USP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activated T cell proliferation (GO:0050798)5.33671686
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.02471418
3negative regulation of cell killing (GO:0031342)5.02471418
4alpha-linolenic acid metabolic process (GO:0036109)4.53652912
5regulation of B cell receptor signaling pathway (GO:0050855)4.46628237
6fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.28065831
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.19673657
8regulation of gamma-delta T cell activation (GO:0046643)3.94968423
9positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.88144593
10mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.88144593
11cellular response to interleukin-15 (GO:0071350)3.87261720
12kynurenine metabolic process (GO:0070189)3.82144431
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.81329104
14negative regulation of fibrinolysis (GO:0051918)3.74810960
15response to interleukin-15 (GO:0070672)3.70011995
16positive regulation by organism of defense response of other organism involved in symbiotic interact3.68833919
17modulation by symbiont of host immune response (GO:0052553)3.68833919
18positive regulation by symbiont of host defense response (GO:0052509)3.68833919
19modulation by symbiont of host defense response (GO:0052031)3.68833919
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.68833919
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.68833919
22urea cycle (GO:0000050)3.64368562
23urea metabolic process (GO:0019627)3.64368562
24negative regulation of interleukin-12 production (GO:0032695)3.60609336
25neutrophil activation involved in immune response (GO:0002283)3.60518365
26regulation of memory T cell differentiation (GO:0043380)3.59399405
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.54017320
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.54017320
29lysine metabolic process (GO:0006553)3.51830337
30lysine catabolic process (GO:0006554)3.51830337
31regulation of fibrinolysis (GO:0051917)3.50377927
32linoleic acid metabolic process (GO:0043651)3.47178047
33RNA localization (GO:0006403)3.47124736
34negative regulation of lymphocyte mediated immunity (GO:0002707)3.45593467
35neutrophil activation (GO:0042119)3.44752303
36positive regulation of interferon-beta production (GO:0032728)3.42224286
37positive regulation of interferon-alpha production (GO:0032727)3.42219716
38glyoxylate metabolic process (GO:0046487)3.42154361
39indole-containing compound catabolic process (GO:0042436)3.41907933
40indolalkylamine catabolic process (GO:0046218)3.41907933
41tryptophan catabolic process (GO:0006569)3.41907933
42positive regulation of toll-like receptor signaling pathway (GO:0034123)3.36831535
43tryptophan metabolic process (GO:0006568)3.36298688
44cellular extravasation (GO:0045123)3.35955313
45regulation of interferon-alpha production (GO:0032647)3.34572938
46negative regulation of T cell mediated immunity (GO:0002710)3.34286323
47triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.33967020
48macrophage differentiation (GO:0030225)3.30585235
49antigen processing and presentation of endogenous antigen (GO:0019883)3.27499679
50detection of other organism (GO:0098543)3.26618604
51reverse cholesterol transport (GO:0043691)3.25966684
52response to peptidoglycan (GO:0032494)3.25770569
53positive regulation of interleukin-17 production (GO:0032740)3.24094917
54phospholipid homeostasis (GO:0055091)3.22552255
55complement activation, alternative pathway (GO:0006957)3.22160262
56positive regulation of granulocyte differentiation (GO:0030854)3.18522946
57nitrogen cycle metabolic process (GO:0071941)3.17736839
58regulation of T cell mediated cytotoxicity (GO:0001914)3.17601270
59detection of bacterium (GO:0016045)3.16147961
60aromatic amino acid family catabolic process (GO:0009074)3.14284471
61high-density lipoprotein particle remodeling (GO:0034375)3.14041211
62immunoglobulin mediated immune response (GO:0016064)3.13249155
63peptidyl-glutamic acid carboxylation (GO:0017187)3.13076625
64protein carboxylation (GO:0018214)3.13076625
65positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11793397
66regulation of fatty acid beta-oxidation (GO:0031998)3.10841593
67neutrophil mediated immunity (GO:0002446)3.09513333
68retina vasculature morphogenesis in camera-type eye (GO:0061299)3.08273928
69leukocyte aggregation (GO:0070486)3.08025117
70amino-acid betaine metabolic process (GO:0006577)3.07651236
71regulation of B cell differentiation (GO:0045577)3.06356756
72primary alcohol catabolic process (GO:0034310)3.05634781
73positive regulation of B cell differentiation (GO:0045579)3.05539994
74G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.05459103
75L-phenylalanine metabolic process (GO:0006558)3.03953505
76erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.03953505
77* spliceosomal tri-snRNP complex assembly (GO:0000244)3.03721589
78regulation of natural killer cell mediated immunity (GO:0002715)3.03232898
79regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.03232898
80regulation of interferon-beta biosynthetic process (GO:0045357)3.01341993
81macrophage activation involved in immune response (GO:0002281)3.01141311
82ethanol oxidation (GO:0006069)3.00842763
83erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.00325310
84L-phenylalanine catabolic process (GO:0006559)3.00325310
85positive regulation of gamma-delta T cell activation (GO:0046645)3.00298687
86granulocyte activation (GO:0036230)2.99118240
87mitochondrion distribution (GO:0048311)2.99008759
88low-density lipoprotein particle clearance (GO:0034383)2.98995907
89imidazole-containing compound metabolic process (GO:0052803)2.98993572
902-oxoglutarate metabolic process (GO:0006103)2.98432500
91regulation of interferon-beta production (GO:0032648)2.97474545
92tolerance induction (GO:0002507)2.96969972
93regulation of cholesterol storage (GO:0010885)2.96450067
944-hydroxyproline metabolic process (GO:0019471)2.95582804
95fatty acid transmembrane transport (GO:1902001)2.94483361
96positive regulation of defense response to virus by host (GO:0002230)2.94410683
97dicarboxylic acid biosynthetic process (GO:0043650)2.94382559
98plasma lipoprotein particle clearance (GO:0034381)2.94343189
99negative regulation of leukocyte mediated immunity (GO:0002704)2.94044338
100detection of external biotic stimulus (GO:0098581)2.93874636
101regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93811162
102B cell receptor signaling pathway (GO:0050853)2.93735960
103fatty acid beta-oxidation (GO:0006635)2.92570665
104regulation of triglyceride catabolic process (GO:0010896)2.92221486
105microglial cell activation (GO:0001774)2.91797532
106type I interferon signaling pathway (GO:0060337)2.91604103
107cellular response to type I interferon (GO:0071357)2.91604103
108detection of molecule of bacterial origin (GO:0032490)2.90968849
109response to type I interferon (GO:0034340)2.90848138
110regulation of protein activation cascade (GO:2000257)2.89371742
111retinol metabolic process (GO:0042572)2.88931963
112fatty acid oxidation (GO:0019395)2.88516101
113phospholipid efflux (GO:0033700)2.88224381
114acylglycerol homeostasis (GO:0055090)2.87834923
115triglyceride homeostasis (GO:0070328)2.87834923
116mast cell activation (GO:0045576)2.87042005
117interferon-gamma production (GO:0032609)2.86704930
118growth hormone receptor signaling pathway (GO:0060396)2.86110790
119homocysteine metabolic process (GO:0050667)2.85771114
120regulation of T cell tolerance induction (GO:0002664)2.85770001
121positive regulation of histone deacetylation (GO:0031065)2.85484671
122regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.85321736
123positive regulation of fatty acid beta-oxidation (GO:0032000)2.84805636
124regulation of leukocyte mediated cytotoxicity (GO:0001910)2.84458794
125regulation of alpha-beta T cell proliferation (GO:0046640)2.83148140
126positive regulation of mast cell activation (GO:0033005)2.82443099
127positive thymic T cell selection (GO:0045059)2.82105925
128purinergic nucleotide receptor signaling pathway (GO:0035590)2.81796652
129regulation of tolerance induction (GO:0002643)2.79465534
130lipid oxidation (GO:0034440)2.78535290
131response to host immune response (GO:0052572)2.78390188
132response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.78390188
133positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.77000655
134carnitine metabolic process (GO:0009437)2.76310114
135negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.75934226
136negative regulation of cholesterol transport (GO:0032375)2.75119569
137negative regulation of sterol transport (GO:0032372)2.75119569
138regulation of sequestering of triglyceride (GO:0010889)2.74564078
139carnitine shuttle (GO:0006853)2.73855060
140myeloid cell activation involved in immune response (GO:0002275)2.73218534
141negative regulation of lipase activity (GO:0060192)2.73180326
142regulation of cell killing (GO:0031341)2.72401168
143regulation of response to osmotic stress (GO:0047484)2.72172945
144bile acid biosynthetic process (GO:0006699)2.70466471
145regulation of germinal center formation (GO:0002634)2.70350054
146axon extension involved in axon guidance (GO:0048846)2.70340047
147neuron projection extension involved in neuron projection guidance (GO:1902284)2.70340047
148positive regulation of mitochondrial membrane permeability (GO:0035794)2.70298795
149negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.69886982
150regulation of complement activation (GO:0030449)2.68884056
151necrotic cell death (GO:0070265)2.68588234
152regulation of mast cell activation (GO:0033003)2.68438026
153positive regulation of antigen processing and presentation (GO:0002579)2.68102325
154detection of biotic stimulus (GO:0009595)2.68081788
155regulation of cholesterol homeostasis (GO:2000188)2.66635423
156cellular response to epidermal growth factor stimulus (GO:0071364)2.65822092
157myeloid leukocyte mediated immunity (GO:0002444)2.65708483
158hormone catabolic process (GO:0042447)2.65605868
159T cell migration (GO:0072678)2.64868362
160response to interferon-beta (GO:0035456)2.64659815
161protein-lipid complex assembly (GO:0065005)2.64110665
162T cell selection (GO:0045058)2.63805924
163positive regulation of cell killing (GO:0031343)2.63283666
164regulation of interleukin-17 production (GO:0032660)2.63004627
165necroptotic process (GO:0070266)2.61638227
166programmed necrotic cell death (GO:0097300)2.60935862
167ethanol metabolic process (GO:0006067)2.59609518
168regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.59247625
169plasma lipoprotein particle assembly (GO:0034377)2.56352872
170vascular endothelial growth factor signaling pathway (GO:0038084)2.55387392
171plasma lipoprotein particle remodeling (GO:0034369)2.52878198
172protein-lipid complex remodeling (GO:0034368)2.52878198
173macromolecular complex remodeling (GO:0034367)2.52878198
174sulfur amino acid catabolic process (GO:0000098)2.45404148
175blood vessel endothelial cell migration (GO:0043534)2.44778452
176fatty acid catabolic process (GO:0009062)2.44564146
177monocarboxylic acid catabolic process (GO:0072329)2.44526773
178valine metabolic process (GO:0006573)2.43977262
179primary alcohol metabolic process (GO:0034308)2.43799814
180sodium-independent organic anion transport (GO:0043252)2.43618358
181positive regulation of lipid storage (GO:0010884)2.42277312
182regulation of gamma-delta T cell differentiation (GO:0045586)2.41974782
183negative thymic T cell selection (GO:0045060)2.40956020
184carnitine transmembrane transport (GO:1902603)2.40161601
185positive T cell selection (GO:0043368)2.40031067
186positive regulation of lipid catabolic process (GO:0050996)2.39946769
187fibrinolysis (GO:0042730)2.39704288
188negative T cell selection (GO:0043383)2.38361181
189regulation of fatty acid oxidation (GO:0046320)2.38333269
190cholesterol efflux (GO:0033344)2.38207153
191pyrimidine nucleobase catabolic process (GO:0006208)2.38077792

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.73621871
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.11843348
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.05802090
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.77628261
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.77463980
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.49761222
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.33746759
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.90083220
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.81602055
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.77553598
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.73300033
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.72056374
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60118579
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.38334426
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.20307073
16MYC_22102868_ChIP-Seq_BL_Human2.13090010
17IGF1R_20145208_ChIP-Seq_DFB_Human1.97829361
18* SPI1_23547873_ChIP-Seq_NB4_Human1.94283540
19* SMAD_19615063_ChIP-ChIP_OVARY_Human1.90803713
20CLOCK_20551151_ChIP-Seq_293T_Human1.88495569
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85098368
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84565994
23STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81756626
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.81583677
25VDR_21846776_ChIP-Seq_THP-1_Human1.81260255
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.76063856
27SCL_19346495_ChIP-Seq_HPC-7_Human1.75718009
28TCF7_22412390_ChIP-Seq_EML_Mouse1.75291881
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.74203587
30GATA3_26560356_Chip-Seq_TH2_Human1.72509781
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69936724
32MAF_26560356_Chip-Seq_TH1_Human1.69475060
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67756490
34GATA3_27048872_Chip-Seq_THYMUS_Human1.66258461
35PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63673447
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62585053
37GBX2_23144817_ChIP-Seq_PC3_Human1.61379908
38UTX_26944678_Chip-Seq_JUKART_Human1.57448380
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.56868423
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.54980099
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54133189
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53883554
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.52286797
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51979057
45GATA1_22025678_ChIP-Seq_K562_Human1.47599033
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45305057
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.44597129
48TBX20_22328084_ChIP-Seq_HEART_Mouse1.44597129
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44138024
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43347734
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42560271
52RUNX_20019798_ChIP-Seq_JUKART_Human1.40894272
53LXR_22292898_ChIP-Seq_THP-1_Human1.40093659
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.39902247
55ZNF274_21170338_ChIP-Seq_K562_Hela1.39176450
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.37153892
57KDM2B_26808549_Chip-Seq_DND41_Human1.36749861
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36353410
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36184429
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36076379
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35229799
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35088508
63* GATA1_19941827_ChIP-Seq_MEL_Mouse1.34053492
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33307078
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30590235
66CIITA_25753668_ChIP-Seq_RAJI_Human1.27829259
67* SMRT_27268052_Chip-Seq_Bcells_Human1.27555720
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26181522
69* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26151944
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.25832710
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25174643
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.25024349
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22629373
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22005185
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21850030
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21039416
77RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19859139
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19316640
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18711417
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16353724
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14597732
82* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13833103
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12252444
84GATA2_19941826_ChIP-Seq_K562_Human1.11558225
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11437036
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10798674
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.10111893
88EGR1_19374776_ChIP-ChIP_THP-1_Human1.09922409
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.09360465
90SPI1_23127762_ChIP-Seq_K562_Human1.08909313
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08193723
92MYB_26560356_Chip-Seq_TH1_Human1.05558266
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04628225
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04137703
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03807396
96MYB_26560356_Chip-Seq_TH2_Human1.03621848
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03004584
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01797540
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00972859
100SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00972859
101LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00894013
102MAF_26560356_Chip-Seq_TH2_Human1.00488331
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00402826
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.00372757
105GATA1_19941826_ChIP-Seq_K562_Human0.99998758
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99964284
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99964284
108PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99662009
109TP63_17297297_ChIP-ChIP_HaCaT_Human0.99617426
110MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98933863
111* HNF4A_19822575_ChIP-Seq_HepG2_Human0.98740437
112RUNX1_22412390_ChIP-Seq_EML_Mouse0.97492635
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97466184
114NFE2_27457419_Chip-Seq_LIVER_Mouse0.96968704
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96938316
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96762096
117IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95919367
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95897774
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95629285
120VDR_24763502_ChIP-Seq_THP-1_Human0.95441430
121KDM2B_26808549_Chip-Seq_JURKAT_Human0.95139919
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95077462
123EZH2_27294783_Chip-Seq_NPCs_Mouse0.94718806
124NCOR1_26117541_ChIP-Seq_K562_Human0.94606087
125VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93698331
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93120789
127* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93075949
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93061470
129GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92926005
130P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92174972
131ER_23166858_ChIP-Seq_MCF-7_Human0.90717797
132ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90428616
133BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90408443
134GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89424179
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89348794
136VDR_24787735_ChIP-Seq_THP-1_Human0.88394048
137VDR_22108803_ChIP-Seq_LS180_Human0.87421969
138BCAT_22108803_ChIP-Seq_LS180_Human0.87394265
139RACK7_27058665_Chip-Seq_MCF-7_Human0.87278987
140ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86900836
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86636008
142P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86595022
143IRF1_19129219_ChIP-ChIP_H3396_Human0.83406846
144BCL6_27268052_Chip-Seq_Bcells_Human0.83378269
145STAT3_23295773_ChIP-Seq_U87_Human0.83227848
146POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82541326
147GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82394743
148CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82017043
149RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81682524
150GATA3_26560356_Chip-Seq_TH1_Human0.80469742
151PU_27001747_Chip-Seq_BMDM_Mouse0.80032100
152TP53_22573176_ChIP-Seq_HFKS_Human0.79340267
153OCT4_21477851_ChIP-Seq_ESCs_Mouse0.79297464
154STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79016620
155* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78546112
156PRDM14_20953172_ChIP-Seq_ESCs_Human0.78464800
157FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77306928
158CRX_20693478_ChIP-Seq_RETINA_Mouse0.77103241
159* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76401692
160DROSHA_22980978_ChIP-Seq_HELA_Human0.75747365
161CDX2_19796622_ChIP-Seq_MESCs_Mouse0.74837828
162TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.74559261

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.95005846
2MP0003724_increased_susceptibility_to3.91418962
3MP0005671_abnormal_response_to3.86559852
4MP0005360_urolithiasis3.80775999
5MP0002139_abnormal_hepatobiliary_system3.74659839
6MP0005365_abnormal_bile_salt3.22971616
7MP0009785_altered_susceptibility_to2.96889871
8MP0005670_abnormal_white_adipose2.79014309
9MP0005000_abnormal_immune_tolerance2.74086971
10MP0005085_abnormal_gallbladder_physiolo2.67176757
11MP0003705_abnormal_hypodermis_morpholog2.64991639
12MP0004019_abnormal_vitamin_homeostasis2.55590564
13MP0003252_abnormal_bile_duct2.54610036
14MP0010329_abnormal_lipoprotein_level2.48909948
15MP0005666_abnormal_adipose_tissue2.43989098
16MP0000569_abnormal_digit_pigmentation2.43760375
17MP0002148_abnormal_hypersensitivity_rea2.41928832
18MP0003300_gastrointestinal_ulcer2.41757318
19MP0001958_emphysema2.32174527
20MP0002405_respiratory_system_inflammati2.01318946
21MP0009278_abnormal_bone_marrow1.91952734
22MP0010368_abnormal_lymphatic_system1.88272668
23MP0000015_abnormal_ear_pigmentation1.86730770
24MP0005075_abnormal_melanosome_morpholog1.80958325
25MP0000716_abnormal_immune_system1.78703156
26MP0006082_CNS_inflammation1.76601775
27MP0003880_abnormal_central_pattern1.75680651
28MP0001533_abnormal_skeleton_physiology1.75190623
29MP0010155_abnormal_intestine_physiology1.70920326
30MP0000609_abnormal_liver_physiology1.68765843
31MP0003866_abnormal_defecation1.65274597
32MP0008875_abnormal_xenobiotic_pharmacok1.63522135
33MP0000689_abnormal_spleen_morphology1.62274142
34MP0001986_abnormal_taste_sensitivity1.59807974
35MP0003172_abnormal_lysosome_physiology1.57429939
36MP0003191_abnormal_cellular_cholesterol1.55489464
37MP0001851_eye_inflammation1.48155428
38MP0002722_abnormal_immune_system1.47630973
39MP0005375_adipose_tissue_phenotype1.46867597
40MP0005083_abnormal_biliary_tract1.41580273
41MP0002971_abnormal_brown_adipose1.40081005
42MP0009840_abnormal_foam_cell1.40025318
43MP0005423_abnormal_somatic_nervous1.39326555
44MP0004381_abnormal_hair_follicle1.38866205
45MP0002138_abnormal_hepatobiliary_system1.37304090
46MP0000371_diluted_coat_color1.37149684
47MP0005451_abnormal_body_composition1.35803016
48MP0005310_abnormal_salivary_gland1.35765914
49MP0005501_abnormal_skin_physiology1.35642386
50MP0002429_abnormal_blood_cell1.35288230
51MP0004947_skin_inflammation1.33484742
52MP0003566_abnormal_cell_adhesion1.33175201
53MP0003436_decreased_susceptibility_to1.32379442
54MP0003828_pulmonary_edema1.31955434
55MP0009333_abnormal_splenocyte_physiolog1.30058550
56MP0000703_abnormal_thymus_morphology1.29271365
57MP0005174_abnormal_tail_pigmentation1.29000687
58MP0005058_abnormal_lysosome_morphology1.27135230
59MP0001666_abnormal_nutrient_absorption1.26483694
60MP0005076_abnormal_cell_differentiation1.25998525
61MP0002166_altered_tumor_susceptibility1.24522050
62MP0003303_peritoneal_inflammation1.23143050
63MP0009115_abnormal_fat_cell1.22938614
64MP0001545_abnormal_hematopoietic_system1.20483443
65MP0005397_hematopoietic_system_phenotyp1.20483443
66MP0008961_abnormal_basal_metabolism1.18661199
67MP0003878_abnormal_ear_physiology1.15989054
68MP0005377_hearing/vestibular/ear_phenot1.15989054
69MP0000465_gastrointestinal_hemorrhage1.14680031
70MP0005464_abnormal_platelet_physiology1.12303430
71MP0001879_abnormal_lymphatic_vessel1.11187091
72MP0001800_abnormal_humoral_immune1.10644748
73MP0002118_abnormal_lipid_homeostasis1.10158416
74MP0010630_abnormal_cardiac_muscle1.09517284
75MP0002796_impaired_skin_barrier1.09048632
76MP0003656_abnormal_erythrocyte_physiolo1.08683059
77MP0009643_abnormal_urine_homeostasis1.08679797
78MP0003183_abnormal_peptide_metabolism1.06078249
79MP0002277_abnormal_respiratory_mucosa1.05983071
80MP0010307_abnormal_tumor_latency1.04684514
81MP0005334_abnormal_fat_pad1.04330118
82MP0000598_abnormal_liver_morphology1.02759743
83MP0005319_abnormal_enzyme/_coenzyme1.02634927
84MP0003763_abnormal_thymus_physiology1.02422154
85MP0003045_fibrosis1.00984038
86MP0001915_intracranial_hemorrhage1.00858990
87MP0002168_other_aberrant_phenotype0.99418452
88MP0009764_decreased_sensitivity_to0.99020897
89MP0000013_abnormal_adipose_tissue0.98717485
90MP0005332_abnormal_amino_acid0.96886429
91MP0005387_immune_system_phenotype0.96187646
92MP0001790_abnormal_immune_system0.96187646
93MP0002132_abnormal_respiratory_system0.94751661
94MP0008260_abnormal_autophagy0.94462166
95MP0002970_abnormal_white_adipose0.94128482
96MP0003279_aneurysm0.93645726
97MP0009765_abnormal_xenobiotic_induced0.92283047
98MP0002933_joint_inflammation0.91692909
99MP0004883_abnormal_blood_vessel0.90658309
100MP0001835_abnormal_antigen_presentation0.90632704
101MP0004130_abnormal_muscle_cell0.90491575
102MP0005330_cardiomyopathy0.90312270
103MP0005275_abnormal_skin_tensile0.89880626
104MP0000604_amyloidosis0.89492932
105MP0001191_abnormal_skin_condition0.89296706
106MP0009763_increased_sensitivity_to0.88876186
107MP0004885_abnormal_endolymph0.88815413
108MP0008438_abnormal_cutaneous_collagen0.86518239
109MP0010386_abnormal_urinary_bladder0.84456059
110MP0005551_abnormal_eye_electrophysiolog0.84314728
111MP0004087_abnormal_muscle_fiber0.84017760
112MP0001216_abnormal_epidermal_layer0.83906031
113MP0005645_abnormal_hypothalamus_physiol0.83821246
114MP0002928_abnormal_bile_duct0.83820320
115MP0001501_abnormal_sleep_pattern0.83709687
116MP0005025_abnormal_response_to0.83212977
117MP0002452_abnormal_antigen_presenting0.81434371
118MP0000685_abnormal_immune_system0.81148875
119MP0002128_abnormal_blood_circulation0.80934803
120MP0000377_abnormal_hair_follicle0.80856906
121MP0002254_reproductive_system_inflammat0.80756281
122MP0002060_abnormal_skin_morphology0.80448024
123MP0000343_altered_response_to0.79569244
124MP0003221_abnormal_cardiomyocyte_apopto0.79312789
125MP0008469_abnormal_protein_level0.78785398
126MP0003195_calcinosis0.77082518
127MP0002420_abnormal_adaptive_immunity0.76895901
128MP0001663_abnormal_digestive_system0.76846541
129MP0002398_abnormal_bone_marrow0.76388005
130MP0009053_abnormal_anal_canal0.75014640
131MP0001764_abnormal_homeostasis0.74809241
132MP0002998_abnormal_bone_remodeling0.74502813
133MP0002638_abnormal_pupillary_reflex0.74491569
134MP0009672_abnormal_birth_weight0.73920021
135MP0000858_altered_metastatic_potential0.73864401
136MP0001819_abnormal_immune_cell0.73635483
137MP0010352_gastrointestinal_tract_polyps0.73379827
138MP0002136_abnormal_kidney_physiology0.72540634
139MP0000249_abnormal_blood_vessel0.71832446
140MP0004185_abnormal_adipocyte_glucose0.71021472
141MP0003453_abnormal_keratinocyte_physiol0.70471530
142MP0005023_abnormal_wound_healing0.69399576
143MP0005164_abnormal_response_to0.68952752
144MP0002735_abnormal_chemical_nociception0.68940481
145MP0009931_abnormal_skin_appearance0.68890316
146MP0004484_altered_response_of0.68802003
147MP0002419_abnormal_innate_immunity0.68342311
148MP0002396_abnormal_hematopoietic_system0.68241889
149MP0002078_abnormal_glucose_homeostasis0.68212592
150MP0002653_abnormal_ependyma_morphology0.68024282
151MP0010234_abnormal_vibrissa_follicle0.67986929
152MP0000372_irregular_coat_pigmentation0.67801896
153MP0002006_tumorigenesis0.67106749
154MP0001873_stomach_inflammation0.67027546
155MP0002723_abnormal_immune_serum0.66898684
156MP0001849_ear_inflammation0.66070255
157MP0005248_abnormal_Harderian_gland0.66062479
158MP0001845_abnormal_inflammatory_respons0.65684299
159MP0005390_skeleton_phenotype0.65445513
160MP0001968_abnormal_touch/_nociception0.63980031
161MP0001853_heart_inflammation0.63575827
162MP0002095_abnormal_skin_pigmentation0.62898794
163MP0008872_abnormal_physiological_respon0.60128892
164MP0004742_abnormal_vestibular_system0.59751555

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)5.98785648
2Retrobulbar optic neuritis (HP:0100654)5.98785648
3Myositis (HP:0100614)5.74900745
4Orchitis (HP:0100796)5.64764501
5Stomatitis (HP:0010280)4.66506296
6Hypoalphalipoproteinemia (HP:0003233)4.56235165
7Deep venous thrombosis (HP:0002625)4.39712573
8Keratoconjunctivitis sicca (HP:0001097)4.28433764
9Keratoconjunctivitis (HP:0001096)4.16483419
10Renovascular hypertension (HP:0100817)4.11294591
11Recurrent cutaneous fungal infections (HP:0011370)3.94747812
12Chronic mucocutaneous candidiasis (HP:0002728)3.94747812
13Elevated erythrocyte sedimentation rate (HP:0003565)3.90685078
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.82587546
15Recurrent fungal infections (HP:0002841)3.81579423
16Recurrent bacterial skin infections (HP:0005406)3.76674050
17Recurrent abscess formation (HP:0002722)3.76520353
18Encephalitis (HP:0002383)3.66319664
19Vascular calcification (HP:0004934)3.66001540
20Hypolipoproteinemia (HP:0010981)3.52103477
21Pulmonary infiltrates (HP:0002113)3.51410230
22Vasculitis (HP:0002633)3.49594286
23Cardiovascular calcification (HP:0011915)3.44917434
24Hemoptysis (HP:0002105)3.40196398
25Increased IgM level (HP:0003496)3.36007610
26Abnormality of T cell number (HP:0011839)3.33181385
27T lymphocytopenia (HP:0005403)3.20552174
28Abnormality of fatty-acid metabolism (HP:0004359)3.19288358
29Meningitis (HP:0001287)3.18496001
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.14901848
31Recurrent skin infections (HP:0001581)3.12135365
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.09163726
33Joint hemorrhage (HP:0005261)3.01295595
34Mediastinal lymphadenopathy (HP:0100721)3.00166257
35Mitral stenosis (HP:0001718)2.94285484
36Progressive inability to walk (HP:0002505)2.93673733
37IgG deficiency (HP:0004315)2.91256871
38Prolonged partial thromboplastin time (HP:0003645)2.88150519
39Abnormality of macrophages (HP:0004311)2.87642691
40Abnormality of T cells (HP:0002843)2.84097808
41Abnormality of eosinophils (HP:0001879)2.81228908
42Leukocytosis (HP:0001974)2.80237069
43Agammaglobulinemia (HP:0004432)2.79333525
44Panhypogammaglobulinemia (HP:0003139)2.77148091
45Gastrointestinal infarctions (HP:0005244)2.74822510
46Eosinophilia (HP:0001880)2.74227248
47Hip dysplasia (HP:0001385)2.73686212
48Pustule (HP:0200039)2.70699006
49Urticaria (HP:0001025)2.69145976
50Granulocytopenia (HP:0001913)2.66813541
51Abnormality of monocarboxylic acid metabolism (HP:0010996)2.64934119
52Anorexia (HP:0002039)2.64615695
53Xanthomatosis (HP:0000991)2.59963159
54Arterial thrombosis (HP:0004420)2.59721631
55Complement deficiency (HP:0004431)2.59195640
56Hyperacusis (HP:0010780)2.57902922
57Stomach cancer (HP:0012126)2.56597699
58Chronic hepatic failure (HP:0100626)2.52911529
59Ketosis (HP:0001946)2.52119690
60Muscle fiber splitting (HP:0003555)2.48462880
61Hand muscle atrophy (HP:0009130)2.47511725
62Right ventricular cardiomyopathy (HP:0011663)2.47449122
63Frequent falls (HP:0002359)2.47113159
64Recurrent bronchitis (HP:0002837)2.46896247
65Subcapsular cataract (HP:0000523)2.46425707
66Prolonged bleeding time (HP:0003010)2.46225219
67Gingivitis (HP:0000230)2.46125066
68Myoglobinuria (HP:0002913)2.46058624
69Intrahepatic cholestasis (HP:0001406)2.44161170
70Abnormality of sulfur amino acid metabolism (HP:0004339)2.43606867
71Abnormality of T cell physiology (HP:0011840)2.43598410
72Eczematoid dermatitis (HP:0000976)2.43022256
73Myocardial infarction (HP:0001658)2.41179954
74Hypoglycemic coma (HP:0001325)2.41113847
75Hypobetalipoproteinemia (HP:0003563)2.40850138
76Abnormality of the pleura (HP:0002103)2.39937220
77Elfin facies (HP:0004428)2.38479729
78Asymmetric septal hypertrophy (HP:0001670)2.37968475
79Recurrent gram-negative bacterial infections (HP:0005420)2.37517620
80Polyneuropathy (HP:0001271)2.35747565
81Keratitis (HP:0000491)2.35338290
82Hypercholesterolemia (HP:0003124)2.33731452
83Autoimmune hemolytic anemia (HP:0001890)2.33254093
84Aortic aneurysm (HP:0004942)2.32781496
85Autoimmune thrombocytopenia (HP:0001973)2.32383465
86Chronic otitis media (HP:0000389)2.32238259
87Hyperlipoproteinemia (HP:0010980)2.32046977
88Cone-rod dystrophy (HP:0000548)2.31254425
89Gangrene (HP:0100758)2.31161816
90Pulmonary embolism (HP:0002204)2.29141630
91Abnormality of the endocardium (HP:0004306)2.28569743
92Cerebral aneurysm (HP:0004944)2.27816376
93Hypochromic anemia (HP:0001931)2.26299317
94Gastrointestinal stroma tumor (HP:0100723)2.25256110
95Severe combined immunodeficiency (HP:0004430)2.22602306
96Hypergammaglobulinemia (HP:0010702)2.19928426
97Abnormality of the fingertips (HP:0001211)2.19907137
98Epidermoid cyst (HP:0200040)2.18827010
99Chest pain (HP:0100749)2.17089155
100Lymphopenia (HP:0001888)2.13567571
101Recurrent viral infections (HP:0004429)2.12402105
102Obstructive lung disease (HP:0006536)2.12263645
103Chronic obstructive pulmonary disease (HP:0006510)2.12263645
104Inability to walk (HP:0002540)2.11784688
105Abnormality of complement system (HP:0005339)2.10033362
106Poikilocytosis (HP:0004447)2.09239577
107Spinal muscular atrophy (HP:0007269)2.08826387
108Cardiomegaly (HP:0001640)2.06135814
109Albinism (HP:0001022)2.05878676
110Nephrocalcinosis (HP:0000121)2.05695358
111Nasal polyposis (HP:0100582)2.05554272
112Tubulointerstitial nephritis (HP:0001970)2.04141172
113Hypochromic microcytic anemia (HP:0004840)2.03852677
114Insulin-resistant diabetes mellitus (HP:0000831)2.03522650
115Spontaneous hematomas (HP:0007420)2.03510188
116Abnormality of the common coagulation pathway (HP:0010990)2.02876829
117Hypertriglyceridemia (HP:0002155)2.01020850
118Epistaxis (HP:0000421)2.00826556
119Aneurysm (HP:0002617)1.99372855
120Periodontitis (HP:0000704)1.98891691
121Ketoacidosis (HP:0001993)1.97911729
122Abnormality of cells of the lymphoid lineage (HP:0012140)1.96607328
123Congenital sensorineural hearing impairment (HP:0008527)1.95481531
124Hyperammonemia (HP:0001987)1.95084595
125Vertigo (HP:0002321)1.94687462
126Generalized aminoaciduria (HP:0002909)1.94666476
127Renal cortical cysts (HP:0000803)1.94345686
128True hermaphroditism (HP:0010459)1.93163726
129Episodic fever (HP:0001954)1.92781242
130Neonatal death (HP:0003811)1.92768833
131Abnormality of the vocal cords (HP:0008777)1.92710142
132Abnormality of the nasal mucosa (HP:0000433)1.92638856
133Hepatitis (HP:0012115)1.92346576
134Congenital stationary night blindness (HP:0007642)1.91219266
135Hyperglycinuria (HP:0003108)1.90825636
136Lymphangioma (HP:0100764)1.90571067
137Cholelithiasis (HP:0001081)1.90367339
138Thyroiditis (HP:0100646)1.90318369
139Esophageal varix (HP:0002040)1.88781819
140Abnormality of pyrimidine metabolism (HP:0004353)1.87973374
141Papilledema (HP:0001085)1.87875375
142Long toe (HP:0010511)1.87861756
143Heterotopia (HP:0002282)1.87705257
144Rhabdomyolysis (HP:0003201)1.86361444
145Abnormality of glutamine family amino acid metabolism (HP:0010902)1.85118074
146Nephritis (HP:0000123)1.84852195
147Ventricular tachycardia (HP:0004756)1.84496808
148Glomerulopathy (HP:0100820)1.84045909
149Hepatocellular carcinoma (HP:0001402)1.83373277
150Abnormality of B cell number (HP:0010975)1.82734327
151Inflammation of the large intestine (HP:0002037)1.82680785
152Recurrent sinusitis (HP:0011108)1.82190570
153Joint swelling (HP:0001386)1.81292661
154Abnormality of aromatic amino acid family metabolism (HP:0004338)1.80648434
155Absent frontal sinuses (HP:0002688)1.79947661
156Abnormality of the pericardium (HP:0001697)1.79751592
157Abnormality of midbrain morphology (HP:0002418)1.79050229
158Molar tooth sign on MRI (HP:0002419)1.79050229
159Hyperventilation (HP:0002883)1.78607507
160Increased IgE level (HP:0003212)1.78202761
161Increased cerebral lipofuscin (HP:0011813)1.77050640
162Increased neuronal autofluorescent lipopigment (HP:0002074)1.76762592
163Increased CSF protein (HP:0002922)1.76705361
164Polycythemia (HP:0001901)1.75879780
165Obstructive sleep apnea (HP:0002870)1.74468065
166Pancreatic cysts (HP:0001737)1.74056861
167Chronic diarrhea (HP:0002028)1.73825857
168Hypoproteinemia (HP:0003075)1.73777462
169Abnormality of nucleobase metabolism (HP:0010932)1.73504401
170Peritonitis (HP:0002586)1.72997636
171Portal hypertension (HP:0001409)1.72973484
172Microcytic anemia (HP:0001935)1.72692030
173Progressive sensorineural hearing impairment (HP:0000408)1.72302886
174Abnormality of the peritoneum (HP:0002585)1.72283177
175Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70477083
176Bowel diverticulosis (HP:0005222)1.68547704
177Abnormal platelet volume (HP:0011876)1.68012981
178Short 4th metacarpal (HP:0010044)1.66363576
179Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66363576
180Abnormality of purine metabolism (HP:0004352)1.66269915
181Cortical dysplasia (HP:0002539)1.65794601
182Obsessive-compulsive behavior (HP:0000722)1.65129624
183Abnormal gallbladder morphology (HP:0012437)1.63297712
184Bladder diverticulum (HP:0000015)1.61690703
185Reticulocytosis (HP:0001923)1.61665465
186Truncal obesity (HP:0001956)1.61178921
187Exercise-induced myalgia (HP:0003738)1.59368724
188High pitched voice (HP:0001620)1.58677675
189Overriding aorta (HP:0002623)1.58434475
190Hemorrhage of the eye (HP:0011885)1.57972638
191Hyperphosphatemia (HP:0002905)1.56762988
192Acanthosis nigricans (HP:0000956)1.56369217
193Gingival bleeding (HP:0000225)1.56081022
194Acanthocytosis (HP:0001927)1.55635168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.17193975
2FES3.57109989
3MAP3K103.36049697
4FGFR43.24733122
5PTK63.09550058
6PKN23.08151378
7TRIB33.04484268
8RIPK42.92885767
9CDK122.31301699
10ERN12.23578527
11SIK32.23290878
12TTN2.19988857
13MAP4K12.11519453
14SIK12.03305114
15FRK2.00674526
16VRK11.87948723
17TNK21.85962720
18PRPF4B1.80734055
19TAOK31.76927267
20INSRR1.70633217
21TESK11.64251878
22TNIK1.63299095
23WNK31.58494055
24STK101.56445343
25JAK11.49663352
26IRAK41.49478117
27ADRBK21.48166685
28TYK21.47751338
29FGFR31.46166260
30LYN1.44056005
31MAPKAPK31.34468750
32NEK91.34056479
33TEC1.33534383
34JAK31.32035461
35NLK1.28938595
36RIPK11.27258556
37FGFR21.19336538
38LATS11.19279941
39SGK31.18963178
40MAP2K61.18842005
41IKBKB1.18518297
42ZAP701.18368338
43TRPM71.14840893
44RET1.12622554
45ITK1.11286471
46HCK1.11166160
47IRAK11.08108448
48BCKDK1.05807447
49MAP2K31.05461546
50TGFBR21.05088329
51TXK1.04364331
52MARK31.01928256
53TYRO31.01611379
54PRKD20.99283512
55TRIM280.98730816
56MAPK70.97494224
57ZAK0.97308231
58SGK20.95636249
59CAMK1D0.94055155
60LRRK20.93606622
61PDGFRA0.93449291
62CLK10.92102335
63SIK20.91862659
64EPHA30.90919052
65JAK20.88764901
66BMPR20.88370688
67MAPK110.87675301
68PIK3CG0.87496708
69PRKCH0.86914527
70RPS6KB20.86603315
71EPHB20.86245604
72MTOR0.85723347
73FGR0.85606051
74STK380.85448995
75PDK40.85220281
76PDK30.85220281
77MATK0.84476864
78BTK0.84453712
79OXSR10.84099757
80ACVR1B0.84094325
81BLK0.84071526
82MAPK130.83354340
83FGFR10.81174471
84PIK3CA0.79334940
85ICK0.79021343
86TLK10.78609961
87MAP4K20.77759174
88CAMK1G0.77467181
89FLT30.76922528
90PRKCQ0.76041808
91PTK2B0.75805343
92KIT0.75581710
93DAPK20.73281696
94PRKD30.72856822
95KDR0.72048786
96PIM10.71750021
97STK110.71521543
98NUAK10.69816435
99MAP3K70.67752051
100SYK0.66064892
101CSK0.64121730
102PRKAA10.63066239
103MAP3K50.62751071
104TTK0.62658918
105CAMKK20.62553506
106PASK0.61125163
107IRAK30.60619662
108MAP3K10.60611943
109PDGFRB0.60118279
110ADRBK10.60063359
111MARK10.59510813
112PTK20.59177707
113CDC42BPA0.58998898
114MAPK120.58606448
115RPS6KA20.58097453
116BCR0.58007655
117PRKAA20.57310526
118TGFBR10.56640348
119CDK90.56391735
120DYRK1B0.56271790
121TAOK10.55721105
122PRKCE0.54803855
123HIPK20.54703148
124RPS6KB10.54628027
125BMX0.53349103
126CCNB10.53346175
127YES10.52239476
128EPHB10.51598776
129CDK60.50426606
130MELK0.50237049
131LCK0.50005674
132FER0.49423240
133MARK20.49278982
134GRK70.49215201
135PRKD10.49016756
136MAP3K30.47948276
137MAP3K130.47439259
138TBK10.47323352
139CDK40.46933989
140MAP3K140.46185112
141IKBKE0.45394491
142PDK10.45391184
143CAMKK10.45153673
144FYN0.43312109
145STK38L0.42219686
146BRD40.41970604
147ABL10.39846380
148STK30.39614752
149ATR0.39367753
150BMPR1B0.38917910
151CHUK0.37880330
152CAMK40.37710367
153GRK60.37547882
154CSF1R0.37141048
155GRK10.36091418

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95973569
2Fatty acid degradation_Homo sapiens_hsa000712.84891919
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.84545012
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.72213202
5Graft-versus-host disease_Homo sapiens_hsa053322.47735758
6Allograft rejection_Homo sapiens_hsa053302.27318661
7Complement and coagulation cascades_Homo sapiens_hsa046102.26946744
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26670381
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.25156811
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.23803088
11PPAR signaling pathway_Homo sapiens_hsa033202.23434178
12Tryptophan metabolism_Homo sapiens_hsa003802.21512446
13Lysine degradation_Homo sapiens_hsa003102.15952333
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.06858639
15Autoimmune thyroid disease_Homo sapiens_hsa053202.05167189
16Fatty acid metabolism_Homo sapiens_hsa012122.03438840
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.00291958
18Propanoate metabolism_Homo sapiens_hsa006401.99289486
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.99254783
20Starch and sucrose metabolism_Homo sapiens_hsa005001.98293709
21Staphylococcus aureus infection_Homo sapiens_hsa051501.88330115
22Selenocompound metabolism_Homo sapiens_hsa004501.87423642
23Arginine biosynthesis_Homo sapiens_hsa002201.87314587
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.81165618
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.78052135
26Asthma_Homo sapiens_hsa053101.77666850
27Hematopoietic cell lineage_Homo sapiens_hsa046401.76306199
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75098672
29Tuberculosis_Homo sapiens_hsa051521.74118845
30Malaria_Homo sapiens_hsa051441.67804827
31Type I diabetes mellitus_Homo sapiens_hsa049401.65868829
32Retinol metabolism_Homo sapiens_hsa008301.55539554
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55129440
34Insulin resistance_Homo sapiens_hsa049311.41333256
35Regulation of autophagy_Homo sapiens_hsa041401.39469168
36ABC transporters_Homo sapiens_hsa020101.39018905
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38336171
38Caffeine metabolism_Homo sapiens_hsa002321.36149274
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36124145
40Nitrogen metabolism_Homo sapiens_hsa009101.35729204
41Chemokine signaling pathway_Homo sapiens_hsa040621.35003988
42Dorso-ventral axis formation_Homo sapiens_hsa043201.33387020
43Peroxisome_Homo sapiens_hsa041461.33240434
44Hepatitis B_Homo sapiens_hsa051611.31329486
45Platelet activation_Homo sapiens_hsa046111.30969874
46Bile secretion_Homo sapiens_hsa049761.29913823
47One carbon pool by folate_Homo sapiens_hsa006701.25947742
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25443675
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25222688
50Influenza A_Homo sapiens_hsa051641.22599519
51beta-Alanine metabolism_Homo sapiens_hsa004101.20165988
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19992891
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18913097
54Legionellosis_Homo sapiens_hsa051341.14946966
55Acute myeloid leukemia_Homo sapiens_hsa052211.11699758
56Primary immunodeficiency_Homo sapiens_hsa053401.11597401
57Rheumatoid arthritis_Homo sapiens_hsa053231.10803331
58Linoleic acid metabolism_Homo sapiens_hsa005911.07898521
59Chemical carcinogenesis_Homo sapiens_hsa052041.06965701
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06479883
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05850845
62Drug metabolism - other enzymes_Homo sapiens_hsa009831.03570721
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02502139
64Pertussis_Homo sapiens_hsa051331.01428325
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00869662
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98895241
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.97494244
68African trypanosomiasis_Homo sapiens_hsa051430.97335810
69Carbon metabolism_Homo sapiens_hsa012000.97035462
70Butanoate metabolism_Homo sapiens_hsa006500.96981754
71Phenylalanine metabolism_Homo sapiens_hsa003600.96577382
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95531027
73Phagosome_Homo sapiens_hsa041450.95362755
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.95069830
75Tyrosine metabolism_Homo sapiens_hsa003500.90592141
76AMPK signaling pathway_Homo sapiens_hsa041520.90364385
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.90011485
78Fat digestion and absorption_Homo sapiens_hsa049750.89795148
79Viral myocarditis_Homo sapiens_hsa054160.89583185
80Shigellosis_Homo sapiens_hsa051310.87229971
81Glucagon signaling pathway_Homo sapiens_hsa049220.86749506
82Toxoplasmosis_Homo sapiens_hsa051450.86394547
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.85391490
84Osteoclast differentiation_Homo sapiens_hsa043800.81610769
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81595752
86Fatty acid elongation_Homo sapiens_hsa000620.81235990
87Collecting duct acid secretion_Homo sapiens_hsa049660.78459499
88Glycerolipid metabolism_Homo sapiens_hsa005610.77879878
89Biosynthesis of amino acids_Homo sapiens_hsa012300.77682183
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76928753
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76918988
92Pyruvate metabolism_Homo sapiens_hsa006200.75795788
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75453773
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.75357034
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75281485
96Lysosome_Homo sapiens_hsa041420.74291411
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.72720696
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72586244
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72219885
100Small cell lung cancer_Homo sapiens_hsa052220.71435865
101mTOR signaling pathway_Homo sapiens_hsa041500.70547445
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70344625
103Adherens junction_Homo sapiens_hsa045200.69297205
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69048112
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68313582
106Ether lipid metabolism_Homo sapiens_hsa005650.68304207
107Measles_Homo sapiens_hsa051620.68270191
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67321390
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67282533
110Vitamin digestion and absorption_Homo sapiens_hsa049770.67050918
111Leishmaniasis_Homo sapiens_hsa051400.66574798
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65623556
113Circadian rhythm_Homo sapiens_hsa047100.65496452
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.65442275
115B cell receptor signaling pathway_Homo sapiens_hsa046620.63989260
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.62528327
117T cell receptor signaling pathway_Homo sapiens_hsa046600.62427320
118Hepatitis C_Homo sapiens_hsa051600.58939677
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58482493
120Fatty acid biosynthesis_Homo sapiens_hsa000610.58159028
121Chronic myeloid leukemia_Homo sapiens_hsa052200.57165743
122Insulin signaling pathway_Homo sapiens_hsa049100.57160217
123Phototransduction_Homo sapiens_hsa047440.56456742
124Apoptosis_Homo sapiens_hsa042100.56237625
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56114959
126Non-small cell lung cancer_Homo sapiens_hsa052230.55119358
127Arachidonic acid metabolism_Homo sapiens_hsa005900.54837078
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54674557
129Endometrial cancer_Homo sapiens_hsa052130.54283050
130Pentose phosphate pathway_Homo sapiens_hsa000300.53562121
131Galactose metabolism_Homo sapiens_hsa000520.52609127
132Type II diabetes mellitus_Homo sapiens_hsa049300.52186410
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.52073917
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52062144
135Systemic lupus erythematosus_Homo sapiens_hsa053220.52031799
136Prolactin signaling pathway_Homo sapiens_hsa049170.51686670
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.51166492
138MAPK signaling pathway_Homo sapiens_hsa040100.50463721
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49917419
140Histidine metabolism_Homo sapiens_hsa003400.49783834
141Antigen processing and presentation_Homo sapiens_hsa046120.49527944
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49459003
143Dilated cardiomyopathy_Homo sapiens_hsa054140.49001573
144Neurotrophin signaling pathway_Homo sapiens_hsa047220.48768654
145Focal adhesion_Homo sapiens_hsa045100.47598426
146Other glycan degradation_Homo sapiens_hsa005110.47228722
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46503649
148FoxO signaling pathway_Homo sapiens_hsa040680.46258668
149Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46056293
150Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45029294
151Central carbon metabolism in cancer_Homo sapiens_hsa052300.44881003
152Herpes simplex infection_Homo sapiens_hsa051680.44846227
153Pancreatic cancer_Homo sapiens_hsa052120.44228795
154Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44016974
155Notch signaling pathway_Homo sapiens_hsa043300.43009910
156Jak-STAT signaling pathway_Homo sapiens_hsa046300.42657354
157Inositol phosphate metabolism_Homo sapiens_hsa005620.42302579
158Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42247696
159Choline metabolism in cancer_Homo sapiens_hsa052310.41345321
160Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40938496
161Salmonella infection_Homo sapiens_hsa051320.40892727
162Mineral absorption_Homo sapiens_hsa049780.40494235
163TNF signaling pathway_Homo sapiens_hsa046680.39409077
164Epstein-Barr virus infection_Homo sapiens_hsa051690.38521506
165Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36314223
166Olfactory transduction_Homo sapiens_hsa047400.35847225
167Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35650826
168Oxytocin signaling pathway_Homo sapiens_hsa049210.35607689
169Colorectal cancer_Homo sapiens_hsa052100.33462768
170Endocytosis_Homo sapiens_hsa041440.32840096
171Viral carcinogenesis_Homo sapiens_hsa052030.32517569

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