USP26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.95945079
2DNA methylation involved in gamete generation (GO:0043046)7.11779289
3regulation of meiosis I (GO:0060631)6.51919127
4synaptonemal complex assembly (GO:0007130)5.44895164
5male meiosis (GO:0007140)5.09763516
6synaptonemal complex organization (GO:0070193)4.90241269
7meiotic nuclear division (GO:0007126)4.55646004
8chromosome organization involved in meiosis (GO:0070192)4.46486605
9nuclear pore complex assembly (GO:0051292)4.40514247
10DNA replication checkpoint (GO:0000076)4.37554672
11heterochromatin organization (GO:0070828)4.30848990
12behavioral response to nicotine (GO:0035095)4.30055675
13meiotic chromosome segregation (GO:0045132)4.27498959
14ribosomal small subunit biogenesis (GO:0042274)4.27119308
15reciprocal DNA recombination (GO:0035825)4.23502927
16reciprocal meiotic recombination (GO:0007131)4.23502927
17neural tube formation (GO:0001841)4.23016289
18nuclear pore organization (GO:0006999)4.21843400
19histone H4-K12 acetylation (GO:0043983)4.19583000
20DNA alkylation (GO:0006305)4.13525924
21DNA methylation (GO:0006306)4.13525924
22indolalkylamine metabolic process (GO:0006586)4.12549010
23cellular ketone body metabolic process (GO:0046950)4.08824311
24regulation of glucokinase activity (GO:0033131)4.07103165
25regulation of hexokinase activity (GO:1903299)4.07103165
26ubiquinone biosynthetic process (GO:0006744)4.06472899
27attachment of spindle microtubules to kinetochore (GO:0008608)4.01468205
28regulation of nuclear cell cycle DNA replication (GO:0033262)3.98495512
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.96611383
30kinetochore assembly (GO:0051382)3.96599748
31maturation of SSU-rRNA (GO:0030490)3.94646744
32male meiosis I (GO:0007141)3.92141801
33DNA replication-dependent nucleosome assembly (GO:0006335)3.91601363
34DNA replication-dependent nucleosome organization (GO:0034723)3.91601363
35L-fucose catabolic process (GO:0042355)3.91332533
36fucose catabolic process (GO:0019317)3.91332533
37L-fucose metabolic process (GO:0042354)3.91332533
38positive regulation of meiosis (GO:0045836)3.88680414
39kinetochore organization (GO:0051383)3.88034296
40preassembly of GPI anchor in ER membrane (GO:0016254)3.78164889
41ubiquinone metabolic process (GO:0006743)3.77307458
42positive regulation of meiotic cell cycle (GO:0051446)3.71702432
43regulation of double-strand break repair via homologous recombination (GO:0010569)3.69471264
44DNA replication initiation (GO:0006270)3.68277258
45protein K6-linked ubiquitination (GO:0085020)3.66399898
46oogenesis (GO:0048477)3.64225340
47platelet dense granule organization (GO:0060155)3.64107188
48protein K11-linked deubiquitination (GO:0035871)3.63982088
49kidney morphogenesis (GO:0060993)3.62504924
50ketone body metabolic process (GO:1902224)3.59651513
51replication fork processing (GO:0031297)3.55555548
52sister chromatid cohesion (GO:0007062)3.51311563
53pore complex assembly (GO:0046931)3.46452717
54viral transcription (GO:0019083)3.41770603
55daunorubicin metabolic process (GO:0044597)3.41711813
56polyketide metabolic process (GO:0030638)3.41711813
57doxorubicin metabolic process (GO:0044598)3.41711813
58DNA methylation or demethylation (GO:0044728)3.40528518
59regulation of gene silencing by RNA (GO:0060966)3.38761822
60regulation of posttranscriptional gene silencing (GO:0060147)3.38761822
61regulation of gene silencing by miRNA (GO:0060964)3.38761822
62detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.33419587
63regulation of double-strand break repair (GO:2000779)3.29246966
64quinone biosynthetic process (GO:1901663)3.29028900
65translational termination (GO:0006415)3.28578185
66chromatin remodeling at centromere (GO:0031055)3.27622589
67response to pheromone (GO:0019236)3.26719527
68dopamine transport (GO:0015872)3.26656572
69meiotic cell cycle process (GO:1903046)3.26599741
70regulation of male gonad development (GO:2000018)3.25473057
71positive regulation of male gonad development (GO:2000020)3.21855272
72proline transport (GO:0015824)3.21850069
73indole-containing compound metabolic process (GO:0042430)3.21802823
74meiosis I (GO:0007127)3.21340055
75ribosomal large subunit biogenesis (GO:0042273)3.21132044
76indole-containing compound catabolic process (GO:0042436)3.17335961
77indolalkylamine catabolic process (GO:0046218)3.17335961
78tryptophan catabolic process (GO:0006569)3.17335961
79inner cell mass cell proliferation (GO:0001833)3.17312105
80inner ear receptor stereocilium organization (GO:0060122)3.16970012
81ribosomal small subunit assembly (GO:0000028)3.16630417
82epithelial cilium movement (GO:0003351)3.16587922
83oocyte development (GO:0048599)3.16187085
84gene silencing by RNA (GO:0031047)3.15522594
85telomere maintenance via semi-conservative replication (GO:0032201)3.15404156
86intra-S DNA damage checkpoint (GO:0031573)3.14797358
87negative regulation of meiosis (GO:0045835)3.14061124
88regulation of mammary gland epithelial cell proliferation (GO:0033599)3.13500587
89chromatin assembly (GO:0031497)3.13149464
90ribonucleoprotein complex biogenesis (GO:0022613)3.11722717
91synapsis (GO:0007129)3.11553366
92regulation of helicase activity (GO:0051095)3.10822264
93recombinational repair (GO:0000725)3.09051174
94double-strand break repair via homologous recombination (GO:0000724)3.08913229
95DNA synthesis involved in DNA repair (GO:0000731)3.05948707
96DNA ligation (GO:0006266)3.03879902
97negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01182083
98histone H4-K5 acetylation (GO:0043981)2.99765903
99histone H4-K8 acetylation (GO:0043982)2.99765903
100kynurenine metabolic process (GO:0070189)2.98829210
101tryptophan metabolic process (GO:0006568)2.98475565
102auditory receptor cell stereocilium organization (GO:0060088)2.98453827
103female gamete generation (GO:0007292)2.98111628
104water-soluble vitamin biosynthetic process (GO:0042364)2.95872417
105DNA modification (GO:0006304)2.95864247
106GPI anchor metabolic process (GO:0006505)2.95612663
107telomere maintenance via recombination (GO:0000722)2.94817423
108axoneme assembly (GO:0035082)2.93178014
109behavioral response to ethanol (GO:0048149)2.91608477
110mitotic chromosome condensation (GO:0007076)2.90152893
111DNA deamination (GO:0045006)2.90061776
112embryonic epithelial tube formation (GO:0001838)2.89399172
113DNA strand elongation involved in DNA replication (GO:0006271)2.89078200
114negative regulation of telomere maintenance (GO:0032205)2.88781936
115regulation of histone H3-K9 methylation (GO:0051570)2.87728362
116protein localization to kinetochore (GO:0034501)2.86972864
117photoreceptor cell maintenance (GO:0045494)2.86029247
118signal peptide processing (GO:0006465)2.85980374
119DNA damage response, detection of DNA damage (GO:0042769)2.85912689
120nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.85403169
121C-terminal protein lipidation (GO:0006501)2.84134404
122maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.82893631
123rRNA modification (GO:0000154)2.82359498
124interkinetic nuclear migration (GO:0022027)2.82234951
125CENP-A containing nucleosome assembly (GO:0034080)2.82225726
126mitotic recombination (GO:0006312)2.82136184
127pyrimidine nucleobase catabolic process (GO:0006208)2.80728327
128mannosylation (GO:0097502)2.80206898
129negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.79545549
130DNA replication-independent nucleosome organization (GO:0034724)2.78660607
131DNA replication-independent nucleosome assembly (GO:0006336)2.78660607
132mitotic sister chromatid segregation (GO:0000070)2.78069825
133C-terminal protein amino acid modification (GO:0018410)2.77646038
134RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76137124
135tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76137124
136retinal cone cell development (GO:0046549)2.76129497
137negative regulation of DNA-dependent DNA replication (GO:2000104)2.74758712
138cilium morphogenesis (GO:0060271)2.74706089
139DNA strand elongation (GO:0022616)2.74529311
140regulation of telomere maintenance via telomerase (GO:0032210)2.74051726
141negative regulation of cell cycle G2/M phase transition (GO:1902750)2.73452701
142anterograde synaptic vesicle transport (GO:0048490)2.72661020
143pseudouridine synthesis (GO:0001522)2.72290688
144SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.71305661
145positive regulation of translational initiation (GO:0045948)2.70769158
146metaphase plate congression (GO:0051310)2.70712558
147primary amino compound metabolic process (GO:1901160)2.69856012
148somatic diversification of immune receptors via somatic mutation (GO:0002566)2.69804059
149somatic hypermutation of immunoglobulin genes (GO:0016446)2.69804059
150DNA double-strand break processing (GO:0000729)2.69617731
151ribosome biogenesis (GO:0042254)2.67846333
152epithelial tube formation (GO:0072175)2.67621370
153chromatin assembly or disassembly (GO:0006333)2.67552226
154RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.65314540
155cotranslational protein targeting to membrane (GO:0006613)2.64507329
156regulation of histone H3-K27 methylation (GO:0061085)2.64327206
157spindle assembly checkpoint (GO:0071173)2.63390183
158meiotic cell cycle (GO:0051321)2.63340881
159histone exchange (GO:0043486)2.63278374
160proteasome assembly (GO:0043248)2.62858419
161protein localization to chromosome, centromeric region (GO:0071459)2.62777600
162protein targeting to ER (GO:0045047)2.62487726
163cilium movement (GO:0003341)2.61236294
164acrosome assembly (GO:0001675)2.58593715
165respiratory chain complex IV assembly (GO:0008535)2.56530456
166positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.55831676
167regulation of telomere maintenance (GO:0032204)2.55147047
168tachykinin receptor signaling pathway (GO:0007217)2.54054263
169cellular biogenic amine catabolic process (GO:0042402)2.53933458
170amine catabolic process (GO:0009310)2.53933458
171S-adenosylmethionine metabolic process (GO:0046500)2.53322632
172G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52569258
173forebrain morphogenesis (GO:0048853)2.52208608
174glycolipid biosynthetic process (GO:0009247)2.50381796
175cilium organization (GO:0044782)2.48410863
176glycerophospholipid catabolic process (GO:0046475)2.48206375
177cytochrome complex assembly (GO:0017004)2.48037616
178serotonin metabolic process (GO:0042428)2.47952592
179regulation of rhodopsin mediated signaling pathway (GO:0022400)2.45616323
180GPI anchor biosynthetic process (GO:0006506)2.45446715
181negative regulation of mast cell activation (GO:0033004)2.44556027
182protein neddylation (GO:0045116)2.44388134
183rhodopsin mediated signaling pathway (GO:0016056)2.43008581
184magnesium ion transport (GO:0015693)2.42960848
185nucleobase catabolic process (GO:0046113)2.41647121
186parental behavior (GO:0060746)2.41244212
187cilium assembly (GO:0042384)2.40899851
188adaptation of signaling pathway (GO:0023058)2.39766618
189rRNA catabolic process (GO:0016075)2.39290182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.28485518
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.28418652
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.28418652
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.28418652
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.81476504
6ZNF274_21170338_ChIP-Seq_K562_Hela3.63777221
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.48158394
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.42270938
9VDR_22108803_ChIP-Seq_LS180_Human3.39425022
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.30983729
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.03853441
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.95331564
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.77237774
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.75710368
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.63999150
16GBX2_23144817_ChIP-Seq_PC3_Human2.61400887
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56338330
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.43443823
19FUS_26573619_Chip-Seq_HEK293_Human2.42744636
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32451777
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31834293
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.31650750
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26821742
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.22747207
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20204639
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17424877
27P300_19829295_ChIP-Seq_ESCs_Human2.16659597
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.15899741
29EWS_26573619_Chip-Seq_HEK293_Human2.14755432
30EST1_17652178_ChIP-ChIP_JURKAT_Human2.14389536
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12469210
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.08932799
33NOTCH1_21737748_ChIP-Seq_TLL_Human2.01007870
34CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00645707
35TAF15_26573619_Chip-Seq_HEK293_Human1.99391461
36IGF1R_20145208_ChIP-Seq_DFB_Human1.99202259
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97409346
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.91802018
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89960880
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89032181
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87702046
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87014227
43ER_23166858_ChIP-Seq_MCF-7_Human1.86157871
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82743949
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81372480
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80347329
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78035068
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74034207
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70744311
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69762250
51BCAT_22108803_ChIP-Seq_LS180_Human1.68461423
52SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65353326
53VDR_23849224_ChIP-Seq_CD4+_Human1.64042222
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62538422
55IRF1_19129219_ChIP-ChIP_H3396_Human1.62374437
56NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.62100864
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.61986950
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60840067
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.60491597
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.59616372
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58097287
62CBP_20019798_ChIP-Seq_JUKART_Human1.58097287
63RNF2_27304074_Chip-Seq_NSC_Mouse1.57570116
64TCF4_23295773_ChIP-Seq_U87_Human1.56019359
65TTF2_22483619_ChIP-Seq_HELA_Human1.54362172
66STAT3_23295773_ChIP-Seq_U87_Human1.54228132
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54172919
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54037089
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53902044
70AR_25329375_ChIP-Seq_VCAP_Human1.53894748
71SMAD4_21799915_ChIP-Seq_A2780_Human1.52852391
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52625353
73XRN2_22483619_ChIP-Seq_HELA_Human1.51977752
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49641346
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.49619184
76TCF4_22108803_ChIP-Seq_LS180_Human1.49373554
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49251455
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48194560
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47088958
80TCF3_18692474_ChIP-Seq_MESCs_Mouse1.46788542
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.46734687
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45350123
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45004339
84MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44719870
85EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.44689638
86TP53_22573176_ChIP-Seq_HFKS_Human1.42402632
87FOXP3_21729870_ChIP-Seq_TREG_Human1.42315682
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41637588
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41424316
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41316620
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41272650
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.40422690
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40380223
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.40147153
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39513673
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.38129711
97NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.36588881
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35540683
99FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34572814
100FOXA1_25329375_ChIP-Seq_VCAP_Human1.34572814
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32981736
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.32388281
103SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32052167
104HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31855581
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31436572
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31436572
107POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30767222
108E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29632517
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29437253
110NANOG_19829295_ChIP-Seq_ESCs_Human1.25691272
111SOX2_19829295_ChIP-Seq_ESCs_Human1.25691272
112TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25411438
113CRX_20693478_ChIP-Seq_RETINA_Mouse1.23811764
114* CDX2_22108803_ChIP-Seq_LS180_Human1.23701288
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.22661243
116FLI1_27457419_Chip-Seq_LIVER_Mouse1.22553349
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.21815227
118RUNX2_22187159_ChIP-Seq_PCA_Human1.20782323
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19621516
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17950455
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.17339693
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17309100
123* AR_20517297_ChIP-Seq_VCAP_Human1.15902300
124ELK1_19687146_ChIP-ChIP_HELA_Human1.15436082
125RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15290241
126EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13756289
127SMAD4_21741376_ChIP-Seq_EPCs_Human1.13440065
128NCOR_22424771_ChIP-Seq_293T_Human1.13397075
129GATA3_21878914_ChIP-Seq_MCF-7_Human1.13219369
130MYC_18940864_ChIP-ChIP_HL60_Human1.13172490
131DCP1A_22483619_ChIP-Seq_HELA_Human1.12726008
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12556238
133P53_22387025_ChIP-Seq_ESCs_Mouse1.12552902
134ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12108926
135PRDM14_20953172_ChIP-Seq_ESCs_Human1.09677957
136SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09464896
137* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08442852
138TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08418297
139FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07866147
140OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07785579
141ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07161660
142HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07107002
143YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06651334
144EGR1_19374776_ChIP-ChIP_THP-1_Human1.06236510
145RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05950653
146PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05803346
147SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05243234
148LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05030991
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04261674
150AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03217709
151STAT3_18555785_Chip-Seq_ESCs_Mouse1.02193710
152TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01827087
153FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01711400
154THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01341075
155PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01221049
156P300_18555785_Chip-Seq_ESCs_Mouse1.00662312
157TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00488525
158SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00446093
159KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00112591
160BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00045644
161FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96989994
162ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96050710
163ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95629198
164GABP_19822575_ChIP-Seq_HepG2_Human0.94060651
165AR_21909140_ChIP-Seq_LNCAP_Human0.91931496
166IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89649135
167SPI1_23547873_ChIP-Seq_NB4_Human0.89338729
168GATA1_26923725_Chip-Seq_HPCs_Mouse0.87669923
169KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85448487
170PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84659863
171SCL_19346495_ChIP-Seq_HPC-7_Human0.84062543
172POU5F1_16518401_ChIP-PET_MESCs_Mouse0.84026202
173E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83157288
174ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82943532
175* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.81339506
176SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81185926
177KDM5A_27292631_Chip-Seq_BREAST_Human0.80859431
178FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80521966
179CIITA_25753668_ChIP-Seq_RAJI_Human0.77879019
180ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77285953
181CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.76574359
182KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76469341
183POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.76461004
184TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.75873144
185NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.75530047
186NANOG_16153702_ChIP-ChIP_HESCs_Human0.73523949

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.61372067
2MP0006292_abnormal_olfactory_placode4.34453920
3MP0008057_abnormal_DNA_replication3.77002762
4MP0008995_early_reproductive_senescence3.38280653
5MP0003136_yellow_coat_color3.35707555
6MP0010094_abnormal_chromosome_stability3.33506512
7MP0003195_calcinosis3.31373598
8MP0003786_premature_aging3.17378667
9MP0002210_abnormal_sex_determination2.94353219
10MP0004957_abnormal_blastocyst_morpholog2.84057918
11MP0008058_abnormal_DNA_repair2.77097013
12MP0002837_dystrophic_cardiac_calcinosis2.71576819
13MP0005084_abnormal_gallbladder_morpholo2.53170993
14MP0003693_abnormal_embryo_hatching2.50562709
15MP0001968_abnormal_touch/_nociception2.50266216
16MP0004147_increased_porphyrin_level2.42601171
17MP0003077_abnormal_cell_cycle2.41969014
18MP0003111_abnormal_nucleus_morphology2.40996136
19MP0001145_abnormal_male_reproductive2.36965212
20MP0000569_abnormal_digit_pigmentation2.36426931
21MP0002736_abnormal_nociception_after2.35072796
22MP0001929_abnormal_gametogenesis2.31294614
23MP0004381_abnormal_hair_follicle2.27889784
24MP0002163_abnormal_gland_morphology2.25301178
25MP0005551_abnormal_eye_electrophysiolog2.22812150
26MP0005646_abnormal_pituitary_gland2.20791412
27MP0002928_abnormal_bile_duct2.19586570
28MP0003315_abnormal_perineum_morphology2.17105212
29MP0005075_abnormal_melanosome_morpholog2.16251207
30MP0005645_abnormal_hypothalamus_physiol2.15772310
31MP0008007_abnormal_cellular_replicative2.09023530
32MP0009379_abnormal_foot_pigmentation2.06840805
33MP0001188_hyperpigmentation2.06583683
34MP0000653_abnormal_sex_gland1.99951784
35MP0003123_paternal_imprinting1.97370747
36MP0001501_abnormal_sleep_pattern1.94474519
37MP0003011_delayed_dark_adaptation1.91165528
38MP0003698_abnormal_male_reproductive1.87829467
39MP0003646_muscle_fatigue1.86953858
40MP0008872_abnormal_physiological_respon1.86187799
41MP0002876_abnormal_thyroid_physiology1.80392417
42MP0000427_abnormal_hair_cycle1.76722256
43MP0009046_muscle_twitch1.76700406
44MP0009745_abnormal_behavioral_response1.72397503
45MP0008932_abnormal_embryonic_tissue1.69655788
46MP0002638_abnormal_pupillary_reflex1.69265306
47MP0006072_abnormal_retinal_apoptosis1.65870316
48MP0003121_genomic_imprinting1.62704966
49MP0001764_abnormal_homeostasis1.58588844
50MP0003890_abnormal_embryonic-extraembry1.57398940
51MP0005253_abnormal_eye_physiology1.56803777
52MP0000490_abnormal_crypts_of1.56446687
53MP0000631_abnormal_neuroendocrine_gland1.53972903
54MP0002277_abnormal_respiratory_mucosa1.53745407
55MP0003252_abnormal_bile_duct1.51730540
56MP0003787_abnormal_imprinting1.49139010
57MP0004043_abnormal_pH_regulation1.48738246
58MP0002138_abnormal_hepatobiliary_system1.48603959
59MP0005379_endocrine/exocrine_gland_phen1.47806260
60MP0003880_abnormal_central_pattern1.47250653
61MP0004742_abnormal_vestibular_system1.46836315
62MP0002938_white_spotting1.46055203
63MP0003941_abnormal_skin_development1.42491154
64MP0005174_abnormal_tail_pigmentation1.42435813
65MP0010386_abnormal_urinary_bladder1.41150341
66MP0002272_abnormal_nervous_system1.40845073
67MP0010352_gastrointestinal_tract_polyps1.37350982
68MP0001119_abnormal_female_reproductive1.36133570
69MP0000350_abnormal_cell_proliferation1.35867425
70MP0008875_abnormal_xenobiotic_pharmacok1.35277176
71MP0005409_darkened_coat_color1.34918055
72MP0002735_abnormal_chemical_nociception1.34071553
73MP0004142_abnormal_muscle_tone1.33970423
74MP0004133_heterotaxia1.33036715
75MP0002909_abnormal_adrenal_gland1.28516656
76MP0003938_abnormal_ear_development1.27867479
77MP0005310_abnormal_salivary_gland1.26533253
78MP0002254_reproductive_system_inflammat1.19699778
79MP0002160_abnormal_reproductive_system1.17791930
80MP0005085_abnormal_gallbladder_physiolo1.17187449
81MP0005332_abnormal_amino_acid1.15279361
82MP0005365_abnormal_bile_salt1.14552861
83MP0002733_abnormal_thermal_nociception1.14303959
84MP0001970_abnormal_pain_threshold1.13967535
85MP0005395_other_phenotype1.11517507
86MP0002693_abnormal_pancreas_physiology1.09845148
87MP0003763_abnormal_thymus_physiology1.08403019
88MP0001919_abnormal_reproductive_system1.08173727
89MP0002168_other_aberrant_phenotype1.07890737
90MP0002396_abnormal_hematopoietic_system1.06229386
91MP0002572_abnormal_emotion/affect_behav1.06002216
92MP0001293_anophthalmia1.03858048
93MP0000383_abnormal_hair_follicle1.03034803
94MP0001984_abnormal_olfaction1.02992460
95MP0000313_abnormal_cell_death1.02018605
96MP0002009_preneoplasia1.00627253
97MP0002019_abnormal_tumor_incidence1.00553865
98MP0005167_abnormal_blood-brain_barrier1.00048654
99MP0006276_abnormal_autonomic_nervous0.99270275
100MP0002161_abnormal_fertility/fecundity0.99225849
101MP0001835_abnormal_antigen_presentation0.98573922
102MP0002102_abnormal_ear_morphology0.98024036
103MP0003936_abnormal_reproductive_system0.97734959
104MP0005380_embryogenesis_phenotype0.96532009
105MP0001672_abnormal_embryogenesis/_devel0.96532009
106MP0002085_abnormal_embryonic_tissue0.96085457
107MP0002064_seizures0.95750915
108MP0005499_abnormal_olfactory_system0.95677732
109MP0005394_taste/olfaction_phenotype0.95677732
110MP0001986_abnormal_taste_sensitivity0.94593756
111MP0003718_maternal_effect0.93742944
112MP0001486_abnormal_startle_reflex0.92376665
113MP0000566_synostosis0.92151024
114MP0010368_abnormal_lymphatic_system0.90840509
115MP0005410_abnormal_fertilization0.90811390
116MP0004885_abnormal_endolymph0.89131098
117MP0002751_abnormal_autonomic_nervous0.88067217
118MP0010307_abnormal_tumor_latency0.87836796
119MP0004808_abnormal_hematopoietic_stem0.87569601
120MP0001756_abnormal_urination0.87340334
121MP0005257_abnormal_intraocular_pressure0.87173250
122MP0009333_abnormal_splenocyte_physiolog0.87163312
123MP0009780_abnormal_chondrocyte_physiolo0.85909281
124MP0000372_irregular_coat_pigmentation0.84731444
125MP0002557_abnormal_social/conspecific_i0.84144016
126MP0003635_abnormal_synaptic_transmissio0.83936774
127MP0005386_behavior/neurological_phenoty0.83226230
128MP0004924_abnormal_behavior0.83226230
129MP0002067_abnormal_sensory_capabilities0.83115310
130MP0008789_abnormal_olfactory_epithelium0.81485472
131MP0004215_abnormal_myocardial_fiber0.80802749
132MP0002234_abnormal_pharynx_morphology0.80149862
133MP0001905_abnormal_dopamine_level0.79686774
134MP0005171_absent_coat_pigmentation0.79506176
135MP0001485_abnormal_pinna_reflex0.79133399
136MP0005636_abnormal_mineral_homeostasis0.79033363
137MP0002075_abnormal_coat/hair_pigmentati0.78585039
138MP0010678_abnormal_skin_adnexa0.78539015
139MP0002095_abnormal_skin_pigmentation0.78020192
140MP0000049_abnormal_middle_ear0.77265809
141MP0005389_reproductive_system_phenotype0.76664709
142MP0002249_abnormal_larynx_morphology0.76237342
143MP0001730_embryonic_growth_arrest0.76170119
144MP0005195_abnormal_posterior_eye0.76144309
145MP0009785_altered_susceptibility_to0.75429186
146MP0000015_abnormal_ear_pigmentation0.75378379
147MP0002084_abnormal_developmental_patter0.75352653
148MP0003436_decreased_susceptibility_to0.75249569
149MP0005671_abnormal_response_to0.75142135
150MP0006082_CNS_inflammation0.74122773
151MP0003984_embryonic_growth_retardation0.73806732
152MP0004197_abnormal_fetal_growth/weight/0.73232190
153MP0003724_increased_susceptibility_to0.72361972
154MP0002088_abnormal_embryonic_growth/wei0.72232800
155MP0003937_abnormal_limbs/digits/tail_de0.72219425
156MP0002398_abnormal_bone_marrow0.71281881
157MP0001697_abnormal_embryo_size0.69285812
158MP0002653_abnormal_ependyma_morphology0.68472660
159MP0002148_abnormal_hypersensitivity_rea0.66832296
160MP0003699_abnormal_female_reproductive0.66643309
161MP0005000_abnormal_immune_tolerance0.65372638
162MP0005647_abnormal_sex_gland0.64738911
163MP0001186_pigmentation_phenotype0.64316358
164MP0000432_abnormal_head_morphology0.64065143
165MP0003448_altered_tumor_morphology0.63927644
166MP0002086_abnormal_extraembryonic_tissu0.63460439
167MP0002177_abnormal_outer_ear0.63353916
168MP0005248_abnormal_Harderian_gland0.62679695
169MP0002080_prenatal_lethality0.62492563
170MP0000858_altered_metastatic_potential0.62444127
171MP0000689_abnormal_spleen_morphology0.62224802
172MP0002722_abnormal_immune_system0.62204216
173MP0003755_abnormal_palate_morphology0.61721625

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.54658085
2Chromsome breakage (HP:0040012)5.43157659
3Azoospermia (HP:0000027)4.62931009
4Pancreatic cysts (HP:0001737)4.50988238
5Abnormal spermatogenesis (HP:0008669)4.14270394
6Pancreatic fibrosis (HP:0100732)3.93198687
7Supernumerary spleens (HP:0009799)3.89790948
8Meckel diverticulum (HP:0002245)3.80039332
9True hermaphroditism (HP:0010459)3.69532229
10Type II lissencephaly (HP:0007260)3.67676012
11Type I transferrin isoform profile (HP:0003642)3.57249077
12Abnormality of the ileum (HP:0001549)3.57066589
13Molar tooth sign on MRI (HP:0002419)3.55192342
14Abnormality of midbrain morphology (HP:0002418)3.55192342
15Abnormality of chromosome stability (HP:0003220)3.50659223
16Reticulocytopenia (HP:0001896)3.49245381
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.42527721
18Hypothermia (HP:0002045)3.34506876
19Abnormality of the preputium (HP:0100587)3.31092027
20Nephroblastoma (Wilms tumor) (HP:0002667)3.26910776
21Reduced antithrombin III activity (HP:0001976)3.24694435
22Abnormal lung lobation (HP:0002101)3.24470468
23Impulsivity (HP:0100710)3.19456528
24Congenital stationary night blindness (HP:0007642)3.16639766
25Polydipsia (HP:0001959)3.10629189
26Abnormal drinking behavior (HP:0030082)3.10629189
27Nephronophthisis (HP:0000090)3.09727920
28Rhabdomyosarcoma (HP:0002859)3.09101140
29Absent thumb (HP:0009777)3.06733388
30Ketoacidosis (HP:0001993)2.99883722
31Embryonal renal neoplasm (HP:0011794)2.99644832
32Tubular atrophy (HP:0000092)2.97315773
33Abnormality of the phalanges of the hallux (HP:0010057)2.94017732
34Bilateral microphthalmos (HP:0007633)2.92669204
35Abnormality of the renal cortex (HP:0011035)2.92359516
36Chronic hepatic failure (HP:0100626)2.90548079
37Increased corneal curvature (HP:0100692)2.89320084
38Keratoconus (HP:0000563)2.89320084
39Cystic liver disease (HP:0006706)2.87954434
40Medulloblastoma (HP:0002885)2.81900778
41Gonadotropin excess (HP:0000837)2.78981078
42Abnormality of the renal medulla (HP:0100957)2.78556688
43Rib fusion (HP:0000902)2.78250976
44Aplastic anemia (HP:0001915)2.69268403
45Bile duct proliferation (HP:0001408)2.69029964
46Abnormal biliary tract physiology (HP:0012439)2.69029964
47Abnormality of cells of the erythroid lineage (HP:0012130)2.68705450
48Small intestinal stenosis (HP:0012848)2.67275158
49Duodenal stenosis (HP:0100867)2.67275158
50Triphalangeal thumb (HP:0001199)2.67229283
51Horizontal nystagmus (HP:0000666)2.60252578
52Abnormal sex determination (HP:0012244)2.59800271
53Sex reversal (HP:0012245)2.59800271
54Abnormal rod and cone electroretinograms (HP:0008323)2.56868491
55Ependymoma (HP:0002888)2.55839110
56Hypomagnesemia (HP:0002917)2.54756141
57Abnormal number of erythroid precursors (HP:0012131)2.53927394
58Clubbing of toes (HP:0100760)2.53433952
59Neoplasm of striated muscle (HP:0009728)2.52112796
60Methylmalonic acidemia (HP:0002912)2.51511298
61Sclerocornea (HP:0000647)2.51384302
62Hyperglycinuria (HP:0003108)2.50955505
6311 pairs of ribs (HP:0000878)2.50623602
64Ketosis (HP:0001946)2.49967698
65Decreased circulating renin level (HP:0003351)2.47994534
66Abolished electroretinogram (ERG) (HP:0000550)2.47187940
67Dialeptic seizures (HP:0011146)2.44403653
68Cerebellar dysplasia (HP:0007033)2.44051901
69Microvesicular hepatic steatosis (HP:0001414)2.42692710
70Hypoplasia of the fovea (HP:0007750)2.41789165
71Aplasia/Hypoplasia of the fovea (HP:0008060)2.41789165
72Progressive external ophthalmoplegia (HP:0000590)2.39384436
73Progressive inability to walk (HP:0002505)2.39168740
74Methylmalonic aciduria (HP:0012120)2.38111979
75Aplasia/Hypoplasia of the tongue (HP:0010295)2.36308959
76Ectopic kidney (HP:0000086)2.34828332
77Hypoplasia of the pons (HP:0012110)2.34154877
78Myelodysplasia (HP:0002863)2.33953869
79Polyuria (HP:0000103)2.33888949
80Aplasia/Hypoplasia of the sacrum (HP:0008517)2.33585702
81Male pseudohermaphroditism (HP:0000037)2.31804440
823-Methylglutaconic aciduria (HP:0003535)2.31087138
83Febrile seizures (HP:0002373)2.29491035
84Gaze-evoked nystagmus (HP:0000640)2.28629277
85Hyperventilation (HP:0002883)2.27807853
86Attenuation of retinal blood vessels (HP:0007843)2.27456984
87Premature ovarian failure (HP:0008209)2.27435277
88Medial flaring of the eyebrow (HP:0010747)2.26496278
89Bone marrow hypocellularity (HP:0005528)2.23788966
90Pallor (HP:0000980)2.22641852
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22523203
92Cleft eyelid (HP:0000625)2.22031659
93Focal motor seizures (HP:0011153)2.21608231
94Hypokalemic alkalosis (HP:0001949)2.21294450
95Rectovaginal fistula (HP:0000143)2.21007992
96Rectal fistula (HP:0100590)2.21007992
97Testicular atrophy (HP:0000029)2.19907293
98Abnormality of the pons (HP:0007361)2.19772726
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19104243
100Pendular nystagmus (HP:0012043)2.19104233
101Abnormality of the duodenum (HP:0002246)2.18524601
102Decreased central vision (HP:0007663)2.17326387
103Capillary hemangiomas (HP:0005306)2.16770781
104Agnosia (HP:0010524)2.14404562
105Absent radius (HP:0003974)2.14106338
106Intestinal fistula (HP:0100819)2.13279650
107Parakeratosis (HP:0001036)2.11663011
108Tracheoesophageal fistula (HP:0002575)2.11110083
109Lissencephaly (HP:0001339)2.10403803
110Anencephaly (HP:0002323)2.08840260
111Sloping forehead (HP:0000340)2.04795404
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01619577
113Abnormality of serine family amino acid metabolism (HP:0010894)2.01342209
114Abnormality of glycine metabolism (HP:0010895)2.01342209
115Duplicated collecting system (HP:0000081)2.01227917
116Chronic bronchitis (HP:0004469)2.01181567
117Aplasia/Hypoplasia of the tibia (HP:0005772)2.00891400
118Aplasia involving forearm bones (HP:0009822)2.00003796
119Absent forearm bone (HP:0003953)2.00003796
120Aplasia/hypoplasia of the uterus (HP:0008684)1.98404159
121Hypoplasia of the radius (HP:0002984)1.96421687
122Furrowed tongue (HP:0000221)1.96413933
123Chorioretinal atrophy (HP:0000533)1.95294141
124Abnormal protein glycosylation (HP:0012346)1.94800392
125Abnormal glycosylation (HP:0012345)1.94800392
126Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94800392
127Abnormal protein N-linked glycosylation (HP:0012347)1.94800392
128Intestinal atresia (HP:0011100)1.94683404
129Congenital hepatic fibrosis (HP:0002612)1.94545048
130Inability to walk (HP:0002540)1.94236143
131Abnormality of the carotid arteries (HP:0005344)1.92770666
132Severe visual impairment (HP:0001141)1.92037816
133Duplication of thumb phalanx (HP:0009942)1.91571454
134Macrocytic anemia (HP:0001972)1.91242624
135Broad-based gait (HP:0002136)1.90838324
136Volvulus (HP:0002580)1.90577581
137Supernumerary ribs (HP:0005815)1.89578889
138Tetany (HP:0001281)1.87554421
139Supernumerary bones of the axial skeleton (HP:0009144)1.86654181
140Shawl scrotum (HP:0000049)1.84687858
141Abnormality of the lower motor neuron (HP:0002366)1.84001777
142Large for gestational age (HP:0001520)1.83192460
143Abnormal urine output (HP:0012590)1.82764040
144Focal seizures (HP:0007359)1.82571344
145Dynein arm defect of respiratory motile cilia (HP:0012255)1.81729892
146Absent/shortened dynein arms (HP:0200106)1.81729892
147Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81013204
148Colon cancer (HP:0003003)1.80038940
149Hypoalbuminemia (HP:0003073)1.79968799
150Abnormal albumin level (HP:0012116)1.79968799
151Stomach cancer (HP:0012126)1.79248828
152Aplasia/Hypoplasia involving the musculature (HP:0001460)1.77893524
153Postaxial foot polydactyly (HP:0001830)1.77425153
154Anomalous pulmonary venous return (HP:0010772)1.77259565
155Facial cleft (HP:0002006)1.76896389
156Missing ribs (HP:0000921)1.76725240
157Abnormality of macular pigmentation (HP:0008002)1.76632823
158Facial hemangioma (HP:0000329)1.76391452
159Abnormality of vitamin B metabolism (HP:0004340)1.75750338
160Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75725110
161Tongue fasciculations (HP:0001308)1.75581380
162Bony spicule pigmentary retinopathy (HP:0007737)1.74406017
163Carpal bone hypoplasia (HP:0001498)1.73525569
164Absence seizures (HP:0002121)1.73146366
165Short thumb (HP:0009778)1.72875209
166Trismus (HP:0000211)1.72676553
167Astigmatism (HP:0000483)1.72471400
168Atonic seizures (HP:0010819)1.71312398
169Abnormality of DNA repair (HP:0003254)1.70898750
170Abnormality of the renal collecting system (HP:0004742)1.70803244
171Abnormality of magnesium homeostasis (HP:0004921)1.70483982
172Renal cortical cysts (HP:0000803)1.69881803
173Abnormality of alanine metabolism (HP:0010916)1.69763001
174Hyperalaninemia (HP:0003348)1.69763001
175Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69763001
176Dyskinesia (HP:0100660)1.69700956
177Secondary amenorrhea (HP:0000869)1.69549855
178Impaired proprioception (HP:0010831)1.69266774
179Abnormality of the salivary glands (HP:0010286)1.68904170
180Lip pit (HP:0100267)1.68667280
181Aplasia/hypoplasia of the humerus (HP:0006507)1.68507429
182Abnormality of the fovea (HP:0000493)1.68410686
183Progressive cerebellar ataxia (HP:0002073)1.67332372
184Septo-optic dysplasia (HP:0100842)1.67267960
185Pachygyria (HP:0001302)1.66631761
186Abnormality of the pulmonary veins (HP:0011718)1.66589636
187Occipital encephalocele (HP:0002085)1.66575164
188Abnormal respiratory motile cilium morphology (HP:0005938)1.65878388
189Abnormal respiratory epithelium morphology (HP:0012253)1.65878388
190Adactyly (HP:0009776)1.65497944
191Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65130438
192Dandy-Walker malformation (HP:0001305)1.64879255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.34425825
2FRK6.99514209
3ACVR1B3.88511408
4CDC73.43926556
5MKNK23.39827530
6TLK13.10068907
7MAP4K22.69404505
8SRPK12.63166716
9WEE12.52428194
10TNIK2.42581828
11INSRR2.25686006
12STK38L2.15701762
13MKNK12.12494515
14MUSK2.07484418
15WNK32.05761257
16TTK2.03307242
17NME22.01853376
18TIE12.01163691
19CDK71.94367338
20NLK1.88997892
21NUAK11.87583712
22BRD41.84101656
23GRK51.78140298
24EPHA41.66442993
25NEK21.64179345
26PLK11.61084400
27CASK1.59753397
28WNK41.56908400
29STK391.54309424
30EIF2AK31.54308425
31ADRBK21.50287703
32TRIM281.47826250
33GRK11.41874434
34EIF2AK11.40147332
35DAPK21.37430209
36PAK31.35532780
37MATK1.34367941
38OXSR11.32756429
39CHEK21.31987051
40FGFR21.28442268
41PLK41.27628361
42STK31.18856790
43CLK11.16325382
44BCR1.16027953
45PRKD21.14717007
46MAP3K41.09954341
47IRAK41.09921017
48MARK11.09074521
49CSF1R1.08893369
50TAOK31.06266201
51ATR1.05922755
52CDK41.05456260
53MAPKAPK31.04324823
54VRK11.04202166
55ERBB31.03810055
56EIF2AK21.02703046
57CAMKK21.02418798
58DYRK30.99470476
59PRKCE0.99344159
60CHEK10.97529428
61CDK90.97494379
62AURKB0.97478947
63GRK70.97410749
64PBK0.97052974
65LATS10.96977413
66STK160.94700934
67IRAK30.94207182
68PHKG10.92998847
69PHKG20.92998847
70ATM0.92923875
71PDK20.90749168
72CDK80.90148902
73PKN10.89684618
74TGFBR10.86965670
75MAP3K120.85806660
76MAP2K70.84910695
77BLK0.83634156
78GRK60.83227548
79ADRBK10.82678827
80BUB10.81400838
81BRSK20.80815053
82TEC0.79493194
83TXK0.77105492
84MAP3K90.75533820
85YES10.75125839
86STK40.74265578
87PINK10.72812446
88PIM10.72704895
89PRKCG0.72570666
90MAPK70.71427294
91PLK20.71382577
92IRAK10.70410295
93CSNK1G10.70147512
94MST40.68089609
95PIK3CG0.67159786
96CSNK1G30.66815325
97CDK20.65181989
98ERN10.64875293
99PRKCQ0.63731297
100CAMK40.63411279
101PRPF4B0.63073537
102TGFBR20.61312028
103PLK30.60962759
104FLT30.60005541
105PNCK0.58811301
106CSNK1G20.56653961
107STK100.55353338
108VRK20.53943128
109AURKA0.53696906
110RPS6KB20.52553526
111EPHA20.52142627
112WNK10.51994329
113NME10.51262993
114CSK0.50741693
115CDK10.50474620
116IKBKB0.50198114
117PRKAA20.49717846
118CSNK2A20.49008820
119CHUK0.47911027
120BCKDK0.47043758
121CAMK2A0.46834118
122CSNK1A10.46043449
123MARK30.45773795
124DYRK1A0.43027980
125PRKG20.42515125
126MAP2K10.42187266
127CSNK2A10.41887301
128PRKD30.41870134
129MOS0.41860034
130STK240.41383897
131KIT0.41010201
132RPS6KA50.39406354
133MAP3K60.38052320
134AKT30.37896768
135MAPK150.37626028
136CDK30.36501859
137PRKACA0.36380292
138DYRK20.36189988
139ZAK0.36019232
140TYRO30.36013815
141FER0.35981833
142PTK2B0.35928649
143TNK20.34271923
144MINK10.34043542
145PRKG10.33810874
146PRKCZ0.33257101
147ABL10.32373666
148STK380.32003872
149PIK3CA0.31835797
150CSNK1D0.31718936
151IRAK20.31639659
152MELK0.30522637
153BMPR1B0.30410235
154STK110.30251183
155MAPK130.30083921
156GSK3B0.30002825
157PIM20.29917968
158CAMK10.29524075
159ITK0.29021689
160MAPK140.28985229
161PRKCI0.28756367
162NEK10.28435330
163LCK0.27470520
164MAP2K60.26179428
165FES0.26070236
166ABL20.25687911

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.18133835
2Ribosome_Homo sapiens_hsa030103.77274354
3DNA replication_Homo sapiens_hsa030303.68382023
4Homologous recombination_Homo sapiens_hsa034403.57361598
5Basal transcription factors_Homo sapiens_hsa030223.35760265
6Butanoate metabolism_Homo sapiens_hsa006503.14990560
7Mismatch repair_Homo sapiens_hsa034303.10980763
8Fanconi anemia pathway_Homo sapiens_hsa034603.06927036
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.03749305
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.02416939
11RNA polymerase_Homo sapiens_hsa030202.83807651
12Spliceosome_Homo sapiens_hsa030402.59607467
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.45590687
14RNA transport_Homo sapiens_hsa030132.39128922
15Nucleotide excision repair_Homo sapiens_hsa034202.38988132
16Nitrogen metabolism_Homo sapiens_hsa009102.22797813
17Tryptophan metabolism_Homo sapiens_hsa003802.14160712
18Propanoate metabolism_Homo sapiens_hsa006402.12576307
19Cell cycle_Homo sapiens_hsa041102.12194764
20Base excision repair_Homo sapiens_hsa034102.07906792
21Non-homologous end-joining_Homo sapiens_hsa034502.00974158
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99929808
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90995914
24Pyrimidine metabolism_Homo sapiens_hsa002401.77603247
25RNA degradation_Homo sapiens_hsa030181.72860947
26mRNA surveillance pathway_Homo sapiens_hsa030151.72718568
27Selenocompound metabolism_Homo sapiens_hsa004501.71712078
28Thyroid cancer_Homo sapiens_hsa052161.71260856
29Regulation of autophagy_Homo sapiens_hsa041401.68470149
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67700262
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67422770
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.67382546
33One carbon pool by folate_Homo sapiens_hsa006701.64024356
34Proteasome_Homo sapiens_hsa030501.56510348
35Olfactory transduction_Homo sapiens_hsa047401.55973049
36Herpes simplex infection_Homo sapiens_hsa051681.53250190
37p53 signaling pathway_Homo sapiens_hsa041151.41686970
38Taste transduction_Homo sapiens_hsa047421.40803953
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37368798
40Arachidonic acid metabolism_Homo sapiens_hsa005901.36922663
41Nicotine addiction_Homo sapiens_hsa050331.36609204
42Graft-versus-host disease_Homo sapiens_hsa053321.31893537
43Caffeine metabolism_Homo sapiens_hsa002321.25461699
44Linoleic acid metabolism_Homo sapiens_hsa005911.20572635
45Collecting duct acid secretion_Homo sapiens_hsa049661.17317453
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13176093
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12371347
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09266863
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09249256
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.08222691
51Peroxisome_Homo sapiens_hsa041461.01990035
52Purine metabolism_Homo sapiens_hsa002301.01916958
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00776720
54Fatty acid degradation_Homo sapiens_hsa000711.00086337
55Morphine addiction_Homo sapiens_hsa050320.99625734
56Insulin secretion_Homo sapiens_hsa049110.97170842
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96875227
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.93846185
59Sulfur metabolism_Homo sapiens_hsa009200.92624715
60Allograft rejection_Homo sapiens_hsa053300.92002325
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89798044
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87313403
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87168530
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.87064609
65Serotonergic synapse_Homo sapiens_hsa047260.86089082
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83505085
67Antigen processing and presentation_Homo sapiens_hsa046120.82110869
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81934604
69Ovarian steroidogenesis_Homo sapiens_hsa049130.81898681
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81693823
71Systemic lupus erythematosus_Homo sapiens_hsa053220.80876971
72Primary immunodeficiency_Homo sapiens_hsa053400.79832866
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78903513
74Steroid biosynthesis_Homo sapiens_hsa001000.76549613
75Influenza A_Homo sapiens_hsa051640.76384590
76beta-Alanine metabolism_Homo sapiens_hsa004100.75694479
77Retinol metabolism_Homo sapiens_hsa008300.75050707
78Epstein-Barr virus infection_Homo sapiens_hsa051690.74304282
79Asthma_Homo sapiens_hsa053100.74097130
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72180171
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71735757
82Glutamatergic synapse_Homo sapiens_hsa047240.71487874
83Hematopoietic cell lineage_Homo sapiens_hsa046400.70877675
84Huntingtons disease_Homo sapiens_hsa050160.70824064
85Salivary secretion_Homo sapiens_hsa049700.69801164
86Leishmaniasis_Homo sapiens_hsa051400.69147927
87Ether lipid metabolism_Homo sapiens_hsa005650.68273965
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68066802
89Fatty acid metabolism_Homo sapiens_hsa012120.68021725
90Measles_Homo sapiens_hsa051620.67862978
91Notch signaling pathway_Homo sapiens_hsa043300.66258123
92ABC transporters_Homo sapiens_hsa020100.65652477
93Basal cell carcinoma_Homo sapiens_hsa052170.65002975
94Fatty acid biosynthesis_Homo sapiens_hsa000610.64961259
95Chemical carcinogenesis_Homo sapiens_hsa052040.63371924
96Circadian entrainment_Homo sapiens_hsa047130.63208542
97Metabolic pathways_Homo sapiens_hsa011000.63084363
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62475113
99Dopaminergic synapse_Homo sapiens_hsa047280.61536101
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60775767
101HTLV-I infection_Homo sapiens_hsa051660.60296558
102Sulfur relay system_Homo sapiens_hsa041220.60203149
103GABAergic synapse_Homo sapiens_hsa047270.58564689
104Calcium signaling pathway_Homo sapiens_hsa040200.58472866
105Fat digestion and absorption_Homo sapiens_hsa049750.58193747
106Other glycan degradation_Homo sapiens_hsa005110.58000763
107Long-term depression_Homo sapiens_hsa047300.57048451
108Lysine degradation_Homo sapiens_hsa003100.56417351
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.55702243
110MicroRNAs in cancer_Homo sapiens_hsa052060.54878716
111Glycerolipid metabolism_Homo sapiens_hsa005610.54737745
112Amphetamine addiction_Homo sapiens_hsa050310.54036023
113Protein export_Homo sapiens_hsa030600.53158464
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.53046039
115Oocyte meiosis_Homo sapiens_hsa041140.53016165
116Viral carcinogenesis_Homo sapiens_hsa052030.51921768
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.50956986
118Autoimmune thyroid disease_Homo sapiens_hsa053200.50688942
119Circadian rhythm_Homo sapiens_hsa047100.49932617
120Cocaine addiction_Homo sapiens_hsa050300.49322065
121Alzheimers disease_Homo sapiens_hsa050100.48999151
122Wnt signaling pathway_Homo sapiens_hsa043100.48838464
123Folate biosynthesis_Homo sapiens_hsa007900.46619684
124Histidine metabolism_Homo sapiens_hsa003400.45844557
125Pyruvate metabolism_Homo sapiens_hsa006200.43999541
126Acute myeloid leukemia_Homo sapiens_hsa052210.43405438
127Pathways in cancer_Homo sapiens_hsa052000.41374490
128Vitamin B6 metabolism_Homo sapiens_hsa007500.40725561
129Mineral absorption_Homo sapiens_hsa049780.39613757
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39232449
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38688873
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.37960106
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37504512
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37447367
135Rheumatoid arthritis_Homo sapiens_hsa053230.37381242
136Malaria_Homo sapiens_hsa051440.37239476
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37113938
138Dorso-ventral axis formation_Homo sapiens_hsa043200.37008526
139Pentose phosphate pathway_Homo sapiens_hsa000300.36940338
140Cardiac muscle contraction_Homo sapiens_hsa042600.36478003
141Salmonella infection_Homo sapiens_hsa051320.35031525
142TGF-beta signaling pathway_Homo sapiens_hsa043500.34600536
143Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34416647
144Sphingolipid metabolism_Homo sapiens_hsa006000.33502780
145Legionellosis_Homo sapiens_hsa051340.33332714
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32942873
147African trypanosomiasis_Homo sapiens_hsa051430.30288033
148Apoptosis_Homo sapiens_hsa042100.30181366
149Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27747608
150Alcoholism_Homo sapiens_hsa050340.27465286
151Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26907485
152Type I diabetes mellitus_Homo sapiens_hsa049400.25996765
153Oxidative phosphorylation_Homo sapiens_hsa001900.25635462
154Phototransduction_Homo sapiens_hsa047440.25623870
155Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24770400
156Hepatitis B_Homo sapiens_hsa051610.24144421
157Tuberculosis_Homo sapiens_hsa051520.22583453
158Small cell lung cancer_Homo sapiens_hsa052220.22252556
159Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21315655
160Colorectal cancer_Homo sapiens_hsa052100.20943357
161Parkinsons disease_Homo sapiens_hsa050120.19020992
162Pertussis_Homo sapiens_hsa051330.18452675
163TNF signaling pathway_Homo sapiens_hsa046680.18062669
164T cell receptor signaling pathway_Homo sapiens_hsa046600.18003782
165Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17797742
166Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.17789618

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