USP39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.44129960
2DNA strand elongation involved in DNA replication (GO:0006271)5.11268954
3DNA strand elongation (GO:0022616)4.84196883
4DNA replication initiation (GO:0006270)4.81255464
5telomere maintenance via semi-conservative replication (GO:0032201)4.63285126
6folic acid-containing compound biosynthetic process (GO:0009396)4.43068134
7protein localization to kinetochore (GO:0034501)4.41121884
8formation of translation preinitiation complex (GO:0001731)4.29897267
9maturation of SSU-rRNA (GO:0030490)4.29219544
10nucleobase biosynthetic process (GO:0046112)4.22068298
11viral transcription (GO:0019083)4.19097551
12DNA replication-dependent nucleosome assembly (GO:0006335)4.17244651
13DNA replication-dependent nucleosome organization (GO:0034723)4.17244651
14translational termination (GO:0006415)4.13689780
15mitotic nuclear envelope disassembly (GO:0007077)4.12275919
16telomere maintenance via recombination (GO:0000722)4.08195217
17pore complex assembly (GO:0046931)3.99886105
18ribosomal small subunit assembly (GO:0000028)3.99202136
19mitotic recombination (GO:0006312)3.92247533
20DNA replication checkpoint (GO:0000076)3.87678297
21nuclear pore organization (GO:0006999)3.87442725
22IMP biosynthetic process (GO:0006188)3.87234495
23purine nucleobase biosynthetic process (GO:0009113)3.86768662
24DNA topological change (GO:0006265)3.84776596
25translational elongation (GO:0006414)3.83411877
26membrane disassembly (GO:0030397)3.83340136
27nuclear envelope disassembly (GO:0051081)3.83340136
28protein localization to chromosome, centromeric region (GO:0071459)3.79684401
29DNA deamination (GO:0045006)3.78561556
30translational initiation (GO:0006413)3.77830619
31mitotic metaphase plate congression (GO:0007080)3.77185346
32ribosomal large subunit biogenesis (GO:0042273)3.69299074
33nuclear pore complex assembly (GO:0051292)3.63528572
34telomere maintenance via telomere lengthening (GO:0010833)3.61501550
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.59560788
36ribosome assembly (GO:0042255)3.59248624
37nucleotide-excision repair, DNA gap filling (GO:0006297)3.58923832
38establishment of viral latency (GO:0019043)3.57425662
39chromatin remodeling at centromere (GO:0031055)3.55481668
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.54342061
41CENP-A containing nucleosome assembly (GO:0034080)3.53473510
42DNA ligation (GO:0006266)3.52303062
43IMP metabolic process (GO:0046040)3.50350638
44ribosome biogenesis (GO:0042254)3.49068117
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.49022766
46mitotic sister chromatid segregation (GO:0000070)3.48101140
47ribonucleoprotein complex biogenesis (GO:0022613)3.47099628
48mitotic chromosome condensation (GO:0007076)3.44867455
49ribosomal small subunit biogenesis (GO:0042274)3.44380029
50peptidyl-arginine omega-N-methylation (GO:0035247)3.41036377
51SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40764160
52DNA replication-independent nucleosome assembly (GO:0006336)3.37839904
53DNA replication-independent nucleosome organization (GO:0034724)3.37839904
54viral mRNA export from host cell nucleus (GO:0046784)3.34269274
55DNA duplex unwinding (GO:0032508)3.32802129
56protein targeting to ER (GO:0045047)3.30913797
57cotranslational protein targeting to membrane (GO:0006613)3.30366539
58DNA geometric change (GO:0032392)3.30350433
59negative regulation of mRNA processing (GO:0050686)3.30050968
60spliceosomal snRNP assembly (GO:0000387)3.29254933
61metaphase plate congression (GO:0051310)3.28557279
62cellular protein complex disassembly (GO:0043624)3.27976153
63establishment of integrated proviral latency (GO:0075713)3.25873578
64negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.25841510
65sister chromatid segregation (GO:0000819)3.24276373
66viral life cycle (GO:0019058)3.23606709
67rRNA processing (GO:0006364)3.23436204
68negative regulation of ligase activity (GO:0051352)3.23429962
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.23429962
70tRNA aminoacylation for protein translation (GO:0006418)3.22921512
71regulation of spindle organization (GO:0090224)3.22210494
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.22038069
73non-recombinational repair (GO:0000726)3.21608968
74double-strand break repair via nonhomologous end joining (GO:0006303)3.21608968
75proteasome assembly (GO:0043248)3.17599699
76mitotic sister chromatid cohesion (GO:0007064)3.15468668
77positive regulation of chromosome segregation (GO:0051984)3.15020194
78amino acid activation (GO:0043038)3.13942903
79tRNA aminoacylation (GO:0043039)3.13942903
80establishment of protein localization to endoplasmic reticulum (GO:0072599)3.13847271
81rRNA metabolic process (GO:0016072)3.13106669
82deoxyribonucleotide biosynthetic process (GO:0009263)3.11711909
83protein localization to endoplasmic reticulum (GO:0070972)3.08779406
84pseudouridine synthesis (GO:0001522)3.08310201
85regulation of mitotic spindle organization (GO:0060236)3.07760304
86regulation of translational termination (GO:0006449)3.07705153
87nuclear envelope organization (GO:0006998)3.06614686
88base-excision repair (GO:0006284)3.06414566
89protein complex disassembly (GO:0043241)3.05077269
90chromatin assembly or disassembly (GO:0006333)3.04297130
91negative regulation of RNA splicing (GO:0033119)3.03641459
92negative regulation of mRNA metabolic process (GO:1903312)3.02135627
93DNA conformation change (GO:0071103)3.01946551
94establishment of chromosome localization (GO:0051303)3.01752055
95nucleobase-containing small molecule interconversion (GO:0015949)3.01507915
96histone exchange (GO:0043486)3.00704774
97chromosome condensation (GO:0030261)2.99835637
98kinetochore organization (GO:0051383)2.99804280
99histone arginine methylation (GO:0034969)2.99667159
100Golgi transport vesicle coating (GO:0048200)2.98781365
101COPI coating of Golgi vesicle (GO:0048205)2.98781365
102proline biosynthetic process (GO:0006561)2.98235257
103anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97548742
104chromosome segregation (GO:0007059)2.97519846
105spliceosomal tri-snRNP complex assembly (GO:0000244)2.96518559
106negative regulation of chromosome segregation (GO:0051985)2.96443765
107translesion synthesis (GO:0019985)2.96360774
108deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96003704
109regulation of chromosome segregation (GO:0051983)2.95083374
110positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94106897
111regulation of histone H3-K9 methylation (GO:0051570)2.93899747
112folic acid metabolic process (GO:0046655)2.92952325
113attachment of spindle microtubules to kinetochore (GO:0008608)2.92380552
114nuclear-transcribed mRNA catabolic process (GO:0000956)2.92266959
115mitotic spindle checkpoint (GO:0071174)2.91684977
116negative regulation of sister chromatid segregation (GO:0033046)2.90844247
117negative regulation of mitotic sister chromatid separation (GO:2000816)2.90844247
118negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90844247
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90844247
120spindle checkpoint (GO:0031577)2.89885906
121negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89008334
122peptidyl-arginine N-methylation (GO:0035246)2.88510052
123peptidyl-arginine methylation (GO:0018216)2.88510052
124RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.88372416
125mRNA splicing, via spliceosome (GO:0000398)2.88372416
126regulation of centriole replication (GO:0046599)2.87913257
127regulation of translational fidelity (GO:0006450)2.87577468
128macromolecular complex disassembly (GO:0032984)2.87244599
129RNA splicing, via transesterification reactions (GO:0000375)2.87185327
130regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.86559188
131spindle assembly checkpoint (GO:0071173)2.86490815
132mitotic spindle assembly checkpoint (GO:0007094)2.86194778
133somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83909134
134somatic hypermutation of immunoglobulin genes (GO:0016446)2.83909134
135negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81776663
136G1/S transition of mitotic cell cycle (GO:0000082)2.81571383
137cell cycle G1/S phase transition (GO:0044843)2.81571383

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.54744425
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.22164511
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.18009376
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.11168157
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56055721
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.01667037
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.95164825
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72026242
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71746145
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.60660043
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58275225
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.56936374
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.49090285
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37394874
15XRN2_22483619_ChIP-Seq_HELA_Human2.35892663
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35197870
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26904970
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.25033848
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18622595
20AR_21909140_ChIP-Seq_LNCAP_Human2.16654644
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12108519
22MYC_22102868_ChIP-Seq_BL_Human2.03833085
23VDR_23849224_ChIP-Seq_CD4+_Human2.01680712
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97737950
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.93525067
26E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90078713
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85448849
28DCP1A_22483619_ChIP-Seq_HELA_Human1.84204150
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82230922
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78876159
31* FOXP3_21729870_ChIP-Seq_TREG_Human1.77731183
32* GABP_19822575_ChIP-Seq_HepG2_Human1.76656923
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75913210
34TTF2_22483619_ChIP-Seq_HELA_Human1.72764182
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71130060
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71041479
37* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69853217
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65010439
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64487651
40CIITA_25753668_ChIP-Seq_RAJI_Human1.64098141
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61249879
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60342823
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48824663
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48309680
45KDM5A_27292631_Chip-Seq_BREAST_Human1.44121184
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39341407
47* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38429343
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38291232
49VDR_21846776_ChIP-Seq_THP-1_Human1.38228948
50ELK1_19687146_ChIP-ChIP_HELA_Human1.37217253
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36483926
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35533980
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33516003
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33180966
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32737963
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32627213
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30984830
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30088380
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28957883
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27234900
61TFEB_21752829_ChIP-Seq_HELA_Human1.24359710
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23842695
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.22959176
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19915822
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19114385
66* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14966679
67* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12787576
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11402382
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07887707
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05637431
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05295547
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05077176
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04402642
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04078829
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03186174
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02721543
77* SRF_21415370_ChIP-Seq_HL-1_Mouse1.02147702
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01393177
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01368122
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00584303
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00365050
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99374015
83NOTCH1_21737748_ChIP-Seq_TLL_Human0.98725093
84ZNF263_19887448_ChIP-Seq_K562_Human0.95112181
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95014176
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94466008
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94363622
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.92271318
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90168055
90* SPI1_23547873_ChIP-Seq_NB4_Human0.89892950
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89812933
92MYC_18940864_ChIP-ChIP_HL60_Human0.89113499
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88044796
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.87669512
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87304351
96NANOG_21062744_ChIP-ChIP_HESCs_Human0.85637038
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85355670
98NCOR1_26117541_ChIP-Seq_K562_Human0.84414961
99UTX_26944678_Chip-Seq_JUKART_Human0.83194258
100CHD1_26751641_Chip-Seq_LNCaP_Human0.82575043
101ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81958403
102TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81117442
103TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80405780
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.79945483
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78939293
106MAF_26560356_Chip-Seq_TH1_Human0.78602638
107* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78595046
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.78255416
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78106149
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.77645273
111* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.77497333
112TP63_19390658_ChIP-ChIP_HaCaT_Human0.76477698
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75680570
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74464721

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.93957749
2MP0010094_abnormal_chromosome_stability4.53470290
3MP0004957_abnormal_blastocyst_morpholog4.44232240
4MP0003111_abnormal_nucleus_morphology4.40960110
5MP0003077_abnormal_cell_cycle4.03496850
6MP0008057_abnormal_DNA_replication3.48534528
7MP0008007_abnormal_cellular_replicative2.73694282
8MP0008058_abnormal_DNA_repair2.73542057
9MP0008932_abnormal_embryonic_tissue2.64026188
10MP0001730_embryonic_growth_arrest2.63897579
11MP0010352_gastrointestinal_tract_polyps2.53809834
12MP0000350_abnormal_cell_proliferation2.43241814
13MP0002396_abnormal_hematopoietic_system2.42507934
14MP0009697_abnormal_copulation2.40020062
15MP0003123_paternal_imprinting2.21008683
16MP0010307_abnormal_tumor_latency2.13013229
17MP0000490_abnormal_crypts_of1.98635815
18MP0001697_abnormal_embryo_size1.86896283
19MP0005380_embryogenesis_phenotype1.78212996
20MP0001672_abnormal_embryogenesis/_devel1.78212996
21MP0002080_prenatal_lethality1.76957073
22MP0003806_abnormal_nucleotide_metabolis1.74207917
23MP0004808_abnormal_hematopoietic_stem1.72403504
24MP0006054_spinal_hemorrhage1.71878092
25MP0003984_embryonic_growth_retardation1.65749355
26MP0006035_abnormal_mitochondrial_morpho1.65317951
27MP0005451_abnormal_body_composition1.63816699
28MP0002085_abnormal_embryonic_tissue1.62169050
29MP0002088_abnormal_embryonic_growth/wei1.61181756
30MP0002019_abnormal_tumor_incidence1.57840064
31MP0002084_abnormal_developmental_patter1.55738441
32MP0000313_abnormal_cell_death1.53906245
33MP0002877_abnormal_melanocyte_morpholog1.53425983
34MP0008260_abnormal_autophagy1.50166067
35MP0003786_premature_aging1.50132660
36MP0009333_abnormal_splenocyte_physiolog1.49759612
37MP0002086_abnormal_extraembryonic_tissu1.49290114
38MP0005076_abnormal_cell_differentiation1.48562978
39MP0004233_abnormal_muscle_weight1.47649885
40MP0004197_abnormal_fetal_growth/weight/1.47251704
41MP0001545_abnormal_hematopoietic_system1.45598090
42MP0005397_hematopoietic_system_phenotyp1.45598090
43MP0001661_extended_life_span1.43563354
44MP0010030_abnormal_orbit_morphology1.35802385
45MP0003763_abnormal_thymus_physiology1.33085938
46MP0004185_abnormal_adipocyte_glucose1.30591660
47MP0002398_abnormal_bone_marrow1.29924351
48MP0008995_early_reproductive_senescence1.27129328
49MP0000703_abnormal_thymus_morphology1.27005624
50MP0003705_abnormal_hypodermis_morpholog1.26108239
51MP0003567_abnormal_fetal_cardiomyocyte1.25635119
52MP0000537_abnormal_urethra_morphology1.24853333
53MP0002722_abnormal_immune_system1.22501938
54MP0000689_abnormal_spleen_morphology1.18880302
55MP0008877_abnormal_DNA_methylation1.17933958
56MP0003718_maternal_effect1.17071142
57MP0004147_increased_porphyrin_level1.16171628
58MP0001293_anophthalmia1.16061204
59MP0006036_abnormal_mitochondrial_physio1.09491789
60MP0005023_abnormal_wound_healing1.08086082
61MP0003656_abnormal_erythrocyte_physiolo1.05951758
62MP0009053_abnormal_anal_canal1.05229196
63MP0006292_abnormal_olfactory_placode1.04973920
64MP0000372_irregular_coat_pigmentation1.04199994
65MP0002429_abnormal_blood_cell1.00578628
66MP0000358_abnormal_cell_content/1.00319663
67MP0005083_abnormal_biliary_tract1.00204415
68MP0000858_altered_metastatic_potential0.96237164
69MP0001727_abnormal_embryo_implantation0.95897895
70MP0009278_abnormal_bone_marrow0.94627720
71MP0002210_abnormal_sex_determination0.93911744
72MP0003890_abnormal_embryonic-extraembry0.93371888
73MP0004264_abnormal_extraembryonic_tissu0.89092679
74MP0000685_abnormal_immune_system0.88570931
75MP0001145_abnormal_male_reproductive0.88526939
76MP0003119_abnormal_digestive_system0.87861399
77MP0008789_abnormal_olfactory_epithelium0.87545061
78MP0003566_abnormal_cell_adhesion0.86770071
79MP0003221_abnormal_cardiomyocyte_apopto0.86523689
80MP0001915_intracranial_hemorrhage0.85752239
81MP0005621_abnormal_cell_physiology0.84625923
82MP0005384_cellular_phenotype0.84265896
83MP0000477_abnormal_intestine_morphology0.82680863
84MP0000716_abnormal_immune_system0.82491184
85MP0002132_abnormal_respiratory_system0.82195693
86MP0003121_genomic_imprinting0.80659376
87MP0005464_abnormal_platelet_physiology0.80357366
88MP0002111_abnormal_tail_morphology0.79820326
89MP0001929_abnormal_gametogenesis0.77778429
90MP0003186_abnormal_redox_activity0.77013815
91MP0002092_abnormal_eye_morphology0.74545189
92MP0009672_abnormal_birth_weight0.74269094
93MP0002269_muscular_atrophy0.72738031
94MP0001853_heart_inflammation0.71580974
95MP0000653_abnormal_sex_gland0.70169294
96MP0004133_heterotaxia0.69928741
97MP0000428_abnormal_craniofacial_morphol0.69721483
98MP0002697_abnormal_eye_size0.68766772
99MP0008770_decreased_survivor_rate0.68526581
100MP0001800_abnormal_humoral_immune0.66994871
101MP0002405_respiratory_system_inflammati0.66327923
102MP0009703_decreased_birth_body0.66119161
103MP0005075_abnormal_melanosome_morpholog0.65592325
104MP0000733_abnormal_muscle_development0.65489386
105MP0002796_impaired_skin_barrier0.65107579
106MP0000678_abnormal_parathyroid_gland0.64530119
107MP0003315_abnormal_perineum_morphology0.63809555
108MP0001529_abnormal_vocalization0.63065909
109MP0005394_taste/olfaction_phenotype0.62235087
110MP0005499_abnormal_olfactory_system0.62235087
111MP0002095_abnormal_skin_pigmentation0.60388061
112MP0005058_abnormal_lysosome_morphology0.60343890
113MP0001881_abnormal_mammary_gland0.60171228
114MP0005330_cardiomyopathy0.60094508
115MP0000598_abnormal_liver_morphology0.59912772
116MP0001849_ear_inflammation0.59631794
117MP0002009_preneoplasia0.58994269
118MP0002420_abnormal_adaptive_immunity0.58961273
119MP0002653_abnormal_ependyma_morphology0.58572829
120MP0003385_abnormal_body_wall0.57615389
121MP0001286_abnormal_eye_development0.57565838
122MP0001819_abnormal_immune_cell0.57173268
123MP0003941_abnormal_skin_development0.56789192
124MP0009379_abnormal_foot_pigmentation0.55967218
125MP0002160_abnormal_reproductive_system0.55626129
126MP0002452_abnormal_antigen_presenting0.55124367
127MP0000465_gastrointestinal_hemorrhage0.54278251
128MP0005389_reproductive_system_phenotype0.53974152
129MP0003937_abnormal_limbs/digits/tail_de0.53781832
130MP0005501_abnormal_skin_physiology0.52974131
131MP0002075_abnormal_coat/hair_pigmentati0.52828558
132MP0001119_abnormal_female_reproductive0.52561416

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.71505640
2Abnormal number of erythroid precursors (HP:0012131)4.47670830
3Reticulocytopenia (HP:0001896)4.38535819
4Birth length less than 3rd percentile (HP:0003561)4.33174146
5Selective tooth agenesis (HP:0001592)3.75533204
6Oral leukoplakia (HP:0002745)3.75356391
7Abnormality of glycolysis (HP:0004366)3.66064609
8Colon cancer (HP:0003003)3.48280969
9Breast hypoplasia (HP:0003187)3.46070442
10Ependymoma (HP:0002888)3.42702671
11Cholecystitis (HP:0001082)3.37704940
12Abnormal gallbladder physiology (HP:0012438)3.37704940
13Increased serum pyruvate (HP:0003542)3.32573161
14Microvesicular hepatic steatosis (HP:0001414)3.21614884
15Cortical dysplasia (HP:0002539)3.06353730
16Macrocytic anemia (HP:0001972)3.04842417
17Abnormality of the anterior horn cell (HP:0006802)3.04838297
18Degeneration of anterior horn cells (HP:0002398)3.04838297
19Pallor (HP:0000980)3.01078883
20Aplastic anemia (HP:0001915)2.98573285
21Medulloblastoma (HP:0002885)2.93774331
22Agnosia (HP:0010524)2.88789820
23Ragged-red muscle fibers (HP:0003200)2.85397771
24Patellar aplasia (HP:0006443)2.79466089
25Basal cell carcinoma (HP:0002671)2.78968178
26Rough bone trabeculation (HP:0100670)2.78898101
2711 pairs of ribs (HP:0000878)2.78827511
28Abnormality of chromosome stability (HP:0003220)2.78123262
29Cerebral hypomyelination (HP:0006808)2.74222163
30Multiple enchondromatosis (HP:0005701)2.71777206
31Rhabdomyosarcoma (HP:0002859)2.66955052
32Absent thumb (HP:0009777)2.66137780
33Microglossia (HP:0000171)2.62889712
34Aplasia/Hypoplasia of the patella (HP:0006498)2.62372343
35Thrombocytosis (HP:0001894)2.59200852
36Carpal bone hypoplasia (HP:0001498)2.58262557
37Neoplasm of the pancreas (HP:0002894)2.57819198
38Meckel diverticulum (HP:0002245)2.57489825
39Chromsome breakage (HP:0040012)2.55096864
40Trismus (HP:0000211)2.52984495
41Abnormality of the ileum (HP:0001549)2.50663993
42Myelodysplasia (HP:0002863)2.47460151
43Nephroblastoma (Wilms tumor) (HP:0002667)2.46464214
44Abnormality of reticulocytes (HP:0004312)2.45420190
45Abnormality of the heme biosynthetic pathway (HP:0010472)2.45225677
46Microretrognathia (HP:0000308)2.42443855
47Abnormality of the preputium (HP:0100587)2.41619491
48Squamous cell carcinoma (HP:0002860)2.40976056
49Premature graying of hair (HP:0002216)2.38842622
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37764332
51Abnormal number of incisors (HP:0011064)2.36612907
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.35054898
53Proximal placement of thumb (HP:0009623)2.28487686
54Abnormality of the calcaneus (HP:0008364)2.26762999
55Missing ribs (HP:0000921)2.26337680
56Embryonal renal neoplasm (HP:0011794)2.25355660
57Absent radius (HP:0003974)2.24966181
58Abnormal lung lobation (HP:0002101)2.24078893
59Duodenal stenosis (HP:0100867)2.22243476
60Small intestinal stenosis (HP:0012848)2.22243476
61Abnormality of the umbilical cord (HP:0010881)2.21961835
62Increased nuchal translucency (HP:0010880)2.21199912
63Deviation of the thumb (HP:0009603)2.19716854
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17607369
65Bone marrow hypocellularity (HP:0005528)2.14950842
66Atrophy/Degeneration involving motor neurons (HP:0007373)2.14910094
67Entropion (HP:0000621)2.14888435
68Atresia of the external auditory canal (HP:0000413)2.14882749
69Reticulocytosis (HP:0001923)2.14280319
70Progressive muscle weakness (HP:0003323)2.13966314
71Progressive external ophthalmoplegia (HP:0000590)2.13274474
72Glossoptosis (HP:0000162)2.10771535
73Amaurosis fugax (HP:0100576)2.09674878
74Impulsivity (HP:0100710)2.09478444
75Combined immunodeficiency (HP:0005387)2.08129691
76Astrocytoma (HP:0009592)2.06549400
77Abnormality of the astrocytes (HP:0100707)2.06549400
78Cholelithiasis (HP:0001081)2.06320361
79Increased serum lactate (HP:0002151)2.06148555
80Personality changes (HP:0000751)2.05809740
81Aplasia involving forearm bones (HP:0009822)2.05086487
82Absent forearm bone (HP:0003953)2.05086487
83Cellular immunodeficiency (HP:0005374)2.04932822
84Type I transferrin isoform profile (HP:0003642)2.04722173
85Prominent nose (HP:0000448)2.03063782
86Secondary amenorrhea (HP:0000869)2.02232593
87Spastic diplegia (HP:0001264)2.02016476
88Lymphoma (HP:0002665)2.01916214
89Horseshoe kidney (HP:0000085)2.01711893
90Tracheoesophageal fistula (HP:0002575)2.01428207
91Neoplasm of striated muscle (HP:0009728)2.00548764
92Cafe-au-lait spot (HP:0000957)2.00496034
93High pitched voice (HP:0001620)1.98873472
94IgM deficiency (HP:0002850)1.93806957
95Choanal atresia (HP:0000453)1.93548474
96High anterior hairline (HP:0009890)1.93443199
97Premature ovarian failure (HP:0008209)1.93080733
98Abnormality of the duodenum (HP:0002246)1.91810161
99Sloping forehead (HP:0000340)1.91282716
100Adenoma sebaceum (HP:0009720)1.89733696
101Angiofibromas (HP:0010615)1.89733696
102Abnormal trabecular bone morphology (HP:0100671)1.88296067
103Facial cleft (HP:0002006)1.86533409
104Increased density of long bones (HP:0006392)1.85491714
105Slender long bone (HP:0003100)1.83768852
106Glioma (HP:0009733)1.83550433
107Abnormality of the labia minora (HP:0012880)1.82672250
108Abnormal umbilical cord blood vessels (HP:0011403)1.81998073
109Single umbilical artery (HP:0001195)1.81998073
110Abnormality of the fetal cardiovascular system (HP:0010948)1.81998073
111Triphalangeal thumb (HP:0001199)1.81791278
112Cutaneous melanoma (HP:0012056)1.80585852
113Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.80329874
114Decreased activity of mitochondrial respiratory chain (HP:0008972)1.80329874
115Orthostatic hypotension (HP:0001278)1.79823997
116Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77689416
117Neoplasm of the colon (HP:0100273)1.77466742
118Abnormal gallbladder morphology (HP:0012437)1.77401935
119Ectopic kidney (HP:0000086)1.76639637
120Overlapping toe (HP:0001845)1.76459568
121Pelvic girdle muscle weakness (HP:0003749)1.75752512
122Rhabdomyolysis (HP:0003201)1.75671904
123Severe combined immunodeficiency (HP:0004430)1.75053069
124Hypergonadotropic hypogonadism (HP:0000815)1.73871767
125Calcaneovalgus deformity (HP:0001848)1.73480584
126Abnormality of pyrimidine metabolism (HP:0004353)1.73184969
127Abnormality of the carotid arteries (HP:0005344)1.71877492
128Abnormality of cochlea (HP:0000375)1.71550008
129Poikiloderma (HP:0001029)1.70553742
130Abnormalities of placenta or umbilical cord (HP:0001194)1.70536253
131Hyperacusis (HP:0010780)1.70197163
132Biliary tract neoplasm (HP:0100574)1.69949700
133Postnatal microcephaly (HP:0005484)1.69735105
134Pancytopenia (HP:0001876)1.69393764
135Ankle contracture (HP:0006466)1.69063764
136Neoplasm of the oral cavity (HP:0100649)1.69005886
137Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.68936384
138Lactic acidosis (HP:0003128)1.68588582
139Abnormal protein glycosylation (HP:0012346)1.68457205
140Abnormal glycosylation (HP:0012345)1.68457205
141Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.68457205
142Abnormal protein N-linked glycosylation (HP:0012347)1.68457205
143Aplasia/Hypoplasia of the thymus (HP:0010515)1.67043308
144Absent epiphyses (HP:0010577)1.66921865
145Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.66921865
146Insomnia (HP:0100785)1.66678226
147Hyperalaninemia (HP:0003348)1.66281782
148Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66281782
149Abnormality of alanine metabolism (HP:0010916)1.66281782
150Upper limb muscle weakness (HP:0003484)1.64407968
151Short thumb (HP:0009778)1.63445751
152Myoglobinuria (HP:0002913)1.62642736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.43725618
2WEE14.13087020
3CDC73.86931906
4PBK3.22105006
5EIF2AK13.03120668
6VRK22.80680402
7NEK22.72119535
8EEF2K2.42393233
9NME22.40663174
10TESK22.25528146
11TLK12.19947811
12ACVR1B2.15013290
13SMG12.04398431
14TTK2.03482798
15RPS6KA42.00419818
16SCYL21.98599460
17SRPK11.94466426
18RPS6KB21.92172762
19NEK11.91041706
20TRIM281.86649119
21BRSK21.81530947
22DYRK31.78087186
23STK101.77800715
24PKN21.77596352
25MAP3K81.74337823
26PLK11.73127130
27TSSK61.72298855
28MAP3K101.69016089
29SIK31.59411843
30CDK71.56241739
31AURKB1.54417489
32ZAK1.53127378
33MST41.46122977
34PASK1.46095702
35EIF2AK31.43908606
36BRSK11.43558984
37ATR1.43489278
38VRK11.42286119
39CDK41.41642898
40STK161.40708638
41TGFBR11.39440362
42CDK121.38856479
43LRRK21.34190382
44PAK41.32878516
45AURKA1.29710884
46CDK81.26504614
47TRIB31.19968315
48PLK41.17639140
49TESK11.14926609
50CHEK21.14851952
51EPHA21.14317332
52NME11.14255861
53MAP4K11.12403229
54MKNK11.11572558
55CHEK11.11462899
56PLK31.05747713
57MAPKAPK31.05067289
58KDR1.04705607
59MAP3K111.04041696
60FLT31.01797794
61STK40.98392275
62DAPK10.97289291
63IRAK30.97264144
64BCR0.92534156
65PIM20.90940178
66EIF2AK20.87116966
67ICK0.86779477
68PDK20.83865353
69MAP2K30.82846139
70PIM10.82368372
71CSNK1G30.80485340
72CCNB10.79362739
73CDK20.76925971
74BMX0.76631234
75PAK10.75413139
76GRK60.73906100
77ALK0.71188091
78MELK0.71168353
79ATM0.67767734
80CDK90.66114975
81CDK60.65511097
82TAOK20.65107159
83MST1R0.63202188
84CSNK1A1L0.61680002
85CSNK2A20.60632463
86BCKDK0.60433044
87LATS20.56416630
88CSNK1G10.53974335
89ZAP700.51146314
90MTOR0.50414922
91RAF10.50038192
92PAK20.49817610
93NUAK10.49622667
94STK30.49493249
95CSNK2A10.49482989
96CDK10.48986751
97RPS6KA50.48919443
98ILK0.48756673
99BTK0.46914701
100BRD40.46106623
101ERBB40.45979422
102CDK140.44923392
103BLK0.43204665
104ERBB30.42922135
105MKNK20.42654897
106CDK180.42083127
107CDK190.41578869
108TAF10.40576317
109LIMK10.40199434
110AKT20.40157104
111TTN0.39361166
112MAPK110.39311675
113ERN10.39234729
114JAK30.38094428
115FGFR10.37296111
116CDK150.35459043
117MAP3K30.34763033
118MET0.32485680
119BRAF0.32199695
120TAOK10.31619583
121KSR20.31109220
122ARAF0.31001572
123MAP3K50.30542228
124CSF1R0.29217493
125PRKCI0.27593518
126KIT0.27120242
127CSNK1E0.26520753
128CDK11A0.24224233
129MAPKAPK20.24128458
130TYK20.23776796
131CLK10.23353774
132PRKDC0.20332886

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.26865961
2Mismatch repair_Homo sapiens_hsa034304.22801736
3Ribosome_Homo sapiens_hsa030103.52813954
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42111323
5* Spliceosome_Homo sapiens_hsa030403.32014502
6RNA transport_Homo sapiens_hsa030133.11627149
7Base excision repair_Homo sapiens_hsa034103.08651277
8Proteasome_Homo sapiens_hsa030503.08040966
9Nucleotide excision repair_Homo sapiens_hsa034202.79041417
10One carbon pool by folate_Homo sapiens_hsa006702.78212267
11Cell cycle_Homo sapiens_hsa041102.76582798
12Homologous recombination_Homo sapiens_hsa034402.76388194
13RNA polymerase_Homo sapiens_hsa030202.68824026
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.53915233
15Pyrimidine metabolism_Homo sapiens_hsa002402.30429189
16Fanconi anemia pathway_Homo sapiens_hsa034601.90727397
17Non-homologous end-joining_Homo sapiens_hsa034501.79593282
18p53 signaling pathway_Homo sapiens_hsa041151.65598019
19RNA degradation_Homo sapiens_hsa030181.65088252
20Systemic lupus erythematosus_Homo sapiens_hsa053221.63308697
21mRNA surveillance pathway_Homo sapiens_hsa030151.59934538
22Basal transcription factors_Homo sapiens_hsa030221.33020519
23Fatty acid elongation_Homo sapiens_hsa000621.22581240
24Epstein-Barr virus infection_Homo sapiens_hsa051691.21267267
25Biosynthesis of amino acids_Homo sapiens_hsa012301.18872071
26Viral carcinogenesis_Homo sapiens_hsa052031.15877859
27Pentose phosphate pathway_Homo sapiens_hsa000301.15593050
28Antigen processing and presentation_Homo sapiens_hsa046121.12708764
29Purine metabolism_Homo sapiens_hsa002301.09298684
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.03059052
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02436398
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.01091151
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94281518
34Selenocompound metabolism_Homo sapiens_hsa004500.93817822
35Sulfur relay system_Homo sapiens_hsa041220.92724810
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91925494
37Oocyte meiosis_Homo sapiens_hsa041140.91924505
38Herpes simplex infection_Homo sapiens_hsa051680.89035919
39HTLV-I infection_Homo sapiens_hsa051660.83601241
40Steroid biosynthesis_Homo sapiens_hsa001000.83013783
41Thyroid cancer_Homo sapiens_hsa052160.79909953
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.79420079
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75044274
44Folate biosynthesis_Homo sapiens_hsa007900.75039264
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72920480
46Carbon metabolism_Homo sapiens_hsa012000.70083853
47MicroRNAs in cancer_Homo sapiens_hsa052060.68421365
48Parkinsons disease_Homo sapiens_hsa050120.66711238
49Small cell lung cancer_Homo sapiens_hsa052220.65554076
50Primary immunodeficiency_Homo sapiens_hsa053400.65052128
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64502652
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63639213
53Alcoholism_Homo sapiens_hsa050340.63186583
54Propanoate metabolism_Homo sapiens_hsa006400.59601649
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58378912
56Vitamin B6 metabolism_Homo sapiens_hsa007500.58260526
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57548785
58Bladder cancer_Homo sapiens_hsa052190.57474536
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57422336
60Apoptosis_Homo sapiens_hsa042100.57011702
61Chronic myeloid leukemia_Homo sapiens_hsa052200.56924031
62Colorectal cancer_Homo sapiens_hsa052100.56261457
63Shigellosis_Homo sapiens_hsa051310.55079661
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53184881
65Legionellosis_Homo sapiens_hsa051340.52889323
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.49576808
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48750789
68Lysine degradation_Homo sapiens_hsa003100.48577193
69Glutathione metabolism_Homo sapiens_hsa004800.47055142
70N-Glycan biosynthesis_Homo sapiens_hsa005100.46860365
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46579768
72Hepatitis B_Homo sapiens_hsa051610.46272177
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43987864
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40089061
75Acute myeloid leukemia_Homo sapiens_hsa052210.39716970
76Hippo signaling pathway_Homo sapiens_hsa043900.39128711
77Metabolic pathways_Homo sapiens_hsa011000.37844953
78Measles_Homo sapiens_hsa051620.36530653
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35578645
80Oxidative phosphorylation_Homo sapiens_hsa001900.34954545
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34587258
82TGF-beta signaling pathway_Homo sapiens_hsa043500.34197190
83Notch signaling pathway_Homo sapiens_hsa043300.33893194
84Fatty acid metabolism_Homo sapiens_hsa012120.33797747
85Prostate cancer_Homo sapiens_hsa052150.30641189
86Viral myocarditis_Homo sapiens_hsa054160.30220655
87Fructose and mannose metabolism_Homo sapiens_hsa000510.29548926
88Basal cell carcinoma_Homo sapiens_hsa052170.29533287
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29415600
90HIF-1 signaling pathway_Homo sapiens_hsa040660.29411505
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29290027
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29204736
93Protein export_Homo sapiens_hsa030600.27585765
94B cell receptor signaling pathway_Homo sapiens_hsa046620.27277899
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26448992
96mTOR signaling pathway_Homo sapiens_hsa041500.25458849
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.24420925
98Pancreatic cancer_Homo sapiens_hsa052120.24346153
99Hematopoietic cell lineage_Homo sapiens_hsa046400.22906355
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22594032
101Pathways in cancer_Homo sapiens_hsa052000.21854285
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21390464
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20507356
104Non-small cell lung cancer_Homo sapiens_hsa052230.18953715
105Arginine biosynthesis_Homo sapiens_hsa002200.18518847
106Adherens junction_Homo sapiens_hsa045200.17760234
107Influenza A_Homo sapiens_hsa051640.16851478
108Caffeine metabolism_Homo sapiens_hsa002320.16228061
109Proteoglycans in cancer_Homo sapiens_hsa052050.14711896
110Endometrial cancer_Homo sapiens_hsa052130.13897182
111Arginine and proline metabolism_Homo sapiens_hsa003300.12379666
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12258926
113Galactose metabolism_Homo sapiens_hsa000520.11713323
114Pyruvate metabolism_Homo sapiens_hsa006200.11576117
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11237333
116Vibrio cholerae infection_Homo sapiens_hsa051100.11094635
117T cell receptor signaling pathway_Homo sapiens_hsa046600.10810583
118Huntingtons disease_Homo sapiens_hsa050160.10739447
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10631798

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