ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gamma-aminobutyric acid transport (GO:0015812)	4.01520796
2	neuronal action potential propagation (GO:0019227)	3.97155285
3	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.75987362
4	detection of light stimulus involved in sensory perception (GO:0050962)	3.64918721
5	detection of light stimulus involved in visual perception (GO:0050908)	3.64918721
6	behavioral response to nicotine (GO:0035095)	3.43687240
7	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.34010152
8	indolalkylamine metabolic process (GO:0006586)	3.27265672
9	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.25448001
10	establishment of protein localization to Golgi (GO:0072600)	3.22694041
11	piRNA metabolic process (GO:0034587)	3.18981937
12	regulation of establishment of cell polarity (GO:2000114)	3.18841782
13	membrane depolarization during action potential (GO:0086010)	3.15102528
14	glutamate receptor signaling pathway (GO:0007215)	3.12428652
15	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.09224907
16	serotonin metabolic process (GO:0042428)	3.08626305
17	neuronal action potential (GO:0019228)	3.06485314
18	axon ensheathment in central nervous system (GO:0032291)	3.04075810
19	central nervous system myelination (GO:0022010)	3.04075810
20	regulation of memory T cell differentiation (GO:0043380)	3.03982783
21	cerebellar Purkinje cell differentiation (GO:0021702)	3.02105200
22	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.01412252
23	synaptic transmission, glutamatergic (GO:0035249)	2.99863639
24	cilium or flagellum-dependent cell motility (GO:0001539)	2.99808306
25	negative regulation of Rho protein signal transduction (GO:0035024)	2.99056963
26	negative regulation of mast cell activation (GO:0033004)	2.97897704
27	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.97606142
28	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.95905869
29	proline transport (GO:0015824)	2.93015634
30	synaptic vesicle maturation (GO:0016188)	2.92935384
31	indole-containing compound catabolic process (GO:0042436)	2.91738446
32	indolalkylamine catabolic process (GO:0046218)	2.91738446
33	tryptophan catabolic process (GO:0006569)	2.91738446
34	cellular response to ATP (GO:0071318)	2.91145951
35	primary amino compound metabolic process (GO:1901160)	2.89122078
36	regulation of action potential (GO:0098900)	2.89025082
37	indole-containing compound metabolic process (GO:0042430)	2.87005847
38	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.86961197
39	adaptation of signaling pathway (GO:0023058)	2.85501453
40	behavioral response to ethanol (GO:0048149)	2.81769738
41	negative regulation of response to food (GO:0032096)	2.80826321
42	negative regulation of appetite (GO:0032099)	2.80826321
43	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.78915209
44	fucose catabolic process (GO:0019317)	2.78134104
45	L-fucose metabolic process (GO:0042354)	2.78134104
46	L-fucose catabolic process (GO:0042355)	2.78134104
47	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.77391435
48	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.76498488
49	DNA methylation involved in gamete generation (GO:0043046)	2.74756884
50	protein targeting to Golgi (GO:0000042)	2.72442095
51	regulation of sarcomere organization (GO:0060297)	2.72146106
52	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.71030536
53	cAMP catabolic process (GO:0006198)	2.69457592
54	adult walking behavior (GO:0007628)	2.68563631
55	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.68494831
56	positive regulation of vascular permeability (GO:0043117)	2.68154124
57	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.66549630
58	neuron-neuron synaptic transmission (GO:0007270)	2.65138078
59	regulation of inositol phosphate biosynthetic process (GO:0010919)	2.63202195
60	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.63072827
61	cyclic nucleotide catabolic process (GO:0009214)	2.62705633
62	neural tube formation (GO:0001841)	2.59742019
63	potassium ion transmembrane transport (GO:0071805)	2.58300902
64	cellular potassium ion transport (GO:0071804)	2.58300902
65	kynurenine metabolic process (GO:0070189)	2.56975867
66	photoreceptor cell maintenance (GO:0045494)	2.55982738
67	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.55789276
68	regulation of MHC class I biosynthetic process (GO:0045343)	2.54552793
69	snRNA transcription (GO:0009301)	2.54508480
70	nerve growth factor signaling pathway (GO:0038180)	2.54079755
71	transmission of nerve impulse (GO:0019226)	2.51910132
72	sulfation (GO:0051923)	2.51578105
73	tryptophan metabolic process (GO:0006568)	2.50174563
74	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.50111706
75	reflex (GO:0060004)	2.47784336
76	lipid translocation (GO:0034204)	2.46322443
77	phospholipid translocation (GO:0045332)	2.46322443
78	potassium ion transport (GO:0006813)	2.41794526
79	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.41187888
80	auditory behavior (GO:0031223)	2.40678133
81	membrane depolarization (GO:0051899)	2.40505653
82	neuromuscular process controlling posture (GO:0050884)	2.39824870
83	one-carbon compound transport (GO:0019755)	2.38164653
84	protein K11-linked deubiquitination (GO:0035871)	2.38067572
85	regulation of appetite (GO:0032098)	2.37781832
86	positive regulation of meiosis (GO:0045836)	2.37708231
87	synaptic transmission, cholinergic (GO:0007271)	2.37663952
88	negative regulation of neurotransmitter transport (GO:0051589)	2.36898712
89	response to pheromone (GO:0019236)	2.35782545
90	cellular ketone body metabolic process (GO:0046950)	2.35554412
91	positive regulation of vasculogenesis (GO:2001214)	2.34450542
92	phosphatidylethanolamine metabolic process (GO:0046337)	2.34255705
93	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.33693330
94	action potential (GO:0001508)	2.32765608
95	cell wall macromolecule catabolic process (GO:0016998)	2.32675449
96	negative regulation of type 2 immune response (GO:0002829)	2.32628369
97	cell wall macromolecule metabolic process (GO:0044036)	2.30465304
98	activated T cell proliferation (GO:0050798)	2.30132610
99	protein localization to Golgi apparatus (GO:0034067)	2.29564009
100	regulation of pigment cell differentiation (GO:0050932)	2.29271738

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.71878502
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.18060660
3	VDR_22108803_ChIP-Seq_LS180_Human	2.89937882
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.42324949
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.17486767
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.16830336
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.16297885
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.15932896
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.15840692
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.15198461
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.09817140
12	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.95132811
13	ER_23166858_ChIP-Seq_MCF-7_Human	1.92417652
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.90349037
15	FUS_26573619_Chip-Seq_HEK293_Human	1.90054235
16	REST_21632747_ChIP-Seq_MESCs_Mouse	1.83814695
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81498527
18	DROSHA_22980978_ChIP-Seq_HELA_Human	1.80513506
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.76128546
20	P300_19829295_ChIP-Seq_ESCs_Human	1.74796064
21	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72831851
22	AR_21572438_ChIP-Seq_LNCaP_Human	1.67661540
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.66672139
24	STAT3_23295773_ChIP-Seq_U87_Human	1.65569617
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.65199054
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63107332
27	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.58840906
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.58501973
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.58257198
30	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.54680138
31	TCF4_23295773_ChIP-Seq_U87_Human	1.54237987
32	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.46431159
33	AR_25329375_ChIP-Seq_VCAP_Human	1.45897849
34	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.42384781
35	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.42288905
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42260054
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.42260054
38	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.40847951
39	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.40607300
40	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.37123924
41	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36946442
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36234571
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34644797
44	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.33564832
45	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.30662368
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.30609924
47	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.30495453
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30317363
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.30317363
50	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.28483076
51	EWS_26573619_Chip-Seq_HEK293_Human	1.28425538
52	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28324675
53	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.25903447
54	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24918685
55	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24838899
56	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24704384
57	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.24053584
58	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.23984067
59	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23281139
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22798846
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.19984501
62	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.16524681
63	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.15969868
64	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.15893053
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15405001
66	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.14615733
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14605676
68	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14343268
69	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13911655
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.12617868
71	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.12514312
72	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11787322
73	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.11527756
74	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.11294301
75	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.10327137
76	AHR_22903824_ChIP-Seq_MCF-7_Human	1.10001145
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09719608
78	KDM2B_26808549_Chip-Seq_REH_Human	1.08768623
79	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08127867
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07407721
81	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.07148879
82	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.07109346
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.06551531
84	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05834167
85	TP53_16413492_ChIP-PET_HCT116_Human	1.05728483
86	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.05582378
87	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05145581
88	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04768709
89	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.04498332
90	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.04225706
91	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.04196124
92	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.04132613
93	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.03393729
94	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03334814
95	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.02142867
96	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99749772
97	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.99432065
98	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.99037086
99	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.98801069
100	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.96463760

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.52919996
2	MP0003880_abnormal_central_pattern	3.05751064
3	MP0001968_abnormal_touch/_nociception	3.02098897
4	MP0009745_abnormal_behavioral_response	3.01188387
5	MP0001486_abnormal_startle_reflex	2.67918111
6	MP0002064_seizures	2.65457629
7	MP0004859_abnormal_synaptic_plasticity	2.62840762
8	MP0003635_abnormal_synaptic_transmissio	2.61033070
9	MP0001501_abnormal_sleep_pattern	2.56671261
10	MP0009046_muscle_twitch	2.46384262
11	MP0002272_abnormal_nervous_system	2.45110471
12	MP0002102_abnormal_ear_morphology	2.38634023
13	MP0005551_abnormal_eye_electrophysiolog	2.29857234
14	MP0002572_abnormal_emotion/affect_behav	2.19368456
15	MP0008877_abnormal_DNA_methylation	2.14194055
16	MP0002735_abnormal_chemical_nociception	2.02656687
17	MP0002063_abnormal_learning/memory/cond	1.98466706
18	MP0001485_abnormal_pinna_reflex	1.98112008
19	MP0005423_abnormal_somatic_nervous	1.95606703
20	MP0002736_abnormal_nociception_after	1.91933860
21	MP0001986_abnormal_taste_sensitivity	1.91880670
22	MP0004885_abnormal_endolymph	1.90281576
23	MP0005174_abnormal_tail_pigmentation	1.81709595
24	MP0003878_abnormal_ear_physiology	1.80558815
25	MP0005377_hearing/vestibular/ear_phenot	1.80558815
26	MP0005646_abnormal_pituitary_gland	1.79000618
27	MP0004270_analgesia	1.64857150
28	MP0003787_abnormal_imprinting	1.51396106
29	MP0001970_abnormal_pain_threshold	1.51304910
30	MP0002067_abnormal_sensory_capabilities	1.51084897
31	MP0008872_abnormal_physiological_respon	1.50616675
32	MP0005253_abnormal_eye_physiology	1.49904935
33	MP0004742_abnormal_vestibular_system	1.48440798
34	MP0002653_abnormal_ependyma_morphology	1.47444246
35	MP0002734_abnormal_mechanical_nocicepti	1.46312213
36	MP0002638_abnormal_pupillary_reflex	1.45366250
37	MP0005386_behavior/neurological_phenoty	1.42681057
38	MP0004924_abnormal_behavior	1.42681057
39	MP0008569_lethality_at_weaning	1.38026865
40	MP0000427_abnormal_hair_cycle	1.35048620
41	MP0002733_abnormal_thermal_nociception	1.32545312
42	MP0004130_abnormal_muscle_cell	1.27308953
43	MP0003252_abnormal_bile_duct	1.26731715
44	MP0000383_abnormal_hair_follicle	1.24276519
45	MP0006276_abnormal_autonomic_nervous	1.21994989
46	MP0003633_abnormal_nervous_system	1.21193812
47	MP0005410_abnormal_fertilization	1.20946297
48	MP0003136_yellow_coat_color	1.20085796
49	MP0001963_abnormal_hearing_physiology	1.19625928
50	MP0005670_abnormal_white_adipose	1.18987824
51	MP0000015_abnormal_ear_pigmentation	1.15753036
52	MP0001440_abnormal_grooming_behavior	1.15553420
53	MP0002557_abnormal_social/conspecific_i	1.14808383
54	MP0004381_abnormal_hair_follicle	1.14570601
55	MP0002396_abnormal_hematopoietic_system	1.12746031
56	MP0003195_calcinosis	1.09908233
57	MP0002837_dystrophic_cardiac_calcinosis	1.09504265
58	MP0010386_abnormal_urinary_bladder	1.09311887
59	MP0002928_abnormal_bile_duct	1.09171403
60	MP0006072_abnormal_retinal_apoptosis	1.08440608
61	MP0002229_neurodegeneration	1.07849826
62	MP0003646_muscle_fatigue	1.07383711
63	MP0000230_abnormal_systemic_arterial	1.06017226
64	MP0002160_abnormal_reproductive_system	1.05552715
65	MP0003631_nervous_system_phenotype	1.04754236
66	MP0005075_abnormal_melanosome_morpholog	1.03212274
67	MP0001905_abnormal_dopamine_level	1.02389580
68	MP0004147_increased_porphyrin_level	1.02164718
69	MP0002095_abnormal_skin_pigmentation	0.98853450
70	MP0004142_abnormal_muscle_tone	0.98710257
71	MP0004043_abnormal_pH_regulation	0.96691751
72	MP0002882_abnormal_neuron_morphology	0.94167773
73	MP0003724_increased_susceptibility_to	0.93222293
74	MP0000372_irregular_coat_pigmentation	0.93008878
75	MP0005171_absent_coat_pigmentation	0.91627271
76	MP0000631_abnormal_neuroendocrine_gland	0.86699967
77	MP0002066_abnormal_motor_capabilities/c	0.85380920
78	MP0002138_abnormal_hepatobiliary_system	0.84747183
79	MP0003698_abnormal_male_reproductive	0.84515010
80	MP0004215_abnormal_myocardial_fiber	0.82685760
81	MP0005167_abnormal_blood-brain_barrier	0.81246808
82	MP0001502_abnormal_circadian_rhythm	0.81081217
83	MP0005645_abnormal_hypothalamus_physiol	0.79836682
84	MP0001984_abnormal_olfaction	0.79126760
85	MP0003632_abnormal_nervous_system	0.79095827
86	MP0004145_abnormal_muscle_electrophysio	0.78155531
87	MP0002876_abnormal_thyroid_physiology	0.77462336
88	MP0000026_abnormal_inner_ear	0.77380028
89	MP0005310_abnormal_salivary_gland	0.77189468
90	MP0003011_delayed_dark_adaptation	0.77167080
91	MP0001664_abnormal_digestion	0.75046242
92	MP0002277_abnormal_respiratory_mucosa	0.74459422
93	MP0002009_preneoplasia	0.74441905
94	MP0005389_reproductive_system_phenotype	0.74320474
95	MP0003045_fibrosis	0.73995535
96	MP0000371_diluted_coat_color	0.73850809
97	MP0001835_abnormal_antigen_presentation	0.73558157
98	MP0003690_abnormal_glial_cell	0.73360442
99	MP0002184_abnormal_innervation	0.72496019
100	MP0000778_abnormal_nervous_system	0.71480319

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	4.80581448
2	Progressive cerebellar ataxia (HP:0002073)	4.77290147
3	Febrile seizures (HP:0002373)	4.75854130
4	Focal seizures (HP:0007359)	4.20769180
5	Genetic anticipation (HP:0003743)	4.19002863
6	Hyperventilation (HP:0002883)	4.14396885
7	Gaze-evoked nystagmus (HP:0000640)	3.86644522
8	Atonic seizures (HP:0010819)	3.73645879
9	Absence seizures (HP:0002121)	3.40554336
10	Dialeptic seizures (HP:0011146)	3.39656819
11	Congenital stationary night blindness (HP:0007642)	3.39122074
12	Action tremor (HP:0002345)	3.21914376
13	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.13713010
14	Absent/shortened dynein arms (HP:0200106)	3.13713010
15	Abnormal drinking behavior (HP:0030082)	3.11265539
16	Polydipsia (HP:0001959)	3.11265539
17	Pancreatic cysts (HP:0001737)	3.09631916
18	Abolished electroretinogram (ERG) (HP:0000550)	2.97314256
19	Attenuation of retinal blood vessels (HP:0007843)	2.77703132
20	Inability to walk (HP:0002540)	2.76722332
21	Absent speech (HP:0001344)	2.75526386
22	Abnormality of binocular vision (HP:0011514)	2.72673360
23	Diplopia (HP:0000651)	2.72673360
24	Pancreatic fibrosis (HP:0100732)	2.66358493
25	Nephronophthisis (HP:0000090)	2.63064214
26	Hemiplegia (HP:0002301)	2.62921343
27	Protruding tongue (HP:0010808)	2.61559322
28	Hemiparesis (HP:0001269)	2.58586409
29	Abnormality of the renal cortex (HP:0011035)	2.55442970
30	Abnormality of midbrain morphology (HP:0002418)	2.52476362
31	Molar tooth sign on MRI (HP:0002419)	2.52476362
32	Epileptic encephalopathy (HP:0200134)	2.49872516
33	Postural instability (HP:0002172)	2.48189938
34	Panhypogammaglobulinemia (HP:0003139)	2.43332686
35	Stomach cancer (HP:0012126)	2.42818593
36	Clumsiness (HP:0002312)	2.42499679
37	Abnormality of the renal medulla (HP:0100957)	2.41150688
38	True hermaphroditism (HP:0010459)	2.40234662
39	Type II lissencephaly (HP:0007260)	2.36942103
40	Progressive inability to walk (HP:0002505)	2.36847624
41	Decreased central vision (HP:0007663)	2.32047950
42	Broad-based gait (HP:0002136)	2.31954651
43	Chronic hepatic failure (HP:0100626)	2.30206108
44	Bony spicule pigmentary retinopathy (HP:0007737)	2.29723569
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.26808134
46	Medial flaring of the eyebrow (HP:0010747)	2.26521883
47	Widely spaced teeth (HP:0000687)	2.25020175
48	Pendular nystagmus (HP:0012043)	2.22717697
49	Polyuria (HP:0000103)	2.22440712
50	Keratoconus (HP:0000563)	2.21558006
51	Increased corneal curvature (HP:0100692)	2.21558006
52	Abnormality of macular pigmentation (HP:0008002)	2.20612687
53	Myokymia (HP:0002411)	2.20535924
54	Status epilepticus (HP:0002133)	2.15512919
55	Impaired smooth pursuit (HP:0007772)	2.09821831
56	Abnormal respiratory epithelium morphology (HP:0012253)	2.07787223
57	Abnormal respiratory motile cilium morphology (HP:0005938)	2.07787223
58	Thyroiditis (HP:0100646)	2.05741716
59	Abnormal ciliary motility (HP:0012262)	2.04460458
60	Generalized tonic-clonic seizures (HP:0002069)	2.03546304
61	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.02931715
62	Congenital sensorineural hearing impairment (HP:0008527)	2.02420521
63	Papilledema (HP:0001085)	1.98676534
64	Gait imbalance (HP:0002141)	1.98540447
65	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.97530384
66	Fair hair (HP:0002286)	1.96939765
67	Chorioretinal atrophy (HP:0000533)	1.95768517
68	Urinary bladder sphincter dysfunction (HP:0002839)	1.95062178
69	Dysmetric saccades (HP:0000641)	1.94471763
70	Dysdiadochokinesis (HP:0002075)	1.94308614
71	Stenosis of the external auditory canal (HP:0000402)	1.93827373
72	Failure to thrive in infancy (HP:0001531)	1.93659020
73	Cystic liver disease (HP:0006706)	1.92993716
74	Abnormality of the hepatic vasculature (HP:0006707)	1.91825241
75	Recurrent corneal erosions (HP:0000495)	1.91100118
76	Generalized hypopigmentation of hair (HP:0011358)	1.90653413
77	Drooling (HP:0002307)	1.89761118
78	Macroglossia (HP:0000158)	1.85583491
79	Decreased circulating renin level (HP:0003351)	1.83320792
80	Tubular atrophy (HP:0000092)	1.82625401
81	Excessive salivation (HP:0003781)	1.79853263
82	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.77367607
83	Abnormality of ocular smooth pursuit (HP:0000617)	1.75506192
84	Abnormal urine output (HP:0012590)	1.72318143
85	Congenital hepatic fibrosis (HP:0002612)	1.71785188
86	Hypoplastic iliac wings (HP:0002866)	1.71547619
87	Congenital primary aphakia (HP:0007707)	1.70094350
88	Renal cortical cysts (HP:0000803)	1.69564792
89	Cerebellar dysplasia (HP:0007033)	1.69362504
90	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.67078441
91	Retinitis pigmentosa (HP:0000510)	1.66646950
92	Tetany (HP:0001281)	1.66338218
93	Abnormality of B cell number (HP:0010975)	1.65175255
94	Stereotypic behavior (HP:0000733)	1.64775800
95	Abnormal EKG (HP:0003115)	1.63725759
96	Acute lymphatic leukemia (HP:0006721)	1.63223036
97	Hyperkalemia (HP:0002153)	1.61757957
98	Genital tract atresia (HP:0001827)	1.61357217
99	Portal hypertension (HP:0001409)	1.60776328
100	Hypochromic microcytic anemia (HP:0004840)	1.60435554

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.72133189
2	ACVR1B	2.71750356
3	BMPR1B	2.67445613
4	DAPK2	2.53372684
5	TAOK3	2.46763037
6	CDK19	2.25100237
7	OXSR1	1.99641737
8	ADRBK2	1.99533839
9	NTRK3	1.92004150
10	MAPK13	1.90874094
11	KIT	1.87394333
12	GRK1	1.78067847
13	PINK1	1.67736645
14	EPHA4	1.58032464
15	MARK1	1.49333694
16	FLT3	1.47571030
17	MAP3K4	1.47055646
18	MAP3K7	1.42075767
19	TNK2	1.39459594
20	TXK	1.34049388
21	PAK6	1.32258969
22	RIPK4	1.21104446
23	NTRK2	1.20340326
24	INSRR	1.17034551
25	MKNK2	1.14161242
26	CASK	1.12894019
27	SGK2	1.08437843
28	BLK	1.06215600
29	PIK3CG	1.04192571
30	STK11	1.01770762
31	PAK3	1.01767726
32	FGFR2	0.99470691
33	TEC	0.98825324
34	MAPK7	0.97694876
35	WNK3	0.96839550
36	SYK	0.96278139
37	PRKCH	0.94258586
38	PRKCG	0.93287398
39	FES	0.93091226
40	PNCK	0.92514956
41	STK39	0.92438375
42	CAMK1	0.92330680
43	STK38	0.90183835
44	MUSK	0.89483122
45	IKBKE	0.88381782
46	PTK2B	0.86721205
47	TGFBR1	0.86718507
48	ADRBK1	0.85718672
49	PLK2	0.84558597
50	DYRK1A	0.84402720
51	SIK2	0.84159945
52	CSF1R	0.83764958
53	MAP2K6	0.81925240
54	STK38L	0.80454241
55	NUAK1	0.80206411
56	PKN1	0.79711098
57	GRK5	0.79185156
58	MAPK12	0.77294177
59	SGK494	0.76766405
60	SGK223	0.76766405
61	PIK3CA	0.75455379
62	UHMK1	0.75196048
63	CAMK2A	0.73555781
64	PRKCE	0.72108980
65	CAMKK2	0.70305522
66	PRKCQ	0.70083483
67	WNK4	0.66310024
68	CDK3	0.66190652
69	SGK1	0.64800669
70	ITK	0.63172036
71	PRKG2	0.63052803
72	PDK1	0.62390367
73	NLK	0.62353027
74	MAP4K2	0.60495098
75	CAMKK1	0.59231589
76	MAPKAPK5	0.59004185
77	CAMK4	0.58321038
78	MAP2K4	0.56207650
79	WNK1	0.55770425
80	CDK5	0.55759936
81	MAP2K1	0.54725742
82	IRAK1	0.53174307
83	MAPK15	0.52814635
84	MAP2K7	0.52758788
85	SGK3	0.51773443
86	AKT3	0.50974652
87	EIF2AK3	0.50537950
88	MAP3K13	0.50366873
89	PRKCZ	0.49964795
90	CSNK1D	0.48314372
91	IKBKB	0.47466248
92	PRKG1	0.47004750
93	PHKG1	0.44551557
94	PHKG2	0.44551557
95	PRKAA2	0.43476067
96	TYRO3	0.43327765
97	ZAK	0.42718904
98	PRKACA	0.40716268
99	LYN	0.39744539
100	BMPR2	0.39163005

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.19228918
2	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.24034395
3	Morphine addiction_Homo sapiens_hsa05032	2.17579657
4	Phototransduction_Homo sapiens_hsa04744	2.16525738
5	Circadian entrainment_Homo sapiens_hsa04713	2.11517467
6	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.09991454
7	Glutamatergic synapse_Homo sapiens_hsa04724	2.00665051
8	Taste transduction_Homo sapiens_hsa04742	1.97076942
9	Olfactory transduction_Homo sapiens_hsa04740	1.92784956
10	Salivary secretion_Homo sapiens_hsa04970	1.88082963
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.86734209
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.86573488
13	GABAergic synapse_Homo sapiens_hsa04727	1.78980576
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.78360107
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.76137489
16	Insulin secretion_Homo sapiens_hsa04911	1.65096967
17	Renin secretion_Homo sapiens_hsa04924	1.61020133
18	Calcium signaling pathway_Homo sapiens_hsa04020	1.55985039
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.54642241
20	Long-term depression_Homo sapiens_hsa04730	1.50051089
21	ABC transporters_Homo sapiens_hsa02010	1.44821183
22	Serotonergic synapse_Homo sapiens_hsa04726	1.43140043
23	Butanoate metabolism_Homo sapiens_hsa00650	1.40040246
24	Amphetamine addiction_Homo sapiens_hsa05031	1.38856542
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.38321967
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.38124672
27	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.34265806
28	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.33365488
29	Gastric acid secretion_Homo sapiens_hsa04971	1.32164690
30	Cocaine addiction_Homo sapiens_hsa05030	1.24449078
31	Dopaminergic synapse_Homo sapiens_hsa04728	1.23899865
32	Cholinergic synapse_Homo sapiens_hsa04725	1.23590775
33	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.22963559
34	cAMP signaling pathway_Homo sapiens_hsa04024	1.22694272
35	Long-term potentiation_Homo sapiens_hsa04720	1.17526542
36	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.14452470
37	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.13405626
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.11009949
39	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.10438998
40	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.10300448
41	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.00291248
42	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.00151821
43	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.99552040
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.99208220
45	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.97359987
46	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.94487505
47	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.94325495
48	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.90619941
49	Histidine metabolism_Homo sapiens_hsa00340	0.89538052
50	Primary immunodeficiency_Homo sapiens_hsa05340	0.88908820
51	Pancreatic secretion_Homo sapiens_hsa04972	0.88764927
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.88623017
53	Regulation of autophagy_Homo sapiens_hsa04140	0.87856595
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.86431550
55	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.85206251
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.82940830
57	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.80834696
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.80817277
59	MAPK signaling pathway_Homo sapiens_hsa04010	0.79760972
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.78165264
61	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.78083742
62	Type II diabetes mellitus_Homo sapiens_hsa04930	0.75037555
63	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.74444205
64	Platelet activation_Homo sapiens_hsa04611	0.73759937
65	Circadian rhythm_Homo sapiens_hsa04710	0.72033548
66	Asthma_Homo sapiens_hsa05310	0.68995720
67	Ras signaling pathway_Homo sapiens_hsa04014	0.68501488
68	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.67405672
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.66197927
70	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66184912
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.65688946
72	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.62498705
73	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.60484467
74	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.58411661
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55535770
76	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.54595757
77	Graft-versus-host disease_Homo sapiens_hsa05332	0.54003147
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.53686248
79	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.52270647
80	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.51067553
81	African trypanosomiasis_Homo sapiens_hsa05143	0.50616031
82	Choline metabolism in cancer_Homo sapiens_hsa05231	0.50485440
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49725178
84	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.49145956
85	GnRH signaling pathway_Homo sapiens_hsa04912	0.48652816
86	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.48085642
87	Melanoma_Homo sapiens_hsa05218	0.46811198
88	Estrogen signaling pathway_Homo sapiens_hsa04915	0.45272108
89	Gap junction_Homo sapiens_hsa04540	0.44471651
90	Type I diabetes mellitus_Homo sapiens_hsa04940	0.43948200
91	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.42047999
92	Allograft rejection_Homo sapiens_hsa05330	0.41305222
93	Chemical carcinogenesis_Homo sapiens_hsa05204	0.39930431
94	Cardiac muscle contraction_Homo sapiens_hsa04260	0.37866286
95	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.37571387
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36561807
97	FoxO signaling pathway_Homo sapiens_hsa04068	0.36249058
98	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.36107043
99	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.32746473
100	Rap1 signaling pathway_Homo sapiens_hsa04015	0.32241809

USP32P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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