USP37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of centriole replication (GO:0046599)5.25482984
2regulation of DNA endoreduplication (GO:0032875)4.57807141
3DNA replication checkpoint (GO:0000076)4.49389340
4DNA replication initiation (GO:0006270)4.47581075
5meiotic chromosome segregation (GO:0045132)4.45835557
6mitotic metaphase plate congression (GO:0007080)4.30241520
7kinetochore organization (GO:0051383)4.26284816
8telomere maintenance via semi-conservative replication (GO:0032201)4.24982964
9DNA strand elongation involved in DNA replication (GO:0006271)4.20797118
10CENP-A containing nucleosome assembly (GO:0034080)4.15837409
11telomere maintenance via recombination (GO:0000722)4.14945687
12DNA strand elongation (GO:0022616)4.13976272
13chromatin remodeling at centromere (GO:0031055)4.12617490
14mitotic recombination (GO:0006312)4.08789807
15nuclear pore complex assembly (GO:0051292)4.01427476
16metaphase plate congression (GO:0051310)3.98448450
17nuclear pore organization (GO:0006999)3.96508958
18non-recombinational repair (GO:0000726)3.94762322
19double-strand break repair via nonhomologous end joining (GO:0006303)3.94762322
20kinetochore assembly (GO:0051382)3.90986931
21nucleobase biosynthetic process (GO:0046112)3.85035266
22attachment of spindle microtubules to kinetochore (GO:0008608)3.82229422
23regulation of nuclear cell cycle DNA replication (GO:0033262)3.81630794
24maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.80575948
25purine nucleobase biosynthetic process (GO:0009113)3.80044600
26regulation of double-strand break repair via homologous recombination (GO:0010569)3.78087134
27synapsis (GO:0007129)3.77401133
28regulation of centrosome duplication (GO:0010824)3.77176499
29protein K6-linked ubiquitination (GO:0085020)3.75472490
30regulation of histone H3-K9 methylation (GO:0051570)3.62040463
31replication fork processing (GO:0031297)3.59362343
32histone exchange (GO:0043486)3.58975820
33DNA replication-independent nucleosome organization (GO:0034724)3.58570467
34DNA replication-independent nucleosome assembly (GO:0006336)3.58570467
35protein localization to kinetochore (GO:0034501)3.56574179
36piRNA metabolic process (GO:0034587)3.55915446
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.53715442
38telomere maintenance via telomere lengthening (GO:0010833)3.53095725
39establishment of chromosome localization (GO:0051303)3.49261480
40pore complex assembly (GO:0046931)3.45729340
41nucleotide-excision repair, DNA gap filling (GO:0006297)3.43259001
42mitotic chromosome condensation (GO:0007076)3.42406420
43postreplication repair (GO:0006301)3.42302468
44mismatch repair (GO:0006298)3.41083714
45microtubule depolymerization (GO:0007019)3.40654868
46DNA synthesis involved in DNA repair (GO:0000731)3.39372314
47DNA unwinding involved in DNA replication (GO:0006268)3.37399619
48positive regulation of mitotic sister chromatid separation (GO:1901970)3.37287183
49positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.37287183
50positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.37287183
51reciprocal meiotic recombination (GO:0007131)3.35625811
52reciprocal DNA recombination (GO:0035825)3.35625811
53negative regulation of DNA-dependent DNA replication (GO:2000104)3.34154074
54telomere maintenance (GO:0000723)3.32946989
55telomere organization (GO:0032200)3.31631505
56DNA ligation (GO:0006266)3.27693984
57mitotic sister chromatid cohesion (GO:0007064)3.27055442
58negative regulation of translation, ncRNA-mediated (GO:0040033)3.25402036
59regulation of translation, ncRNA-mediated (GO:0045974)3.25402036
60negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.25402036
61regulation of sister chromatid cohesion (GO:0007063)3.25283101
62DNA methylation involved in gamete generation (GO:0043046)3.23744792
63translesion synthesis (GO:0019985)3.23189287
64pre-miRNA processing (GO:0031054)3.20532310
65IMP biosynthetic process (GO:0006188)3.20420012
66regulation of mitotic spindle checkpoint (GO:1903504)3.20115986
67regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.20115986
68positive regulation of histone H3-K4 methylation (GO:0051571)3.19565996
69DNA double-strand break processing (GO:0000729)3.19112792
70negative regulation of DNA recombination (GO:0045910)3.18460250
71sister chromatid cohesion (GO:0007062)3.15714621
72mitotic sister chromatid segregation (GO:0000070)3.15369632
73DNA geometric change (GO:0032392)3.13498811
74protein localization to chromosome, centromeric region (GO:0071459)3.09334908
75maturation of 5.8S rRNA (GO:0000460)3.08314672
76DNA duplex unwinding (GO:0032508)3.08131687
77centriole assembly (GO:0098534)3.06727798
78mitotic nuclear envelope disassembly (GO:0007077)3.05097348
79intra-S DNA damage checkpoint (GO:0031573)3.04375832
80spindle checkpoint (GO:0031577)3.01848198
81centrosome duplication (GO:0051298)3.01702761
82positive regulation of chromosome segregation (GO:0051984)3.01107426
83somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00868084
84somatic hypermutation of immunoglobulin genes (GO:0016446)3.00868084
85microtubule anchoring (GO:0034453)3.00709918
86double-strand break repair (GO:0006302)2.97682478
87transcription-coupled nucleotide-excision repair (GO:0006283)2.96687636
88regulation of double-strand break repair (GO:2000779)2.95401525
89microtubule polymerization or depolymerization (GO:0031109)2.94762984
90response to X-ray (GO:0010165)2.93810257
91chromosome segregation (GO:0007059)2.92292740
92regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92031015
93chromosome condensation (GO:0030261)2.91784608
94DNA packaging (GO:0006323)2.91395229
95centrosome organization (GO:0051297)2.90478732
96resolution of meiotic recombination intermediates (GO:0000712)2.89927971
97sister chromatid segregation (GO:0000819)2.89700002
98microtubule organizing center organization (GO:0031023)2.89574204
99chromosome organization involved in meiosis (GO:0070192)2.89573124
100neural tube formation (GO:0001841)2.89534596
101DNA conformation change (GO:0071103)2.89472877
102negative regulation of mitotic sister chromatid separation (GO:2000816)2.89431717
103negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89431717
104negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89431717
105negative regulation of sister chromatid segregation (GO:0033046)2.89431717
106spindle assembly checkpoint (GO:0071173)2.87849222
107inner cell mass cell proliferation (GO:0001833)2.87650913
108DNA-dependent DNA replication (GO:0006261)2.87501101
109negative regulation of chromosome segregation (GO:0051985)2.87372352
110regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.86196520
111regulation of mitotic sister chromatid separation (GO:0010965)2.82928655
112regulation of mitotic sister chromatid segregation (GO:0033047)2.82928655
113regulation of sister chromatid segregation (GO:0033045)2.82928655
114regulation of chromosome segregation (GO:0051983)2.82801517
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81957644
116recombinational repair (GO:0000725)2.80878541
117DNA catabolic process, exonucleolytic (GO:0000738)2.80165420
118ribosome biogenesis (GO:0042254)2.80019849
119DNA replication (GO:0006260)2.79638220
120mitotic spindle checkpoint (GO:0071174)2.79105071
121mitotic spindle assembly checkpoint (GO:0007094)2.78500081
122DNA replication-dependent nucleosome organization (GO:0034723)2.77454702
123DNA replication-dependent nucleosome assembly (GO:0006335)2.77454702
124positive regulation of DNA-dependent DNA replication (GO:2000105)2.75258667
125snRNA processing (GO:0016180)2.75244029
126regulation of centrosome cycle (GO:0046605)2.75186049
127ATP-dependent chromatin remodeling (GO:0043044)2.74588850
128double-strand break repair via homologous recombination (GO:0000724)2.74006654
129membrane disassembly (GO:0030397)2.73635540
130nuclear envelope disassembly (GO:0051081)2.73635540
131DNA topological change (GO:0006265)2.73271021
132meiotic nuclear division (GO:0007126)2.72641322
133monoubiquitinated protein deubiquitination (GO:0035520)2.72294372
134DNA strand renaturation (GO:0000733)2.71445265
135centriole replication (GO:0007099)2.71053927

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.40567631
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.71769418
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.41933476
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25461227
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.89952082
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.70658972
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.60033369
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.44962460
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35853777
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30476271
11* E2F1_21310950_ChIP-Seq_MCF-7_Human2.29335003
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.28441276
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.25605611
14GBX2_23144817_ChIP-Seq_PC3_Human2.21994469
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20545991
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19065140
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15887255
18TAF15_26573619_Chip-Seq_HEK293_Human2.14381177
19VDR_22108803_ChIP-Seq_LS180_Human2.11225550
20ZNF274_21170338_ChIP-Seq_K562_Hela2.09550117
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06165983
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05661943
23* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00053403
24E2F7_22180533_ChIP-Seq_HELA_Human11.3837746
25VDR_23849224_ChIP-Seq_CD4+_Human1.98904648
26AR_21909140_ChIP-Seq_LNCAP_Human1.98419836
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97663374
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96033257
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95481849
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92632011
31ELK1_19687146_ChIP-ChIP_HELA_Human1.90302632
32* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84608218
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84374264
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.84124453
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83881645
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83469230
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79729190
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79381567
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76045881
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.74562614
41FOXP3_21729870_ChIP-Seq_TREG_Human1.74371964
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74348479
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73577955
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.73056238
45P300_19829295_ChIP-Seq_ESCs_Human1.71721055
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71027675
47* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70881613
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60253314
49* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52715371
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50994287
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50162629
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49956960
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49434435
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48718462
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48667920
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.47342974
57STAT3_23295773_ChIP-Seq_U87_Human1.44738246
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44592197
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44346496
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.44108757
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.42221393
62SMAD4_21799915_ChIP-Seq_A2780_Human1.40767572
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40533568
64ER_23166858_ChIP-Seq_MCF-7_Human1.38962015
65CBP_20019798_ChIP-Seq_JUKART_Human1.37801630
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37801630
67TTF2_22483619_ChIP-Seq_HELA_Human1.37232697
68IRF1_19129219_ChIP-ChIP_H3396_Human1.36829310
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34069562
70* XRN2_22483619_ChIP-Seq_HELA_Human1.34052322
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32780441
72* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32702433
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32212976
74CIITA_25753668_ChIP-Seq_RAJI_Human1.31319969
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30582323
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30382069
77DCP1A_22483619_ChIP-Seq_HELA_Human1.28689538
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25613530
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25209197
80MYC_18940864_ChIP-ChIP_HL60_Human1.24870514
81TCF4_23295773_ChIP-Seq_U87_Human1.24833964
82GABP_19822575_ChIP-Seq_HepG2_Human1.23327085
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22535437
84EWS_26573619_Chip-Seq_HEK293_Human1.22299682
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21499153
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19947974
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19062076
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17649952
89EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17295136
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15594639
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14610503
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14610503
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.14220758
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.13909714
95* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13370917
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13105205
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10982590
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.10773384
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.08868427
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08645830
101FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08473879
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06826147
103* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06602932
104* NFE2_27457419_Chip-Seq_LIVER_Mouse1.06549717
105FUS_26573619_Chip-Seq_HEK293_Human1.06491950
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06380359
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06112347
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05847899
109KAP1_22055183_ChIP-Seq_ESCs_Mouse1.05349374
110* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04827491
111* E2F1_18555785_Chip-Seq_ESCs_Mouse1.04302239
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04205554
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04152193
114POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03599386
115KDM5A_27292631_Chip-Seq_BREAST_Human1.02850401
116* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01291738
117SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00985326
118AR_25329375_ChIP-Seq_VCAP_Human0.99814739
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98964578
120* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98393386
121* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96201959
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96143642
123SOX9_26525672_Chip-Seq_HEART_Mouse0.95965323
124FLI1_21867929_ChIP-Seq_TH2_Mouse0.95825477
125* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95575546
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95505449
127BCAT_22108803_ChIP-Seq_LS180_Human0.94730424
128RUNX2_22187159_ChIP-Seq_PCA_Human0.94614675
129TCF4_22108803_ChIP-Seq_LS180_Human0.93081928
130* P53_22387025_ChIP-Seq_ESCs_Mouse0.92522042
131* CRX_20693478_ChIP-Seq_RETINA_Mouse0.92268269
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92062571
133TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91719307
134* P300_18555785_Chip-Seq_ESCs_Mouse0.90625017
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90288604
136FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89825805
137HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86621972
138ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85615577
139CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82779064
140PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79066976
141GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77824068
142SPI1_23547873_ChIP-Seq_NB4_Human0.77459947
143PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.76971506
144* EZH2_27294783_Chip-Seq_NPCs_Mouse0.74979098
145POU3F2_20337985_ChIP-ChIP_501MEL_Human0.72948925
146* STAT3_18555785_Chip-Seq_ESCs_Mouse0.72078887
147NMYC_18555785_Chip-Seq_ESCs_Mouse0.70716307
148SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.70650163
149IGF1R_20145208_ChIP-Seq_DFB_Human0.68171554
150RNF2_27304074_Chip-Seq_NSC_Mouse0.67141942
151SUZ12_18555785_Chip-Seq_ESCs_Mouse0.67087931
152TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65341568
153OCT4_18555785_Chip-Seq_ESCs_Mouse0.64520197
154ZFX_18555785_Chip-Seq_ESCs_Mouse0.64200694

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.79907443
2MP0008057_abnormal_DNA_replication4.56989735
3MP0003693_abnormal_embryo_hatching4.15199910
4MP0008877_abnormal_DNA_methylation3.91991513
5MP0008058_abnormal_DNA_repair3.89293348
6MP0003111_abnormal_nucleus_morphology3.48760463
7MP0003077_abnormal_cell_cycle3.24450584
8MP0008007_abnormal_cellular_replicative2.94335291
9MP0004957_abnormal_blastocyst_morpholog2.87719666
10MP0000569_abnormal_digit_pigmentation2.79135172
11MP0006292_abnormal_olfactory_placode2.70852583
12MP0002396_abnormal_hematopoietic_system2.59043639
13MP0003786_premature_aging2.54192099
14MP0001188_hyperpigmentation2.07383173
15MP0010352_gastrointestinal_tract_polyps2.03829529
16MP0008932_abnormal_embryonic_tissue2.03014382
17MP0002210_abnormal_sex_determination1.95356606
18MP0003787_abnormal_imprinting1.83234459
19MP0003123_paternal_imprinting1.82585024
20MP0003121_genomic_imprinting1.74428466
21MP0008995_early_reproductive_senescence1.63843606
22MP0001929_abnormal_gametogenesis1.62494102
23MP0000015_abnormal_ear_pigmentation1.60590351
24MP0003718_maternal_effect1.55091178
25MP0000427_abnormal_hair_cycle1.54754191
26MP0004808_abnormal_hematopoietic_stem1.54080548
27MP0001145_abnormal_male_reproductive1.49653140
28MP0000383_abnormal_hair_follicle1.49281224
29MP0010307_abnormal_tumor_latency1.48530394
30MP0006072_abnormal_retinal_apoptosis1.47549037
31MP0003763_abnormal_thymus_physiology1.47544120
32MP0000350_abnormal_cell_proliferation1.47373536
33MP0000490_abnormal_crypts_of1.47062579
34MP0001119_abnormal_female_reproductive1.44964337
35MP0003646_muscle_fatigue1.43661560
36MP0003315_abnormal_perineum_morphology1.43372763
37MP0000653_abnormal_sex_gland1.43302220
38MP0005253_abnormal_eye_physiology1.40182005
39MP0005409_darkened_coat_color1.39653926
40MP0002160_abnormal_reproductive_system1.36546885
41MP0000566_synostosis1.35508875
42MP0009697_abnormal_copulation1.35165336
43MP0005174_abnormal_tail_pigmentation1.34963652
44MP0003950_abnormal_plasma_membrane1.32924017
45MP0002095_abnormal_skin_pigmentation1.29551865
46MP0003136_yellow_coat_color1.27862287
47MP0001986_abnormal_taste_sensitivity1.26512943
48MP0002938_white_spotting1.26489172
49MP0004197_abnormal_fetal_growth/weight/1.25241142
50MP0003941_abnormal_skin_development1.22054441
51MP0009703_decreased_birth_body1.21197771
52MP0000372_irregular_coat_pigmentation1.21193004
53MP0002876_abnormal_thyroid_physiology1.19683884
54MP0005075_abnormal_melanosome_morpholog1.17574651
55MP0003890_abnormal_embryonic-extraembry1.17513046
56MP0010678_abnormal_skin_adnexa1.17412281
57MP0005410_abnormal_fertilization1.16325456
58MP0000313_abnormal_cell_death1.14483166
59MP0003698_abnormal_male_reproductive1.13226995
60MP0005389_reproductive_system_phenotype1.12924354
61MP0002132_abnormal_respiratory_system1.12768331
62MP0009672_abnormal_birth_weight1.12012731
63MP0002163_abnormal_gland_morphology1.10416682
64MP0003943_abnormal_hepatobiliary_system1.09186579
65MP0005380_embryogenesis_phenotype1.08877659
66MP0001672_abnormal_embryogenesis/_devel1.08877659
67MP0002102_abnormal_ear_morphology1.08473600
68MP0001730_embryonic_growth_arrest1.06454000
69MP0009333_abnormal_splenocyte_physiolog1.06137487
70MP0002019_abnormal_tumor_incidence1.05714199
71MP0001293_anophthalmia1.05059443
72MP0005551_abnormal_eye_electrophysiolog1.01997569
73MP0008789_abnormal_olfactory_epithelium1.00779611
74MP0002075_abnormal_coat/hair_pigmentati0.99312992
75MP0001835_abnormal_antigen_presentation0.95288535
76MP0003937_abnormal_limbs/digits/tail_de0.94688605
77MP0005391_vision/eye_phenotype0.94475435
78MP0001186_pigmentation_phenotype0.93810198
79MP0002277_abnormal_respiratory_mucosa0.93327182
80MP0002398_abnormal_bone_marrow0.93234729
81MP0001697_abnormal_embryo_size0.92658223
82MP0005171_absent_coat_pigmentation0.92474259
83MP0002009_preneoplasia0.92262168
84MP0002085_abnormal_embryonic_tissue0.91835699
85MP0000647_abnormal_sebaceous_gland0.91596576
86MP0003984_embryonic_growth_retardation0.91586845
87MP0006276_abnormal_autonomic_nervous0.88173103
88MP0005671_abnormal_response_to0.88048559
89MP0000703_abnormal_thymus_morphology0.87053960
90MP0004782_abnormal_surfactant_physiolog0.85580725
91MP0002088_abnormal_embryonic_growth/wei0.85059408
92MP0002233_abnormal_nose_morphology0.83209851
93MP0002697_abnormal_eye_size0.82844216
94MP0003861_abnormal_nervous_system0.82799861
95MP0001545_abnormal_hematopoietic_system0.82792708
96MP0005397_hematopoietic_system_phenotyp0.82792708
97MP0001529_abnormal_vocalization0.81802551
98MP0002086_abnormal_extraembryonic_tissu0.80954213
99MP0003567_abnormal_fetal_cardiomyocyte0.80940621
100MP0000516_abnormal_urinary_system0.80829892
101MP0005367_renal/urinary_system_phenotyp0.80829892
102MP0001919_abnormal_reproductive_system0.80770533
103MP0000631_abnormal_neuroendocrine_gland0.79786593
104MP0004147_increased_porphyrin_level0.79601256
105MP0005647_abnormal_sex_gland0.79241120
106MP0003119_abnormal_digestive_system0.79209268
107MP0003935_abnormal_craniofacial_develop0.77719909
108MP0006035_abnormal_mitochondrial_morpho0.76820759
109MP0005395_other_phenotype0.76538187
110MP0003699_abnormal_female_reproductive0.76239945
111MP0002751_abnormal_autonomic_nervous0.75847688
112MP0000689_abnormal_spleen_morphology0.75761802
113MP0002080_prenatal_lethality0.75648685
114MP0000049_abnormal_middle_ear0.75256497
115MP0000778_abnormal_nervous_system0.74917364
116MP0001177_atelectasis0.74525312
117MP0002177_abnormal_outer_ear0.74518888
118MP0005646_abnormal_pituitary_gland0.73235385
119MP0005499_abnormal_olfactory_system0.72741467
120MP0005394_taste/olfaction_phenotype0.72741467
121MP0002161_abnormal_fertility/fecundity0.72709418
122MP0003755_abnormal_palate_morphology0.72682302
123MP0003221_abnormal_cardiomyocyte_apopto0.72649060
124MP0005408_hypopigmentation0.72291617
125MP0005187_abnormal_penis_morphology0.71734139
126MP0009046_muscle_twitch0.71366102
127MP0002722_abnormal_immune_system0.71118172
128MP0002638_abnormal_pupillary_reflex0.70665173
129MP0000358_abnormal_cell_content/0.70514431
130MP0005266_abnormal_metabolism0.68898247
131MP0000681_abnormal_thyroid_gland0.68853834
132MP0001286_abnormal_eye_development0.67023579
133MP0002084_abnormal_developmental_patter0.66391823
134MP0005379_endocrine/exocrine_gland_phen0.66002473
135MP0002234_abnormal_pharynx_morphology0.65918113
136MP0001984_abnormal_olfaction0.65726709
137MP0003878_abnormal_ear_physiology0.65635293
138MP0005377_hearing/vestibular/ear_phenot0.65635293
139MP0000371_diluted_coat_color0.65631962
140MP0003936_abnormal_reproductive_system0.65444673
141MP0001324_abnormal_eye_pigmentation0.65161495

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.25076957
2Chromsome breakage (HP:0040012)6.24609342
3Birth length less than 3rd percentile (HP:0003561)4.49909588
4Abnormality of chromosome stability (HP:0003220)4.14708379
5Meckel diverticulum (HP:0002245)3.96629073
6Abnormality of the preputium (HP:0100587)3.86834785
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.81853766
8Abnormality of the ileum (HP:0001549)3.80891947
9Ectopic kidney (HP:0000086)3.43630074
10Abnormal spermatogenesis (HP:0008669)3.11247962
11Nephroblastoma (Wilms tumor) (HP:0002667)3.08986438
12Small intestinal stenosis (HP:0012848)3.04570509
13Duodenal stenosis (HP:0100867)3.04570509
14Clubbing of toes (HP:0100760)3.01955331
15Impulsivity (HP:0100710)2.98145188
16Aplastic anemia (HP:0001915)2.95453043
17Patellar aplasia (HP:0006443)2.93287471
18Chronic hepatic failure (HP:0100626)2.92435527
19Embryonal renal neoplasm (HP:0011794)2.90790844
20Abnormal lung lobation (HP:0002101)2.89810918
21Breast hypoplasia (HP:0003187)2.88528473
22Myelodysplasia (HP:0002863)2.82519525
23Aplasia/Hypoplasia of the patella (HP:0006498)2.77900512
24Azoospermia (HP:0000027)2.69544243
25Type I transferrin isoform profile (HP:0003642)2.67058652
26Bone marrow hypocellularity (HP:0005528)2.65123287
27Ependymoma (HP:0002888)2.58437250
28Abnormality of the renal collecting system (HP:0004742)2.56668757
29Duplicated collecting system (HP:0000081)2.56349053
30Astrocytoma (HP:0009592)2.55138483
31Abnormality of the astrocytes (HP:0100707)2.55138483
32Glioma (HP:0009733)2.52415916
33Type 2 muscle fiber atrophy (HP:0003554)2.49732040
34Supernumerary spleens (HP:0009799)2.47869492
35Abnormality of the carotid arteries (HP:0005344)2.47436754
36Tubulointerstitial nephritis (HP:0001970)2.45535378
37Volvulus (HP:0002580)2.40009935
38Abnormality of the duodenum (HP:0002246)2.39790352
39Sloping forehead (HP:0000340)2.39299339
40Medulloblastoma (HP:0002885)2.36803361
41Abnormality of the labia minora (HP:0012880)2.35811320
42Abnormality of DNA repair (HP:0003254)2.35648902
43Abnormality of the fingertips (HP:0001211)2.32876380
44Absent thumb (HP:0009777)2.32689745
45Intestinal atresia (HP:0011100)2.31503460
46True hermaphroditism (HP:0010459)2.31156704
47Pancreatic fibrosis (HP:0100732)2.30492762
4811 pairs of ribs (HP:0000878)2.28846293
49Absent radius (HP:0003974)2.27199372
50Capillary hemangiomas (HP:0005306)2.21333868
51Neoplasm of the adrenal cortex (HP:0100641)2.19911234
52Short thumb (HP:0009778)2.19754694
53Prostate neoplasm (HP:0100787)2.13455689
54Muscle fiber atrophy (HP:0100295)2.12148814
55Triphalangeal thumb (HP:0001199)2.12002135
56Absent forearm bone (HP:0003953)2.11991789
57Aplasia involving forearm bones (HP:0009822)2.11991789
58Progressive inability to walk (HP:0002505)2.11856494
59Acute myeloid leukemia (HP:0004808)2.10860503
60Abnormal hair whorl (HP:0010721)2.08493250
61Astigmatism (HP:0000483)2.08221704
62Reticulocytopenia (HP:0001896)2.07108913
63Facial cleft (HP:0002006)2.06764743
64Premature graying of hair (HP:0002216)2.04300931
65Biliary tract neoplasm (HP:0100574)2.03895449
66Cafe-au-lait spot (HP:0000957)2.01178452
67Neoplasm of striated muscle (HP:0009728)2.00917008
68Molar tooth sign on MRI (HP:0002419)1.98885711
69Abnormality of midbrain morphology (HP:0002418)1.98885711
70Reduced antithrombin III activity (HP:0001976)1.98491053
71Preaxial hand polydactyly (HP:0001177)1.96054159
72Optic nerve coloboma (HP:0000588)1.95829856
73Gaze-evoked nystagmus (HP:0000640)1.93995954
74Increased nuchal translucency (HP:0010880)1.93977801
75Truncal obesity (HP:0001956)1.92721872
76Arteriovenous malformation (HP:0100026)1.92486090
77Abnormality of the prostate (HP:0008775)1.91768616
78Abnormality of the columella (HP:0009929)1.91199706
79Bifid tongue (HP:0010297)1.88278538
80Aplasia/Hypoplasia of the tongue (HP:0010295)1.87812129
81Pancreatic cysts (HP:0001737)1.87738276
82Thyroid carcinoma (HP:0002890)1.87712107
83Lip pit (HP:0100267)1.86662365
84Oligodactyly (hands) (HP:0001180)1.86489070
85Median cleft lip (HP:0000161)1.86047723
86Lymphoma (HP:0002665)1.83722155
87Hypoplastic labia majora (HP:0000059)1.82837934
88Drooling (HP:0002307)1.82204230
89Aplasia/Hypoplasia of the tibia (HP:0005772)1.81478812
90Small hand (HP:0200055)1.80823801
91Fair hair (HP:0002286)1.76961767
92Degeneration of anterior horn cells (HP:0002398)1.76674037
93Abnormality of the anterior horn cell (HP:0006802)1.76674037
94Tracheoesophageal fistula (HP:0002575)1.76127342
95Shawl scrotum (HP:0000049)1.74882263
96Hyperventilation (HP:0002883)1.74667001
97Deep philtrum (HP:0002002)1.74191837
98Central scotoma (HP:0000603)1.73662405
99Aplasia/Hypoplasia of the sternum (HP:0006714)1.73552840
100Poor coordination (HP:0002370)1.73238359
101Sandal gap (HP:0001852)1.73100919
102Hepatoblastoma (HP:0002884)1.72983485
103Oral leukoplakia (HP:0002745)1.72953747
104Short middle phalanx of the 5th finger (HP:0004220)1.72795595
105Nephronophthisis (HP:0000090)1.72433381
106Scotoma (HP:0000575)1.72381136
107Pulmonary fibrosis (HP:0002206)1.72141034
108Selective tooth agenesis (HP:0001592)1.71303005
109Postaxial foot polydactyly (HP:0001830)1.71296259
110Short tibia (HP:0005736)1.70683143
111Abnormality of the incisor (HP:0000676)1.70627861
112Acute lymphatic leukemia (HP:0006721)1.70358155
113Abnormal protein glycosylation (HP:0012346)1.69893374
114Abnormal glycosylation (HP:0012345)1.69893374
115Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69893374
116Abnormal protein N-linked glycosylation (HP:0012347)1.69893374
117Aplasia/Hypoplasia of the earlobes (HP:0009906)1.69623533
118Abnormality of the phalanges of the hallux (HP:0010057)1.69495557
119Abnormality of the labia majora (HP:0012881)1.68010415
120Intestinal fistula (HP:0100819)1.67898968
121Medial flaring of the eyebrow (HP:0010747)1.67777620
122Cystic hygroma (HP:0000476)1.67145370
123Cerebellar dysplasia (HP:0007033)1.67086412
124IgG deficiency (HP:0004315)1.67084070
125Facial hemangioma (HP:0000329)1.65761429
126Pancytopenia (HP:0001876)1.65611309
127Gonadotropin excess (HP:0000837)1.65533482
128Horseshoe kidney (HP:0000085)1.64885266
129Papillary thyroid carcinoma (HP:0002895)1.64711826
130Oligohydramnios (HP:0001562)1.63261250
131Agnosia (HP:0010524)1.63213160
132Hypergonadotropic hypogonadism (HP:0000815)1.63096578
133Rhabdomyosarcoma (HP:0002859)1.62916528
134Abnormal biliary tract morphology (HP:0012440)1.62571921
135Neoplasm of the colon (HP:0100273)1.62397754
136Carpal bone hypoplasia (HP:0001498)1.62276493
137Genital tract atresia (HP:0001827)1.62091526
138Colon cancer (HP:0003003)1.61811192
139Abnormality of male internal genitalia (HP:0000022)1.61632219
140Embryonal neoplasm (HP:0002898)1.61453928
141Abnormality of chromosome segregation (HP:0002916)1.61331243
142Gastrointestinal atresia (HP:0002589)1.61015430
143High anterior hairline (HP:0009890)1.60022464
144Dandy-Walker malformation (HP:0001305)1.59916389
145Abnormality of incisor morphology (HP:0011063)1.59843249
146Lissencephaly (HP:0001339)1.59141844
147Cupped ear (HP:0000378)1.58700818
148Abnormality of the nasal septum (HP:0000419)1.58544352
149Abnormality of the pons (HP:0007361)1.56892997
150Excessive salivation (HP:0003781)1.56857697
151Breast carcinoma (HP:0003002)1.56807798
152Hypoplastic iliac wings (HP:0002866)1.56786192
153Neoplasm of the oral cavity (HP:0100649)1.56498564
154Highly arched eyebrow (HP:0002553)1.55864814

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.88163467
2FRK3.64014487
3SRPK13.29763289
4WEE13.27377102
5BRSK22.95226423
6ACVR1B2.92511607
7MKNK22.82170938
8PLK42.68276188
9MKNK12.58530845
10BUB12.45124660
11TRIM282.29928116
12PNCK2.22323263
13AKT32.19018368
14ZAK2.09465100
15TSSK61.94155481
16VRK11.89533399
17PLK31.80212918
18MAP3K41.79445375
19CASK1.78486423
20PLK11.73637048
21ATR1.72240297
22STK38L1.67908386
23STK161.64119574
24INSRR1.63395760
25CDK81.62279606
26CLK11.62279549
27TTK1.61094100
28EIF2AK31.60255784
29CAMK1G1.58322357
30BRSK11.57395100
31CCNB11.55261918
32NEK21.54927121
33STK241.53871820
34PBK1.52178461
35TAF11.51763384
36EIF2AK21.49136775
37EIF2AK11.46572822
38MUSK1.44470809
39PASK1.40433902
40TXK1.38575853
41WNK31.37009846
42IRAK31.36941434
43CHEK21.36399905
44TLK11.35244885
45CDK71.32199716
46BCR1.26516974
47AURKB1.25116777
48YES11.21314454
49CDK31.17158886
50NUAK11.16645119
51IRAK41.13643464
52CHEK11.12302706
53STK31.09997073
54PIM11.07103142
55TEC1.07094134
56ATM1.06002401
57STK41.01967715
58BMPR21.00892452
59TNIK0.99994090
60BRD40.98792989
61PRPF4B0.97727371
62MAP3K140.97516676
63DYRK30.96474727
64NEK60.91896046
65ERBB30.91124654
66SGK20.90080147
67CAMK1D0.88932856
68CDK120.87419872
69NLK0.83294886
70MAP3K90.81415812
71CHUK0.80959073
72TGFBR10.78556736
73MAP4K20.75559030
74PIM20.73735663
75BMPR1B0.72634123
76PLK20.71399575
77CDK20.70461126
78RPS6KA40.69054020
79CDK10.67517795
80CSNK2A10.64371271
81CSNK1G10.63359416
82STK390.63298992
83CDK40.63169547
84RPS6KB10.62731034
85MELK0.62520729
86RPS6KB20.62517761
87OXSR10.62369778
88CAMKK20.62124669
89IKBKB0.61182667
90SIK30.60668563
91FGFR10.60447099
92NEK90.60198837
93FGFR20.58468696
94AURKA0.58170193
95BRAF0.58078578
96ERBB40.57114244
97EEF2K0.53706003
98MAP2K30.53185178
99CSNK2A20.51543909
100ADRBK20.50601747
101MAP3K60.50577947
102PDK20.50253551
103PINK10.49920791
104CSNK1D0.48780897
105TAOK20.48283104
106KIT0.46985430
107CDK90.46843007
108BTK0.46537179
109MET0.45626105
110MAP2K70.45625126
111OBSCN0.44581010
112CSNK1E0.43970511
113PAK30.43395147
114RPS6KA50.42899604
115PIK3CG0.41109476
116CSNK1A1L0.40228195
117MAP3K30.37908580
118JAK30.37260446
119MAPK130.36123065
120PRKAA10.34860440
121MAP3K100.34561254
122MAPK140.34509372
123STK100.34236270
124MST40.33833416
125KSR10.33697661
126LATS10.33461653
127PRKCE0.31606551
128CSNK1G20.31304973
129AKT10.30158191
130MARK30.29451123
131PRKDC0.29304860
132RPS6KA60.27785712
133GSK3B0.27143288
134NEK10.26282840
135MAP4K10.26129251

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.66211276
2Mismatch repair_Homo sapiens_hsa034304.01520876
3Homologous recombination_Homo sapiens_hsa034403.85510722
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.58597639
5Base excision repair_Homo sapiens_hsa034103.34842375
6Fanconi anemia pathway_Homo sapiens_hsa034603.33355488
7Cell cycle_Homo sapiens_hsa041103.00970767
8RNA polymerase_Homo sapiens_hsa030203.00318803
9Basal transcription factors_Homo sapiens_hsa030222.94424458
10Nucleotide excision repair_Homo sapiens_hsa034202.81966761
11Non-homologous end-joining_Homo sapiens_hsa034502.79408591
12Spliceosome_Homo sapiens_hsa030402.70431882
13RNA transport_Homo sapiens_hsa030132.51371197
14Pyrimidine metabolism_Homo sapiens_hsa002402.18806606
15One carbon pool by folate_Homo sapiens_hsa006702.16298350
16RNA degradation_Homo sapiens_hsa030182.09774104
17Proteasome_Homo sapiens_hsa030501.77727414
18mRNA surveillance pathway_Homo sapiens_hsa030151.70001503
19p53 signaling pathway_Homo sapiens_hsa041151.65117983
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64867632
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58912765
22Purine metabolism_Homo sapiens_hsa002301.51496694
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49739624
24Lysine degradation_Homo sapiens_hsa003101.46208754
25Propanoate metabolism_Homo sapiens_hsa006401.39609319
26Herpes simplex infection_Homo sapiens_hsa051681.31475506
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17635143
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.17355940
29Ribosome_Homo sapiens_hsa030101.15405099
30Epstein-Barr virus infection_Homo sapiens_hsa051691.09719278
31Vitamin B6 metabolism_Homo sapiens_hsa007501.08550697
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07852011
33Fatty acid biosynthesis_Homo sapiens_hsa000611.03249517
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02383061
35NF-kappa B signaling pathway_Homo sapiens_hsa040640.99855828
36Thyroid cancer_Homo sapiens_hsa052160.96563354
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95835815
38Protein export_Homo sapiens_hsa030600.95368794
39Primary immunodeficiency_Homo sapiens_hsa053400.94686267
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93648724
41Viral carcinogenesis_Homo sapiens_hsa052030.89275283
42Systemic lupus erythematosus_Homo sapiens_hsa053220.88661233
43Butanoate metabolism_Homo sapiens_hsa006500.86658444
44Steroid biosynthesis_Homo sapiens_hsa001000.85659302
45Intestinal immune network for IgA production_Homo sapiens_hsa046720.83402072
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80943663
47Measles_Homo sapiens_hsa051620.80094353
48Olfactory transduction_Homo sapiens_hsa047400.78557302
49HTLV-I infection_Homo sapiens_hsa051660.75965211
50Taste transduction_Homo sapiens_hsa047420.73015454
51Antigen processing and presentation_Homo sapiens_hsa046120.70755195
52Oocyte meiosis_Homo sapiens_hsa041140.68642566
53Dorso-ventral axis formation_Homo sapiens_hsa043200.67695651
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66961055
55Arachidonic acid metabolism_Homo sapiens_hsa005900.65327249
56MicroRNAs in cancer_Homo sapiens_hsa052060.63390085
57Phototransduction_Homo sapiens_hsa047440.63233760
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63007441
59Hedgehog signaling pathway_Homo sapiens_hsa043400.62945595
60Asthma_Homo sapiens_hsa053100.62293017
61Autoimmune thyroid disease_Homo sapiens_hsa053200.62048203
62Nitrogen metabolism_Homo sapiens_hsa009100.61790749
63Small cell lung cancer_Homo sapiens_hsa052220.61533799
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61452111
65Influenza A_Homo sapiens_hsa051640.60955735
66Hematopoietic cell lineage_Homo sapiens_hsa046400.58923764
67Allograft rejection_Homo sapiens_hsa053300.57430204
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55333764
69Legionellosis_Homo sapiens_hsa051340.54363154
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54158651
71Nicotine addiction_Homo sapiens_hsa050330.51061111
72TGF-beta signaling pathway_Homo sapiens_hsa043500.49967886
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.47749462
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47471112
75N-Glycan biosynthesis_Homo sapiens_hsa005100.47212414
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47180313
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46734372
78Vitamin digestion and absorption_Homo sapiens_hsa049770.45243017
79Hepatitis B_Homo sapiens_hsa051610.44497095
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42823507
81Circadian rhythm_Homo sapiens_hsa047100.42156511
82ABC transporters_Homo sapiens_hsa020100.41572528
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40749144
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40630322
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40532688
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40314789
87Basal cell carcinoma_Homo sapiens_hsa052170.39939297
88Fatty acid metabolism_Homo sapiens_hsa012120.39380422
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39192157
90Endometrial cancer_Homo sapiens_hsa052130.37393100
91Graft-versus-host disease_Homo sapiens_hsa053320.37281054
92Tryptophan metabolism_Homo sapiens_hsa003800.36913101
93Pyruvate metabolism_Homo sapiens_hsa006200.36547394
94Folate biosynthesis_Homo sapiens_hsa007900.35738854
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33881976
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.33654070
97Linoleic acid metabolism_Homo sapiens_hsa005910.33495204
98Apoptosis_Homo sapiens_hsa042100.33210495
99Alcoholism_Homo sapiens_hsa050340.33073753
100Selenocompound metabolism_Homo sapiens_hsa004500.33032512
101Pathways in cancer_Homo sapiens_hsa052000.32500327
102Prostate cancer_Homo sapiens_hsa052150.31755940
103Regulation of autophagy_Homo sapiens_hsa041400.30803697
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30440447
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.28770596
106Notch signaling pathway_Homo sapiens_hsa043300.28759170
107Non-small cell lung cancer_Homo sapiens_hsa052230.28069297
108Glioma_Homo sapiens_hsa052140.28052122
109Ether lipid metabolism_Homo sapiens_hsa005650.27787275
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27072283
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27001032
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26825583
113Wnt signaling pathway_Homo sapiens_hsa043100.25135796
114Colorectal cancer_Homo sapiens_hsa052100.24997075
115Hippo signaling pathway_Homo sapiens_hsa043900.23767185
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22970676
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22794379
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22088039
119Sphingolipid metabolism_Homo sapiens_hsa006000.21987351
120Tight junction_Homo sapiens_hsa045300.20957415
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20024732
122mTOR signaling pathway_Homo sapiens_hsa041500.19733082
123FoxO signaling pathway_Homo sapiens_hsa040680.19596454
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19092412
125Type II diabetes mellitus_Homo sapiens_hsa049300.18594665
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.17981334
127Melanoma_Homo sapiens_hsa052180.17057732
128Adherens junction_Homo sapiens_hsa045200.16582185
129Long-term depression_Homo sapiens_hsa047300.16296690
130Type I diabetes mellitus_Homo sapiens_hsa049400.15795790
131Leishmaniasis_Homo sapiens_hsa051400.15581359
132Pancreatic cancer_Homo sapiens_hsa052120.15320411
133Glycerolipid metabolism_Homo sapiens_hsa005610.15056223
134Choline metabolism in cancer_Homo sapiens_hsa052310.14986113
135Inositol phosphate metabolism_Homo sapiens_hsa005620.14556098
136beta-Alanine metabolism_Homo sapiens_hsa004100.14394151
137Huntingtons disease_Homo sapiens_hsa050160.14020804
138TNF signaling pathway_Homo sapiens_hsa046680.12681730
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.12599076
140Metabolic pathways_Homo sapiens_hsa011000.12032289
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.11896164
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.11330832
143Toll-like receptor signaling pathway_Homo sapiens_hsa046200.11148421

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