USP45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.13222884
2nuclear pore organization (GO:0006999)4.96251091
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.39043155
4positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.28440872
5positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.28440872
6positive regulation of mitotic sister chromatid separation (GO:1901970)4.28440872
7neuronal action potential propagation (GO:0019227)4.22222973
8chromatin remodeling at centromere (GO:0031055)4.21287118
9CENP-A containing nucleosome assembly (GO:0034080)4.18526958
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.16628845
11L-amino acid import (GO:0043092)4.04589516
12ionotropic glutamate receptor signaling pathway (GO:0035235)3.98134316
13chemosensory behavior (GO:0007635)3.96252556
14synaptic vesicle maturation (GO:0016188)3.92393462
15detection of calcium ion (GO:0005513)3.87560471
16protein localization to kinetochore (GO:0034501)3.84157198
17vocalization behavior (GO:0071625)3.83836802
18mitotic metaphase plate congression (GO:0007080)3.83157283
19DNA double-strand break processing (GO:0000729)3.83047939
20regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.83026059
21regulation of mitotic metaphase/anaphase transition (GO:0030071)3.83026059
22ribosome assembly (GO:0042255)3.80908705
23mitotic sister chromatid cohesion (GO:0007064)3.80418690
24protein targeting to Golgi (GO:0000042)3.77829878
25negative regulation of DNA-dependent DNA replication (GO:2000104)3.77489926
26replication fork processing (GO:0031297)3.77286995
27locomotory exploration behavior (GO:0035641)3.75353577
28glutamate receptor signaling pathway (GO:0007215)3.73174439
29regulation of sister chromatid segregation (GO:0033045)3.72901128
30regulation of mitotic sister chromatid separation (GO:0010965)3.72901128
31regulation of mitotic sister chromatid segregation (GO:0033047)3.72901128
32regulation of synaptic vesicle exocytosis (GO:2000300)3.72874540
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.72301958
34regulation of centriole replication (GO:0046599)3.72148775
35regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.67246888
36metaphase plate congression (GO:0051310)3.63858389
37DNA replication checkpoint (GO:0000076)3.61318580
38regulation of mitotic spindle checkpoint (GO:1903504)3.61049535
39regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.61049535
40pore complex assembly (GO:0046931)3.60394831
41histone exchange (GO:0043486)3.58566942
42negative regulation of mitotic sister chromatid separation (GO:2000816)3.57909391
43negative regulation of sister chromatid segregation (GO:0033046)3.57909391
44negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.57909391
45negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.57909391
46negative regulation of mitotic sister chromatid segregation (GO:0033048)3.57909391
47establishment of integrated proviral latency (GO:0075713)3.57571401
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.57290824
49spindle checkpoint (GO:0031577)3.55889335
50negative regulation of chromosome segregation (GO:0051985)3.55285990
51mitotic G2/M transition checkpoint (GO:0044818)3.54692436
52regulation of glutamate receptor signaling pathway (GO:1900449)3.53408582
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.53122548
54inner ear receptor cell development (GO:0060119)3.49884952
55mitotic spindle checkpoint (GO:0071174)3.46855484
56positive regulation of chromosome segregation (GO:0051984)3.45567347
57positive regulation of fibroblast migration (GO:0010763)3.43712036
58kinetochore organization (GO:0051383)3.43185274
59establishment of chromosome localization (GO:0051303)3.40066591
60neuron-neuron synaptic transmission (GO:0007270)3.38788411
61purine nucleobase biosynthetic process (GO:0009113)3.37536307
62cerebellar Purkinje cell differentiation (GO:0021702)3.37533255
63protein localization to chromosome, centromeric region (GO:0071459)3.36164234
64retrograde transport, vesicle recycling within Golgi (GO:0000301)3.34607276
65regulation of helicase activity (GO:0051095)3.34175532
66attachment of spindle microtubules to kinetochore (GO:0008608)3.33314765
67synaptic transmission, glutamatergic (GO:0035249)3.31568002
68DNA replication-independent nucleosome assembly (GO:0006336)3.29597878
69DNA replication-independent nucleosome organization (GO:0034724)3.29597878
70mitotic spindle assembly checkpoint (GO:0007094)3.27321178
71DNA replication-dependent nucleosome assembly (GO:0006335)3.27283358
72DNA replication-dependent nucleosome organization (GO:0034723)3.27283358
73spindle assembly checkpoint (GO:0071173)3.26105367
74proteasome assembly (GO:0043248)3.25019888
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.24567037
76kinetochore assembly (GO:0051382)3.24223356
77synaptic vesicle exocytosis (GO:0016079)3.23215257
78establishment of protein localization to Golgi (GO:0072600)3.21720075
79transmission of nerve impulse (GO:0019226)3.21079941
80prenylation (GO:0097354)3.19856065
81protein prenylation (GO:0018342)3.19856065
82regulation of excitatory postsynaptic membrane potential (GO:0060079)3.18232173
83regulation of chromosome segregation (GO:0051983)3.17687609
84regulation of DNA endoreduplication (GO:0032875)3.16819536
85synaptic vesicle endocytosis (GO:0048488)3.16774111
86startle response (GO:0001964)3.16696884
87C4-dicarboxylate transport (GO:0015740)3.15879249
88mitotic nuclear envelope disassembly (GO:0007077)3.15558156
89negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13136727
90positive regulation of histone H3-K4 methylation (GO:0051571)3.12276587
91vesicle transport along microtubule (GO:0047496)3.12092048
92sister chromatid segregation (GO:0000819)3.11847451
93protein localization to synapse (GO:0035418)3.11759599
94histone mRNA metabolic process (GO:0008334)3.09682653
95double-strand break repair via nonhomologous end joining (GO:0006303)3.08782324
96non-recombinational repair (GO:0000726)3.08782324
97glutamate secretion (GO:0014047)3.08289192
98regulation of synaptic vesicle transport (GO:1902803)3.07833439
99synapsis (GO:0007129)3.07269272
100IMP biosynthetic process (GO:0006188)3.07227241
101long-term memory (GO:0007616)3.07208237
102cAMP catabolic process (GO:0006198)3.04367186
103monoubiquitinated protein deubiquitination (GO:0035520)3.03935959
104regulation of long-term neuronal synaptic plasticity (GO:0048169)3.03728403
105response to X-ray (GO:0010165)3.02723123
106mitotic G2 DNA damage checkpoint (GO:0007095)3.02122863
107mitotic sister chromatid segregation (GO:0000070)3.01894602
108cyclic nucleotide catabolic process (GO:0009214)3.01020838
109long term synaptic depression (GO:0060292)3.00043799
110long-term synaptic potentiation (GO:0060291)2.99439225
111negative regulation of cell killing (GO:0031342)2.99179526
112negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.99179526
113maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.97742558
114NLS-bearing protein import into nucleus (GO:0006607)2.97695491
115regulation of centrosome cycle (GO:0046605)2.97220661
116negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.97045053
117negative regulation of T-helper cell differentiation (GO:0045623)2.97045053
118amino acid import (GO:0043090)2.96892348
119negative regulation of DNA recombination (GO:0045910)2.96716914
120regulation of postsynaptic membrane potential (GO:0060078)2.96534799
121regulation of meiosis I (GO:0060631)2.94810413
122nuclear envelope disassembly (GO:0051081)2.94289619
123membrane disassembly (GO:0030397)2.94289619
124somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.94141125
125isotype switching (GO:0045190)2.94141125
126somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.94141125
127regulation of mitotic spindle organization (GO:0060236)2.93952269
128postreplication repair (GO:0006301)2.92728215
129nucleobase biosynthetic process (GO:0046112)2.92564530
130microtubule anchoring (GO:0034453)2.91843164
131negative regulation of DNA repair (GO:0045738)2.90608747
132IMP metabolic process (GO:0046040)2.90318516
133negative regulation of mitosis (GO:0045839)2.90271696
134neuron cell-cell adhesion (GO:0007158)2.89166900
135maturation of 5.8S rRNA (GO:0000460)2.88639202
136regulation of neuronal synaptic plasticity (GO:0048168)2.87737783
137neurotransmitter secretion (GO:0007269)2.87414759
138exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.81695535
139G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81385541
140regulation of ARF protein signal transduction (GO:0032012)2.81206513
141innervation (GO:0060384)2.80648970
142membrane depolarization during action potential (GO:0086010)2.80564017
143regulation of centrosome duplication (GO:0010824)2.79256446
144membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.79119441
145histone-serine phosphorylation (GO:0035404)2.78007531
146regulation of dendritic spine morphogenesis (GO:0061001)2.77540548
147RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.76586597
148presynaptic membrane assembly (GO:0097105)2.76460492
149response to histamine (GO:0034776)2.76396928
150regulation of synaptic transmission, glutamatergic (GO:0051966)2.75677674
151double-strand break repair via homologous recombination (GO:0000724)2.75430811
152negative regulation of B cell mediated immunity (GO:0002713)2.74890144
153negative regulation of immunoglobulin mediated immune response (GO:0002890)2.74890144
154centriole replication (GO:0007099)2.74333695
155synaptic vesicle docking involved in exocytosis (GO:0016081)2.74143243
156recombinational repair (GO:0000725)2.73678276
157dicarboxylic acid biosynthetic process (GO:0043650)2.73227056
158exploration behavior (GO:0035640)2.73018523
159regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72494925
160mitochondrial RNA metabolic process (GO:0000959)2.71810509
161regulation of synaptic plasticity (GO:0048167)2.71475968
162positive regulation of membrane potential (GO:0045838)2.70775373
163nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70762795
164somatic recombination of immunoglobulin gene segments (GO:0016447)2.70739648
165folic acid-containing compound biosynthetic process (GO:0009396)2.68627975
166striatum development (GO:0021756)2.68424021
167regulation of histone H3-K9 methylation (GO:0051570)2.67926191
168peptidyl-histidine modification (GO:0018202)2.67824061
169regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.66046089
170histone H2A acetylation (GO:0043968)2.65949800
171regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.61914628
172suckling behavior (GO:0001967)2.61582029
173behavioral defense response (GO:0002209)2.61286726
174behavioral fear response (GO:0001662)2.61286726
175regulation of respiratory system process (GO:0044065)2.60808481
176membrane depolarization (GO:0051899)2.59288177
177righting reflex (GO:0060013)2.58971892
178auditory behavior (GO:0031223)2.58962350
179pre-miRNA processing (GO:0031054)2.58346394
180positive regulation of synaptic transmission, GABAergic (GO:0032230)2.58251483
181ER overload response (GO:0006983)2.57445279
182dendrite morphogenesis (GO:0048813)2.57387894
183proline transport (GO:0015824)2.56899207
184glycosphingolipid biosynthetic process (GO:0006688)2.56791437
185neuromuscular process controlling balance (GO:0050885)2.56628097
186regulation of synaptic transmission, GABAergic (GO:0032228)2.55666239
187regulation of clathrin-mediated endocytosis (GO:2000369)2.55244034
188negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.54032958
189regulation of cAMP-dependent protein kinase activity (GO:2000479)2.53318222
190activation of protein kinase A activity (GO:0034199)2.52856557
191behavioral response to ethanol (GO:0048149)2.50215166
192neurotransmitter transport (GO:0006836)2.48743133
193learning (GO:0007612)2.47682235
194negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.45239181
195insulin secretion (GO:0030073)2.44235547
196regulation of neurotransmitter secretion (GO:0046928)2.43542833
197fear response (GO:0042596)2.43462136
198regulation of germinal center formation (GO:0002634)2.42631077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.57650377
2EZH2_22144423_ChIP-Seq_EOC_Human4.52649548
3GBX2_23144817_ChIP-Seq_PC3_Human3.89634009
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.83892824
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.28443872
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91521837
7ELK1_19687146_ChIP-ChIP_HELA_Human2.52371576
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.51966058
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.48652310
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.47380986
11SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.42072623
12TAF15_26573619_Chip-Seq_HEK293_Human2.28169202
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.23812385
14* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23125752
15IGF1R_20145208_ChIP-Seq_DFB_Human2.22822680
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18630056
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15851137
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.13606359
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.13492541
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09688187
21* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07422733
22SMAD4_21799915_ChIP-Seq_A2780_Human2.02710315
23AR_21909140_ChIP-Seq_LNCAP_Human2.01557192
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.98052048
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95767982
26P300_19829295_ChIP-Seq_ESCs_Human1.92777830
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.91209269
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90588767
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88809515
30FUS_26573619_Chip-Seq_HEK293_Human1.87473433
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85274768
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83898810
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.82948772
34STAT3_23295773_ChIP-Seq_U87_Human1.81530846
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80098250
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79588458
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79465055
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79388106
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.79126456
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76082470
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73843434
42REST_21632747_ChIP-Seq_MESCs_Mouse1.73835921
43VDR_23849224_ChIP-Seq_CD4+_Human1.72674258
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.72123821
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71940207
46AR_21572438_ChIP-Seq_LNCaP_Human1.69669717
47TP53_16413492_ChIP-PET_HCT116_Human1.69131414
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69044845
49DROSHA_22980978_ChIP-Seq_HELA_Human1.68819556
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.66352246
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66249614
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65110512
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.64465248
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.62417425
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.61994993
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.59833812
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59617068
58TCF4_23295773_ChIP-Seq_U87_Human1.54334038
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54120826
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53074797
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52545905
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49149907
63ER_23166858_ChIP-Seq_MCF-7_Human1.49051073
64FOXP3_21729870_ChIP-Seq_TREG_Human1.48536554
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47014944
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.44333207
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44005757
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43975800
69VDR_22108803_ChIP-Seq_LS180_Human1.43886265
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.43478252
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41514304
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41155602
73ZNF274_21170338_ChIP-Seq_K562_Hela1.41126846
74EWS_26573619_Chip-Seq_HEK293_Human1.39883534
75EED_16625203_ChIP-ChIP_MESCs_Mouse1.38974268
76AR_25329375_ChIP-Seq_VCAP_Human1.38499367
77TP53_18474530_ChIP-ChIP_U2OS_Human1.38078416
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37620712
79EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37547467
80RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37547467
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.37183270
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36296002
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.36019596
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34943600
85SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34544791
86BCAT_22108803_ChIP-Seq_LS180_Human1.33858371
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32587188
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32406929
89AHR_22903824_ChIP-Seq_MCF-7_Human1.32173437
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32048761
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.29919679
92ETS1_20019798_ChIP-Seq_JURKAT_Human1.29850434
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29261546
94P53_22387025_ChIP-Seq_ESCs_Mouse1.28308610
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28244590
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27310017
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27089070
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.26404492
99RUNX2_22187159_ChIP-Seq_PCA_Human1.25074498
100* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.24348947
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.24105625
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.23500260
103GATA1_22025678_ChIP-Seq_K562_Human1.23452220
104MYC_18940864_ChIP-ChIP_HL60_Human1.23015850
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22956451
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22956451
107EZH2_27304074_Chip-Seq_ESCs_Mouse1.22519674
108JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21525805
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20548818
110MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20004730
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.19719139
112NANOG_16153702_ChIP-ChIP_HESCs_Human1.18884384
113* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16936660
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15973049
115* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14885717
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14019638
117SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13917719
118CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13831037
119RNF2_27304074_Chip-Seq_ESCs_Mouse1.13730897
120AR_19668381_ChIP-Seq_PC3_Human1.11337770
121IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11203393
122CBP_20019798_ChIP-Seq_JUKART_Human1.11203393
123DCP1A_22483619_ChIP-Seq_HELA_Human1.09464262
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09142961
125HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08996864
126NMYC_18555785_Chip-Seq_ESCs_Mouse1.08104719
127CRX_20693478_ChIP-Seq_RETINA_Mouse1.07935001
128P300_18555785_Chip-Seq_ESCs_Mouse1.07298374
129NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07186931
130RXR_22108803_ChIP-Seq_LS180_Human1.05796290
131FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05677993
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04768013
133EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04558202
134POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04347989
135SOX2_18555785_Chip-Seq_ESCs_Mouse1.02905933
136JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02646503
137STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02116013
138FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01570213
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01536336
140STAT3_18555785_Chip-Seq_ESCs_Mouse1.01516240
141TCF4_18268006_ChIP-ChIP_LS174T_Human1.01132957
142MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00132220
143SOX2_16153702_ChIP-ChIP_HESCs_Human1.00113467
144MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97771791
145CDX2_22108803_ChIP-Seq_LS180_Human0.97633597
146WT1_19549856_ChIP-ChIP_CCG9911_Human0.97505477
147* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96399944
148SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94597524
149MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92338934
150OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92272254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.69900939
2MP0008057_abnormal_DNA_replication5.64451769
3MP0003880_abnormal_central_pattern4.88620660
4MP0003890_abnormal_embryonic-extraembry3.82413083
5MP0003635_abnormal_synaptic_transmissio3.62757573
6MP0010094_abnormal_chromosome_stability3.41971165
7MP0004270_analgesia3.31232193
8MP0008058_abnormal_DNA_repair3.28490580
9MP0009745_abnormal_behavioral_response3.28487233
10MP0004957_abnormal_blastocyst_morpholog3.17517229
11MP0000569_abnormal_digit_pigmentation3.07833302
12MP0003718_maternal_effect2.92911447
13MP0001968_abnormal_touch/_nociception2.92789391
14MP0002063_abnormal_learning/memory/cond2.88676173
15MP0003787_abnormal_imprinting2.75221275
16MP0003941_abnormal_skin_development2.70905982
17MP0002064_seizures2.69309292
18MP0008877_abnormal_DNA_methylation2.54620847
19MP0003077_abnormal_cell_cycle2.53736688
20MP0003693_abnormal_embryo_hatching2.53137828
21MP0005645_abnormal_hypothalamus_physiol2.51304992
22MP0003111_abnormal_nucleus_morphology2.50700583
23MP0008007_abnormal_cellular_replicative2.46305070
24MP0009046_muscle_twitch2.46282411
25MP0002009_preneoplasia2.41485605
26MP0009780_abnormal_chondrocyte_physiolo2.40453483
27MP0005646_abnormal_pituitary_gland2.39282475
28MP0002735_abnormal_chemical_nociception2.34446559
29MP0001188_hyperpigmentation2.34096162
30MP0002572_abnormal_emotion/affect_behav2.33406136
31MP0002736_abnormal_nociception_after2.31028838
32MP0001486_abnormal_startle_reflex2.26829208
33MP0002067_abnormal_sensory_capabilities2.14859929
34MP0002272_abnormal_nervous_system2.14843429
35MP0002822_catalepsy2.05707651
36MP0008932_abnormal_embryonic_tissue2.05542722
37MP0001293_anophthalmia2.05314225
38MP0005409_darkened_coat_color2.04037777
39MP0003937_abnormal_limbs/digits/tail_de2.03755475
40MP0010352_gastrointestinal_tract_polyps2.01599746
41MP0002734_abnormal_mechanical_nocicepti1.99445151
42MP0003045_fibrosis1.96412385
43MP0003283_abnormal_digestive_organ1.83454013
44MP0001501_abnormal_sleep_pattern1.78580099
45MP0004145_abnormal_muscle_electrophysio1.76527827
46MP0000015_abnormal_ear_pigmentation1.76146915
47MP0002139_abnormal_hepatobiliary_system1.74972036
48MP0005423_abnormal_somatic_nervous1.74902243
49MP0001440_abnormal_grooming_behavior1.74180360
50MP0008569_lethality_at_weaning1.69862902
51MP0010386_abnormal_urinary_bladder1.61559250
52MP0001730_embryonic_growth_arrest1.59788153
53MP0002084_abnormal_developmental_patter1.58847988
54MP0000383_abnormal_hair_follicle1.58003443
55MP0010678_abnormal_skin_adnexa1.55762405
56MP0001672_abnormal_embryogenesis/_devel1.55045504
57MP0005380_embryogenesis_phenotype1.55045504
58MP0005187_abnormal_penis_morphology1.52419593
59MP0002184_abnormal_innervation1.52018925
60MP0001697_abnormal_embryo_size1.50498222
61MP0002102_abnormal_ear_morphology1.49486105
62MP0002877_abnormal_melanocyte_morpholog1.48716989
63MP0003786_premature_aging1.46992845
64MP0004924_abnormal_behavior1.44256998
65MP0005386_behavior/neurological_phenoty1.44256998
66MP0005174_abnormal_tail_pigmentation1.43576421
67MP0004215_abnormal_myocardial_fiber1.43359533
68MP0002938_white_spotting1.42603582
69MP0002557_abnormal_social/conspecific_i1.42037164
70MP0006292_abnormal_olfactory_placode1.41775883
71MP0003984_embryonic_growth_retardation1.41707848
72MP0002088_abnormal_embryonic_growth/wei1.39918167
73MP0003121_genomic_imprinting1.37793329
74MP0000647_abnormal_sebaceous_gland1.37492719
75MP0004811_abnormal_neuron_physiology1.36787338
76MP0003567_abnormal_fetal_cardiomyocyte1.36638918
77MP0001970_abnormal_pain_threshold1.35684054
78MP0002733_abnormal_thermal_nociception1.35618961
79MP0006276_abnormal_autonomic_nervous1.34667017
80MP0002909_abnormal_adrenal_gland1.34034578
81MP0003633_abnormal_nervous_system1.29624908
82MP0003329_amyloid_beta_deposits1.29292776
83MP0001286_abnormal_eye_development1.28659105
84MP0005395_other_phenotype1.28624533
85MP0006035_abnormal_mitochondrial_morpho1.25962170
86MP0002638_abnormal_pupillary_reflex1.24505448
87MP0002697_abnormal_eye_size1.21999120
88MP0002085_abnormal_embryonic_tissue1.21826618
89MP0005171_absent_coat_pigmentation1.20192417
90MP0000372_irregular_coat_pigmentation1.20152046
91MP0001529_abnormal_vocalization1.18034702
92MP0004147_increased_porphyrin_level1.17507914
93MP0000350_abnormal_cell_proliferation1.16566512
94MP0003631_nervous_system_phenotype1.15502957
95MP0000778_abnormal_nervous_system1.15153124
96MP0003632_abnormal_nervous_system1.14928678
97MP0000955_abnormal_spinal_cord1.13477700
98MP0002066_abnormal_motor_capabilities/c1.11601067
99MP0003191_abnormal_cellular_cholesterol1.10642735
100MP0005076_abnormal_cell_differentiation1.10201458
101MP0002233_abnormal_nose_morphology1.08324000
102MP0003122_maternal_imprinting1.08116915
103MP0003136_yellow_coat_color1.07400358
104MP0001986_abnormal_taste_sensitivity1.06030288
105MP0000427_abnormal_hair_cycle1.05870931
106MP0001929_abnormal_gametogenesis1.05448893
107MP0002882_abnormal_neuron_morphology1.04886342
108MP0002160_abnormal_reproductive_system1.03897594
109MP0001177_atelectasis1.03358685
110MP0001661_extended_life_span1.03206676
111MP0006072_abnormal_retinal_apoptosis1.02519935
112MP0002693_abnormal_pancreas_physiology1.02299002
113MP0010234_abnormal_vibrissa_follicle1.01162900
114MP0002210_abnormal_sex_determination1.00181053
115MP0002086_abnormal_extraembryonic_tissu0.98497777
116MP0002234_abnormal_pharynx_morphology0.98271272
117MP0000631_abnormal_neuroendocrine_gland0.97557564
118MP0002152_abnormal_brain_morphology0.97283578
119MP0002751_abnormal_autonomic_nervous0.95712877
120MP0000653_abnormal_sex_gland0.90262105
121MP0002080_prenatal_lethality0.89859678
122MP0002229_neurodegeneration0.88452092
123MP0000428_abnormal_craniofacial_morphol0.88383284
124MP0010307_abnormal_tumor_latency0.87550994
125MP0006054_spinal_hemorrhage0.85364126
126MP0001145_abnormal_male_reproductive0.85359215
127MP0009703_decreased_birth_body0.84748886
128MP0004084_abnormal_cardiac_muscle0.83876535
129MP0004742_abnormal_vestibular_system0.82409171
130MP0001299_abnormal_eye_distance/0.82199508
131MP0002928_abnormal_bile_duct0.81261348
132MP0005408_hypopigmentation0.81031741
133MP0003879_abnormal_hair_cell0.80731679
134MP0002396_abnormal_hematopoietic_system0.79630748
135MP0001944_abnormal_pancreas_morphology0.79179955
136MP0005391_vision/eye_phenotype0.78692584
137MP0001963_abnormal_hearing_physiology0.78539991
138MP0004197_abnormal_fetal_growth/weight/0.78446308
139MP0002111_abnormal_tail_morphology0.77387246
140MP0003119_abnormal_digestive_system0.75680396
141MP0002069_abnormal_eating/drinking_beha0.75555680
142MP0001324_abnormal_eye_pigmentation0.75539124
143MP0003300_gastrointestinal_ulcer0.75325006
144MP0001984_abnormal_olfaction0.74688295
145MP0003935_abnormal_craniofacial_develop0.74527449
146MP0000432_abnormal_head_morphology0.74491418
147MP0005379_endocrine/exocrine_gland_phen0.73368675
148MP0002166_altered_tumor_susceptibility0.72373282
149MP0005551_abnormal_eye_electrophysiolog0.72252042
150MP0000358_abnormal_cell_content/0.70354092
151MP0004885_abnormal_endolymph0.70302732
152MP0008874_decreased_physiological_sensi0.68570598
153MP0003221_abnormal_cardiomyocyte_apopto0.68245373
154MP0005253_abnormal_eye_physiology0.68220096
155MP0009672_abnormal_birth_weight0.67801275
156MP0003943_abnormal_hepatobiliary_system0.67542160
157MP0002090_abnormal_vision0.67393017
158MP0009379_abnormal_foot_pigmentation0.67086004
159MP0005535_abnormal_body_temperature0.67009930
160MP0003868_abnormal_feces_composition0.66466194
161MP0003755_abnormal_palate_morphology0.66337309
162MP0003698_abnormal_male_reproductive0.66085986
163MP0002006_tumorigenesis0.65757182
164MP0004142_abnormal_muscle_tone0.64171193
165MP0001119_abnormal_female_reproductive0.64106735
166MP0000678_abnormal_parathyroid_gland0.64024148
167MP0008995_early_reproductive_senescence0.63868950
168MP0004133_heterotaxia0.63753256
169MP0003806_abnormal_nucleotide_metabolis0.62709395
170MP0004085_abnormal_heartbeat0.61953952
171MP0000313_abnormal_cell_death0.61872738
172MP0004484_altered_response_of0.61819094
173MP0009697_abnormal_copulation0.59732618
174MP0005310_abnormal_salivary_gland0.58434964
175MP0002837_dystrophic_cardiac_calcinosis0.58316278
176MP0000604_amyloidosis0.57897364
177MP0002177_abnormal_outer_ear0.57714708
178MP0005647_abnormal_sex_gland0.56877243
179MP0003861_abnormal_nervous_system0.56096256
180MP0002082_postnatal_lethality0.52311045
181MP0010770_preweaning_lethality0.52311045

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.33467429
2Focal seizures (HP:0007359)4.89796806
3Febrile seizures (HP:0002373)4.82740283
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.98680368
5Atonic seizures (HP:0010819)3.94135988
6Chromsome breakage (HP:0040012)3.90609472
7Dialeptic seizures (HP:0011146)3.67188259
8Abnormality of chromosome stability (HP:0003220)3.64630978
9Visual hallucinations (HP:0002367)3.58988022
10Epileptic encephalopathy (HP:0200134)3.52061260
11Absence seizures (HP:0002121)3.44501259
12Generalized tonic-clonic seizures (HP:0002069)3.42593368
13Impaired vibration sensation in the lower limbs (HP:0002166)3.34330469
14Embryonal renal neoplasm (HP:0011794)3.25727230
15Papilledema (HP:0001085)3.24789130
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.23468189
17Nephroblastoma (Wilms tumor) (HP:0002667)3.17684189
18Truncal ataxia (HP:0002078)3.15438767
19Volvulus (HP:0002580)3.11555100
20Colon cancer (HP:0003003)3.09360446
21Oligodactyly (hands) (HP:0001180)3.00273256
22Meckel diverticulum (HP:0002245)2.99931731
23Generalized hypopigmentation of hair (HP:0011358)2.97810796
24Abnormality of the ileum (HP:0001549)2.91927726
25Hemiparesis (HP:0001269)2.79389283
26Action tremor (HP:0002345)2.76383011
27Fair hair (HP:0002286)2.75271388
28Absent speech (HP:0001344)2.73481731
29Medulloblastoma (HP:0002885)2.71656079
30Rhabdomyosarcoma (HP:0002859)2.71159788
31Abnormality of the preputium (HP:0100587)2.70679974
32Abnormality of methionine metabolism (HP:0010901)2.67570090
33Gaze-evoked nystagmus (HP:0000640)2.64423645
34Aqueductal stenosis (HP:0002410)2.63651679
35Drooling (HP:0002307)2.63199658
36Excessive salivation (HP:0003781)2.63199658
37Birth length less than 3rd percentile (HP:0003561)2.60858884
38Abnormality of the labia minora (HP:0012880)2.56751022
39Resting tremor (HP:0002322)2.55768427
40Supernumerary spleens (HP:0009799)2.52751876
41Pancreatic fibrosis (HP:0100732)2.50589713
42Bifid tongue (HP:0010297)2.50574197
43Small intestinal stenosis (HP:0012848)2.49910670
44Duodenal stenosis (HP:0100867)2.49910670
45Broad-based gait (HP:0002136)2.49051750
46Absent frontal sinuses (HP:0002688)2.48092953
47Impaired smooth pursuit (HP:0007772)2.46232402
48Pancreatic cysts (HP:0001737)2.43865432
49Protruding tongue (HP:0010808)2.42542849
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42165269
51Abnormal lung lobation (HP:0002101)2.41922142
52Abnormality of the duodenum (HP:0002246)2.39172906
53Epileptiform EEG discharges (HP:0011182)2.36895845
54True hermaphroditism (HP:0010459)2.34384515
55Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.32593027
56Abnormal biliary tract physiology (HP:0012439)2.32283324
57Bile duct proliferation (HP:0001408)2.32283324
58Blue irides (HP:0000635)2.29959794
59Acanthocytosis (HP:0001927)2.29251059
60Progressive cerebellar ataxia (HP:0002073)2.28937122
61Tubulointerstitial nephritis (HP:0001970)2.28384084
62Depression (HP:0000716)2.27847242
63Status epilepticus (HP:0002133)2.27354761
64Urinary bladder sphincter dysfunction (HP:0002839)2.27026961
65Global brain atrophy (HP:0002283)2.23798389
66Chronic hepatic failure (HP:0100626)2.22903012
67Acute myeloid leukemia (HP:0004808)2.22753558
68Sloping forehead (HP:0000340)2.22307801
69Abnormality of ocular smooth pursuit (HP:0000617)2.21229462
70Methylmalonic acidemia (HP:0002912)2.20135657
71Termporal pattern (HP:0011008)2.19386405
72Insidious onset (HP:0003587)2.19386405
73EEG with generalized epileptiform discharges (HP:0011198)2.19091202
74Upper limb muscle weakness (HP:0003484)2.18519321
75Glioma (HP:0009733)2.17796802
76Abnormality of serum amino acid levels (HP:0003112)2.15814858
77Hypochromic microcytic anemia (HP:0004840)2.15015736
78Absent radius (HP:0003974)2.14917733
79Widely spaced teeth (HP:0000687)2.14160212
80Hypoplastic labia majora (HP:0000059)2.13992432
81Myokymia (HP:0002411)2.13944666
82Poikilocytosis (HP:0004447)2.13136875
83Hemiplegia (HP:0002301)2.12413458
84Impaired vibratory sensation (HP:0002495)2.11931139
85Myelodysplasia (HP:0002863)2.11622042
86Aplasia involving forearm bones (HP:0009822)2.11237233
87Absent forearm bone (HP:0003953)2.11237233
88Labial hypoplasia (HP:0000066)2.11044920
89Thyroid carcinoma (HP:0002890)2.10728053
90Abnormality of salivation (HP:0100755)2.10032876
91Septo-optic dysplasia (HP:0100842)2.09049368
92Abnormality of chromosome segregation (HP:0002916)2.08611891
93Poor eye contact (HP:0000817)2.07628011
94Neoplasm of the colon (HP:0100273)2.07615108
95Hyperventilation (HP:0002883)2.06276724
96Hypsarrhythmia (HP:0002521)2.04912608
97Neoplasm of the adrenal cortex (HP:0100641)2.04766881
98Homocystinuria (HP:0002156)2.04358839
99Abnormality of homocysteine metabolism (HP:0010919)2.04358839
100Clubbing of toes (HP:0100760)2.02887355
101Osteomalacia (HP:0002749)2.02887331
102Ovarian neoplasm (HP:0100615)2.02480212
103Pancreatic islet-cell hyperplasia (HP:0004510)2.02435185
104Ependymoma (HP:0002888)2.01383529
105Aplasia/Hypoplasia of the tongue (HP:0010295)2.01147068
106Abnormality of the astrocytes (HP:0100707)2.00818780
107Astrocytoma (HP:0009592)2.00818780
108Diplopia (HP:0000651)2.00583061
109Abnormality of binocular vision (HP:0011514)2.00583061
110Hypoglycemic seizures (HP:0002173)2.00328255
111Biliary tract neoplasm (HP:0100574)1.99910340
112Obsessive-compulsive behavior (HP:0000722)1.99892442
113Intestinal atresia (HP:0011100)1.98934064
114Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98603040
115Abnormality of alanine metabolism (HP:0010916)1.98603040
116Hyperalaninemia (HP:0003348)1.98603040
117Truncal obesity (HP:0001956)1.97514776
118Impaired social interactions (HP:0000735)1.95694098
119Abnormal social behavior (HP:0012433)1.95694098
120Hydroureter (HP:0000072)1.94591158
121Neoplasm of the small intestine (HP:0100833)1.93914378
122Urethral obstruction (HP:0000796)1.93317955
123Abnormality of the septum pellucidum (HP:0007375)1.92268092
124Abnormality of midbrain morphology (HP:0002418)1.91348768
125Molar tooth sign on MRI (HP:0002419)1.91348768
126Hyperglycinemia (HP:0002154)1.90339952
127Papillary thyroid carcinoma (HP:0002895)1.89127016
128Neoplasm of the adrenal gland (HP:0100631)1.88106590
129Hypoplastic female external genitalia (HP:0012815)1.87771521
130Abnormality of the labia majora (HP:0012881)1.85781666
131Symptomatic seizures (HP:0011145)1.85643693
132Neoplasm of striated muscle (HP:0009728)1.85269527
133Abnormality of the labia (HP:0000058)1.82756168
134Scanning speech (HP:0002168)1.81786856
135Abnormality of abdominal situs (HP:0011620)1.81368568
136Abdominal situs inversus (HP:0003363)1.81368568
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.81325449
138Cortical dysplasia (HP:0002539)1.81044902
139Hyperkalemia (HP:0002153)1.80522730
140Stereotypic behavior (HP:0000733)1.80492805
141Abnormality of vitamin B metabolism (HP:0004340)1.80054194
142Dysmetria (HP:0001310)1.79565593
143Gonadotropin excess (HP:0000837)1.78815080
144Triphalangeal thumb (HP:0001199)1.78601064
145Overlapping toe (HP:0001845)1.78314929
146Gastrointestinal atresia (HP:0002589)1.77274662
147Embryonal neoplasm (HP:0002898)1.77228867
148Relative macrocephaly (HP:0004482)1.77117617
149Facial hemangioma (HP:0000329)1.76550514
150Gastroesophageal reflux (HP:0002020)1.76241241
151Hypoplastic nipples (HP:0002557)1.75254122
152Absent eyebrow (HP:0002223)1.75057100
153Hypocalcemia (HP:0002901)1.74985780
154Genital tract atresia (HP:0001827)1.73891285
155Deeply set eye (HP:0000490)1.72378546
156Cupped ear (HP:0000378)1.72232904
157Abnormality of calcium-phosphate metabolism (HP:0100530)1.71560478
158Dysdiadochokinesis (HP:0002075)1.71356409
159Sensory axonal neuropathy (HP:0003390)1.70844899
160Abnormality of the antihelix (HP:0009738)1.70710438
161Prostate neoplasm (HP:0100787)1.70687237
162Small hand (HP:0200055)1.70320246
163Inappropriate behavior (HP:0000719)1.69935646
164Heterotopia (HP:0002282)1.68783575
165Short middle phalanx of the 5th finger (HP:0004220)1.68528134
166Medial flaring of the eyebrow (HP:0010747)1.68329422
167Hepatoblastoma (HP:0002884)1.67869275
168Ectopic kidney (HP:0000086)1.67842576
169Cafe-au-lait spot (HP:0000957)1.67205202
170Central scotoma (HP:0000603)1.67067979
171Absent septum pellucidum (HP:0001331)1.66875579
172Macroorchidism (HP:0000053)1.66220544
173Decreased lacrimation (HP:0000633)1.65229695
174Facial cleft (HP:0002006)1.65145903
175Arteriovenous malformation (HP:0100026)1.64402563
176Furrowed tongue (HP:0000221)1.63414992
177Insulin-resistant diabetes mellitus (HP:0000831)1.63246201
178Narrow palate (HP:0000189)1.62967185
179Median cleft lip (HP:0000161)1.62197581
180Clitoromegaly (HP:0000057)1.62105089
181Renal cortical cysts (HP:0000803)1.62052689
182Anxiety (HP:0000739)1.61673504
183Preaxial hand polydactyly (HP:0001177)1.61120177
184Hyperinsulinemic hypoglycemia (HP:0000825)1.60881335
185Vaginal atresia (HP:0000148)1.60830759
186Lip pit (HP:0100267)1.58759489
187Abnormality of the nasal septum (HP:0000419)1.58627686
188Confusion (HP:0001289)1.58611798
189Freckling (HP:0001480)1.57518309

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.86937221
2RIPK43.79722005
3EPHA43.55264777
4BUB12.89405283
5MAP3K42.78815986
6MKNK22.78428125
7ACVR1B2.76009561
8TTK2.69688400
9MAP2K72.69459689
10TSSK62.61489851
11BRSK22.56855623
12PBK2.43485680
13NUAK12.42224748
14EIF2AK32.34245713
15MKNK12.33742132
16TRIM282.22022601
17CASK2.10904126
18BMPR1B2.03016382
19AKT31.99296881
20PLK41.98089714
21SRPK11.94910463
22PRKD31.94904982
23MAP2K41.94507322
24SGK21.90350645
25PNCK1.87680849
26CAMK1G1.81130267
27TAF11.64671345
28MAP3K21.64550978
29SGK31.63294618
30BMPR21.58340154
31WEE11.56559336
32EIF2AK11.54769638
33CAMK1D1.54527791
34STK391.52242048
35INSRR1.50303541
36TNIK1.49960748
37PRPF4B1.48719481
38NTRK11.45926816
39MINK11.42269085
40MAP3K91.41911777
41CAMKK21.39164443
42STK31.37735199
43NTRK21.34477986
44PLK21.30567097
45GRK71.28805651
46YES11.28718354
47SGK4941.23398800
48SGK2231.23398800
49TNK21.23204643
50SGK11.21889826
51PLK11.21734780
52VRK11.20774384
53MAP3K131.19749308
54PRKCH1.19578184
55ERBB31.19216281
56ATR1.11721542
57NEK91.09491355
58FGFR21.09165498
59PINK11.09151346
60ZAK1.08158741
61MAPK131.07765191
62CAMKK11.07560709
63FRK1.05337520
64FGFR11.00496568
65MUSK0.99765604
66NEK10.98927325
67CDK50.98411564
68STK240.97970171
69MAP3K120.95995263
70CHEK20.94751823
71FER0.94715052
72STK38L0.93206194
73BRD40.93090592
74STK380.89858055
75FGFR30.87981969
76FES0.87832309
77STK110.86747506
78STK160.85974995
79TGFBR10.85872982
80WNK40.84904357
81KSR10.84233191
82OBSCN0.83312916
83NLK0.82973009
84OXSR10.82904967
85PAK60.82361528
86CDC70.81483530
87RET0.81119336
88SCYL20.80539158
89SIK20.79928465
90MAPK100.76303363
91CDK120.75756422
92PRKCG0.75555195
93CHEK10.75261207
94TXK0.74058020
95MAP4K20.73741201
96PASK0.72961110
97MARK30.72495888
98LATS10.71762183
99BRSK10.71686074
100FLT30.71424648
101CAMK2A0.70675091
102AURKB0.70251176
103JAK10.70020706
104MELK0.69851837
105CSNK1G10.69736506
106TEC0.66732047
107PRKCE0.66108964
108FGR0.64634080
109EIF2AK20.63637558
110DYRK30.63346630
111GRK50.63254356
112WNK10.62617124
113RPS6KA30.62022157
114PRKD20.62009321
115MAP3K100.60626245
116CSNK1D0.60158493
117HIPK20.58151119
118PDK10.57878087
119CAMK2B0.56789450
120CDK30.56433688
121PLK30.55252542
122STK40.53782207
123PRKCQ0.53321506
124RPS6KB10.52774801
125PRKG10.52492423
126MST40.51738436
127CAMK40.51568521
128TRPM70.51354950
129GRK10.50700869
130PRKCB0.49549135
131PDGFRB0.49507959
132PDGFRA0.48070028
133NEK20.47911132
134DAPK20.47893077
135ADRBK20.47661199
136FYN0.46145503
137ATM0.44842781
138CSNK1E0.44009480
139MAPK140.43595211
140VRK20.42942331
141BCR0.42768076
142PDK20.42756336
143NEK60.42290984
144ALK0.41702962
145CDK10.41659373
146CSNK1A1L0.41468924
147GSK3B0.41433086
148UHMK10.40820337
149KSR20.40365094
150BRAF0.39795354
151WNK30.39460889
152PRKDC0.37486855
153AKT10.36993472
154DYRK1A0.36537862
155PTK2B0.36126178
156JAK20.35808926
157PRKAA20.35806712
158MET0.35697623
159CSNK1A10.35334848
160CDC42BPA0.35222172
161RPS6KA40.34360635
162CSNK2A20.34226140
163CDK20.33405572
164CDK90.32081181
165ERBB40.31873985
166PAK30.30635248
167RPS6KA50.29075428
168CSNK1G20.28206510
169RPS6KB20.25436851

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.67363660
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55052090
3Protein export_Homo sapiens_hsa030603.32248531
4Nicotine addiction_Homo sapiens_hsa050333.29539403
5Homologous recombination_Homo sapiens_hsa034402.95459576
6Basal transcription factors_Homo sapiens_hsa030222.92422875
7Mismatch repair_Homo sapiens_hsa034302.87656969
8Long-term potentiation_Homo sapiens_hsa047202.74814402
9Fanconi anemia pathway_Homo sapiens_hsa034602.54623924
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.52503895
11Proteasome_Homo sapiens_hsa030502.52353512
12RNA transport_Homo sapiens_hsa030132.52168627
13RNA degradation_Homo sapiens_hsa030182.45947761
14Morphine addiction_Homo sapiens_hsa050322.45270426
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.44054185
16Cell cycle_Homo sapiens_hsa041102.42985076
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41950453
18Amphetamine addiction_Homo sapiens_hsa050312.38647942
19Propanoate metabolism_Homo sapiens_hsa006402.35837768
20RNA polymerase_Homo sapiens_hsa030202.32845742
21Glutamatergic synapse_Homo sapiens_hsa047242.31539182
22One carbon pool by folate_Homo sapiens_hsa006702.30970799
23Circadian entrainment_Homo sapiens_hsa047132.22581801
24Insulin secretion_Homo sapiens_hsa049112.18851766
25DNA replication_Homo sapiens_hsa030302.10745298
26Olfactory transduction_Homo sapiens_hsa047402.10191735
27GABAergic synapse_Homo sapiens_hsa047272.08863457
28Nucleotide excision repair_Homo sapiens_hsa034201.97715520
29Dopaminergic synapse_Homo sapiens_hsa047281.89307868
30Synaptic vesicle cycle_Homo sapiens_hsa047211.88212844
31Spliceosome_Homo sapiens_hsa030401.84164298
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.83291578
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.77175371
34Salivary secretion_Homo sapiens_hsa049701.73622484
35Taste transduction_Homo sapiens_hsa047421.71821608
36Type II diabetes mellitus_Homo sapiens_hsa049301.64925082
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64619862
38Cholinergic synapse_Homo sapiens_hsa047251.61644155
39Selenocompound metabolism_Homo sapiens_hsa004501.56368803
40Dorso-ventral axis formation_Homo sapiens_hsa043201.51560399
41Renin secretion_Homo sapiens_hsa049241.50745113
42mRNA surveillance pathway_Homo sapiens_hsa030151.50309095
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49202484
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48994466
45Cocaine addiction_Homo sapiens_hsa050301.47445965
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45981951
47Serotonergic synapse_Homo sapiens_hsa047261.44500375
48Long-term depression_Homo sapiens_hsa047301.44171444
49Gastric acid secretion_Homo sapiens_hsa049711.41375126
50Calcium signaling pathway_Homo sapiens_hsa040201.40754618
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38987539
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38937681
53Nitrogen metabolism_Homo sapiens_hsa009101.35270854
54Pyruvate metabolism_Homo sapiens_hsa006201.34267945
55Base excision repair_Homo sapiens_hsa034101.30919686
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.30465995
57GnRH signaling pathway_Homo sapiens_hsa049121.28808523
58Oxytocin signaling pathway_Homo sapiens_hsa049211.28186667
59TGF-beta signaling pathway_Homo sapiens_hsa043501.27868804
60Steroid biosynthesis_Homo sapiens_hsa001001.27332233
61p53 signaling pathway_Homo sapiens_hsa041151.24404039
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23628251
63cAMP signaling pathway_Homo sapiens_hsa040241.23452722
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20698478
65Glioma_Homo sapiens_hsa052141.16958729
66Estrogen signaling pathway_Homo sapiens_hsa049151.16557870
67Alcoholism_Homo sapiens_hsa050341.16161189
68Parkinsons disease_Homo sapiens_hsa050121.15211265
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14935699
70Purine metabolism_Homo sapiens_hsa002301.14613970
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13245183
72Inositol phosphate metabolism_Homo sapiens_hsa005621.12482623
73Type I diabetes mellitus_Homo sapiens_hsa049401.09674671
74Huntingtons disease_Homo sapiens_hsa050161.08009932
75Circadian rhythm_Homo sapiens_hsa047101.07662269
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07151745
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06889098
78Glucagon signaling pathway_Homo sapiens_hsa049221.06349759
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06068495
80Oxidative phosphorylation_Homo sapiens_hsa001901.04785099
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04247289
82Collecting duct acid secretion_Homo sapiens_hsa049661.01435447
83Vascular smooth muscle contraction_Homo sapiens_hsa042701.01147495
84Gap junction_Homo sapiens_hsa045400.99715825
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98453362
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97621924
87Choline metabolism in cancer_Homo sapiens_hsa052310.95043956
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94384813
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92220177
90Pancreatic secretion_Homo sapiens_hsa049720.89803306
91Pyrimidine metabolism_Homo sapiens_hsa002400.89716602
92Melanogenesis_Homo sapiens_hsa049160.89316007
93ABC transporters_Homo sapiens_hsa020100.84707941
94ErbB signaling pathway_Homo sapiens_hsa040120.84361000
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82110147
96Lysine degradation_Homo sapiens_hsa003100.81386633
97Butanoate metabolism_Homo sapiens_hsa006500.80834477
98Thyroid hormone synthesis_Homo sapiens_hsa049180.80738560
99Systemic lupus erythematosus_Homo sapiens_hsa053220.79631798
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79300995
101Folate biosynthesis_Homo sapiens_hsa007900.78077722
102Ribosome_Homo sapiens_hsa030100.77665541
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77525610
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77076418
105MAPK signaling pathway_Homo sapiens_hsa040100.76367547
106Oocyte meiosis_Homo sapiens_hsa041140.76098388
107Phototransduction_Homo sapiens_hsa047440.76088346
108T cell receptor signaling pathway_Homo sapiens_hsa046600.73630516
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.72938283
110Chemokine signaling pathway_Homo sapiens_hsa040620.72077238
111African trypanosomiasis_Homo sapiens_hsa051430.71761586
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71176740
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70837857
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67671562
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67336804
116Alzheimers disease_Homo sapiens_hsa050100.66290274
117Axon guidance_Homo sapiens_hsa043600.65945621
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64859718
119Rap1 signaling pathway_Homo sapiens_hsa040150.64535446
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64280914
121Hippo signaling pathway_Homo sapiens_hsa043900.63925937
122Sulfur metabolism_Homo sapiens_hsa009200.63227842
123mTOR signaling pathway_Homo sapiens_hsa041500.62988215
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61729712
125Peroxisome_Homo sapiens_hsa041460.61717068
126FoxO signaling pathway_Homo sapiens_hsa040680.61477623
127Mineral absorption_Homo sapiens_hsa049780.58721190
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.57791435
129Ras signaling pathway_Homo sapiens_hsa040140.56037107
130Hedgehog signaling pathway_Homo sapiens_hsa043400.55441572
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55139727
132Prostate cancer_Homo sapiens_hsa052150.54500657
133Wnt signaling pathway_Homo sapiens_hsa043100.53599887
134Metabolic pathways_Homo sapiens_hsa011000.53143669
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.53009006
136Vitamin digestion and absorption_Homo sapiens_hsa049770.52569667
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51831130
138Glutathione metabolism_Homo sapiens_hsa004800.51677464
139N-Glycan biosynthesis_Homo sapiens_hsa005100.50742137
140Fatty acid metabolism_Homo sapiens_hsa012120.50524559
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49384606
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48099435
143Prolactin signaling pathway_Homo sapiens_hsa049170.47943225
144Caffeine metabolism_Homo sapiens_hsa002320.47295453
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.46919331
146Basal cell carcinoma_Homo sapiens_hsa052170.46917702
147Carbon metabolism_Homo sapiens_hsa012000.46376054
148Fatty acid elongation_Homo sapiens_hsa000620.46047077
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45351119
150Retinol metabolism_Homo sapiens_hsa008300.45040850
151Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44934644
152MicroRNAs in cancer_Homo sapiens_hsa052060.44781837
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43960254
154Regulation of autophagy_Homo sapiens_hsa041400.43800853
155Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43465747
156Tuberculosis_Homo sapiens_hsa051520.43336018
157Adherens junction_Homo sapiens_hsa045200.43248780
158Melanoma_Homo sapiens_hsa052180.42428228
159Fatty acid degradation_Homo sapiens_hsa000710.40865942
160Non-small cell lung cancer_Homo sapiens_hsa052230.40458823
161Insulin resistance_Homo sapiens_hsa049310.40103418
162Tryptophan metabolism_Homo sapiens_hsa003800.39885633
163Vitamin B6 metabolism_Homo sapiens_hsa007500.39449325
164Insulin signaling pathway_Homo sapiens_hsa049100.39228095
165Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37223378
166Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36774432
167B cell receptor signaling pathway_Homo sapiens_hsa046620.36385320
168Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36323886
169Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35970788
170Endometrial cancer_Homo sapiens_hsa052130.33395530
171Viral carcinogenesis_Homo sapiens_hsa052030.33341531
172beta-Alanine metabolism_Homo sapiens_hsa004100.33171711
173Osteoclast differentiation_Homo sapiens_hsa043800.32952428
1742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32686094
175Platelet activation_Homo sapiens_hsa046110.32146460
176Biosynthesis of amino acids_Homo sapiens_hsa012300.29764023
177Tight junction_Homo sapiens_hsa045300.29125292
178Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27355364
179Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21573057
180Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21015294
181Arginine and proline metabolism_Homo sapiens_hsa003300.18895675
182Cardiac muscle contraction_Homo sapiens_hsa042600.18221526
183Epstein-Barr virus infection_Homo sapiens_hsa051690.18097180

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