USP38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1monoubiquitinated protein deubiquitination (GO:0035520)4.70928586
2nuclear pore complex assembly (GO:0051292)4.52657483
3regulation of gamma-delta T cell differentiation (GO:0045586)4.38723681
4nuclear pore organization (GO:0006999)4.37156599
5regulation of RNA export from nucleus (GO:0046831)4.15274298
6histone H2A monoubiquitination (GO:0035518)4.08417567
7mitotic sister chromatid cohesion (GO:0007064)4.06097618
8positive regulation of gamma-delta T cell activation (GO:0046645)4.05978083
9actin-myosin filament sliding (GO:0033275)3.98763535
10muscle filament sliding (GO:0030049)3.98763535
11CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.96433803
12T-helper cell differentiation (GO:0042093)3.96433803
13positive regulation of granulocyte differentiation (GO:0030854)3.95287007
14regulation of gamma-delta T cell activation (GO:0046643)3.94313451
15negative regulation of T-helper cell differentiation (GO:0045623)3.77763989
16negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.77763989
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.76657701
18positive thymic T cell selection (GO:0045059)3.76047610
19mitotic chromosome condensation (GO:0007076)3.68245428
20skeletal muscle contraction (GO:0003009)3.66609018
21embryonic process involved in female pregnancy (GO:0060136)3.62915729
22skeletal muscle adaptation (GO:0043501)3.61380201
23mitotic metaphase plate congression (GO:0007080)3.60567482
24regulation of spindle organization (GO:0090224)3.57105371
25negative T cell selection (GO:0043383)3.55718626
26regulation of nucleobase-containing compound transport (GO:0032239)3.54057220
27CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.53706763
28actin-mediated cell contraction (GO:0070252)3.53396770
29regulation of necroptotic process (GO:0060544)3.48666718
30negative regulation of necroptotic process (GO:0060546)3.44126430
31regulation of relaxation of muscle (GO:1901077)3.44090012
32sarcoplasmic reticulum calcium ion transport (GO:0070296)3.42289760
33negative thymic T cell selection (GO:0045060)3.39934180
34pore complex assembly (GO:0046931)3.38600150
35negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.33355616
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.33186951
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.33186951
38actin filament-based movement (GO:0030048)3.30692721
39negative regulation of histone methylation (GO:0031061)3.26178316
40T cell differentiation involved in immune response (GO:0002292)3.25052687
41alpha-beta T cell differentiation involved in immune response (GO:0002293)3.25052687
42alpha-beta T cell activation involved in immune response (GO:0002287)3.25052687
43positive regulation of chromosome segregation (GO:0051984)3.24939233
44mitotic nuclear envelope disassembly (GO:0007077)3.24328056
45regulation of interleukin-12 biosynthetic process (GO:0045075)3.20936632
46phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.20766439
47positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.18551208
48thymic T cell selection (GO:0045061)3.16919420
49regulation of podosome assembly (GO:0071801)3.16506943
50negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.16323568
51negative regulation of cell killing (GO:0031342)3.16323568
52hepatocyte apoptotic process (GO:0097284)3.11790673
53cellular response to arsenic-containing substance (GO:0071243)3.10661571
54DNA damage induced protein phosphorylation (GO:0006975)3.09028842
55negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.06973994
56positive T cell selection (GO:0043368)3.04995792
57regulation of sister chromatid cohesion (GO:0007063)3.03257504
58metaphase plate congression (GO:0051310)3.02808629
59nuclear envelope disassembly (GO:0051081)3.02361696
60membrane disassembly (GO:0030397)3.02361696
61regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.01513733
62histone H2A ubiquitination (GO:0033522)3.00957737
63interferon-gamma production (GO:0032609)2.99521148
64protein localization to kinetochore (GO:0034501)2.99301668
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.99050468
66regulation of response to interferon-gamma (GO:0060330)2.98631504
67regulation of mitotic spindle organization (GO:0060236)2.96953348
68regulation of transforming growth factor beta2 production (GO:0032909)2.96931265
69negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.95948226
70protein localization to chromosome, centromeric region (GO:0071459)2.95458000
71folic acid-containing compound biosynthetic process (GO:0009396)2.95082595
72response to interleukin-15 (GO:0070672)2.93264956
73antigen processing and presentation of endogenous antigen (GO:0019883)2.92758104
74CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.92151160
75NIK/NF-kappaB signaling (GO:0038061)2.91012678
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90933542
77cytokine production involved in immune response (GO:0002367)2.89808881
78histone mRNA catabolic process (GO:0071044)2.85348845
79folic acid metabolic process (GO:0046655)2.80522892
80T cell selection (GO:0045058)2.80237344
81cytoplasmic mRNA processing body assembly (GO:0033962)2.79715454
82response to muramyl dipeptide (GO:0032495)2.74753044
83regulation of granulocyte differentiation (GO:0030852)2.73869300
84striated muscle atrophy (GO:0014891)2.72365923
85establishment of chromosome localization (GO:0051303)2.71614057
86regulation of retinoic acid receptor signaling pathway (GO:0048385)2.71573774
87JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.70499754
88regulation of NFAT protein import into nucleus (GO:0051532)2.69849559
89tyrosine phosphorylation of STAT protein (GO:0007260)2.68979073
90ribosome assembly (GO:0042255)2.66274445
91regulation of translational termination (GO:0006449)2.63943822
92negative regulation of alpha-beta T cell differentiation (GO:0046639)2.63826088
93response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.63812204
94protein localization to chromosome (GO:0034502)2.63293618
95regulation of histone H3-K27 methylation (GO:0061085)2.62560002
96histone H3-K36 demethylation (GO:0070544)2.62379225
97positive regulation of chemokine biosynthetic process (GO:0045080)2.62036365
98Rap protein signal transduction (GO:0032486)2.61220802
99negative regulation of NF-kappaB import into nucleus (GO:0042347)2.59706565
100response to laminar fluid shear stress (GO:0034616)2.59091304
101negative regulation of neurotransmitter secretion (GO:0046929)2.58575857
102nuclear envelope organization (GO:0006998)2.58174127
1033-UTR-mediated mRNA stabilization (GO:0070935)2.57366002
104sarcomere organization (GO:0045214)2.57130001
105germinal center formation (GO:0002467)2.56947190
106pre-miRNA processing (GO:0031054)2.55478230
107positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.55375860
108positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.55375860
109positive regulation of mitotic sister chromatid separation (GO:1901970)2.55375860
110dosage compensation (GO:0007549)2.55036489
111regulation of fibroblast apoptotic process (GO:2000269)2.54684581
112histone monoubiquitination (GO:0010390)2.54521505
113regulation of skeletal muscle contraction (GO:0014819)2.52448554
114T cell costimulation (GO:0031295)2.52404210
115protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.52207668
116cellular extravasation (GO:0045123)2.52183900
117myofibril assembly (GO:0030239)2.51873079
118muscle organ morphogenesis (GO:0048644)2.51374183
119cellular response to interleukin-15 (GO:0071350)2.51269353
120negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.50628967
121CD4-positive, alpha-beta T cell activation (GO:0035710)2.49927941
122negative regulation of potassium ion transmembrane transport (GO:1901380)2.49280017
123carnitine shuttle (GO:0006853)2.48827974
124positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.48604371
125lymphocyte costimulation (GO:0031294)2.47333662
126response to peptidoglycan (GO:0032494)2.46873869
127positive regulation of DNA-templated transcription, initiation (GO:2000144)2.45229973
128DNA replication checkpoint (GO:0000076)2.45206973
129regulation of immunoglobulin secretion (GO:0051023)2.44334661
130response to mercury ion (GO:0046689)2.44308105
131attachment of spindle microtubules to kinetochore (GO:0008608)2.44094622
132nerve growth factor signaling pathway (GO:0038180)2.43637619
133COPII vesicle coating (GO:0048208)2.43302336
134definitive hemopoiesis (GO:0060216)2.42900295
135protein K48-linked deubiquitination (GO:0071108)2.42829349
136necroptotic process (GO:0070266)2.41793633
137growth hormone receptor signaling pathway (GO:0060396)2.41426253
138regulation of histone H3-K9 methylation (GO:0051570)2.41028117
139mRNA modification (GO:0016556)2.40723275
140regulation of type I interferon-mediated signaling pathway (GO:0060338)2.39861795
141corticosteroid receptor signaling pathway (GO:0031958)2.39238156
142protein localization to microtubule (GO:0035372)2.39121459
143sister chromatid cohesion (GO:0007062)2.38811765
144gonadal mesoderm development (GO:0007506)2.38780332
145tolerance induction (GO:0002507)2.38587936
146T cell lineage commitment (GO:0002360)2.38284439
147microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.36459296
148negative regulation of anoikis (GO:2000811)2.36379942
149regulation of alpha-beta T cell proliferation (GO:0046640)2.35605690
150T cell receptor signaling pathway (GO:0050852)2.35099449
151response to inactivity (GO:0014854)2.34604447
152muscle atrophy (GO:0014889)2.34364555
153regulation of RIG-I signaling pathway (GO:0039535)2.33679441
154positive regulation of protein import into nucleus, translocation (GO:0033160)2.33445269
155positive regulation of B cell proliferation (GO:0030890)2.33147668
156nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.32624284
157regulation of B cell receptor signaling pathway (GO:0050855)2.32531257
158nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.32528726
159T cell activation involved in immune response (GO:0002286)2.31989613
160B cell homeostasis (GO:0001782)2.31889154
161response to UV-C (GO:0010225)2.31391200
162positive regulation of interleukin-2 production (GO:0032743)2.30446539
163positive regulation of humoral immune response (GO:0002922)2.30416464
164production of molecular mediator of immune response (GO:0002440)2.30328451
165response to arsenic-containing substance (GO:0046685)2.28804233
166interleukin-6-mediated signaling pathway (GO:0070102)2.28438861
167positive regulation of isotype switching (GO:0045830)2.28312969
168N-terminal protein amino acid acetylation (GO:0006474)2.28311172
169striated muscle contraction (GO:0006941)2.27894698
170negative regulation of necrotic cell death (GO:0060547)2.27700494
171regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.27380960
172hypotonic response (GO:0006971)2.26389305
173nucleobase biosynthetic process (GO:0046112)2.26027955
174protein K63-linked deubiquitination (GO:0070536)2.25717566
175DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.25068987
176NLS-bearing protein import into nucleus (GO:0006607)2.24600944
177histone lysine demethylation (GO:0070076)2.24472996
178T cell migration (GO:0072678)2.24464677
179DNA damage response, signal transduction resulting in transcription (GO:0042772)2.24183777
180protein K6-linked ubiquitination (GO:0085020)2.24089005
181chromatin assembly or disassembly (GO:0006333)2.23803832
182histone phosphorylation (GO:0016572)2.23175920
183regulation of chromosome segregation (GO:0051983)2.23082207
184carnitine transmembrane transport (GO:1902603)2.22896253
185regulation of isotype switching to IgG isotypes (GO:0048302)2.22673751
186DNA unwinding involved in DNA replication (GO:0006268)2.22623350
187response to muscle activity (GO:0014850)2.21805586
188regulation of necrotic cell death (GO:0010939)2.21546257
189negative regulation of erythrocyte differentiation (GO:0045647)2.21223940
190detection of molecule of bacterial origin (GO:0032490)2.20756551
191positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.19746658

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.35417904
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.92526484
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.51568947
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.35338595
5MYC_22102868_ChIP-Seq_BL_Human3.25853973
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.16521626
7GATA1_22025678_ChIP-Seq_K562_Human2.97913680
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65698229
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.65147837
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.50265159
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38634331
12* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.36715338
13* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.35172103
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.19964441
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.02397192
16AR_21909140_ChIP-Seq_LNCAP_Human1.97920057
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.95729932
18MYB_26560356_Chip-Seq_TH2_Human1.89028943
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88303784
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.84371019
21MYB_26560356_Chip-Seq_TH1_Human1.83938133
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.83012701
23* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81110504
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80314877
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76996799
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73763921
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73351457
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73220254
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71360551
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71360551
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.67744856
32MAF_26560356_Chip-Seq_TH1_Human1.65558107
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.63255970
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63100496
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61458402
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60842051
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58596255
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56992026
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.56453292
40TCF7_22412390_ChIP-Seq_EML_Mouse1.56104277
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.55895157
42UTX_26944678_Chip-Seq_JUKART_Human1.53093120
43VDR_24787735_ChIP-Seq_THP-1_Human1.53024873
44CLOCK_20551151_ChIP-Seq_293T_Human1.52002042
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.51743819
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.51743819
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.49115476
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.48790778
49RUNX_20019798_ChIP-Seq_JUKART_Human1.48612800
50* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48458531
51VDR_21846776_ChIP-Seq_THP-1_Human1.46918310
52KDM5A_27292631_Chip-Seq_BREAST_Human1.46328112
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45574847
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40921509
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40467138
56ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.40370478
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39783778
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39666837
59* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37625720
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.37603332
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35244485
62VDR_23849224_ChIP-Seq_CD4+_Human1.35143366
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33294751
64ZNF263_19887448_ChIP-Seq_K562_Human1.33246655
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.33105987
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.32887966
67PU_27001747_Chip-Seq_BMDM_Mouse1.31713776
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30695264
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.29400662
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.28464203
71RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.28311651
72MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28061650
73CIITA_25753668_ChIP-Seq_RAJI_Human1.27952310
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26099576
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26038107
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25403470
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23794875
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23403968
79* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22815721
80GATA3_27048872_Chip-Seq_THYMUS_Human1.22664971
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22087415
82MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21314951
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.19962155
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19791412
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.19543693
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.19047961
87FOXP3_21729870_ChIP-Seq_TREG_Human1.17572984
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15863473
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15643348
90BRD4_25478319_ChIP-Seq_HGPS_Human1.15141848
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15131220
92FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14988073
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14725143
94SPI1_23547873_ChIP-Seq_NB4_Human1.13936582
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12643347
96HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11649395
97MAF_26560356_Chip-Seq_TH2_Human1.10819156
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10251285
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09599566
100* KDM2B_26808549_Chip-Seq_DND41_Human1.09358452
101TBX20_22328084_ChIP-Seq_HEART_Mouse1.07181510
102TBX20_22080862_ChIP-Seq_HEART_Mouse1.07181510
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07111011
104SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06720025
105LXR_22158963_ChIP-Seq_LIVER_Mouse1.06382039
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06247681
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05627015
108SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05615353
109RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04991457
110STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04979421
111FOXO3_23340844_ChIP-Seq_DLD1_Human1.04635743
112SMAD_19615063_ChIP-ChIP_OVARY_Human1.04579424
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04571171
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03491824
115TP53_16413492_ChIP-PET_HCT116_Human1.03430006
116* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02942439
117EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02126446
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01938619
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01783154
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01083629
121* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00996994
122CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00781931
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00390074
124ER_23166858_ChIP-Seq_MCF-7_Human1.00252719
125CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00155107
126GATA2_19941826_ChIP-Seq_K562_Human1.00054997
127CJUN_26792858_Chip-Seq_BT549_Human0.99676809
128IRF8_27001747_Chip-Seq_BMDM_Mouse0.98753138
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98178117
130GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98086314
131NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97990764
132TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97307469
133FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97147508
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96032851
135* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95708701
136TP63_23658742_ChIP-Seq_EP156T_Human0.94640801
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94126472
138SCL_19346495_ChIP-Seq_HPC-7_Human0.93694154
139FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93482022
140XRN2_22483619_ChIP-Seq_HELA_Human0.93263237
141VDR_24763502_ChIP-Seq_THP-1_Human0.92907136
142ATF3_27146783_Chip-Seq_COLON_Human0.92783568
143CDX2_22108803_ChIP-Seq_LS180_Human0.92230904
144FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91847826
145TFEB_21752829_ChIP-Seq_HELA_Human0.91603794
146* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90634373
147GABP_19822575_ChIP-Seq_HepG2_Human0.90557553
148POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.90449216
149GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90413237
150RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89990180
151* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89638397
152CHD1_26751641_Chip-Seq_LNCaP_Human0.89297623
153IRF8_21731497_ChIP-ChIP_J774_Mouse0.88956001
154EST1_17652178_ChIP-ChIP_JURKAT_Human0.88586248
155MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88246260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.20432532
2MP0008057_abnormal_DNA_replication3.01592278
3MP0003693_abnormal_embryo_hatching2.57858665
4MP0003646_muscle_fatigue2.53775743
5MP0003077_abnormal_cell_cycle2.48279405
6MP0010094_abnormal_chromosome_stability2.48150095
7MP0003828_pulmonary_edema2.36912304
8MP0002332_abnormal_exercise_endurance2.36484329
9MP0003111_abnormal_nucleus_morphology2.31280450
10MP0010352_gastrointestinal_tract_polyps2.20203951
11MP0002396_abnormal_hematopoietic_system2.17214951
12MP0000749_muscle_degeneration2.17192900
13MP0001800_abnormal_humoral_immune2.16076351
14MP0010307_abnormal_tumor_latency2.08802091
15MP0004145_abnormal_muscle_electrophysio2.05511514
16MP0000685_abnormal_immune_system2.04724161
17MP0002166_altered_tumor_susceptibility2.03360458
18MP0004957_abnormal_blastocyst_morpholog1.99102318
19MP0005671_abnormal_response_to1.96519128
20MP0004233_abnormal_muscle_weight1.95136201
21MP0004036_abnormal_muscle_relaxation1.92118957
22MP0002398_abnormal_bone_marrow1.92077140
23MP0003191_abnormal_cellular_cholesterol1.90203884
24MP0004808_abnormal_hematopoietic_stem1.82038369
25MP0003303_peritoneal_inflammation1.80900209
26MP0003950_abnormal_plasma_membrane1.80843414
27MP0005451_abnormal_body_composition1.79060348
28MP0003300_gastrointestinal_ulcer1.79039194
29MP0001730_embryonic_growth_arrest1.76017845
30MP0009333_abnormal_splenocyte_physiolog1.74293645
31MP0002006_tumorigenesis1.72792891
32MP0008007_abnormal_cellular_replicative1.72144049
33MP0004087_abnormal_muscle_fiber1.70541530
34MP0009840_abnormal_foam_cell1.69670480
35MP0000689_abnormal_spleen_morphology1.68291362
36MP0000703_abnormal_thymus_morphology1.67528983
37MP0002723_abnormal_immune_serum1.64092117
38MP0004185_abnormal_adipocyte_glucose1.62838764
39MP0002405_respiratory_system_inflammati1.62788913
40MP0000759_abnormal_skeletal_muscle1.62556063
41MP0002452_abnormal_antigen_presenting1.62310339
42MP0001790_abnormal_immune_system1.61398525
43MP0005387_immune_system_phenotype1.61398525
44MP0004484_altered_response_of1.59423956
45MP0002420_abnormal_adaptive_immunity1.59384564
46MP0002722_abnormal_immune_system1.58413597
47MP0000716_abnormal_immune_system1.56141909
48MP0005076_abnormal_cell_differentiation1.56077614
49MP0001819_abnormal_immune_cell1.55780153
50MP0005397_hematopoietic_system_phenotyp1.52952543
51MP0001545_abnormal_hematopoietic_system1.52952543
52MP0005365_abnormal_bile_salt1.52675851
53MP0001835_abnormal_antigen_presentation1.52513572
54MP0003436_decreased_susceptibility_to1.52290091
55MP0000350_abnormal_cell_proliferation1.52236286
56MP0000013_abnormal_adipose_tissue1.52013597
57MP0002139_abnormal_hepatobiliary_system1.51927332
58MP0000747_muscle_weakness1.50984425
59MP0005000_abnormal_immune_tolerance1.50857283
60MP0004947_skin_inflammation1.49967553
61MP0008058_abnormal_DNA_repair1.47653838
62MP0004084_abnormal_cardiac_muscle1.47211556
63MP0001873_stomach_inflammation1.46651786
64MP0003091_abnormal_cell_migration1.45856033
65MP0002106_abnormal_muscle_physiology1.44706911
66MP0000751_myopathy1.44559080
67MP0010678_abnormal_skin_adnexa1.40854308
68MP0000733_abnormal_muscle_development1.39784980
69MP0002269_muscular_atrophy1.39380829
70MP0005310_abnormal_salivary_gland1.37722922
71MP0002019_abnormal_tumor_incidence1.37038232
72MP0002009_preneoplasia1.36959145
73MP0005360_urolithiasis1.35836656
74MP0000609_abnormal_liver_physiology1.34189000
75MP0002429_abnormal_blood_cell1.33727786
76MP0004130_abnormal_muscle_cell1.28433632
77MP0003705_abnormal_hypodermis_morpholog1.27851018
78MP0010155_abnormal_intestine_physiology1.27768014
79MP0010234_abnormal_vibrissa_follicle1.26996380
80MP0003252_abnormal_bile_duct1.25858713
81MP0005380_embryogenesis_phenotype1.25487588
82MP0001672_abnormal_embryogenesis/_devel1.25487588
83MP0002971_abnormal_brown_adipose1.21171582
84MP0003984_embryonic_growth_retardation1.19380363
85MP0003656_abnormal_erythrocyte_physiolo1.18111215
86MP0002088_abnormal_embryonic_growth/wei1.17936330
87MP0002086_abnormal_extraembryonic_tissu1.16167671
88MP0000490_abnormal_crypts_of1.15849688
89MP0005620_abnormal_muscle_contractility1.14853068
90MP0000465_gastrointestinal_hemorrhage1.12883296
91MP0009115_abnormal_fat_cell1.12809593
92MP0009278_abnormal_bone_marrow1.12725014
93MP0001845_abnormal_inflammatory_respons1.12119033
94MP0003718_maternal_effect1.10508064
95MP0001697_abnormal_embryo_size1.09481925
96MP0005025_abnormal_response_to1.06776826
97MP0002138_abnormal_hepatobiliary_system1.06564335
98MP0001853_heart_inflammation1.06260108
99MP0003724_increased_susceptibility_to1.04809118
100MP0005330_cardiomyopathy1.04756757
101MP0002419_abnormal_innate_immunity1.03979383
102MP0002972_abnormal_cardiac_muscle1.03684545
103MP0010630_abnormal_cardiac_muscle1.03248911
104MP0002877_abnormal_melanocyte_morpholog1.01697200
105MP0005369_muscle_phenotype1.00911579
106MP0002796_impaired_skin_barrier1.00869912
107MP0008877_abnormal_DNA_methylation1.00637726
108MP0001348_abnormal_lacrimal_gland0.99963656
109MP0006082_CNS_inflammation0.99682894
110MP0003806_abnormal_nucleotide_metabolis0.98531317
111MP0003183_abnormal_peptide_metabolism0.98350174
112MP0003045_fibrosis0.97148052
113MP0005621_abnormal_cell_physiology0.94411862
114MP0003448_altered_tumor_morphology0.93171195
115MP0004264_abnormal_extraembryonic_tissu0.92919934
116MP0009785_altered_susceptibility_to0.92673347
117MP0005166_decreased_susceptibility_to0.92565220
118MP0005023_abnormal_wound_healing0.92112361
119MP0000750_abnormal_muscle_regeneration0.91927356
120MP0002080_prenatal_lethality0.91777131
121MP0005085_abnormal_gallbladder_physiolo0.88934457
122MP0006138_congestive_heart_failure0.88730300
123MP0001851_eye_inflammation0.88547062
124MP0003866_abnormal_defecation0.85485258
125MP0000383_abnormal_hair_follicle0.84769551
126MP0002084_abnormal_developmental_patter0.84139509
127MP0000003_abnormal_adipose_tissue0.83450101
128MP0000598_abnormal_liver_morphology0.82872529
129MP0002085_abnormal_embryonic_tissue0.82803225
130MP0000313_abnormal_cell_death0.82316718
131MP0004510_myositis0.82236302
132MP0005375_adipose_tissue_phenotype0.82187489
133MP0001191_abnormal_skin_condition0.81687713
134MP0001915_intracranial_hemorrhage0.81644165
135MP0005266_abnormal_metabolism0.81245944
136MP0000858_altered_metastatic_potential0.80411734
137MP0005501_abnormal_skin_physiology0.79680810
138MP0002933_joint_inflammation0.79487440
139MP0003453_abnormal_keratinocyte_physiol0.79226130
140MP0003221_abnormal_cardiomyocyte_apopto0.78466846
141MP0005666_abnormal_adipose_tissue0.77941697
142MP0001533_abnormal_skeleton_physiology0.77880704
143MP0004197_abnormal_fetal_growth/weight/0.77836549
144MP0001216_abnormal_epidermal_layer0.76652599
145MP0008961_abnormal_basal_metabolism0.73786933
146MP0002998_abnormal_bone_remodeling0.71506806
147MP0003868_abnormal_feces_composition0.71279711
148MP0002127_abnormal_cardiovascular_syste0.69645047

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.17355040
2Nemaline bodies (HP:0003798)7.01906924
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.96352314
4Exercise-induced myalgia (HP:0003738)5.60689467
5Exercise-induced muscle cramps (HP:0003710)4.64507569
6Type 1 muscle fiber predominance (HP:0003803)4.64058886
7Abnormality of the left ventricular outflow tract (HP:0011103)4.51217070
8Subaortic stenosis (HP:0001682)4.51217070
9EMG: myopathic abnormalities (HP:0003458)4.08044646
10T lymphocytopenia (HP:0005403)4.04523570
11Abnormality of T cell number (HP:0011839)3.81495788
12Abnormality of the fingertips (HP:0001211)3.79256788
13Difficulty running (HP:0009046)3.75293287
14Hyporeflexia of lower limbs (HP:0002600)3.63868106
15Muscle hypertrophy of the lower extremities (HP:0008968)3.44200748
16Birth length less than 3rd percentile (HP:0003561)3.40432414
17Combined immunodeficiency (HP:0005387)3.37153224
18Muscle fiber splitting (HP:0003555)3.35229835
19Centrally nucleated skeletal muscle fibers (HP:0003687)3.27590646
20Severe combined immunodeficiency (HP:0004430)3.26153826
21Calf muscle hypertrophy (HP:0008981)3.24961507
22Recurrent viral infections (HP:0004429)3.20606108
23Rhabdomyolysis (HP:0003201)3.13695620
24Myoglobinuria (HP:0002913)3.06226386
25Distal arthrogryposis (HP:0005684)3.02309840
26Abnormality of the calf musculature (HP:0001430)3.01533853
27Neck muscle weakness (HP:0000467)2.97317721
28Myopathic facies (HP:0002058)2.95489605
29Myocardial infarction (HP:0001658)2.95460546
30Abnormality of T cells (HP:0002843)2.93335746
31Abnormality of skeletal muscle fiber size (HP:0012084)2.92606376
32Thyroiditis (HP:0100646)2.86428458
33Recurrent fungal infections (HP:0002841)2.82405570
34Rimmed vacuoles (HP:0003805)2.81512245
35IgG deficiency (HP:0004315)2.72357386
36Facial hemangioma (HP:0000329)2.70971292
37Entropion (HP:0000621)2.69354516
38Subacute progressive viral hepatitis (HP:0006572)2.66743496
39IgM deficiency (HP:0002850)2.62692315
40Stomatitis (HP:0010280)2.62026127
41Increased connective tissue (HP:0009025)2.61676177
42Curly hair (HP:0002212)2.61217061
43Small epiphyses (HP:0010585)2.59450061
44Areflexia of lower limbs (HP:0002522)2.59339747
45Hyperkalemia (HP:0002153)2.55693192
46Pelvic girdle muscle weakness (HP:0003749)2.54678553
47Abnormality of the musculature of the pelvis (HP:0001469)2.54019623
48Abnormality of the hip-girdle musculature (HP:0001445)2.54019623
49Gastrointestinal infarctions (HP:0005244)2.53834675
50Frequent falls (HP:0002359)2.52035016
51Panhypogammaglobulinemia (HP:0003139)2.51307372
52Overlapping toe (HP:0001845)2.49965016
53Papillary thyroid carcinoma (HP:0002895)2.47497961
54Increased variability in muscle fiber diameter (HP:0003557)2.42025735
55Distal lower limb muscle weakness (HP:0009053)2.41880814
56Asymmetric septal hypertrophy (HP:0001670)2.41680625
57Abnormality of B cell number (HP:0010975)2.41497525
58B lymphocytopenia (HP:0010976)2.41497525
59Pustule (HP:0200039)2.38800975
60Recurrent bronchitis (HP:0002837)2.38503448
61Progressive muscle weakness (HP:0003323)2.37034738
62Acute myeloid leukemia (HP:0004808)2.37007216
63Tetraparesis (HP:0002273)2.35521926
64Leukocytosis (HP:0001974)2.33286158
65Distal lower limb amyotrophy (HP:0008944)2.33283751
66Bundle branch block (HP:0011710)2.32685919
67Thrombocytosis (HP:0001894)2.29393521
68Polycythemia (HP:0001901)2.29060343
69IgA deficiency (HP:0002720)2.26089546
70Abnormality of eosinophils (HP:0001879)2.25651042
71Deep philtrum (HP:0002002)2.24801465
72Increased density of long bones (HP:0006392)2.21951400
73Ulnar deviation of the wrist (HP:0003049)2.19079851
74Malignant hyperthermia (HP:0002047)2.18089036
75EMG: neuropathic changes (HP:0003445)2.18076654
76Fatigue (HP:0012378)2.17800063
77Eosinophilia (HP:0001880)2.15929767
78Volvulus (HP:0002580)2.15266245
79Dysmetric saccades (HP:0000641)2.14695548
80Arterial thrombosis (HP:0004420)2.14215818
81Hematochezia (HP:0002573)2.13273085
82Recurrent cutaneous fungal infections (HP:0011370)2.11830895
83Chronic mucocutaneous candidiasis (HP:0002728)2.11830895
84Abnormality of T cell physiology (HP:0011840)2.10253551
85Breast hypoplasia (HP:0003187)2.09839316
86Sparse lateral eyebrow (HP:0005338)2.08083265
87Irregular epiphyses (HP:0010582)2.07087313
88Autoimmune hemolytic anemia (HP:0001890)2.06278123
89Hypoplasia of the thymus (HP:0000778)2.05128440
90Mildly elevated creatine phosphokinase (HP:0008180)2.05077302
91Carpal bone hypoplasia (HP:0001498)2.04450164
92Long clavicles (HP:0000890)2.03876111
93Shoulder girdle muscle weakness (HP:0003547)2.03219055
94Autoimmune thrombocytopenia (HP:0001973)1.99594587
95Lymphoma (HP:0002665)1.98630210
96Abnormal delayed hypersensitivity skin test (HP:0002963)1.97961571
97Prominent nose (HP:0000448)1.97908261
98Lymphopenia (HP:0001888)1.97486844
99Lower limb hyperreflexia (HP:0002395)1.97388144
100Bilateral sensorineural hearing impairment (HP:0008619)1.96437252
101Round ear (HP:0100830)1.96079303
102Spontaneous hematomas (HP:0007420)1.96005149
103Basal cell carcinoma (HP:0002671)1.94857817
104Chronic diarrhea (HP:0002028)1.94204747
105Progressive external ophthalmoplegia (HP:0000590)1.89279945
106Exocrine pancreatic insufficiency (HP:0001738)1.89140029
107Capillary hemangiomas (HP:0005306)1.88930910
108Heterotopia (HP:0002282)1.88556594
109Encephalitis (HP:0002383)1.88495183
110Deep venous thrombosis (HP:0002625)1.86898099
111Cystic hygroma (HP:0000476)1.86856448
112Abnormality of cells of the lymphoid lineage (HP:0012140)1.86415612
113Limb-girdle muscle atrophy (HP:0003797)1.86284259
114Eczematoid dermatitis (HP:0000976)1.85272960
115Multiple enchondromatosis (HP:0005701)1.85252286
116Muscular dystrophy (HP:0003560)1.85207718
117Abnormality of lateral ventricle (HP:0030047)1.85084637
118Abnormality of the prostate (HP:0008775)1.83584288
119Abnormal foot bone ossification (HP:0010675)1.81304158
120Myositis (HP:0100614)1.81096321
121Osteolytic defects of the phalanges of the hand (HP:0009771)1.80262798
122Osteolytic defects of the hand bones (HP:0009699)1.80262798
123Increased CSF protein (HP:0002922)1.80237500
124Impulsivity (HP:0100710)1.80165361
125Chromsome breakage (HP:0040012)1.79669551
126Delayed puberty (HP:0000823)1.79563764
127Sandal gap (HP:0001852)1.78833576
128Chronic otitis media (HP:0000389)1.78324049
129Optic neuritis (HP:0100653)1.78268369
130Retrobulbar optic neuritis (HP:0100654)1.78268369
131Hypobetalipoproteinemia (HP:0003563)1.76688739
132Viral hepatitis (HP:0006562)1.74772284
133Peritonitis (HP:0002586)1.74763292
134Proximal amyotrophy (HP:0007126)1.74592079
135Myelodysplasia (HP:0002863)1.74545449
136Abnormality of chromosome stability (HP:0003220)1.74502490
137Persistence of primary teeth (HP:0006335)1.74035619
138Slow saccadic eye movements (HP:0000514)1.73915836
139Elevated erythrocyte sedimentation rate (HP:0003565)1.72122898
140Facial diplegia (HP:0001349)1.71671608
141Dilated cardiomyopathy (HP:0001644)1.70389482
142Broad palm (HP:0001169)1.70311218
143Abnormality of monocarboxylic acid metabolism (HP:0010996)1.70065032
144Granulocytopenia (HP:0001913)1.69869116
145Cone-rod dystrophy (HP:0000548)1.69599989
146Oligodactyly (hands) (HP:0001180)1.69592223
147Abnormality of the peritoneum (HP:0002585)1.68178378
148Absent phalangeal crease (HP:0006109)1.67607138
149Patellar aplasia (HP:0006443)1.67567638
150Hyperglycinemia (HP:0002154)1.67278583
151Thickened calvaria (HP:0002684)1.66933437
152Cortical dysplasia (HP:0002539)1.66214742
153Cellulitis (HP:0100658)1.66211542
154Long eyelashes (HP:0000527)1.66205285
155Abnormal finger flexion creases (HP:0006143)1.66102405
156Pulmonary embolism (HP:0002204)1.65963939
157Esophageal varix (HP:0002040)1.65593144
158Thyroid carcinoma (HP:0002890)1.65480993
159Verrucae (HP:0200043)1.65153537
160Papilloma (HP:0012740)1.65153537
161Cutaneous melanoma (HP:0012056)1.64339077
162Toxemia of pregnancy (HP:0100603)1.63919740
163Amaurosis fugax (HP:0100576)1.62579725
164Keratoconjunctivitis sicca (HP:0001097)1.62022247
165Truncal obesity (HP:0001956)1.61634216
166Gingival bleeding (HP:0000225)1.61279795
167Scapular winging (HP:0003691)1.60791344
168Paralysis (HP:0003470)1.60356535
169Bulbar palsy (HP:0001283)1.59844667
170Hypochromic microcytic anemia (HP:0004840)1.59471776
171Thrombophlebitis (HP:0004418)1.59252464
172Nasal polyposis (HP:0100582)1.59008080
173Sudden death (HP:0001699)1.58363302
174Generalized muscle weakness (HP:0003324)1.57019437
175Muscle stiffness (HP:0003552)1.56269798
176Neoplasm of the tracheobronchial system (HP:0100552)1.54021296
177Syringomyelia (HP:0003396)1.53620173
178Spinal cord lesions (HP:0100561)1.53620173
179Biliary tract neoplasm (HP:0100574)1.53295253
180Colitis (HP:0002583)1.51485318
181Poikilocytosis (HP:0004447)1.49468075
182Abnormality of nail color (HP:0100643)1.49359982
183Abnormality of the endocardium (HP:0004306)1.47923904
184Malnutrition (HP:0004395)1.46416589
185Hyperglycemia (HP:0003074)1.45641640
186Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.44831599
187Limb-girdle muscle weakness (HP:0003325)1.44156163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.93244738
2MAP4K13.75885980
3PRPF4B3.29052580
4EEF2K3.27735209
5PIK3CG3.10864418
6TTN2.93262604
7LATS12.62745809
8CDK122.51072121
9JAK32.47647104
10STK102.44419351
11NEK22.30060406
12TXK2.29073107
13EIF2AK32.27881000
14SIK32.18702558
15TYK22.14230630
16FGFR42.05229874
17MAP3K102.02239770
18TAOK22.02235472
19CDC72.01958771
20AKT31.97065281
21PBK1.92678770
22TRPM71.81074351
23TAOK31.80812899
24PKN21.78438349
25ITK1.70877210
26EPHA31.68608054
27BMPR21.66987395
28STK31.63005492
29TAOK11.59756436
30IRAK11.52080747
31IRAK41.51872205
32SCYL21.51818642
33MELK1.50966893
34PIM11.49503220
35SGK31.48723628
36FGFR31.47859172
37CDK41.46292112
38SGK21.46064018
39PHKG21.46016815
40PHKG11.46016815
41MAP3K81.44876543
42WEE11.42914247
43GRK61.42409266
44NLK1.41291180
45STK241.40864125
46TRIB31.39767253
47JAK11.34579176
48IKBKE1.32217784
49CDK91.26212579
50MAP3K31.23602608
51BRSK21.21567065
52MAP3K51.19206794
53ZAP701.17569475
54ERBB31.14898329
55BRD41.13180635
56RPS6KA41.09999353
57NEK91.09966930
58MAP3K11.08615159
59PLK41.07979767
60MAP2K31.05324864
61TTK1.04956848
62MAP3K141.04238626
63CHUK1.03713465
64JAK21.02973400
65PIK3CA1.02881149
66MARK31.01941898
67EPHB11.01661256
68ACVR1B1.00880368
69TNIK1.00388706
70CDK60.98901058
71STK40.96726046
72KSR10.96348085
73LATS20.96286506
74IRAK20.96193140
75RPS6KB20.94891259
76MST1R0.94325675
77TSSK60.94294902
78IRAK30.94033574
79TEC0.93949347
80MAP3K20.92700490
81YES10.90307328
82IKBKB0.90193275
83MAP3K130.89687832
84CHEK20.89310157
85MST40.86803496
86CSK0.83661717
87FLT30.82261188
88MAP3K70.81691549
89MAPK70.81631075
90DYRK1B0.81254886
91RAF10.80739529
92ERBB40.78960881
93LCK0.77919441
94BUB10.77545970
95CHEK10.77016371
96AURKB0.76562164
97MAPK120.74159787
98ALK0.73677491
99ATR0.73371642
100HCK0.72641538
101STK38L0.72299415
102PLK10.71489014
103BTK0.69428758
104MAPK110.69418703
105TGFBR20.68554636
106EPHA20.68464537
107DYRK30.68024517
108LRRK20.67419086
109BCR0.67313740
110CDK190.67007540
111MTOR0.66906286
112TYRO30.66200593
113PDGFRB0.63313511
114RPS6KA50.62723900
115WNK10.61787763
116ATM0.61763627
117PASK0.61731793
118CDK70.60895759
119NEK60.60803263
120SIK10.58096491
121TBK10.56557291
122MOS0.56432433
123SRPK10.55025578
124MAPKAPK30.53828392
125MAP3K60.52579831
126KSR20.51722061
127MET0.51613517
128PLK30.50816643
129DMPK0.50416184
130RPS6KB10.49876559
131PRKCQ0.49694755
132PRKAA10.49262158
133TRIM280.48814680
134KIT0.48582006
135CDK20.48125087
136CSF1R0.47252305
137RIPK10.46908631
138SGK4940.46246095
139SGK2230.46246095
140PDK10.46122260
141ICK0.44902170
142AKT20.44429006
143ERN10.44321845
144PRKAA20.43873323
145CSNK1G10.43547534
146HIPK20.42907063
147TGFBR10.42106810
148NME20.42014225
149ABL10.41768943
150CAMKK20.41288087
151EIF2AK10.40002963
152CAMK1D0.39570131
153MAP3K110.39316927
154CSNK1D0.39256641

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.82750009
2Vitamin B6 metabolism_Homo sapiens_hsa007502.63494629
3Cell cycle_Homo sapiens_hsa041102.26294015
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.13977299
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.00809254
6T cell receptor signaling pathway_Homo sapiens_hsa046601.97302832
7Non-homologous end-joining_Homo sapiens_hsa034501.92125160
8RNA transport_Homo sapiens_hsa030131.89937468
9Measles_Homo sapiens_hsa051621.68392847
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68126812
11Endometrial cancer_Homo sapiens_hsa052131.65129114
12p53 signaling pathway_Homo sapiens_hsa041151.60172968
13RNA degradation_Homo sapiens_hsa030181.54611419
14Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.52727939
15B cell receptor signaling pathway_Homo sapiens_hsa046621.51510592
16Herpes simplex infection_Homo sapiens_hsa051681.51338321
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.46879051
18Antigen processing and presentation_Homo sapiens_hsa046121.45530152
19Osteoclast differentiation_Homo sapiens_hsa043801.38415835
20One carbon pool by folate_Homo sapiens_hsa006701.36050594
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35671703
22Dorso-ventral axis formation_Homo sapiens_hsa043201.31437224
23Viral carcinogenesis_Homo sapiens_hsa052031.29535490
24RNA polymerase_Homo sapiens_hsa030201.28288700
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.28001690
26Insulin signaling pathway_Homo sapiens_hsa049101.26899968
27Pancreatic cancer_Homo sapiens_hsa052121.26771339
28Hepatitis B_Homo sapiens_hsa051611.23742757
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22994470
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.22637282
31Inositol phosphate metabolism_Homo sapiens_hsa005621.21392262
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20949511
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20839268
34Spliceosome_Homo sapiens_hsa030401.19920380
35mRNA surveillance pathway_Homo sapiens_hsa030151.19765123
36Chronic myeloid leukemia_Homo sapiens_hsa052201.18610220
37Autoimmune thyroid disease_Homo sapiens_hsa053201.16370402
38MicroRNAs in cancer_Homo sapiens_hsa052061.14299876
39ErbB signaling pathway_Homo sapiens_hsa040121.14252231
40Toxoplasmosis_Homo sapiens_hsa051451.12246722
41Epstein-Barr virus infection_Homo sapiens_hsa051691.11851403
42Selenocompound metabolism_Homo sapiens_hsa004501.11061214
43DNA replication_Homo sapiens_hsa030301.08926041
44Basal transcription factors_Homo sapiens_hsa030221.07942939
45Small cell lung cancer_Homo sapiens_hsa052221.06812646
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05856101
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05775739
48Glioma_Homo sapiens_hsa052141.03992510
49Leishmaniasis_Homo sapiens_hsa051401.03185540
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01631930
51Prolactin signaling pathway_Homo sapiens_hsa049171.01385028
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00930489
53TNF signaling pathway_Homo sapiens_hsa046681.00827328
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99125694
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98387760
56HTLV-I infection_Homo sapiens_hsa051660.97531116
57Nitrogen metabolism_Homo sapiens_hsa009100.97258224
58FoxO signaling pathway_Homo sapiens_hsa040680.96710814
59Base excision repair_Homo sapiens_hsa034100.95470908
60Lysine degradation_Homo sapiens_hsa003100.94745067
61Systemic lupus erythematosus_Homo sapiens_hsa053220.94717402
62Bladder cancer_Homo sapiens_hsa052190.92330497
63Hematopoietic cell lineage_Homo sapiens_hsa046400.92258657
64Staphylococcus aureus infection_Homo sapiens_hsa051500.90595901
65Caffeine metabolism_Homo sapiens_hsa002320.89291604
66Apoptosis_Homo sapiens_hsa042100.89280361
67mTOR signaling pathway_Homo sapiens_hsa041500.88493746
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88360466
69Influenza A_Homo sapiens_hsa051640.87544179
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86925583
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86884733
72Pentose phosphate pathway_Homo sapiens_hsa000300.85043893
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.83681881
74Platelet activation_Homo sapiens_hsa046110.83634194
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83145238
76Tuberculosis_Homo sapiens_hsa051520.83091354
77Asthma_Homo sapiens_hsa053100.83020113
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.83018417
79Insulin resistance_Homo sapiens_hsa049310.82870534
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82462083
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81651440
82Prostate cancer_Homo sapiens_hsa052150.81512974
83VEGF signaling pathway_Homo sapiens_hsa043700.80157739
84Colorectal cancer_Homo sapiens_hsa052100.79816492
85Acute myeloid leukemia_Homo sapiens_hsa052210.79775336
86Choline metabolism in cancer_Homo sapiens_hsa052310.79148213
87Glucagon signaling pathway_Homo sapiens_hsa049220.78634012
88Folate biosynthesis_Homo sapiens_hsa007900.75517210
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75493680
90Type II diabetes mellitus_Homo sapiens_hsa049300.75059724
91Malaria_Homo sapiens_hsa051440.74257136
92Fanconi anemia pathway_Homo sapiens_hsa034600.74223139
93HIF-1 signaling pathway_Homo sapiens_hsa040660.74193286
94Non-small cell lung cancer_Homo sapiens_hsa052230.73343037
95Viral myocarditis_Homo sapiens_hsa054160.72548534
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72069008
97Circadian rhythm_Homo sapiens_hsa047100.71513073
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71474971
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.71182568
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.70899101
101Fatty acid biosynthesis_Homo sapiens_hsa000610.69176896
102Allograft rejection_Homo sapiens_hsa053300.68303505
103Proteoglycans in cancer_Homo sapiens_hsa052050.67797528
104Renal cell carcinoma_Homo sapiens_hsa052110.67500664
105Arginine biosynthesis_Homo sapiens_hsa002200.66803345
106Focal adhesion_Homo sapiens_hsa045100.65269610
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64607337
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.64471795
109Dilated cardiomyopathy_Homo sapiens_hsa054140.64389639
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64084528
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63915616
112GnRH signaling pathway_Homo sapiens_hsa049120.63442825
113Mismatch repair_Homo sapiens_hsa034300.62686102
114Legionellosis_Homo sapiens_hsa051340.61517886
115Hepatitis C_Homo sapiens_hsa051600.60856113
116Complement and coagulation cascades_Homo sapiens_hsa046100.58596666
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58466614
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58392430
119Biosynthesis of amino acids_Homo sapiens_hsa012300.58372471
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57480344
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56854719
122TGF-beta signaling pathway_Homo sapiens_hsa043500.56768931
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.55802738
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54784652
125Homologous recombination_Homo sapiens_hsa034400.54320336
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52291195
127Thyroid cancer_Homo sapiens_hsa052160.51719426
128Chemokine signaling pathway_Homo sapiens_hsa040620.51432441
129Shigellosis_Homo sapiens_hsa051310.51396134
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.51213205
131Amoebiasis_Homo sapiens_hsa051460.51118559
132MAPK signaling pathway_Homo sapiens_hsa040100.50132386
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49351340
134Pyrimidine metabolism_Homo sapiens_hsa002400.48462409
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47097798
136AMPK signaling pathway_Homo sapiens_hsa041520.46272867
137Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46208246
138Graft-versus-host disease_Homo sapiens_hsa053320.46030607
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45023309
140Nucleotide excision repair_Homo sapiens_hsa034200.43587515
141Adherens junction_Homo sapiens_hsa045200.43103804
142Estrogen signaling pathway_Homo sapiens_hsa049150.41805272
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41630599

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