USP32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hepatocyte apoptotic process (GO:0097284)5.98330032
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.45918467
3synaptic vesicle maturation (GO:0016188)5.41868483
4locomotory exploration behavior (GO:0035641)4.95873839
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.95669428
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.76488691
7glutamate secretion (GO:0014047)4.64925133
8synaptic vesicle exocytosis (GO:0016079)4.63114665
9positive regulation of keratinocyte differentiation (GO:0045618)4.54777431
10positive regulation of Cdc42 GTPase activity (GO:0043089)4.51946239
11nuclear pore complex assembly (GO:0051292)4.47411459
12regulation of synaptic vesicle exocytosis (GO:2000300)4.44086366
13vocalization behavior (GO:0071625)4.39989142
14layer formation in cerebral cortex (GO:0021819)4.34702279
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.24661152
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.21239825
17regulation of histone H3-K27 methylation (GO:0061085)4.19171635
18regulation of glutamate receptor signaling pathway (GO:1900449)4.01285997
19protein localization to synapse (GO:0035418)3.99045236
20striated muscle atrophy (GO:0014891)3.94060225
21detection of molecule of bacterial origin (GO:0032490)3.93872638
22histone H3-K36 demethylation (GO:0070544)3.91625027
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.83588316
24regulation of synaptic vesicle transport (GO:1902803)3.82767878
25neurotransmitter secretion (GO:0007269)3.81953212
26exploration behavior (GO:0035640)3.74759948
27regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.72435641
28regulation of neuronal synaptic plasticity (GO:0048168)3.71619811
29regulation of clathrin-mediated endocytosis (GO:2000369)3.67285502
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.66800362
31cerebellar Purkinje cell differentiation (GO:0021702)3.65625121
32skeletal muscle adaptation (GO:0043501)3.64817990
33positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.64140009
34cellular potassium ion homeostasis (GO:0030007)3.61409016
35gamma-aminobutyric acid transport (GO:0015812)3.60376362
36proline transport (GO:0015824)3.57394022
37embryonic camera-type eye morphogenesis (GO:0048596)3.57303982
38modulation by symbiont of host defense response (GO:0052031)3.55538975
39modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.55538975
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.55538975
41positive regulation by organism of defense response of other organism involved in symbiotic interact3.55538975
42modulation by symbiont of host immune response (GO:0052553)3.55538975
43positive regulation by symbiont of host defense response (GO:0052509)3.55538975
44neuronal action potential propagation (GO:0019227)3.52361413
45neuron cell-cell adhesion (GO:0007158)3.51371894
46regulation of RNA export from nucleus (GO:0046831)3.51305303
47muscle atrophy (GO:0014889)3.51077318
48sodium ion export (GO:0071436)3.50447029
49positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.49501852
50nuclear pore organization (GO:0006999)3.49459578
51TOR signaling (GO:0031929)3.44604172
52regulation of establishment of cell polarity (GO:2000114)3.43520234
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.42858051
54phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.42224656
55vagina development (GO:0060068)3.39755616
56synaptic transmission, glutamatergic (GO:0035249)3.39150192
57regulation of nucleobase-containing compound transport (GO:0032239)3.36146871
58glutamate receptor signaling pathway (GO:0007215)3.36140336
59regulation of ARF protein signal transduction (GO:0032012)3.34470810
60vesicle transport along microtubule (GO:0047496)3.34433881
61embryonic process involved in female pregnancy (GO:0060136)3.33978715
62dendritic spine morphogenesis (GO:0060997)3.32529794
63neuron-neuron synaptic transmission (GO:0007270)3.31221286
64regulation of centriole replication (GO:0046599)3.30622343
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.29826991
66activation of protein kinase A activity (GO:0034199)3.27306139
67regulation of synapse structural plasticity (GO:0051823)3.26316818
68insulin-like growth factor receptor signaling pathway (GO:0048009)3.25991274
69iron ion import (GO:0097286)3.23372749
70embryonic eye morphogenesis (GO:0048048)3.19105957
71neurotransmitter-gated ion channel clustering (GO:0072578)3.18920965
72synaptic vesicle endocytosis (GO:0048488)3.16275314
73positive regulation of insulin receptor signaling pathway (GO:0046628)3.13998880
74regulation of excitatory postsynaptic membrane potential (GO:0060079)3.13986077
75neuromuscular process controlling balance (GO:0050885)3.13691041
76regulation of dendritic spine morphogenesis (GO:0061001)3.13457082
77long-term memory (GO:0007616)3.12702196
78neurotransmitter transport (GO:0006836)3.12400192
79dendrite morphogenesis (GO:0048813)3.11237856
80calcium ion-dependent exocytosis (GO:0017156)3.08400941
81pore complex assembly (GO:0046931)3.08159432
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06585137
83regulation of postsynaptic membrane potential (GO:0060078)3.05451919
84negative regulation of DNA repair (GO:0045738)3.04351545
85positive regulation of membrane potential (GO:0045838)3.02366551
86membrane depolarization during action potential (GO:0086010)3.01448955
87regulation of establishment or maintenance of cell polarity (GO:0032878)3.01366501
88response to peptidoglycan (GO:0032494)3.01320108
89positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00309578
90positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.00189700
91establishment of nucleus localization (GO:0040023)2.99772359
92cellular response to interferon-alpha (GO:0035457)2.95659055
93neuron recognition (GO:0008038)2.95522473
94cytoskeletal anchoring at plasma membrane (GO:0007016)2.94859497
95pre-miRNA processing (GO:0031054)2.94399224
96protein targeting to Golgi (GO:0000042)2.92834095
97peptidyl-threonine dephosphorylation (GO:0035970)2.92666261
98regulation of synaptic plasticity (GO:0048167)2.92079910
99regulation of neurotransmitter secretion (GO:0046928)2.91998931
100positive regulation of cellular response to insulin stimulus (GO:1900078)2.91308885
101focal adhesion assembly (GO:0048041)2.90613142
102cell-substrate adherens junction assembly (GO:0007045)2.90613142
103potassium ion import (GO:0010107)2.89347603
104histone lysine demethylation (GO:0070076)2.87933021
105organelle transport along microtubule (GO:0072384)2.87371460
106positive regulation of synapse maturation (GO:0090129)2.86569675
107cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.86548850
108positive regulation of gamma-delta T cell activation (GO:0046645)2.86001748
109positive regulation of epidermal cell differentiation (GO:0045606)2.85774489
110mating behavior (GO:0007617)2.85543474
111glycine transport (GO:0015816)2.85035501
112negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.83180411
113gamma-aminobutyric acid signaling pathway (GO:0007214)2.83171800
114establishment of protein localization to Golgi (GO:0072600)2.82752573
115axonal fasciculation (GO:0007413)2.82588723
116long-term synaptic potentiation (GO:0060291)2.82531326
117regulation of synaptic transmission, glutamatergic (GO:0051966)2.82303883
118positive regulation of receptor recycling (GO:0001921)2.82120846
119histone H3-K9 demethylation (GO:0033169)2.80759165
120epithelial cell differentiation involved in prostate gland development (GO:0060742)2.80705736
121regulation of neurotransmitter levels (GO:0001505)2.80313533
122negative regulation of inclusion body assembly (GO:0090084)2.79892157
123prepulse inhibition (GO:0060134)2.78348841
124transmission of nerve impulse (GO:0019226)2.77629072
125negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.77536156
126positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.77290676
127neuromuscular process controlling posture (GO:0050884)2.75753083
128intestinal epithelial cell development (GO:0060576)2.74920235
129macrophage activation involved in immune response (GO:0002281)2.74631464
130clathrin coat assembly (GO:0048268)2.73072619
131COPI coating of Golgi vesicle (GO:0048205)2.72405551
132Golgi transport vesicle coating (GO:0048200)2.72405551
133histone demethylation (GO:0016577)2.71691750
134positive regulation of cellular amide metabolic process (GO:0034250)2.70635801
135innervation (GO:0060384)2.69739577
136negative regulation of organelle assembly (GO:1902116)2.69487750
137membrane depolarization (GO:0051899)2.68959290
138membrane hyperpolarization (GO:0060081)2.68907515
139cilium or flagellum-dependent cell motility (GO:0001539)2.68319125
140protein localization to endosome (GO:0036010)2.67798663
141detection of external biotic stimulus (GO:0098581)2.67037416
142regulation of neurotransmitter transport (GO:0051588)2.66104575
143nerve growth factor signaling pathway (GO:0038180)2.65670814
144production of molecular mediator involved in inflammatory response (GO:0002532)2.64994305
145negative regulation of protein localization to plasma membrane (GO:1903077)2.64872809
146L-amino acid import (GO:0043092)2.64556757
147response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64221883
148response to host (GO:0075136)2.64221883
149response to host defenses (GO:0052200)2.64221883
150glucose 6-phosphate metabolic process (GO:0051156)2.61779649
151behavioral response to cocaine (GO:0048148)2.61729677
152positive regulation of neurotransmitter transport (GO:0051590)2.61377274
153auditory behavior (GO:0031223)2.60953167
154protein export from nucleus (GO:0006611)2.60629839
155mitotic sister chromatid cohesion (GO:0007064)2.60250533
156neuromuscular process (GO:0050905)2.59932782
157social behavior (GO:0035176)2.59918198
158intraspecies interaction between organisms (GO:0051703)2.59918198
159response to histamine (GO:0034776)2.58971164
160cell communication by electrical coupling (GO:0010644)2.58928904
161mammary gland epithelial cell proliferation (GO:0033598)2.58895517
162ear development (GO:0043583)2.58055192
163regulation of dendritic spine development (GO:0060998)2.57681265
164macrophage activation (GO:0042116)2.56931254
165negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56073781
166peptidyl-threonine phosphorylation (GO:0018107)2.56010664
167cell migration in hindbrain (GO:0021535)2.55873973
168adherens junction assembly (GO:0034333)2.55627144
169response to auditory stimulus (GO:0010996)2.54835499
170regulation of vesicle fusion (GO:0031338)2.54479292
171definitive hemopoiesis (GO:0060216)2.53449468
172retrograde transport, vesicle recycling within Golgi (GO:0000301)2.53151771
173peptidyl-threonine modification (GO:0018210)2.52308919
174regulation of interferon-beta biosynthetic process (GO:0045357)2.51519735
175response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.51440705
176trophectodermal cell differentiation (GO:0001829)2.51407357
177neutrophil activation involved in immune response (GO:0002283)2.48790884
178dosage compensation (GO:0007549)2.48771233
179negative regulation of erythrocyte differentiation (GO:0045647)2.47723010
180cellular extravasation (GO:0045123)2.47297871
181erythrocyte maturation (GO:0043249)2.47087848
182corticosteroid receptor signaling pathway (GO:0031958)2.44005015
183response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.43403185
184response to host immune response (GO:0052572)2.43403185
185positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.43044522
186negative regulation of focal adhesion assembly (GO:0051895)2.40238443
187negative regulation of cell junction assembly (GO:1901889)2.40238443
188negative regulation of adherens junction organization (GO:1903392)2.40238443
189maternal placenta development (GO:0001893)2.39754084
190branching involved in mammary gland duct morphogenesis (GO:0060444)2.39519726
191intracellular estrogen receptor signaling pathway (GO:0030520)2.37523387
192JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.36003826
193detection of other organism (GO:0098543)2.35996002
194leukocyte aggregation (GO:0070486)2.35737118
195protein demethylation (GO:0006482)2.34031243
196protein dealkylation (GO:0008214)2.34031243
197regulation of NFAT protein import into nucleus (GO:0051532)2.33060112
198chondrocyte development (GO:0002063)2.32933652
199positive regulation of macroautophagy (GO:0016239)2.32441427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.22352549
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.43874281
3ESR1_20079471_ChIP-ChIP_T-47D_Human3.96117494
4E2F7_22180533_ChIP-Seq_HELA_Human3.27476150
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.25596070
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.22653938
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.21881302
8GBX2_23144817_ChIP-Seq_PC3_Human3.04593255
9GATA1_22025678_ChIP-Seq_K562_Human3.01537689
10* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.53976797
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.38435730
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.38176775
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33996759
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32797756
15DROSHA_22980978_ChIP-Seq_HELA_Human2.31132966
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25014341
17TCF7_22412390_ChIP-Seq_EML_Mouse2.22023933
18REST_21632747_ChIP-Seq_MESCs_Mouse2.20268139
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.17606708
20MYC_22102868_ChIP-Seq_BL_Human2.17518146
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15569071
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12948288
23ESR1_15608294_ChIP-ChIP_MCF-7_Human2.05809606
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05219467
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03701970
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03172968
27PKCTHETA_26484144_Chip-Seq_BREAST_Human1.96608489
28* RUNX1_27514584_Chip-Seq_MCF-7_Human1.96144276
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.94850289
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.94850289
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.92611639
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90588592
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90231579
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87018724
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85594784
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84506547
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79209525
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.76203458
39* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.75780113
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74349981
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.74256688
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73879298
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73531733
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72923351
45SCL_19346495_ChIP-Seq_HPC-7_Human1.71858399
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70443405
47SMAD4_21799915_ChIP-Seq_A2780_Human1.69579308
48* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69469693
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.69435401
50AR_21572438_ChIP-Seq_LNCaP_Human1.66846664
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66272689
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65934475
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.65066930
54RACK7_27058665_Chip-Seq_MCF-7_Human1.64345595
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63473536
56CLOCK_20551151_ChIP-Seq_293T_Human1.60321623
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59630900
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.58685400
59VDR_21846776_ChIP-Seq_THP-1_Human1.57584365
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56888671
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.56176773
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54427354
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.54211885
64TAF15_26573619_Chip-Seq_HEK293_Human1.50358009
65SPI1_23127762_ChIP-Seq_K562_Human1.50285569
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.48700463
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48186908
68ZNF274_21170338_ChIP-Seq_K562_Hela1.48013717
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.45885433
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45431280
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45123270
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44009613
73IRF8_27001747_Chip-Seq_BMDM_Mouse1.43177099
74* STAT3_23295773_ChIP-Seq_U87_Human1.43056831
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.40631794
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40060644
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39457927
78KDM2B_26808549_Chip-Seq_DND41_Human1.38132439
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37163800
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.36562062
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35985362
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35396234
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35212572
84* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35033008
85* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34673399
86GATA3_24758297_ChIP-Seq_MCF-7_Human1.34409073
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33753352
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33753352
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33420590
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33201594
91VDR_24763502_ChIP-Seq_THP-1_Human1.32108998
92* TFEB_21752829_ChIP-Seq_HELA_Human1.31251087
93* PU_27001747_Chip-Seq_BMDM_Mouse1.30658707
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29680694
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28654139
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.28413713
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27731830
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26515167
99ZNF263_19887448_ChIP-Seq_K562_Human1.26162155
100* TCF4_23295773_ChIP-Seq_U87_Human1.25518422
101* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25115049
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24132142
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24064491
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23903273
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23734930
106RUNX1_22412390_ChIP-Seq_EML_Mouse1.22936871
107RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22713340
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.21982821
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21603276
110P300_19829295_ChIP-Seq_ESCs_Human1.20839530
111* AR_19668381_ChIP-Seq_PC3_Human1.20722803
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.20448009
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19827177
114TP53_16413492_ChIP-PET_HCT116_Human1.19289277
115AR_25329375_ChIP-Seq_VCAP_Human1.18930546
116* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18597123
117NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18128952
118SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18083646
119MAF_26560356_Chip-Seq_TH1_Human1.18066732
120GATA2_19941826_ChIP-Seq_K562_Human1.17990692
121AHR_22903824_ChIP-Seq_MCF-7_Human1.16690775
122KDM2B_26808549_Chip-Seq_K562_Human1.16490766
123* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16470342
124ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16454293
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16345906
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16254055
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15918723
128* SPI1_23547873_ChIP-Seq_NB4_Human1.15741884
129FOXO3_23340844_ChIP-Seq_DLD1_Human1.15082551
130GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14653801
131POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12431050
132ERG_21242973_ChIP-ChIP_JURKAT_Human1.12428481
133* STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11954742
134CHD1_26751641_Chip-Seq_LNCaP_Human1.11673539
135ELK3_25401928_ChIP-Seq_HUVEC_Human1.11649155
136* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11613629
137STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11597518
138SALL1_21062744_ChIP-ChIP_HESCs_Human1.11324943
139YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11073228
140NCOR1_26117541_ChIP-Seq_K562_Human1.11038500
141* ER_23166858_ChIP-Seq_MCF-7_Human1.10512424
142RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09684040
143TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09573860
144SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09376008
145P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08198087
146* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07813939
147SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07648326
148TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07605120
149TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07205226
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06436043
151* MYB_26560356_Chip-Seq_TH1_Human1.06384906
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06295149
153KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04567645
154KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04567645
155KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04567645
156* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04430911
157ATF3_27146783_Chip-Seq_COLON_Human1.03885734
158DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03737904
159GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02892113
160IRF8_21731497_ChIP-ChIP_J774_Mouse1.02564768
161TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02440786
162NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02024962
163GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01922390
164SMAD3_21741376_ChIP-Seq_ESCs_Human1.01872722
165MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01805936
166KDM2B_26808549_Chip-Seq_JURKAT_Human1.00127581
167VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99634467
168SMAD3_21741376_ChIP-Seq_HESCs_Human0.98998009
169P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98818535
170BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98171262
171BCAT_22108803_ChIP-Seq_LS180_Human0.96998799
172SMAD4_21741376_ChIP-Seq_HESCs_Human0.96951913
173WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96734335
174* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96330194
175* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96154476
176GATA1_19941826_ChIP-Seq_K562_Human0.95392253
177RING1B_27294783_Chip-Seq_ESCs_Mouse0.94751113
178SMAD4_21741376_ChIP-Seq_EPCs_Human0.93487043
179GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93359001
180ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93209343
181IGF1R_20145208_ChIP-Seq_DFB_Human0.92580161
182KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92309730
183TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91751433
184CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90323150
185RUNX2_22187159_ChIP-Seq_PCA_Human0.90296339
186MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89382330
187EP300_21415370_ChIP-Seq_HL-1_Mouse0.86878506
188RXR_22108803_ChIP-Seq_LS180_Human0.86829115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.38670049
2MP0003705_abnormal_hypodermis_morpholog4.07082787
3MP0004270_analgesia4.01534950
4MP0003880_abnormal_central_pattern3.95746788
5MP0003635_abnormal_synaptic_transmissio3.90103954
6MP0005076_abnormal_cell_differentiation3.62317776
7MP0009046_muscle_twitch3.38642378
8MP0008260_abnormal_autophagy3.32927403
9MP0005451_abnormal_body_composition3.27174859
10MP0002063_abnormal_learning/memory/cond3.09852572
11MP0009745_abnormal_behavioral_response3.09005769
12MP0002064_seizures2.97639277
13MP0002877_abnormal_melanocyte_morpholog2.95535341
14MP0001968_abnormal_touch/_nociception2.86069701
15MP0008057_abnormal_DNA_replication2.82790582
16MP0004381_abnormal_hair_follicle2.74480323
17MP0002734_abnormal_mechanical_nocicepti2.64995051
18MP0003191_abnormal_cellular_cholesterol2.64262393
19MP0004264_abnormal_extraembryonic_tissu2.62944002
20MP0002822_catalepsy2.53560604
21MP0002572_abnormal_emotion/affect_behav2.52408390
22MP0001486_abnormal_startle_reflex2.43729429
23MP0002272_abnormal_nervous_system2.42652426
24MP0005410_abnormal_fertilization2.33061209
25MP0005423_abnormal_somatic_nervous2.32931452
26MP0000569_abnormal_digit_pigmentation2.29787001
27MP0002735_abnormal_chemical_nociception2.18456970
28MP0003329_amyloid_beta_deposits2.17551706
29MP0002796_impaired_skin_barrier2.13151555
30MP0009780_abnormal_chondrocyte_physiolo2.10200592
31MP0001440_abnormal_grooming_behavior2.04500526
32MP0003566_abnormal_cell_adhesion2.04021907
33MP0010352_gastrointestinal_tract_polyps2.03597253
34MP0002009_preneoplasia1.99037532
35MP0002736_abnormal_nociception_after1.97140986
36MP0002733_abnormal_thermal_nociception1.96633928
37MP0005409_darkened_coat_color1.96388741
38MP0001501_abnormal_sleep_pattern1.96172613
39MP0002067_abnormal_sensory_capabilities1.90395328
40MP0004185_abnormal_adipocyte_glucose1.88322243
41MP0004811_abnormal_neuron_physiology1.88005946
42MP0003787_abnormal_imprinting1.82563051
43MP0008569_lethality_at_weaning1.80566035
44MP0004808_abnormal_hematopoietic_stem1.77990679
45MP0001970_abnormal_pain_threshold1.73673440
46MP0002396_abnormal_hematopoietic_system1.70807176
47MP0000383_abnormal_hair_follicle1.70627873
48MP0000778_abnormal_nervous_system1.69012708
49MP0005386_behavior/neurological_phenoty1.66911975
50MP0004924_abnormal_behavior1.66911975
51MP0010678_abnormal_skin_adnexa1.66555425
52MP0004885_abnormal_endolymph1.63745554
53MP0004858_abnormal_nervous_system1.62510842
54MP0002909_abnormal_adrenal_gland1.61920636
55MP0005408_hypopigmentation1.60969796
56MP0004147_increased_porphyrin_level1.59389054
57MP0002166_altered_tumor_susceptibility1.58519813
58MP0008877_abnormal_DNA_methylation1.52894691
59MP0003221_abnormal_cardiomyocyte_apopto1.52036318
60MP0005623_abnormal_meninges_morphology1.51078206
61MP0003879_abnormal_hair_cell1.50919037
62MP0000955_abnormal_spinal_cord1.50912659
63MP0003633_abnormal_nervous_system1.50663775
64MP0002557_abnormal_social/conspecific_i1.50093671
65MP0003453_abnormal_keratinocyte_physiol1.48884539
66MP0002184_abnormal_innervation1.47674190
67MP0003303_peritoneal_inflammation1.45922878
68MP0010307_abnormal_tumor_latency1.45182319
69MP0003656_abnormal_erythrocyte_physiolo1.42930633
70MP0002332_abnormal_exercise_endurance1.41812940
71MP0002882_abnormal_neuron_morphology1.40838895
72MP0005058_abnormal_lysosome_morphology1.37539160
73MP0003631_nervous_system_phenotype1.36528649
74MP0003300_gastrointestinal_ulcer1.34919406
75MP0000427_abnormal_hair_cycle1.34614025
76MP0003828_pulmonary_edema1.33768852
77MP0001984_abnormal_olfaction1.32855281
78MP0002066_abnormal_motor_capabilities/c1.31887950
79MP0010234_abnormal_vibrissa_follicle1.31500862
80MP0003091_abnormal_cell_migration1.31242818
81MP0005501_abnormal_skin_physiology1.30456351
82MP0009672_abnormal_birth_weight1.29425856
83MP0009278_abnormal_bone_marrow1.29387561
84MP0004947_skin_inflammation1.29147082
85MP0005551_abnormal_eye_electrophysiolog1.28939473
86MP0005621_abnormal_cell_physiology1.28933018
87MP0005075_abnormal_melanosome_morpholog1.27867807
88MP0001849_ear_inflammation1.26564840
89MP0000371_diluted_coat_color1.25963806
90MP0000377_abnormal_hair_follicle1.22435191
91MP0002229_neurodegeneration1.20536159
92MP0000920_abnormal_myelination1.17399081
93MP0005397_hematopoietic_system_phenotyp1.17193378
94MP0001545_abnormal_hematopoietic_system1.17193378
95MP0003690_abnormal_glial_cell1.16976992
96MP0003632_abnormal_nervous_system1.16285698
97MP0000858_altered_metastatic_potential1.15413128
98MP0005646_abnormal_pituitary_gland1.15061310
99MP0003698_abnormal_male_reproductive1.13817542
100MP0006276_abnormal_autonomic_nervous1.13372140
101MP0000627_abnormal_mammary_gland1.13161411
102MP0004883_abnormal_blood_vessel1.12986233
103MP0000604_amyloidosis1.12808144
104MP0002086_abnormal_extraembryonic_tissu1.10815973
105MP0002152_abnormal_brain_morphology1.09880588
106MP0000015_abnormal_ear_pigmentation1.08878559
107MP0003183_abnormal_peptide_metabolism1.06659344
108MP0008961_abnormal_basal_metabolism1.05827353
109MP0003634_abnormal_glial_cell1.04359669
110MP0001835_abnormal_antigen_presentation1.03790770
111MP0003941_abnormal_skin_development1.02281585
112MP0002060_abnormal_skin_morphology1.02236055
113MP0002088_abnormal_embryonic_growth/wei1.02190146
114MP0003984_embryonic_growth_retardation1.00867515
115MP0003122_maternal_imprinting1.00681945
116MP0003045_fibrosis1.00532633
117MP0001502_abnormal_circadian_rhythm0.99726588
118MP0003436_decreased_susceptibility_to0.99110147
119MP0005464_abnormal_platelet_physiology0.98586212
120MP0002419_abnormal_innate_immunity0.98135809
121MP0002090_abnormal_vision0.98075518
122MP0004742_abnormal_vestibular_system0.97525397
123MP0003724_increased_susceptibility_to0.96478603
124MP0005384_cellular_phenotype0.96322744
125MP0001915_intracranial_hemorrhage0.95751442
126MP0001177_atelectasis0.94697457
127MP0009115_abnormal_fat_cell0.94249621
128MP0005083_abnormal_biliary_tract0.94065626
129MP0001672_abnormal_embryogenesis/_devel0.92596584
130MP0005380_embryogenesis_phenotype0.92596584
131MP0008874_decreased_physiological_sensi0.92375438
132MP0002006_tumorigenesis0.92155427
133MP0000350_abnormal_cell_proliferation0.92135243
134MP0008872_abnormal_physiological_respon0.92089310
135MP0004142_abnormal_muscle_tone0.91576649
136MP0000703_abnormal_thymus_morphology0.90337556
137MP0005535_abnormal_body_temperature0.89163895
138MP0002998_abnormal_bone_remodeling0.88052915
139MP0003866_abnormal_defecation0.87714514
140MP0001697_abnormal_embryo_size0.87651955
141MP0002098_abnormal_vibrissa_morphology0.87323834
142MP0001730_embryonic_growth_arrest0.84393663
143MP0003763_abnormal_thymus_physiology0.83896748
144MP0010630_abnormal_cardiac_muscle0.83775361
145MP0001299_abnormal_eye_distance/0.83717440
146MP0009703_decreased_birth_body0.83500275
147MP0001851_eye_inflammation0.83498457
148MP0004085_abnormal_heartbeat0.82472782
149MP0002398_abnormal_bone_marrow0.82450312
150MP0000462_abnormal_digestive_system0.81168270
151MP0003115_abnormal_respiratory_system0.81061465
152MP0004957_abnormal_blastocyst_morpholog0.80423654
153MP0005167_abnormal_blood-brain_barrier0.80024451
154MP0001348_abnormal_lacrimal_gland0.79926471
155MP0002722_abnormal_immune_system0.79484303
156MP0009931_abnormal_skin_appearance0.79068657
157MP0001186_pigmentation_phenotype0.78766240
158MP0002080_prenatal_lethality0.78339107
159MP0001216_abnormal_epidermal_layer0.77311040
160MP0005248_abnormal_Harderian_gland0.77159916
161MP0004233_abnormal_muscle_weight0.76498772
162MP0002069_abnormal_eating/drinking_beha0.75497167
163MP0004130_abnormal_muscle_cell0.73975923
164MP0003075_altered_response_to0.73684202
165MP0003123_paternal_imprinting0.73320471
166MP0005645_abnormal_hypothalamus_physiol0.73291378
167MP0004782_abnormal_surfactant_physiolog0.72945189
168MP0005666_abnormal_adipose_tissue0.71513984
169MP0005164_abnormal_response_to0.70704340
170MP0000751_myopathy0.70085608
171MP0001929_abnormal_gametogenesis0.68619832
172MP0001905_abnormal_dopamine_level0.67826473
173MP0002837_dystrophic_cardiac_calcinosis0.66804842
174MP0005187_abnormal_penis_morphology0.65512333
175MP0003283_abnormal_digestive_organ0.64578319
176MP0002752_abnormal_somatic_nervous0.64361074
177MP0001963_abnormal_hearing_physiology0.63395187
178MP0002653_abnormal_ependyma_morphology0.63226751
179MP0002161_abnormal_fertility/fecundity0.61332006
180MP0004484_altered_response_of0.60303381
181MP0000013_abnormal_adipose_tissue0.58788990
182MP0001529_abnormal_vocalization0.58169035
183MP0003172_abnormal_lysosome_physiology0.57605406
184MP0003861_abnormal_nervous_system0.57249239
185MP0004215_abnormal_myocardial_fiber0.52436564
186MP0010769_abnormal_survival0.51435377
187MP0001943_abnormal_respiration0.50689264
188MP0010770_preweaning_lethality0.49092476
189MP0002082_postnatal_lethality0.49092476
190MP0000747_muscle_weakness0.48516327

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.86053679
2Myokymia (HP:0002411)5.20012182
3Focal seizures (HP:0007359)4.92067117
4Absent frontal sinuses (HP:0002688)4.50994799
5Asymmetry of the thorax (HP:0001555)4.30264054
6Visual hallucinations (HP:0002367)4.14796255
7Action tremor (HP:0002345)4.00493700
8J-shaped sella turcica (HP:0002680)3.93082134
9Epileptic encephalopathy (HP:0200134)3.92874093
10Progressive cerebellar ataxia (HP:0002073)3.85559001
11Micronodular cirrhosis (HP:0001413)3.69941264
12Atonic seizures (HP:0010819)3.69676375
13Febrile seizures (HP:0002373)3.61441220
14Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.49218070
15Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.45961377
16Generalized tonic-clonic seizures (HP:0002069)3.42666207
17Abnormality of the lower motor neuron (HP:0002366)3.40719964
18Absence seizures (HP:0002121)3.35893972
19Gaze-evoked nystagmus (HP:0000640)3.26835452
20Urinary bladder sphincter dysfunction (HP:0002839)3.24980577
21Impaired vibration sensation in the lower limbs (HP:0002166)3.23304724
22Supranuclear gaze palsy (HP:0000605)3.20382711
23Termporal pattern (HP:0011008)3.19864174
24Insidious onset (HP:0003587)3.19864174
25Postural instability (HP:0002172)3.19621811
26Ankle clonus (HP:0011448)3.17425979
27Subacute progressive viral hepatitis (HP:0006572)3.14336389
28Absent/shortened dynein arms (HP:0200106)3.13013035
29Dynein arm defect of respiratory motile cilia (HP:0012255)3.13013035
30Syringomyelia (HP:0003396)3.08386659
31Spinal cord lesions (HP:0100561)3.08386659
32Depression (HP:0000716)3.07099869
33Dysdiadochokinesis (HP:0002075)3.05356083
34Dialeptic seizures (HP:0011146)3.04884393
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.02657120
36Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.02501012
37Urinary urgency (HP:0000012)2.99363305
38Truncal ataxia (HP:0002078)2.90841016
39Deformed sella turcica (HP:0002681)2.86992544
40Abnormality of the frontal sinuses (HP:0002687)2.84681792
41Thyroid carcinoma (HP:0002890)2.84080202
42Abnormal social behavior (HP:0012433)2.78807189
43Impaired social interactions (HP:0000735)2.78807189
44Abnormality of the corticospinal tract (HP:0002492)2.78781203
45Dysmetria (HP:0001310)2.77353011
46Microglossia (HP:0000171)2.77345897
47Esophageal varix (HP:0002040)2.76753606
48Spastic gait (HP:0002064)2.71523305
49Intention tremor (HP:0002080)2.71351753
50Deep philtrum (HP:0002002)2.70102457
51Poor eye contact (HP:0000817)2.67896007
52Cerebral inclusion bodies (HP:0100314)2.67685844
53Broad-based gait (HP:0002136)2.64429497
54Genetic anticipation (HP:0003743)2.61400845
55Insomnia (HP:0100785)2.60602855
56Germ cell neoplasia (HP:0100728)2.57243176
57Poikilocytosis (HP:0004447)2.53998942
58Recurrent abscess formation (HP:0002722)2.53859252
59Dysmetric saccades (HP:0000641)2.51263031
60Abnormality of ocular smooth pursuit (HP:0000617)2.50687199
61Hemiparesis (HP:0001269)2.50362139
62Scanning speech (HP:0002168)2.48399173
63Papilledema (HP:0001085)2.47421208
64Recurrent bacterial skin infections (HP:0005406)2.46986860
65Neurofibrillary tangles (HP:0002185)2.46810117
66Drooling (HP:0002307)2.45470961
67Excessive salivation (HP:0003781)2.45470961
68Hyperventilation (HP:0002883)2.44439147
69Lower limb muscle weakness (HP:0007340)2.42621906
70Impaired smooth pursuit (HP:0007772)2.41681546
71Curly hair (HP:0002212)2.41580508
72Macroorchidism (HP:0000053)2.40588229
73Impaired vibratory sensation (HP:0002495)2.36328048
74Uterine leiomyosarcoma (HP:0002891)2.34869711
75Leiomyosarcoma (HP:0100243)2.34869711
76Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.34788365
77Anxiety (HP:0000739)2.33688452
78Resting tremor (HP:0002322)2.31166442
79Progressive inability to walk (HP:0002505)2.30920939
80Hyperacusis (HP:0010780)2.30867510
81Slow saccadic eye movements (HP:0000514)2.29667601
82Absent speech (HP:0001344)2.29142810
83Bradykinesia (HP:0002067)2.29050591
84Amyotrophic lateral sclerosis (HP:0007354)2.28878798
85Eczematoid dermatitis (HP:0000976)2.27656434
86Mutism (HP:0002300)2.25935016
87Transitional cell carcinoma of the bladder (HP:0006740)2.23981265
88Abnormal respiratory motile cilium physiology (HP:0012261)2.19175212
89Bladder carcinoma (HP:0002862)2.18444572
90Bladder neoplasm (HP:0009725)2.18444572
91Status epilepticus (HP:0002133)2.18154926
92Amblyopia (HP:0000646)2.17745451
93Nephroblastoma (Wilms tumor) (HP:0002667)2.17595244
94Acanthocytosis (HP:0001927)2.17414032
95Abnormality of the sella turcica (HP:0002679)2.16703653
96Testicular neoplasm (HP:0010788)2.16645023
97Breast carcinoma (HP:0003002)2.15289252
98Osteolytic defects of the phalanges of the hand (HP:0009771)2.13793878
99Osteolytic defects of the hand bones (HP:0009699)2.13793878
100Abnormal eating behavior (HP:0100738)2.13566161
101Spastic tetraparesis (HP:0001285)2.13296993
102Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.13124365
103Degeneration of the lateral corticospinal tracts (HP:0002314)2.13124365
104Clonus (HP:0002169)2.12452331
105Hypopigmentation of the fundus (HP:0007894)2.10314306
106Hemiplegia (HP:0002301)2.09453134
107Ventricular fibrillation (HP:0001663)2.09117739
108Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08427307
109Reticulocytosis (HP:0001923)2.08290369
110Gastrointestinal carcinoma (HP:0002672)2.07597802
111Malignant gastrointestinal tract tumors (HP:0006749)2.07597802
112Viral hepatitis (HP:0006562)2.06054453
113Diplopia (HP:0000651)2.05311808
114Abnormality of binocular vision (HP:0011514)2.05311808
115Abnormality of the fingertips (HP:0001211)2.04703723
116Heterotopia (HP:0002282)2.02815462
117Embryonal renal neoplasm (HP:0011794)2.01792621
118Renal cell carcinoma (HP:0005584)2.01600977
119Arterial thrombosis (HP:0004420)1.99482194
120Gingivitis (HP:0000230)1.99465938
121Torticollis (HP:0000473)1.98241599
122Pheochromocytoma (HP:0002666)1.97910881
123Septate vagina (HP:0001153)1.97342039
124Hypochromic microcytic anemia (HP:0004840)1.97049251
125Infertility (HP:0000789)1.96995267
126Chromsome breakage (HP:0040012)1.95215232
127Central scotoma (HP:0000603)1.94530028
128Epileptiform EEG discharges (HP:0011182)1.94306651
129Hyporeflexia of lower limbs (HP:0002600)1.93014731
130Rhinitis (HP:0012384)1.92562828
131Acute myeloid leukemia (HP:0004808)1.92450597
132Gait ataxia (HP:0002066)1.92168742
133Sparse lateral eyebrow (HP:0005338)1.91848285
134Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91300224
135Lower limb amyotrophy (HP:0007210)1.90083372
136EEG with generalized epileptiform discharges (HP:0011198)1.88972322
137Megalencephaly (HP:0001355)1.88198898
138Neuronal loss in central nervous system (HP:0002529)1.88193889
139Inappropriate behavior (HP:0000719)1.87273141
140Flat acetabular roof (HP:0003180)1.87105282
141Blue irides (HP:0000635)1.86515249
142Decreased motor nerve conduction velocity (HP:0003431)1.86215479
143Distal lower limb muscle weakness (HP:0009053)1.85860021
144Fatigue (HP:0012378)1.85445957
145Abnormality of saccadic eye movements (HP:0000570)1.85164459
146Arterial tortuosity (HP:0005116)1.84394676
147Neoplasm of the thyroid gland (HP:0100031)1.84042960
148Menstrual irregularities (HP:0000858)1.83882140
149Increased connective tissue (HP:0009025)1.82313908
150Hypsarrhythmia (HP:0002521)1.81850913
151Peritonitis (HP:0002586)1.81261617
152Long toe (HP:0010511)1.80975558
153Cutaneous melanoma (HP:0012056)1.79279282
154Global brain atrophy (HP:0002283)1.77605747
155Onion bulb formation (HP:0003383)1.77461560
156Gingival bleeding (HP:0000225)1.76873533
157Stereotypic behavior (HP:0000733)1.75724834
158Neonatal hypoglycemia (HP:0001998)1.75249039
159Clumsiness (HP:0002312)1.74432476
160Myocardial infarction (HP:0001658)1.73796049
161Aqueductal stenosis (HP:0002410)1.72523809
162Papillary thyroid carcinoma (HP:0002895)1.72357031
163Broad face (HP:0000283)1.72339259
164Abnormality of macrophages (HP:0004311)1.72239597
165Coarse hair (HP:0002208)1.70377247
166Ankyloglossia (HP:0010296)1.69529583
167Bundle branch block (HP:0011710)1.68944403
168Abnormal ciliary motility (HP:0012262)1.68289699
169Hammertoe (HP:0001765)1.68277011
170T lymphocytopenia (HP:0005403)1.67462858
171Gastrointestinal infarctions (HP:0005244)1.65640350
172Abnormality of oral frenula (HP:0000190)1.57976218
173Cerebral aneurysm (HP:0004944)1.57446620
174Vascular tortuosity (HP:0004948)1.56972296
175Distal lower limb amyotrophy (HP:0008944)1.56542779
176Periodontitis (HP:0000704)1.56367401
177Difficulty running (HP:0009046)1.55779411
178Metaphyseal cupping (HP:0003021)1.55172797
179Cellulitis (HP:0100658)1.54842034
180Cystic hygroma (HP:0000476)1.54315637
181Abnormality of the distal phalanx of the thumb (HP:0009617)1.53825515
182Orthostatic hypotension (HP:0001278)1.53274234
183Abnormality of the radial head (HP:0003995)1.52368794
184Patellar dislocation (HP:0002999)1.52314449
185Vertebral arch anomaly (HP:0008438)1.51553289
186Dislocated radial head (HP:0003083)1.51307021
187Abnormality of nail color (HP:0100643)1.50355743
188Cranial hyperostosis (HP:0004437)1.48610414
189Relative macrocephaly (HP:0004482)1.47435072
190Orchitis (HP:0100796)1.47118545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.33942563
2NTRK33.97921926
3MAP3K93.74902585
4EPHA43.40549689
5MAP3K43.19059142
6SIK12.80909501
7PKN22.72275470
8RPS6KB22.68252068
9PRKD32.61011667
10MARK12.56410709
11PIK3CA2.48617535
12NEK62.31425748
13MINK12.28660978
14MAP2K72.26240794
15SMG12.25652775
16DAPK22.20255992
17PAK62.15464047
18FGFR42.03569768
19KSR22.02788510
20MAP2K42.01201525
21MAP2K31.99953438
22NTRK11.93892784
23PDK31.89468227
24PDK41.89468227
25EEF2K1.87484461
26CAMKK11.83941582
27NTRK21.71473662
28TTN1.57218330
29STK381.55599886
30TYRO31.54216518
31PNCK1.52631043
32RIPK41.47955575
33KSR11.46469527
34CDK51.42866436
35EIF2AK11.40302026
36IRAK31.38373430
37CAMK1G1.37644448
38WNK11.37430684
39RET1.31115195
40IRAK41.29547474
41GRK51.23131328
42FGFR31.22640519
43STK391.22441674
44PTK2B1.22315071
45MAP3K21.22128434
46MAP3K101.21420670
47GRK61.21047612
48MTOR1.17961893
49YES11.16418821
50CHUK1.15352428
51SGK2231.15084021
52SGK4941.15084021
53BRD41.13970072
54SCYL21.13791167
55PTK61.11279960
56PDGFRA1.10472922
57RIPK11.09786752
58RPS6KB11.06872998
59PLK21.06703478
60SGK31.06294725
61IKBKE1.05810734
62JAK11.05033202
63WNK41.03675096
64MAP2K21.01088569
65STK110.99155723
66PRPF4B0.98481300
67SGK20.97331090
68PDK10.96340702
69PDK20.96165836
70MAP3K140.96045352
71CSF1R0.95747811
72PRKCH0.94900980
73BMPR20.93974167
74MAP3K30.93350218
75MAP3K130.92922992
76MAPK130.91926655
77ICK0.91070045
78SIK30.89701609
79OXSR10.89367193
80MAP3K120.89055162
81EPHB10.88019073
82SIK20.87597349
83FES0.87152356
84SGK10.87120590
85LMTK20.86803629
86DAPK10.86300450
87IRAK20.85857953
88PRKCG0.85750373
89TRPM70.85230456
90FGFR20.84310872
91CASK0.84001970
92CDK120.83024665
93LATS20.82936232
94CSK0.82314244
95JAK20.82174376
96CAMKK20.82130207
97MELK0.80629415
98CSNK1G20.80524606
99CDK60.79683248
100PAK30.79217743
101LRRK20.78897125
102CLK10.78011230
103TAOK10.77313539
104TNIK0.76732918
105CAMK2A0.76176247
106JAK30.74629670
107PDPK10.74581222
108CAMK1D0.74572213
109PAK40.73868778
110MUSK0.73166189
111TYK20.73071050
112BLK0.70904936
113RPS6KA20.70687761
114PHKG20.70411707
115PHKG10.70411707
116ALK0.69174300
117STK40.67958698
118CDK140.67052475
119CDK150.66827135
120FER0.66741488
121CDK180.66372199
122ERN10.65391263
123UHMK10.63857005
124CDK190.63667350
125CAMK10.62077604
126FRK0.60050113
127MAP3K60.59529875
128RPS6KA30.57502021
129FGR0.54366384
130CDC42BPA0.54337391
131PRKCZ0.53216368
132CDK11A0.53178984
133DYRK1A0.52928946
134CDK70.51682380
135MAPKAPK30.51623669
136MAP3K10.51069510
137MAPK100.49761981
138WNK30.49641963
139MAPKAPK20.49519836
140MARK20.49297384
141CAMK2B0.49201747
142TNK20.49196013
143TAOK20.47862465
144MAP3K70.46940813
145HCK0.46525925
146PKN10.45930789
147DMPK0.45825688
148PRKAA10.45822126
149FYN0.43867377
150PTK20.43621053
151PDGFRB0.42914909
152BMX0.42705805
153PIK3CG0.42615424
154ARAF0.41959180
155RPS6KL10.41772102
156RPS6KC10.41772102
157BTK0.41154512
158MAP2K10.37852572
159CSNK1D0.37620679
160RAF10.37613059
161IRAK10.37603701
162TBK10.37472989
163EPHA20.36550237

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.89671039
2Nicotine addiction_Homo sapiens_hsa050332.68114132
3Long-term potentiation_Homo sapiens_hsa047202.35851980
4Acute myeloid leukemia_Homo sapiens_hsa052212.33389385
5Olfactory transduction_Homo sapiens_hsa047402.31765860
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.30278713
7GABAergic synapse_Homo sapiens_hsa047272.24648844
8Thyroid cancer_Homo sapiens_hsa052162.23724910
9Circadian entrainment_Homo sapiens_hsa047132.23724536
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22619297
11Chronic myeloid leukemia_Homo sapiens_hsa052202.12069713
12Glutamatergic synapse_Homo sapiens_hsa047242.10811479
13Amphetamine addiction_Homo sapiens_hsa050312.09073730
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07787438
15Morphine addiction_Homo sapiens_hsa050322.02963908
16Nitrogen metabolism_Homo sapiens_hsa009101.92808953
17Dopaminergic synapse_Homo sapiens_hsa047281.90924937
18Salivary secretion_Homo sapiens_hsa049701.90783479
19B cell receptor signaling pathway_Homo sapiens_hsa046621.79360277
20Gastric acid secretion_Homo sapiens_hsa049711.75848172
21Dorso-ventral axis formation_Homo sapiens_hsa043201.73671307
22Insulin secretion_Homo sapiens_hsa049111.73547763
23Pancreatic cancer_Homo sapiens_hsa052121.69504019
24Cholinergic synapse_Homo sapiens_hsa047251.61525933
25Renin secretion_Homo sapiens_hsa049241.60716390
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59426713
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48492257
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47913876
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45539826
30Oxytocin signaling pathway_Homo sapiens_hsa049211.43037632
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42813581
32Long-term depression_Homo sapiens_hsa047301.42120084
33Prostate cancer_Homo sapiens_hsa052151.36711674
34Cocaine addiction_Homo sapiens_hsa050301.36567182
35Osteoclast differentiation_Homo sapiens_hsa043801.34471340
36Type II diabetes mellitus_Homo sapiens_hsa049301.33614513
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32863913
38Taste transduction_Homo sapiens_hsa047421.31879901
39Hepatitis C_Homo sapiens_hsa051601.31762903
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29852093
41Bladder cancer_Homo sapiens_hsa052191.28982482
42Serotonergic synapse_Homo sapiens_hsa047261.28711673
43Collecting duct acid secretion_Homo sapiens_hsa049661.28587162
44Hepatitis B_Homo sapiens_hsa051611.28039165
45GnRH signaling pathway_Homo sapiens_hsa049121.27400424
46Estrogen signaling pathway_Homo sapiens_hsa049151.24107173
47Glioma_Homo sapiens_hsa052141.23268454
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21251800
49Calcium signaling pathway_Homo sapiens_hsa040201.19874513
50Proteoglycans in cancer_Homo sapiens_hsa052051.19767793
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18954162
52Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18596871
53Gap junction_Homo sapiens_hsa045401.17774987
54cAMP signaling pathway_Homo sapiens_hsa040241.15566324
55FoxO signaling pathway_Homo sapiens_hsa040681.12476066
56MicroRNAs in cancer_Homo sapiens_hsa052061.12297940
57Adherens junction_Homo sapiens_hsa045201.10802311
58HIF-1 signaling pathway_Homo sapiens_hsa040661.10607935
59Insulin resistance_Homo sapiens_hsa049311.10464258
60Colorectal cancer_Homo sapiens_hsa052101.09815732
61ErbB signaling pathway_Homo sapiens_hsa040121.09565558
62Measles_Homo sapiens_hsa051621.09396437
63Leukocyte transendothelial migration_Homo sapiens_hsa046701.09048628
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07032439
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05965529
66Phototransduction_Homo sapiens_hsa047441.05955641
67Leishmaniasis_Homo sapiens_hsa051401.04235803
68T cell receptor signaling pathway_Homo sapiens_hsa046601.03985368
69Small cell lung cancer_Homo sapiens_hsa052221.03485208
70Axon guidance_Homo sapiens_hsa043601.02220256
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99353298
72Platelet activation_Homo sapiens_hsa046110.98950708
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97868956
74Legionellosis_Homo sapiens_hsa051340.96675129
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96203629
76Influenza A_Homo sapiens_hsa051640.95015707
77Pentose phosphate pathway_Homo sapiens_hsa000300.93488417
78Viral carcinogenesis_Homo sapiens_hsa052030.93425766
79Apoptosis_Homo sapiens_hsa042100.93036749
80Oocyte meiosis_Homo sapiens_hsa041140.88631820
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.87970436
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87317610
83Tuberculosis_Homo sapiens_hsa051520.86539996
84Amoebiasis_Homo sapiens_hsa051460.85948355
85Melanogenesis_Homo sapiens_hsa049160.85122768
86Melanoma_Homo sapiens_hsa052180.84957538
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84760642
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.84382627
89Glucagon signaling pathway_Homo sapiens_hsa049220.84361690
90Alcoholism_Homo sapiens_hsa050340.82109103
91Thyroid hormone synthesis_Homo sapiens_hsa049180.81972334
92Bile secretion_Homo sapiens_hsa049760.81578709
93Toxoplasmosis_Homo sapiens_hsa051450.79933678
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.79921320
95Choline metabolism in cancer_Homo sapiens_hsa052310.79404617
96mTOR signaling pathway_Homo sapiens_hsa041500.78831680
97Focal adhesion_Homo sapiens_hsa045100.78646534
98Other glycan degradation_Homo sapiens_hsa005110.77746410
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76780603
100TNF signaling pathway_Homo sapiens_hsa046680.75900563
101Pancreatic secretion_Homo sapiens_hsa049720.73586249
102MAPK signaling pathway_Homo sapiens_hsa040100.73301951
103Inositol phosphate metabolism_Homo sapiens_hsa005620.73264592
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72199148
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.72151744
106Notch signaling pathway_Homo sapiens_hsa043300.71980168
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69767995
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69213598
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68723796
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.68704475
111Shigellosis_Homo sapiens_hsa051310.68319411
112VEGF signaling pathway_Homo sapiens_hsa043700.66837767
113Fatty acid biosynthesis_Homo sapiens_hsa000610.66467285
114Endometrial cancer_Homo sapiens_hsa052130.64018042
115Malaria_Homo sapiens_hsa051440.63964422
116Endocytosis_Homo sapiens_hsa041440.63238450
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61943635
118Non-small cell lung cancer_Homo sapiens_hsa052230.61032235
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60942273
120Lysine degradation_Homo sapiens_hsa003100.60202612
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59995266
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59330931
123mRNA surveillance pathway_Homo sapiens_hsa030150.57118320
124Dilated cardiomyopathy_Homo sapiens_hsa054140.56956164
125Renal cell carcinoma_Homo sapiens_hsa052110.56425383
126Lysosome_Homo sapiens_hsa041420.56119908
127Ras signaling pathway_Homo sapiens_hsa040140.56084928
128Insulin signaling pathway_Homo sapiens_hsa049100.55759864
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55715580
130Vibrio cholerae infection_Homo sapiens_hsa051100.53940336
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.53892699
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53296662
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52836114
134Herpes simplex infection_Homo sapiens_hsa051680.52784899
135Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52389642
136Tight junction_Homo sapiens_hsa045300.52013681
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51998071
138Rap1 signaling pathway_Homo sapiens_hsa040150.51818488
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51040072
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50849234
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48068617
142Pathways in cancer_Homo sapiens_hsa052000.47292707
143HTLV-I infection_Homo sapiens_hsa051660.45529618
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.44952613
145Circadian rhythm_Homo sapiens_hsa047100.42355388
146Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42355304
147Ovarian steroidogenesis_Homo sapiens_hsa049130.40401095
148Chemokine signaling pathway_Homo sapiens_hsa040620.38444124
149AMPK signaling pathway_Homo sapiens_hsa041520.38056939
150Central carbon metabolism in cancer_Homo sapiens_hsa052300.37092252
151Vitamin B6 metabolism_Homo sapiens_hsa007500.36734454
152Prolactin signaling pathway_Homo sapiens_hsa049170.36732384
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.36243474
154Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35056830
155Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34822404
156Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34285204
157Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34105086
158Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33898230
159Wnt signaling pathway_Homo sapiens_hsa043100.33795566
160Cardiac muscle contraction_Homo sapiens_hsa042600.33417744

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