ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	7.17911116
2	sperm motility (GO:0030317)	6.41413425
3	fusion of sperm to egg plasma membrane (GO:0007342)	5.62508995
4	sperm capacitation (GO:0048240)	5.55043531
5	negative regulation of Rho protein signal transduction (GO:0035024)	5.44840986
6	plasma membrane fusion (GO:0045026)	4.69228156
7	microtubule depolymerization (GO:0007019)	4.61266525
8	neuronal ion channel clustering (GO:0045161)	4.60821491
9	spermatid development (GO:0007286)	4.59143486
10	sperm-egg recognition (GO:0035036)	4.45746035
11	protein polyglutamylation (GO:0018095)	4.45649855
12	negative regulation of inclusion body assembly (GO:0090084)	4.43154620
13	presynaptic membrane assembly (GO:0097105)	4.35328619
14	calcium ion-dependent exocytosis (GO:0017156)	4.34145868
15	microtubule polymerization or depolymerization (GO:0031109)	4.32811921
16	multicellular organism reproduction (GO:0032504)	4.26881868
17	DNA packaging (GO:0006323)	4.19795915
18	chromosome condensation (GO:0030261)	4.04965009
19	regulation of cilium movement (GO:0003352)	4.00909146
20	protein targeting to Golgi (GO:0000042)	3.99540883
21	limb bud formation (GO:0060174)	3.96552372
22	establishment of protein localization to Golgi (GO:0072600)	3.91078144
23	glomerular basement membrane development (GO:0032836)	3.89775274
24	binding of sperm to zona pellucida (GO:0007339)	3.87336361
25	response to pheromone (GO:0019236)	3.86610548
26	neurotransmitter-gated ion channel clustering (GO:0072578)	3.83904080
27	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.83214593
28	microtubule nucleation (GO:0007020)	3.78487560
29	spermatid nucleus differentiation (GO:0007289)	3.77565124
30	presynaptic membrane organization (GO:0097090)	3.73797291
31	microtubule severing (GO:0051013)	3.71468078
32	regulation of inclusion body assembly (GO:0090083)	3.68624111
33	reproduction (GO:0000003)	3.60875186
34	centriole replication (GO:0007099)	3.60068263
35	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.57751310
36	cell-cell recognition (GO:0009988)	3.53562823
37	postsynaptic membrane organization (GO:0001941)	3.46644300
38	genitalia morphogenesis (GO:0035112)	3.41272448
39	phosphatidylethanolamine metabolic process (GO:0046337)	3.34427463
40	regulation of Rab GTPase activity (GO:0032313)	3.26858023
41	positive regulation of Rab GTPase activity (GO:0032851)	3.26858023
42	sodium ion export (GO:0071436)	3.25635133
43	spermatogenesis (GO:0007283)	3.25508030
44	male gamete generation (GO:0048232)	3.24563905
45	cerebral cortex neuron differentiation (GO:0021895)	3.22429777
46	otic vesicle formation (GO:0030916)	3.14353628
47	cerebral cortex radially oriented cell migration (GO:0021799)	3.13622532
48	appendage development (GO:0048736)	3.11578636
49	limb development (GO:0060173)	3.11578636
50	seminiferous tubule development (GO:0072520)	3.08573362
51	rRNA methylation (GO:0031167)	3.07463186
52	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.03533319
53	negative regulation of fibroblast apoptotic process (GO:2000270)	3.03232078
54	regulation of meiosis I (GO:0060631)	3.02559582
55	single strand break repair (GO:0000012)	3.00305354
56	mesenchymal-epithelial cell signaling (GO:0060638)	2.98540358
57	gamete generation (GO:0007276)	2.98399397
58	C4-dicarboxylate transport (GO:0015740)	2.95212750
59	cell wall macromolecule catabolic process (GO:0016998)	2.94917030
60	embryonic camera-type eye development (GO:0031076)	2.94559924
61	protein localization to Golgi apparatus (GO:0034067)	2.92962277
62	branch elongation of an epithelium (GO:0060602)	2.92920717
63	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.92580951
64	myelination in peripheral nervous system (GO:0022011)	2.92341445
65	peripheral nervous system axon ensheathment (GO:0032292)	2.92341445
66	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition	2.90914080
67	single fertilization (GO:0007338)	2.90608640
68	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.88809352
69	camera-type eye morphogenesis (GO:0048593)	2.82551862
70	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.81774578
71	regulation of microtubule-based movement (GO:0060632)	2.81590911
72	regulation of transcription involved in cell fate commitment (GO:0060850)	2.78352264
73	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	2.78141751
74	cellular ketone body metabolic process (GO:0046950)	2.77012893
75	coronary vasculature morphogenesis (GO:0060977)	2.76292827
76	brain morphogenesis (GO:0048854)	2.73513065
77	segment specification (GO:0007379)	2.73401133
78	ventricular system development (GO:0021591)	2.72454338
79	centriole assembly (GO:0098534)	2.71097221
80	cell wall macromolecule metabolic process (GO:0044036)	2.69871928
81	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.65702987
82	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.64085920
83	RNA destabilization (GO:0050779)	2.63875711
84	vesicle transport along microtubule (GO:0047496)	2.63584856
85	germ cell development (GO:0007281)	2.63475267
86	axis elongation (GO:0003401)	2.63121394
87	cranial nerve morphogenesis (GO:0021602)	2.62552353
88	synaptic vesicle maturation (GO:0016188)	2.61003553
89	musculoskeletal movement (GO:0050881)	2.60450116
90	multicellular organismal movement (GO:0050879)	2.60450116
91	cilium or flagellum-dependent cell motility (GO:0001539)	2.60419405
92	Golgi to endosome transport (GO:0006895)	2.60124760
93	lateral sprouting from an epithelium (GO:0060601)	2.59039834
94	radial glial cell differentiation (GO:0060019)	2.59031032
95	potassium ion import (GO:0010107)	2.58749435
96	neuron cell-cell adhesion (GO:0007158)	2.58615678
97	fertilization (GO:0009566)	2.57619240
98	locomotory exploration behavior (GO:0035641)	2.54949197
99	piRNA metabolic process (GO:0034587)	2.53861611
100	chromatin silencing (GO:0006342)	2.52117005

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.85149043
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.05850294
3	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.73086114
4	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.45583320
5	FUS_26573619_Chip-Seq_HEK293_Human	2.41789607
6	AR_21572438_ChIP-Seq_LNCaP_Human	2.39379687
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.38183271
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.23884363
9	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.06951909
10	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.05505110
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.05131532
12	CBP_20019798_ChIP-Seq_JUKART_Human	1.96551711
13	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.96551711
14	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.94653127
15	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94653127
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.89900972
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.89413111
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.89272497
19	SMAD4_21799915_ChIP-Seq_A2780_Human	1.88603222
20	P300_19829295_ChIP-Seq_ESCs_Human	1.85982975
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.83847577
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.80064533
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.78679779
24	ZNF274_21170338_ChIP-Seq_K562_Hela	1.76115309
25	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.73180781
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.72406418
27	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.71525023
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.70945276
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.68329907
30	AR_25329375_ChIP-Seq_VCAP_Human	1.67670711
31	STAT3_23295773_ChIP-Seq_U87_Human	1.67473332
32	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.61807369
33	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.61619366
34	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.61341989
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60926320
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.60917838
37	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.57256655
38	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.55460126
39	REST_21632747_ChIP-Seq_MESCs_Mouse	1.55405670
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.53940335
41	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52227414
42	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.47460593
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.46509234
44	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.43457416
45	DROSHA_22980978_ChIP-Seq_HELA_Human	1.40289845
46	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39867846
47	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.39201210
48	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.39157246
49	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.38041027
50	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.37620855
51	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.37620855
52	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.35609613
53	RUNX2_22187159_ChIP-Seq_PCA_Human	1.33162651
54	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.32477031
55	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.31221048
56	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.29800847
57	IGF1R_20145208_ChIP-Seq_DFB_Human	1.28831079
58	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.28687299
59	TP53_18474530_ChIP-ChIP_U2OS_Human	1.27877604
60	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.27811794
61	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.26964357
62	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.26908307
63	TCF4_23295773_ChIP-Seq_U87_Human	1.26890339
64	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.26301667
65	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.26295577
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26288132
67	TBL1_22424771_ChIP-Seq_293T_Human	1.25146970
68	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.24880929
69	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.24868824
70	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.24763344
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23258205
72	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.22408123
73	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.21017065
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.20263000
75	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.19960086
76	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.19496653
77	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19388588
78	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.17335570
79	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.16745626
80	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.15845408
81	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.15237649
82	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.14983136
83	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.13831077
84	KDM2B_26808549_Chip-Seq_REH_Human	1.13513033
85	SOX9_26525672_Chip-Seq_HEART_Mouse	1.11926167
86	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.10873157
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08815611
88	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08545982
89	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.08009314
90	NFYB_21822215_ChIP-Seq_K562_Human	1.05553969
91	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05270024
92	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04827688
93	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.03882187
94	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.03766141
95	AR_19668381_ChIP-Seq_PC3_Human	1.00722374
96	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.00593696
97	ETV1_20927104_ChIP-Seq_GIST48_Human	1.00352344
98	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.99028722
99	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98983038
100	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.98225200

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	6.04466424
2	MP0003878_abnormal_ear_physiology	6.04466424
3	MP0005410_abnormal_fertilization	4.76645636
4	MP0002102_abnormal_ear_morphology	3.90050714
5	MP0005257_abnormal_intraocular_pressure	3.36742776
6	MP0004885_abnormal_endolymph	3.10394505
7	MP0005248_abnormal_Harderian_gland	2.87706853
8	MP0004859_abnormal_synaptic_plasticity	2.65964825
9	MP0003880_abnormal_central_pattern	2.35547516
10	MP0005423_abnormal_somatic_nervous	2.32941419
11	MP0004270_analgesia	2.29050130
12	MP0004742_abnormal_vestibular_system	2.22522492
13	MP0003698_abnormal_male_reproductive	2.18054535
14	MP0001486_abnormal_startle_reflex	2.05803917
15	MP0001929_abnormal_gametogenesis	1.83381499
16	MP0001968_abnormal_touch/_nociception	1.81158865
17	MP0005670_abnormal_white_adipose	1.77966423
18	MP0003635_abnormal_synaptic_transmissio	1.77360147
19	MP0000778_abnormal_nervous_system	1.77058977
20	MP0002272_abnormal_nervous_system	1.65359603
21	MP0001485_abnormal_pinna_reflex	1.61680659
22	MP0001963_abnormal_hearing_physiology	1.53169086
23	MP0009745_abnormal_behavioral_response	1.51416358
24	MP0000026_abnormal_inner_ear	1.51383181
25	MP0002132_abnormal_respiratory_system	1.48842984
26	MP0009046_muscle_twitch	1.44570742
27	MP0002822_catalepsy	1.44456877
28	MP0001502_abnormal_circadian_rhythm	1.40985927
29	MP0000955_abnormal_spinal_cord	1.40644729
30	MP0002736_abnormal_nociception_after	1.40477261
31	MP0002734_abnormal_mechanical_nocicepti	1.40039003
32	MP0002184_abnormal_innervation	1.39637408
33	MP0002063_abnormal_learning/memory/cond	1.39271058
34	MP0002064_seizures	1.37116067
35	MP0001984_abnormal_olfaction	1.35163828
36	MP0000613_abnormal_salivary_gland	1.32135884
37	MP0001346_abnormal_lacrimal_gland	1.31984040
38	MP0001661_extended_life_span	1.31589932
39	MP0000569_abnormal_digit_pigmentation	1.31266958
40	MP0005253_abnormal_eye_physiology	1.28125219
41	MP0002572_abnormal_emotion/affect_behav	1.26873203
42	MP0002735_abnormal_chemical_nociception	1.21230855
43	MP0001299_abnormal_eye_distance/	1.20510741
44	MP0008569_lethality_at_weaning	1.16848527
45	MP0004811_abnormal_neuron_physiology	1.16287240
46	MP0003115_abnormal_respiratory_system	1.15623910
47	MP0002161_abnormal_fertility/fecundity	1.15397124
48	MP0001177_atelectasis	1.14954184
49	MP0001501_abnormal_sleep_pattern	1.13992416
50	MP0008789_abnormal_olfactory_epithelium	1.11951951
51	MP0006072_abnormal_retinal_apoptosis	1.11754939
52	MP0002882_abnormal_neuron_morphology	1.11243875
53	MP0002067_abnormal_sensory_capabilities	1.10887478
54	MP0003385_abnormal_body_wall	1.08427330
55	MP0005551_abnormal_eye_electrophysiolog	1.07367376
56	MP0000579_abnormal_nail_morphology	1.05644840
57	MP0002210_abnormal_sex_determination	1.04409327
58	MP0003879_abnormal_hair_cell	1.01970982
59	MP0003755_abnormal_palate_morphology	0.99547737
60	MP0002557_abnormal_social/conspecific_i	0.98533607
61	MP0003938_abnormal_ear_development	0.91867284
62	MP0002234_abnormal_pharynx_morphology	0.88335882
63	MP0003861_abnormal_nervous_system	0.88040247
64	MP0004147_increased_porphyrin_level	0.87702076
65	MP0002152_abnormal_brain_morphology	0.86866772
66	MP0002229_neurodegeneration	0.86588208
67	MP0003942_abnormal_urinary_system	0.85872994
68	MP0001145_abnormal_male_reproductive	0.85459596
69	MP0003119_abnormal_digestive_system	0.84668190
70	MP0000049_abnormal_middle_ear	0.84561049
71	MP0002733_abnormal_thermal_nociception	0.84138771
72	MP0001970_abnormal_pain_threshold	0.81703331
73	MP0000534_abnormal_ureter_morphology	0.81417617
74	MP0005503_abnormal_tendon_morphology	0.81087399
75	MP0000653_abnormal_sex_gland	0.80772729
76	MP0000516_abnormal_urinary_system	0.80768713
77	MP0005367_renal/urinary_system_phenotyp	0.80768713
78	MP0002752_abnormal_somatic_nervous	0.79059924
79	MP0001529_abnormal_vocalization	0.77445896
80	MP0003935_abnormal_craniofacial_develop	0.76000060
81	MP0003646_muscle_fatigue	0.73829036
82	MP0003329_amyloid_beta_deposits	0.73692448
83	MP0001270_distended_abdomen	0.73612207
84	MP0002277_abnormal_respiratory_mucosa	0.73598855
85	MP0000631_abnormal_neuroendocrine_gland	0.72855213
86	MP0002066_abnormal_motor_capabilities/c	0.72133485
87	MP0003633_abnormal_nervous_system	0.69100975
88	MP0002233_abnormal_nose_morphology	0.68967823
89	MP0003631_nervous_system_phenotype	0.67022155
90	MP0005391_vision/eye_phenotype	0.65302689
91	MP0008775_abnormal_heart_ventricle	0.64483630
92	MP0009250_abnormal_appendicular_skeleto	0.64383483
93	MP0000566_synostosis	0.63368488
94	MP0001905_abnormal_dopamine_level	0.61875065
95	MP0004085_abnormal_heartbeat	0.61738219
96	MP0009053_abnormal_anal_canal	0.60135150
97	MP0001348_abnormal_lacrimal_gland	0.58834336
98	MP0010368_abnormal_lymphatic_system	0.57591512
99	MP0004924_abnormal_behavior	0.57253683
100	MP0005386_behavior/neurological_phenoty	0.57253683

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Postural instability (HP:0002172)	4.00261916
2	Hyperkalemia (HP:0002153)	3.84059921
3	Tubulointerstitial nephritis (HP:0001970)	3.50363439
4	Severe visual impairment (HP:0001141)	3.50230883
5	Hypoplastic ischia (HP:0003175)	3.44039698
6	Alacrima (HP:0000522)	3.40124813
7	Abnormality of the ischium (HP:0003174)	3.31002018
8	Bell-shaped thorax (HP:0001591)	3.30056231
9	Recurrent corneal erosions (HP:0000495)	3.28816596
10	Abnormality of incisor morphology (HP:0011063)	3.28547647
11	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.18677011
12	Chronic hepatic failure (HP:0100626)	3.04263615
13	Upper limb muscle weakness (HP:0003484)	2.98730607
14	Aplasia involving bones of the extremities (HP:0009825)	2.95565805
15	Aplasia involving bones of the upper limbs (HP:0009823)	2.95565805
16	Aplasia of the phalanges of the hand (HP:0009802)	2.95565805
17	Mixed hearing impairment (HP:0000410)	2.94750009
18	Decreased lacrimation (HP:0000633)	2.93905881
19	Hand muscle atrophy (HP:0009130)	2.89831180
20	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.74885383
21	Progressive cerebellar ataxia (HP:0002073)	2.72333202
22	Focal motor seizures (HP:0011153)	2.71375228
23	Action tremor (HP:0002345)	2.68757939
24	Retinal dysplasia (HP:0007973)	2.67329359
25	Partial duplication of thumb phalanx (HP:0009944)	2.63050467
26	Volvulus (HP:0002580)	2.57202857
27	Resting tremor (HP:0002322)	2.56821566
28	Glomerulonephritis (HP:0000099)	2.44527644
29	Febrile seizures (HP:0002373)	2.43733820
30	Bony spicule pigmentary retinopathy (HP:0007737)	2.43179623
31	Abnormality of the musculature of the hand (HP:0001421)	2.42090567
32	Hemiparesis (HP:0001269)	2.40654835
33	Attenuation of retinal blood vessels (HP:0007843)	2.40257844
34	Myokymia (HP:0002411)	2.39873005
35	Abnormality of the antihelix (HP:0009738)	2.31175933
36	Nephritis (HP:0000123)	2.30021945
37	Oligodactyly (hands) (HP:0001180)	2.29437238
38	Atonic seizures (HP:0010819)	2.28254941
39	Partial duplication of the phalanx of hand (HP:0009999)	2.27520784
40	Conical tooth (HP:0000698)	2.26335845
41	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	2.25126955
42	Peripheral hypomyelination (HP:0007182)	2.23860550
43	Stage 5 chronic kidney disease (HP:0003774)	2.22486759
44	Hyperventilation (HP:0002883)	2.18762952
45	Impulsivity (HP:0100710)	2.15930434
46	Impaired vibration sensation in the lower limbs (HP:0002166)	2.14073660
47	Intellectual disability, moderate (HP:0002342)	2.12614888
48	Neoplasm of the oral cavity (HP:0100649)	2.12464752
49	Tubulointerstitial abnormality (HP:0001969)	2.09820734
50	Abnormality of the incisor (HP:0000676)	2.09077506
51	Horizontal nystagmus (HP:0000666)	2.08185894
52	Truncal obesity (HP:0001956)	2.07874339
53	Abnormality of the lower motor neuron (HP:0002366)	2.06874792
54	Menstrual irregularities (HP:0000858)	1.99305254
55	Increased corneal curvature (HP:0100692)	1.98741509
56	Keratoconus (HP:0000563)	1.98741509
57	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.98731375
58	Preaxial foot polydactyly (HP:0001841)	1.97749821
59	Midline defect of the nose (HP:0004122)	1.97173858
60	Truncal ataxia (HP:0002078)	1.94320993
61	Amyotrophic lateral sclerosis (HP:0007354)	1.93754029
62	Distal upper limb amyotrophy (HP:0007149)	1.92240373
63	Upper limb amyotrophy (HP:0009129)	1.92240373
64	Cone-rod dystrophy (HP:0000548)	1.90111241
65	Absent/shortened dynein arms (HP:0200106)	1.89658572
66	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.89658572
67	Toxemia of pregnancy (HP:0100603)	1.89262053
68	Cupped ear (HP:0000378)	1.89261394
69	Corneal erosion (HP:0200020)	1.89022404
70	Spastic gait (HP:0002064)	1.88318511
71	Tetraparesis (HP:0002273)	1.87980661
72	Aplasia/Hypoplasia of the lens (HP:0008063)	1.87458222
73	Renal dysplasia (HP:0000110)	1.85842471
74	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.85711403
75	Drooling (HP:0002307)	1.84944626
76	Asymmetric septal hypertrophy (HP:0001670)	1.84333365
77	Hypoplasia of the thymus (HP:0000778)	1.82212772
78	Focal seizures (HP:0007359)	1.82010095
79	Nephronophthisis (HP:0000090)	1.81503667
80	Anterior segment dysgenesis (HP:0007700)	1.80707248
81	Limb hypertonia (HP:0002509)	1.80016518
82	Aqueductal stenosis (HP:0002410)	1.79147413
83	Abnormality of the astrocytes (HP:0100707)	1.79055592
84	Astrocytoma (HP:0009592)	1.79055592
85	Ependymoma (HP:0002888)	1.78146947
86	Abnormality of potassium homeostasis (HP:0011042)	1.75131670
87	Overfolded helix (HP:0000396)	1.74242361
88	Occipital encephalocele (HP:0002085)	1.74045408
89	Abnormality of the renal medulla (HP:0100957)	1.73949542
90	Split foot (HP:0001839)	1.73797304
91	Polyphagia (HP:0002591)	1.71677611
92	Abnormal drinking behavior (HP:0030082)	1.71555768
93	Polydipsia (HP:0001959)	1.71555768
94	Hemiplegia (HP:0002301)	1.71177551
95	Abnormality of the pubic bones (HP:0003172)	1.70638877
96	Intestinal atresia (HP:0011100)	1.69905670
97	Oligodactyly (HP:0012165)	1.68989619
98	Scanning speech (HP:0002168)	1.68274406
99	Short ribs (HP:0000773)	1.68235300
100	Abnormality of macular pigmentation (HP:0008002)	1.65738311

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	4.62126035
2	MARK1	3.50317890
3	PRKD3	3.23835532
4	DDR2	3.03728703
5	FGFR2	2.71672626
6	STK38	2.43222033
7	EPHA4	2.42520164
8	NTRK2	2.36675251
9	PLK2	2.32315381
10	FRK	2.24018367
11	PNCK	2.22556962
12	NTRK3	2.09000970
13	ERBB3	1.92070357
14	PDK2	1.90345704
15	NEK6	1.88619927
16	CASK	1.88408989
17	MAP3K4	1.67604964
18	PKN1	1.58771644
19	STK38L	1.57826422
20	CAMK1G	1.57390814
21	KSR2	1.52387186
22	BMPR1B	1.43153716
23	PHKG2	1.41139377
24	PHKG1	1.41139377
25	TYRO3	1.36836319
26	PAK6	1.36629497
27	DYRK1B	1.29370229
28	NTRK1	1.28093282
29	MKNK2	1.27541739
30	MINK1	1.26163214
31	INSRR	1.25124273
32	PDK1	1.21404002
33	TESK1	1.19355570
34	WNK1	1.16155651
35	BCR	1.12104052
36	MAPK13	1.10658957
37	CDK3	1.09751137
38	MAP4K2	1.08701543
39	TRIM28	1.07324640
40	UHMK1	1.05755134
41	SIK2	1.01953841
42	TAF1	0.94161263
43	STK39	0.92578033
44	PDPK1	0.92267463
45	CAMK2B	0.90056716
46	EPHA3	0.87918453
47	DYRK1A	0.87071362
48	ROCK1	0.85683065
49	WNK3	0.82148844
50	DAPK2	0.81532242
51	MAP2K6	0.81440187
52	FER	0.79742017
53	AKT3	0.78960749
54	RIPK4	0.78573315
55	BRD4	0.71546850
56	RET	0.70528709
57	SGK223	0.69250974
58	SGK494	0.69250974
59	CAMK1D	0.69104754
60	MKNK1	0.67956259
61	MOS	0.67879582
62	PRKCG	0.67374685
63	MAP3K9	0.65281351
64	PRKG1	0.62470459
65	MET	0.62124233
66	TIE1	0.61563686
67	KSR1	0.61353590
68	CDK5	0.60404389
69	MAPK15	0.58706252
70	GSK3B	0.58525332
71	OXSR1	0.58405740
72	PINK1	0.57735752
73	ERBB2	0.55594232
74	PRKCZ	0.53544365
75	ERBB4	0.51820669
76	PRKCE	0.51497789
77	MAPK10	0.51099550
78	CAMK2A	0.50823718
79	CSNK1G2	0.49582976
80	CDK2	0.48394554
81	BRAF	0.47841317
82	CDK1	0.47289309
83	ROCK2	0.47110559
84	CAMK1	0.46241261
85	PAK3	0.45890354
86	CCNB1	0.45864826
87	MAPK8	0.45678356
88	CDK7	0.45158882
89	DYRK2	0.44281033
90	YES1	0.43959295
91	CHEK1	0.43515085
92	CDK8	0.41647937
93	PRKDC	0.40993918
94	PTK2B	0.40869998
95	PRKAA1	0.39783815
96	MAP3K2	0.39412191
97	MAPK14	0.38537147
98	TRPM7	0.38148722
99	JAK2	0.38022720
100	MAP2K7	0.37423657

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.07859760
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.74402133
3	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.69413579
4	Nicotine addiction_Homo sapiens_hsa05033	2.53030356
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.41694806
6	Olfactory transduction_Homo sapiens_hsa04740	2.17954775
7	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.17281121
8	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.92084177
9	Morphine addiction_Homo sapiens_hsa05032	1.81865882
10	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.75667756
11	Circadian entrainment_Homo sapiens_hsa04713	1.68969596
12	Taste transduction_Homo sapiens_hsa04742	1.65630114
13	Glutamatergic synapse_Homo sapiens_hsa04724	1.63518694
14	GABAergic synapse_Homo sapiens_hsa04727	1.61761564
15	Fatty acid metabolism_Homo sapiens_hsa01212	1.61673181
16	Propanoate metabolism_Homo sapiens_hsa00640	1.59594190
17	Butanoate metabolism_Homo sapiens_hsa00650	1.54783015
18	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.52882651
19	Insulin secretion_Homo sapiens_hsa04911	1.50326542
20	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.47317527
21	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.45376119
22	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.42928400
23	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.41709304
24	Salivary secretion_Homo sapiens_hsa04970	1.32147794
25	Basal transcription factors_Homo sapiens_hsa03022	1.30380078
26	Axon guidance_Homo sapiens_hsa04360	1.29538242
27	Lysine degradation_Homo sapiens_hsa00310	1.20242124
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.16833012
29	Amphetamine addiction_Homo sapiens_hsa05031	1.15277815
30	Circadian rhythm_Homo sapiens_hsa04710	1.13704364
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.11368081
32	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.10766023
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.09711011
34	cAMP signaling pathway_Homo sapiens_hsa04024	1.08310800
35	Calcium signaling pathway_Homo sapiens_hsa04020	1.07401613
36	Gastric acid secretion_Homo sapiens_hsa04971	1.05696038
37	Type II diabetes mellitus_Homo sapiens_hsa04930	1.05176872
38	Long-term potentiation_Homo sapiens_hsa04720	1.04649955
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03807255
40	Estrogen signaling pathway_Homo sapiens_hsa04915	1.00192553
41	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.00094078
42	Wnt signaling pathway_Homo sapiens_hsa04310	0.99734519
43	ErbB signaling pathway_Homo sapiens_hsa04012	0.98768963
44	Oocyte meiosis_Homo sapiens_hsa04114	0.98136468
45	Protein digestion and absorption_Homo sapiens_hsa04974	0.97553682
46	ABC transporters_Homo sapiens_hsa02010	0.96236419
47	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.92940493
48	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.91329136
49	Renin secretion_Homo sapiens_hsa04924	0.90212965
50	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.89270565
51	Glioma_Homo sapiens_hsa05214	0.89222663
52	Dopaminergic synapse_Homo sapiens_hsa04728	0.88756684
53	Cocaine addiction_Homo sapiens_hsa05030	0.85868852
54	Long-term depression_Homo sapiens_hsa04730	0.85418964
55	Melanoma_Homo sapiens_hsa05218	0.85283082
56	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.84287450
57	Cholinergic synapse_Homo sapiens_hsa04725	0.82755405
58	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.81018104
59	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.79721597
60	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.73349584
61	Phototransduction_Homo sapiens_hsa04744	0.73231086
62	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.73003179
63	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.70010583
64	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.69115013
65	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.69062772
66	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.68424767
67	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.68007320
68	Fatty acid degradation_Homo sapiens_hsa00071	0.67401615
69	ECM-receptor interaction_Homo sapiens_hsa04512	0.65886569
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.63043368
71	Bile secretion_Homo sapiens_hsa04976	0.62779006
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.62649484
73	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.61552802
74	Endocytosis_Homo sapiens_hsa04144	0.61047722
75	RNA transport_Homo sapiens_hsa03013	0.60342504
76	Serotonergic synapse_Homo sapiens_hsa04726	0.58934050
77	Selenocompound metabolism_Homo sapiens_hsa00450	0.58583978
78	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.57517465
79	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.56750312
80	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.56243797
81	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.56053711
82	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.54829285
83	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.54641577
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53704220
85	Rap1 signaling pathway_Homo sapiens_hsa04015	0.53259123
86	MAPK signaling pathway_Homo sapiens_hsa04010	0.53009641
87	Hippo signaling pathway_Homo sapiens_hsa04390	0.52372493
88	MicroRNAs in cancer_Homo sapiens_hsa05206	0.52301077
89	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.51819191
90	mTOR signaling pathway_Homo sapiens_hsa04150	0.50920093
91	Melanogenesis_Homo sapiens_hsa04916	0.50716218
92	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.49578996
93	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.47783429
94	Choline metabolism in cancer_Homo sapiens_hsa05231	0.47681793
95	Pancreatic secretion_Homo sapiens_hsa04972	0.47357287
96	Tight junction_Homo sapiens_hsa04530	0.44843104
97	Adherens junction_Homo sapiens_hsa04520	0.44526601
98	Glucagon signaling pathway_Homo sapiens_hsa04922	0.44257566
99	mRNA surveillance pathway_Homo sapiens_hsa03015	0.43700333
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.43233299

USP32P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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