ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	5.75312625
2	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.76633834
3	synapsis (GO:0007129)	4.57448978
4	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.54686408
5	neuronal action potential propagation (GO:0019227)	4.30181600
6	synaptic vesicle maturation (GO:0016188)	4.24119282
7	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.95757736
8	male meiosis (GO:0007140)	3.93266843
9	DNA methylation involved in gamete generation (GO:0043046)	3.92697494
10	male meiosis I (GO:0007141)	3.90624302
11	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.79183670
12	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.70677272
13	postsynaptic membrane organization (GO:0001941)	3.68404376
14	gamma-aminobutyric acid transport (GO:0015812)	3.68200305
15	membrane depolarization during action potential (GO:0086010)	3.55664956
16	glycosphingolipid biosynthetic process (GO:0006688)	3.52502470
17	response to pheromone (GO:0019236)	3.52248316
18	chromosome organization involved in meiosis (GO:0070192)	3.50534771
19	glutamate secretion (GO:0014047)	3.50242817
20	regulation of synaptic vesicle exocytosis (GO:2000300)	3.49381131
21	transmission of nerve impulse (GO:0019226)	3.47129651
22	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.45247841
23	synaptic vesicle exocytosis (GO:0016079)	3.43583318
24	presynaptic membrane assembly (GO:0097105)	3.41491857
25	presynaptic membrane organization (GO:0097090)	3.40699961
26	detection of light stimulus involved in sensory perception (GO:0050962)	3.38599451
27	detection of light stimulus involved in visual perception (GO:0050908)	3.38599451
28	synaptic transmission, glutamatergic (GO:0035249)	3.34760417
29	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.30179324
30	neuron-neuron synaptic transmission (GO:0007270)	3.25936279
31	neuron cell-cell adhesion (GO:0007158)	3.25139984
32	mechanosensory behavior (GO:0007638)	3.22194391
33	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.18966588
34	potassium ion import (GO:0010107)	3.18879749
35	neurotransmitter-gated ion channel clustering (GO:0072578)	3.18339029
36	locomotory exploration behavior (GO:0035641)	3.17112903
37	proline transport (GO:0015824)	3.16869554
38	glutamate receptor signaling pathway (GO:0007215)	3.16193093
39	behavioral response to ethanol (GO:0048149)	3.15777286
40	regulation of synaptic vesicle transport (GO:1902803)	3.15236283
41	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.11463353
42	establishment of protein localization to Golgi (GO:0072600)	3.03121328
43	neurotransmitter secretion (GO:0007269)	3.00963956
44	negative regulation of neurotransmitter transport (GO:0051589)	3.00154314
45	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.99868072
46	C4-dicarboxylate transport (GO:0015740)	2.96641108
47	auditory behavior (GO:0031223)	2.96453512
48	synaptonemal complex organization (GO:0070193)	2.96045143
49	retinal cone cell development (GO:0046549)	2.95053818
50	L-amino acid import (GO:0043092)	2.93797960
51	synaptonemal complex assembly (GO:0007130)	2.92978252
52	meiosis I (GO:0007127)	2.90205479
53	neurotransmitter uptake (GO:0001504)	2.89964514
54	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.88540761
55	sodium ion export (GO:0071436)	2.87276080
56	protein localization to synapse (GO:0035418)	2.87003326
57	regulation of female receptivity (GO:0045924)	2.86985197
58	regulation of glutamate receptor signaling pathway (GO:1900449)	2.84322337
59	vocalization behavior (GO:0071625)	2.83907478
60	neuronal action potential (GO:0019228)	2.82319104
61	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.81857428
62	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.79620109
63	regulation of excitatory postsynaptic membrane potential (GO:0060079)	2.78675925
64	positive regulation of meiosis (GO:0045836)	2.78616127
65	regulation of meiosis I (GO:0060631)	2.78506136
66	fucose catabolic process (GO:0019317)	2.77568907
67	L-fucose metabolic process (GO:0042354)	2.77568907
68	L-fucose catabolic process (GO:0042355)	2.77568907
69	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.76417928
70	meiotic nuclear division (GO:0007126)	2.76329054
71	cAMP catabolic process (GO:0006198)	2.76090067
72	cyclic nucleotide catabolic process (GO:0009214)	2.75551995
73	regulation of neurotransmitter secretion (GO:0046928)	2.75403673
74	DNA synthesis involved in DNA repair (GO:0000731)	2.74755891
75	membrane depolarization (GO:0051899)	2.72684620
76	negative regulation of cAMP-mediated signaling (GO:0043951)	2.72599275
77	regulation of neurotransmitter transport (GO:0051588)	2.71032471
78	cellular potassium ion homeostasis (GO:0030007)	2.69371583
79	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.68914073
80	neuronal ion channel clustering (GO:0045161)	2.68583142
81	protein targeting to Golgi (GO:0000042)	2.67959447
82	neurotransmitter transport (GO:0006836)	2.67053303
83	regulation of dendritic spine development (GO:0060998)	2.67033246
84	regulation of protein glycosylation (GO:0060049)	2.66964499
85	cellular potassium ion transport (GO:0071804)	2.63984239
86	potassium ion transmembrane transport (GO:0071805)	2.63984239
87	central nervous system myelination (GO:0022010)	2.63216912
88	axon ensheathment in central nervous system (GO:0032291)	2.63216912
89	regulation of postsynaptic membrane potential (GO:0060078)	2.59134987
90	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.58370370
91	adult walking behavior (GO:0007628)	2.55226653
92	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.54732954
93	inositol phosphate catabolic process (GO:0071545)	2.53406307
94	positive regulation of membrane potential (GO:0045838)	2.52586436
95	positive regulation of meiotic cell cycle (GO:0051446)	2.51898936
96	potassium ion transport (GO:0006813)	2.51225586
97	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.51189011
98	negative regulation of inclusion body assembly (GO:0090084)	2.51010930
99	calcium ion-dependent exocytosis (GO:0017156)	2.51010515
100	sister chromatid cohesion (GO:0007062)	2.50725619

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.44604847
2	EZH2_22144423_ChIP-Seq_EOC_Human	2.82044701
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.56070270
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.55955549
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.50353966
6	VDR_22108803_ChIP-Seq_LS180_Human	2.44100314
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35435288
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.25070770
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.22237475
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.15073109
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.15072175
12	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.11213558
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.09781449
14	FUS_26573619_Chip-Seq_HEK293_Human	2.04565533
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.98311098
16	REST_21632747_ChIP-Seq_MESCs_Mouse	1.97325594
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.90868656
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88096397
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.86733739
20	SMAD4_21799915_ChIP-Seq_A2780_Human	1.85932617
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.85674749
22	P300_19829295_ChIP-Seq_ESCs_Human	1.84930300
23	STAT3_23295773_ChIP-Seq_U87_Human	1.80741404
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.79951223
25	DROSHA_22980978_ChIP-Seq_HELA_Human	1.73460158
26	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.71062194
27	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.71062194
28	TCF4_23295773_ChIP-Seq_U87_Human	1.70767117
29	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.67064482
30	AR_21572438_ChIP-Seq_LNCaP_Human	1.66375671
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.62118188
32	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.55962861
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55372366
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55232407
35	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.54099490
36	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.53657394
37	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.53212702
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.48743983
39	AR_25329375_ChIP-Seq_VCAP_Human	1.48474038
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46994871
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.46994871
42	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.46644545
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.45525251
44	EWS_26573619_Chip-Seq_HEK293_Human	1.45496973
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.44516401
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.42893348
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41622953
48	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.40534743
49	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.40331072
50	RUNX2_22187159_ChIP-Seq_PCA_Human	1.40193823
51	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39937633
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38825585
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.38698907
54	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37706903
55	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.37344101
56	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.36454369
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36365127
58	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.34721159
59	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.32365625
60	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.31621434
61	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.28854535
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26158222
63	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.25462350
64	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.23549915
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22028846
66	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.21880561
67	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.21328360
68	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.21270267
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20432169
70	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.20032966
71	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.18907805
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18290707
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.17265496
74	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17137046
75	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16186430
76	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.15872703
77	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.13913324
78	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12371660
79	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.12150891
80	P53_22387025_ChIP-Seq_ESCs_Mouse	1.12149087
81	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12101926
82	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.11579128
83	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.10520347
84	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.10077893
85	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09333089
86	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09333089
87	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.08958769
88	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.07394866
89	TP53_16413492_ChIP-PET_HCT116_Human	1.07170231
90	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.05805117
91	KDM2B_26808549_Chip-Seq_REH_Human	1.05340563
92	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05337327
93	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.05220172
94	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.05052695
95	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04295636
96	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02108714
97	TP53_22573176_ChIP-Seq_HFKS_Human	1.01908367
98	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00662482
99	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.99753413
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99694901

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	4.66772064
2	MP0001968_abnormal_touch/_nociception	3.76171510
3	MP0004859_abnormal_synaptic_plasticity	3.52569599
4	MP0001501_abnormal_sleep_pattern	3.25335547
5	MP0008877_abnormal_DNA_methylation	3.18008860
6	MP0009745_abnormal_behavioral_response	3.02950441
7	MP0002064_seizures	2.93717929
8	MP0001486_abnormal_startle_reflex	2.91900194
9	MP0003635_abnormal_synaptic_transmissio	2.91180736
10	MP0000569_abnormal_digit_pigmentation	2.83015964
11	MP0009046_muscle_twitch	2.77152945
12	MP0002272_abnormal_nervous_system	2.67545204
13	MP0002736_abnormal_nociception_after	2.59665490
14	MP0005423_abnormal_somatic_nervous	2.56365531
15	MP0002063_abnormal_learning/memory/cond	2.42864354
16	MP0004270_analgesia	2.19855756
17	MP0002572_abnormal_emotion/affect_behav	2.19677253
18	MP0005551_abnormal_eye_electrophysiolog	2.07604172
19	MP0004885_abnormal_endolymph	2.03793521
20	MP0005646_abnormal_pituitary_gland	1.99277388
21	MP0002734_abnormal_mechanical_nocicepti	1.91711169
22	MP0001986_abnormal_taste_sensitivity	1.82620130
23	MP0003787_abnormal_imprinting	1.81677080
24	MP0002067_abnormal_sensory_capabilities	1.80779179
25	MP0002735_abnormal_chemical_nociception	1.79894426
26	MP0004742_abnormal_vestibular_system	1.79574683
27	MP0001970_abnormal_pain_threshold	1.74945736
28	MP0002102_abnormal_ear_morphology	1.70173666
29	MP0005386_behavior/neurological_phenoty	1.65282399
30	MP0004924_abnormal_behavior	1.65282399
31	MP0002733_abnormal_thermal_nociception	1.65050862
32	MP0004147_increased_porphyrin_level	1.64389888
33	MP0003633_abnormal_nervous_system	1.57752349
34	MP0005167_abnormal_blood-brain_barrier	1.52061534
35	MP0003878_abnormal_ear_physiology	1.47358137
36	MP0005377_hearing/vestibular/ear_phenot	1.47358137
37	MP0008569_lethality_at_weaning	1.46184475
38	MP0002557_abnormal_social/conspecific_i	1.42967844
39	MP0008872_abnormal_physiological_respon	1.36133927
40	MP0001502_abnormal_circadian_rhythm	1.34319980
41	MP0003698_abnormal_male_reproductive	1.33423134
42	MP0000427_abnormal_hair_cycle	1.31687323
43	MP0005253_abnormal_eye_physiology	1.30661119
44	MP0004043_abnormal_pH_regulation	1.28520761
45	MP0003646_muscle_fatigue	1.23185356
46	MP0003690_abnormal_glial_cell	1.20055189
47	MP0005174_abnormal_tail_pigmentation	1.19166153
48	MP0006276_abnormal_autonomic_nervous	1.18754451
49	MP0005645_abnormal_hypothalamus_physiol	1.17798275
50	MP0001963_abnormal_hearing_physiology	1.17021319
51	MP0001440_abnormal_grooming_behavior	1.16877438
52	MP0005410_abnormal_fertilization	1.16824156
53	MP0003631_nervous_system_phenotype	1.14425223
54	MP0002229_neurodegeneration	1.14043919
55	MP0000778_abnormal_nervous_system	1.13864373
56	MP0003172_abnormal_lysosome_physiology	1.13154533
57	MP0001984_abnormal_olfaction	1.11148556
58	MP0001929_abnormal_gametogenesis	1.10707082
59	MP0001177_atelectasis	1.09280254
60	MP0001485_abnormal_pinna_reflex	1.09223481
61	MP0000015_abnormal_ear_pigmentation	1.08454527
62	MP0002009_preneoplasia	1.06669992
63	MP0005075_abnormal_melanosome_morpholog	1.06045078
64	MP0002882_abnormal_neuron_morphology	1.05819347
65	MP0002066_abnormal_motor_capabilities/c	1.05152429
66	MP0000383_abnormal_hair_follicle	1.02147564
67	MP0002876_abnormal_thyroid_physiology	1.00704466
68	MP0004811_abnormal_neuron_physiology	0.99066402
69	MP0006072_abnormal_retinal_apoptosis	0.98907218
70	MP0000920_abnormal_myelination	0.95856846
71	MP0002095_abnormal_skin_pigmentation	0.95779077
72	MP0008057_abnormal_DNA_replication	0.94743732
73	MP0002210_abnormal_sex_determination	0.93418336
74	MP0004142_abnormal_muscle_tone	0.90079518
75	MP0005310_abnormal_salivary_gland	0.88602630
76	MP0000955_abnormal_spinal_cord	0.88397370
77	MP0004215_abnormal_myocardial_fiber	0.87089542
78	MP0002184_abnormal_innervation	0.84396788
79	MP0002638_abnormal_pupillary_reflex	0.83464097
80	MP0002160_abnormal_reproductive_system	0.82594144
81	MP0003879_abnormal_hair_cell	0.81377222
82	MP0000631_abnormal_neuroendocrine_gland	0.77382189
83	MP0008995_early_reproductive_senescence	0.76353120
84	MP0001145_abnormal_male_reproductive	0.75728374
85	MP0002928_abnormal_bile_duct	0.75640706
86	MP0000653_abnormal_sex_gland	0.72711792
87	MP0003045_fibrosis	0.70829867
88	MP0002752_abnormal_somatic_nervous	0.67891851
89	MP0009278_abnormal_bone_marrow	0.67258240
90	MP0005389_reproductive_system_phenotype	0.66433311
91	MP0001905_abnormal_dopamine_level	0.66226667
92	MP0002653_abnormal_ependyma_morphology	0.63924842
93	MP0002152_abnormal_brain_morphology	0.63676605
94	MP0009780_abnormal_chondrocyte_physiolo	0.63537591
95	MP0005535_abnormal_body_temperature	0.61831785
96	MP0004085_abnormal_heartbeat	0.60772781
97	MP0010678_abnormal_skin_adnexa	0.59954402
98	MP0000026_abnormal_inner_ear	0.59680533
99	MP0003632_abnormal_nervous_system	0.58326750
100	MP0000230_abnormal_systemic_arterial	0.58167186

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	5.48833304
2	Febrile seizures (HP:0002373)	5.05455223
3	Hyperventilation (HP:0002883)	4.71985959
4	Focal seizures (HP:0007359)	4.26531291
5	Volvulus (HP:0002580)	4.22318546
6	Atonic seizures (HP:0010819)	4.17406856
7	Gaze-evoked nystagmus (HP:0000640)	3.75973832
8	Progressive cerebellar ataxia (HP:0002073)	3.73613350
9	Epileptic encephalopathy (HP:0200134)	3.40286020
10	Absent speech (HP:0001344)	3.38486363
11	Dialeptic seizures (HP:0011146)	3.09566509
12	Abnormality of binocular vision (HP:0011514)	3.07968773
13	Diplopia (HP:0000651)	3.07968773
14	Hemiparesis (HP:0001269)	3.05136441
15	Action tremor (HP:0002345)	3.05101322
16	Broad-based gait (HP:0002136)	3.03505978
17	Protruding tongue (HP:0010808)	2.93731158
18	Genetic anticipation (HP:0003743)	2.83263841
19	Generalized tonic-clonic seizures (HP:0002069)	2.78953266
20	Hemiplegia (HP:0002301)	2.76124298
21	Myokymia (HP:0002411)	2.73147812
22	Attenuation of retinal blood vessels (HP:0007843)	2.68583730
23	Absence seizures (HP:0002121)	2.66083497
24	Amyotrophic lateral sclerosis (HP:0007354)	2.64222271
25	Type II lissencephaly (HP:0007260)	2.58208339
26	Congenital stationary night blindness (HP:0007642)	2.57556004
27	Dysdiadochokinesis (HP:0002075)	2.56945295
28	Pancreatic cysts (HP:0001737)	2.53475449
29	Widely spaced teeth (HP:0000687)	2.52454615
30	Abnormality of the renal cortex (HP:0011035)	2.48579077
31	Drooling (HP:0002307)	2.45952479
32	Postural instability (HP:0002172)	2.44035357
33	Spastic gait (HP:0002064)	2.41711315
34	Fair hair (HP:0002286)	2.38641992
35	Thyroid-stimulating hormone excess (HP:0002925)	2.37401257
36	Abnormal drinking behavior (HP:0030082)	2.37297494
37	Polydipsia (HP:0001959)	2.37297494
38	Abnormality of the renal medulla (HP:0100957)	2.35121888
39	Nephronophthisis (HP:0000090)	2.34130662
40	Progressive inability to walk (HP:0002505)	2.33365120
41	Molar tooth sign on MRI (HP:0002419)	2.33010067
42	Abnormality of midbrain morphology (HP:0002418)	2.33010067
43	Excessive salivation (HP:0003781)	2.32983701
44	Limb dystonia (HP:0002451)	2.32487826
45	Chronic hepatic failure (HP:0100626)	2.31142145
46	Keratoconus (HP:0000563)	2.29465029
47	Increased corneal curvature (HP:0100692)	2.29465029
48	Inability to walk (HP:0002540)	2.26008889
49	Generalized hypopigmentation of hair (HP:0011358)	2.23790809
50	Gait imbalance (HP:0002141)	2.19878507
51	Truncal ataxia (HP:0002078)	2.19320016
52	Clumsiness (HP:0002312)	2.18319512
53	Pancreatic fibrosis (HP:0100732)	2.18004410
54	Medial flaring of the eyebrow (HP:0010747)	2.17417947
55	Decreased central vision (HP:0007663)	2.16666208
56	Status epilepticus (HP:0002133)	2.16367613
57	Oligodactyly (hands) (HP:0001180)	2.14989592
58	Tubulointerstitial nephritis (HP:0001970)	2.13337737
59	Abolished electroretinogram (ERG) (HP:0000550)	2.11691253
60	Stomach cancer (HP:0012126)	2.08605768
61	Intention tremor (HP:0002080)	2.08595511
62	Urinary bladder sphincter dysfunction (HP:0002839)	2.07705278
63	Poor eye contact (HP:0000817)	2.06949705
64	Impaired vibration sensation in the lower limbs (HP:0002166)	2.04671434
65	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.04544650
66	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.04544650
67	Truncal obesity (HP:0001956)	2.04365116
68	Abnormality of the corticospinal tract (HP:0002492)	1.96925998
69	Cerebellar dysplasia (HP:0007033)	1.96009719
70	Abnormality of ocular smooth pursuit (HP:0000617)	1.95723481
71	Abnormal eating behavior (HP:0100738)	1.94637178
72	Congenital primary aphakia (HP:0007707)	1.94120521
73	Abnormality of the lower motor neuron (HP:0002366)	1.93774280
74	Horizontal nystagmus (HP:0000666)	1.90390906
75	Lower limb muscle weakness (HP:0007340)	1.89102051
76	Tented upper lip vermilion (HP:0010804)	1.88977976
77	Intestinal atresia (HP:0011100)	1.83711934
78	True hermaphroditism (HP:0010459)	1.83264478
79	Dyskinesia (HP:0100660)	1.83160765
80	Papilledema (HP:0001085)	1.82223835
81	Retinal dysplasia (HP:0007973)	1.81862922
82	Impaired smooth pursuit (HP:0007772)	1.81388714
83	Impaired vibratory sensation (HP:0002495)	1.78232750
84	Hyperkalemia (HP:0002153)	1.77386037
85	Dysmetria (HP:0001310)	1.76819253
86	Thickened helices (HP:0000391)	1.76246587
87	Prolonged QT interval (HP:0001657)	1.75918235
88	Hypokalemic alkalosis (HP:0001949)	1.74143981
89	Genital tract atresia (HP:0001827)	1.72986590
90	Progressive microcephaly (HP:0000253)	1.71961586
91	Nephrogenic diabetes insipidus (HP:0009806)	1.69604876
92	Spastic tetraparesis (HP:0001285)	1.68984409
93	Renal cortical cysts (HP:0000803)	1.68661564
94	Polyuria (HP:0000103)	1.67254581
95	Bony spicule pigmentary retinopathy (HP:0007737)	1.66087154
96	Supranuclear gaze palsy (HP:0000605)	1.65377080
97	Cystic liver disease (HP:0006706)	1.65046005
98	Ankle clonus (HP:0011448)	1.65033315
99	Long nose (HP:0003189)	1.65003458
100	Epileptiform EEG discharges (HP:0011182)	1.64250438

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.42521735
2	EPHA4	3.03576928
3	CASK	2.54047335
4	ADRBK2	2.51596778
5	NTRK3	2.40231056
6	PNCK	2.38655919
7	MARK1	2.32014279
8	DAPK2	2.25966864
9	MAPK13	2.15299564
10	TAOK3	1.90508896
11	NTRK2	1.85158180
12	TIE1	1.74849177
13	OXSR1	1.68741983
14	MAP3K13	1.65393859
15	PLK2	1.64015601
16	BMPR1B	1.63969069
17	CAMKK2	1.62487850
18	MAP3K4	1.61066452
19	ACVR1B	1.61047509
20	MAP4K2	1.49345196
21	GRK1	1.46610518
22	CDK19	1.43359782
23	PINK1	1.43290395
24	PAK6	1.37599009
25	WNK3	1.37097058
26	FGFR2	1.36026397
27	CAMKK1	1.34181847
28	TNK2	1.32164753
29	SGK2	1.27693486
30	FES	1.24492538
31	MKNK2	1.21337431
32	CAMK1	1.17066595
33	STK38	1.15306024
34	STK38L	1.13144162
35	INSRR	1.09581849
36	PRKD3	1.07960317
37	PAK3	1.07137384
38	PRKCG	1.07068157
39	RIPK4	1.05899304
40	UHMK1	1.05700215
41	PTK2B	1.03721044
42	DYRK1A	0.99730907
43	TEC	0.99410716
44	SGK223	0.99107415
45	SGK494	0.99107415
46	AKT3	0.98339547
47	STK39	0.93908275
48	STK11	0.91236242
49	CAMK1G	0.84933657
50	PKN1	0.83857897
51	PRKCE	0.82429366
52	TXK	0.82337414
53	SGK1	0.81982280
54	MAP2K6	0.81786235
55	GRK5	0.80993375
56	PRKCH	0.79458675
57	CAMK2A	0.79430856
58	CDK5	0.76502508
59	MINK1	0.76375271
60	WNK1	0.73280155
61	SIK2	0.71611387
62	PDK1	0.71239897
63	TYRO3	0.69809725
64	CDK3	0.67161487
65	MAPK7	0.66451984
66	KIT	0.66121268
67	PHKG2	0.66082090
68	PHKG1	0.66082090
69	ADRBK1	0.65817869
70	CAMK4	0.63300553
71	ITK	0.63103444
72	SGK3	0.61391015
73	NUAK1	0.61015028
74	SYK	0.59013278
75	BRD4	0.58919255
76	CAMK2B	0.57320156
77	PRKCZ	0.54464354
78	PRKCQ	0.53969709
79	EIF2AK3	0.53918866
80	IRAK1	0.53808843
81	NEK6	0.53775429
82	CSNK1G2	0.53646623
83	MAP2K4	0.49457301
84	FER	0.45161949
85	MAPK12	0.44661647
86	ERBB3	0.44631188
87	CSNK1D	0.44196723
88	RPS6KA3	0.43944303
89	WNK4	0.43805040
90	YES1	0.41597251
91	MAP2K7	0.40265446
92	MUSK	0.40251159
93	NLK	0.39736235
94	JAK2	0.39579693
95	MKNK1	0.36291084
96	GRK7	0.35871895
97	IKBKE	0.35127839
98	CSNK1G1	0.35021350
99	PRKG1	0.34843655
100	PRKCA	0.33785468

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.80590486
2	Morphine addiction_Homo sapiens_hsa05032	2.65341641
3	Circadian entrainment_Homo sapiens_hsa04713	2.49806431
4	Glutamatergic synapse_Homo sapiens_hsa04724	2.34568988
5	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.34245066
6	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.25452915
7	GABAergic synapse_Homo sapiens_hsa04727	2.22972030
8	Taste transduction_Homo sapiens_hsa04742	2.20655747
9	Phototransduction_Homo sapiens_hsa04744	2.18282429
10	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.06357111
11	Insulin secretion_Homo sapiens_hsa04911	2.04202890
12	Salivary secretion_Homo sapiens_hsa04970	2.02728657
13	Olfactory transduction_Homo sapiens_hsa04740	2.01851729
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.00169481
15	Amphetamine addiction_Homo sapiens_hsa05031	1.99619283
16	Long-term potentiation_Homo sapiens_hsa04720	1.76623639
17	Dopaminergic synapse_Homo sapiens_hsa04728	1.71286141
18	Calcium signaling pathway_Homo sapiens_hsa04020	1.65343944
19	Gastric acid secretion_Homo sapiens_hsa04971	1.58137610
20	ABC transporters_Homo sapiens_hsa02010	1.56372374
21	Renin secretion_Homo sapiens_hsa04924	1.52131231
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.48651208
23	Serotonergic synapse_Homo sapiens_hsa04726	1.43474079
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.42133500
25	cAMP signaling pathway_Homo sapiens_hsa04024	1.40178657
26	Long-term depression_Homo sapiens_hsa04730	1.38170653
27	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.38000996
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.34957631
29	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.34576018
30	Circadian rhythm_Homo sapiens_hsa04710	1.32292550
31	Cholinergic synapse_Homo sapiens_hsa04725	1.30637269
32	Cocaine addiction_Homo sapiens_hsa05030	1.28528720
33	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.27258829
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.25564429
35	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.21588560
36	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.21052063
37	Regulation of autophagy_Homo sapiens_hsa04140	1.18578972
38	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.16122444
39	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.15895418
40	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.04312693
41	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.02036668
42	Linoleic acid metabolism_Homo sapiens_hsa00591	1.01377261
43	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.00138329
44	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.97406344
45	Pancreatic secretion_Homo sapiens_hsa04972	0.96873152
46	Type II diabetes mellitus_Homo sapiens_hsa04930	0.95162843
47	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.92747016
48	Collecting duct acid secretion_Homo sapiens_hsa04966	0.85644560
49	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.85327642
50	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.84513314
51	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.84355226
52	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.83427254
53	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.83196595
54	Butanoate metabolism_Homo sapiens_hsa00650	0.82601513
55	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.81257320
56	Oocyte meiosis_Homo sapiens_hsa04114	0.79478545
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.77477219
58	Choline metabolism in cancer_Homo sapiens_hsa05231	0.75576559
59	Estrogen signaling pathway_Homo sapiens_hsa04915	0.75458179
60	Basal transcription factors_Homo sapiens_hsa03022	0.74519274
61	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.69244597
62	Primary immunodeficiency_Homo sapiens_hsa05340	0.67774604
63	MAPK signaling pathway_Homo sapiens_hsa04010	0.66831975
64	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.64197111
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.62651544
66	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.60716840
67	GnRH signaling pathway_Homo sapiens_hsa04912	0.54544992
68	Homologous recombination_Homo sapiens_hsa03440	0.53126936
69	Mineral absorption_Homo sapiens_hsa04978	0.52891837
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52780061
71	Ras signaling pathway_Homo sapiens_hsa04014	0.52033193
72	Tryptophan metabolism_Homo sapiens_hsa00380	0.51732751
73	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.50610946
74	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.50102181
75	Histidine metabolism_Homo sapiens_hsa00340	0.50050531
76	Fanconi anemia pathway_Homo sapiens_hsa03460	0.49747110
77	Propanoate metabolism_Homo sapiens_hsa00640	0.49377489
78	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.48686083
79	mTOR signaling pathway_Homo sapiens_hsa04150	0.47928787
80	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.47774157
81	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.47094472
82	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.46959519
83	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.43807713
84	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.42180491
85	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.40933981
86	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.40699628
87	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.39564531
88	Glioma_Homo sapiens_hsa05214	0.38359033
89	Type I diabetes mellitus_Homo sapiens_hsa04940	0.38004655
90	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.37755564
91	Lysine degradation_Homo sapiens_hsa00310	0.37693031
92	Platelet activation_Homo sapiens_hsa04611	0.37073145
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.36185268
94	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.35469404
95	Selenocompound metabolism_Homo sapiens_hsa00450	0.35231629
96	FoxO signaling pathway_Homo sapiens_hsa04068	0.33892167
97	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.33817788
98	Bile secretion_Homo sapiens_hsa04976	0.33544338
99	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.33460972
100	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.32657363

USP32P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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