USP33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.60026903
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.04538897
3pyrimidine nucleobase catabolic process (GO:0006208)4.87374802
4synaptic vesicle maturation (GO:0016188)4.70581761
5regulation of synaptic vesicle exocytosis (GO:2000300)4.61678478
6synaptic vesicle exocytosis (GO:0016079)4.56138245
7glutamate secretion (GO:0014047)4.54323411
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.47659713
9vocalization behavior (GO:0071625)4.43356652
10neural tube formation (GO:0001841)4.34348026
11locomotory exploration behavior (GO:0035641)4.33056611
12regulation of synaptic vesicle transport (GO:1902803)4.09427657
13nucleobase catabolic process (GO:0046113)4.07420433
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.05294535
15neuron cell-cell adhesion (GO:0007158)4.04597820
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.00257048
17regulation of glutamate receptor signaling pathway (GO:1900449)3.99606105
18protein localization to synapse (GO:0035418)3.97291445
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.94246969
20ionotropic glutamate receptor signaling pathway (GO:0035235)3.91715616
21glutamate receptor signaling pathway (GO:0007215)3.89674645
22neurotransmitter secretion (GO:0007269)3.88945724
23neuronal action potential propagation (GO:0019227)3.84140847
24layer formation in cerebral cortex (GO:0021819)3.73201178
25G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.63246617
26synaptic transmission, glutamatergic (GO:0035249)3.61943210
27positive regulation of synapse maturation (GO:0090129)3.61204408
28neuron recognition (GO:0008038)3.60339158
29axonal fasciculation (GO:0007413)3.59963851
30neuron-neuron synaptic transmission (GO:0007270)3.57353877
31regulation of neuronal synaptic plasticity (GO:0048168)3.56714239
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55808270
33neurotransmitter-gated ion channel clustering (GO:0072578)3.49675481
34long-term memory (GO:0007616)3.48463802
35cellular potassium ion homeostasis (GO:0030007)3.46928831
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.44672879
37exploration behavior (GO:0035640)3.43225560
38dendrite morphogenesis (GO:0048813)3.42281835
39regulation of pigment cell differentiation (GO:0050932)3.40892529
40activation of protein kinase A activity (GO:0034199)3.38471074
41monoubiquitinated protein deubiquitination (GO:0035520)3.34478737
42cerebellar Purkinje cell differentiation (GO:0021702)3.33720195
43dendritic spine morphogenesis (GO:0060997)3.30692036
44neurotransmitter transport (GO:0006836)3.28753475
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.24105648
46behavioral response to nicotine (GO:0035095)3.24089459
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.22180851
48presynaptic membrane assembly (GO:0097105)3.20949246
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20227593
50proline transport (GO:0015824)3.19640105
51regulation of neurotransmitter secretion (GO:0046928)3.19374257
52synaptic vesicle endocytosis (GO:0048488)3.17996412
53establishment of protein localization to Golgi (GO:0072600)3.17704389
54transmission of nerve impulse (GO:0019226)3.17234835
55innervation (GO:0060384)3.15527704
56postsynaptic membrane organization (GO:0001941)3.15500675
57regulation of postsynaptic membrane potential (GO:0060078)3.15110106
58vesicle transport along microtubule (GO:0047496)3.10333597
59positive regulation of developmental pigmentation (GO:0048087)3.08444255
60detection of calcium ion (GO:0005513)3.06143091
61positive regulation of membrane potential (GO:0045838)3.05917638
62gamma-aminobutyric acid transport (GO:0015812)3.05665283
63long-term synaptic potentiation (GO:0060291)3.03192067
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.01460306
65striatum development (GO:0021756)3.01195390
66protein localization to cilium (GO:0061512)3.01077051
67central nervous system projection neuron axonogenesis (GO:0021952)3.00426776
68regulation of synapse structural plasticity (GO:0051823)2.99091561
69synapse assembly (GO:0007416)2.98504948
70chemosensory behavior (GO:0007635)2.96993857
71DNA double-strand break processing (GO:0000729)2.95727761
72protein targeting to Golgi (GO:0000042)2.95017290
73regulation of sarcomere organization (GO:0060297)2.94560875
74regulation of vesicle fusion (GO:0031338)2.94198168
75regulation of synaptic plasticity (GO:0048167)2.93730874
76membrane depolarization during action potential (GO:0086010)2.93205201
77startle response (GO:0001964)2.89442724
78regulation of neurotransmitter levels (GO:0001505)2.89003733
79regulation of neurotransmitter transport (GO:0051588)2.88621127
80cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.87850402
81negative regulation of cytosolic calcium ion concentration (GO:0051481)2.87724468
82fucose catabolic process (GO:0019317)2.87566615
83L-fucose metabolic process (GO:0042354)2.87566615
84L-fucose catabolic process (GO:0042355)2.87566615
85central nervous system neuron axonogenesis (GO:0021955)2.86612898
86presynaptic membrane organization (GO:0097090)2.86288396
87positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.84982155
88negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84501275
89cerebellar granule cell differentiation (GO:0021707)2.84070178
90protein K11-linked deubiquitination (GO:0035871)2.83853589
91retinal cone cell development (GO:0046549)2.83719705
92olfactory bulb development (GO:0021772)2.83703536
93negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.82886939
94negative regulation of translation, ncRNA-mediated (GO:0040033)2.82886939
95regulation of translation, ncRNA-mediated (GO:0045974)2.82886939
96neuromuscular process controlling posture (GO:0050884)2.81515142
97organelle transport along microtubule (GO:0072384)2.81223421
98regulation of synapse maturation (GO:0090128)2.81137425
99negative regulation of dendrite development (GO:2000171)2.81108293
100response to histamine (GO:0034776)2.79858765
101behavioral defense response (GO:0002209)2.79766547
102behavioral fear response (GO:0001662)2.79766547
103mating behavior (GO:0007617)2.79729037
104microtubule anchoring (GO:0034453)2.77573474
105neuromuscular process controlling balance (GO:0050885)2.76455545
106regulation of calcium ion-dependent exocytosis (GO:0017158)2.75128080
107response to auditory stimulus (GO:0010996)2.75113713
108membrane depolarization (GO:0051899)2.74123039
109glycosphingolipid biosynthetic process (GO:0006688)2.73863804
110regulation of rhodopsin mediated signaling pathway (GO:0022400)2.72717280
111negative regulation of DNA-dependent DNA replication (GO:2000104)2.71892743
112regulation of clathrin-mediated endocytosis (GO:2000369)2.71851498
113fear response (GO:0042596)2.71249497
114behavioral response to ethanol (GO:0048149)2.71101304
115response to pheromone (GO:0019236)2.70736373
116membrane hyperpolarization (GO:0060081)2.70470453
117regulation of dendritic spine morphogenesis (GO:0061001)2.70418028
118cilium morphogenesis (GO:0060271)2.69395188
119cell communication by electrical coupling (GO:0010644)2.69052809
120cAMP catabolic process (GO:0006198)2.68917099
121rhodopsin mediated signaling pathway (GO:0016056)2.68453615
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.67726374
123positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.67410756
124positive regulation of neurotransmitter transport (GO:0051590)2.67361772
125auditory behavior (GO:0031223)2.66612412
126synaptic transmission (GO:0007268)2.66409843
127positive regulation of synaptic transmission, GABAergic (GO:0032230)2.66229546
128intraciliary transport (GO:0042073)2.66197562
129cell migration in hindbrain (GO:0021535)2.65183673
130sodium ion export (GO:0071436)2.64937822
131kynurenine metabolic process (GO:0070189)2.63384010
132replication fork processing (GO:0031297)2.63003893
133cilium organization (GO:0044782)2.62664206
134RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62382897
135neuronal action potential (GO:0019228)2.61822581
136cilium assembly (GO:0042384)2.60798063
137reflex (GO:0060004)2.60672840
138prenylation (GO:0097354)2.59058331
139protein prenylation (GO:0018342)2.59058331
140detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.57476339
141cyclic nucleotide catabolic process (GO:0009214)2.56937776
142nonmotile primary cilium assembly (GO:0035058)2.56142203
143photoreceptor cell maintenance (GO:0045494)2.55762485
144epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53908723
145detection of light stimulus involved in sensory perception (GO:0050962)2.52113530
146detection of light stimulus involved in visual perception (GO:0050908)2.52113530
147sympathetic nervous system development (GO:0048485)2.52022109
148head development (GO:0060322)2.49439339
149interkinetic nuclear migration (GO:0022027)2.49351881
150negative regulation of neurotransmitter transport (GO:0051589)2.49146688
151serotonin metabolic process (GO:0042428)2.47298997
152cytoplasmic mRNA processing body assembly (GO:0033962)2.47173241
153indolalkylamine metabolic process (GO:0006586)2.45097566
154regulation of meiosis I (GO:0060631)2.45061755
155cilium or flagellum-dependent cell motility (GO:0001539)2.43737410
156negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.42173039
157atrial cardiac muscle cell action potential (GO:0086014)2.41455482
158retinal ganglion cell axon guidance (GO:0031290)2.41384731
159negative regulation of mast cell activation (GO:0033004)2.40649560
160nerve growth factor signaling pathway (GO:0038180)2.40103475
161reciprocal meiotic recombination (GO:0007131)2.40065319
162reciprocal DNA recombination (GO:0035825)2.40065319
163negative regulation of DNA recombination (GO:0045910)2.38604556
164inner ear receptor stereocilium organization (GO:0060122)2.37336531
165phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.36071608
166protein polyglutamylation (GO:0018095)2.35833437
167regulation of DNA endoreduplication (GO:0032875)2.35264816
168rRNA catabolic process (GO:0016075)2.30858094
169Golgi to endosome transport (GO:0006895)2.29931872
170cerebral cortex radially oriented cell migration (GO:0021799)2.29425426

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.87377634
2GBX2_23144817_ChIP-Seq_PC3_Human3.90270547
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66469485
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61125734
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52535886
6REST_21632747_ChIP-Seq_MESCs_Mouse2.45946754
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42857016
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.19040254
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15190357
10* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.13540055
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11462475
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11462475
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08644144
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08619090
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07636270
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04590851
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.04331917
18DROSHA_22980978_ChIP-Seq_HELA_Human2.03977812
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03567275
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01171143
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97041997
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93685441
23* RARB_27405468_Chip-Seq_BRAIN_Mouse1.93249434
24SMAD4_21799915_ChIP-Seq_A2780_Human1.92818714
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85207039
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.85200339
27TAF15_26573619_Chip-Seq_HEK293_Human1.85143466
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83710754
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83059380
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.82436215
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.80086567
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.73570297
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72930184
34* P300_19829295_ChIP-Seq_ESCs_Human1.71552550
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71446643
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.69149715
37ZNF274_21170338_ChIP-Seq_K562_Hela1.67694282
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66994552
39* STAT3_23295773_ChIP-Seq_U87_Human1.64601217
40AR_21572438_ChIP-Seq_LNCaP_Human1.64062846
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62342524
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60090695
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55409739
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54290787
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53891334
46CBP_20019798_ChIP-Seq_JUKART_Human1.53891334
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53238185
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.51095951
49IGF1R_20145208_ChIP-Seq_DFB_Human1.50330281
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49909659
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49561815
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.48003081
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46697742
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46623573
55AR_25329375_ChIP-Seq_VCAP_Human1.43738580
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43692503
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.43605687
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.43244578
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.42922293
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42425121
61FUS_26573619_Chip-Seq_HEK293_Human1.41177671
62AHR_22903824_ChIP-Seq_MCF-7_Human1.40576242
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39019461
64TCF4_23295773_ChIP-Seq_U87_Human1.35537962
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35345945
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.32642860
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32524758
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32038697
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31672991
70P53_22387025_ChIP-Seq_ESCs_Mouse1.30683483
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30637259
72AR_19668381_ChIP-Seq_PC3_Human1.29742293
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29323373
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29124895
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28652020
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.27996907
77BCAT_22108803_ChIP-Seq_LS180_Human1.27740741
78RUNX2_22187159_ChIP-Seq_PCA_Human1.25016018
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24747533
80IRF1_19129219_ChIP-ChIP_H3396_Human1.24495098
81* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23420315
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23184481
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22833934
84TCF4_22108803_ChIP-Seq_LS180_Human1.21959812
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.19928061
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19833712
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.19777753
88* RNF2_27304074_Chip-Seq_NSC_Mouse1.18742663
89ER_23166858_ChIP-Seq_MCF-7_Human1.18739907
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18634472
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17969503
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.16696598
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16578337
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.16168400
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15752363
96SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15264839
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14899089
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14880864
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12333427
100JUN_21703547_ChIP-Seq_K562_Human1.11604300
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11422552
102NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11422552
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11313315
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11216731
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11216731
106SALL1_21062744_ChIP-ChIP_HESCs_Human1.11004226
107KDM2B_26808549_Chip-Seq_REH_Human1.10996119
108TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10829503
109RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09903409
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09610812
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09589435
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09260017
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09091791
114SMAD4_21741376_ChIP-Seq_EPCs_Human1.08155193
115TP53_16413492_ChIP-PET_HCT116_Human1.07523796
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06965764
117P300_18555785_Chip-Seq_ESCs_Mouse1.06940893
118SOX2_19829295_ChIP-Seq_ESCs_Human1.06861389
119NANOG_19829295_ChIP-Seq_ESCs_Human1.06861389
120STAT3_18555785_Chip-Seq_ESCs_Mouse1.06422887
121OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06326451
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03928545
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03084708
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02645279
125E2F1_18555785_Chip-Seq_ESCs_Mouse1.02368432
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.01833375
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99799125
128WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99605425
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99047251
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98951925
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.98249622
132* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97145400
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.96667198
134RXR_22108803_ChIP-Seq_LS180_Human0.95910322
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.95874443
136CMYC_18555785_Chip-Seq_ESCs_Mouse0.92936816
137VDR_22108803_ChIP-Seq_LS180_Human0.92772977
138MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92689158
139EWS_26573619_Chip-Seq_HEK293_Human0.92357764

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.10569669
2MP0003880_abnormal_central_pattern4.23581826
3MP0004270_analgesia3.64754654
4MP0003635_abnormal_synaptic_transmissio3.62270703
5MP0008057_abnormal_DNA_replication3.04510141
6MP0009745_abnormal_behavioral_response2.87639604
7MP0002063_abnormal_learning/memory/cond2.87124764
8MP0001984_abnormal_olfaction2.75359570
9MP0002734_abnormal_mechanical_nocicepti2.70129899
10MP0008877_abnormal_DNA_methylation2.66832451
11MP0002102_abnormal_ear_morphology2.65204524
12MP0002064_seizures2.62544555
13MP0009046_muscle_twitch2.56459118
14MP0005551_abnormal_eye_electrophysiolog2.50332825
15MP0002572_abnormal_emotion/affect_behav2.47849198
16MP0001968_abnormal_touch/_nociception2.44524421
17MP0001486_abnormal_startle_reflex2.44164429
18MP0005423_abnormal_somatic_nervous2.40421305
19MP0002272_abnormal_nervous_system2.33717729
20MP0009780_abnormal_chondrocyte_physiolo2.30673926
21MP0002909_abnormal_adrenal_gland2.15482252
22MP0005646_abnormal_pituitary_gland2.12909272
23MP0010386_abnormal_urinary_bladder2.03757000
24MP0003787_abnormal_imprinting1.97506619
25MP0002067_abnormal_sensory_capabilities1.94737183
26MP0002735_abnormal_chemical_nociception1.92934477
27MP0001501_abnormal_sleep_pattern1.92461183
28MP0001440_abnormal_grooming_behavior1.90430047
29MP0002733_abnormal_thermal_nociception1.86105206
30MP0002184_abnormal_innervation1.84163010
31MP0000778_abnormal_nervous_system1.80866336
32MP0000569_abnormal_digit_pigmentation1.80479506
33MP0002822_catalepsy1.79192146
34MP0006072_abnormal_retinal_apoptosis1.78882760
35MP0004147_increased_porphyrin_level1.76183546
36MP0001970_abnormal_pain_threshold1.75271325
37MP0004885_abnormal_endolymph1.68911685
38MP0006276_abnormal_autonomic_nervous1.66156544
39MP0002557_abnormal_social/conspecific_i1.65175978
40MP0001188_hyperpigmentation1.60534373
41MP0002638_abnormal_pupillary_reflex1.59504837
42MP0002736_abnormal_nociception_after1.58914114
43MP0000427_abnormal_hair_cycle1.58007768
44MP0004924_abnormal_behavior1.57479810
45MP0005386_behavior/neurological_phenoty1.57479810
46MP0002009_preneoplasia1.55672972
47MP0008569_lethality_at_weaning1.49773824
48MP0002882_abnormal_neuron_morphology1.49546090
49MP0005253_abnormal_eye_physiology1.49245549
50MP0004811_abnormal_neuron_physiology1.44364045
51MP0003122_maternal_imprinting1.43840237
52MP0005645_abnormal_hypothalamus_physiol1.39914552
53MP0000955_abnormal_spinal_cord1.38423450
54MP0003195_calcinosis1.36982427
55MP0001502_abnormal_circadian_rhythm1.36535868
56MP0003329_amyloid_beta_deposits1.35939636
57MP0003646_muscle_fatigue1.35629664
58MP0004043_abnormal_pH_regulation1.33859290
59MP0003183_abnormal_peptide_metabolism1.32082012
60MP0002229_neurodegeneration1.31739834
61MP0000013_abnormal_adipose_tissue1.30079064
62MP0002066_abnormal_motor_capabilities/c1.27101366
63MP0003879_abnormal_hair_cell1.27055086
64MP0002751_abnormal_autonomic_nervous1.25606726
65MP0001177_atelectasis1.24460404
66MP0003283_abnormal_digestive_organ1.23686168
67MP0003937_abnormal_limbs/digits/tail_de1.20972309
68MP0001529_abnormal_vocalization1.16245707
69MP0002876_abnormal_thyroid_physiology1.13486320
70MP0005187_abnormal_penis_morphology1.11947416
71MP0005499_abnormal_olfactory_system1.10468281
72MP0005394_taste/olfaction_phenotype1.10468281
73MP0000647_abnormal_sebaceous_gland1.08972806
74MP0008058_abnormal_DNA_repair1.05622011
75MP0006292_abnormal_olfactory_placode1.05443951
76MP0002090_abnormal_vision1.05347321
77MP0005171_absent_coat_pigmentation1.04930597
78MP0000631_abnormal_neuroendocrine_gland1.04723313
79MP0003633_abnormal_nervous_system1.04665976
80MP0002152_abnormal_brain_morphology1.03513969
81MP0005174_abnormal_tail_pigmentation1.02799794
82MP0004742_abnormal_vestibular_system1.01983275
83MP0003119_abnormal_digestive_system1.00919000
84MP0000372_irregular_coat_pigmentation1.00181458
85MP0009697_abnormal_copulation0.99927038
86MP0002752_abnormal_somatic_nervous0.98810800
87MP0000383_abnormal_hair_follicle0.95853100
88MP0002069_abnormal_eating/drinking_beha0.95470380
89MP0004133_heterotaxia0.95222861
90MP0003567_abnormal_fetal_cardiomyocyte0.94173833
91MP0002234_abnormal_pharynx_morphology0.92645745
92MP0003136_yellow_coat_color0.90916204
93MP0001485_abnormal_pinna_reflex0.87972629
94MP0005391_vision/eye_phenotype0.87309191
95MP0003631_nervous_system_phenotype0.86851003
96MP0001944_abnormal_pancreas_morphology0.86831656
97MP0005195_abnormal_posterior_eye0.86785367
98MP0002693_abnormal_pancreas_physiology0.85164244
99MP0001324_abnormal_eye_pigmentation0.85134839
100MP0001299_abnormal_eye_distance/0.84738452
101MP0001963_abnormal_hearing_physiology0.84633985
102MP0002095_abnormal_skin_pigmentation0.83829304
103MP0001293_anophthalmia0.82850044
104MP0005379_endocrine/exocrine_gland_phen0.82818898
105MP0002233_abnormal_nose_morphology0.81745620
106MP0004130_abnormal_muscle_cell0.81707801
107MP0004145_abnormal_muscle_electrophysio0.81206380
108MP0005535_abnormal_body_temperature0.80387460
109MP0003137_abnormal_impulse_conducting0.79919456
110MP0002938_white_spotting0.79891017
111MP0004858_abnormal_nervous_system0.79872902
112MP0003045_fibrosis0.79789649
113MP0003634_abnormal_glial_cell0.79694235
114MP0003698_abnormal_male_reproductive0.79429785
115MP0002653_abnormal_ependyma_morphology0.79368521
116MP0003121_genomic_imprinting0.79235292
117MP0001905_abnormal_dopamine_level0.78585017
118MP0001986_abnormal_taste_sensitivity0.76694850
119MP0003123_paternal_imprinting0.74411790
120MP0003632_abnormal_nervous_system0.73141785
121MP0004142_abnormal_muscle_tone0.70907637
122MP0010234_abnormal_vibrissa_follicle0.70332414
123MP0003690_abnormal_glial_cell0.70250400
124MP0008961_abnormal_basal_metabolism0.69553347
125MP0002837_dystrophic_cardiac_calcinosis0.66122805
126MP0004085_abnormal_heartbeat0.66076695
127MP0000462_abnormal_digestive_system0.64089717
128MP0002078_abnormal_glucose_homeostasis0.62755523
129MP0004215_abnormal_myocardial_fiber0.61956383
130MP0003890_abnormal_embryonic-extraembry0.60818140
131MP0003868_abnormal_feces_composition0.59729752
132MP0001664_abnormal_digestion0.58568574
133MP0003953_abnormal_hormone_level0.57272403

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.18344319
2Focal seizures (HP:0007359)4.85355271
3Atonic seizures (HP:0010819)4.50602538
4Visual hallucinations (HP:0002367)4.44544635
5Febrile seizures (HP:0002373)4.44140924
6Epileptic encephalopathy (HP:0200134)4.39969097
7Absence seizures (HP:0002121)3.96511042
8Congenital stationary night blindness (HP:0007642)3.87416737
9Progressive cerebellar ataxia (HP:0002073)3.78036898
10Myokymia (HP:0002411)3.72464397
11Dialeptic seizures (HP:0011146)3.64205073
12Pancreatic cysts (HP:0001737)3.40844039
13Generalized tonic-clonic seizures (HP:0002069)3.33243509
14Bony spicule pigmentary retinopathy (HP:0007737)3.32358356
15Drooling (HP:0002307)3.31154427
16Excessive salivation (HP:0003781)3.31154427
17Molar tooth sign on MRI (HP:0002419)3.31107824
18Abnormality of midbrain morphology (HP:0002418)3.31107824
19Action tremor (HP:0002345)3.27275583
20Nephronophthisis (HP:0000090)3.13365094
21Central scotoma (HP:0000603)3.11317197
22Broad-based gait (HP:0002136)3.06126528
23Volvulus (HP:0002580)3.03670892
24Abnormality of the renal cortex (HP:0011035)2.97880062
25Aplasia/Hypoplasia of the tibia (HP:0005772)2.97638420
26Hyperventilation (HP:0002883)2.93234086
27Truncal ataxia (HP:0002078)2.92066576
28Supranuclear gaze palsy (HP:0000605)2.90636974
29True hermaphroditism (HP:0010459)2.90089134
30Abnormality of macular pigmentation (HP:0008002)2.83259542
31Abnormality of the renal medulla (HP:0100957)2.80431229
32Gaze-evoked nystagmus (HP:0000640)2.77938580
33Protruding tongue (HP:0010808)2.77770007
34Epileptiform EEG discharges (HP:0011182)2.74400751
35EEG with generalized epileptiform discharges (HP:0011198)2.68456067
36Poor eye contact (HP:0000817)2.63508023
37Renal cortical cysts (HP:0000803)2.62431650
38Dysdiadochokinesis (HP:0002075)2.62140293
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60154904
40Abnormality of alanine metabolism (HP:0010916)2.60154904
41Hyperalaninemia (HP:0003348)2.60154904
42Abnormal rod and cone electroretinograms (HP:0008323)2.59034441
43Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.57996697
44Inability to walk (HP:0002540)2.56745197
45Hypsarrhythmia (HP:0002521)2.50292827
46Absent speech (HP:0001344)2.50089736
47Impaired social interactions (HP:0000735)2.49740232
48Abnormal social behavior (HP:0012433)2.49740232
49Generalized hypopigmentation of hair (HP:0011358)2.49414008
50Depression (HP:0000716)2.46564171
51Genetic anticipation (HP:0003743)2.44762245
52Ankle clonus (HP:0011448)2.43774230
53Poor coordination (HP:0002370)2.41353687
54Gait imbalance (HP:0002141)2.39646761
55Abnormality of the lower motor neuron (HP:0002366)2.38768396
56Colon cancer (HP:0003003)2.38321400
57Progressive inability to walk (HP:0002505)2.37192267
58Urinary bladder sphincter dysfunction (HP:0002839)2.36274265
59Abnormality of salivation (HP:0100755)2.32284404
60Impaired smooth pursuit (HP:0007772)2.32264804
61Agitation (HP:0000713)2.30719595
62Postural instability (HP:0002172)2.30122273
63Impaired vibration sensation in the lower limbs (HP:0002166)2.29013771
64Blue irides (HP:0000635)2.28870247
65Lissencephaly (HP:0001339)2.28650124
66Dysmetria (HP:0001310)2.25053395
67Anxiety (HP:0000739)2.22394827
68Scotoma (HP:0000575)2.22272531
69Scanning speech (HP:0002168)2.19869249
70Spastic gait (HP:0002064)2.19689791
71Intestinal atresia (HP:0011100)2.19105634
72Tubulointerstitial nephritis (HP:0001970)2.18998602
73Pheochromocytoma (HP:0002666)2.13358960
74Amyotrophic lateral sclerosis (HP:0007354)2.12831722
75Short foot (HP:0001773)2.12494446
76Fair hair (HP:0002286)2.11431976
77Mutism (HP:0002300)2.11373697
78Decreased circulating renin level (HP:0003351)2.10838476
79Insidious onset (HP:0003587)2.10253255
80Termporal pattern (HP:0011008)2.10253255
81Ventricular fibrillation (HP:0001663)2.09976531
82Pachygyria (HP:0001302)2.09789516
83Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09763156
84Abnormal eating behavior (HP:0100738)2.07785882
85Thyroid-stimulating hormone excess (HP:0002925)2.05570496
86Amblyopia (HP:0000646)2.04109941
87Type II diabetes mellitus (HP:0005978)2.03322313
88Congenital primary aphakia (HP:0007707)2.02507713
89Abnormality of ocular smooth pursuit (HP:0000617)2.02405132
90Cortical dysplasia (HP:0002539)2.02022138
91Bifid tongue (HP:0010297)2.01815967
92Broad foot (HP:0001769)2.01803237
93Medial flaring of the eyebrow (HP:0010747)1.99037656
94Abolished electroretinogram (ERG) (HP:0000550)1.98518991
95Oligodactyly (hands) (HP:0001180)1.97903794
96Abnormality of the corticospinal tract (HP:0002492)1.97668122
97Neoplasm of the adrenal cortex (HP:0100641)1.94867937
98Stomach cancer (HP:0012126)1.94635621
99Intention tremor (HP:0002080)1.94349814
100Chorioretinal atrophy (HP:0000533)1.94054584
101Papillary thyroid carcinoma (HP:0002895)1.93397348
102Tubular atrophy (HP:0000092)1.92942124
103Specific learning disability (HP:0001328)1.92163632
104Postaxial foot polydactyly (HP:0001830)1.92008777
105Cystic liver disease (HP:0006706)1.91287121
106Bradykinesia (HP:0002067)1.90984946
107Polyphagia (HP:0002591)1.88880257
108Lower limb muscle weakness (HP:0007340)1.88732710
109Neuroendocrine neoplasm (HP:0100634)1.88226754
110Short tibia (HP:0005736)1.87940734
111Aplasia/Hypoplasia of the tongue (HP:0010295)1.87743162
112Cerebral inclusion bodies (HP:0100314)1.87538633
113Decreased central vision (HP:0007663)1.87077037
114Postaxial hand polydactyly (HP:0001162)1.87049017
115Small hand (HP:0200055)1.86620576
116Widely spaced teeth (HP:0000687)1.86461891
117Dyschromatopsia (HP:0007641)1.85254758
118Narrow forehead (HP:0000341)1.84813046
119Abnormality of the labia minora (HP:0012880)1.84493023
120Dyskinesia (HP:0100660)1.83494061
121Hepatoblastoma (HP:0002884)1.82896752
122Neurofibrillary tangles (HP:0002185)1.82868600
123Genital tract atresia (HP:0001827)1.82197841
124Cerebellar dysplasia (HP:0007033)1.81955727
125Status epilepticus (HP:0002133)1.81152056
126Limb dystonia (HP:0002451)1.80759916
127Nephrogenic diabetes insipidus (HP:0009806)1.80545625
128Hypoplastic iliac wings (HP:0002866)1.80405924
129Hemiparesis (HP:0001269)1.80155408
130Pancreatic fibrosis (HP:0100732)1.79661988
131Exotropia (HP:0000577)1.79458651
132Degeneration of the lateral corticospinal tracts (HP:0002314)1.79329262
133Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79329262
134Tubulointerstitial abnormality (HP:0001969)1.79153876
135Astigmatism (HP:0000483)1.79047774
136Attenuation of retinal blood vessels (HP:0007843)1.78660899
137Fetal akinesia sequence (HP:0001989)1.77851904
138Diplopia (HP:0000651)1.75688356
139Abnormality of binocular vision (HP:0011514)1.75688356
140Thyroiditis (HP:0100646)1.75424089
141Hyperthyroidism (HP:0000836)1.74289862
142Type II lissencephaly (HP:0007260)1.74184726
143Restlessness (HP:0000711)1.73132397
144Stereotypic behavior (HP:0000733)1.73043769
145Retinitis pigmentosa (HP:0000510)1.71982402
146Truncal obesity (HP:0001956)1.71412779
147Chronic hepatic failure (HP:0100626)1.70991102
148Clonus (HP:0002169)1.70448748
149Urinary urgency (HP:0000012)1.70338670
150Papilledema (HP:0001085)1.70276309
151Vaginal atresia (HP:0000148)1.70180626
152Gout (HP:0001997)1.69685222
153Thyroid carcinoma (HP:0002890)1.69599005
154Congenital hepatic fibrosis (HP:0002612)1.69209337
155Generalized myoclonic seizures (HP:0002123)1.68020947
156Micropenis (HP:0000054)1.67561961
157Cupped ear (HP:0000378)1.66979000
158Labial hypoplasia (HP:0000066)1.66927545
159Hypoplastic labia majora (HP:0000059)1.66519663
160Inappropriate behavior (HP:0000719)1.66307190
161Hypothermia (HP:0002045)1.65985762
162Preaxial hand polydactyly (HP:0001177)1.65785822
163Glioma (HP:0009733)1.65442943

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.86903505
2MARK13.41359928
3EPHA43.17432590
4MAP3K43.02593882
5MAP3K92.94510765
6ACVR1B2.75484372
7MAP2K72.58406030
8AKT32.50923347
9BMPR1B2.41727355
10CASK2.37516588
11TRIM282.15022887
12MINK12.10466112
13INSRR2.07018265
14MAP4K22.04217029
15DAPK21.93895417
16MKNK21.85848593
17TNIK1.81534831
18MAP2K41.78540484
19PAK61.74302485
20CAMKK21.70239839
21RIPK41.70086688
22NTRK11.68279996
23ZAK1.58251345
24NTRK21.56576032
25PNCK1.55004436
26CAMKK11.51998455
27STK38L1.47070875
28PLK21.47061055
29KSR11.44231361
30MKNK11.42615398
31MAPK131.40466241
32CDK51.37720643
33SGK21.36926023
34SIK21.35093652
35MAP3K21.32454507
36STK381.32002934
37SGK4941.30945895
38SGK2231.30945895
39KSR21.30128023
40EPHA31.29284357
41PRKCG1.27945427
42FRK1.25871281
43CSNK1G11.22656173
44PRKD31.21371631
45PAK31.20240107
46WNK31.17355943
47GRK11.17295215
48CAMK1G1.17032521
49GRK51.16962410
50BRD41.06897881
51PRPF4B1.05740369
52SGK31.05228002
53LATS11.02239719
54CSNK1G20.98950270
55DYRK20.97217400
56PINK10.94956024
57OXSR10.91627661
58PLK40.90918913
59DYRK1A0.89690032
60FER0.89337350
61PRKCE0.88881661
62LATS20.87534866
63SGK10.86091053
64CAMK2A0.86090729
65PHKG10.85332155
66PHKG20.85332155
67UHMK10.83480424
68CAMK2B0.83400899
69STK30.80618772
70NEK60.79253818
71MAP3K120.79031948
72FGFR20.77408316
73DAPK10.75051226
74BRSK20.74221831
75RET0.73151434
76MAP3K130.72520226
77PRKCH0.71591279
78ADRBK10.68298524
79LMTK20.67893440
80DYRK30.67503725
81WNK10.65367226
82CSNK1A1L0.65196675
83CAMK1D0.65129001
84CDC42BPA0.63815876
85ERBB20.62695028
86BMPR20.61097386
87ADRBK20.60163277
88PIK3CA0.59918089
89PRKCZ0.59835619
90TEC0.59195310
91NLK0.58468649
92STK110.58064816
93CDK30.56564241
94CAMK10.56263516
95PRKAA10.56229103
96CDK190.55605882
97RPS6KA30.55169060
98MAPK100.54803122
99EIF2AK30.54738148
100RPS6KA40.54019088
101CAMK2D0.53064362
102SRPK10.53033417
103BCR0.52550253
104STK390.52326878
105PLK30.51472358
106WNK40.51458177
107NUAK10.51413749
108TGFBR10.51374200
109CSNK1D0.50927694
110ERBB30.48230619
111ATM0.47956574
112MAP2K10.46776006
113CDK180.46032131
114PTK2B0.44892675
115CDK150.43720907
116CDK140.43499022
117HIPK20.43490695
118NME10.42932112
119CCNB10.42578631
120MARK20.42043536
121ATR0.41931489
122PRKCB0.41817706
123TAOK30.41422909
124CSNK1G30.41118360
125MAP3K60.40619099
126CAMK2G0.40535539
127PRKACB0.39878028
128ARAF0.39366076
129YES10.38875878
130CSNK1E0.37984698
131PDPK10.37980502
132RAF10.37937979
133MAP3K10.37209673
134SCYL20.37068122
135CAMK40.36259446
136PRKAA20.35452876
137PRKACA0.34856489
138PLK10.31873473
139PKN10.31676519
140PRKG10.30519170
141PDK20.30109239
142TXK0.27707042

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.48968665
2Phototransduction_Homo sapiens_hsa047443.05405446
3Synaptic vesicle cycle_Homo sapiens_hsa047213.03816126
4Olfactory transduction_Homo sapiens_hsa047402.65428716
5GABAergic synapse_Homo sapiens_hsa047272.64686324
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60671925
7Insulin secretion_Homo sapiens_hsa049112.44898891
8Circadian entrainment_Homo sapiens_hsa047132.43917935
9Morphine addiction_Homo sapiens_hsa050322.42119406
10Glutamatergic synapse_Homo sapiens_hsa047242.40211599
11Long-term potentiation_Homo sapiens_hsa047202.33863571
12Amphetamine addiction_Homo sapiens_hsa050312.22984072
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16987557
14Non-homologous end-joining_Homo sapiens_hsa034502.14850906
15Taste transduction_Homo sapiens_hsa047422.12332209
16Propanoate metabolism_Homo sapiens_hsa006402.02844871
17Dopaminergic synapse_Homo sapiens_hsa047282.02741670
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00228678
19Salivary secretion_Homo sapiens_hsa049701.88730966
20Cholinergic synapse_Homo sapiens_hsa047251.80133045
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75124880
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68005946
23Cocaine addiction_Homo sapiens_hsa050301.65674937
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.63348211
25Serotonergic synapse_Homo sapiens_hsa047261.61592830
26Renin secretion_Homo sapiens_hsa049241.58919575
27Type II diabetes mellitus_Homo sapiens_hsa049301.56388106
28Gastric acid secretion_Homo sapiens_hsa049711.55578772
29Fanconi anemia pathway_Homo sapiens_hsa034601.54632233
30Collecting duct acid secretion_Homo sapiens_hsa049661.51042965
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47518381
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46730145
33Ether lipid metabolism_Homo sapiens_hsa005651.46662989
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41887852
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40906083
36Long-term depression_Homo sapiens_hsa047301.40557338
37Linoleic acid metabolism_Homo sapiens_hsa005911.36928614
38Oxytocin signaling pathway_Homo sapiens_hsa049211.35271320
39Basal transcription factors_Homo sapiens_hsa030221.34403167
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32853720
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31935946
42Calcium signaling pathway_Homo sapiens_hsa040201.30062637
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27655294
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27580866
45GnRH signaling pathway_Homo sapiens_hsa049121.27345382
46ABC transporters_Homo sapiens_hsa020101.24710961
47Vibrio cholerae infection_Homo sapiens_hsa051101.20240618
48cAMP signaling pathway_Homo sapiens_hsa040241.18082231
49Selenocompound metabolism_Homo sapiens_hsa004501.16863583
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13846981
51beta-Alanine metabolism_Homo sapiens_hsa004101.11443061
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09582335
53Tryptophan metabolism_Homo sapiens_hsa003801.09125078
54Gap junction_Homo sapiens_hsa045401.08071846
55Estrogen signaling pathway_Homo sapiens_hsa049151.07085820
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06347951
57Pancreatic secretion_Homo sapiens_hsa049721.05475844
58RNA degradation_Homo sapiens_hsa030181.04281737
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03396699
60Circadian rhythm_Homo sapiens_hsa047101.01763580
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97880072
62ErbB signaling pathway_Homo sapiens_hsa040120.96124868
63Dorso-ventral axis formation_Homo sapiens_hsa043200.95195501
64Protein export_Homo sapiens_hsa030600.94694119
65Homologous recombination_Homo sapiens_hsa034400.94548608
66Axon guidance_Homo sapiens_hsa043600.93479082
67Thyroid hormone synthesis_Homo sapiens_hsa049180.91090806
68Fatty acid biosynthesis_Homo sapiens_hsa000610.90728790
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89886571
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.89339038
71Melanogenesis_Homo sapiens_hsa049160.87492480
72Steroid biosynthesis_Homo sapiens_hsa001000.86520280
73Glioma_Homo sapiens_hsa052140.86069839
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.85243037
75Inositol phosphate metabolism_Homo sapiens_hsa005620.84872064
76Oocyte meiosis_Homo sapiens_hsa041140.81208624
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79416393
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77654590
79Regulation of autophagy_Homo sapiens_hsa041400.76931284
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.75309356
81Glycerolipid metabolism_Homo sapiens_hsa005610.75122445
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74635757
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74080432
84Vitamin B6 metabolism_Homo sapiens_hsa007500.72463766
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72407180
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71862691
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.70370550
88Glucagon signaling pathway_Homo sapiens_hsa049220.69366011
89Choline metabolism in cancer_Homo sapiens_hsa052310.67905116
90mTOR signaling pathway_Homo sapiens_hsa041500.65603599
91Fatty acid metabolism_Homo sapiens_hsa012120.62386955
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62251324
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.62129102
94Hippo signaling pathway_Homo sapiens_hsa043900.60566097
95Hedgehog signaling pathway_Homo sapiens_hsa043400.59636581
96Lysine degradation_Homo sapiens_hsa003100.57939566
97Type I diabetes mellitus_Homo sapiens_hsa049400.57886597
98MAPK signaling pathway_Homo sapiens_hsa040100.56686996
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56341669
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55231286
101Peroxisome_Homo sapiens_hsa041460.54577891
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54100754
103Ovarian steroidogenesis_Homo sapiens_hsa049130.52280630
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52006966
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51674062
106Insulin signaling pathway_Homo sapiens_hsa049100.49702275
107Ras signaling pathway_Homo sapiens_hsa040140.49478931
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49431016
109Bile secretion_Homo sapiens_hsa049760.49356006
110Endometrial cancer_Homo sapiens_hsa052130.48591179
111Dilated cardiomyopathy_Homo sapiens_hsa054140.48440065
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48391301
113Butanoate metabolism_Homo sapiens_hsa006500.47921775
114Renal cell carcinoma_Homo sapiens_hsa052110.46684180
115Nitrogen metabolism_Homo sapiens_hsa009100.46200650
116Alcoholism_Homo sapiens_hsa050340.45956052
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45641933
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45538666
119Retinol metabolism_Homo sapiens_hsa008300.44419359
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44368949
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43528482
122TGF-beta signaling pathway_Homo sapiens_hsa043500.42389594
123Fatty acid degradation_Homo sapiens_hsa000710.42255246
124Histidine metabolism_Homo sapiens_hsa003400.41788230
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41187054
126Wnt signaling pathway_Homo sapiens_hsa043100.40963027
127Mineral absorption_Homo sapiens_hsa049780.40150040
128Prion diseases_Homo sapiens_hsa050200.40075993
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.36784677
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36218986
131Prolactin signaling pathway_Homo sapiens_hsa049170.35733883
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35499838
133Rap1 signaling pathway_Homo sapiens_hsa040150.32979831
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.31284782
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31075710
136mRNA surveillance pathway_Homo sapiens_hsa030150.31044135
137FoxO signaling pathway_Homo sapiens_hsa040680.30522564
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30112588
139Endocytosis_Homo sapiens_hsa041440.26881093
140AMPK signaling pathway_Homo sapiens_hsa041520.23614663

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