USP36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.78722155
2nuclear pore organization (GO:0006999)4.73593289
3regulation of translational fidelity (GO:0006450)4.03207265
4pre-miRNA processing (GO:0031054)3.91420468
5negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.91391363
6mannose metabolic process (GO:0006013)3.83896855
7pore complex assembly (GO:0046931)3.80585419
8IMP biosynthetic process (GO:0006188)3.80081928
9regulation of interleukin-12 biosynthetic process (GO:0045075)3.78354836
10negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.65216269
11histone H4-K12 acetylation (GO:0043983)3.62519739
12dosage compensation (GO:0007549)3.62300242
13embryonic process involved in female pregnancy (GO:0060136)3.59307331
14positive thymic T cell selection (GO:0045059)3.57287877
15regulation of nucleobase-containing compound transport (GO:0032239)3.55403856
16response to muramyl dipeptide (GO:0032495)3.51409939
17DNA topological change (GO:0006265)3.49519098
18tolerance induction (GO:0002507)3.48961710
19regulation of NFAT protein import into nucleus (GO:0051532)3.38921700
20regulation of gamma-delta T cell differentiation (GO:0045586)3.35727955
21mitotic nuclear envelope disassembly (GO:0007077)3.35473452
22negative regulation of histone methylation (GO:0031061)3.35098862
23folic acid-containing compound biosynthetic process (GO:0009396)3.35067032
24negative regulation of mRNA processing (GO:0050686)3.33775937
25positive regulation of gamma-delta T cell activation (GO:0046645)3.32895280
26interferon-gamma production (GO:0032609)3.25725806
27histone H3-K36 demethylation (GO:0070544)3.23756035
28NIK/NF-kappaB signaling (GO:0038061)3.17847509
29nuclear envelope disassembly (GO:0051081)3.13589082
30membrane disassembly (GO:0030397)3.13589082
31alternative mRNA splicing, via spliceosome (GO:0000380)3.12938073
32intracellular estrogen receptor signaling pathway (GO:0030520)3.11320532
33regulation of gamma-delta T cell activation (GO:0046643)3.10417149
34ribosome biogenesis (GO:0042254)3.10015210
35histone H3-K4 methylation (GO:0051568)3.07902307
36IMP metabolic process (GO:0046040)3.07483173
37response to laminar fluid shear stress (GO:0034616)3.07061591
38positive T cell selection (GO:0043368)3.03760637
39positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.03023350
40negative regulation of RNA splicing (GO:0033119)3.00981554
41protein localization to kinetochore (GO:0034501)2.97572078
42regulation of histone H3-K27 methylation (GO:0061085)2.97510471
43histone H2A monoubiquitination (GO:0035518)2.96545198
44DNA unwinding involved in DNA replication (GO:0006268)2.93130710
45mitotic sister chromatid cohesion (GO:0007064)2.92062331
46mitotic chromosome condensation (GO:0007076)2.91065192
47DNA duplex unwinding (GO:0032508)2.90691119
48mRNA stabilization (GO:0048255)2.90237349
49RNA stabilization (GO:0043489)2.90237349
50DNA geometric change (GO:0032392)2.87545303
51nucleobase biosynthetic process (GO:0046112)2.87278064
52spliceosomal tri-snRNP complex assembly (GO:0000244)2.85549558
53regulation of posttranscriptional gene silencing (GO:0060147)2.85223859
54regulation of gene silencing by miRNA (GO:0060964)2.85223859
55regulation of gene silencing by RNA (GO:0060966)2.85223859
56negative regulation of mRNA metabolic process (GO:1903312)2.85218111
57thymic T cell selection (GO:0045061)2.83578527
58positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.80228813
59regulation of chromatin binding (GO:0035561)2.77968512
60adherens junction assembly (GO:0034333)2.77887579
61histone H3-K4 trimethylation (GO:0080182)2.77598834
62positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.76144126
63trophoblast giant cell differentiation (GO:0060707)2.72960895
64focal adhesion assembly (GO:0048041)2.72349684
65cell-substrate adherens junction assembly (GO:0007045)2.72349684
66regulation of nuclear cell cycle DNA replication (GO:0033262)2.69790941
67histone lysine demethylation (GO:0070076)2.68531076
68histone demethylation (GO:0016577)2.68307204
69regulation of type I interferon-mediated signaling pathway (GO:0060338)2.68101665
70histone H3-K9 demethylation (GO:0033169)2.67832822
71snRNA metabolic process (GO:0016073)2.66651214
72inner cell mass cell proliferation (GO:0001833)2.66526448
73positive regulation of RNA splicing (GO:0033120)2.66421739
74negative T cell selection (GO:0043383)2.65732805
75positive regulation of histone deacetylation (GO:0031065)2.64849121
76regulation of RNA export from nucleus (GO:0046831)2.64616385
77apoptotic process involved in morphogenesis (GO:0060561)2.63653818
78negative thymic T cell selection (GO:0045060)2.63403265
79cellular protein complex localization (GO:0034629)2.63204050
80trophectodermal cell differentiation (GO:0001829)2.62453243
81mRNA splice site selection (GO:0006376)2.62360567
82mRNA transport (GO:0051028)2.61806090
83glucocorticoid receptor signaling pathway (GO:0042921)2.61620315
84nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.58710759
85negative regulation of translation, ncRNA-mediated (GO:0040033)2.58508176
86regulation of translation, ncRNA-mediated (GO:0045974)2.58508176
87negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.58508176
88histone deubiquitination (GO:0016578)2.58276089
89mRNA export from nucleus (GO:0006406)2.55390952
90nuclear envelope organization (GO:0006998)2.55178315
91modulation by virus of host process (GO:0019054)2.54322483
923-UTR-mediated mRNA stabilization (GO:0070935)2.53955692
93negative regulation of erythrocyte differentiation (GO:0045647)2.53564735
94snRNA processing (GO:0016180)2.53443230
95RNA export from nucleus (GO:0006405)2.53205754
96histone H4 acetylation (GO:0043967)2.52215876
97protein export from nucleus (GO:0006611)2.51571479
98regulation of mammary gland epithelial cell proliferation (GO:0033599)2.51201302
99activation of Rac GTPase activity (GO:0032863)2.51164519
100histone H3 acetylation (GO:0043966)2.50496708
101histone H4-K5 acetylation (GO:0043981)2.49397146
102histone H4-K8 acetylation (GO:0043982)2.49397146
103N-terminal protein amino acid acetylation (GO:0006474)2.49261322
104positive regulation of keratinocyte differentiation (GO:0045618)2.48711058
105T cell selection (GO:0045058)2.46110369
106cellular response to epidermal growth factor stimulus (GO:0071364)2.45732100
107regulation of interleukin-2 biosynthetic process (GO:0045076)2.44140747
108histone acetylation (GO:0016573)2.42969614
109CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.42350018
110histone lysine methylation (GO:0034968)2.41918478
111regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.41285254
112COPI coating of Golgi vesicle (GO:0048205)2.41077063
113Golgi transport vesicle coating (GO:0048200)2.41077063
114positive regulation of gene expression, epigenetic (GO:0045815)2.40875466
115positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.39973988
116RNA transport (GO:0050658)2.39638477
117establishment of RNA localization (GO:0051236)2.39638477
118nucleic acid transport (GO:0050657)2.39638477
119regulation of mRNA catabolic process (GO:0061013)2.39329952
120histone methylation (GO:0016571)2.39218837
121regulation of cholesterol homeostasis (GO:2000188)2.39111228
122negative regulation of histone modification (GO:0031057)2.38820229
123histone H2A acetylation (GO:0043968)2.38644101
124protein demethylation (GO:0006482)2.38407110
125protein dealkylation (GO:0008214)2.38407110
126activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38279622
127histone mRNA catabolic process (GO:0071044)2.38122158
128RNA splicing, via transesterification reactions (GO:0000375)2.37398165
129stress granule assembly (GO:0034063)2.37360569
130regulation of gene silencing (GO:0060968)2.37055406
131mRNA splicing, via spliceosome (GO:0000398)2.36280746
132RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.36280746
133maturation of SSU-rRNA (GO:0030490)2.35986247
134positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.35528253
135nuclear export (GO:0051168)2.34647739
136positive regulation of protein deacetylation (GO:0090312)2.34000536
137modulation by symbiont of host cellular process (GO:0044068)2.33614682
138regulation of necroptotic process (GO:0060544)2.33569184
139regulation of histone methylation (GO:0031060)2.33545181
140cellular response to interleukin-4 (GO:0071353)2.33010735
141somatic hypermutation of immunoglobulin genes (GO:0016446)2.32514643
142somatic diversification of immune receptors via somatic mutation (GO:0002566)2.32514643
143corticosteroid receptor signaling pathway (GO:0031958)2.32376112
144DNA conformation change (GO:0071103)2.32331245
145internal peptidyl-lysine acetylation (GO:0018393)2.32290130
146histone H4-K16 acetylation (GO:0043984)2.32155749
147positive regulation of nuclease activity (GO:0032075)2.32107723
148entrainment of circadian clock by photoperiod (GO:0043153)2.31969382
149pinocytosis (GO:0006907)2.31033128
150positive regulation of interleukin-2 production (GO:0032743)2.29375252
151poly(A)+ mRNA export from nucleus (GO:0016973)2.25343051
152response to interleukin-15 (GO:0070672)2.24563683
153regulation of DNA damage checkpoint (GO:2000001)2.23783327
154endoplasmic reticulum unfolded protein response (GO:0030968)2.22577695
155intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.21385679
156germinal center formation (GO:0002467)2.20520761
157histone H3-K9 modification (GO:0061647)2.20403974
158positive regulation of mRNA catabolic process (GO:0061014)2.20194320
159regulation of histone H3-K4 methylation (GO:0051569)2.19924960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.27708431
2MYC_22102868_ChIP-Seq_BL_Human4.29044524
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.93782799
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.19446218
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.07920399
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.06433204
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.01157242
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.86951602
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.86323776
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65631119
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53975096
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51510065
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32245744
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21972595
15VDR_21846776_ChIP-Seq_THP-1_Human2.19704835
16TCF7_22412390_ChIP-Seq_EML_Mouse2.13384088
17DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.04466402
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99576030
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.99532509
20CIITA_25753668_ChIP-Seq_RAJI_Human1.96213408
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85766959
22E2F1_21310950_ChIP-Seq_MCF-7_Human1.79454949
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78526818
24LXR_22292898_ChIP-Seq_THP-1_Human1.78300064
25KDM2B_26808549_Chip-Seq_DND41_Human1.77364242
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.72956812
27MAF_26560356_Chip-Seq_TH1_Human1.66570848
28* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.63442119
29* MYB_26560356_Chip-Seq_TH1_Human1.63422185
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62333326
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59552883
32UTX_26944678_Chip-Seq_JUKART_Human1.57590792
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57292268
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57238972
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56687161
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49404170
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48621266
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48621266
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48621266
40KDM5A_27292631_Chip-Seq_BREAST_Human1.47214488
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45771765
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45013262
43XRN2_22483619_ChIP-Seq_HELA_Human1.44680852
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43377279
45SCL_19346495_ChIP-Seq_HPC-7_Human1.42226835
46ZNF263_19887448_ChIP-Seq_K562_Human1.41614585
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41059915
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40769482
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.40280880
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39229991
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38580968
52* NCOR1_26117541_ChIP-Seq_K562_Human1.37332622
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36871826
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36467149
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34797210
56MYB_26560356_Chip-Seq_TH2_Human1.33359657
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32982475
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32938782
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30972799
60* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29758561
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27692341
62MAF_26560356_Chip-Seq_TH2_Human1.27514044
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27347841
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26347858
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25944610
66SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23411189
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21689106
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21607761
69RUNX_20019798_ChIP-Seq_JUKART_Human1.20497857
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19380759
71* KDM2B_26808549_Chip-Seq_JURKAT_Human1.19092474
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19037341
73CLOCK_20551151_ChIP-Seq_293T_Human1.18657310
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17971575
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17201428
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16587325
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.16571867
78* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16386057
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.15319803
80* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14490987
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13956712
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13730070
83* FOXP3_21729870_ChIP-Seq_TREG_Human1.13594219
84TTF2_22483619_ChIP-Seq_HELA_Human1.13249049
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12957690
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10899223
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10754368
88BP1_19119308_ChIP-ChIP_Hs578T_Human1.10070620
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09818602
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09746759
91PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09734172
92RUNX1_22412390_ChIP-Seq_EML_Mouse1.09469720
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09465829
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09054339
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08449555
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08388124
97CREB1_26743006_Chip-Seq_LNCaP_Human1.07216260
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05967184
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05476082
100SA1_27219007_Chip-Seq_ERYTHROID_Human1.05017992
101ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04885818
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01551300
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01304118
104TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01251070
105ATF3_27146783_Chip-Seq_COLON_Human1.00826768
106PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00688664
107VDR_24763502_ChIP-Seq_THP-1_Human1.00249368
108ESR2_21235772_ChIP-Seq_MCF-7_Human1.00155458
109* P68_20966046_ChIP-Seq_HELA_Human0.99764169
110TET1_21451524_ChIP-Seq_MESCs_Mouse0.99649083
111RACK7_27058665_Chip-Seq_MCF-7_Human0.98646371
112TFEB_21752829_ChIP-Seq_HELA_Human0.97208265
113* VDR_23849224_ChIP-Seq_CD4+_Human0.96362797
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95168530
115KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94615098
116* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94048026
117MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93649102
118ETS1_20019798_ChIP-Seq_JURKAT_Human0.90945109
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88929390
120HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.88199537
121KDM2B_26808549_Chip-Seq_K562_Human0.88122366
122ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86978169
123GABP_19822575_ChIP-Seq_HepG2_Human0.86197855
124CHD1_26751641_Chip-Seq_LNCaP_Human0.86009202
125P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85865379
126AR_21909140_ChIP-Seq_LNCAP_Human0.85107616
127FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85000867
128STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84518819
129FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.83007954
130NANOG_21062744_ChIP-ChIP_HESCs_Human0.82943993
131RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82922531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.64344928
2MP0002396_abnormal_hematopoietic_system2.88695833
3MP0003111_abnormal_nucleus_morphology2.86427205
4MP0003763_abnormal_thymus_physiology2.83836168
5MP0005451_abnormal_body_composition2.83112739
6MP0010094_abnormal_chromosome_stability2.67954507
7MP0003693_abnormal_embryo_hatching2.48642859
8MP0003077_abnormal_cell_cycle2.32371820
9MP0005076_abnormal_cell_differentiation2.26297595
10MP0010352_gastrointestinal_tract_polyps2.23701120
11MP0008007_abnormal_cellular_replicative2.22618138
12MP0008961_abnormal_basal_metabolism2.21796234
13MP0004957_abnormal_blastocyst_morpholog2.14700094
14MP0002009_preneoplasia2.12439056
15MP0001873_stomach_inflammation2.06835824
16MP0008058_abnormal_DNA_repair1.88139735
17MP0001348_abnormal_lacrimal_gland1.87799238
18MP0004947_skin_inflammation1.83620928
19MP0010030_abnormal_orbit_morphology1.82985972
20MP0009840_abnormal_foam_cell1.82009459
21MP0004808_abnormal_hematopoietic_stem1.77582891
22MP0003890_abnormal_embryonic-extraembry1.77370899
23MP0003172_abnormal_lysosome_physiology1.74195193
24MP0000703_abnormal_thymus_morphology1.74111968
25MP0000350_abnormal_cell_proliferation1.73282587
26MP0002166_altered_tumor_susceptibility1.72084928
27MP0008260_abnormal_autophagy1.69199029
28MP0005075_abnormal_melanosome_morpholog1.66894725
29MP0005058_abnormal_lysosome_morphology1.66094201
30MP0001730_embryonic_growth_arrest1.63900092
31MP0003786_premature_aging1.62007617
32MP0004510_myositis1.61861867
33MP0001672_abnormal_embryogenesis/_devel1.60902406
34MP0005380_embryogenesis_phenotype1.60902406
35MP0004233_abnormal_muscle_weight1.60740640
36MP0003984_embryonic_growth_retardation1.58569380
37MP0002088_abnormal_embryonic_growth/wei1.58212053
38MP0003123_paternal_imprinting1.54955887
39MP0004197_abnormal_fetal_growth/weight/1.52820770
40MP0002398_abnormal_bone_marrow1.52439468
41MP0002877_abnormal_melanocyte_morpholog1.51007236
42MP0003121_genomic_imprinting1.50909691
43MP0003453_abnormal_keratinocyte_physiol1.47140694
44MP0005000_abnormal_immune_tolerance1.46699920
45MP0006292_abnormal_olfactory_placode1.45352501
46MP0002084_abnormal_developmental_patter1.44460537
47MP0003091_abnormal_cell_migration1.44368066
48MP0004185_abnormal_adipocyte_glucose1.44251824
49MP0002086_abnormal_extraembryonic_tissu1.39598142
50MP0002085_abnormal_embryonic_tissue1.38866911
51MP0009333_abnormal_splenocyte_physiolog1.38397836
52MP0000858_altered_metastatic_potential1.38316026
53MP0001800_abnormal_humoral_immune1.37056117
54MP0001853_heart_inflammation1.35032762
55MP0000490_abnormal_crypts_of1.34143419
56MP0009278_abnormal_bone_marrow1.33437879
57MP0008995_early_reproductive_senescence1.31954112
58MP0002006_tumorigenesis1.30473668
59MP0000003_abnormal_adipose_tissue1.28315913
60MP0002722_abnormal_immune_system1.26868940
61MP0002405_respiratory_system_inflammati1.26671299
62MP0005387_immune_system_phenotype1.26297039
63MP0001790_abnormal_immune_system1.26297039
64MP0008932_abnormal_embryonic_tissue1.25814539
65MP0005621_abnormal_cell_physiology1.25472554
66MP0005670_abnormal_white_adipose1.25018635
67MP0001697_abnormal_embryo_size1.24192752
68MP0003566_abnormal_cell_adhesion1.23926323
69MP0002796_impaired_skin_barrier1.23692191
70MP0000689_abnormal_spleen_morphology1.23488247
71MP0001835_abnormal_antigen_presentation1.22944080
72MP0005023_abnormal_wound_healing1.22814265
73MP0001851_eye_inflammation1.21324509
74MP0002998_abnormal_bone_remodeling1.17800539
75MP0002060_abnormal_skin_morphology1.17590080
76MP0005375_adipose_tissue_phenotype1.16185014
77MP0005409_darkened_coat_color1.16045915
78MP0000685_abnormal_immune_system1.15454946
79MP0002080_prenatal_lethality1.14991128
80MP0010155_abnormal_intestine_physiology1.14972363
81MP0005666_abnormal_adipose_tissue1.09994281
82MP0002933_joint_inflammation1.09379060
83MP0000733_abnormal_muscle_development1.09294207
84MP0003119_abnormal_digestive_system1.07902974
85MP0003567_abnormal_fetal_cardiomyocyte1.06848960
86MP0000716_abnormal_immune_system1.04665769
87MP0005025_abnormal_response_to1.04463140
88MP0005671_abnormal_response_to1.03726515
89MP0000678_abnormal_parathyroid_gland1.03635463
90MP0003303_peritoneal_inflammation1.02814337
91MP0000537_abnormal_urethra_morphology1.02717627
92MP0002254_reproductive_system_inflammat1.02214910
93MP0002419_abnormal_innate_immunity1.02137092
94MP0001216_abnormal_epidermal_layer1.01270990
95MP0002429_abnormal_blood_cell1.00598045
96MP0000428_abnormal_craniofacial_morphol1.00501756
97MP0002019_abnormal_tumor_incidence0.99799290
98MP0002925_abnormal_cardiovascular_devel0.99655361
99MP0008877_abnormal_DNA_methylation0.98976455
100MP0002970_abnormal_white_adipose0.98027131
101MP0003950_abnormal_plasma_membrane0.97132315
102MP0003787_abnormal_imprinting0.96782256
103MP0009115_abnormal_fat_cell0.95829258
104MP0002452_abnormal_antigen_presenting0.95520571
105MP0001545_abnormal_hematopoietic_system0.95110914
106MP0005397_hematopoietic_system_phenotyp0.95110914
107MP0001849_ear_inflammation0.94945043
108MP0009672_abnormal_birth_weight0.94859573
109MP0005501_abnormal_skin_physiology0.94600155
110MP0003866_abnormal_defecation0.94489422
111MP0002420_abnormal_adaptive_immunity0.94013019
112MP0003828_pulmonary_edema0.92892665
113MP0000432_abnormal_head_morphology0.92828259
114MP0000313_abnormal_cell_death0.92692051
115MP0004381_abnormal_hair_follicle0.92349289
116MP0003705_abnormal_hypodermis_morpholog0.92294177
117MP0002723_abnormal_immune_serum0.92165911
118MP0003943_abnormal_hepatobiliary_system0.91561757
119MP0003300_gastrointestinal_ulcer0.91413721
120MP0002089_abnormal_postnatal_growth/wei0.89928123
121MP0000566_synostosis0.89440136
122MP0001819_abnormal_immune_cell0.89105006
123MP0009931_abnormal_skin_appearance0.89028178
124MP0003935_abnormal_craniofacial_develop0.87998330
125MP0005310_abnormal_salivary_gland0.85308336
126MP0005384_cellular_phenotype0.84269460
127MP0001293_anophthalmia0.84147908
128MP0009703_decreased_birth_body0.82551926
129MP0005174_abnormal_tail_pigmentation0.82388685
130MP0004264_abnormal_extraembryonic_tissu0.81992116
131MP0002075_abnormal_coat/hair_pigmentati0.80848024
132MP0003115_abnormal_respiratory_system0.78986953
133MP0002111_abnormal_tail_morphology0.78387931
134MP0010307_abnormal_tumor_latency0.76039002
135MP0002697_abnormal_eye_size0.75966182
136MP0003315_abnormal_perineum_morphology0.75295733
137MP0002116_abnormal_craniofacial_bone0.75000283
138MP0003436_decreased_susceptibility_to0.74832225
139MP0002249_abnormal_larynx_morphology0.74157067
140MP0000383_abnormal_hair_follicle0.74054159
141MP0000569_abnormal_digit_pigmentation0.74006271

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.12151533
2Anal stenosis (HP:0002025)3.25037007
3Obstructive sleep apnea (HP:0002870)3.09303362
4Ectopic kidney (HP:0000086)3.06422151
5Intestinal fistula (HP:0100819)2.85984011
6Hyperacusis (HP:0010780)2.84347186
7Ependymoma (HP:0002888)2.67195125
8Long eyelashes (HP:0000527)2.64492832
9Urethral obstruction (HP:0000796)2.59735239
10Disproportionate tall stature (HP:0001519)2.50399126
11Fatigue (HP:0012378)2.47272635
12Cerebral aneurysm (HP:0004944)2.45076839
13Dysmetric saccades (HP:0000641)2.43781198
14Deep palmar crease (HP:0006191)2.41791102
15Abnormal number of incisors (HP:0011064)2.32607414
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31091113
17Progressive muscle weakness (HP:0003323)2.29499171
18Rib fusion (HP:0000902)2.28870240
19Increased density of long bones (HP:0006392)2.28418630
20Abnormality of the labia minora (HP:0012880)2.25358190
21Lip pit (HP:0100267)2.24257923
22Increased nuchal translucency (HP:0010880)2.24054853
23Pustule (HP:0200039)2.23738383
24Premature skin wrinkling (HP:0100678)2.23674036
25Slow saccadic eye movements (HP:0000514)2.23194408
26Chromsome breakage (HP:0040012)2.20006755
27Deviation of the thumb (HP:0009603)2.18449098
28Sparse lateral eyebrow (HP:0005338)2.15485179
29Proximal placement of thumb (HP:0009623)2.12810193
30Supernumerary ribs (HP:0005815)2.10750671
31T lymphocytopenia (HP:0005403)2.10615125
32Segmental peripheral demyelination/remyelination (HP:0003481)2.10439487
33Medulloblastoma (HP:0002885)2.07949921
34Broad palm (HP:0001169)2.07138594
35Abnormality of the thoracic spine (HP:0100711)2.05954334
36Colitis (HP:0002583)2.03432979
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.02555313
38Intestinal atresia (HP:0011100)2.01240466
39Basal cell carcinoma (HP:0002671)2.00612462
40Supernumerary bones of the axial skeleton (HP:0009144)2.00221785
41Abnormality of the columella (HP:0009929)1.99103034
42Volvulus (HP:0002580)1.97498601
43Trigonocephaly (HP:0000243)1.96705777
44Abnormality of T cell number (HP:0011839)1.96112055
45Trismus (HP:0000211)1.95397597
46Depressed nasal tip (HP:0000437)1.94231429
47Asymmetry of the thorax (HP:0001555)1.92548270
48Protrusio acetabuli (HP:0003179)1.92191032
49Flat acetabular roof (HP:0003180)1.91867693
50Achilles tendon contracture (HP:0001771)1.91790027
51Seborrheic dermatitis (HP:0001051)1.90635891
52Absent radius (HP:0003974)1.90003878
53Ulnar bowing (HP:0003031)1.89213480
54Broad thumb (HP:0011304)1.89184475
55Increased connective tissue (HP:0009025)1.88897516
56Oligodontia (HP:0000677)1.88874668
57Rectal fistula (HP:0100590)1.88663026
58Rectovaginal fistula (HP:0000143)1.88663026
59Increased IgE level (HP:0003212)1.88168254
60Limited elbow extension (HP:0001377)1.87854025
61Gastrointestinal inflammation (HP:0004386)1.87567583
62Short 4th metacarpal (HP:0010044)1.86464388
63Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.86464388
64Persistence of primary teeth (HP:0006335)1.85831786
65Myelodysplasia (HP:0002863)1.84681633
66Overlapping toe (HP:0001845)1.84587316
67Prominent nose (HP:0000448)1.84533091
68Abnormality of the humeroradial joint (HP:0100744)1.84495895
69Progressive external ophthalmoplegia (HP:0000590)1.83679985
70Prominent metopic ridge (HP:0005487)1.83252008
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.82911010
72Lymphoma (HP:0002665)1.80266587
73Renal duplication (HP:0000075)1.79579536
74Duplicated collecting system (HP:0000081)1.77379991
75Abnormality of oral frenula (HP:0000190)1.77112444
76Abnormality of the metopic suture (HP:0005556)1.76691329
77Distal lower limb amyotrophy (HP:0008944)1.76529385
78Panhypogammaglobulinemia (HP:0003139)1.76398672
79Flat cornea (HP:0007720)1.76387365
80Acute myeloid leukemia (HP:0004808)1.76235840
81Subacute progressive viral hepatitis (HP:0006572)1.76154402
82Aneurysm (HP:0002617)1.75698132
83Abnormality of the nasal septum (HP:0000419)1.73703301
84Thin bony cortex (HP:0002753)1.73468767
85Deep philtrum (HP:0002002)1.73275695
86Microvesicular hepatic steatosis (HP:0001414)1.72948718
87Abnormality of T cells (HP:0002843)1.72418585
88Vertebral compression fractures (HP:0002953)1.72237113
89Overriding aorta (HP:0002623)1.71895863
90Eczematoid dermatitis (HP:0000976)1.71578331
91Spinal cord lesions (HP:0100561)1.71473400
92Syringomyelia (HP:0003396)1.71473400
93Hypoplastic ischia (HP:0003175)1.71202920
94Astrocytoma (HP:0009592)1.71079643
95Abnormality of the astrocytes (HP:0100707)1.71079643
96Spondylolisthesis (HP:0003302)1.71069881
97J-shaped sella turcica (HP:0002680)1.70283031
98Absent forearm bone (HP:0003953)1.69526910
99Aplasia involving forearm bones (HP:0009822)1.69526910
100Upper limb amyotrophy (HP:0009129)1.68401823
101Distal upper limb amyotrophy (HP:0007149)1.68401823
102Short thumb (HP:0009778)1.68291510
103Chin dimple (HP:0010751)1.68046447
104Skin tags (HP:0010609)1.68001392
105Self-mutilation (HP:0000742)1.67900141
106Autoimmune hemolytic anemia (HP:0001890)1.67654524
107Rough bone trabeculation (HP:0100670)1.67432764
108Abnormality of the distal phalanx of the thumb (HP:0009617)1.67034351
109Dislocated radial head (HP:0003083)1.66087451
110Mitral regurgitation (HP:0001653)1.65581123
111Premature graying of hair (HP:0002216)1.65066540
112Abnormality of the Achilles tendon (HP:0005109)1.65063282
113Ragged-red muscle fibers (HP:0003200)1.64171790
114Thoracic kyphosis (HP:0002942)1.63203959
115Viral hepatitis (HP:0006562)1.63165384
116Natal tooth (HP:0000695)1.62817117
117Patellar dislocation (HP:0002999)1.62684177
118Vertebral arch anomaly (HP:0008438)1.62361211
119Squamous cell carcinoma (HP:0002860)1.61798766
120Neoplasm of striated muscle (HP:0009728)1.61049827
121Recurrent viral infections (HP:0004429)1.60768674
122Absent thumb (HP:0009777)1.60165760
123Supernumerary nipples (HP:0002558)1.59729092
124Mitral valve prolapse (HP:0001634)1.59548337
125Vertebral fusion (HP:0002948)1.59431729
126Cellulitis (HP:0100658)1.58838115
127Abnormality of the radial head (HP:0003995)1.58781430
128Neoplasm of the oral cavity (HP:0100649)1.58591924
129IgA deficiency (HP:0002720)1.57026844
130Advanced eruption of teeth (HP:0006288)1.56628663
131Ankyloglossia (HP:0010296)1.56627557
132Entropion (HP:0000621)1.56352705
133Shallow orbits (HP:0000586)1.56179678
134Pointed chin (HP:0000307)1.55912225
135Thrombocytosis (HP:0001894)1.55742299
136Recurrent fungal infections (HP:0002841)1.55597264
137Short humerus (HP:0005792)1.55347802
138Inflammation of the large intestine (HP:0002037)1.54573922
139Interstitial pulmonary disease (HP:0006530)1.54507838
140Abnormality of the incisor (HP:0000676)1.54333700
141Stomatitis (HP:0010280)1.54276781
142Elbow flexion contracture (HP:0002987)1.53482090
143Centrally nucleated skeletal muscle fibers (HP:0003687)1.53123269
144Cervical subluxation (HP:0003308)1.52929795
145Facial hemangioma (HP:0000329)1.52415885
146Long clavicles (HP:0000890)1.51887522
147Selective tooth agenesis (HP:0001592)1.51745737
148Gastrointestinal stroma tumor (HP:0100723)1.51124665
149Heterotopia (HP:0002282)1.51041248
150Severe combined immunodeficiency (HP:0004430)1.50846695
151Biconcave vertebral bodies (HP:0004586)1.50769822
152Macroorchidism (HP:0000053)1.50101162
153Spina bifida occulta (HP:0003298)1.49930819
154Emphysema (HP:0002097)1.48550824
155Ureteral duplication (HP:0000073)1.48358457
156Preauricular skin tag (HP:0000384)1.48268803
157Stridor (HP:0010307)1.47627916
158Broad phalanges of the hand (HP:0009768)1.47601218
159Broad face (HP:0000283)1.47569077
160Long palpebral fissure (HP:0000637)1.47547268
161Abnormality of the renal collecting system (HP:0004742)1.47239868
162Sparse scalp hair (HP:0002209)1.47088204
163Spinal muscular atrophy (HP:0007269)1.46819354
164Glioma (HP:0009733)1.46562611
165Aplasia/hypoplasia of the humerus (HP:0006507)1.46367741
166Narrow palate (HP:0000189)1.46302366
167Somatic mutation (HP:0001428)1.45381193
168Short phalanx of the thumb (HP:0009660)1.44974964
169Acute lymphatic leukemia (HP:0006721)1.44707736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.07977488
2BRD43.63107586
3MAP4K13.45859406
4SMG13.10396610
5EEF2K2.98910464
6TXK2.38986205
7TSSK62.12127141
8MAP2K32.06815432
9MAP3K101.96083961
10RIPK11.84775471
11MAP3K131.78011987
12MKNK21.76980247
13ALK1.76842603
14MAP3K31.74005549
15STK101.67005810
16PASK1.66157074
17CDC71.48576577
18JAK31.47931282
19MKNK11.42416179
20CDK71.37712035
21CHUK1.31440071
22MAP3K141.31421608
23MTOR1.31101254
24CHEK11.30274525
25ICK1.29453164
26CDK41.24142460
27TAOK11.22151239
28NME21.22068199
29RPS6KB21.20633827
30CLK11.19461892
31MAPK111.16752417
32ATR1.14078727
33RPS6KA41.11286357
34PIM11.10467161
35MARK21.10408787
36ITK1.07546594
37IKBKB1.07185570
38TTK1.07147694
39ZAP701.05981791
40MAP3K111.03791123
41ERN11.03181576
42TGFBR11.02934313
43SIK31.01880438
44MST1R1.01106217
45PDGFRA1.00882691
46HIPK21.00766369
47PRPF4B1.00045697
48TYK20.98896567
49EPHA20.95982001
50SIK20.94252750
51PAK20.92793091
52CDK80.91894124
53BMX0.91636836
54MELK0.90605011
55JAK10.87201452
56CDK20.86318516
57PDGFRB0.86243750
58TBK10.85600233
59BTK0.81724135
60SRPK10.81678641
61ATM0.80999421
62TTN0.80387860
63MAP3K70.80040379
64BUB10.80035137
65CDC42BPA0.77349777
66CSK0.77089941
67ZAK0.76633990
68CDK60.75797394
69FGFR40.74684011
70TRIB30.73781995
71CAMK1D0.73287270
72MAP3K10.72642437
73CAMK1G0.71404682
74NEK20.70748416
75TRPM70.70322310
76NLK0.70204816
77GRK60.69832125
78TAOK20.69243193
79HCK0.69210530
80MARK30.68030925
81MAPK70.67710899
82PIM20.67095342
83PRKD30.65481284
84UHMK10.64964902
85PRKD20.64886074
86PKN20.64576152
87AKT30.62588198
88CDK90.61209486
89CSNK1D0.61053366
90CHEK20.60463706
91MAPK10.59909061
92TAOK30.59789374
93MAPK140.59417518
94IRAK30.59383377
95LCK0.58261618
96AKT20.57273942
97MAP3K80.57249158
98PAK40.56809744
99TEC0.56741278
100AURKB0.56294828
101CAMKK10.56044904
102FGFR30.55882486
103IKBKE0.55381455
104PDPK10.55339940
105FES0.54710427
106MAP2K20.53676617
107CDK10.53249397
108PLK10.52140188
109RPS6KA10.51561574
110SIK10.51455312
111GSK3B0.51078208
112STK30.50771302
113TYRO30.50605294
114RPS6KL10.50536527
115RPS6KC10.50536527
116PDK20.50001811
117PTK20.47077366
118AKT10.46970192
119CDK30.46547084
120RPS6KA60.46011035
121KSR20.45798525
122TIE10.44897366
123MAPK120.44515415
124IRAK40.44100069
125CSF1R0.43449171
126EPHB10.43417961
127CAMK40.43414234
128MAPK100.42909937
129PDK10.42728039
130MAPKAPK20.42127267
131PTK60.41044876
132MAPK80.37950501
133WNK10.37568721
134LRRK20.35882031
135TNK20.35506924

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03461700
2One carbon pool by folate_Homo sapiens_hsa006702.70872450
3Spliceosome_Homo sapiens_hsa030402.30652356
4RNA transport_Homo sapiens_hsa030132.20729327
5DNA replication_Homo sapiens_hsa030302.16749547
6Primary immunodeficiency_Homo sapiens_hsa053402.07479863
7Base excision repair_Homo sapiens_hsa034102.06933042
8Mismatch repair_Homo sapiens_hsa034302.06193373
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05226807
10Other glycan degradation_Homo sapiens_hsa005112.03650581
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.97015593
12Homologous recombination_Homo sapiens_hsa034401.93108701
13mRNA surveillance pathway_Homo sapiens_hsa030151.86688664
14Fanconi anemia pathway_Homo sapiens_hsa034601.73307851
15RNA polymerase_Homo sapiens_hsa030201.69739498
16T cell receptor signaling pathway_Homo sapiens_hsa046601.69347314
17Transcriptional misregulation in cancer_Homo sapiens_hsa052021.58658816
18Cell cycle_Homo sapiens_hsa041101.54881395
19Acute myeloid leukemia_Homo sapiens_hsa052211.52530899
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52499784
21RNA degradation_Homo sapiens_hsa030181.44721116
22HTLV-I infection_Homo sapiens_hsa051661.44590922
23Herpes simplex infection_Homo sapiens_hsa051681.44567319
24Bladder cancer_Homo sapiens_hsa052191.44009147
25Measles_Homo sapiens_hsa051621.42000598
26Lysine degradation_Homo sapiens_hsa003101.41499720
27VEGF signaling pathway_Homo sapiens_hsa043701.40601052
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38225803
29Notch signaling pathway_Homo sapiens_hsa043301.35245138
30Chronic myeloid leukemia_Homo sapiens_hsa052201.33371264
31MicroRNAs in cancer_Homo sapiens_hsa052061.32071982
32Renal cell carcinoma_Homo sapiens_hsa052111.30990227
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26828539
34B cell receptor signaling pathway_Homo sapiens_hsa046621.20803443
35Epstein-Barr virus infection_Homo sapiens_hsa051691.14630629
36Non-homologous end-joining_Homo sapiens_hsa034501.14417366
37Small cell lung cancer_Homo sapiens_hsa052221.14175755
38Basal transcription factors_Homo sapiens_hsa030221.11765655
39Nucleotide excision repair_Homo sapiens_hsa034201.11310806
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11245395
41Basal cell carcinoma_Homo sapiens_hsa052171.09946486
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09748939
43Antigen processing and presentation_Homo sapiens_hsa046121.06591925
44Viral carcinogenesis_Homo sapiens_hsa052031.04653145
45Hepatitis C_Homo sapiens_hsa051601.04651107
46Hepatitis B_Homo sapiens_hsa051611.03401457
47p53 signaling pathway_Homo sapiens_hsa041151.02789246
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.01546274
49Glioma_Homo sapiens_hsa052141.00681084
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00065365
51Inositol phosphate metabolism_Homo sapiens_hsa005620.98276025
52Hematopoietic cell lineage_Homo sapiens_hsa046400.96053855
53Adherens junction_Homo sapiens_hsa045200.93170855
54Hippo signaling pathway_Homo sapiens_hsa043900.89909347
55Viral myocarditis_Homo sapiens_hsa054160.89620563
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89043877
57Prion diseases_Homo sapiens_hsa050200.88292510
58Choline metabolism in cancer_Homo sapiens_hsa052310.87843125
59Fructose and mannose metabolism_Homo sapiens_hsa000510.87608627
60Insulin signaling pathway_Homo sapiens_hsa049100.86953570
61Wnt signaling pathway_Homo sapiens_hsa043100.85852208
62Prostate cancer_Homo sapiens_hsa052150.85699052
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84290010
64Osteoclast differentiation_Homo sapiens_hsa043800.84225148
65Prolactin signaling pathway_Homo sapiens_hsa049170.83365933
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82964594
67Thyroid cancer_Homo sapiens_hsa052160.82900993
68Colorectal cancer_Homo sapiens_hsa052100.82621708
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.82411638
70TGF-beta signaling pathway_Homo sapiens_hsa043500.81955310
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81740725
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.81717748
73Apoptosis_Homo sapiens_hsa042100.81046132
74Influenza A_Homo sapiens_hsa051640.80987444
75Graft-versus-host disease_Homo sapiens_hsa053320.80849921
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80063377
77TNF signaling pathway_Homo sapiens_hsa046680.78639155
78Pancreatic cancer_Homo sapiens_hsa052120.77138665
79Toxoplasmosis_Homo sapiens_hsa051450.76826307
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.76313557
81mTOR signaling pathway_Homo sapiens_hsa041500.76193363
82Leishmaniasis_Homo sapiens_hsa051400.76116136
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75874278
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.75804640
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75597700
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75179404
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73260840
88MAPK signaling pathway_Homo sapiens_hsa040100.70540392
89Pathways in cancer_Homo sapiens_hsa052000.70349808
90Pyrimidine metabolism_Homo sapiens_hsa002400.70123469
91Proteoglycans in cancer_Homo sapiens_hsa052050.67618469
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.65606647
93Type I diabetes mellitus_Homo sapiens_hsa049400.65484238
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.65058537
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64844045
96N-Glycan biosynthesis_Homo sapiens_hsa005100.64086103
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63789262
98AMPK signaling pathway_Homo sapiens_hsa041520.62603184
99GnRH signaling pathway_Homo sapiens_hsa049120.61887183
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.61657703
101Endometrial cancer_Homo sapiens_hsa052130.61230735
102Estrogen signaling pathway_Homo sapiens_hsa049150.60718262
103Circadian rhythm_Homo sapiens_hsa047100.60477859
104Insulin resistance_Homo sapiens_hsa049310.59045825
105Non-small cell lung cancer_Homo sapiens_hsa052230.57488229
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56331990
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55791551
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.55574209
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55437046
110FoxO signaling pathway_Homo sapiens_hsa040680.54238296
111Hedgehog signaling pathway_Homo sapiens_hsa043400.53489692
112Pentose phosphate pathway_Homo sapiens_hsa000300.53266968
113Allograft rejection_Homo sapiens_hsa053300.52145937
114Tuberculosis_Homo sapiens_hsa051520.51754903
115Legionellosis_Homo sapiens_hsa051340.51580817
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.50566133
117ErbB signaling pathway_Homo sapiens_hsa040120.49014962
118HIF-1 signaling pathway_Homo sapiens_hsa040660.48963978
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48168626
120Chemokine signaling pathway_Homo sapiens_hsa040620.48156379
121Platelet activation_Homo sapiens_hsa046110.48017390
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47683484
123Focal adhesion_Homo sapiens_hsa045100.47146838
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46576164
125Shigellosis_Homo sapiens_hsa051310.44932866
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43956540
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43338537
128Type II diabetes mellitus_Homo sapiens_hsa049300.43143425

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