USP40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP40 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration involved in heart development (GO:0060973)5.18782923
2positive regulation of endothelial cell apoptotic process (GO:2000353)5.08018423
3regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.87271201
4Golgi transport vesicle coating (GO:0048200)4.82910715
5COPI coating of Golgi vesicle (GO:0048205)4.82910715
6positive regulation of extracellular matrix organization (GO:1903055)4.68858673
7tryptophan metabolic process (GO:0006568)4.46971936
8positive regulation of fibroblast migration (GO:0010763)4.45528703
9indole-containing compound catabolic process (GO:0042436)4.41368138
10indolalkylamine catabolic process (GO:0046218)4.41368138
11tryptophan catabolic process (GO:0006569)4.41368138
12aromatic amino acid family catabolic process (GO:0009074)4.22293293
13L-phenylalanine catabolic process (GO:0006559)4.13204198
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.13204198
15insulin-like growth factor receptor signaling pathway (GO:0048009)4.06970446
16growth hormone receptor signaling pathway (GO:0060396)4.03923329
17cellular anion homeostasis (GO:0030002)3.98225156
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.92958698
19regulation of metalloenzyme activity (GO:0048552)3.84696491
20regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.76268105
21secondary heart field specification (GO:0003139)3.75225327
22heart field specification (GO:0003128)3.75225327
23cellular response to growth hormone stimulus (GO:0071378)3.73974263
24negative regulation of cell fate specification (GO:0009996)3.67864644
25urea cycle (GO:0000050)3.67203373
26urea metabolic process (GO:0019627)3.67203373
27phospholipid homeostasis (GO:0055091)3.62999619
28tyrosine metabolic process (GO:0006570)3.58341593
29reverse cholesterol transport (GO:0043691)3.56550764
30L-phenylalanine metabolic process (GO:0006558)3.55096573
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.55096573
32high-density lipoprotein particle remodeling (GO:0034375)3.54444695
33NAD biosynthetic process (GO:0009435)3.48171984
34kynurenine metabolic process (GO:0070189)3.48025212
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.47519826
36indolalkylamine metabolic process (GO:0006586)3.47461418
37homocysteine metabolic process (GO:0050667)3.43810200
38positive regulation of cellular amide metabolic process (GO:0034250)3.42168521
39bile acid biosynthetic process (GO:0006699)3.40784179
40hemidesmosome assembly (GO:0031581)3.38493280
41diterpenoid biosynthetic process (GO:0016102)3.37969351
42alpha-linolenic acid metabolic process (GO:0036109)3.36876000
43protein carboxylation (GO:0018214)3.34332958
44peptidyl-glutamic acid carboxylation (GO:0017187)3.34332958
45phospholipid efflux (GO:0033700)3.32073936
46complement activation, alternative pathway (GO:0006957)3.31269195
47cell adhesion mediated by integrin (GO:0033627)3.31070377
48regulation of triglyceride catabolic process (GO:0010896)3.30080707
49cellular glucuronidation (GO:0052695)3.25190106
50fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.24812531
51desmosome organization (GO:0002934)3.24419941
52regulation of protein activation cascade (GO:2000257)3.20158639
53amine catabolic process (GO:0009310)3.18675367
54cellular biogenic amine catabolic process (GO:0042402)3.18675367
55mesodermal cell differentiation (GO:0048333)3.18670144
56COPII vesicle coating (GO:0048208)3.14837657
57positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.14729474
58positive regulation of fatty acid beta-oxidation (GO:0032000)3.14221888
59nitrogen cycle metabolic process (GO:0071941)3.11606826
60aromatic amino acid family metabolic process (GO:0009072)3.04343018
61regulation of fibrinolysis (GO:0051917)3.04293490
62regulation of extracellular matrix organization (GO:1903053)3.03975965
63protein-lipid complex remodeling (GO:0034368)3.03851617
64macromolecular complex remodeling (GO:0034367)3.03851617
65plasma lipoprotein particle remodeling (GO:0034369)3.03851617
66cholesterol efflux (GO:0033344)3.01844381
67triglyceride homeostasis (GO:0070328)3.01759978
68acylglycerol homeostasis (GO:0055090)3.01759978
69midgut development (GO:0007494)2.98697295
70bile acid metabolic process (GO:0008206)2.97623704
71regulation of complement activation (GO:0030449)2.97246547
72regulation of cholesterol esterification (GO:0010872)2.96869289
73nicotinamide nucleotide biosynthetic process (GO:0019359)2.95412648
74pyridine nucleotide biosynthetic process (GO:0019363)2.95412648
75linoleic acid metabolic process (GO:0043651)2.94372777
76negative regulation of fibrinolysis (GO:0051918)2.91449864
77cardiac ventricle formation (GO:0003211)2.90227933
78negative regulation of lipase activity (GO:0060192)2.90192533
79low-density lipoprotein particle remodeling (GO:0034374)2.89112158
80epoxygenase P450 pathway (GO:0019373)2.87520257
81very-low-density lipoprotein particle assembly (GO:0034379)2.86963970
82positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.83569729
83positive regulation of blood vessel endothelial cell migration (GO:0043536)2.83447670
84cell-substrate junction assembly (GO:0007044)2.82188580
85glucuronate metabolic process (GO:0019585)2.81019086
86uronic acid metabolic process (GO:0006063)2.81019086
87retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.80722582
88retina vasculature morphogenesis in camera-type eye (GO:0061299)2.76104535
89skin morphogenesis (GO:0043589)2.73724641
90negative regulation of protein activation cascade (GO:2000258)2.73581259
91regulation of bile acid biosynthetic process (GO:0070857)2.73501732
92lipoprotein metabolic process (GO:0042157)2.73443474
93positive regulation of protein localization to plasma membrane (GO:1903078)2.72993682
94regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.72638869
95amino-acid betaine metabolic process (GO:0006577)2.72470241
96mesenchymal-epithelial cell signaling (GO:0060638)2.72453387
97plasma lipoprotein particle assembly (GO:0034377)2.71783334
98positive regulation of lipid catabolic process (GO:0050996)2.71703365
99regulation of glucokinase activity (GO:0033131)2.71404666
100regulation of hexokinase activity (GO:1903299)2.71404666
101glyoxylate metabolic process (GO:0046487)2.71327628
102valine metabolic process (GO:0006573)2.71079975
103regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70827708
104coenzyme catabolic process (GO:0009109)2.70139470
105regulation of endothelial cell apoptotic process (GO:2000351)2.69360147
106imidazole-containing compound metabolic process (GO:0052803)2.64994075
107UDP-N-acetylglucosamine metabolic process (GO:0006047)2.63455479
108alpha-amino acid catabolic process (GO:1901606)2.63401487
109cardiac chamber formation (GO:0003207)2.63281257
110response to interferon-alpha (GO:0035455)2.62537402
111vesicle coating (GO:0006901)2.61168067
112plasma lipoprotein particle clearance (GO:0034381)2.60949292
113omega-hydroxylase P450 pathway (GO:0097267)2.58945345
114regulation of extracellular matrix disassembly (GO:0010715)2.57658561
115embryonic retina morphogenesis in camera-type eye (GO:0060059)2.56705126
116positive regulation of fatty acid oxidation (GO:0046321)2.56272915
117DNA integration (GO:0015074)2.55389304
118plasma lipoprotein particle organization (GO:0071827)2.54066324
119cell-substrate adherens junction assembly (GO:0007045)2.51606705
120focal adhesion assembly (GO:0048041)2.51606705
121specification of organ identity (GO:0010092)2.51365359
122regulation of sequestering of triglyceride (GO:0010889)2.50715139
123fibroblast migration (GO:0010761)2.49882682
124cholesterol homeostasis (GO:0042632)2.49032525
125positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.47856766
126proline biosynthetic process (GO:0006561)2.46963333
127positive regulation of interferon-alpha production (GO:0032727)2.46240975
128bile acid and bile salt transport (GO:0015721)2.45794750
129regulation of apoptotic cell clearance (GO:2000425)2.43625188
130intestinal cholesterol absorption (GO:0030299)2.43308928
131cell migration involved in gastrulation (GO:0042074)2.42562586
132blood coagulation, intrinsic pathway (GO:0007597)2.42071642
133exogenous drug catabolic process (GO:0042738)2.41983400
134negative regulation of chondrocyte differentiation (GO:0032331)2.41956147
135regulation of non-canonical Wnt signaling pathway (GO:2000050)2.41898996
136negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.41595601
137sterol homeostasis (GO:0055092)2.40922938
138negative regulation of keratinocyte proliferation (GO:0010839)2.38225854
139histone H3-K4 trimethylation (GO:0080182)2.37901223
140purine nucleotide transport (GO:0015865)2.37362793
141chondrocyte proliferation (GO:0035988)2.36673647
142negative regulation of complement activation (GO:0045916)2.36428896
143purine ribonucleotide transport (GO:0015868)2.35320540
144biotin metabolic process (GO:0006768)2.35227914
145regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.34968652
146sulfur amino acid catabolic process (GO:0000098)2.34440624
147replicative senescence (GO:0090399)2.33293440
148fibrinolysis (GO:0042730)2.32583127
149collagen fibril organization (GO:0030199)2.32375963
150negative regulation of lipid storage (GO:0010888)2.32079123
151semaphorin-plexin signaling pathway (GO:0071526)2.31583230
152arginine metabolic process (GO:0006525)2.30584885
153regulation of plasminogen activation (GO:0010755)2.30237091
154protein activation cascade (GO:0072376)2.30055390
155daunorubicin metabolic process (GO:0044597)2.29534389
156polyketide metabolic process (GO:0030638)2.29534389
157doxorubicin metabolic process (GO:0044598)2.29534389
158positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.29104741
159drug catabolic process (GO:0042737)2.28939365
160regulation of fibroblast migration (GO:0010762)2.27842275
161dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.26317451
162primary alcohol catabolic process (GO:0034310)2.22571433
163macroautophagy (GO:0016236)2.22489582
164response to growth hormone (GO:0060416)2.19502275
165positive regulation of ERBB signaling pathway (GO:1901186)2.19449183
166negative regulation of fatty acid transport (GO:2000192)2.19107484
167actin filament depolymerization (GO:0030042)2.17998326
168iron ion import (GO:0097286)2.17836947
169type B pancreatic cell proliferation (GO:0044342)2.16134149
170necroptotic process (GO:0070266)2.15814413
171vascular endothelial growth factor signaling pathway (GO:0038084)2.15706616
172adherens junction assembly (GO:0034333)2.15203882
173regulation of substrate adhesion-dependent cell spreading (GO:1900024)2.14954049
174proline metabolic process (GO:0006560)2.14842255
175regulation of integrin-mediated signaling pathway (GO:2001044)2.11978576
176retinal metabolic process (GO:0042574)2.11420957
177smooth muscle tissue development (GO:0048745)2.09591000
178regulation of establishment of protein localization to plasma membrane (GO:0090003)2.09354665
179ethanol oxidation (GO:0006069)2.09179820
180regulation of protein localization to plasma membrane (GO:1903076)2.08583626
181negative regulation of cell-matrix adhesion (GO:0001953)2.08046748
182lymphangiogenesis (GO:0001946)2.07952717
183negative regulation of stem cell proliferation (GO:2000647)2.07776479
184endodermal cell differentiation (GO:0035987)2.07425621
185glutamine family amino acid biosynthetic process (GO:0009084)2.07095468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse4.26540156
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.88773067
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.68545472
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.48878975
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.36977850
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.31857039
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.24236757
8* RXR_22158963_ChIP-Seq_LIVER_Mouse2.97449773
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.73153875
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.69399762
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61446497
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.58107809
13* LXR_22158963_ChIP-Seq_LIVER_Mouse2.57324109
14GBX2_23144817_ChIP-Seq_PC3_Human2.49448527
15CJUN_26792858_Chip-Seq_BT549_Human2.23614045
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.22093831
17* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.21834154
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17338246
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.13526273
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.12684340
21* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.11616347
22GATA1_22025678_ChIP-Seq_K562_Human2.11379251
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.10289041
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09200215
25CLOCK_20551151_ChIP-Seq_293T_Human2.08931677
26* SUZ12_27294783_Chip-Seq_NPCs_Mouse2.05418571
27* FLI1_27457419_Chip-Seq_LIVER_Mouse2.02688425
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.01560955
29* NFE2_27457419_Chip-Seq_LIVER_Mouse1.98152551
30* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.95596781
31BRD4_25478319_ChIP-Seq_HGPS_Human1.95330954
32AHR_22903824_ChIP-Seq_MCF-7_Human1.95168404
33* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.91399045
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.90756806
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.90655898
36CTNNB1_20460455_ChIP-Seq_HCT116_Human1.89696249
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89147135
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86742054
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.84009818
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.82234476
41* EZH2_27294783_Chip-Seq_NPCs_Mouse1.80762190
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.79669831
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.77898513
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.77664973
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.76510033
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73163086
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.71051209
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.70971784
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69168850
50ZNF263_19887448_ChIP-Seq_K562_Human1.67304139
51SOX2_20726797_ChIP-Seq_SW620_Human1.67199597
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66697381
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65803510
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.63165899
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.63165899
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62656854
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61683430
58TCF4_18268006_ChIP-ChIP_LS174T_Human1.58930742
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58181807
60* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.58128168
61CDX2_20551321_ChIP-Seq_CACO-2_Human1.57568458
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.56859768
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55274973
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55076280
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.54089271
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52921161
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.52676568
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.51712133
69* P53_22387025_ChIP-Seq_ESCs_Mouse1.50378866
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.50209090
71* E2F1_18555785_Chip-Seq_ESCs_Mouse1.49587531
72* NANOG_18555785_Chip-Seq_ESCs_Mouse1.49389793
73* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47907906
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46956122
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46157834
76* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.44729627
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41394717
78P300_19829295_ChIP-Seq_ESCs_Human1.40624797
79TP53_18474530_ChIP-ChIP_U2OS_Human1.39229376
80IRF8_21731497_ChIP-ChIP_J774_Mouse1.38514396
81* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38238418
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38191812
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38191812
84* STAT3_18555785_Chip-Seq_ESCs_Mouse1.37618874
85* OCT4_18555785_Chip-Seq_ESCs_Mouse1.37055494
86* P300_18555785_Chip-Seq_ESCs_Mouse1.36701311
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36610067
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36087754
89* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35518956
90FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.35243833
91* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.35232224
92SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34206770
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33542252
94SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32770560
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32246646
96* PU1_27457419_Chip-Seq_LIVER_Mouse1.30727426
97* CMYC_18555785_Chip-Seq_ESCs_Mouse1.29460774
98* NMYC_18555785_Chip-Seq_ESCs_Mouse1.29022373
99* TP63_23658742_ChIP-Seq_EP156T_Human1.28761505
100* FUS_26573619_Chip-Seq_HEK293_Human1.28116184
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28044518
102TP63_19390658_ChIP-ChIP_HaCaT_Human1.27903346
103* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.27848327
104JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27259032
105EWS_26573619_Chip-Seq_HEK293_Human1.26953864
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26856328
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25997629
108TP53_16413492_ChIP-PET_HCT116_Human1.25684189
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25678576
110* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.24915429
111* CRX_20693478_ChIP-Seq_RETINA_Mouse1.24677266
112* SOX2_18555785_Chip-Seq_ESCs_Mouse1.22649622
113HNF4A_19822575_ChIP-Seq_HepG2_Human1.22100174
114GATA4_25053715_ChIP-Seq_YYC3_Human1.21837294
115FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21170215
116* ZFX_18555785_Chip-Seq_ESCs_Mouse1.19214092
117GATA3_24758297_ChIP-Seq_MCF-7_Human1.18783738
118GATA2_21666600_ChIP-Seq_HMVEC_Human1.18513660
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18228972
120SMAD4_21799915_ChIP-Seq_A2780_Human1.15988245
121* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.15727324
122TAF15_26573619_Chip-Seq_HEK293_Human1.15104421
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14219963
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14056089
125STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13662721
126AR_21909140_ChIP-Seq_LNCAP_Human1.13089882
127TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12094917
128* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11897440
129IRF8_27001747_Chip-Seq_BMDM_Mouse1.11624853
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10979973
131TBX20_22328084_ChIP-Seq_HEART_Mouse1.10930905
132TBX20_22080862_ChIP-Seq_HEART_Mouse1.10930905
133* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.10772169
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10627935
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08788420
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08788420
137NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08183887
138* KLF4_18555785_Chip-Seq_ESCs_Mouse1.07760488
139* CTCF_18555785_Chip-Seq_ESCs_Mouse1.07306904
140RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06775847
141P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06535069
142JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05456656
143ER_23166858_ChIP-Seq_MCF-7_Human1.04650951
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03768096
145CDX2_22108803_ChIP-Seq_LS180_Human1.03722459
146* STAT3_23295773_ChIP-Seq_U87_Human1.02900002
147PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.02728346
148FOXA2_19822575_ChIP-Seq_HepG2_Human1.01760370
149ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01577415
150RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01195589
151SCL_19346495_ChIP-Seq_HPC-7_Human1.00658862
152NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00627805
153TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00486378
154WT1_19549856_ChIP-ChIP_CCG9911_Human1.00328361
155FOXA1_25552417_ChIP-Seq_VCAP_Human1.00312574
156IRF1_19129219_ChIP-ChIP_H3396_Human0.99980758
157* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99060873
158WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98441784
159TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97738146
160AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95791588
161* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94195432
162ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93939862
163NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93618250
164SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92613349

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.06918842
2MP0005360_urolithiasis4.27861415
3MP0005365_abnormal_bile_salt3.84230360
4MP0009697_abnormal_copulation3.62307380
5MP0003950_abnormal_plasma_membrane3.61748416
6MP0005085_abnormal_gallbladder_physiolo3.49630798
7MP0009780_abnormal_chondrocyte_physiolo3.49167394
8MP0002234_abnormal_pharynx_morphology3.24319740
9MP0000569_abnormal_digit_pigmentation3.12563887
10MP0003252_abnormal_bile_duct3.10629122
11MP0004272_abnormal_basement_membrane3.00899237
12MP0006054_spinal_hemorrhage2.76217002
13MP0000566_synostosis2.72822142
14MP0010234_abnormal_vibrissa_follicle2.50094743
15MP0008875_abnormal_xenobiotic_pharmacok2.36106924
16MP0003705_abnormal_hypodermis_morpholog2.29469078
17MP0005171_absent_coat_pigmentation2.10981691
18MP0000013_abnormal_adipose_tissue1.99267856
19MP0010329_abnormal_lipoprotein_level1.97014969
20MP0003941_abnormal_skin_development1.92114175
21MP0003566_abnormal_cell_adhesion1.91597926
22MP0008438_abnormal_cutaneous_collagen1.89243742
23MP0005023_abnormal_wound_healing1.87593042
24MP0002938_white_spotting1.87158251
25MP0005503_abnormal_tendon_morphology1.77627532
26MP0003868_abnormal_feces_composition1.76173249
27MP0001346_abnormal_lacrimal_gland1.66468212
28MP0000751_myopathy1.58532929
29MP0001835_abnormal_antigen_presentation1.58299535
30MP0002876_abnormal_thyroid_physiology1.55887670
31MP0000003_abnormal_adipose_tissue1.53989995
32MP0005666_abnormal_adipose_tissue1.53529140
33MP0005670_abnormal_white_adipose1.52069846
34MP0002138_abnormal_hepatobiliary_system1.48192366
35MP0005375_adipose_tissue_phenotype1.45405214
36MP0005408_hypopigmentation1.44389335
37MP0002254_reproductive_system_inflammat1.43984892
38MP0001666_abnormal_nutrient_absorption1.43818915
39MP0001661_extended_life_span1.43272963
40MP0005409_darkened_coat_color1.42773550
41MP0005647_abnormal_sex_gland1.42188871
42MP0001299_abnormal_eye_distance/1.38911511
43MP0003279_aneurysm1.38142617
44MP0004381_abnormal_hair_follicle1.36053398
45MP0002896_abnormal_bone_mineralization1.34249653
46MP0004233_abnormal_muscle_weight1.29327478
47MP0003195_calcinosis1.27603997
48MP0004264_abnormal_extraembryonic_tissu1.27127944
49MP0005332_abnormal_amino_acid1.26942731
50MP0001764_abnormal_homeostasis1.25422761
51MP0005058_abnormal_lysosome_morphology1.25313971
52MP0005248_abnormal_Harderian_gland1.25112958
53MP0000371_diluted_coat_color1.24644011
54MP0003385_abnormal_body_wall1.22987599
55MP0010352_gastrointestinal_tract_polyps1.22254848
56MP0000372_irregular_coat_pigmentation1.21398414
57MP0005623_abnormal_meninges_morphology1.20185668
58MP0001188_hyperpigmentation1.20037431
59MP0005083_abnormal_biliary_tract1.19523394
60MP0002089_abnormal_postnatal_growth/wei1.18981685
61MP0000733_abnormal_muscle_development1.18871209
62MP0009764_decreased_sensitivity_to1.17490909
63MP0005379_endocrine/exocrine_gland_phen1.17055650
64MP0003787_abnormal_imprinting1.16236194
65MP0000427_abnormal_hair_cycle1.15696393
66MP0002108_abnormal_muscle_morphology1.15201418
67MP0003091_abnormal_cell_migration1.14241535
68MP0005075_abnormal_melanosome_morpholog1.13517069
69MP0010678_abnormal_skin_adnexa1.13009344
70MP0004019_abnormal_vitamin_homeostasis1.11407556
71MP0001879_abnormal_lymphatic_vessel1.10391558
72MP0000383_abnormal_hair_follicle1.09300867
73MP0002638_abnormal_pupillary_reflex1.06642202
74MP0000609_abnormal_liver_physiology1.04350808
75MP0009763_increased_sensitivity_to1.02491603
76MP0000767_abnormal_smooth_muscle1.01461031
77MP0002249_abnormal_larynx_morphology1.01224061
78MP0005367_renal/urinary_system_phenotyp1.01010160
79MP0000516_abnormal_urinary_system1.01010160
80MP0002095_abnormal_skin_pigmentation0.98458993
81MP0002060_abnormal_skin_morphology0.97943467
82MP0008007_abnormal_cellular_replicative0.97861899
83MP0001958_emphysema0.97710279
84MP0000015_abnormal_ear_pigmentation0.97377158
85MP0000749_muscle_degeneration0.97312107
86MP0010368_abnormal_lymphatic_system0.97145241
87MP0002118_abnormal_lipid_homeostasis0.96038323
88MP0008775_abnormal_heart_ventricle0.94209745
89MP0010030_abnormal_orbit_morphology0.92338117
90MP0002396_abnormal_hematopoietic_system0.92249544
91MP0002166_altered_tumor_susceptibility0.92177237
92MP0001186_pigmentation_phenotype0.92011277
93MP0005220_abnormal_exocrine_pancreas0.91959650
94MP0004087_abnormal_muscle_fiber0.91551161
95MP0001324_abnormal_eye_pigmentation0.91494302
96MP0003183_abnormal_peptide_metabolism0.91405185
97MP0009250_abnormal_appendicular_skeleto0.90853125
98MP0000534_abnormal_ureter_morphology0.90451837
99MP0005164_abnormal_response_to0.90012659
100MP0002177_abnormal_outer_ear0.89697834
101MP0000762_abnormal_tongue_morphology0.88725636
102MP0001873_stomach_inflammation0.88177108
103MP0002075_abnormal_coat/hair_pigmentati0.87930608
104MP0009384_cardiac_valve_regurgitation0.87428090
105MP0004134_abnormal_chest_morphology0.86446295
106MP0004782_abnormal_surfactant_physiolog0.85573029
107MP0003115_abnormal_respiratory_system0.85418057
108MP0003943_abnormal_hepatobiliary_system0.85410768
109MP0002932_abnormal_joint_morphology0.85396488
110MP0002282_abnormal_trachea_morphology0.85295017
111MP0001177_atelectasis0.85004154
112MP0008057_abnormal_DNA_replication0.84000942
113MP0005275_abnormal_skin_tensile0.82890678
114MP0002109_abnormal_limb_morphology0.82734678
115MP0002971_abnormal_brown_adipose0.82445565
116MP0009785_altered_susceptibility_to0.82441701
117MP0005187_abnormal_penis_morphology0.82072210
118MP0009840_abnormal_foam_cell0.81333684
119MP0002419_abnormal_innate_immunity0.80165223
120MP0005174_abnormal_tail_pigmentation0.79938821
121MP0004084_abnormal_cardiac_muscle0.79428003
122MP0001119_abnormal_female_reproductive0.79015758
123MP0002928_abnormal_bile_duct0.78794053
124MP0000579_abnormal_nail_morphology0.78793168
125MP0003011_delayed_dark_adaptation0.78681498
126MP0000627_abnormal_mammary_gland0.78571675
127MP0004510_myositis0.78527992
128MP0005197_abnormal_uvea_morphology0.78500778
129MP0003191_abnormal_cellular_cholesterol0.78385143
130MP0002277_abnormal_respiratory_mucosa0.78380286
131MP0003172_abnormal_lysosome_physiology0.78288696
132MP0002163_abnormal_gland_morphology0.77977514
133MP0005508_abnormal_skeleton_morphology0.77856253
134MP0001853_heart_inflammation0.77492361
135MP0005257_abnormal_intraocular_pressure0.77227616
136MP0003935_abnormal_craniofacial_develop0.77148677
137MP0005395_other_phenotype0.76960447
138MP0004130_abnormal_muscle_cell0.76819301
139MP0006138_congestive_heart_failure0.76777135
140MP0002132_abnormal_respiratory_system0.76284417
141MP0000538_abnormal_urinary_bladder0.76054332
142MP0005334_abnormal_fat_pad0.76036332
143MP0005330_cardiomyopathy0.75840300
144MP0002115_abnormal_skeleton_extremities0.75601560
145MP0002168_other_aberrant_phenotype0.75297514
146MP0001614_abnormal_blood_vessel0.73843920
147MP0003942_abnormal_urinary_system0.73361938
148MP0008058_abnormal_DNA_repair0.72706012
149MP0000537_abnormal_urethra_morphology0.72456062
150MP0002909_abnormal_adrenal_gland0.72337558
151MP0003937_abnormal_limbs/digits/tail_de0.71633835
152MP0005319_abnormal_enzyme/_coenzyme0.71547872
153MP0002006_tumorigenesis0.71224065
154MP0001243_abnormal_dermal_layer0.70784894
155MP0000598_abnormal_liver_morphology0.70707235
156MP0002128_abnormal_blood_circulation0.69986615
157MP0002295_abnormal_pulmonary_circulatio0.69741314
158MP0000432_abnormal_head_morphology0.69452108
159MP0002269_muscular_atrophy0.68575197
160MP0005387_immune_system_phenotype0.68067546
161MP0001790_abnormal_immune_system0.68067546
162MP0000163_abnormal_cartilage_morphology0.67948983
163MP0005464_abnormal_platelet_physiology0.67652678

Predicted human phenotypes

RankGene SetZ-score
1Glucose intolerance (HP:0000833)4.54358983
2Prolonged partial thromboplastin time (HP:0003645)4.27874697
3Protrusio acetabuli (HP:0003179)3.89609756
4Intrahepatic cholestasis (HP:0001406)3.69145475
5Chronic hepatic failure (HP:0100626)3.64458720
6Renal cortical cysts (HP:0000803)3.63067118
7Hypoplasia of the iris (HP:0007676)3.58882517
8Joint hemorrhage (HP:0005261)3.58227326
9Premature rupture of membranes (HP:0001788)3.51218881
10Cervical subluxation (HP:0003308)3.49518265
11Conjugated hyperbilirubinemia (HP:0002908)3.45756254
12Abnormal glucose tolerance (HP:0001952)3.45544018
13Epidermoid cyst (HP:0200040)3.44532440
14Enlarged kidneys (HP:0000105)3.37127281
15Aortic dissection (HP:0002647)3.25005900
16Autoimmune thrombocytopenia (HP:0001973)3.21496784
17Vascular tortuosity (HP:0004948)3.20001572
18Arterial tortuosity (HP:0005116)3.19031970
19Enlarged epiphyses (HP:0010580)3.18821403
20Aortic aneurysm (HP:0004942)3.13646325
21Abnormality of methionine metabolism (HP:0010901)3.11972628
22Insulin-resistant diabetes mellitus (HP:0000831)3.08977989
23Abnormality of incisor morphology (HP:0011063)3.06032731
24Deep venous thrombosis (HP:0002625)3.05315567
25Atrophic scars (HP:0001075)3.05175357
26Sparse lateral eyebrow (HP:0005338)3.01858525
27Abnormality of aromatic amino acid family metabolism (HP:0004338)2.99387000
28Abnormality of the fingertips (HP:0001211)2.97372192
29Abnormality of monocarboxylic acid metabolism (HP:0010996)2.92976209
30Abnormality of glutamine family amino acid metabolism (HP:0010902)2.89217706
31Hyperglycemia (HP:0003074)2.78463874
32Chin dimple (HP:0010751)2.73528302
33Hypobetalipoproteinemia (HP:0003563)2.71645621
34Autoimmune hemolytic anemia (HP:0001890)2.70211003
35Abnormality of aspartate family amino acid metabolism (HP:0010899)2.68778360
36Premature skin wrinkling (HP:0100678)2.68680299
37Cardiovascular calcification (HP:0011915)2.66253839
38Xanthomatosis (HP:0000991)2.65782411
39Hepatoblastoma (HP:0002884)2.64352951
40Hypoglycemic coma (HP:0001325)2.61927488
41Abnormality of pyrimidine metabolism (HP:0004353)2.60612181
42Abnormality of sulfur amino acid metabolism (HP:0004339)2.60572995
43Abnormality of the renal cortex (HP:0011035)2.60279504
44Neonatal hypoglycemia (HP:0001998)2.59013010
45Abnormality of complement system (HP:0005339)2.57123187
46Tubulointerstitial nephritis (HP:0001970)2.54471601
47Gingival bleeding (HP:0000225)2.53023681
48Abnormality of the common coagulation pathway (HP:0010990)2.51263428
49Hyperlipoproteinemia (HP:0010980)2.49433820
50Prostate neoplasm (HP:0100787)2.49211251
51Shallow orbits (HP:0000586)2.47193209
52Abnormality of carpal bone ossification (HP:0006257)2.41285855
53Alveolar cell carcinoma (HP:0006519)2.39385472
54Neonatal short-limb short stature (HP:0008921)2.39134562
55Anterior segment dysgenesis (HP:0007700)2.35751237
56Vascular calcification (HP:0004934)2.32627943
57Hydroxyprolinuria (HP:0003080)2.31648587
58Abnormality of proline metabolism (HP:0010907)2.31648587
59Hypolipoproteinemia (HP:0010981)2.30481259
60Syringomyelia (HP:0003396)2.30032812
61Spinal cord lesions (HP:0100561)2.30032812
62Hypoalphalipoproteinemia (HP:0003233)2.28901526
63Fair hair (HP:0002286)2.28036701
64Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.26028539
65Complement deficiency (HP:0004431)2.24235596
66Abnormality of the intrinsic pathway (HP:0010989)2.23514085
67Pigmentary retinal degeneration (HP:0001146)2.21877349
68Hypoglycemic seizures (HP:0002173)2.21176702
69Opisthotonus (HP:0002179)2.19440494
70Chronic diarrhea (HP:0002028)2.18691751
71Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18670879
72Insulin resistance (HP:0000855)2.18347119
73Abnormal biliary tract physiology (HP:0012439)2.18108669
74Bile duct proliferation (HP:0001408)2.18108669
75Cerebral aneurysm (HP:0004944)2.18083693
76Short nail (HP:0001799)2.16725843
77Abnormality of homocysteine metabolism (HP:0010919)2.15513334
78Homocystinuria (HP:0002156)2.15513334
79Chromsome breakage (HP:0040012)2.14797022
80Neoplasm of the tracheobronchial system (HP:0100552)2.12168324
81Blue sclerae (HP:0000592)2.11321755
82Glomerulonephritis (HP:0000099)2.11129092
83Dry hair (HP:0011359)2.10720414
84Striae distensae (HP:0001065)2.09629658
85Hypercholesterolemia (HP:0003124)2.09082642
86Mildly elevated creatine phosphokinase (HP:0008180)2.08934514
87Flat acetabular roof (HP:0003180)2.08748795
88Abnormal ossification of hand bones (HP:0005921)2.07500359
89Spondylolisthesis (HP:0003302)2.06623554
90Abnormal hand bone ossification (HP:0010660)2.05514948
91Ovoid vertebral bodies (HP:0003300)2.05264574
92White forelock (HP:0002211)2.05013599
93Thin bony cortex (HP:0002753)2.04932197
94Fat malabsorption (HP:0002630)2.03809834
95Lip pit (HP:0100267)2.03481992
96Joint laxity (HP:0001388)2.02278338
97Aneurysm (HP:0002617)2.00675118
98Wormian bones (HP:0002645)2.00520204
99Advanced eruption of teeth (HP:0006288)2.00024675
100Tibial bowing (HP:0002982)2.00017282
101Right ventricular cardiomyopathy (HP:0011663)1.99477490
102Portal hypertension (HP:0001409)1.97337146
103Mesomelia (HP:0003027)1.96093010
104Bell-shaped thorax (HP:0001591)1.95686053
105Abnormality of the columella (HP:0009929)1.95600929
106Generalized aminoaciduria (HP:0002909)1.95470289
107Soft skin (HP:0000977)1.94532212
108Popliteal pterygium (HP:0009756)1.94267563
109Abnormality of the anterior chamber (HP:0000593)1.93588637
110Aortic regurgitation (HP:0001659)1.92492857
111Myocardial infarction (HP:0001658)1.91849876
112Follicular hyperkeratosis (HP:0007502)1.90766208
113Submucous cleft hard palate (HP:0000176)1.90094038
114Abnormality of the parietal bone (HP:0002696)1.88893420
115Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88876291
116Ankle contracture (HP:0006466)1.88742107
117Ectopic kidney (HP:0000086)1.88614725
118Fragile skin (HP:0001030)1.87599537
119Protruding ear (HP:0000411)1.87208063
120Protruding tongue (HP:0010808)1.86581203
121Abnormality of serum amino acid levels (HP:0003112)1.86385115
122Midline defect of the nose (HP:0004122)1.86127122
123Abnormality of fatty-acid metabolism (HP:0004359)1.85834404
124Abnormality of the hepatic vasculature (HP:0006707)1.83118886
125Neoplasm of the liver (HP:0002896)1.82885713
126Hyperglycinuria (HP:0003108)1.82376788
127Hypodontia (HP:0000668)1.82340000
128Abnormality of the incisor (HP:0000676)1.82128964
129Lymphangioma (HP:0100764)1.81483199
130Pulmonary artery stenosis (HP:0004415)1.81442728
131Depressed nasal tip (HP:0000437)1.80328305
132Focal segmental glomerulosclerosis (HP:0000097)1.80045604
133Blue irides (HP:0000635)1.79973146
134Abnormality of dentin (HP:0010299)1.79873851
135Patchy hypopigmentation of hair (HP:0011365)1.79198724
136Symptomatic seizures (HP:0011145)1.78660165
137Diastasis recti (HP:0001540)1.78473087
138Reduced subcutaneous adipose tissue (HP:0003758)1.77651282
139Congenital sensorineural hearing impairment (HP:0008527)1.76908067
140Abnormality of the nasal septum (HP:0000419)1.76440469
141Osteolytic defects of the phalanges of the hand (HP:0009771)1.75253462
142Osteolytic defects of the hand bones (HP:0009699)1.75253462
143Ectopia lentis (HP:0001083)1.74616733
144Menorrhagia (HP:0000132)1.74481827
145Proximal tubulopathy (HP:0000114)1.74406337
146Deep philtrum (HP:0002002)1.74101363
147Natal tooth (HP:0000695)1.74022020
148Abnormality of the prostate (HP:0008775)1.73836761
149Narrow palate (HP:0000189)1.73289587
150Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72341943
151Limited hip movement (HP:0008800)1.71586859
152Bladder diverticulum (HP:0000015)1.71210036
153Abnormality of the ischium (HP:0003174)1.71102541
154Abnormality of nucleobase metabolism (HP:0010932)1.70716609
155Urethral obstruction (HP:0000796)1.70403587
156Generalized hypopigmentation of hair (HP:0011358)1.68842029
157Urinary glycosaminoglycan excretion (HP:0003541)1.68689341
158Mucopolysacchariduria (HP:0008155)1.68689341
159Vitreoretinal degeneration (HP:0000655)1.68683925
160True hermaphroditism (HP:0010459)1.68617061
161Abnormality of the neuromuscular junction (HP:0003398)1.68567110
162Fatigable weakness (HP:0003473)1.68567110
163Recurrent gram-negative bacterial infections (HP:0005420)1.68524185
164Abnormality of the acetabulum (HP:0003170)1.68369172
165Chorioretinal atrophy (HP:0000533)1.67483571
166Myotonia (HP:0002486)1.66166705
167Ectropion (HP:0000656)1.65346668
168Asymmetry of the thorax (HP:0001555)1.64924237
169Abnormal delivery (HP:0001787)1.64532094
170Nephritis (HP:0000123)1.64439887
171Mitral stenosis (HP:0001718)1.64185831
172Absent frontal sinuses (HP:0002688)1.64142318
173Gowers sign (HP:0003391)1.64139212
174Congenital hepatic fibrosis (HP:0002612)1.63225687
175Skin nodule (HP:0200036)1.62441826
176Dilatation of the ascending aorta (HP:0005111)1.62120485
177Rhizomelia (HP:0008905)1.61905685
178Ulnar bowing (HP:0003031)1.61092859
179Decreased lacrimation (HP:0000633)1.60846026
180Asymmetric septal hypertrophy (HP:0001670)1.60344604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.24301658
2MAP3K143.15772762
3PTK23.07878117
4ZAK2.99534650
5CASK2.96555911
6EPHA22.66753365
7INSRR2.65997882
8ERBB32.55604928
9SIK12.54077923
10MAP3K62.45107399
11IRAK32.39969046
12BRD42.37150278
13YES11.99731860
14SRPK11.97294502
15CAMK1D1.94647817
16LATS11.94597434
17RET1.86937626
18EPHA31.86482016
19AKT31.81722356
20IRAK41.80402000
21EIF2AK21.76652040
22PIK3CG1.75242997
23NUAK11.72502961
24FER1.65729647
25SGK21.60333249
26FRK1.57791479
27SIK31.52461935
28RIPK11.52451173
29FGFR31.50840674
30FGFR41.50671718
31NEK91.50493145
32TXK1.41390692
33MKNK21.35645823
34CHUK1.31788229
35PBK1.30954763
36LIMK11.29696082
37IRAK11.29139262
38KIT1.27524402
39STK38L1.25404335
40MOS1.25095080
41JAK11.24418853
42CAMK1G1.24232771
43CAMKK21.21274299
44SGK31.19777050
45CDK121.18271779
46MKNK11.17486095
47MYLK1.17256171
48PIK3CA1.17102079
49TIE11.17028647
50TYK21.16396443
51TTN1.15882713
52TRIB31.15438401
53TNIK1.14899244
54EPHB21.14447941
55BRSK21.13826015
56IKBKE1.08816266
57TEC1.07819607
58TAOK31.06654808
59IKBKB1.02062583
60FGFR21.01652829
61OBSCN1.01138181
62PRKAA20.98094621
63ICK0.96535858
64EEF2K0.94111270
65PNCK0.93967667
66JAK30.93713569
67TESK10.92946241
68MST1R0.91795958
69LMTK20.89862049
70TAOK20.88686452
71STK30.87798663
72BMPR20.87363096
73STK40.87255300
74MUSK0.86951358
75PAK40.86544833
76PRKD30.85983861
77PLK40.85527180
78MAPKAPK30.84922274
79TRPM70.83996358
80STK160.83606129
81STK100.83284109
82FLT30.83261240
83NEK60.82531801
84MAPK150.80695109
85MAP2K60.80485247
86ATR0.79945927
87TBK10.78538685
88ROCK10.78136051
89EPHB10.74061469
90SGK2230.73818582
91SGK4940.73818582
92LATS20.71867904
93PDGFRA0.71705502
94MTOR0.70703117
95ERBB40.69981414
96CDK30.69772122
97MAP2K30.68303513
98NLK0.66997044
99PKN20.66970087
100MAP3K130.66402110
101NTRK10.65863995
102PAK30.64735222
103CDK60.64209947
104IRAK20.64179455
105BCKDK0.63687430
106MAPK70.63397890
107MST40.61383694
108PRKCE0.61210765
109STK380.60750274
110OXSR10.60426301
111MAP2K70.59904605
112PAK20.58063199
113PRKD10.57173543
114PTK2B0.57158115
115PTK60.56926806
116CSF1R0.56122642
117GRK70.55473215
118FGFR10.55192979
119ROCK20.54986581
120STK390.54649576
121CLK10.54188112
122RPS6KB10.54166835
123MAP3K20.53973535
124TGFBR20.53893387
125GRK10.52896356
126PRKD20.52645018
127STK240.52088511
128IGF1R0.51499509
129CAMK40.51326869
130BMPR1B0.49667764
131PRKAA10.49011382
132MAP2K40.47312191
133DMPK0.45612710
134PDPK10.45564460
135ATM0.45247306
136INSR0.44569263
137MAP4K20.42170933
138PDGFRB0.42042866
139EPHA40.41708130
140MAPK120.41667494
141CDK80.41429207
142ILK0.39034858
143MAP2K10.38949514
144SGK10.37586183
145MAP3K70.36239708
146MAPK110.36199943
147PLK20.35429333
148GSK3A0.34311561
149CDC42BPA0.34284770
150BTK0.33959835
151PRKG10.33949084
152ERBB20.33796481
153MET0.33745984
154BCR0.33511929
155AKT10.33389989
156DDR20.33000294
157ADRBK10.31784998
158BRSK10.28870064
159PRKCI0.27918727

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.62469299
2Vitamin B6 metabolism_Homo sapiens_hsa007503.17620711
3Complement and coagulation cascades_Homo sapiens_hsa046102.60743719
4Tryptophan metabolism_Homo sapiens_hsa003802.45515275
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.45130101
6Fatty acid degradation_Homo sapiens_hsa000712.31260294
7Steroid hormone biosynthesis_Homo sapiens_hsa001402.29862575
8Nitrogen metabolism_Homo sapiens_hsa009102.25160345
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.23783371
10Caffeine metabolism_Homo sapiens_hsa002322.23750931
11Peroxisome_Homo sapiens_hsa041462.11946907
12Lysine degradation_Homo sapiens_hsa003102.09020194
13Retinol metabolism_Homo sapiens_hsa008302.08004719
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00677977
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96486805
16Staphylococcus aureus infection_Homo sapiens_hsa051501.96122779
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89627997
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88127059
19beta-Alanine metabolism_Homo sapiens_hsa004101.87891696
20Histidine metabolism_Homo sapiens_hsa003401.84924424
21Arginine biosynthesis_Homo sapiens_hsa002201.78140352
22Propanoate metabolism_Homo sapiens_hsa006401.74729974
23Chemical carcinogenesis_Homo sapiens_hsa052041.73469909
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70226288
25PPAR signaling pathway_Homo sapiens_hsa033201.70030740
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.68717559
27Fatty acid metabolism_Homo sapiens_hsa012121.64967827
28One carbon pool by folate_Homo sapiens_hsa006701.62759579
29ABC transporters_Homo sapiens_hsa020101.62331052
30Pentose phosphate pathway_Homo sapiens_hsa000301.61193950
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59803310
32Steroid biosynthesis_Homo sapiens_hsa001001.53344375
33Focal adhesion_Homo sapiens_hsa045101.52892229
34Sulfur metabolism_Homo sapiens_hsa009201.46168870
35Vitamin digestion and absorption_Homo sapiens_hsa049771.45920666
36Starch and sucrose metabolism_Homo sapiens_hsa005001.43156457
37Tyrosine metabolism_Homo sapiens_hsa003501.42897160
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41033813
39Fatty acid elongation_Homo sapiens_hsa000621.37138225
40Phenylalanine metabolism_Homo sapiens_hsa003601.36483198
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35053192
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31597631
43Proteoglycans in cancer_Homo sapiens_hsa052051.29205403
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.29165645
45Selenocompound metabolism_Homo sapiens_hsa004501.27455617
46Butanoate metabolism_Homo sapiens_hsa006501.27255064
47Other glycan degradation_Homo sapiens_hsa005111.25228749
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.19794510
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.14658023
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12050089
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10961616
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04032065
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02394998
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01122048
55Amoebiasis_Homo sapiens_hsa051460.99105719
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97690300
57Sphingolipid metabolism_Homo sapiens_hsa006000.94923707
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93203809
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.93192624
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92739800
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88399343
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84423314
63Protein digestion and absorption_Homo sapiens_hsa049740.83587210
64Herpes simplex infection_Homo sapiens_hsa051680.82210239
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81236269
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81196194
67Folate biosynthesis_Homo sapiens_hsa007900.80498783
68Measles_Homo sapiens_hsa051620.79610895
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79601274
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.78857535
71AMPK signaling pathway_Homo sapiens_hsa041520.78554301
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77867235
73mTOR signaling pathway_Homo sapiens_hsa041500.77309499
74Fanconi anemia pathway_Homo sapiens_hsa034600.77100635
75ECM-receptor interaction_Homo sapiens_hsa045120.76846839
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76407606
77Dilated cardiomyopathy_Homo sapiens_hsa054140.76274064
78Allograft rejection_Homo sapiens_hsa053300.73830045
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70898979
80Influenza A_Homo sapiens_hsa051640.70468746
81FoxO signaling pathway_Homo sapiens_hsa040680.69982281
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69520115
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69027980
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68366271
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67297027
86Fructose and mannose metabolism_Homo sapiens_hsa000510.67290940
87Asthma_Homo sapiens_hsa053100.67213621
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.66556550
89Linoleic acid metabolism_Homo sapiens_hsa005910.66401925
90Renin-angiotensin system_Homo sapiens_hsa046140.65438377
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64924039
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64052292
93Endometrial cancer_Homo sapiens_hsa052130.62238783
94Pancreatic cancer_Homo sapiens_hsa052120.61305216
95Thyroid hormone synthesis_Homo sapiens_hsa049180.57329280
96Malaria_Homo sapiens_hsa051440.56594413
97Bile secretion_Homo sapiens_hsa049760.56488456
98Mineral absorption_Homo sapiens_hsa049780.56319417
99Tight junction_Homo sapiens_hsa045300.56313422
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56198912
101Chronic myeloid leukemia_Homo sapiens_hsa052200.55648642
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53178623
103Carbon metabolism_Homo sapiens_hsa012000.52778548
104Fat digestion and absorption_Homo sapiens_hsa049750.51370313
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51101548
106Renal cell carcinoma_Homo sapiens_hsa052110.50946748
107Choline metabolism in cancer_Homo sapiens_hsa052310.50658357
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.49746865
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49695383
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49421716
111Fatty acid biosynthesis_Homo sapiens_hsa000610.49362369
112Insulin signaling pathway_Homo sapiens_hsa049100.48993634
113Prolactin signaling pathway_Homo sapiens_hsa049170.48972866
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48836522
115Glucagon signaling pathway_Homo sapiens_hsa049220.46590137
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.46517355
117Dorso-ventral axis formation_Homo sapiens_hsa043200.46438480
118Non-homologous end-joining_Homo sapiens_hsa034500.46394409
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45583942
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45317677
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44206936
122Melanoma_Homo sapiens_hsa052180.44102344
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.43177021
124Hippo signaling pathway_Homo sapiens_hsa043900.42751333
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42692767
126Arachidonic acid metabolism_Homo sapiens_hsa005900.42291097
127Glioma_Homo sapiens_hsa052140.42097325
128Ovarian steroidogenesis_Homo sapiens_hsa049130.40667476
129African trypanosomiasis_Homo sapiens_hsa051430.39116272
130Hepatitis C_Homo sapiens_hsa051600.38948918
131Insulin resistance_Homo sapiens_hsa049310.38789271
132Pyruvate metabolism_Homo sapiens_hsa006200.38603451
133Graft-versus-host disease_Homo sapiens_hsa053320.37657316
134Glycerolipid metabolism_Homo sapiens_hsa005610.36006889
135Hematopoietic cell lineage_Homo sapiens_hsa046400.35683585
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.34967861
137TNF signaling pathway_Homo sapiens_hsa046680.32587061
138Legionellosis_Homo sapiens_hsa051340.30484773
139Small cell lung cancer_Homo sapiens_hsa052220.30261654
140Arginine and proline metabolism_Homo sapiens_hsa003300.30183311
141Leishmaniasis_Homo sapiens_hsa051400.28909170
142Homologous recombination_Homo sapiens_hsa034400.28675206
143Galactose metabolism_Homo sapiens_hsa000520.26424720
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.26226252
145Metabolic pathways_Homo sapiens_hsa011000.26054831
146Autoimmune thyroid disease_Homo sapiens_hsa053200.25991944
147Adherens junction_Homo sapiens_hsa045200.24539204
148Basal cell carcinoma_Homo sapiens_hsa052170.24332805
149MicroRNAs in cancer_Homo sapiens_hsa052060.22780682
150Systemic lupus erythematosus_Homo sapiens_hsa053220.21919099
151Circadian rhythm_Homo sapiens_hsa047100.21489491
152Prostate cancer_Homo sapiens_hsa052150.21285611

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