USP27X

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase protein family. The encoded protein functions as a deubiquitinase that is involved in upregulation of the pro-apoptotic Bim protein. This protein may act as a tumor suppressor by increasing levels of Bim to counteract anti-apoptotic signals in cancer cells. Mutations in this gene have been associated with X-linked mental retardation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)5.73821683
2doxorubicin metabolic process (GO:0044598)5.73821683
3daunorubicin metabolic process (GO:0044597)5.73821683
4behavioral response to nicotine (GO:0035095)5.03779413
5presynaptic membrane assembly (GO:0097105)4.91616854
6postsynaptic membrane organization (GO:0001941)4.91249827
7presynaptic membrane organization (GO:0097090)4.42940248
8neuron cell-cell adhesion (GO:0007158)4.37429062
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.31806522
10sulfation (GO:0051923)4.28590576
11vocalization behavior (GO:0071625)4.25562858
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.05800871
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.91846710
14regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.76327064
15gamma-aminobutyric acid transport (GO:0015812)3.76161107
16cell proliferation in forebrain (GO:0021846)3.75777153
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.73889685
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.73241965
19protein localization to synapse (GO:0035418)3.59957063
20regulation of glutamate receptor signaling pathway (GO:1900449)3.54148044
21histone H4-K12 acetylation (GO:0043983)3.48625987
22otic vesicle formation (GO:0030916)3.45832520
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38022646
24mitochondrial respiratory chain complex I assembly (GO:0032981)3.38022646
25NADH dehydrogenase complex assembly (GO:0010257)3.38022646
26central nervous system projection neuron axonogenesis (GO:0021952)3.34423222
27primary amino compound metabolic process (GO:1901160)3.31353381
28protein complex biogenesis (GO:0070271)3.27997266
29positive regulation of synaptic transmission, GABAergic (GO:0032230)3.25727259
30glutamate receptor signaling pathway (GO:0007215)3.24908093
31pyrimidine nucleobase catabolic process (GO:0006208)3.24011229
32regulation of respiratory system process (GO:0044065)3.23118800
33aminoglycoside antibiotic metabolic process (GO:0030647)3.22683600
34proline transport (GO:0015824)3.22337404
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.21673881
36negative regulation of synaptic transmission, GABAergic (GO:0032229)3.21533310
37synaptic vesicle endocytosis (GO:0048488)3.19925172
38regulation of glomerulus development (GO:0090192)3.19514905
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.19178949
40synaptic vesicle docking involved in exocytosis (GO:0016081)3.17910764
41somite development (GO:0061053)3.14678966
42synaptic transmission, glutamatergic (GO:0035249)3.12961896
43protein polyglutamylation (GO:0018095)3.11197904
44dentate gyrus development (GO:0021542)3.08859294
45locomotory exploration behavior (GO:0035641)3.07236498
46auditory behavior (GO:0031223)3.03077542
47limb bud formation (GO:0060174)3.02871730
48exploration behavior (GO:0035640)3.02736948
49response to pheromone (GO:0019236)3.01517345
50dendritic spine morphogenesis (GO:0060997)2.98847220
51neurotransmitter-gated ion channel clustering (GO:0072578)2.97690981
52dopaminergic neuron differentiation (GO:0071542)2.97654990
53glycerophospholipid catabolic process (GO:0046475)2.97625025
54water-soluble vitamin biosynthetic process (GO:0042364)2.97358183
55negative regulation of response to food (GO:0032096)2.95015560
56negative regulation of appetite (GO:0032099)2.95015560
57response to histamine (GO:0034776)2.93585486
58cellular response to ATP (GO:0071318)2.93391911
59positive regulation of synapse assembly (GO:0051965)2.92606117
60mitochondrial respiratory chain complex assembly (GO:0033108)2.92519501
61neurofilament cytoskeleton organization (GO:0060052)2.92015850
62regulation of action potential (GO:0098900)2.90946500
63mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.90724839
64mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.89813255
65synaptic vesicle maturation (GO:0016188)2.89214308
66neuron recognition (GO:0008038)2.88933798
67pharyngeal system development (GO:0060037)2.87842269
68positive regulation of cAMP-mediated signaling (GO:0043950)2.86212373
69neuronal action potential (GO:0019228)2.85233494
70regulation of excitatory postsynaptic membrane potential (GO:0060079)2.84605699
71regulation of synaptic vesicle exocytosis (GO:2000300)2.84250281
72positive regulation of neurotransmitter secretion (GO:0001956)2.83779451
73startle response (GO:0001964)2.82293837
74regulation of respiratory gaseous exchange (GO:0043576)2.81703057
75membrane depolarization during action potential (GO:0086010)2.81496480
76mechanosensory behavior (GO:0007638)2.81256832
77positive regulation of male gonad development (GO:2000020)2.81154070
78synaptic vesicle exocytosis (GO:0016079)2.80987346
79central nervous system neuron axonogenesis (GO:0021955)2.80649573
80axonal fasciculation (GO:0007413)2.79548128
81protein neddylation (GO:0045116)2.78547344
82cerebral cortex radially oriented cell migration (GO:0021799)2.77987057
83epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.77509825
84regulation of male gonad development (GO:2000018)2.76750867
85regulation of postsynaptic membrane potential (GO:0060078)2.76093889
86negative regulation of systemic arterial blood pressure (GO:0003085)2.75568014
87nucleobase catabolic process (GO:0046113)2.73530528
88energy coupled proton transport, down electrochemical gradient (GO:0015985)2.72108001
89ATP synthesis coupled proton transport (GO:0015986)2.72108001
90adaptation of signaling pathway (GO:0023058)2.69475735
91spinal cord motor neuron differentiation (GO:0021522)2.68902334
92purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.66835006
933-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.66835006
94DNA strand renaturation (GO:0000733)2.66746929
95replication fork processing (GO:0031297)2.66706890
96positive regulation of potassium ion transmembrane transport (GO:1901381)2.65716319
97gamma-aminobutyric acid signaling pathway (GO:0007214)2.65474890
98parturition (GO:0007567)2.64609217
99positive regulation of meiosis (GO:0045836)2.63458542
100neuron-neuron synaptic transmission (GO:0007270)2.62953359
101facial nerve structural organization (GO:0021612)2.62698513
102regulation of long-term neuronal synaptic plasticity (GO:0048169)2.61653354
103regulation of synaptic transmission, GABAergic (GO:0032228)2.61405521
104indole-containing compound metabolic process (GO:0042430)2.60851994
105regulation of cell proliferation involved in kidney development (GO:1901722)2.60824926
106righting reflex (GO:0060013)2.60794543
107regulation of collateral sprouting (GO:0048670)2.60611907
108behavioral fear response (GO:0001662)2.58889078
109behavioral defense response (GO:0002209)2.58889078
110dendritic spine organization (GO:0097061)2.56720575
111regulation of neuronal synaptic plasticity (GO:0048168)2.56680223
112prostate gland growth (GO:0060736)2.56360614
113negative regulation of transcription regulatory region DNA binding (GO:2000678)2.56266391
114regulation of dopamine secretion (GO:0014059)2.55823111
115G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.55702370
116negative regulation of astrocyte differentiation (GO:0048712)2.53917920
117response to auditory stimulus (GO:0010996)2.53025358
118detection of light stimulus involved in visual perception (GO:0050908)2.52542632
119detection of light stimulus involved in sensory perception (GO:0050962)2.52542632
120cell migration in hindbrain (GO:0021535)2.50997367
121regulation of synapse assembly (GO:0051963)2.50384771
122positive regulation of dendritic spine morphogenesis (GO:0061003)2.49520090
123regulation of synaptic vesicle transport (GO:1902803)2.49278275
124long-term memory (GO:0007616)2.48915149
125indolalkylamine metabolic process (GO:0006586)2.44990349
126negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.44487093
127regulation of calcium ion-dependent exocytosis (GO:0017158)2.43673908
128lateral ventricle development (GO:0021670)2.43618433
129regulation of pigment cell differentiation (GO:0050932)2.43233177
130neuromuscular process controlling posture (GO:0050884)2.43181093
131regulation of cAMP-dependent protein kinase activity (GO:2000479)2.42957295
132negative regulation of translation, ncRNA-mediated (GO:0040033)2.42198834
133regulation of translation, ncRNA-mediated (GO:0045974)2.42198834
134negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.42198834
135generation of neurons (GO:0048699)2.42066666
136regulation of feeding behavior (GO:0060259)2.41174352
137magnesium ion transport (GO:0015693)2.40889583
138positive regulation of meiotic cell cycle (GO:0051446)2.39969052
139synapse assembly (GO:0007416)2.39902011
140thalamus development (GO:0021794)2.39823374
141action potential (GO:0001508)2.39390163
142regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.39104198
143serotonin receptor signaling pathway (GO:0007210)2.38995476
144opioid receptor signaling pathway (GO:0038003)2.38888740
145transmission of nerve impulse (GO:0019226)2.37946988
146cell differentiation in hindbrain (GO:0021533)2.37670326
147endocrine pancreas development (GO:0031018)2.37322084
148glutamate secretion (GO:0014047)2.37057342
149membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.36952607
150DNA deamination (GO:0045006)2.35683277
151dendrite development (GO:0016358)2.35679689
152positive regulation of neurotransmitter transport (GO:0051590)2.35377725
153innervation (GO:0060384)2.34805920
154pituitary gland development (GO:0021983)2.34789367
155reflex (GO:0060004)2.34627508
156positive regulation of dendritic spine development (GO:0060999)2.34423302
157positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.34261267
158fear response (GO:0042596)2.33935091
159positive regulation of membrane potential (GO:0045838)2.32780856
160epithelial cell fate commitment (GO:0072148)2.32387618
161neuron maturation (GO:0042551)2.31952268
162behavioral response to ethanol (GO:0048149)2.31604287
163regulation of type B pancreatic cell apoptotic process (GO:2000674)2.31249824
164positive regulation of cardiac muscle cell differentiation (GO:2000727)2.31222247
165mRNA splice site selection (GO:0006376)2.31013362
166regulation of synaptic transmission, glutamatergic (GO:0051966)2.30539803
167synaptic transmission, cholinergic (GO:0007271)2.30531767
168dopamine transport (GO:0015872)2.30101210
169cranial nerve structural organization (GO:0021604)2.29544598
170indole-containing compound catabolic process (GO:0042436)2.28213819
171indolalkylamine catabolic process (GO:0046218)2.28213819
172tryptophan catabolic process (GO:0006569)2.28213819
173maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.27685480
174auditory receptor cell stereocilium organization (GO:0060088)2.27013426
175positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.26711574
176epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.26327336
177dendrite morphogenesis (GO:0048813)2.25042934
178learning (GO:0007612)2.21713327
179mitotic sister chromatid cohesion (GO:0007064)2.20697921
180serotonin metabolic process (GO:0042428)2.20406532
181positive regulation of developmental pigmentation (GO:0048087)2.18969354
182layer formation in cerebral cortex (GO:0021819)2.18803598
183histone arginine methylation (GO:0034969)2.18332996

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.46332450
2GBX2_23144817_ChIP-Seq_PC3_Human3.57688332
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.91862147
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62026082
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33833946
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.33072086
7ZNF274_21170338_ChIP-Seq_K562_Hela2.28780208
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.28373329
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.27566061
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19206692
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15656672
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.14182852
13RNF2_27304074_Chip-Seq_NSC_Mouse2.14144631
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10975902
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10975902
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10965055
17REST_21632747_ChIP-Seq_MESCs_Mouse2.10853296
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10445211
19IGF1R_20145208_ChIP-Seq_DFB_Human2.05133096
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04244926
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03035634
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01248714
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.98738783
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96161556
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.89124812
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.81275325
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80604142
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75136612
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75004613
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.69487168
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67394821
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66733297
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65196522
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.63639701
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.60905862
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60362911
37RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.59704164
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57896360
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56556354
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56059584
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55754371
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.55672614
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.55672614
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.55672614
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52214966
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50688031
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50109125
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49460287
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.48653333
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48619526
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47988825
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.46369980
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43995489
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42748687
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42605193
56P300_19829295_ChIP-Seq_ESCs_Human1.42220912
57FUS_26573619_Chip-Seq_HEK293_Human1.41649508
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.41237342
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40608827
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40587305
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39964779
62SMAD4_21799915_ChIP-Seq_A2780_Human1.38434433
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.37769439
64BCAT_22108803_ChIP-Seq_LS180_Human1.37582499
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34817276
66VDR_22108803_ChIP-Seq_LS180_Human1.34635911
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.33888984
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.33458006
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33065016
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32110908
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32042181
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31860156
73ER_23166858_ChIP-Seq_MCF-7_Human1.30713023
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30291101
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29355546
76EWS_26573619_Chip-Seq_HEK293_Human1.28099634
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26807196
78IRF1_19129219_ChIP-ChIP_H3396_Human1.26761376
79TAF15_26573619_Chip-Seq_HEK293_Human1.26550791
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26022205
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25813369
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24980872
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24083824
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24083824
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22888577
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20223725
87CBP_20019798_ChIP-Seq_JUKART_Human1.20223725
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.19945524
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.18976748
90STAT3_23295773_ChIP-Seq_U87_Human1.18234105
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17900910
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17322880
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17304568
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.16499555
95AR_21572438_ChIP-Seq_LNCaP_Human1.14895350
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14711892
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13272584
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13001486
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12656414
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.12133036
101KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11578541
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.11032615
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10423497
104SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09294153
105DROSHA_22980978_ChIP-Seq_HELA_Human1.07893890
106TAL1_26923725_Chip-Seq_HPCs_Mouse1.07733471
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07706803
108P53_22387025_ChIP-Seq_ESCs_Mouse1.07437523
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06081279
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.05999872
111P300_18555785_Chip-Seq_ESCs_Mouse1.05855561
112ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05799963
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.05444487
114STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04964106
115RUNX2_22187159_ChIP-Seq_PCA_Human1.04823857
116SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04696208
117NMYC_18555785_Chip-Seq_ESCs_Mouse1.04480580
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03781939
119JUN_21703547_ChIP-Seq_K562_Human1.03449170
120STAT3_18555785_Chip-Seq_ESCs_Mouse1.03408365
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02553536
122* TP53_20018659_ChIP-ChIP_R1E_Mouse1.02286453
123AR_25329375_ChIP-Seq_VCAP_Human1.02000663
124FLI1_21867929_ChIP-Seq_TH2_Mouse1.01820265
125NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01742727
126TCF4_23295773_ChIP-Seq_U87_Human1.01556607
127TP53_16413492_ChIP-PET_HCT116_Human1.01337235
128PIAS1_25552417_ChIP-Seq_VCAP_Human1.01067240
129NANOG_19829295_ChIP-Seq_ESCs_Human0.99519521
130SOX2_19829295_ChIP-Seq_ESCs_Human0.99519521
131TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99432675
132ERG_21242973_ChIP-ChIP_JURKAT_Human0.97187508
133CTCF_18555785_Chip-Seq_ESCs_Mouse0.97007408
134SOX2_18555785_Chip-Seq_ESCs_Mouse0.96652980
135MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96597393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation3.89620223
2MP0003880_abnormal_central_pattern3.85488278
3MP0006292_abnormal_olfactory_placode3.73420749
4MP0004859_abnormal_synaptic_plasticity3.59130994
5MP0005645_abnormal_hypothalamus_physiol3.06197429
6MP0003122_maternal_imprinting2.79724512
7MP0005171_absent_coat_pigmentation2.62927962
8MP0003635_abnormal_synaptic_transmissio2.45132109
9MP0004885_abnormal_endolymph2.33523049
10MP0003787_abnormal_imprinting2.32369892
11MP0002063_abnormal_learning/memory/cond2.24688946
12MP0002572_abnormal_emotion/affect_behav2.17249042
13MP0009745_abnormal_behavioral_response2.14357376
14MP0003121_genomic_imprinting1.96287013
15MP0006276_abnormal_autonomic_nervous1.89796919
16MP0002837_dystrophic_cardiac_calcinosis1.89491333
17MP0005646_abnormal_pituitary_gland1.87051168
18MP0001486_abnormal_startle_reflex1.86891994
19MP0005551_abnormal_eye_electrophysiolog1.83212274
20MP0005423_abnormal_somatic_nervous1.78831445
21MP0009046_muscle_twitch1.77635700
22MP0003011_delayed_dark_adaptation1.75350680
23MP0002064_seizures1.74098967
24MP0005379_endocrine/exocrine_gland_phen1.73217082
25MP0000631_abnormal_neuroendocrine_gland1.72070687
26MP0002557_abnormal_social/conspecific_i1.71943938
27MP0001968_abnormal_touch/_nociception1.69805732
28MP0000015_abnormal_ear_pigmentation1.67159671
29MP0000778_abnormal_nervous_system1.63166773
30MP0001905_abnormal_dopamine_level1.61621028
31MP0001501_abnormal_sleep_pattern1.57872710
32MP0001485_abnormal_pinna_reflex1.57145056
33MP0002938_white_spotting1.54995344
34MP0004134_abnormal_chest_morphology1.54701538
35MP0001440_abnormal_grooming_behavior1.54678061
36MP0002277_abnormal_respiratory_mucosa1.52040144
37MP0009379_abnormal_foot_pigmentation1.50568551
38MP0005084_abnormal_gallbladder_morpholo1.43945951
39MP0005409_darkened_coat_color1.42898627
40MP0002160_abnormal_reproductive_system1.41426729
41MP0005248_abnormal_Harderian_gland1.41065356
42MP0002822_catalepsy1.40856059
43MP0006072_abnormal_retinal_apoptosis1.37220772
44MP0004858_abnormal_nervous_system1.37129383
45MP0002184_abnormal_innervation1.36979997
46MP0002909_abnormal_adrenal_gland1.36945247
47MP0002067_abnormal_sensory_capabilities1.36564097
48MP0004270_analgesia1.35058409
49MP0002736_abnormal_nociception_after1.34541072
50MP0003195_calcinosis1.34400024
51MP0005174_abnormal_tail_pigmentation1.34360535
52MP0005389_reproductive_system_phenotype1.33988779
53MP0004145_abnormal_muscle_electrophysio1.33323339
54MP0002009_preneoplasia1.32523470
55MP0003283_abnormal_digestive_organ1.32363520
56MP0003941_abnormal_skin_development1.30137284
57MP0008872_abnormal_physiological_respon1.29965353
58MP0003890_abnormal_embryonic-extraembry1.28025474
59MP0002272_abnormal_nervous_system1.27074384
60MP0002163_abnormal_gland_morphology1.26095835
61MP0008057_abnormal_DNA_replication1.25897699
62MP0004924_abnormal_behavior1.25860693
63MP0005386_behavior/neurological_phenoty1.25860693
64MP0003119_abnormal_digestive_system1.25458986
65MP0001502_abnormal_circadian_rhythm1.24345367
66MP0002102_abnormal_ear_morphology1.23886837
67MP0008877_abnormal_DNA_methylation1.20346515
68MP0000049_abnormal_middle_ear1.20112607
69MP0002734_abnormal_mechanical_nocicepti1.18255049
70MP0002733_abnormal_thermal_nociception1.16337730
71MP0001970_abnormal_pain_threshold1.15462489
72MP0002751_abnormal_autonomic_nervous1.15414068
73MP0004142_abnormal_muscle_tone1.11294779
74MP0000678_abnormal_parathyroid_gland1.10392974
75MP0003937_abnormal_limbs/digits/tail_de1.10164658
76MP0002249_abnormal_larynx_morphology1.09068445
77MP0001944_abnormal_pancreas_morphology1.06316061
78MP0005253_abnormal_eye_physiology1.04790887
79MP0004811_abnormal_neuron_physiology1.04437520
80MP0003136_yellow_coat_color1.03542091
81MP0002928_abnormal_bile_duct1.01924690
82MP0001919_abnormal_reproductive_system1.01334689
83MP0008995_early_reproductive_senescence1.01033072
84MP0003755_abnormal_palate_morphology0.99253158
85MP0000955_abnormal_spinal_cord0.97671532
86MP0003942_abnormal_urinary_system0.95879572
87MP0002735_abnormal_chemical_nociception0.95220872
88MP0005187_abnormal_penis_morphology0.95177439
89MP0003938_abnormal_ear_development0.93984015
90MP0003315_abnormal_perineum_morphology0.93974702
91MP0002882_abnormal_neuron_morphology0.93410662
92MP0000681_abnormal_thyroid_gland0.93023741
93MP0005394_taste/olfaction_phenotype0.92558234
94MP0005499_abnormal_olfactory_system0.92558234
95MP0002152_abnormal_brain_morphology0.92382126
96MP0002116_abnormal_craniofacial_bone0.90878100
97MP0005075_abnormal_melanosome_morpholog0.90753166
98MP0005195_abnormal_posterior_eye0.89888853
99MP0002177_abnormal_outer_ear0.89668905
100MP0002653_abnormal_ependyma_morphology0.89490009
101MP0003633_abnormal_nervous_system0.88630000
102MP0000639_abnormal_adrenal_gland0.87216495
103MP0002138_abnormal_hepatobiliary_system0.85966048
104MP0000569_abnormal_digit_pigmentation0.85840869
105MP0000613_abnormal_salivary_gland0.85677545
106MP0008004_abnormal_stomach_pH0.84947862
107MP0004742_abnormal_vestibular_system0.84409201
108MP0009780_abnormal_chondrocyte_physiolo0.84405377
109MP0003861_abnormal_nervous_system0.83469799
110MP0010030_abnormal_orbit_morphology0.82589216
111MP0002066_abnormal_motor_capabilities/c0.81971863
112MP0003567_abnormal_fetal_cardiomyocyte0.80785290
113MP0003385_abnormal_body_wall0.80150050
114MP0004133_heterotaxia0.79916473
115MP0002075_abnormal_coat/hair_pigmentati0.78814802
116MP0002114_abnormal_axial_skeleton0.78394368
117MP0002638_abnormal_pupillary_reflex0.77406639
118MP0008569_lethality_at_weaning0.76828495
119MP0009250_abnormal_appendicular_skeleto0.75060874
120MP0000026_abnormal_inner_ear0.74906120
121MP0003879_abnormal_hair_cell0.74155574
122MP0001293_anophthalmia0.72943381
123MP0001529_abnormal_vocalization0.72809515
124MP0003123_paternal_imprinting0.72379141
125MP0001186_pigmentation_phenotype0.71851222
126MP0001984_abnormal_olfaction0.71506147
127MP0002752_abnormal_somatic_nervous0.70759449
128MP0003935_abnormal_craniofacial_develop0.70522943
129MP0000566_synostosis0.70048194
130MP0001963_abnormal_hearing_physiology0.68943227
131MP0002876_abnormal_thyroid_physiology0.67205874
132MP0002095_abnormal_skin_pigmentation0.64564491
133MP0000372_irregular_coat_pigmentation0.63299197

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)4.51344572
2Focal motor seizures (HP:0011153)4.32396709
3Pendular nystagmus (HP:0012043)3.67720920
4Epileptic encephalopathy (HP:0200134)3.54563148
5True hermaphroditism (HP:0010459)3.30548413
6Pancreatic fibrosis (HP:0100732)3.02701304
7Pancreatic cysts (HP:0001737)3.00158025
8Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99015840
9Genetic anticipation (HP:0003743)2.83121298
10Rib fusion (HP:0000902)2.81449364
11Abolished electroretinogram (ERG) (HP:0000550)2.77575919
12Abnormal rod and cone electroretinograms (HP:0008323)2.76871022
13Focal seizures (HP:0007359)2.73463784
14Agitation (HP:0000713)2.72970587
15Absent rod-and cone-mediated responses on ERG (HP:0007688)2.70640613
16Chromsome breakage (HP:0040012)2.68598625
17Congenital stationary night blindness (HP:0007642)2.66616646
18Congenital, generalized hypertrichosis (HP:0004540)2.63191391
19Increased corneal curvature (HP:0100692)2.60975920
20Keratoconus (HP:0000563)2.60975920
21Conjunctival hamartoma (HP:0100780)2.58892632
22Rectovaginal fistula (HP:0000143)2.57157899
23Rectal fistula (HP:0100590)2.57157899
24Acute necrotizing encephalopathy (HP:0006965)2.50456005
25Abnormality of the phalanges of the hallux (HP:0010057)2.50047916
26Drooling (HP:0002307)2.49588079
27Excessive salivation (HP:0003781)2.49588079
28Abnormality of the middle phalanges of the toes (HP:0010183)2.48928118
29Intestinal fistula (HP:0100819)2.44034254
30Atonic seizures (HP:0010819)2.42472832
31Decreased central vision (HP:0007663)2.41871739
32Annular pancreas (HP:0001734)2.40386158
33Furrowed tongue (HP:0000221)2.37299326
343-Methylglutaconic aciduria (HP:0003535)2.37015229
35Progressive macrocephaly (HP:0004481)2.36542163
36Volvulus (HP:0002580)2.34450409
37Prostate neoplasm (HP:0100787)2.33073378
38Tented upper lip vermilion (HP:0010804)2.32055679
39Methylmalonic acidemia (HP:0002912)2.31290307
40Congenital sensorineural hearing impairment (HP:0008527)2.30421790
41Hypothermia (HP:0002045)2.30023782
42Dialeptic seizures (HP:0011146)2.28770807
43Type II lissencephaly (HP:0007260)2.27765181
44Action tremor (HP:0002345)2.25795029
45Medial flaring of the eyebrow (HP:0010747)2.25709745
46Short hallux (HP:0010109)2.24978198
47Asplenia (HP:0001746)2.23808176
48Meningioma (HP:0002858)2.22985261
49Aplasia/Hypoplasia of the spleen (HP:0010451)2.22675956
50Bilateral microphthalmos (HP:0007633)2.19802108
51Visual hallucinations (HP:0002367)2.18610132
52Hyperventilation (HP:0002883)2.17574690
53Anosmia (HP:0000458)2.15850072
54Mitochondrial inheritance (HP:0001427)2.15654901
55Embryonal renal neoplasm (HP:0011794)2.15481438
56Hypochromic microcytic anemia (HP:0004840)2.15264369
57Small hand (HP:0200055)2.14681811
58Aplasia/Hypoplasia of the hallux (HP:0008362)2.14282903
59Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14256092
60Short 4th metacarpal (HP:0010044)2.14256092
61Nephroblastoma (Wilms tumor) (HP:0002667)2.14047489
62Bifid tongue (HP:0010297)2.13696885
63Osteomalacia (HP:0002749)2.12044407
64Abnormality of the phalanges of the 2nd finger (HP:0009541)2.11226401
65Megalencephaly (HP:0001355)2.11144700
66Renal Fanconi syndrome (HP:0001994)2.10859439
67Increased hepatocellular lipid droplets (HP:0006565)2.10589033
68Abnormality of the renal medulla (HP:0100957)2.08873910
69Polyphagia (HP:0002591)2.08486257
70Abnormal sex determination (HP:0012244)2.08024589
71Sex reversal (HP:0012245)2.08024589
72Absent speech (HP:0001344)2.07954410
73Adrenal hypoplasia (HP:0000835)2.07650075
74Narrow nasal bridge (HP:0000446)2.04218994
75Hamartoma of the eye (HP:0010568)2.04210236
76Absence seizures (HP:0002121)2.02742529
77Genital tract atresia (HP:0001827)2.02084541
78Amblyopia (HP:0000646)2.01171406
79Broad-based gait (HP:0002136)2.01098578
80Decreased circulating renin level (HP:0003351)2.00722302
81Abnormality of the labia minora (HP:0012880)2.00607354
82Increased number of teeth (HP:0011069)2.00189919
83Increased IgM level (HP:0003496)1.99942270
84Absent eyebrow (HP:0002223)1.99643138
85Abnormality of male internal genitalia (HP:0000022)1.99435999
86Vaginal atresia (HP:0000148)1.98247691
87Myokymia (HP:0002411)1.98229584
88Abnormality of renal resorption (HP:0011038)1.96077534
89Confusion (HP:0001289)1.95750622
90Obstructive sleep apnea (HP:0002870)1.93071299
91Acute encephalopathy (HP:0006846)1.92974220
92Cystic liver disease (HP:0006706)1.92532771
93Sclerocornea (HP:0000647)1.92019715
94Lipid accumulation in hepatocytes (HP:0006561)1.91609488
95Abnormal mitochondria in muscle tissue (HP:0008316)1.91437553
96Cheilitis (HP:0100825)1.89003170
97Protruding tongue (HP:0010808)1.88922559
98Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.88720784
99Synostosis involving the elbow (HP:0003938)1.86810024
100Humeroradial synostosis (HP:0003041)1.86810024
101Abnormality of the renal cortex (HP:0011035)1.86747018
102Abnormality of the proximal phalanges of the hand (HP:0009834)1.86712541
103Midline defect of the nose (HP:0004122)1.86539704
104Concave nail (HP:0001598)1.85144761
105Iris hypopigmentation (HP:0007730)1.83953139
106Supernumerary spleens (HP:0009799)1.83865983
107Short tibia (HP:0005736)1.83790120
108Increased CSF lactate (HP:0002490)1.83452822
109Molar tooth sign on MRI (HP:0002419)1.83367398
110Abnormality of midbrain morphology (HP:0002418)1.83367398
111Vaginal fistula (HP:0004320)1.82520854
112Symphalangism affecting the phalanges of the hand (HP:0009773)1.81918600
113Generalized tonic-clonic seizures (HP:0002069)1.81531073
114Abnormality of the 4th metacarpal (HP:0010012)1.81278287
115Cutaneous finger syndactyly (HP:0010554)1.81205075
116Goiter (HP:0000853)1.81196250
117Diplopia (HP:0000651)1.81129596
118Abnormality of binocular vision (HP:0011514)1.81129596
119Chorioretinal atrophy (HP:0000533)1.80541567
120Progressive cerebellar ataxia (HP:0002073)1.80497055
121Specific learning disability (HP:0001328)1.78197088
122Attenuation of retinal blood vessels (HP:0007843)1.77881127
123Facial hemangioma (HP:0000329)1.77801974
124Degeneration of the lateral corticospinal tracts (HP:0002314)1.77787133
125Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77787133
126Abnormality of the phalanges of the 5th finger (HP:0004213)1.76434118
127Aplasia/Hypoplasia of the tibia (HP:0005772)1.76264972
128Optic disc pallor (HP:0000543)1.75663347
129Stenosis of the external auditory canal (HP:0000402)1.75549806
130Hemiparesis (HP:0001269)1.75155635
131Fetal akinesia sequence (HP:0001989)1.73922051
132Dysdiadochokinesis (HP:0002075)1.73719270
133Horizontal nystagmus (HP:0000666)1.73609995
134Hypoplasia of the uterus (HP:0000013)1.73358445
135Deeply set eye (HP:0000490)1.72946129
136Duplication of thumb phalanx (HP:0009942)1.72917226
137Abnormal respiratory motile cilium morphology (HP:0005938)1.72110751
138Abnormal respiratory epithelium morphology (HP:0012253)1.72110751
139Absent septum pellucidum (HP:0001331)1.71503256
140Abnormal hair whorl (HP:0010721)1.70211646
141Anomalous pulmonary venous return (HP:0010772)1.69443428
142Male pseudohermaphroditism (HP:0000037)1.69037223
143Limb dystonia (HP:0002451)1.68408329
144Cutaneous syndactyly (HP:0012725)1.67964971
145Sleep apnea (HP:0010535)1.64096826
146Gaze-evoked nystagmus (HP:0000640)1.62956930
147Narrow forehead (HP:0000341)1.62867120
148Generalized hypopigmentation of hair (HP:0011358)1.62831098
149High anterior hairline (HP:0009890)1.62152564
150Gait imbalance (HP:0002141)1.61985737
151Ocular albinism (HP:0001107)1.61460093
152Open mouth (HP:0000194)1.60700535
153Aplasia cutis congenita (HP:0001057)1.60411689
154Abnormality of chromosome segregation (HP:0002916)1.59404671
155Septo-optic dysplasia (HP:0100842)1.58558218
156Abnormality of the nasal septum (HP:0000419)1.57988603
157Short humerus (HP:0005792)1.56578735
158Abnormality of the astrocytes (HP:0100707)1.56458546
159Astrocytoma (HP:0009592)1.56458546
160Gastroesophageal reflux (HP:0002020)1.56228171
161Nephrogenic diabetes insipidus (HP:0009806)1.55402052
162Anal atresia (HP:0002023)1.54156419
163Inability to walk (HP:0002540)1.53928732
164Widely spaced teeth (HP:0000687)1.53837686
165Aplasia/Hypoplasia of the uvula (HP:0010293)1.52621576
166Abnormality of the ileum (HP:0001549)1.52440322
167Abnormality of salivation (HP:0100755)1.51598577
168Hepatoblastoma (HP:0002884)1.51076121
169Dynein arm defect of respiratory motile cilia (HP:0012255)1.49804774
170Absent/shortened dynein arms (HP:0200106)1.49804774
171Nephronophthisis (HP:0000090)1.48781706
172Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.47777478
173Aplasia/hypoplasia of the humerus (HP:0006507)1.46066063
174Optic nerve hypoplasia (HP:0000609)1.45511025
175Fair hair (HP:0002286)1.44506014
176Postaxial hand polydactyly (HP:0001162)1.43952984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.82505947
2NTRK33.75034308
3FRK3.00273922
4CDK122.77288579
5AKT32.55017842
6TAF12.54779588
7MARK12.50649238
8PNCK2.42342338
9MAP2K72.41593253
10WNK32.39001792
11MAP3K122.34038509
12MAP3K92.27697806
13GRK72.24781110
14NUAK12.20650608
15EPHA42.15159267
16GRK52.13348729
17SIK22.09380220
18SIK32.06181039
19MAP3K62.04099717
20FGFR21.74843742
21TNIK1.74026790
22PRPF4B1.72273473
23NTRK21.71823792
24WNK41.69615047
25YES11.67141784
26MAPK131.62398440
27PRKD21.57583148
28TNK21.53032395
29ADRBK21.50675680
30STK161.46981908
31MAP3K41.41699284
32PHKG11.41605763
33PHKG21.41605763
34CDK81.39555659
35UHMK11.39099140
36DAPK11.38885786
37VRK21.37978906
38MAP2K41.35951974
39TAOK31.35173126
40FGR1.32586357
41TYRO31.31419181
42CSNK1G11.28072568
43SRPK11.26380081
44LATS21.24755480
45MINK11.19205839
46CDK31.16025041
47STK381.14516294
48CDK71.13150777
49INSRR1.10523603
50DDR21.09836736
51KSR11.09653641
52PAK31.08030533
53MATK1.05006006
54SGK21.02886305
55GRK60.99421226
56PLK20.97058089
57BRD40.96207987
58STK110.95172979
59MAP2K60.94592260
60ZAK0.94440612
61CSNK1G30.94038250
62PINK10.93858913
63PRKCE0.91889401
64ERBB30.91726170
65MAPK150.90828881
66CAMK2A0.90649795
67CAMK40.90374360
68CHEK20.89138443
69TGFBR20.89113187
70EIF2AK20.88934740
71MAPKAPK50.86838547
72STK390.85506443
73WEE10.84771229
74GRK10.82547927
75VRK10.81901352
76FES0.81883144
77NLK0.81676399
78HIPK20.81598107
79RIPK40.79169273
80MAPK70.78214670
81MUSK0.77699901
82OXSR10.77645180
83MARK20.77164624
84CAMK10.75946090
85DAPK20.71722639
86TXK0.71528548
87TIE10.70012291
88ADRBK10.68748662
89MAP4K20.68169547
90CDK50.67601439
91SGK10.66615509
92ALK0.66196490
93SGK30.64258214
94CSNK1A1L0.62817000
95MKNK20.62310365
96PRKACA0.62198215
97RAF10.60999852
98BRSK20.58464947
99MAPK120.57213635
100ACVR1B0.54419957
101CAMK2B0.54281983
102DMPK0.53803231
103EPHB20.52930198
104CSNK1A10.52774713
105BCKDK0.52559346
106BMPR20.51250125
107PRKCG0.51061169
108CDK60.50675438
109BMPR1B0.50642249
110SGK2230.50340194
111SGK4940.50340194
112PKN10.50206983
113MAPK100.50170195
114PIK3CA0.49289046
115CAMKK10.47025135
116PRKG10.46914960
117TRIM280.45973063
118MOS0.45742806
119CSNK1E0.43655127
120CSNK1D0.43164162
121CAMKK20.43027194
122PRKD30.42981615
123RPS6KB10.42935851
124NME10.42687756
125DYRK1A0.41827271
126FGFR10.41570074
127ERBB20.40985342
128PRKCZ0.40944839
129BMX0.40832487
130PLK30.40652831
131PRKG20.40551427
132CAMK2D0.39626217
133AKT20.38761266
134GSK3B0.38696704
135CDC70.38107615
136CSNK1G20.38006088
137TLK10.37674267
138GSK3A0.37646361
139CSK0.36682145
140PASK0.36675517
141ICK0.36673211
142PRKCH0.36223610
143PRKCA0.35841037
144MST40.35509322
145MAPK140.35346942
146CAMK1G0.34755067
147NTRK10.33641975
148CDK190.33350688
149RPS6KA30.33244903
150PAK60.33069572
151DYRK20.31665063

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.50998770
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.31246603
3Oxidative phosphorylation_Homo sapiens_hsa001903.03534062
4Parkinsons disease_Homo sapiens_hsa050122.32259362
5Cardiac muscle contraction_Homo sapiens_hsa042602.16348461
6Protein export_Homo sapiens_hsa030602.06328817
7Morphine addiction_Homo sapiens_hsa050321.93287772
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93026926
9Glutamatergic synapse_Homo sapiens_hsa047241.91884019
10Alzheimers disease_Homo sapiens_hsa050101.87443000
11Long-term potentiation_Homo sapiens_hsa047201.86503995
12Olfactory transduction_Homo sapiens_hsa047401.76502174
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76304848
14Circadian entrainment_Homo sapiens_hsa047131.76028634
15GABAergic synapse_Homo sapiens_hsa047271.74888074
16Serotonergic synapse_Homo sapiens_hsa047261.69412351
17Taste transduction_Homo sapiens_hsa047421.69298803
18Amphetamine addiction_Homo sapiens_hsa050311.68748908
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62429313
20Long-term depression_Homo sapiens_hsa047301.60448503
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59012740
22Synaptic vesicle cycle_Homo sapiens_hsa047211.58345739
23Folate biosynthesis_Homo sapiens_hsa007901.58169249
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56560080
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47994798
26Huntingtons disease_Homo sapiens_hsa050161.44862857
27GnRH signaling pathway_Homo sapiens_hsa049121.43032769
28Dopaminergic synapse_Homo sapiens_hsa047281.39790852
29Renin secretion_Homo sapiens_hsa049241.35387731
30Wnt signaling pathway_Homo sapiens_hsa043101.34561833
31Axon guidance_Homo sapiens_hsa043601.33684405
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32897150
33Cocaine addiction_Homo sapiens_hsa050301.30992274
34Selenocompound metabolism_Homo sapiens_hsa004501.30510263
35Linoleic acid metabolism_Homo sapiens_hsa005911.25640227
36Calcium signaling pathway_Homo sapiens_hsa040201.24342344
37Cholinergic synapse_Homo sapiens_hsa047251.22526706
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22513551
39Salivary secretion_Homo sapiens_hsa049701.21647819
40Ribosome_Homo sapiens_hsa030101.19724325
41Nitrogen metabolism_Homo sapiens_hsa009101.17754862
42Oxytocin signaling pathway_Homo sapiens_hsa049211.17115379
43Tryptophan metabolism_Homo sapiens_hsa003801.16419111
44Butanoate metabolism_Homo sapiens_hsa006501.11433193
45ErbB signaling pathway_Homo sapiens_hsa040121.08948047
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07808133
47Gap junction_Homo sapiens_hsa045401.07271332
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06103757
49Insulin secretion_Homo sapiens_hsa049111.05827736
50Basal transcription factors_Homo sapiens_hsa030221.04735541
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03703373
52cAMP signaling pathway_Homo sapiens_hsa040241.03628449
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03302904
54Melanogenesis_Homo sapiens_hsa049161.01162269
55Colorectal cancer_Homo sapiens_hsa052101.00417593
56Vitamin digestion and absorption_Homo sapiens_hsa049771.00027445
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99857660
58Ovarian steroidogenesis_Homo sapiens_hsa049130.98677216
59Basal cell carcinoma_Homo sapiens_hsa052170.97352140
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97236314
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96442354
62MAPK signaling pathway_Homo sapiens_hsa040100.95085729
63Circadian rhythm_Homo sapiens_hsa047100.93982355
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91405671
65Ether lipid metabolism_Homo sapiens_hsa005650.91159690
66Hedgehog signaling pathway_Homo sapiens_hsa043400.87654800
67Retinol metabolism_Homo sapiens_hsa008300.87215531
68Dorso-ventral axis formation_Homo sapiens_hsa043200.87173497
69Fanconi anemia pathway_Homo sapiens_hsa034600.86722839
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85675398
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85429988
72Choline metabolism in cancer_Homo sapiens_hsa052310.83073873
73Gastric acid secretion_Homo sapiens_hsa049710.82986540
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82963235
75Sulfur metabolism_Homo sapiens_hsa009200.81646021
76Chemical carcinogenesis_Homo sapiens_hsa052040.80792756
77Ras signaling pathway_Homo sapiens_hsa040140.79568360
78Endometrial cancer_Homo sapiens_hsa052130.79096448
79Hippo signaling pathway_Homo sapiens_hsa043900.78525024
80mRNA surveillance pathway_Homo sapiens_hsa030150.78477786
81Rap1 signaling pathway_Homo sapiens_hsa040150.78451558
82Phototransduction_Homo sapiens_hsa047440.77722155
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77557817
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77453840
85Glioma_Homo sapiens_hsa052140.76801471
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.76540357
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75572103
88RNA polymerase_Homo sapiens_hsa030200.74623762
89Peroxisome_Homo sapiens_hsa041460.72464509
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72441286
91African trypanosomiasis_Homo sapiens_hsa051430.71733135
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70208785
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69924861
94Estrogen signaling pathway_Homo sapiens_hsa049150.69698015
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68753466
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68627124
97VEGF signaling pathway_Homo sapiens_hsa043700.67599783
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66178548
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.66040904
100Oocyte meiosis_Homo sapiens_hsa041140.65568814
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.65091116
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64528571
103Adherens junction_Homo sapiens_hsa045200.64027946
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63607072
105Notch signaling pathway_Homo sapiens_hsa043300.63201132
106Propanoate metabolism_Homo sapiens_hsa006400.61154627
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60058079
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.59366009
109Melanoma_Homo sapiens_hsa052180.59041310
110Acute myeloid leukemia_Homo sapiens_hsa052210.57777089
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57378587
112Prolactin signaling pathway_Homo sapiens_hsa049170.57301610
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57283198
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56726714
115Graft-versus-host disease_Homo sapiens_hsa053320.56125425
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.55714236
117Collecting duct acid secretion_Homo sapiens_hsa049660.55512294
118Pathways in cancer_Homo sapiens_hsa052000.55318057
119Mineral absorption_Homo sapiens_hsa049780.55312657
120mTOR signaling pathway_Homo sapiens_hsa041500.55054962
121Thyroid cancer_Homo sapiens_hsa052160.54958579
122Autoimmune thyroid disease_Homo sapiens_hsa053200.54947491
123Caffeine metabolism_Homo sapiens_hsa002320.54807819
124Sulfur relay system_Homo sapiens_hsa041220.53891051
125Thyroid hormone synthesis_Homo sapiens_hsa049180.53831847
126Inositol phosphate metabolism_Homo sapiens_hsa005620.52308396
127Vitamin B6 metabolism_Homo sapiens_hsa007500.51534653
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51361746
129TGF-beta signaling pathway_Homo sapiens_hsa043500.50795261
130Fat digestion and absorption_Homo sapiens_hsa049750.50542610
131MicroRNAs in cancer_Homo sapiens_hsa052060.48653594
132Type II diabetes mellitus_Homo sapiens_hsa049300.48572290
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48197824
134T cell receptor signaling pathway_Homo sapiens_hsa046600.48129247
135Homologous recombination_Homo sapiens_hsa034400.47934572
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47648205
137Chemokine signaling pathway_Homo sapiens_hsa040620.47306491
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46032358
139RNA degradation_Homo sapiens_hsa030180.45664761
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45212642
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44674746
142FoxO signaling pathway_Homo sapiens_hsa040680.44258248
143Regulation of autophagy_Homo sapiens_hsa041400.42644668
144Histidine metabolism_Homo sapiens_hsa003400.41770171
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40652064
146One carbon pool by folate_Homo sapiens_hsa006700.40007649
147Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39263847
148beta-Alanine metabolism_Homo sapiens_hsa004100.37242907
149Primary bile acid biosynthesis_Homo sapiens_hsa001200.35648311

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