USP43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.52347763
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.48558774
3motile cilium assembly (GO:0044458)9.45780134
4epithelial cilium movement (GO:0003351)8.09808500
5intestinal epithelial cell development (GO:0060576)7.23242240
6interferon-gamma secretion (GO:0072643)6.68545066
7vitamin transmembrane transport (GO:0035461)5.72160100
8axoneme assembly (GO:0035082)5.67039892
9bundle of His cell to Purkinje myocyte communication (GO:0086069)5.55547510
10regulation of cilium movement (GO:0003352)5.09889794
11left/right pattern formation (GO:0060972)4.96126874
12regulation of hippo signaling (GO:0035330)4.69126821
13regulation of cardioblast differentiation (GO:0051890)4.68985299
14primary alcohol catabolic process (GO:0034310)4.68400627
15desmosome organization (GO:0002934)4.56128683
16trophectodermal cell differentiation (GO:0001829)4.36109771
17diterpenoid biosynthetic process (GO:0016102)4.22253616
18lung epithelium development (GO:0060428)4.09312154
19pyrimidine-containing compound transmembrane transport (GO:0072531)4.09215902
20intestinal absorption (GO:0050892)4.00806349
21labyrinthine layer development (GO:0060711)3.96828393
22negative regulation of keratinocyte proliferation (GO:0010839)3.96082127
23ethanol metabolic process (GO:0006067)3.91698215
24ventricular system development (GO:0021591)3.85505215
25mitotic metaphase plate congression (GO:0007080)3.84386837
26microtubule bundle formation (GO:0001578)3.82182409
27tight junction assembly (GO:0070830)3.81108895
28left/right axis specification (GO:0070986)3.73881604
29regulation of water loss via skin (GO:0033561)3.71105671
30hemidesmosome assembly (GO:0031581)3.70793007
31notochord development (GO:0030903)3.68671350
32establishment of apical/basal cell polarity (GO:0035089)3.64596852
33apical protein localization (GO:0045176)3.59862309
34paraxial mesoderm development (GO:0048339)3.57509490
35glomerular epithelial cell development (GO:0072310)3.52318864
36asymmetric protein localization (GO:0008105)3.46744481
37centriole assembly (GO:0098534)3.46434566
38anterior/posterior axis specification, embryo (GO:0008595)3.45246100
39regulation of interleukin-5 production (GO:0032674)3.44928489
40lung-associated mesenchyme development (GO:0060484)3.42459475
41intestinal cholesterol absorption (GO:0030299)3.42107207
42ventricular cardiac muscle cell action potential (GO:0086005)3.38172891
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.37271449
44cilium organization (GO:0044782)3.35671284
45negative regulation of T cell differentiation in thymus (GO:0033085)3.33632319
46epithelial cell-cell adhesion (GO:0090136)3.33300988
47establishment of monopolar cell polarity (GO:0061162)3.33010131
48establishment or maintenance of monopolar cell polarity (GO:0061339)3.33010131
49cilium assembly (GO:0042384)3.30160750
50phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.29691620
51sphingoid metabolic process (GO:0046519)3.28583060
52O-glycan processing (GO:0016266)3.28111549
53intraciliary transport (GO:0042073)3.25166114
54metaphase plate congression (GO:0051310)3.23492564
55columnar/cuboidal epithelial cell development (GO:0002066)3.19856222
56ribosome assembly (GO:0042255)3.14508988
57establishment of tissue polarity (GO:0007164)3.13740394
58establishment of planar polarity (GO:0001736)3.13740394
59establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.08732847
60mitotic chromosome condensation (GO:0007076)3.06195676
61establishment of skin barrier (GO:0061436)3.04897745
62regulation of microtubule-based movement (GO:0060632)3.04756714
63hippo signaling (GO:0035329)3.04726607
64response to xenobiotic stimulus (GO:0009410)3.03441242
65positive regulation of epidermal cell differentiation (GO:0045606)3.02151437
66regulation of posttranscriptional gene silencing (GO:0060147)3.01770903
67regulation of gene silencing by miRNA (GO:0060964)3.01770903
68regulation of gene silencing by RNA (GO:0060966)3.01770903
69regulation of sister chromatid cohesion (GO:0007063)3.00087785
70polarized epithelial cell differentiation (GO:0030859)2.98414824
71cell differentiation involved in embryonic placenta development (GO:0060706)2.97647247
72UDP-N-acetylglucosamine metabolic process (GO:0006047)2.97555407
73protein localization to kinetochore (GO:0034501)2.93028786
74iron ion import (GO:0097286)2.92690564
75folic acid metabolic process (GO:0046655)2.91836094
76establishment or maintenance of bipolar cell polarity (GO:0061245)2.91590450
77establishment or maintenance of apical/basal cell polarity (GO:0035088)2.91590450
78formation of translation preinitiation complex (GO:0001731)2.91263974
79sphingomyelin metabolic process (GO:0006684)2.90626447
80calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.90198435
81ectoderm development (GO:0007398)2.86072053
82piRNA metabolic process (GO:0034587)2.85227811
83retinoic acid metabolic process (GO:0042573)2.83107806
84kinetochore assembly (GO:0051382)2.83008523
85sulfate transmembrane transport (GO:1902358)2.81860639
86inner cell mass cell proliferation (GO:0001833)2.81720468
87regulation of transforming growth factor beta2 production (GO:0032909)2.80562210
88DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.79849076
89regulation of keratinocyte proliferation (GO:0010837)2.78614178
90carnitine transmembrane transport (GO:1902603)2.77601450
91negative regulation of meiosis (GO:0045835)2.77228448
92cell projection assembly (GO:0030031)2.77048690
93ethanol oxidation (GO:0006069)2.77016679
94terpenoid biosynthetic process (GO:0016114)2.75687927
95intracellular estrogen receptor signaling pathway (GO:0030520)2.73479628
96multicellular organismal water homeostasis (GO:0050891)2.72749273
97microtubule-based movement (GO:0007018)2.71341322
98positive regulation of Cdc42 GTPase activity (GO:0043089)2.70875276
99androgen biosynthetic process (GO:0006702)2.70690190
100protein autoprocessing (GO:0016540)2.70264850
101cysteine metabolic process (GO:0006534)2.69226219
102positive regulation of SMAD protein import into nucleus (GO:0060391)2.68708270
103amino-acid betaine transport (GO:0015838)2.68118669
104carnitine transport (GO:0015879)2.68118669
105positive regulation of pseudopodium assembly (GO:0031274)2.67875669
106carnitine metabolic process (GO:0009437)2.67058731
107modified amino acid transport (GO:0072337)2.66366102
108positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.65319396
109regulation of keratinocyte differentiation (GO:0045616)2.64171888
110quaternary ammonium group transport (GO:0015697)2.63114811
111regulation of Cdc42 GTPase activity (GO:0043088)2.62674372
112DNA damage response, signal transduction resulting in transcription (GO:0042772)2.62525355
113cell-cell junction assembly (GO:0007043)2.59900264
114biotin metabolic process (GO:0006768)2.58834696
115branching involved in mammary gland duct morphogenesis (GO:0060444)2.58759692
116mitotic nuclear envelope disassembly (GO:0007077)2.58614833
117diol metabolic process (GO:0034311)2.58564240
118exogenous drug catabolic process (GO:0042738)2.58402218
119gap junction assembly (GO:0016264)2.57242302
120filopodium assembly (GO:0046847)2.56610960
121sulfate transport (GO:0008272)2.55470134
122cytoskeletal anchoring at plasma membrane (GO:0007016)2.54514945
123regulation of interleukin-13 production (GO:0032656)2.54284881
124DNA damage induced protein phosphorylation (GO:0006975)2.54059316
125nuclear envelope disassembly (GO:0051081)2.53956859
126membrane disassembly (GO:0030397)2.53956859
127embryonic foregut morphogenesis (GO:0048617)2.52897091
128flavonoid metabolic process (GO:0009812)2.51511014
129regulation of translation in response to stress (GO:0043555)2.50495670
130positive regulation of smoothened signaling pathway (GO:0045880)2.49695541
131dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.49363212
132regulation of epidermal cell differentiation (GO:0045604)2.48175836
133activation of Rac GTPase activity (GO:0032863)2.47967653
134mitotic sister chromatid segregation (GO:0000070)2.47940282
135proline metabolic process (GO:0006560)2.47884584
136purine nucleobase biosynthetic process (GO:0009113)2.47417163
137lateral sprouting from an epithelium (GO:0060601)2.47379844
138establishment of chromosome localization (GO:0051303)2.46820077
139nodal signaling pathway (GO:0038092)2.46666787
140androgen metabolic process (GO:0008209)2.45876358
141heterochromatin organization (GO:0070828)2.45024034
142labyrinthine layer blood vessel development (GO:0060716)2.44606993
143protein localization to chromosome, centromeric region (GO:0071459)2.44575902
144positive regulation of protein localization to plasma membrane (GO:1903078)2.44358278
145membrane budding (GO:0006900)2.43109190
146nucleobase biosynthetic process (GO:0046112)2.43100518
147positive regulation of epidermis development (GO:0045684)2.42903645
148sphingosine metabolic process (GO:0006670)2.42623399
149regulation of spindle organization (GO:0090224)2.41711663
150excretion (GO:0007588)2.40981746
151cellular component assembly involved in morphogenesis (GO:0010927)2.40578033
152keratinocyte development (GO:0003334)2.39385865
153primary alcohol metabolic process (GO:0034308)2.39289096
154regulation of epidermis development (GO:0045682)2.38901681
155maturation of 5.8S rRNA (GO:0000460)2.38231348
156regulation of tight junction assembly (GO:2000810)2.37199407
157regulation of histone H3-K27 methylation (GO:0061085)2.36537394
158water homeostasis (GO:0030104)2.36502839
159proline biosynthetic process (GO:0006561)2.35180896
160regulation of SMAD protein import into nucleus (GO:0060390)2.33826619
161cell junction maintenance (GO:0034331)2.33740947
162regulation of pseudopodium assembly (GO:0031272)2.33706489
163folic acid transport (GO:0015884)2.33180458
164epithelial cell maturation (GO:0002070)2.32489374
165sperm capacitation (GO:0048240)2.32449906
166amino-acid betaine metabolic process (GO:0006577)2.32408832
167nucleoside diphosphate phosphorylation (GO:0006165)2.32125901
168negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.31877756
169ear development (GO:0043583)2.26689211
170regulation of retinoic acid receptor signaling pathway (GO:0048385)2.26313874
171retinol metabolic process (GO:0042572)2.25961647
172negative regulation of humoral immune response (GO:0002921)2.25261025
173axonemal dynein complex assembly (GO:0070286)13.8017637
174cilium or flagellum-dependent cell motility (GO:0001539)11.3318031

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.16530327
2E2F7_22180533_ChIP-Seq_HELA_Human3.52661589
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.47321524
4NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.08612328
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.82207012
6AR_21909140_ChIP-Seq_LNCAP_Human2.71455220
7POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.70822805
8ZNF263_19887448_ChIP-Seq_K562_Human2.66226726
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.58899764
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.58899764
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.58899764
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.36855357
13CDX2_20551321_ChIP-Seq_CACO-2_Human2.36711923
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.33658340
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28965792
16TCF3_18692474_ChIP-Seq_MEFs_Mouse2.25632425
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.24442940
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.22512475
19NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.21644893
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.20155840
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.20065407
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.12780118
23AHR_22903824_ChIP-Seq_MCF-7_Human2.10935551
24ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.09257137
25KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.04598145
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03816687
27* GATA6_25053715_ChIP-Seq_YYC3_Human1.96056618
28FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.95102955
29SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.93216482
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.91038350
31* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.90062665
32ATF3_27146783_Chip-Seq_COLON_Human1.89143875
33TCF3_18692474_ChIP-Seq_MESCs_Mouse1.86524224
34GATA4_25053715_ChIP-Seq_YYC3_Human1.86028000
35* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.85841762
36P63_26484246_Chip-Seq_KERATINOCYTES_Human1.83779561
37SOX9_24532713_ChIP-Seq_HFSC_Mouse1.82179497
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80401935
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.76457404
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.76217344
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67197241
42* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66697145
43* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.66007344
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65985721
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.65195134
46RACK7_27058665_Chip-Seq_MCF-7_Human1.64550170
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.61561104
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57343259
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.54472747
50* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.54471473
51* SMC4_20622854_ChIP-Seq_HELA_Human1.54386727
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.52030559
53FOXA1_25552417_ChIP-Seq_VCAP_Human1.49765487
54* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49502872
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47759604
56* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.46795102
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46169995
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45948874
59PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.45772799
60DROSHA_22980978_ChIP-Seq_HELA_Human1.45406262
61NANOG_18692474_ChIP-Seq_MESCs_Mouse1.45032869
62TP63_22573176_ChIP-Seq_HFKS_Human1.42407485
63CTNNB1_20460455_ChIP-Seq_HCT116_Human1.42017943
64TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.39175478
65POU5F1_16518401_ChIP-PET_MESCs_Mouse1.38915429
66* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38734988
67EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.36861647
68NANOG_18692474_ChIP-Seq_MEFs_Mouse1.36447821
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.36045087
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35968084
71ESR1_20079471_ChIP-ChIP_T-47D_Human1.35348232
72* KLF5_25053715_ChIP-Seq_YYC3_Human1.35336750
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33088338
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.32627154
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31988102
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31988102
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.31614752
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29899532
79FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29692268
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28599017
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.27303709
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27066986
83SOX2_20726797_ChIP-Seq_SW620_Human1.26812886
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24923146
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.24852474
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21434613
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21270510
88KAP1_27257070_Chip-Seq_ESCs_Mouse1.20894501
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.20312820
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19493650
91GATA1_26923725_Chip-Seq_HPCs_Mouse1.19157819
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17246563
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16455347
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16187840
95FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.15869519
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15230287
97SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14712930
98GATA3_24758297_ChIP-Seq_MCF-7_Human1.14065429
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13678653
100LXR_22158963_ChIP-Seq_LIVER_Mouse1.13363478
101OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13036994
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12176219
103P68_20966046_ChIP-Seq_HELA_Human1.12149000
104AR_21572438_ChIP-Seq_LNCaP_Human1.11084687
105PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10398210
106LXR_22292898_ChIP-Seq_THP-1_Human1.09805763
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09707931
108ERG_21242973_ChIP-ChIP_JURKAT_Human1.09682351
109POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.08395119
110RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08035912
111* TP63_23658742_ChIP-Seq_EP156T_Human1.06797603
112* FOXA2_19822575_ChIP-Seq_HepG2_Human1.06361948
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05119099
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03175788
115* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.02957181
116E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02567355
117SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02225612
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01565284
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01315295
120NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00778016
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99421348
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98911770
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98409508
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98090118
125CLOCK_20551151_ChIP-Seq_293T_Human0.97628998
126FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96942353
127DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95853285
128NANOG_16518401_ChIP-PET_MESCs_Mouse0.95774672
129ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94112464
130* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93210660
131STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93069114
132* CREB1_26743006_Chip-Seq_LNCaP_Human0.92424575
133STAT1_20625510_ChIP-Seq_HELA_Human0.91534971
134UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91517988
135EGR1_19374776_ChIP-ChIP_THP-1_Human0.91425867
136* TET1_21490601_ChIP-Seq_MESCs_Mouse0.90801312
137TP53_22127205_ChIP-Seq_IMR90_Human0.90609335
138CHD1_26751641_Chip-Seq_LNCaP_Human0.90588754
139HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90223926
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.89934867
141CTCF_20526341_ChIP-Seq_ESCs_Human0.88830236
142* ELF5_23300383_ChIP-Seq_T47D_Human0.87350030
143POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.86649994
144STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86446638
145TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86444305
146CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86361277
147CTCF_27219007_Chip-Seq_Bcells_Human0.85908079

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.18626231
2MP0003693_abnormal_embryo_hatching4.09886896
3MP0004264_abnormal_extraembryonic_tissu3.79549956
4MP0008875_abnormal_xenobiotic_pharmacok3.63593522
5MP0010352_gastrointestinal_tract_polyps3.61335925
6MP0003136_yellow_coat_color3.28492436
7MP0000537_abnormal_urethra_morphology2.94827581
8MP0009780_abnormal_chondrocyte_physiolo2.75677653
9MP0003705_abnormal_hypodermis_morpholog2.71553852
10MP0004957_abnormal_blastocyst_morpholog2.58433324
11MP0003941_abnormal_skin_development2.48319486
12MP0002796_impaired_skin_barrier2.44780212
13MP0004043_abnormal_pH_regulation2.41321799
14MP0003111_abnormal_nucleus_morphology2.32790923
15MP0003718_maternal_effect2.28276998
16MP0010678_abnormal_skin_adnexa2.23402103
17MP0002876_abnormal_thyroid_physiology2.18179665
18MP0001666_abnormal_nutrient_absorption2.09236056
19MP0003119_abnormal_digestive_system2.07054881
20MP0000462_abnormal_digestive_system1.98300348
21MP0002132_abnormal_respiratory_system1.96309745
22MP0000579_abnormal_nail_morphology1.87386625
23MP0005623_abnormal_meninges_morphology1.85732646
24MP0002098_abnormal_vibrissa_morphology1.83077444
25MP0000490_abnormal_crypts_of1.82797236
26MP0003315_abnormal_perineum_morphology1.81652821
27MP0000383_abnormal_hair_follicle1.75412120
28MP0002254_reproductive_system_inflammat1.72943781
29MP0002653_abnormal_ependyma_morphology1.72067147
30MP0000678_abnormal_parathyroid_gland1.70842579
31MP0005501_abnormal_skin_physiology1.69773584
32MP0001730_embryonic_growth_arrest1.69042361
33MP0003077_abnormal_cell_cycle1.65958812
34MP0003183_abnormal_peptide_metabolism1.61404256
35MP0003566_abnormal_cell_adhesion1.60226658
36MP0004133_heterotaxia1.54924313
37MP0002139_abnormal_hepatobiliary_system1.51748586
38MP0001765_abnormal_ion_homeostasis1.51711208
39MP0002160_abnormal_reproductive_system1.50514492
40MP0003890_abnormal_embryonic-extraembry1.49743243
41MP0005451_abnormal_body_composition1.48152525
42MP0005380_embryogenesis_phenotype1.48105465
43MP0001672_abnormal_embryogenesis/_devel1.48105465
44MP0001849_ear_inflammation1.47178173
45MP0003453_abnormal_keratinocyte_physiol1.46729130
46MP0002085_abnormal_embryonic_tissue1.45806426
47MP0009053_abnormal_anal_canal1.41624054
48MP0000762_abnormal_tongue_morphology1.40920542
49MP0005367_renal/urinary_system_phenotyp1.39551914
50MP0000516_abnormal_urinary_system1.39551914
51MP0002086_abnormal_extraembryonic_tissu1.39234458
52MP0002084_abnormal_developmental_patter1.39213296
53MP0010094_abnormal_chromosome_stability1.37548879
54MP0005085_abnormal_gallbladder_physiolo1.37513636
55MP0004185_abnormal_adipocyte_glucose1.37237643
56MP0005076_abnormal_cell_differentiation1.35266413
57MP0004858_abnormal_nervous_system1.35129576
58MP0008004_abnormal_stomach_pH1.33663987
59MP0005365_abnormal_bile_salt1.30052849
60MP0003984_embryonic_growth_retardation1.29328590
61MP0001216_abnormal_epidermal_layer1.29035009
62MP0005187_abnormal_penis_morphology1.28392832
63MP0002088_abnormal_embryonic_growth/wei1.27891389
64MP0001727_abnormal_embryo_implantation1.27394310
65MP0000477_abnormal_intestine_morphology1.27363543
66MP0005083_abnormal_biliary_tract1.27115514
67MP0000627_abnormal_mammary_gland1.27112275
68MP0003567_abnormal_fetal_cardiomyocyte1.24488481
69MP0005248_abnormal_Harderian_gland1.24273051
70MP0000350_abnormal_cell_proliferation1.22469549
71MP0000377_abnormal_hair_follicle1.20207144
72MP0004019_abnormal_vitamin_homeostasis1.19933660
73MP0005670_abnormal_white_adipose1.17915662
74MP0001984_abnormal_olfaction1.17298835
75MP0001346_abnormal_lacrimal_gland1.17154771
76MP0010030_abnormal_orbit_morphology1.16795874
77MP0005377_hearing/vestibular/ear_phenot1.16308802
78MP0003878_abnormal_ear_physiology1.16308802
79MP0001697_abnormal_embryo_size1.15965284
80MP0003937_abnormal_limbs/digits/tail_de1.11649219
81MP0008932_abnormal_embryonic_tissue1.07764845
82MP0002009_preneoplasia1.06127038
83MP0002249_abnormal_larynx_morphology1.05882864
84MP0003866_abnormal_defecation1.04085010
85MP0005409_darkened_coat_color1.02532509
86MP0003936_abnormal_reproductive_system1.00910986
87MP0005257_abnormal_intraocular_pressure1.00719977
88MP0003123_paternal_imprinting0.98759566
89MP0000566_synostosis0.98588729
90MP0004484_altered_response_of0.97763248
91MP0000467_abnormal_esophagus_morphology0.97282303
92MP0005395_other_phenotype0.96773083
93MP0005636_abnormal_mineral_homeostasis0.96414739
94MP0002163_abnormal_gland_morphology0.94495018
95MP0005646_abnormal_pituitary_gland0.93638497
96MP0002080_prenatal_lethality0.92382231
97MP0000647_abnormal_sebaceous_gland0.91623740
98MP0004381_abnormal_hair_follicle0.89111756
99MP0000427_abnormal_hair_cycle0.88004407
100MP0000681_abnormal_thyroid_gland0.87468619
101MP0000613_abnormal_salivary_gland0.86141670
102MP0005647_abnormal_sex_gland0.86044483
103MP0004233_abnormal_muscle_weight0.84909485
104MP0000470_abnormal_stomach_morphology0.84613866
105MP0005389_reproductive_system_phenotype0.83435444
106MP0001664_abnormal_digestion0.83298332
107MP0002168_other_aberrant_phenotype0.81821867
108MP0003879_abnormal_hair_cell0.81739405
109MP0004782_abnormal_surfactant_physiolog0.79768623
110MP0010771_integument_phenotype0.79393595
111MP0002060_abnormal_skin_morphology0.78326931
112MP0004197_abnormal_fetal_growth/weight/0.78197744
113MP0002909_abnormal_adrenal_gland0.78144141
114MP0009643_abnormal_urine_homeostasis0.77025657
115MP0003115_abnormal_respiratory_system0.76922255
116MP0003806_abnormal_nucleotide_metabolis0.75075002
117MP0010307_abnormal_tumor_latency0.74905016
118MP0002111_abnormal_tail_morphology0.73708307
119MP0003935_abnormal_craniofacial_develop0.72866615
120MP0000432_abnormal_head_morphology0.72473443
121MP0001881_abnormal_mammary_gland0.72177292
122MP0000653_abnormal_sex_gland0.70496274
123MP0001944_abnormal_pancreas_morphology0.70393833
124MP0005360_urolithiasis0.69800745
125MP0002210_abnormal_sex_determination0.69411823
126MP0003221_abnormal_cardiomyocyte_apopto0.69371682
127MP0008057_abnormal_DNA_replication0.69328726
128MP0009379_abnormal_foot_pigmentation0.69204156
129MP0004272_abnormal_basement_membrane0.68939048
130MP0001145_abnormal_male_reproductive0.68739797
131MP0003699_abnormal_female_reproductive0.68591411
132MP0002282_abnormal_trachea_morphology0.68255254
133MP0003755_abnormal_palate_morphology0.68027153
134MP0002234_abnormal_pharynx_morphology0.67811625
135MP0001873_stomach_inflammation0.67499214
136MP0002277_abnormal_respiratory_mucosa0.67316742
137MP0003950_abnormal_plasma_membrane0.67234106
138MP0003938_abnormal_ear_development0.65665798
139MP0003861_abnormal_nervous_system0.65306688
140MP0002089_abnormal_postnatal_growth/wei0.64823781
141MP0000003_abnormal_adipose_tissue0.64038052
142MP0005220_abnormal_exocrine_pancreas0.63048991
143MP0003191_abnormal_cellular_cholesterol0.62480594
144MP0003942_abnormal_urinary_system0.61818216
145MP0002697_abnormal_eye_size0.61426679
146MP0005666_abnormal_adipose_tissue0.60570708

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.32439466
2Abnormal respiratory motile cilium morphology (HP:0005938)9.32439466
3Dynein arm defect of respiratory motile cilia (HP:0012255)9.13204536
4Absent/shortened dynein arms (HP:0200106)9.13204536
5Abnormal respiratory motile cilium physiology (HP:0012261)8.93788517
6Abnormal ciliary motility (HP:0012262)8.66189497
7Rhinitis (HP:0012384)8.10439424
8Chronic bronchitis (HP:0004469)7.45662955
9Bronchiectasis (HP:0002110)6.17008076
10Right ventricular cardiomyopathy (HP:0011663)5.36021474
11Nasal polyposis (HP:0100582)4.93264714
12Infertility (HP:0000789)4.04666789
13Abnormality of the nasal mucosa (HP:0000433)3.88090767
14Breast hypoplasia (HP:0003187)3.64470359
15Pili torti (HP:0003777)3.53305948
16Ileus (HP:0002595)3.46871948
17Shawl scrotum (HP:0000049)3.46582279
18Bronchitis (HP:0012387)3.39651109
19Onycholysis (HP:0001806)3.27916521
20Male infertility (HP:0003251)3.22718578
21Recurrent otitis media (HP:0000403)3.03156602
22Rectal prolapse (HP:0002035)3.02408503
23Ventricular fibrillation (HP:0001663)3.00177070
24Milia (HP:0001056)2.97554781
25Occipital encephalocele (HP:0002085)2.96065761
26Fragile nails (HP:0001808)2.95010172
27Curly hair (HP:0002212)2.89908450
28Woolly hair (HP:0002224)2.88814654
29Recurrent sinusitis (HP:0011108)2.75917960
30Amelogenesis imperfecta (HP:0000705)2.75481191
31Chronic sinusitis (HP:0011109)2.71058354
32Biliary tract neoplasm (HP:0100574)2.70715352
33Absent radius (HP:0003974)2.70096109
34Malnutrition (HP:0004395)2.67137679
35Micronodular cirrhosis (HP:0001413)2.66771264
36True hermaphroditism (HP:0010459)2.65838351
37Cystic liver disease (HP:0006706)2.64851996
38Pancreatic fibrosis (HP:0100732)2.60527951
39Aplasia involving forearm bones (HP:0009822)2.58417221
40Absent forearm bone (HP:0003953)2.58417221
41Aplasia/hypoplasia of the humerus (HP:0006507)2.51979274
42Decreased circulating renin level (HP:0003351)2.48640955
43Nail dystrophy (HP:0008404)2.47545870
44Concave nail (HP:0001598)2.47539135
45Colon cancer (HP:0003003)2.46180153
46Abnormality of the 1st metacarpal (HP:0010009)2.45978509
47Abnormality of permanent molar morphology (HP:0011071)2.43148978
48Abnormality of the dental root (HP:0006486)2.43148978
49Taurodontia (HP:0000679)2.43148978
50Short humerus (HP:0005792)2.42043501
51Chromsome breakage (HP:0040012)2.41488367
52Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.40174290
53Short 1st metacarpal (HP:0010034)2.40174290
54Ventricular tachycardia (HP:0004756)2.38833011
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.36422711
56Abnormal biliary tract morphology (HP:0012440)2.34863503
57Trismus (HP:0000211)2.33801933
58Atelectasis (HP:0100750)2.32462067
59Birth length less than 3rd percentile (HP:0003561)2.29526976
60Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.28813399
61Plantar hyperkeratosis (HP:0007556)2.28186591
62Syncope (HP:0001279)2.27852694
63Pancreatic cysts (HP:0001737)2.27842232
64Premature ovarian failure (HP:0008209)2.26714907
65Abnormality of renin-angiotensin system (HP:0000847)2.26282858
66Ependymoma (HP:0002888)2.26222798
67Facial hemangioma (HP:0000329)2.26038793
68Abnormality of the dental pulp (HP:0006479)2.25109777
69Abnormality of monocarboxylic acid metabolism (HP:0010996)2.24258926
70Flat acetabular roof (HP:0003180)2.21134333
71Abnormality of the gastric mucosa (HP:0004295)2.21002226
72Abnormality of the distal phalanges of the toes (HP:0010182)2.19702679
73Carpal bone hypoplasia (HP:0001498)2.19676024
74Bundle branch block (HP:0011710)2.19039370
75Abnormality of molar (HP:0011077)2.18100935
76Abnormality of molar morphology (HP:0011070)2.18100935
77Pustule (HP:0200039)2.17937623
78Ureteral duplication (HP:0000073)2.17889838
79Tubulointerstitial nephritis (HP:0001970)2.16016475
80Malignant gastrointestinal tract tumors (HP:0006749)2.15837847
81Gastrointestinal carcinoma (HP:0002672)2.15837847
82Multiple enchondromatosis (HP:0005701)2.15224171
83Fibular aplasia (HP:0002990)2.14396912
84Villous atrophy (HP:0011473)2.13616679
85Abnormality of small intestinal villus morphology (HP:0011472)2.13616679
86Cortical dysplasia (HP:0002539)2.13001123
87Natal tooth (HP:0000695)2.11623065
88Microretrognathia (HP:0000308)2.11080852
89Atrophic scars (HP:0001075)2.10424949
90Lip pit (HP:0100267)2.06135198
91Astrocytoma (HP:0009592)2.04896657
92Abnormality of the astrocytes (HP:0100707)2.04896657
93Abnormality of the aortic arch (HP:0012303)2.04034565
94Esophageal atresia (HP:0002032)2.03960087
95Hyperactive renin-angiotensin system (HP:0000841)2.03247460
96Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.03185776
97Pterygium (HP:0001059)2.02542791
98Aplasia/Hypoplasia of the breasts (HP:0010311)2.02413365
99Abnormality of the labia minora (HP:0012880)2.02035128
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.6380151
101Abnormal pancreas size (HP:0012094)1.98058195
102Focal segmental glomerulosclerosis (HP:0000097)1.96455950
103Abnormal hair laboratory examination (HP:0003328)1.96447773
104Breast aplasia (HP:0100783)1.95318118
105Uterine neoplasm (HP:0010784)1.94480188
106Renal salt wasting (HP:0000127)1.93823213
107Advanced eruption of teeth (HP:0006288)1.91061650
108Anal stenosis (HP:0002025)1.90512375
109Chronic hepatic failure (HP:0100626)1.89484948
110Bifid scrotum (HP:0000048)1.88081211
111Blepharitis (HP:0000498)1.86500694
112Abnormality of the umbilical cord (HP:0010881)1.85906033
113Polycythemia (HP:0001901)1.84799786
114Hyperaldosteronism (HP:0000859)1.84448181
115Hypoplastic labia majora (HP:0000059)1.82939814
116Postaxial foot polydactyly (HP:0001830)1.82570996
117Patellar aplasia (HP:0006443)1.81665278
118Abnormal blistering of the skin (HP:0008066)1.81504793
119Abnormality of midbrain morphology (HP:0002418)1.81218800
120Molar tooth sign on MRI (HP:0002419)1.81218800
121Secondary amenorrhea (HP:0000869)1.79601494
122Rough bone trabeculation (HP:0100670)1.78925323
123Abnormality of chloride homeostasis (HP:0011422)1.78672207
124Aplasia/Hypoplasia of the patella (HP:0006498)1.78329330
125Short phalanx of the thumb (HP:0009660)1.77978434
126Vascular calcification (HP:0004934)1.77968168
127Gout (HP:0001997)1.75752544
128Abnormality of the labia majora (HP:0012881)1.75422001
129Nephronophthisis (HP:0000090)1.74994564
130Abnormality of nail color (HP:0100643)1.74762268
131Hyperkalemia (HP:0002153)1.74466407
132Fused cervical vertebrae (HP:0002949)1.74032112
133Rib fusion (HP:0000902)1.72764745
134Bell-shaped thorax (HP:0001591)1.71224738
135Short thumb (HP:0009778)1.71190116
136Abnormality of the preputium (HP:0100587)1.69860418
137Tubular atrophy (HP:0000092)1.69544832
138Glomerulosclerosis (HP:0000096)1.68577947
139Abnormal umbilical cord blood vessels (HP:0011403)1.68057092
140Single umbilical artery (HP:0001195)1.68057092
141Abnormality of the fetal cardiovascular system (HP:0010948)1.68057092
142Alopecia of scalp (HP:0002293)1.67786860
143Angiofibromas (HP:0010615)1.67716075
144Adenoma sebaceum (HP:0009720)1.67716075
145Aplasia/Hypoplasia of the ulna (HP:0006495)1.67590707
146Selective tooth agenesis (HP:0001592)1.66323007
147Furrowed tongue (HP:0000221)1.65211612
148Ventricular arrhythmia (HP:0004308)1.64797146
149Hypoplasia of dental enamel (HP:0006297)1.63381411
150Neoplasm of the pancreas (HP:0002894)1.63295468
151Popliteal pterygium (HP:0009756)1.63275198
152Male pseudohermaphroditism (HP:0000037)1.57684753
153Short nail (HP:0001799)1.56162960
154Bilateral sensorineural hearing impairment (HP:0008619)1.54886670
155Anencephaly (HP:0002323)1.52339757
156Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.52249303
157Spinal cord compression (HP:0002176)1.50971830
158Broad distal phalanx of finger (HP:0009836)1.48344555
159Aplasia/Hypoplasia of the tongue (HP:0010295)1.47327253
160Chronic otitis media (HP:0000389)1.47147506
161Hypokalemic alkalosis (HP:0001949)1.46908600
162Aplasia/Hypoplasia of the spleen (HP:0010451)1.44087987
163Renal tubular acidosis (HP:0001947)1.43935769
164Abnormality of glutamine family amino acid metabolism (HP:0010902)1.43452125
165Median cleft lip (HP:0000161)1.41931980
166Broad face (HP:0000283)1.41328967
167Dehydration (HP:0001944)1.39578225
168Facial cleft (HP:0002006)1.38942877
169Hyperglycinuria (HP:0003108)1.38712769
170Cone-rod dystrophy (HP:0000548)1.37780800
171Abnormality of the renal medulla (HP:0100957)1.37627691
172Cardiovascular calcification (HP:0011915)1.37601502
173Abnormal ventriculo-arterial connection (HP:0011563)1.37486556
174Transposition of the great arteries (HP:0001669)1.37486556
175Abnormal connection of the cardiac segments (HP:0011545)1.37486556
176Asplenia (HP:0001746)1.36338047
177Preaxial hand polydactyly (HP:0001177)1.32880419
178Hydroxyprolinuria (HP:0003080)1.32290113
179Abnormality of proline metabolism (HP:0010907)1.32290113
180Sclerocornea (HP:0000647)1.31685727
181Bronchomalacia (HP:0002780)1.30846904
182Hyponatremia (HP:0002902)1.30514902
183Oculomotor apraxia (HP:0000657)1.30214128
184Hypoplasia of the uterus (HP:0000013)1.29015982
185Oligodontia (HP:0000677)1.28540561
186Stage 5 chronic kidney disease (HP:0003774)1.28352948
187Abnormality of the nasal septum (HP:0000419)1.28087091
188Congenital hepatic fibrosis (HP:0002612)1.27584773
189Septate vagina (HP:0001153)1.27495333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.73085967
2LATS14.00608743
3STK393.67447605
4LATS23.30605171
5WNK43.07096889
6SMG12.60162819
7FRK2.56598553
8STK38L2.47659561
9MST42.41679284
10MST1R2.29579293
11TTK2.18406661
12RPS6KB22.04021670
13CDK121.96166714
14MAP3K91.94440307
15EPHB21.94130216
16LMTK21.90174284
17PRKCI1.88101828
18MAP3K61.84565128
19WEE11.79709257
20MARK11.79022708
21TAOK11.77076452
22AKT31.70152136
23PRKD31.69909094
24MAP2K21.66626941
25FER1.66153257
26OXSR11.65458559
27PBK1.61738051
28NEK61.52230804
29STK31.45892229
30MAPKAPK31.45207825
31SIK11.44746049
32NEK21.35854374
33MET1.29026983
34KSR21.25647895
35NEK11.22007014
36DMPK1.20869763
37CHEK21.17555162
38NME11.14643565
39EEF2K1.12917358
40PTK21.12289057
41MAP3K21.09633114
42PLK11.05908457
43ALK1.05902999
44MAP3K81.05130329
45PLK41.04635461
46DYRK21.04255093
47STK101.02448193
48CDC71.00789949
49MAP3K121.00394398
50AURKB0.98361469
51CDK70.97134184
52PDK40.96614512
53PDK30.96614512
54PRKG20.94907673
55BUB10.89839098
56TYRO30.87394867
57PKN20.86704339
58TRPM70.84491053
59PDK20.82219976
60TRIB30.80631012
61AURKA0.79830824
62STK380.79750771
63PAK40.77566623
64PNCK0.76768887
65ICK0.76138233
66MELK0.72668981
67GRK10.71177178
68MAP2K10.68677149
69IRAK30.68032340
70EIF2AK30.66439343
71DDR20.65947585
72MTOR0.63440321
73MAP2K60.63056989
74MAP3K110.61942860
75PLK30.61310810
76AKT20.60840473
77EIF2AK10.60515980
78MAPK150.59322988
79PDPK10.58882752
80MAP3K70.58857324
81NUAK10.57176430
82RIPK10.56953624
83CDK90.54825065
84PRKAA10.54523899
85DYRK30.54165925
86MARK20.53687179
87MAP3K30.52998574
88ERBB40.52793648
89TSSK60.51818387
90CDK60.51384303
91PAK30.50543317
92CSNK1E0.50309288
93STK240.50189408
94PAK20.49354968
95MAP3K130.49064678
96CAMK1G0.49060739
97PAK10.48865007
98STK110.47073018
99PTK60.46211984
100EPHB10.45483026
101TESK10.44231289
102CHEK10.44207950
103BCR0.44111870
104PIM20.43108803
105NME20.42673947
106ARAF0.41005673
107TAOK30.40538362
108CDK40.38228152
109BMX0.37807646
110CAMK2G0.36401994
111CSNK1D0.35792731
112ABL20.35235211
113DAPK10.34391623
114PRKCZ0.34071941
115ERBB20.33843603
116CDK20.33535602
117CDK80.33152713
118RPS6KA10.32491782
119KSR10.32177740
120SCYL20.29272270
121PRKD20.29003134
122CAMK1D0.27360357
123TIE10.26704448
124TAF10.25446232
125MUSK0.25192119
126PAK60.24910091
127VRK20.24197326
128PRKAA20.23726047
129DAPK20.22824073
130LRRK20.22791713
131BRSK20.22299616
132RAF10.21795599
133ILK0.21511690
134BRSK10.21372739
135MAPKAPK50.16747106
136RPS6KA20.16296942
137ACVR1B0.16292108
138CAMK2D0.15821412
139PTK2B0.15767623
140NTRK10.15549845
141CHUK0.14239773

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003603.42015216
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.18376687
3Fat digestion and absorption_Homo sapiens_hsa049752.88297820
4Tight junction_Homo sapiens_hsa045302.80126591
5Mineral absorption_Homo sapiens_hsa049782.64149593
6Chemical carcinogenesis_Homo sapiens_hsa052042.54489614
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.50949311
8Hippo signaling pathway_Homo sapiens_hsa043902.44598505
9Adherens junction_Homo sapiens_hsa045202.26016056
10RNA transport_Homo sapiens_hsa030132.04582834
11Tyrosine metabolism_Homo sapiens_hsa003502.04487162
12Caffeine metabolism_Homo sapiens_hsa002322.02868916
13Cell cycle_Homo sapiens_hsa041101.99867312
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.99365619
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.93987737
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.92626135
17beta-Alanine metabolism_Homo sapiens_hsa004101.92303998
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.90982222
19Renin-angiotensin system_Homo sapiens_hsa046141.79313778
20Protein digestion and absorption_Homo sapiens_hsa049741.71819199
21p53 signaling pathway_Homo sapiens_hsa041151.65953384
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59462425
23Glutathione metabolism_Homo sapiens_hsa004801.58410724
24Vitamin digestion and absorption_Homo sapiens_hsa049771.56064523
25Fructose and mannose metabolism_Homo sapiens_hsa000511.55013611
26Retinol metabolism_Homo sapiens_hsa008301.51328861
27Small cell lung cancer_Homo sapiens_hsa052221.49535219
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49390443
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48938906
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48156132
31TGF-beta signaling pathway_Homo sapiens_hsa043501.45684780
32Bladder cancer_Homo sapiens_hsa052191.44725522
33Folate biosynthesis_Homo sapiens_hsa007901.39857493
34Glycerolipid metabolism_Homo sapiens_hsa005611.33532692
35Oocyte meiosis_Homo sapiens_hsa041141.32641107
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32157959
37Basal cell carcinoma_Homo sapiens_hsa052171.30978861
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.30221891
39Galactose metabolism_Homo sapiens_hsa000521.29817901
40Arginine biosynthesis_Homo sapiens_hsa002201.29161126
41Thyroid cancer_Homo sapiens_hsa052161.28815091
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27539448
43Pancreatic secretion_Homo sapiens_hsa049721.26509564
44Linoleic acid metabolism_Homo sapiens_hsa005911.26285840
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23773740
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.20485372
47ABC transporters_Homo sapiens_hsa020101.18350747
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15722146
49Glycerophospholipid metabolism_Homo sapiens_hsa005641.14338520
50Circadian rhythm_Homo sapiens_hsa047101.13998585
51Hedgehog signaling pathway_Homo sapiens_hsa043401.12160228
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11271937
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08354917
54RNA polymerase_Homo sapiens_hsa030201.07198578
55MicroRNAs in cancer_Homo sapiens_hsa052061.06990742
56N-Glycan biosynthesis_Homo sapiens_hsa005101.06609130
57Starch and sucrose metabolism_Homo sapiens_hsa005001.04266530
58Endometrial cancer_Homo sapiens_hsa052131.03620017
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02681276
60Fatty acid biosynthesis_Homo sapiens_hsa000611.02585173
61Arachidonic acid metabolism_Homo sapiens_hsa005901.02395685
62Fanconi anemia pathway_Homo sapiens_hsa034601.00083264
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99365861
64Mismatch repair_Homo sapiens_hsa034300.97447839
65Fatty acid degradation_Homo sapiens_hsa000710.96871563
66Selenocompound metabolism_Homo sapiens_hsa004500.96650520
67Pyruvate metabolism_Homo sapiens_hsa006200.93147812
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.93107022
69mTOR signaling pathway_Homo sapiens_hsa041500.91866434
70Vitamin B6 metabolism_Homo sapiens_hsa007500.91272010
71Basal transcription factors_Homo sapiens_hsa030220.90651211
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90516451
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89240441
74Sphingolipid metabolism_Homo sapiens_hsa006000.87495947
75Homologous recombination_Homo sapiens_hsa034400.87098742
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86043302
77Arginine and proline metabolism_Homo sapiens_hsa003300.84686986
78mRNA surveillance pathway_Homo sapiens_hsa030150.84578555
79Wnt signaling pathway_Homo sapiens_hsa043100.84566831
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84533048
81Colorectal cancer_Homo sapiens_hsa052100.83636456
82VEGF signaling pathway_Homo sapiens_hsa043700.81825256
83Proteasome_Homo sapiens_hsa030500.81801348
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80224874
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80081621
86DNA replication_Homo sapiens_hsa030300.77026756
87Renal cell carcinoma_Homo sapiens_hsa052110.76645327
88ECM-receptor interaction_Homo sapiens_hsa045120.75583919
89Huntingtons disease_Homo sapiens_hsa050160.74484050
90Dorso-ventral axis formation_Homo sapiens_hsa043200.74223994
91Pathways in cancer_Homo sapiens_hsa052000.72113261
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70343013
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.70219890
94Tryptophan metabolism_Homo sapiens_hsa003800.69765585
95Sulfur metabolism_Homo sapiens_hsa009200.69664014
96Ether lipid metabolism_Homo sapiens_hsa005650.68220988
97GnRH signaling pathway_Homo sapiens_hsa049120.66019129
98Proteoglycans in cancer_Homo sapiens_hsa052050.65228486
99Choline metabolism in cancer_Homo sapiens_hsa052310.64764878
100Focal adhesion_Homo sapiens_hsa045100.63669950
101Collecting duct acid secretion_Homo sapiens_hsa049660.63170601
102Vibrio cholerae infection_Homo sapiens_hsa051100.61754038
103Inositol phosphate metabolism_Homo sapiens_hsa005620.61594860
104Peroxisome_Homo sapiens_hsa041460.61384725
105Pancreatic cancer_Homo sapiens_hsa052120.60995911
106Hepatitis C_Homo sapiens_hsa051600.59003168
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58848679
108RNA degradation_Homo sapiens_hsa030180.57991963
109Regulation of autophagy_Homo sapiens_hsa041400.57459563
110Ovarian steroidogenesis_Homo sapiens_hsa049130.57023410
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56585896
112Prostate cancer_Homo sapiens_hsa052150.56389193
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56255556
114Sulfur relay system_Homo sapiens_hsa041220.54722102
115Insulin resistance_Homo sapiens_hsa049310.54697800
116Pyrimidine metabolism_Homo sapiens_hsa002400.54451633
117Metabolic pathways_Homo sapiens_hsa011000.54429963
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.53938025
119Notch signaling pathway_Homo sapiens_hsa043300.53857646
120Biosynthesis of amino acids_Homo sapiens_hsa012300.53755810
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52233142
122Pentose phosphate pathway_Homo sapiens_hsa000300.51940795
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51321466
124Thyroid hormone synthesis_Homo sapiens_hsa049180.50252028
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49812647
126Estrogen signaling pathway_Homo sapiens_hsa049150.48594015
127Salivary secretion_Homo sapiens_hsa049700.48564883
128Base excision repair_Homo sapiens_hsa034100.48441770
129ErbB signaling pathway_Homo sapiens_hsa040120.48039054
130Bile secretion_Homo sapiens_hsa049760.47630661
131Spliceosome_Homo sapiens_hsa030400.47490047
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46633228
133Nucleotide excision repair_Homo sapiens_hsa034200.46220493
134Melanoma_Homo sapiens_hsa052180.46011471
135FoxO signaling pathway_Homo sapiens_hsa040680.45218807
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43366932
137AMPK signaling pathway_Homo sapiens_hsa041520.43265179
138Amoebiasis_Homo sapiens_hsa051460.43192335
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42678982
140Histidine metabolism_Homo sapiens_hsa003400.40507342
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40156363
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39769969
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39703833
144Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38432275
145Lysine degradation_Homo sapiens_hsa003100.37620309
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.36159779
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35576925
148Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35535471
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35503214
150Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33862760
151Steroid biosynthesis_Homo sapiens_hsa001000.32974476
152Insulin signaling pathway_Homo sapiens_hsa049100.31406854

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