ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	respiratory chain complex IV assembly (GO:0008535)	6.09627841
2	DNA deamination (GO:0045006)	5.29660348
3	cytochrome complex assembly (GO:0017004)	5.11968426
4	response to pheromone (GO:0019236)	4.80544460
5	platelet dense granule organization (GO:0060155)	4.60665234
6	cellular ketone body metabolic process (GO:0046950)	4.57114973
7	water-soluble vitamin biosynthetic process (GO:0042364)	4.50766201
8	signal peptide processing (GO:0006465)	4.50578288
9	negative regulation of execution phase of apoptosis (GO:1900118)	4.43049860
10	L-alpha-amino acid transmembrane transport (GO:1902475)	4.11153111
11	ketone body metabolic process (GO:1902224)	4.00561271
12	positive regulation of histone H3-K4 methylation (GO:0051571)	3.99191508
13	endocrine pancreas development (GO:0031018)	3.89330268
14	adaptation of signaling pathway (GO:0023058)	3.70360316
15	prenylation (GO:0097354)	3.54428912
16	protein prenylation (GO:0018342)	3.54428912
17	single strand break repair (GO:0000012)	3.47212305
18	negative regulation of acute inflammatory response (GO:0002674)	3.46740411
19	rRNA methylation (GO:0031167)	3.45365165
20	cytidine deamination (GO:0009972)	3.42646428
21	cytidine metabolic process (GO:0046087)	3.42646428
22	cytidine catabolic process (GO:0006216)	3.42646428
23	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.41395343
24	rRNA modification (GO:0000154)	3.40870205
25	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.39412430
26	protein complex biogenesis (GO:0070271)	3.35643019
27	insulin secretion (GO:0030073)	3.33226315
28	pteridine-containing compound biosynthetic process (GO:0042559)	3.26376165
29	xenobiotic catabolic process (GO:0042178)	3.24311898
30	positive regulation of calcium ion import (GO:0090280)	3.22842616
31	positive regulation of cAMP-mediated signaling (GO:0043950)	3.18867733
32	branched-chain amino acid catabolic process (GO:0009083)	3.13514516
33	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.13310477
34	mitochondrial respiratory chain complex assembly (GO:0033108)	3.08040971
35	adenosine metabolic process (GO:0046085)	3.01033831
36	coenzyme catabolic process (GO:0009109)	2.98868319
37	regulation of glucokinase activity (GO:0033131)	2.96519089
38	regulation of hexokinase activity (GO:1903299)	2.96519089
39	regulation of helicase activity (GO:0051095)	2.96057996
40	positive regulation of insulin secretion (GO:0032024)	2.95712640
41	glucosamine-containing compound catabolic process (GO:1901072)	2.95315237
42	indolalkylamine metabolic process (GO:0006586)	2.94389424
43	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.92943208
44	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.92943208
45	lactate metabolic process (GO:0006089)	2.88118680
46	folic acid-containing compound biosynthetic process (GO:0009396)	2.83368787
47	positive regulation of peptide hormone secretion (GO:0090277)	2.79211124
48	endosome to pigment granule transport (GO:0043485)	2.77690933
49	endosome to melanosome transport (GO:0035646)	2.77690933
50	positive regulation of TOR signaling (GO:0032008)	2.76057990
51	indole-containing compound catabolic process (GO:0042436)	2.75131794
52	indolalkylamine catabolic process (GO:0046218)	2.75131794
53	tryptophan catabolic process (GO:0006569)	2.75131794
54	negative regulation of neurological system process (GO:0031645)	2.74395970
55	tryptophan metabolic process (GO:0006568)	2.72103783
56	epithelial cell fate commitment (GO:0072148)	2.71813159
57	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.71072017
58	detection of calcium ion (GO:0005513)	2.70593102
59	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.68271542
60	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.68271542
61	cellular biogenic amine catabolic process (GO:0042402)	2.66998036
62	amine catabolic process (GO:0009310)	2.66998036
63	positive regulation of prostaglandin secretion (GO:0032308)	2.66448377
64	positive regulation of peptide secretion (GO:0002793)	2.65043441
65	eosinophil chemotaxis (GO:0048245)	2.64782649
66	kidney morphogenesis (GO:0060993)	2.58862846
67	positive regulation of glycolytic process (GO:0045821)	2.58617341
68	nephron tubule morphogenesis (GO:0072078)	2.57945134
69	nephron epithelium morphogenesis (GO:0072088)	2.57945134
70	detection of light stimulus involved in sensory perception (GO:0050962)	2.57156812
71	detection of light stimulus involved in visual perception (GO:0050908)	2.57156812
72	positive regulation of response to nutrient levels (GO:0032109)	2.57046242
73	positive regulation of response to extracellular stimulus (GO:0032106)	2.57046242
74	neuromuscular process controlling posture (GO:0050884)	2.56620327
75	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.54318986
76	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.54318986
77	isotype switching (GO:0045190)	2.54318986
78	aromatic amino acid family catabolic process (GO:0009074)	2.53706071
79	positive regulation of macroautophagy (GO:0016239)	2.53497017
80	nitric oxide mediated signal transduction (GO:0007263)	2.51798736
81	acrosome reaction (GO:0007340)	2.50740857
82	electron transport chain (GO:0022900)	2.47752792
83	nodal signaling pathway (GO:0038092)	2.47034303
84	inositol phosphate dephosphorylation (GO:0046855)	2.46457364
85	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.46457364
86	respiratory electron transport chain (GO:0022904)	2.42341141
87	glycerophospholipid catabolic process (GO:0046475)	2.42233614
88	branched-chain amino acid metabolic process (GO:0009081)	2.42172698
89	axoneme assembly (GO:0035082)	2.41143994
90	inositol phosphate catabolic process (GO:0071545)	2.41040389
91	negative regulation of protein oligomerization (GO:0032460)	2.40004578
92	ER overload response (GO:0006983)	2.39771226
93	purine-containing compound salvage (GO:0043101)	2.39316381
94	cysteine metabolic process (GO:0006534)	2.39147824
95	regulation of execution phase of apoptosis (GO:1900117)	2.39023535
96	regulation of insulin secretion (GO:0050796)	2.38646720
97	eosinophil migration (GO:0072677)	2.38583705
98	macroautophagy (GO:0016236)	2.37980774
99	mitochondrial RNA metabolic process (GO:0000959)	2.37961498
100	somite rostral/caudal axis specification (GO:0032525)	2.37852726

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.09951493
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.04707551
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.76433889
4	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.57600845
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.45223128
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.25218444
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.25193448
8	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.12340612
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.11459399
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.10500766
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.02655778
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.01318781
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.87277628
14	VDR_22108803_ChIP-Seq_LS180_Human	1.86440023
15	P300_19829295_ChIP-Seq_ESCs_Human	1.86398614
16	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.84451430
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.82001906
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.73423207
19	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.72018489
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.71677203
21	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.67244739
22	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.66128603
23	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.64360570
24	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.64360570
25	FUS_26573619_Chip-Seq_HEK293_Human	1.62744641
26	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.62105734
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.61180585
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58696381
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.58568858
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.57673518
31	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.56546863
32	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.56027460
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.55981619
34	EWS_26573619_Chip-Seq_HEK293_Human	1.55558268
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.53066746
36	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.52013114
37	VDR_23849224_ChIP-Seq_CD4+_Human	1.51472615
38	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.48701279
39	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.46690342
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.44545380
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.44545380
42	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.43147388
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.41166775
44	AR_20517297_ChIP-Seq_VCAP_Human	1.40362411
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.40042299
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.38844605
47	CDX2_22108803_ChIP-Seq_LS180_Human	1.38589601
48	HTT_18923047_ChIP-ChIP_STHdh_Human	1.37066959
49	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.36988467
50	NCOR_22424771_ChIP-Seq_293T_Human	1.34519362
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33780924
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.32949604
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32949604
54	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.30821388
55	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26426167
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25127702
57	HOXB7_26014856_ChIP-Seq_BT474_Human	1.24762832
58	AR_25329375_ChIP-Seq_VCAP_Human	1.24520566
59	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.24423029
60	GATA3_26560356_Chip-Seq_TH2_Human	1.23528937
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.23464669
62	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.22448935
63	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.22081998
64	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.21095917
65	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.20405482
66	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.18178652
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15500050
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.14764780
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.14660698
70	SMAD4_21799915_ChIP-Seq_A2780_Human	1.14505518
71	STAT3_23295773_ChIP-Seq_U87_Human	1.14081400
72	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.13719449
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13704598
74	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.11064811
75	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10857387
76	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.10825497
77	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.10506590
78	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10071053
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09308661
80	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.07489788
81	P300_18555785_Chip-Seq_ESCs_Mouse	1.06519739
82	TCF4_23295773_ChIP-Seq_U87_Human	1.06167255
83	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06118087
84	MYC_19829295_ChIP-Seq_ESCs_Human	1.04810889
85	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.04412907
86	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.03076634
87	RBPJ_21746931_ChIP-Seq_IB4_Human	1.02357387
88	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01919708
89	TAF2_19829295_ChIP-Seq_ESCs_Human	1.01901659
90	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01177151
91	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.01002718
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00360688
93	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99722768
94	ERG_20517297_ChIP-Seq_VCAP_Human	0.99439426
95	TCF4_22108803_ChIP-Seq_LS180_Human	0.98495386
96	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.98374601
97	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.98221792
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98158217
99	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97220462
100	PHF8_20622853_ChIP-Seq_HELA_Human	0.96910684

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.91207686
2	MP0002837_dystrophic_cardiac_calcinosis	3.68041672
3	MP0005379_endocrine/exocrine_gland_phen	3.20619820
4	MP0005645_abnormal_hypothalamus_physiol	3.09339294
5	MP0008877_abnormal_DNA_methylation	3.03888147
6	MP0003283_abnormal_digestive_organ	2.96055832
7	MP0002139_abnormal_hepatobiliary_system	2.76032254
8	MP0002693_abnormal_pancreas_physiology	2.65806109
9	MP0002909_abnormal_adrenal_gland	2.52185987
10	MP0005377_hearing/vestibular/ear_phenot	2.39654241
11	MP0003878_abnormal_ear_physiology	2.39654241
12	MP0001944_abnormal_pancreas_morphology	2.34174666
13	MP0002254_reproductive_system_inflammat	2.33167627
14	MP0003787_abnormal_imprinting	2.32517958
15	MP0006072_abnormal_retinal_apoptosis	2.29794963
16	MP0000013_abnormal_adipose_tissue	2.20988130
17	MP0005646_abnormal_pituitary_gland	2.16076340
18	MP0009046_muscle_twitch	2.04962129
19	MP0002163_abnormal_gland_morphology	1.99384559
20	MP0009780_abnormal_chondrocyte_physiolo	1.82345944
21	MP0001485_abnormal_pinna_reflex	1.75338250
22	MP0005332_abnormal_amino_acid	1.70329042
23	MP0002166_altered_tumor_susceptibility	1.67490321
24	MP0004134_abnormal_chest_morphology	1.60861927
25	MP0005551_abnormal_eye_electrophysiolog	1.60259518
26	MP0002078_abnormal_glucose_homeostasis	1.56242633
27	MP0008872_abnormal_physiological_respon	1.55339296
28	MP0002160_abnormal_reproductive_system	1.54956762
29	MP0010329_abnormal_lipoprotein_level	1.50970051
30	MP0001986_abnormal_taste_sensitivity	1.49427019
31	MP0003724_increased_susceptibility_to	1.47793968
32	MP0005671_abnormal_response_to	1.44984241
33	MP0005389_reproductive_system_phenotype	1.44791681
34	MP0008057_abnormal_DNA_replication	1.43322086
35	MP0003183_abnormal_peptide_metabolism	1.43068251
36	MP0005084_abnormal_gallbladder_morpholo	1.42276580
37	MP0005075_abnormal_melanosome_morpholog	1.40224421
38	MP0005220_abnormal_exocrine_pancreas	1.37697855
39	MP0003045_fibrosis	1.37640800
40	MP0005410_abnormal_fertilization	1.37337666
41	MP0003011_delayed_dark_adaptation	1.37149999
42	MP0002138_abnormal_hepatobiliary_system	1.34333092
43	MP0010386_abnormal_urinary_bladder	1.33675515
44	MP0001756_abnormal_urination	1.32590177
45	MP0002006_tumorigenesis	1.30334933
46	MP0009785_altered_susceptibility_to	1.30094688
47	MP0005365_abnormal_bile_salt	1.26156024
48	MP0004885_abnormal_endolymph	1.21880653
49	MP0005636_abnormal_mineral_homeostasis	1.19947220
50	MP0005310_abnormal_salivary_gland	1.19523639
51	MP0005253_abnormal_eye_physiology	1.19484858
52	MP0002102_abnormal_ear_morphology	1.18316886
53	MP0003786_premature_aging	1.15680802
54	MP0010234_abnormal_vibrissa_follicle	1.13535918
55	MP0002876_abnormal_thyroid_physiology	1.11573180
56	MP0001968_abnormal_touch/_nociception	1.11372994
57	MP0000015_abnormal_ear_pigmentation	1.11015130
58	MP0001835_abnormal_antigen_presentation	1.10738281
59	MP0008995_early_reproductive_senescence	1.10366592
60	MP0003953_abnormal_hormone_level	1.10347337
61	MP0005535_abnormal_body_temperature	1.07968966
62	MP0001765_abnormal_ion_homeostasis	1.07624219
63	MP0006036_abnormal_mitochondrial_physio	1.06060005
64	MP0009745_abnormal_behavioral_response	1.05261934
65	MP0004019_abnormal_vitamin_homeostasis	1.01884428
66	MP0005448_abnormal_energy_balance	1.00757497
67	MP0008058_abnormal_DNA_repair	0.99082882
68	MP0000427_abnormal_hair_cycle	0.94993074
69	MP0005647_abnormal_sex_gland	0.94231861
70	MP0005174_abnormal_tail_pigmentation	0.92331358
71	MP0001970_abnormal_pain_threshold	0.91315974
72	MP0001919_abnormal_reproductive_system	0.88932189
73	MP0003633_abnormal_nervous_system	0.88438967
74	MP0004043_abnormal_pH_regulation	0.86659770
75	MP0000372_irregular_coat_pigmentation	0.86109606
76	MP0003172_abnormal_lysosome_physiology	0.85734084
77	MP0006082_CNS_inflammation	0.84373610
78	MP0009643_abnormal_urine_homeostasis	0.81321758
79	MP0001501_abnormal_sleep_pattern	0.79650990
80	MP0002938_white_spotting	0.79356475
81	MP0004142_abnormal_muscle_tone	0.78732370
82	MP0000230_abnormal_systemic_arterial	0.78214791
83	MP0003879_abnormal_hair_cell	0.76589906
84	MP0010307_abnormal_tumor_latency	0.74658100
85	MP0005670_abnormal_white_adipose	0.73604612
86	MP0002272_abnormal_nervous_system	0.73214570
87	MP0005000_abnormal_immune_tolerance	0.73130272
88	MP0002733_abnormal_thermal_nociception	0.72590054
89	MP0002118_abnormal_lipid_homeostasis	0.72518104
90	MP0000631_abnormal_neuroendocrine_gland	0.72058575
91	MP0001905_abnormal_dopamine_level	0.71962573
92	MP0002229_neurodegeneration	0.71812427
93	MP0001764_abnormal_homeostasis	0.71715936
94	MP0002064_seizures	0.70494874
95	MP0005319_abnormal_enzyme/_coenzyme	0.70255568
96	MP0003137_abnormal_impulse_conducting	0.69587780
97	MP0002090_abnormal_vision	0.69519479
98	MP0008469_abnormal_protein_level	0.68717371
99	MP0003638_abnormal_response/metabolism_	0.68677243
100	MP0002928_abnormal_bile_duct	0.67121977

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ketoacidosis (HP:0001993)	4.18512297
2	Hyperinsulinemic hypoglycemia (HP:0000825)	3.85633995
3	Hyperglycemia (HP:0003074)	3.78153701
4	Methylmalonic acidemia (HP:0002912)	3.62432045
5	Ketosis (HP:0001946)	3.58719194
6	Abnormality of vitamin B metabolism (HP:0004340)	3.46086219
7	Hypoglycemic coma (HP:0001325)	3.39159381
8	Large for gestational age (HP:0001520)	3.24640718
9	Attenuation of retinal blood vessels (HP:0007843)	3.11074704
10	Methylmalonic aciduria (HP:0012120)	3.01704293
11	Hypoglycemic seizures (HP:0002173)	3.01661260
12	Hypothermia (HP:0002045)	2.97528565
13	Hepatic necrosis (HP:0002605)	2.93473084
14	Progressive macrocephaly (HP:0004481)	2.84790185
15	Double outlet right ventricle (HP:0001719)	2.82656740
16	Congenital malformation of the right heart (HP:0011723)	2.82656740
17	Congenital sensorineural hearing impairment (HP:0008527)	2.77464216
18	Intestinal atresia (HP:0011100)	2.71883339
19	Mitochondrial inheritance (HP:0001427)	2.71671594
20	Acute necrotizing encephalopathy (HP:0006965)	2.70661355
21	Conjunctival hamartoma (HP:0100780)	2.69637473
22	Constricted visual fields (HP:0001133)	2.68500483
23	Glycosuria (HP:0003076)	2.64221840
24	Abnormality of urine glucose concentration (HP:0011016)	2.64221840
25	Hepatocellular necrosis (HP:0001404)	2.60834161
26	Homocystinuria (HP:0002156)	2.58864229
27	Abnormality of homocysteine metabolism (HP:0010919)	2.58864229
28	Increased hepatocellular lipid droplets (HP:0006565)	2.57395514
29	Severe visual impairment (HP:0001141)	2.54431932
30	Acute encephalopathy (HP:0006846)	2.50704824
31	Abolished electroretinogram (ERG) (HP:0000550)	2.49958827
32	Neoplasm of the adrenal gland (HP:0100631)	2.49680984
33	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.47004407
34	Increased CSF lactate (HP:0002490)	2.46700897
35	Lipid accumulation in hepatocytes (HP:0006561)	2.46298038
36	Congenital stationary night blindness (HP:0007642)	2.42402365
37	Agitation (HP:0000713)	2.39710807
38	Abnormality of alanine metabolism (HP:0010916)	2.39179459
39	Hyperalaninemia (HP:0003348)	2.39179459
40	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.39179459
41	Thyroiditis (HP:0100646)	2.39146685
42	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.38360688
43	Insulin-resistant diabetes mellitus (HP:0000831)	2.36926097
44	Pancreatic cysts (HP:0001737)	2.36671616
45	Pendular nystagmus (HP:0012043)	2.34093791
46	Symptomatic seizures (HP:0011145)	2.32806397
47	Poor suck (HP:0002033)	2.32774894
48	Abnormality of vitamin metabolism (HP:0100508)	2.28887714
49	Late onset (HP:0003584)	2.24032246
50	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.22484556
51	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.22484556
52	Generalized aminoaciduria (HP:0002909)	2.22309147
53	Abnormal mitochondria in muscle tissue (HP:0008316)	2.22166050
54	Prominent metopic ridge (HP:0005487)	2.20178859
55	Abnormality of endocrine pancreas physiology (HP:0012093)	2.19272274
56	Abnormality of the pancreatic islet cells (HP:0006476)	2.19272274
57	Type 2 muscle fiber atrophy (HP:0003554)	2.19103925
58	Pancreatic islet-cell hyperplasia (HP:0004510)	2.19094323
59	Abnormality of the renal cortex (HP:0011035)	2.17021999
60	Hypomagnesemia (HP:0002917)	2.11908137
61	Neoplasm of the adrenal cortex (HP:0100641)	2.11905290
62	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.07996678
63	Dicarboxylic aciduria (HP:0003215)	2.07996678
64	Pancreatic fibrosis (HP:0100732)	2.07316958
65	Hemiparesis (HP:0001269)	2.05284202
66	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.03444149
67	Abnormal rod and cone electroretinograms (HP:0008323)	2.01466616
68	Hematochezia (HP:0002573)	2.00826201
69	Hamartoma of the eye (HP:0010568)	2.00410345
70	True hermaphroditism (HP:0010459)	1.98323451
71	Furrowed tongue (HP:0000221)	1.98043274
72	Vacuolated lymphocytes (HP:0001922)	1.96480532
73	Renal Fanconi syndrome (HP:0001994)	1.95816869
74	Cerebral edema (HP:0002181)	1.94445900
75	Increased serum lactate (HP:0002151)	1.94265422
76	Tongue fasciculations (HP:0001308)	1.92476786
77	Molar tooth sign on MRI (HP:0002419)	1.90726082
78	Abnormality of midbrain morphology (HP:0002418)	1.90726082
79	Exertional dyspnea (HP:0002875)	1.89657917
80	Megaloblastic anemia (HP:0001889)	1.89373210
81	Renal cortical cysts (HP:0000803)	1.89095693
82	3-Methylglutaconic aciduria (HP:0003535)	1.87690802
83	Lactic acidosis (HP:0003128)	1.84718092
84	Stomatitis (HP:0010280)	1.84456479
85	Muscular hypotonia of the trunk (HP:0008936)	1.80126317
86	Enlarged penis (HP:0000040)	1.79609786
87	Muscle fiber atrophy (HP:0100295)	1.78501297
88	Meningioma (HP:0002858)	1.77718474
89	Elevated erythrocyte sedimentation rate (HP:0003565)	1.77661677
90	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.77309766
91	Hypoalbuminemia (HP:0003073)	1.76508860
92	Abnormal albumin level (HP:0012116)	1.76508860
93	Abnormality of the metopic suture (HP:0005556)	1.72635517
94	Respiratory failure (HP:0002878)	1.71788892
95	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.71482637
96	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.71482637
97	Prostate neoplasm (HP:0100787)	1.71479073
98	Polydipsia (HP:0001959)	1.71366216
99	Abnormal drinking behavior (HP:0030082)	1.71366216
100	Optic disc pallor (HP:0000543)	1.71360051

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.40949129
2	MST4	3.73424994
3	ADRBK2	3.12768065
4	TAF1	3.05494203
5	FGFR2	2.53209441
6	STK16	2.52481765
7	ZAK	2.12241698
8	TAOK3	2.08529509
9	AKT3	2.08336307
10	STK24	2.01178614
11	VRK2	1.99990131
12	INSRR	1.92986658
13	GRK1	1.89847856
14	STK38L	1.67623494
15	ACVR1B	1.67340780
16	BCKDK	1.50002743
17	VRK1	1.49580980
18	CASK	1.47293132
19	FGFR3	1.46419672
20	WNK3	1.46099441
21	MAP4K2	1.44141860
22	TXK	1.43593372
23	ITK	1.41284295
24	DAPK2	1.40306951
25	NUAK1	1.38274858
26	SIK3	1.36432729
27	CSNK1G3	1.31081221
28	CSNK1G1	1.29268367
29	MAP3K4	1.23305235
30	NTRK3	1.16927213
31	NLK	1.13962095
32	CSNK1G2	1.10304326
33	PRKCE	1.08679841
34	TNK2	1.08164927
35	STK3	1.05049337
36	PRKCG	1.04946705
37	MAP2K6	1.04784547
38	TEC	1.03908157
39	EIF2AK3	1.01205584
40	SGK2	0.94306179
41	MAPKAPK3	0.93110470
42	WNK4	0.91392665
43	CSNK1A1L	0.90934939
44	TNIK	0.90631206
45	TLK1	0.86694612
46	DAPK1	0.85595072
47	IKBKB	0.85316722
48	SGK223	0.82975503
49	SGK494	0.82975503
50	EPHA3	0.82655537
51	PLK4	0.82260801
52	OXSR1	0.82116251
53	TSSK6	0.81648119
54	BMPR2	0.77424711
55	MAP3K12	0.74691726
56	PLK3	0.74365619
57	BMPR1B	0.72326559
58	TRIM28	0.71689316
59	PLK2	0.70287362
60	MAP3K2	0.70181559
61	PIK3CG	0.70080807
62	PTK2B	0.69651061
63	PHKG2	0.67584777
64	PHKG1	0.67584777
65	STK39	0.63848191
66	MAPKAPK5	0.62254539
67	ADRBK1	0.61940497
68	IKBKE	0.57958959
69	TRPM7	0.56785842
70	STK4	0.53765234
71	EIF2AK1	0.53139300
72	MAP2K1	0.53110532
73	CSNK1A1	0.51949659
74	HIPK2	0.51629380
75	FER	0.50443785
76	DYRK2	0.50155923
77	CAMK2D	0.50072708
78	PAK3	0.49715377
79	KDR	0.48556589
80	PASK	0.47734032
81	RPS6KA5	0.46722750
82	PINK1	0.46402043
83	PRKCI	0.45903063
84	PRKCH	0.45377605
85	JAK1	0.42717483
86	EIF2AK2	0.41816503
87	BLK	0.40319404
88	MARK3	0.38760609
89	BTK	0.38561078
90	LYN	0.36990425
91	NME1	0.36291728
92	GRK7	0.34549034
93	CAMK2A	0.33258162
94	CSNK1D	0.30534235
95	GRK5	0.29330618
96	SYK	0.29309626
97	PRKCA	0.28537788
98	BUB1	0.27352235
99	IRAK1	0.24995114
100	PRKCQ	0.23927587

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	5.66255362
2	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.43930620
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.89579960
4	Protein export_Homo sapiens_hsa03060	2.79692562
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.65218887
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.63162665
7	Butanoate metabolism_Homo sapiens_hsa00650	2.42134281
8	Sulfur metabolism_Homo sapiens_hsa00920	2.38712469
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.38151466
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.03225352
11	Tryptophan metabolism_Homo sapiens_hsa00380	2.02217313
12	Propanoate metabolism_Homo sapiens_hsa00640	1.85486844
13	Parkinsons disease_Homo sapiens_hsa05012	1.84971447
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.71943462
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.68936384
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65457457
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.65163072
18	Peroxisome_Homo sapiens_hsa04146	1.63134026
19	Proteasome_Homo sapiens_hsa03050	1.56638860
20	Folate biosynthesis_Homo sapiens_hsa00790	1.56197878
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.52706158
22	Insulin secretion_Homo sapiens_hsa04911	1.46943944
23	Alzheimers disease_Homo sapiens_hsa05010	1.39379581
24	Collecting duct acid secretion_Homo sapiens_hsa04966	1.38551751
25	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.36410102
26	Phototransduction_Homo sapiens_hsa04744	1.33724500
27	One carbon pool by folate_Homo sapiens_hsa00670	1.31356650
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.20906570
29	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.19703119
30	Homologous recombination_Homo sapiens_hsa03440	1.18103214
31	Graft-versus-host disease_Homo sapiens_hsa05332	1.16123058
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.13656282
33	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.12918643
34	Fatty acid elongation_Homo sapiens_hsa00062	1.12735659
35	Other glycan degradation_Homo sapiens_hsa00511	1.12418043
36	RNA polymerase_Homo sapiens_hsa03020	1.10540037
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.09557146
38	Glutathione metabolism_Homo sapiens_hsa00480	1.04949352
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.03680770
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.03376040
41	beta-Alanine metabolism_Homo sapiens_hsa00410	1.02946741
42	Huntingtons disease_Homo sapiens_hsa05016	1.02359513
43	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.95001943
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.93503031
45	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.92954754
46	Basal transcription factors_Homo sapiens_hsa03022	0.90934487
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.90004289
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.89018928
49	Serotonergic synapse_Homo sapiens_hsa04726	0.88476102
50	Allograft rejection_Homo sapiens_hsa05330	0.86805633
51	Asthma_Homo sapiens_hsa05310	0.84117633
52	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.81487008
53	Cardiac muscle contraction_Homo sapiens_hsa04260	0.80921333
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79785553
55	Regulation of autophagy_Homo sapiens_hsa04140	0.77405560
56	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.76485566
57	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.75548678
58	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.75454398
59	Arginine biosynthesis_Homo sapiens_hsa00220	0.73079720
60	Metabolic pathways_Homo sapiens_hsa01100	0.70897297
61	Rheumatoid arthritis_Homo sapiens_hsa05323	0.70830126
62	Primary immunodeficiency_Homo sapiens_hsa05340	0.68227212
63	Circadian entrainment_Homo sapiens_hsa04713	0.68078463
64	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67832688
65	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.67136741
66	Antigen processing and presentation_Homo sapiens_hsa04612	0.66401388
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66101043
68	Retinol metabolism_Homo sapiens_hsa00830	0.64977344
69	Fatty acid degradation_Homo sapiens_hsa00071	0.64879052
70	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.62777909
71	Non-homologous end-joining_Homo sapiens_hsa03450	0.60212349
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58444848
73	ABC transporters_Homo sapiens_hsa02010	0.58413059
74	Type II diabetes mellitus_Homo sapiens_hsa04930	0.58259610
75	RNA degradation_Homo sapiens_hsa03018	0.58199063
76	Nitrogen metabolism_Homo sapiens_hsa00910	0.57960030
77	Purine metabolism_Homo sapiens_hsa00230	0.56018742
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.55965511
79	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55948912
80	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.55290876
81	Steroid biosynthesis_Homo sapiens_hsa00100	0.54237948
82	Histidine metabolism_Homo sapiens_hsa00340	0.50842006
83	Sphingolipid metabolism_Homo sapiens_hsa00600	0.50669241
84	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.49121974
85	Taste transduction_Homo sapiens_hsa04742	0.48804570
86	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.47375400
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.47130435
88	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.45968228
89	GABAergic synapse_Homo sapiens_hsa04727	0.43171009
90	Nicotine addiction_Homo sapiens_hsa05033	0.42152567
91	Circadian rhythm_Homo sapiens_hsa04710	0.41309572
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.40197176
93	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39871785
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.39639331
95	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.38018973
96	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37319444
97	Olfactory transduction_Homo sapiens_hsa04740	0.36749517
98	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.36079200
99	Mismatch repair_Homo sapiens_hsa03430	0.34779110
100	Caffeine metabolism_Homo sapiens_hsa00232	0.33846954

USP41

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »