
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.79562181
15* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.74399983
16RUNX_20019798_ChIP-Seq_JUKART_Human2.55065671
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.54751610
18SCL_19346495_ChIP-Seq_HPC-7_Human2.48355195
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.45923887
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.40740789
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37935275
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.32597307
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.29186385
24GATA1_22025678_ChIP-Seq_K562_Human2.25833539
25* MYB_26560356_Chip-Seq_TH2_Human2.23329276
26MAF_26560356_Chip-Seq_TH1_Human2.05098073
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.98065202
28* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88063209
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.86843471
30* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.82882468
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80377103
32* MYB_26560356_Chip-Seq_TH1_Human1.76290802
33VDR_24763502_ChIP-Seq_THP-1_Human1.76039583
34VDR_24787735_ChIP-Seq_THP-1_Human1.68208167
35* PU_27001747_Chip-Seq_BMDM_Mouse1.67380449
36* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62439939
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61372169
38SPI1_23547873_ChIP-Seq_NB4_Human1.60717648
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57400563
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56713751
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.55910428
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55330461
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.55201775
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.52712914
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49102649
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48439748
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.47336028
48VDR_21846776_ChIP-Seq_THP-1_Human1.43237781
49* UTX_26944678_Chip-Seq_JUKART_Human1.41173865
50GATA1_19941826_ChIP-Seq_K562_Human1.40351293
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39935609
52GATA3_27048872_Chip-Seq_THYMUS_Human1.39696431
53* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39002146
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38509936
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.36623459
56SPI1_23127762_ChIP-Seq_K562_Human1.34940127
57FOXM1_26456572_ChIP-Seq_MCF-7_Human1.34720662
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.32605344
59STAT3_23295773_ChIP-Seq_U87_Human1.32529219
60GATA2_19941826_ChIP-Seq_K562_Human1.31183620
61SALL4_18804426_ChIP-ChIP_XEN_Mouse1.30991166
62* ARNT_22903824_ChIP-Seq_MCF-7_Human1.30087759
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30066120
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29586898
65FUS_26573619_Chip-Seq_HEK293_Human1.29358756
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27440110
67ER_23166858_ChIP-Seq_MCF-7_Human1.27101447
68TCF7_22412390_ChIP-Seq_EML_Mouse1.26854338
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23879799
70TP63_23658742_ChIP-Seq_EP156T_Human1.22947739
71GBX2_23144817_ChIP-Seq_PC3_Human1.21811308
72AHR_22903824_ChIP-Seq_MCF-7_Human1.21524195
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21367922
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.19761216
75* GATA1_19941827_ChIP-Seq_MEL_Mouse1.19615395
76PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.19455304
77SMAD4_21799915_ChIP-Seq_A2780_Human1.19014434
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.18772167
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.18713882
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17095399
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16687231
82* BRD4_25478319_ChIP-Seq_HGPS_Human1.16007297
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14460214
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13543289
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13155343
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12523115
87* CJUN_26792858_Chip-Seq_BT549_Human1.12506716
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12418046
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11898694
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11551552
91CBP_20019798_ChIP-Seq_JUKART_Human1.11551552
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11537347
93TCF4_18268006_ChIP-ChIP_LS174T_Human1.11148770
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10968256
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10800232
96CDX2_22108803_ChIP-Seq_LS180_Human1.10486936
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.10268921
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09917039
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09183368
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08603548
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07794826
102AR_21572438_ChIP-Seq_LNCaP_Human1.07370668
103TRIM28_21343339_ChIP-Seq_HEK293_Human1.06929469
104* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06456223
105EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06364512
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06109268
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05712833
108MAF_26560356_Chip-Seq_TH2_Human1.05042109
109E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04701657
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04403996
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04254045
112E2F1_18555785_Chip-Seq_ESCs_Mouse1.04096573
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03648324
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03648324
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03402567
116* TCF4_23295773_ChIP-Seq_U87_Human1.03382593
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03356976
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.02537763
119* GATA3_26560356_Chip-Seq_TH2_Human1.02227584
120* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.01775176
121GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01505520
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01260455
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00625819
124* FOXA2_19822575_ChIP-Seq_HepG2_Human0.98881696
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98811786
126EGR1_19032775_ChIP-ChIP_M12_Human0.98518957
127SALL4_22934838_ChIP-ChIP_CD34+_Human0.98024144
128P300_19829295_ChIP-Seq_ESCs_Human0.97245802
129TAF15_26573619_Chip-Seq_HEK293_Human0.97194541
130OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96997835
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96943524
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96943524
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95795218
134SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95261050
135SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95261050
136* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95005397
137SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94699888
138WT1_19549856_ChIP-ChIP_CCG9911_Human0.94471879
139PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93156870
140PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93107139
141* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90980267
142RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90555915
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89843582
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88845649
145CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88414679
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86928170
147CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86697378
148ELK3_25401928_ChIP-Seq_HUVEC_Human0.85897214
149KDM2B_26808549_Chip-Seq_DND41_Human0.85645772
150GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85581416
151MYC_22102868_ChIP-Seq_BL_Human0.85194831
152KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83154235
153P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82392328
154FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82334427
155LXR_22158963_ChIP-Seq_LIVER_Mouse0.81869276
156CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80803656
157SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78221698
158SOX9_24532713_ChIP-Seq_HFSC_Mouse0.76589229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.66718213
2MP0001835_abnormal_antigen_presentation3.48370696
3MP0003646_muscle_fatigue3.47689932
4MP0009785_altered_susceptibility_to3.27652593
5MP0003724_increased_susceptibility_to2.91548736
6MP0003436_decreased_susceptibility_to2.83552341
7MP0003303_peritoneal_inflammation2.81531552
8MP0000569_abnormal_digit_pigmentation2.78880202
9MP0000685_abnormal_immune_system2.75004107
10MP0005671_abnormal_response_to2.73824491
11MP0005387_immune_system_phenotype2.73238435
12MP0001790_abnormal_immune_system2.73238435
13MP0005000_abnormal_immune_tolerance2.69679847
14MP0004036_abnormal_muscle_relaxation2.68950792
15MP0005025_abnormal_response_to2.63437881
16MP0002166_altered_tumor_susceptibility2.61318981
17MP0002148_abnormal_hypersensitivity_rea2.56904807
18MP0001800_abnormal_humoral_immune2.53333739
19MP0004084_abnormal_cardiac_muscle2.49640874
20MP0002419_abnormal_innate_immunity2.47312341
21MP0002452_abnormal_antigen_presenting2.38615841
22MP0005670_abnormal_white_adipose2.34781440
23MP0002723_abnormal_immune_serum2.34171754
24MP0006082_CNS_inflammation2.34081248
25MP0005410_abnormal_fertilization2.31558065
26MP0000749_muscle_degeneration2.24808381
27MP0002006_tumorigenesis2.21003453
28MP0001819_abnormal_immune_cell2.16174449
29MP0002420_abnormal_adaptive_immunity2.15593915
30MP0003656_abnormal_erythrocyte_physiolo2.09522069
31MP0003300_gastrointestinal_ulcer2.06985244
32MP0003763_abnormal_thymus_physiology2.03221177
33MP0004145_abnormal_muscle_electrophysio2.02287653
34MP0004947_skin_inflammation1.98287641
35MP0004381_abnormal_hair_follicle1.96971634
36MP0002009_preneoplasia1.94625910
37MP0004510_myositis1.90216284
38MP0004233_abnormal_muscle_weight1.86879260
39MP0002332_abnormal_exercise_endurance1.86585162
40MP0004484_altered_response_of1.83874620
41MP0010155_abnormal_intestine_physiology1.73798723
42MP0004087_abnormal_muscle_fiber1.73333469
43MP0002398_abnormal_bone_marrow1.73121895
44MP0005464_abnormal_platelet_physiology1.72070830
45MP0005666_abnormal_adipose_tissue1.71958590
46MP0002405_respiratory_system_inflammati1.70430386
47MP0000716_abnormal_immune_system1.69091291
48MP0002269_muscular_atrophy1.65441169
49MP0001845_abnormal_inflammatory_respons1.62497211
50MP0003448_altered_tumor_morphology1.60704620
51MP0001853_heart_inflammation1.60213617
52MP0010234_abnormal_vibrissa_follicle1.59129964
53MP0001533_abnormal_skeleton_physiology1.58764520
54MP0000759_abnormal_skeletal_muscle1.54102297
55MP0003221_abnormal_cardiomyocyte_apopto1.53655692
56MP0003705_abnormal_hypodermis_morpholog1.50286222
57MP0009278_abnormal_bone_marrow1.49724556
58MP0009764_decreased_sensitivity_to1.47951457
59MP0004147_increased_porphyrin_level1.47374497
60MP0009333_abnormal_splenocyte_physiolog1.46476165
61MP0000751_myopathy1.46164453
62MP0000343_altered_response_to1.44850431
63MP0003453_abnormal_keratinocyte_physiol1.43555054
64MP0002106_abnormal_muscle_physiology1.43533094
65MP0008260_abnormal_autophagy1.42798707
66MP0001545_abnormal_hematopoietic_system1.42422828
67MP0005397_hematopoietic_system_phenotyp1.42422828
68MP0008469_abnormal_protein_level1.41207281
69MP0001851_eye_inflammation1.40863856
70MP0000689_abnormal_spleen_morphology1.40184020
71MP0002722_abnormal_immune_system1.39512308
72MP0005058_abnormal_lysosome_morphology1.38979555
73MP0002429_abnormal_blood_cell1.38474631
74MP0000465_gastrointestinal_hemorrhage1.34663097
75MP0005375_adipose_tissue_phenotype1.32279260
76MP0009115_abnormal_fat_cell1.30968726
77MP0000747_muscle_weakness1.28548132
78MP0006138_congestive_heart_failure1.27176529
79MP0005620_abnormal_muscle_contractility1.27094659
80MP0000858_altered_metastatic_potential1.26657600
81MP0002933_joint_inflammation1.25808955
82MP0000383_abnormal_hair_follicle1.25616203
83MP0002998_abnormal_bone_remodeling1.23950097
84MP0003828_pulmonary_edema1.23485386
85MP0010630_abnormal_cardiac_muscle1.22281569
86MP0001873_stomach_inflammation1.21107445
87MP0002971_abnormal_brown_adipose1.20938878
88MP0005369_muscle_phenotype1.14861871
89MP0002396_abnormal_hematopoietic_system1.14145573
90MP0003136_yellow_coat_color1.12361774
91MP0002972_abnormal_cardiac_muscle1.10476063
92MP0002127_abnormal_cardiovascular_syste1.09428031
93MP0000703_abnormal_thymus_morphology1.05546577
94MP0004808_abnormal_hematopoietic_stem1.03738436
95MP0000920_abnormal_myelination1.03608779
96MP0005174_abnormal_tail_pigmentation1.02545303
97MP0002877_abnormal_melanocyte_morpholog0.99810242
98MP0010678_abnormal_skin_adnexa0.99573120
99MP0009763_increased_sensitivity_to0.96400341
100MP0005266_abnormal_metabolism0.95197137
101MP0004215_abnormal_myocardial_fiber0.93476057
102MP0005409_darkened_coat_color0.93046437
103MP0002138_abnormal_hepatobiliary_system0.92580226
104MP0005166_decreased_susceptibility_to0.92283789
105MP0003566_abnormal_cell_adhesion0.92117807
106MP0002108_abnormal_muscle_morphology0.89674152
107MP0003191_abnormal_cellular_cholesterol0.89625894
108MP0001879_abnormal_lymphatic_vessel0.89495480
109MP0000013_abnormal_adipose_tissue0.88735220
110MP0003866_abnormal_defecation0.88084979
111MP0003075_altered_response_to0.88017680
112MP0004185_abnormal_adipocyte_glucose0.87365908
113MP0004883_abnormal_blood_vessel0.87004939
114MP0002277_abnormal_respiratory_mucosa0.86017317
115MP0001661_extended_life_span0.84461218
116MP0005076_abnormal_cell_differentiation0.84383719
117MP0003950_abnormal_plasma_membrane0.84324394
118MP0005310_abnormal_salivary_gland0.83360075
119MP0001216_abnormal_epidermal_layer0.82619690
120MP0002168_other_aberrant_phenotype0.82488258
121MP0003690_abnormal_glial_cell0.82289188
122MP0005330_cardiomyopathy0.79499038
123MP0000490_abnormal_crypts_of0.79032745
124MP0004130_abnormal_muscle_cell0.78182939
125MP0000003_abnormal_adipose_tissue0.77724047
126MP0003183_abnormal_peptide_metabolism0.76173129
127MP0002254_reproductive_system_inflammat0.75442826
128MP0005451_abnormal_body_composition0.75249384
129MP0005385_cardiovascular_system_phenoty0.74901442
130MP0001544_abnormal_cardiovascular_syste0.74901442
131MP0003045_fibrosis0.74754645
132MP0005023_abnormal_wound_healing0.73949848
133MP0004264_abnormal_extraembryonic_tissu0.73518828
134MP0005275_abnormal_skin_tensile0.72978092
135MP0000249_abnormal_blood_vessel0.72421119
136MP0005390_skeleton_phenotype0.71868967
137MP0003091_abnormal_cell_migration0.71848139
138MP0009697_abnormal_copulation0.70105969
139MP0001191_abnormal_skin_condition0.69759061
140MP0009931_abnormal_skin_appearance0.69501138
141MP0002796_impaired_skin_barrier0.68673547
142MP0000767_abnormal_smooth_muscle0.68480963
143MP0005164_abnormal_response_to0.67217396
144MP0009840_abnormal_foam_cell0.66554634
145MP0010352_gastrointestinal_tract_polyps0.66231688
146MP0008438_abnormal_cutaneous_collagen0.65182459
147MP0000733_abnormal_muscle_development0.64636544
148MP0010307_abnormal_tumor_latency0.64586445
149MP0001663_abnormal_digestive_system0.64377198
150MP0000372_irregular_coat_pigmentation0.64286433

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)6.10161506
2Muscle fiber inclusion bodies (HP:0100299)6.04237011
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.87390884
4Eczematoid dermatitis (HP:0000976)5.31125969
5Recurrent abscess formation (HP:0002722)4.72841647
6Type 1 muscle fiber predominance (HP:0003803)4.38137317
7Recurrent bacterial skin infections (HP:0005406)4.30497740
8Exercise-induced myalgia (HP:0003738)4.25037613
9Subaortic stenosis (HP:0001682)4.15870114
10Abnormality of the left ventricular outflow tract (HP:0011103)4.15870114
11Chronic otitis media (HP:0000389)3.99529671
12Recurrent fungal infections (HP:0002841)3.94869311
13Hyperkalemia (HP:0002153)3.89071979
14Asymmetric septal hypertrophy (HP:0001670)3.85395568
15Recurrent viral infections (HP:0004429)3.79167452
16Stomatitis (HP:0010280)3.75435547
17Myositis (HP:0100614)3.73543944
18Abnormality of macrophages (HP:0004311)3.73178381
19Autoimmune thrombocytopenia (HP:0001973)3.72882766
20Elevated erythrocyte sedimentation rate (HP:0003565)3.70396112
21Recurrent gram-negative bacterial infections (HP:0005420)3.69373743
22Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.62927318
23Papillary thyroid carcinoma (HP:0002895)3.54618155
24Recurrent skin infections (HP:0001581)3.53896485
25Spontaneous hematomas (HP:0007420)3.53131574
26Mediastinal lymphadenopathy (HP:0100721)3.47963088
27Chronic mucocutaneous candidiasis (HP:0002728)3.44317369
28Recurrent cutaneous fungal infections (HP:0011370)3.44317369
29Calf muscle hypertrophy (HP:0008981)3.38376096
30Vasculitis (HP:0002633)3.38106818
31Orchitis (HP:0100796)3.32689211
32Chronic obstructive pulmonary disease (HP:0006510)3.30511590
33Obstructive lung disease (HP:0006536)3.30511590
34Optic neuritis (HP:0100653)3.25697168
35Retrobulbar optic neuritis (HP:0100654)3.25697168
36Difficulty running (HP:0009046)3.23369647
37Distal arthrogryposis (HP:0005684)3.18964362
38Abnormality of T cell number (HP:0011839)3.18378724
39Cellulitis (HP:0100658)3.14351139
40T lymphocytopenia (HP:0005403)3.13644958
41Increased IgE level (HP:0003212)3.07920905
42Meningitis (HP:0001287)3.07702525
43Recurrent bronchitis (HP:0002837)3.06394662
44Nasal polyposis (HP:0100582)3.01395683
45Abnormality of the nasal mucosa (HP:0000433)2.99972331
46EMG: myopathic abnormalities (HP:0003458)2.98891658
47Muscle fiber splitting (HP:0003555)2.97910712
48Thick nail (HP:0001805)2.92201409
49Myocardial infarction (HP:0001658)2.90879511
50Pustule (HP:0200039)2.88290700
51Autoimmune hemolytic anemia (HP:0001890)2.87664876
52Inflammation of the large intestine (HP:0002037)2.84946445
53Prostate neoplasm (HP:0100787)2.81057967
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.71154984
55Resting tremor (HP:0002322)2.69582174
56Eosinophilia (HP:0001880)2.63142102
57Gingival bleeding (HP:0000225)2.61825648
58Hemoptysis (HP:0002105)2.60313914
59Vacuolated lymphocytes (HP:0001922)2.59502633
60Frequent falls (HP:0002359)2.58180528
61Centrally nucleated skeletal muscle fibers (HP:0003687)2.58078474
62Gingivitis (HP:0000230)2.57741592
63Hematochezia (HP:0002573)2.56727583
64Abnormality of the fingertips (HP:0001211)2.56688807
65Bundle branch block (HP:0011710)2.55935676
66Osteolytic defects of the hand bones (HP:0009699)2.55723782
67Osteolytic defects of the phalanges of the hand (HP:0009771)2.55723782
68Interstitial pulmonary disease (HP:0006530)2.55593939
69Urticaria (HP:0001025)2.55266125
70Abnormality of skeletal muscle fiber size (HP:0012084)2.55185643
71Abnormality of T cells (HP:0002843)2.54479397
72Menstrual irregularities (HP:0000858)2.52426501
73Gastrointestinal inflammation (HP:0004386)2.51868580
74Increased connective tissue (HP:0009025)2.51859337
75Agammaglobulinemia (HP:0004432)2.51828344
76Gastrointestinal infarctions (HP:0005244)2.50784640
77Rhabdomyolysis (HP:0003201)2.49060434
78Ventricular tachycardia (HP:0004756)2.48392176
79Neck muscle weakness (HP:0000467)2.47218865
80Colitis (HP:0002583)2.46378117
81Subacute progressive viral hepatitis (HP:0006572)2.46086603
82Prolonged bleeding time (HP:0003010)2.45794576
83Acute myeloid leukemia (HP:0004808)2.44483426
84Abnormality of the calf musculature (HP:0001430)2.43623172
85Leukocytosis (HP:0001974)2.43413735
86Microcytic anemia (HP:0001935)2.42651321
87Truncal obesity (HP:0001956)2.40765499
88Hypergammaglobulinemia (HP:0010702)2.38091637
89Osteomyelitis (HP:0002754)2.37904831
90Epistaxis (HP:0000421)2.37448913
91Arterial thrombosis (HP:0004420)2.36113612
92Keratoconjunctivitis sicca (HP:0001097)2.32454091
93Myoglobinuria (HP:0002913)2.32379086
94Pulmonary infiltrates (HP:0002113)2.32074280
95IgM deficiency (HP:0002850)2.31983997
96Periodontitis (HP:0000704)2.29570763
97Parakeratosis (HP:0001036)2.29552550
98Dysmetric saccades (HP:0000641)2.28763100
99Axonal loss (HP:0003447)2.28091222
100Pulmonary embolism (HP:0002204)2.27976084
101Cone-rod dystrophy (HP:0000548)2.27513082
102Ulnar deviation of the wrist (HP:0003049)2.27428812
103Abnormality of T cell physiology (HP:0011840)2.26636695
104Increased variability in muscle fiber diameter (HP:0003557)2.26324244
105Gastrointestinal stroma tumor (HP:0100723)2.22861791
106Panhypogammaglobulinemia (HP:0003139)2.21987303
107Basal ganglia calcification (HP:0002135)2.21361830
108Increased IgM level (HP:0003496)2.19464385
109Fatigue (HP:0012378)2.18931622
110Petechiae (HP:0000967)2.17818227
111Abnormality of the prostate (HP:0008775)2.17165131
112Gangrene (HP:0100758)2.15739184
113Chest pain (HP:0100749)2.15058246
114Encephalitis (HP:0002383)2.13344366
115Abnormality of eosinophils (HP:0001879)2.12434479
116Chronic sinusitis (HP:0011109)2.12324809
117Purpura (HP:0000979)2.12225244
118Keratoconjunctivitis (HP:0001096)2.12098253
119Sudden death (HP:0001699)2.12017216
120Skin ulcer (HP:0200042)2.10908617
121Hypoalphalipoproteinemia (HP:0003233)2.10494177
122Thyroiditis (HP:0100646)2.10480770
123Round ear (HP:0100830)2.09864125
124Granulocytopenia (HP:0001913)2.08781053
125Aortic aneurysm (HP:0004942)2.03488774
126Hepatosplenomegaly (HP:0001433)2.01186867
127Rimmed vacuoles (HP:0003805)1.99761834
128Overgrowth (HP:0001548)1.99414598
129Abnormal platelet volume (HP:0011876)1.98714430
130Abnormality of the ischium (HP:0003174)1.97125146
131Poikilocytosis (HP:0004447)1.97069304
132Chronic diarrhea (HP:0002028)1.96556740
133Increased serum ferritin (HP:0003281)1.96073375
134Malignant hyperthermia (HP:0002047)1.95923232
135Sepsis (HP:0100806)1.94674688
136Areflexia of lower limbs (HP:0002522)1.91803083
137Peritonitis (HP:0002586)1.91665354
138Verrucae (HP:0200043)1.90972621
139Papilloma (HP:0012740)1.90972621
140Esophageal varix (HP:0002040)1.89864310
141Recurrent lower respiratory tract infections (HP:0002783)1.89778164
142Recurrent pneumonia (HP:0006532)1.88819736
143Systemic lupus erythematosus (HP:0002725)1.88037536
144Exercise-induced muscle cramps (HP:0003710)1.87974378
145Lymphopenia (HP:0001888)1.87701142
146Distal lower limb muscle weakness (HP:0009053)1.85946880
147Muscle hypertrophy of the lower extremities (HP:0008968)1.83703543
148Hyporeflexia of lower limbs (HP:0002600)1.83022631
149Abnormality of cells of the lymphoid lineage (HP:0012140)1.82979177
150Facial diplegia (HP:0001349)1.82722347
151Hypoplastic ischia (HP:0003175)1.81500561
152Conjunctival telangiectasia (HP:0000524)1.81092846
153Distal lower limb amyotrophy (HP:0008944)1.80947218
154Tubulointerstitial nephritis (HP:0001970)1.80633995
155Myopathic facies (HP:0002058)1.80344064
156Portal hypertension (HP:0001409)1.79394223
157Biliary tract neoplasm (HP:0100574)1.78652791
158Abnormal finger flexion creases (HP:0006143)1.77751799
159Sandal gap (HP:0001852)1.76899318
160Right ventricular cardiomyopathy (HP:0011663)1.76855408
161Fair hair (HP:0002286)1.76737588
162Abnormality of potassium homeostasis (HP:0011042)1.74770029
163EMG: neuropathic changes (HP:0003445)1.74105656
164Abnormality of the vasculature of the conjunctiva (HP:0008054)1.73929165
165Thyroid carcinoma (HP:0002890)1.73746731
166Long clavicles (HP:0000890)1.71884419
167Cystic hygroma (HP:0000476)1.67434463
168Postural instability (HP:0002172)1.66521214
169Insulin-resistant diabetes mellitus (HP:0000831)1.66291848
170Thickened calvaria (HP:0002684)1.62583617
171Viral hepatitis (HP:0006562)1.60714110
172Prominent nose (HP:0000448)1.59864542
173Generalized muscle weakness (HP:0003324)1.59457959
174Increased CSF protein (HP:0002922)1.58617933
175Dilated cardiomyopathy (HP:0001644)1.58484768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.37675289
2MAP3K142.80459175
3TXK2.68927740
4TYK22.67517353
5BRD42.65695914
6EPHB12.64901822
7JAK32.49775772
8IKBKE2.44566057
9BLK2.42983733
10PBK2.40357298
11TBK12.35437723
12IRAK42.34542661
13CLK12.26708926
14STK102.15009177
15CDK122.13002005
16PLK42.11900454
17STK38L2.04644106
18MST42.02198235
19JAK12.02126112
20LATS11.96635800
21RIPK41.81733295
22CAMK1G1.77865482
23MAP3K21.76831619
24FGFR41.75106928
25TGFBR21.74565298
26IRAK31.73782131
27AKT31.72794765
28CSK1.67291955
29EPHA31.63309561
30KIT1.60753162
31NLK1.59661952
32IKBKB1.59062836
33TTN1.57651330
34ZAP701.54932184
35TEC1.52624442
36FGFR31.52439634
37ITK1.51478240
38NME21.48332310
39SGK21.47673445
40TRPM71.46613689
41BTK1.43507359
42NEK91.40461709
43SGK31.40084261
44KSR21.40044241
45STK381.37885811
46STK41.37219050
47STK391.32102190
48LCK1.26628205
49FGR1.24444323
50PIM11.23833240
51SYK1.20552659
52GRK61.19272994
53HCK1.18506639
54ACVR1B1.16598592
55MAP3K131.16478659
56LRRK21.13610796
57JAK21.13387817
58EEF2K1.11809847
59PRPF4B1.08896457
60TAOK31.07259720
61IRAK11.04109009
62PRKCQ1.03789899
63PRKAA21.03420032
64MAP2K30.98595844
65NEK60.98008488
66DMPK0.97434994
67ERN10.94389500
68MARK30.93681659
69MAP3K60.91949689
70BMPR20.89108197
71CSF1R0.88217568
72PHKG20.87882631
73PHKG10.87882631
74PTK2B0.87759475
75MAP3K100.87582277
76LYN0.87297578
77TLK10.85283768
78MELK0.85230301
79PRKD20.85181776
80CHUK0.84035825
81HIPK20.82982310
82CDK60.82386195
83OBSCN0.81404840
84PIM20.79049797
85NUAK10.76861443
86PDPK10.74619962
87MST1R0.73870780
88TNK20.73680082
89BRSK20.72337260
90MAPK70.71868022
91PNCK0.71441319
92GRK70.71040788
93MAPKAPK50.70899474
94EIF2AK30.69163827
95PDGFRA0.68474537
96SGK4940.67938334
97SGK2230.67938334
98RAF10.67741691
99MAPK120.67618757
100FES0.65872323
101RPS6KA50.65155574
102PKN10.61358198
103KDR0.60933740
104STK30.60872120
105MARK20.60686315
106ABL10.57783527
107SGK10.57601771
108RPS6KA40.56012684
109FGFR20.53768798
110RET0.53583197
111MAP2K40.53190554
112PLK20.53171221
113MAPKAPK20.52741762
114EIF2AK20.51911627
115PRKD10.51850590
116CAMK40.51423233
117MAP3K70.50786329
118RPS6KB20.49076739
119DYRK1B0.48269070
120PIK3CG0.47745901
121PTK60.45755397
122PDGFRB0.45440128
123IRAK20.45179202
124FRK0.44204894
125MTOR0.44113824
126EIF2AK10.44094970
127BMX0.42244211
128PIK3CA0.42078825
129EGFR0.41356351
130PDK10.39908340
131TIE10.39864757
132CDK40.39528898
133MAPK110.39081211
134WNK10.38734656
135STK240.38686969
136PRKG20.38584595
137MAP3K10.38348991
138MAP3K30.37969012
139YES10.37847408
140MAPK40.37219471
141OXSR10.36820253
142CAMK1D0.35760389
143KSR10.35627634
144MAP3K110.35096414
145PKN20.34983696
146MOS0.33996391
147FYN0.33492255
148GSK3A0.33026317

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.86688289
2Graft-versus-host disease_Homo sapiens_hsa053322.82074060
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.63413164
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.61086873
5Measles_Homo sapiens_hsa051622.61047329
6Primary immunodeficiency_Homo sapiens_hsa053402.46842833
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.36900039
8Staphylococcus aureus infection_Homo sapiens_hsa051502.34120774
9Malaria_Homo sapiens_hsa051442.33519579
10Osteoclast differentiation_Homo sapiens_hsa043802.32064547
11Allograft rejection_Homo sapiens_hsa053302.27781198
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.24899123
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.15423703
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.04367127
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98399243
16B cell receptor signaling pathway_Homo sapiens_hsa046621.96518650
17Hematopoietic cell lineage_Homo sapiens_hsa046401.95305316
18Fatty acid biosynthesis_Homo sapiens_hsa000611.88786239
19Antigen processing and presentation_Homo sapiens_hsa046121.88169979
20Pertussis_Homo sapiens_hsa051331.81951696
21Toxoplasmosis_Homo sapiens_hsa051451.80513230
22Influenza A_Homo sapiens_hsa051641.65441650
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.64581532
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63549094
25T cell receptor signaling pathway_Homo sapiens_hsa046601.63174751
26Herpes simplex infection_Homo sapiens_hsa051681.60684136
27TNF signaling pathway_Homo sapiens_hsa046681.60484858
28Non-small cell lung cancer_Homo sapiens_hsa052231.59959442
29Legionellosis_Homo sapiens_hsa051341.59935625
30Asthma_Homo sapiens_hsa053101.58655518
31Tuberculosis_Homo sapiens_hsa051521.58512224
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.50891684
33Circadian rhythm_Homo sapiens_hsa047101.47700698
34Autoimmune thyroid disease_Homo sapiens_hsa053201.43331961
35Salmonella infection_Homo sapiens_hsa051321.42056058
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.38789636
37Viral myocarditis_Homo sapiens_hsa054161.38733919
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.38253781
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37826041
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.37162630
41Chemokine signaling pathway_Homo sapiens_hsa040621.36721896
42mTOR signaling pathway_Homo sapiens_hsa041501.31893547
43Insulin signaling pathway_Homo sapiens_hsa049101.24451403
44Hepatitis B_Homo sapiens_hsa051611.22695768
45Endometrial cancer_Homo sapiens_hsa052131.21021806
46Hepatitis C_Homo sapiens_hsa051601.20353615
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18432687
48Rheumatoid arthritis_Homo sapiens_hsa053231.17149542
49Apoptosis_Homo sapiens_hsa042101.16247977
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14468791
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14092310
52Shigellosis_Homo sapiens_hsa051311.12638968
53African trypanosomiasis_Homo sapiens_hsa051431.12358043
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11252525
55Caffeine metabolism_Homo sapiens_hsa002321.07389997
56Thyroid cancer_Homo sapiens_hsa052161.05753088
57Acute myeloid leukemia_Homo sapiens_hsa052211.05733215
58Type II diabetes mellitus_Homo sapiens_hsa049301.00303290
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00265723
60Glioma_Homo sapiens_hsa052140.99837775
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99525063
62Long-term potentiation_Homo sapiens_hsa047200.96916477
63Platelet activation_Homo sapiens_hsa046110.96533206
64Dilated cardiomyopathy_Homo sapiens_hsa054140.96306452
65Systemic lupus erythematosus_Homo sapiens_hsa053220.92861880
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92791897
67Small cell lung cancer_Homo sapiens_hsa052220.91947896
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90415593
69Colorectal cancer_Homo sapiens_hsa052100.89385957
70Glucagon signaling pathway_Homo sapiens_hsa049220.88168909
71ErbB signaling pathway_Homo sapiens_hsa040120.85172547
72GnRH signaling pathway_Homo sapiens_hsa049120.84481042
73Choline metabolism in cancer_Homo sapiens_hsa052310.84347124
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.83321922
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82327461
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.81621369
77Renin secretion_Homo sapiens_hsa049240.80700755
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79630805
79Chronic myeloid leukemia_Homo sapiens_hsa052200.77554325
80Amoebiasis_Homo sapiens_hsa051460.77341437
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77291611
82Lysosome_Homo sapiens_hsa041420.76503044
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75686290
84Oxytocin signaling pathway_Homo sapiens_hsa049210.72989207
85Phagosome_Homo sapiens_hsa041450.71439252
86Pancreatic cancer_Homo sapiens_hsa052120.70655000
87Estrogen signaling pathway_Homo sapiens_hsa049150.67735408
88AMPK signaling pathway_Homo sapiens_hsa041520.67264325
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66273156
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.65566094
91Viral carcinogenesis_Homo sapiens_hsa052030.64366492
92ABC transporters_Homo sapiens_hsa020100.63938554
93Tight junction_Homo sapiens_hsa045300.62759154
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62038592
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.61873412
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61123755
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60760629
98Long-term depression_Homo sapiens_hsa047300.59138061
99Prostate cancer_Homo sapiens_hsa052150.59050049
100Ether lipid metabolism_Homo sapiens_hsa005650.58768100
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57196526
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54575716
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52941482
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52013113
105Complement and coagulation cascades_Homo sapiens_hsa046100.51829978
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.51777171
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51683467
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.51593578
109Insulin resistance_Homo sapiens_hsa049310.51398527
110Other glycan degradation_Homo sapiens_hsa005110.48873087
111VEGF signaling pathway_Homo sapiens_hsa043700.47201467
112Proteoglycans in cancer_Homo sapiens_hsa052050.46064717
113Adherens junction_Homo sapiens_hsa045200.45651214
114Endocytosis_Homo sapiens_hsa041440.45592467
115Focal adhesion_Homo sapiens_hsa045100.45005512
116Prolactin signaling pathway_Homo sapiens_hsa049170.44568203
117Type I diabetes mellitus_Homo sapiens_hsa049400.43453327
118Sphingolipid metabolism_Homo sapiens_hsa006000.42850224
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42141894
120Dorso-ventral axis formation_Homo sapiens_hsa043200.41262110
121ECM-receptor interaction_Homo sapiens_hsa045120.41021574
122FoxO signaling pathway_Homo sapiens_hsa040680.40389814
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39003841
124HTLV-I infection_Homo sapiens_hsa051660.38126894
125Epstein-Barr virus infection_Homo sapiens_hsa051690.37403769
126MicroRNAs in cancer_Homo sapiens_hsa052060.37195326
127HIF-1 signaling pathway_Homo sapiens_hsa040660.35416085
128Renal cell carcinoma_Homo sapiens_hsa052110.33150487
129Mineral absorption_Homo sapiens_hsa049780.31010826
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30351600
131Inositol phosphate metabolism_Homo sapiens_hsa005620.28314534
132PPAR signaling pathway_Homo sapiens_hsa033200.28173030
133Pathways in cancer_Homo sapiens_hsa052000.26367954
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23613158
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.23455965
136MAPK signaling pathway_Homo sapiens_hsa040100.22737573

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