USP28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.03752366
2nuclear pore complex assembly (GO:0051292)5.02812036
3cardiac myofibril assembly (GO:0055003)4.62949435
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.58638025
5sarcoplasmic reticulum calcium ion transport (GO:0070296)4.49293884
6regulation of gene silencing by RNA (GO:0060966)4.44229030
7regulation of posttranscriptional gene silencing (GO:0060147)4.44229030
8regulation of gene silencing by miRNA (GO:0060964)4.44229030
9mitotic chromosome condensation (GO:0007076)4.40880910
10paraxial mesoderm development (GO:0048339)4.35957520
11sarcomere organization (GO:0045214)4.19360017
12cardiac muscle hypertrophy (GO:0003300)4.09323118
13negative regulation of potassium ion transmembrane transport (GO:1901380)3.98583615
14regulation of relaxation of muscle (GO:1901077)3.97160944
15protein localization to kinetochore (GO:0034501)3.96215601
16pre-miRNA processing (GO:0031054)3.93519669
17mitotic metaphase plate congression (GO:0007080)3.88072862
18striated muscle hypertrophy (GO:0014897)3.85172536
19myofibril assembly (GO:0030239)3.84795469
20negative regulation of histone methylation (GO:0031061)3.82117491
21regulation of actin filament-based movement (GO:1903115)3.80864110
22cardiac muscle cell development (GO:0055013)3.79090377
23actin filament-based movement (GO:0030048)3.73791880
24actin-myosin filament sliding (GO:0033275)3.73731122
25muscle filament sliding (GO:0030049)3.73731122
26regulation of meiosis I (GO:0060631)3.71208486
27piRNA metabolic process (GO:0034587)3.68039465
28establishment of integrated proviral latency (GO:0075713)3.64653571
29mitotic nuclear envelope disassembly (GO:0007077)3.64168566
30ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.62655736
31cardiac cell development (GO:0055006)3.58858018
32bundle of His cell to Purkinje myocyte communication (GO:0086069)3.53701271
33pore complex assembly (GO:0046931)3.52519615
34chromatin remodeling at centromere (GO:0031055)3.51498439
35DNA replication-dependent nucleosome assembly (GO:0006335)3.44840438
36DNA replication-dependent nucleosome organization (GO:0034723)3.44840438
37mitotic sister chromatid segregation (GO:0000070)3.43785259
38metaphase plate congression (GO:0051310)3.43608398
39muscle tissue morphogenesis (GO:0060415)3.43469635
40membrane disassembly (GO:0030397)3.42241015
41nuclear envelope disassembly (GO:0051081)3.42241015
42CENP-A containing nucleosome assembly (GO:0034080)3.41765786
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.40437485
44positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.36291949
45regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.35541138
46regulation of helicase activity (GO:0051095)3.34967831
47protein localization to chromosome, centromeric region (GO:0071459)3.34684643
48DNA unwinding involved in DNA replication (GO:0006268)3.33617304
49negative regulation of gene silencing (GO:0060969)3.32199024
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.26573011
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.26573011
52protein complex localization (GO:0031503)3.25617399
53cardiac muscle contraction (GO:0060048)3.25503707
54regulation of histone H3-K9 methylation (GO:0051570)3.24390033
55regulation of telomere maintenance via telomerase (GO:0032210)3.19473384
56muscle hypertrophy (GO:0014896)3.18752910
57sister chromatid segregation (GO:0000819)3.18678301
58attachment of spindle microtubules to kinetochore (GO:0008608)3.17981361
59cell fate commitment involved in formation of primary germ layer (GO:0060795)3.17973689
60regulation of spindle organization (GO:0090224)3.17196664
61regulation of mitotic spindle organization (GO:0060236)3.16348159
62DNA replication initiation (GO:0006270)3.15980396
63actin-mediated cell contraction (GO:0070252)3.14996013
64protein K6-linked ubiquitination (GO:0085020)3.12113884
65heterochromatin organization (GO:0070828)3.10904539
66IMP biosynthetic process (GO:0006188)3.10763536
67regulation of DNA endoreduplication (GO:0032875)3.10486966
68regulation of cardioblast differentiation (GO:0051890)3.09990606
69DNA methylation involved in gamete generation (GO:0043046)3.07708914
70mitotic sister chromatid cohesion (GO:0007064)3.07497607
71gene silencing by RNA (GO:0031047)3.07270890
72response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.05310322
73lung-associated mesenchyme development (GO:0060484)3.04788120
74positive regulation of catenin import into nucleus (GO:0035413)3.03022028
75regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.00643132
76negative regulation of meiosis (GO:0045835)2.99480667
77lysine metabolic process (GO:0006553)2.99433979
78lysine catabolic process (GO:0006554)2.99433979
79ventricular cardiac muscle cell action potential (GO:0086005)2.99008998
80protein localization to chromosome (GO:0034502)2.98605503
81histone exchange (GO:0043486)2.97897584
82ventricular cardiac muscle cell development (GO:0055015)2.96830202
83negative regulation of chromosome segregation (GO:0051985)2.96567753
84regulation of sister chromatid cohesion (GO:0007063)2.95696318
85IMP metabolic process (GO:0046040)2.95608033
86DNA alkylation (GO:0006305)2.95180459
87DNA methylation (GO:0006306)2.95180459
88notochord development (GO:0030903)2.95050303
89L-serine metabolic process (GO:0006563)2.94536420
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93610948
91establishment of chromosome localization (GO:0051303)2.92990544
92positive regulation of SMAD protein import into nucleus (GO:0060391)2.92306568
93histone H2A monoubiquitination (GO:0035518)2.92196958
94DNA strand elongation involved in DNA replication (GO:0006271)2.91830750
95regulation of chromatin silencing (GO:0031935)2.90611687
96spindle checkpoint (GO:0031577)2.89018385
97negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85911156
98negative regulation of sister chromatid segregation (GO:0033046)2.85911156
99negative regulation of mitotic sister chromatid separation (GO:2000816)2.85911156
100negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85911156
101histone H4-K8 acetylation (GO:0043982)2.85482270
102histone H4-K5 acetylation (GO:0043981)2.85482270
103DNA replication-independent nucleosome assembly (GO:0006336)2.85100711
104DNA replication-independent nucleosome organization (GO:0034724)2.85100711
105DNA geometric change (GO:0032392)2.84655710
106otic vesicle formation (GO:0030916)2.84425610
107regulation of chromosome segregation (GO:0051983)2.84402295
108DNA duplex unwinding (GO:0032508)2.84046322
109actomyosin structure organization (GO:0031032)2.83981784
110positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.83949212
111positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.83949212
112positive regulation of mitotic sister chromatid separation (GO:1901970)2.83949212
113mitotic spindle checkpoint (GO:0071174)2.83488245
114negative regulation of translation, ncRNA-mediated (GO:0040033)2.83282830
115regulation of translation, ncRNA-mediated (GO:0045974)2.83282830
116negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.83282830
117regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.82707574
118spindle assembly checkpoint (GO:0071173)2.82456370
119kinetochore organization (GO:0051383)2.81676686
120regulation of cofactor metabolic process (GO:0051193)2.81664451
121regulation of coenzyme metabolic process (GO:0051196)2.81664451
122mitotic spindle assembly checkpoint (GO:0007094)2.81652717
123positive regulation of chromosome segregation (GO:0051984)2.81352086
124regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.80739555
125tricarboxylic acid cycle (GO:0006099)2.80646812
126DNA replication checkpoint (GO:0000076)2.80355946
127heart process (GO:0003015)2.79237967
128heart contraction (GO:0060047)2.79237967
129regulation of gene silencing (GO:0060968)2.79021736
130regulation of centriole replication (GO:0046599)2.78471547
131regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.77538478
132nuclear envelope organization (GO:0006998)2.77165096
133regulation of skeletal muscle contraction (GO:0014819)2.76724689
134DNA strand elongation (GO:0022616)2.76379697
135ncRNA catabolic process (GO:0034661)2.76375097
136regulation of nuclear cell cycle DNA replication (GO:0033262)2.76061847
137cardiac muscle hypertrophy in response to stress (GO:0014898)2.75927904
138muscle hypertrophy in response to stress (GO:0003299)2.75927904
139cardiac muscle adaptation (GO:0014887)2.75927904
140histone H4-K12 acetylation (GO:0043983)2.75514049
141response to caffeine (GO:0031000)2.74087041
142regulation of mitotic sister chromatid separation (GO:0010965)2.72874140
143regulation of mitotic sister chromatid segregation (GO:0033047)2.72874140
144regulation of sister chromatid segregation (GO:0033045)2.72874140
145striated muscle contraction (GO:0006941)2.72181772
146cardiac muscle tissue morphogenesis (GO:0055008)2.71857549
147adult heart development (GO:0007512)2.71426426
148regulation of mitotic metaphase/anaphase transition (GO:0030071)2.71255557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.75677581
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.42714241
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62665001
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.31174631
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.20893525
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.14550599
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.14111566
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.89535895
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.89535895
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.89535895
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.69809507
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.57852489
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57718963
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50654703
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.43458103
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.40450672
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.32455929
18NANOG_18555785_ChIP-Seq_MESCs_Mouse2.27980687
19SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.22304002
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.21869994
21AR_21909140_ChIP-Seq_LNCAP_Human2.20584117
22ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.18785580
23NANOG_16153702_ChIP-ChIP_HESCs_Human2.09520044
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08132908
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.05705648
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.03024795
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02737926
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.99667923
29* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98001904
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.94367750
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.94117224
32TCF3_18692474_ChIP-Seq_MESCs_Mouse1.91994389
33TCF3_18692474_ChIP-Seq_MEFs_Mouse1.87761725
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.86420834
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.86178905
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85467970
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84637854
38FUS_26573619_Chip-Seq_HEK293_Human1.80564279
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77418420
40SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.77244823
41NANOG_21062744_ChIP-ChIP_HESCs_Human1.75230294
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.73167711
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71727702
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.71280572
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68508476
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.68036470
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66609441
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.66527713
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65369998
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63640224
51* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.61661823
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61070197
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.57369136
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57078219
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56317514
56CIITA_25753668_ChIP-Seq_RAJI_Human1.55424530
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49094117
58MYC_22102868_ChIP-Seq_BL_Human1.48357532
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45309204
60POU5F1_16518401_ChIP-PET_MESCs_Mouse1.44820139
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44309478
62ELK1_19687146_ChIP-ChIP_HELA_Human1.44022249
63VDR_22108803_ChIP-Seq_LS180_Human1.43418640
64EWS_26573619_Chip-Seq_HEK293_Human1.41214572
65XRN2_22483619_ChIP-Seq_HELA_Human1.34122137
66SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.33946309
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33724010
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31774005
69* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30130912
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28246128
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27803076
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27790372
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26487535
74NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.25505922
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25315552
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24517826
77* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23725428
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22061640
79POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.21998630
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19347677
81* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.18324447
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.18054583
83ZNF263_19887448_ChIP-Seq_K562_Human1.17455024
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17346861
85ETS1_20019798_ChIP-Seq_JURKAT_Human1.16885302
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.15440792
87* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.14868887
88KDM5A_27292631_Chip-Seq_BREAST_Human1.14766976
89* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.14610858
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13217392
91CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12927716
92IGF1R_20145208_ChIP-Seq_DFB_Human1.09125631
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08955599
94* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08662674
95MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08247407
96P300_19829295_ChIP-Seq_ESCs_Human1.08088008
97* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.06427425
98GABP_17652178_ChIP-ChIP_JURKAT_Human1.05693453
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05425683
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05265453
101* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.05185232
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05158991
103ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05029779
104TTF2_22483619_ChIP-Seq_HELA_Human1.04154179
105ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04047462
106FOXP3_21729870_ChIP-Seq_TREG_Human1.03644790
107SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03397124
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03327558
109* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03015897
110SOX17_20123909_ChIP-Seq_XEN_Mouse1.01982795
111TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01248042
112* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.00520143
113TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00421941
114NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99572443
115TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98219721
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97935585
117* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97431263
118ISL1_27105846_Chip-Seq_CPCs_Mouse0.96926961
119* GATA1_26923725_Chip-Seq_HPCs_Mouse0.94892539
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94718077
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94410562
122GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94014577
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93114941
124SOX2_16153702_ChIP-ChIP_HESCs_Human0.92659722
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92439894
126SOX9_26525672_Chip-Seq_HEART_Mouse0.91961205
127GBX2_23144817_ChIP-Seq_PC3_Human0.91934876
128GABP_19822575_ChIP-Seq_HepG2_Human0.91873065
129TAF15_26573619_Chip-Seq_HEK293_Human0.91851639
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91763185
131KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.90828040
132EZH2_27294783_Chip-Seq_NPCs_Mouse0.90251854
133JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88582864
134HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88456063
135KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88396370
136* NANOG_16518401_ChIP-PET_MESCs_Mouse0.88190892
137KAP1_27257070_Chip-Seq_ESCs_Mouse0.86805383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.27247004
2MP0004084_abnormal_cardiac_muscle3.90046644
3MP0002837_dystrophic_cardiac_calcinosis3.27062121
4MP0008877_abnormal_DNA_methylation3.13587678
5MP0000751_myopathy2.95843383
6MP0010094_abnormal_chromosome_stability2.87213364
7MP0004215_abnormal_myocardial_fiber2.77314492
8MP0003111_abnormal_nucleus_morphology2.75515365
9MP0004036_abnormal_muscle_relaxation2.70560458
10MP0003077_abnormal_cell_cycle2.49616854
11MP0004957_abnormal_blastocyst_morpholog2.46420397
12MP0008057_abnormal_DNA_replication2.31593567
13MP0003693_abnormal_embryo_hatching2.26244989
14MP0003123_paternal_imprinting2.25599057
15MP0000749_muscle_degeneration2.18807402
16MP0005330_cardiomyopathy2.13660741
17MP0004233_abnormal_muscle_weight2.13462582
18MP0004087_abnormal_muscle_fiber2.10847917
19MP0002653_abnormal_ependyma_morphology2.02389643
20MP0004145_abnormal_muscle_electrophysio1.98092581
21MP0010630_abnormal_cardiac_muscle1.92175928
22MP0003121_genomic_imprinting1.87871284
23MP0002254_reproductive_system_inflammat1.86864450
24MP0002106_abnormal_muscle_physiology1.84042691
25MP0002269_muscular_atrophy1.83905309
26MP0001730_embryonic_growth_arrest1.82592888
27MP0003137_abnormal_impulse_conducting1.81638882
28MP0003567_abnormal_fetal_cardiomyocyte1.80408109
29MP0000750_abnormal_muscle_regeneration1.77456685
30MP0005380_embryogenesis_phenotype1.75096726
31MP0001672_abnormal_embryogenesis/_devel1.75096726
32MP0008058_abnormal_DNA_repair1.71843367
33MP0002127_abnormal_cardiovascular_syste1.71246753
34MP0002972_abnormal_cardiac_muscle1.70884861
35MP0008775_abnormal_heart_ventricle1.69294189
36MP0003984_embryonic_growth_retardation1.65776252
37MP0005620_abnormal_muscle_contractility1.64563357
38MP0002088_abnormal_embryonic_growth/wei1.62119400
39MP0006138_congestive_heart_failure1.58533422
40MP0002084_abnormal_developmental_patter1.57401795
41MP0000350_abnormal_cell_proliferation1.55816857
42MP0002085_abnormal_embryonic_tissue1.55803492
43MP0003787_abnormal_imprinting1.54735450
44MP0001697_abnormal_embryo_size1.52597571
45MP0005385_cardiovascular_system_phenoty1.52126565
46MP0001544_abnormal_cardiovascular_syste1.52126565
47MP0003221_abnormal_cardiomyocyte_apopto1.50890014
48MP0004510_myositis1.49339198
49MP0010352_gastrointestinal_tract_polyps1.44562906
50MP0005369_muscle_phenotype1.43881975
51MP0003119_abnormal_digestive_system1.38633153
52MP0004484_altered_response_of1.38247425
53MP0004197_abnormal_fetal_growth/weight/1.37592688
54MP0008007_abnormal_cellular_replicative1.36239038
55MP0008932_abnormal_embryonic_tissue1.35909499
56MP0001661_extended_life_span1.34152757
57MP0000759_abnormal_skeletal_muscle1.31076051
58MP0002086_abnormal_extraembryonic_tissu1.30433776
59MP0004133_heterotaxia1.30029708
60MP0003718_maternal_effect1.28642407
61MP0003890_abnormal_embryonic-extraembry1.27263052
62MP0002009_preneoplasia1.26752535
63MP0002210_abnormal_sex_determination1.25040667
64MP0000747_muscle_weakness1.22337598
65MP0000266_abnormal_heart_morphology1.17867411
66MP0002080_prenatal_lethality1.17283749
67MP0000537_abnormal_urethra_morphology1.14842375
68MP0003828_pulmonary_edema1.14050328
69MP0003705_abnormal_hypodermis_morpholog1.13353810
70MP0003136_yellow_coat_color1.12758963
71MP0004085_abnormal_heartbeat1.12580980
72MP0002697_abnormal_eye_size1.12556932
73MP0002102_abnormal_ear_morphology1.09707953
74MP0006035_abnormal_mitochondrial_morpho1.09150417
75MP0003786_premature_aging1.06245330
76MP0003950_abnormal_plasma_membrane1.06200110
77MP0003941_abnormal_skin_development1.04614998
78MP0000733_abnormal_muscle_development1.01276829
79MP0001929_abnormal_gametogenesis1.00914514
80MP0002332_abnormal_exercise_endurance1.00688810
81MP0010307_abnormal_tumor_latency0.99906695
82MP0005076_abnormal_cell_differentiation0.99504231
83MP0001145_abnormal_male_reproductive0.98848371
84MP0009672_abnormal_birth_weight0.98406184
85MP0003937_abnormal_limbs/digits/tail_de0.98239414
86MP0010030_abnormal_orbit_morphology0.94921941
87MP0000653_abnormal_sex_gland0.94799175
88MP0005266_abnormal_metabolism0.92246274
89MP0001299_abnormal_eye_distance/0.91008117
90MP0002925_abnormal_cardiovascular_devel0.90572541
91MP0003935_abnormal_craniofacial_develop0.86291605
92MP0004185_abnormal_adipocyte_glucose0.83896262
93MP0001286_abnormal_eye_development0.83737031
94MP0002249_abnormal_larynx_morphology0.82518628
95MP0005248_abnormal_Harderian_gland0.81251411
96MP0008995_early_reproductive_senescence0.79966007
97MP0004130_abnormal_muscle_cell0.79602303
98MP0003806_abnormal_nucleotide_metabolis0.78433142
99MP0003861_abnormal_nervous_system0.78073352
100MP0006072_abnormal_retinal_apoptosis0.78035480
101MP0005187_abnormal_penis_morphology0.77018511
102MP0000049_abnormal_middle_ear0.75765761
103MP0004272_abnormal_basement_membrane0.75499182
104MP0009703_decreased_birth_body0.74790244
105MP0002108_abnormal_muscle_morphology0.74142075
106MP0003566_abnormal_cell_adhesion0.73937880
107MP0005666_abnormal_adipose_tissue0.72283621
108MP0006292_abnormal_olfactory_placode0.72056645
109MP0001849_ear_inflammation0.72009395
110MP0000313_abnormal_cell_death0.71512297
111MP0000579_abnormal_nail_morphology0.71387642
112MP0001119_abnormal_female_reproductive0.70592320
113MP0010368_abnormal_lymphatic_system0.69493444
114MP0001293_anophthalmia0.69435327
115MP0000428_abnormal_craniofacial_morphol0.69103823
116MP0001915_intracranial_hemorrhage0.67557519
117MP0002233_abnormal_nose_morphology0.65591134
118MP0009697_abnormal_copulation0.64504499
119MP0006036_abnormal_mitochondrial_physio0.63200451
120MP0002111_abnormal_tail_morphology0.60078844
121MP0005670_abnormal_white_adipose0.59586649
122MP0009250_abnormal_appendicular_skeleto0.59264627

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.62651387
2Exercise-induced muscle cramps (HP:0003710)4.08411036
3Ependymoma (HP:0002888)3.93409620
4Ventricular tachycardia (HP:0004756)3.75782479
5Atrial fibrillation (HP:0005110)3.54029251
6Exercise-induced myalgia (HP:0003738)3.52947977
7Subaortic stenosis (HP:0001682)3.33709808
8Abnormality of the left ventricular outflow tract (HP:0011103)3.33709808
9Primary atrial arrhythmia (HP:0001692)3.30013033
10Astrocytoma (HP:0009592)3.27101827
11Abnormality of the astrocytes (HP:0100707)3.27101827
12Calf muscle hypertrophy (HP:0008981)3.24268345
13Supraventricular tachycardia (HP:0004755)3.19491355
14Chromsome breakage (HP:0040012)3.14919161
15Abnormality of the labia minora (HP:0012880)3.13928484
16Supraventricular arrhythmia (HP:0005115)3.11373720
17Medulloblastoma (HP:0002885)3.08602978
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.05602657
19Muscle fiber splitting (HP:0003555)3.04543427
20Muscle hypertrophy of the lower extremities (HP:0008968)2.95835552
21Abnormality of the calf musculature (HP:0001430)2.89300269
22Hyporeflexia of lower limbs (HP:0002600)2.89223935
23Lipoatrophy (HP:0100578)2.86042946
24Colon cancer (HP:0003003)2.76873816
25Papillary thyroid carcinoma (HP:0002895)2.76008216
26Distal arthrogryposis (HP:0005684)2.71942851
27Neoplasm of the oral cavity (HP:0100649)2.69378911
28Glioma (HP:0009733)2.62840088
29Myoglobinuria (HP:0002913)2.61376916
30Supernumerary spleens (HP:0009799)2.61210882
31Syncope (HP:0001279)2.60964446
32Centrally nucleated skeletal muscle fibers (HP:0003687)2.57624904
33Rhabdomyolysis (HP:0003201)2.53170030
34Neck muscle weakness (HP:0000467)2.51589654
35Birth length less than 3rd percentile (HP:0003561)2.49616998
36Hepatoblastoma (HP:0002884)2.44746648
37Muscle fiber inclusion bodies (HP:0100299)2.44638520
38Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.44328122
39Nephroblastoma (Wilms tumor) (HP:0002667)2.42888853
40Right ventricular cardiomyopathy (HP:0011663)2.42560234
41Stenosis of the external auditory canal (HP:0000402)2.42121213
42Shawl scrotum (HP:0000049)2.41160156
43Type 1 muscle fiber predominance (HP:0003803)2.38711794
44Ventricular arrhythmia (HP:0004308)2.37162252
45Bilateral microphthalmos (HP:0007633)2.36558477
46Patellar aplasia (HP:0006443)2.35090488
47Embryonal renal neoplasm (HP:0011794)2.32586096
48Calcaneovalgus deformity (HP:0001848)2.30356515
49EMG: neuropathic changes (HP:0003445)2.30026219
50Hypoplastic ischia (HP:0003175)2.29971074
51Increased connective tissue (HP:0009025)2.29523431
52EMG: myopathic abnormalities (HP:0003458)2.29284796
53Hyperglycinuria (HP:0003108)2.27595291
54Difficulty running (HP:0009046)2.26946577
55Dilated cardiomyopathy (HP:0001644)2.26112101
56Aplasia/Hypoplasia of the sternum (HP:0006714)2.25603145
57Abnormal lung lobation (HP:0002101)2.25043414
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.23408620
59Rhabdomyosarcoma (HP:0002859)2.20256823
60Bundle branch block (HP:0011710)2.17473309
61Shoulder girdle muscle weakness (HP:0003547)2.15096087
62Abnormality of the salivary glands (HP:0010286)2.13674373
63Agnosia (HP:0010524)2.09329787
64Aplasia/Hypoplasia of the patella (HP:0006498)2.09176959
65Nemaline bodies (HP:0003798)2.07032852
66Supernumerary ribs (HP:0005815)2.05843457
67Volvulus (HP:0002580)2.05079838
68Abnormality of the lower motor neuron (HP:0002366)2.03175497
69Biliary tract neoplasm (HP:0100574)2.01618055
70Rib fusion (HP:0000902)2.01537711
71Depressed nasal tip (HP:0000437)2.00721563
72Septo-optic dysplasia (HP:0100842)1.99728386
73Selective tooth agenesis (HP:0001592)1.99602260
74Supernumerary bones of the axial skeleton (HP:0009144)1.98371070
75Choanal stenosis (HP:0000452)1.98005970
76Abnormality of the pubic bones (HP:0003172)1.97820998
77Neoplasm of striated muscle (HP:0009728)1.97498144
78Aplasia/Hypoplasia of the uvula (HP:0010293)1.96984535
79Breast hypoplasia (HP:0003187)1.96791108
80Carpal bone hypoplasia (HP:0001498)1.96244257
81Progressive muscle weakness (HP:0003323)1.95751062
82Hip contracture (HP:0003273)1.95551915
83Cystic hygroma (HP:0000476)1.94844380
84Abnormality of serine family amino acid metabolism (HP:0010894)1.93138806
85Abnormality of glycine metabolism (HP:0010895)1.93138806
86Difficulty climbing stairs (HP:0003551)1.91355558
87Hyperglycinemia (HP:0002154)1.91306326
88Abnormality of chromosome segregation (HP:0002916)1.89948173
89Deformed tarsal bones (HP:0008119)1.89908254
90Metaphyseal cupping (HP:0003021)1.89453172
91Meckel diverticulum (HP:0002245)1.89378479
92Abnormality of the ischium (HP:0003174)1.89146535
93Absent phalangeal crease (HP:0006109)1.88757013
94Abnormality of chromosome stability (HP:0003220)1.87782745
95Prolonged QT interval (HP:0001657)1.87140181
96Absent radius (HP:0003974)1.86938398
97Heart block (HP:0012722)1.85453661
98Cutaneous syndactyly (HP:0012725)1.85044641
99Abnormality of the ileum (HP:0001549)1.81941840
100Cortical dysplasia (HP:0002539)1.81777947
101Areflexia of lower limbs (HP:0002522)1.81464363
102Ventricular fibrillation (HP:0001663)1.81359689
103Abnormality of the shoulder girdle musculature (HP:0001435)1.81215965
104Rimmed vacuoles (HP:0003805)1.80944212
105Cutaneous finger syndactyly (HP:0010554)1.79223077
106Myopathic facies (HP:0002058)1.77950067
107Neoplasm of the small intestine (HP:0100833)1.77460537
108Abnormality of the preputium (HP:0100587)1.76506039
109Cafe-au-lait spot (HP:0000957)1.76423283
110Proximal amyotrophy (HP:0007126)1.76358748
111Impulsivity (HP:0100710)1.76331443
112Duplication of thumb phalanx (HP:0009942)1.75560793
113Absent forearm bone (HP:0003953)1.75120761
114Aplasia involving forearm bones (HP:0009822)1.75120761
115Atrioventricular block (HP:0001678)1.75104003
116Male infertility (HP:0003251)1.74594326
117Ectopic kidney (HP:0000086)1.74235324
118Abnormality of the musculature of the pelvis (HP:0001469)1.74113504
119Abnormality of the hip-girdle musculature (HP:0001445)1.74113504
120Gastrointestinal carcinoma (HP:0002672)1.73944470
121Malignant gastrointestinal tract tumors (HP:0006749)1.73944470
122Abnormality of lateral ventricle (HP:0030047)1.72734407
123Absent thumb (HP:0009777)1.72343658
124Adenoma sebaceum (HP:0009720)1.71956245
125Angiofibromas (HP:0010615)1.71956245
126Skull defect (HP:0001362)1.70914069
127Pelvic girdle muscle weakness (HP:0003749)1.70845883
128Short hallux (HP:0010109)1.69369919
129Palpitations (HP:0001962)1.69155073
130Neoplasm of the colon (HP:0100273)1.68902304
131Progressive external ophthalmoplegia (HP:0000590)1.68543571
132Absent eyebrow (HP:0002223)1.68317436
133Abnormal atrioventricular conduction (HP:0005150)1.67657113
134Maternal diabetes (HP:0009800)1.67227028
135Left ventricular hypertrophy (HP:0001712)1.66398570
136Abnormality of the septum pellucidum (HP:0007375)1.65634802
137Aplasia/Hypoplasia of the hallux (HP:0008362)1.64579221
138Multiple enchondromatosis (HP:0005701)1.64281172
139Long clavicles (HP:0000890)1.63246699
140Facial cleft (HP:0002006)1.63171457
141Generalized muscle weakness (HP:0003324)1.62171192
142Fused cervical vertebrae (HP:0002949)1.61269858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.06305707
2NEK13.26115188
3CDC73.24130150
4OBSCN3.17982833
5TTK2.99454238
6PKN22.88604652
7LATS12.79424673
8STK38L2.72235155
9TAF12.71669636
10TTN2.43490355
11PBK2.33230265
12LATS22.15605030
13PDK32.15549681
14PDK42.15549681
15WEE12.10343588
16NEK21.85966660
17CDK191.73266792
18EEF2K1.72574681
19ICK1.69279820
20DMPK1.63704394
21PLK11.62485427
22STK241.54435981
23MUSK1.51870493
24BRD41.47097549
25PHKG21.45988965
26PHKG11.45988965
27PLK41.40784078
28CHEK21.39547810
29CDK71.36297385
30FLT31.28279384
31LMTK21.27192135
32RPS6KB21.26906168
33EIF2AK31.26862282
34CHEK11.24399917
35PNCK1.21374778
36ZAK1.17728919
37BUB11.16733696
38CDK41.14989277
39AURKB1.13339976
40ATR1.11092134
41SRPK11.09119687
42MELK1.09012917
43STK41.05880464
44MAPKAPK31.05092379
45PDK21.04577466
46VRK21.02875072
47TYRO30.97656157
48PLK30.97164271
49KSR10.97158345
50NEK90.95112682
51NUAK10.94410706
52MAP3K100.94390613
53ERBB40.93318893
54KSR20.92915884
55MAP3K80.91810391
56EPHA20.90670174
57CAMK1G0.90473965
58STK380.89806010
59STK30.88797546
60MAP3K60.88698612
61* ATM0.88405211
62MTOR0.87894367
63CDK20.87024721
64WNK30.85579307
65PINK10.85284247
66MAP3K90.84523156
67DYRK30.82811623
68MAP3K40.82406395
69STK100.80763890
70PRKD30.73422116
71TSSK60.72864971
72CDK90.72459144
73TNIK0.71575609
74PASK0.70906974
75VRK10.69684439
76CDK10.69432241
77PRKAA10.68638849
78TRIB30.68356780
79BRSK20.68354716
80MST40.67896564
81AKT20.67180767
82BRAF0.66983513
83AURKA0.66671367
84ACVR1B0.66071154
85CDC42BPA0.65448346
86BMPR1B0.64701481
87FGFR20.64541665
88MOS0.64304748
89CSNK1D0.64149584
90MYLK0.62541799
91PIK3CA0.62447089
92MAP3K50.61591159
93TAOK20.59649827
94PDGFRA0.58791774
95ALK0.58738915
96MKNK20.58234446
97BRSK10.57702471
98FGFR10.53425483
99EIF2AK20.53283531
100AKT30.53162297
101CSNK1E0.51868284
102CDK80.51316153
103MAP3K130.51017952
104RAF10.49137859
105NLK0.48002583
106MAP3K70.47823470
107DYRK20.47796682
108PAK60.46822050
109YES10.45551431
110PIM10.45450277
111MKNK10.45115105
112PRKDC0.43939675
113TGFBR10.43456570
114OXSR10.42992558
115RPS6KA10.42727644
116KDR0.41722744
117ERBB30.41600028
118TIE10.40653350
119GSK3B0.40128882
120BCKDK0.39858376
121MAPK140.39493319
122CAMK40.38500012
123AKT10.37654952
124CAMK1D0.37145076
125PRKAA20.36327245
126BCR0.35975023
127ROCK10.35910205
128SGK20.35825688
129PAK40.34488364
130BMX0.33986255
131STK160.32652333
132CDK60.31950155
133SMG10.30815782
134PRKCE0.30283144
135STK390.30133214
136CSNK2A20.28239513
137CDK30.27974813

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.16352926
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.13060604
3DNA replication_Homo sapiens_hsa030302.91117847
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84734139
5RNA transport_Homo sapiens_hsa030132.76439395
6Cell cycle_Homo sapiens_hsa041102.65890402
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.59500785
8RNA degradation_Homo sapiens_hsa030182.31937680
9mRNA surveillance pathway_Homo sapiens_hsa030152.24886939
10Dilated cardiomyopathy_Homo sapiens_hsa054142.24549986
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.23437215
12Spliceosome_Homo sapiens_hsa030402.15256232
13Cardiac muscle contraction_Homo sapiens_hsa042602.07996536
14Base excision repair_Homo sapiens_hsa034102.07579425
15Homologous recombination_Homo sapiens_hsa034402.04768002
16Fanconi anemia pathway_Homo sapiens_hsa034602.04009196
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01381501
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.84364087
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.83781028
20RNA polymerase_Homo sapiens_hsa030201.82292814
21One carbon pool by folate_Homo sapiens_hsa006701.76459134
22Basal transcription factors_Homo sapiens_hsa030221.73244697
23Nucleotide excision repair_Homo sapiens_hsa034201.69709643
24Oocyte meiosis_Homo sapiens_hsa041141.67563940
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.63067144
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62737965
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.52856472
28Non-homologous end-joining_Homo sapiens_hsa034501.49078583
29Biosynthesis of amino acids_Homo sapiens_hsa012301.48748920
30Carbon metabolism_Homo sapiens_hsa012001.43438126
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37732590
32Adherens junction_Homo sapiens_hsa045201.29935458
33Lysine degradation_Homo sapiens_hsa003101.26366214
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26318990
35Hippo signaling pathway_Homo sapiens_hsa043901.25877278
36p53 signaling pathway_Homo sapiens_hsa041151.22411172
37Basal cell carcinoma_Homo sapiens_hsa052171.18488691
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16335689
39Notch signaling pathway_Homo sapiens_hsa043301.16118520
40MicroRNAs in cancer_Homo sapiens_hsa052061.15037676
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10398495
42mTOR signaling pathway_Homo sapiens_hsa041501.08514464
43Arginine and proline metabolism_Homo sapiens_hsa003301.08181623
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07683855
45Viral myocarditis_Homo sapiens_hsa054161.07366886
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04181053
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.03989039
48TGF-beta signaling pathway_Homo sapiens_hsa043501.01130902
49Tight junction_Homo sapiens_hsa045300.98778512
50Dorso-ventral axis formation_Homo sapiens_hsa043200.93996474
51Pentose phosphate pathway_Homo sapiens_hsa000300.92814899
52Pyrimidine metabolism_Homo sapiens_hsa002400.92349815
53Colorectal cancer_Homo sapiens_hsa052100.88208950
54HIF-1 signaling pathway_Homo sapiens_hsa040660.87110113
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.85879471
56Circadian rhythm_Homo sapiens_hsa047100.85318716
57Glucagon signaling pathway_Homo sapiens_hsa049220.85291808
58Endometrial cancer_Homo sapiens_hsa052130.84042373
59Ribosome_Homo sapiens_hsa030100.83361305
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81189289
61Propanoate metabolism_Homo sapiens_hsa006400.80651727
62HTLV-I infection_Homo sapiens_hsa051660.80444006
63Hedgehog signaling pathway_Homo sapiens_hsa043400.79216541
64Huntingtons disease_Homo sapiens_hsa050160.76208729
65Fatty acid degradation_Homo sapiens_hsa000710.73631819
66Purine metabolism_Homo sapiens_hsa002300.73615535
67Steroid biosynthesis_Homo sapiens_hsa001000.73215738
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70767450
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69936005
70Insulin signaling pathway_Homo sapiens_hsa049100.69826440
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68742292
72Fatty acid metabolism_Homo sapiens_hsa012120.68434005
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68393810
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68252282
75Starch and sucrose metabolism_Homo sapiens_hsa005000.68029655
76Wnt signaling pathway_Homo sapiens_hsa043100.67248137
77Thyroid cancer_Homo sapiens_hsa052160.65952345
78Fatty acid elongation_Homo sapiens_hsa000620.65251757
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65245264
80Proteasome_Homo sapiens_hsa030500.65129241
81Ovarian steroidogenesis_Homo sapiens_hsa049130.61381785
82Oxytocin signaling pathway_Homo sapiens_hsa049210.60989583
83AMPK signaling pathway_Homo sapiens_hsa041520.60818856
84FoxO signaling pathway_Homo sapiens_hsa040680.60375574
85Epstein-Barr virus infection_Homo sapiens_hsa051690.58961748
86Viral carcinogenesis_Homo sapiens_hsa052030.58007378
87Pyruvate metabolism_Homo sapiens_hsa006200.55959751
88Pathways in cancer_Homo sapiens_hsa052000.54948025
89Small cell lung cancer_Homo sapiens_hsa052220.54930386
90Herpes simplex infection_Homo sapiens_hsa051680.51315901
91Focal adhesion_Homo sapiens_hsa045100.50598788
92Renal cell carcinoma_Homo sapiens_hsa052110.48610816
93Fructose and mannose metabolism_Homo sapiens_hsa000510.48226370
94GnRH signaling pathway_Homo sapiens_hsa049120.47258786
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46400976
96Regulation of autophagy_Homo sapiens_hsa041400.46012404
97Insulin resistance_Homo sapiens_hsa049310.45816411
98Non-small cell lung cancer_Homo sapiens_hsa052230.44465510
99Folate biosynthesis_Homo sapiens_hsa007900.43552326
100Proteoglycans in cancer_Homo sapiens_hsa052050.41286404
101Parkinsons disease_Homo sapiens_hsa050120.40748246
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39535979
103Arginine biosynthesis_Homo sapiens_hsa002200.38005984
104Calcium signaling pathway_Homo sapiens_hsa040200.33672622
105Prostate cancer_Homo sapiens_hsa052150.33090395
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32487243
107Long-term potentiation_Homo sapiens_hsa047200.31972714
108MAPK signaling pathway_Homo sapiens_hsa040100.31412773
109Melanoma_Homo sapiens_hsa052180.31024294
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30732262
111Systemic lupus erythematosus_Homo sapiens_hsa053220.30112098
112Choline metabolism in cancer_Homo sapiens_hsa052310.29995632
113Chronic myeloid leukemia_Homo sapiens_hsa052200.29548769
114Estrogen signaling pathway_Homo sapiens_hsa049150.29297356
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.28343949
116Galactose metabolism_Homo sapiens_hsa000520.27234682
117Selenocompound metabolism_Homo sapiens_hsa004500.27083441
118Gap junction_Homo sapiens_hsa045400.26951847
119Pancreatic cancer_Homo sapiens_hsa052120.25970495
120Rap1 signaling pathway_Homo sapiens_hsa040150.23832929
121Metabolic pathways_Homo sapiens_hsa011000.19768597
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19090517
123Melanogenesis_Homo sapiens_hsa049160.17918155
124beta-Alanine metabolism_Homo sapiens_hsa004100.16599746

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