USP46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.56597867
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.42200265
3locomotory exploration behavior (GO:0035641)5.18066979
4glutamate secretion (GO:0014047)4.90325908
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.88581009
6synaptic vesicle exocytosis (GO:0016079)4.84621876
7synaptic vesicle maturation (GO:0016188)4.65250370
8regulation of synaptic vesicle exocytosis (GO:2000300)4.61560646
9vocalization behavior (GO:0071625)4.56135234
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.46169508
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.40351826
12regulation of synaptic vesicle transport (GO:1902803)4.33479393
13neuronal action potential propagation (GO:0019227)4.31836756
14layer formation in cerebral cortex (GO:0021819)4.24461793
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.19204393
16protein localization to synapse (GO:0035418)4.11191571
17neuron cell-cell adhesion (GO:0007158)4.09226392
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.07458577
19regulation of glutamate receptor signaling pathway (GO:1900449)4.06376180
20glutamate receptor signaling pathway (GO:0007215)4.05769420
21synaptic transmission, glutamatergic (GO:0035249)3.97309003
22exploration behavior (GO:0035640)3.92018323
23regulation of neuronal synaptic plasticity (GO:0048168)3.88211748
24presynaptic membrane assembly (GO:0097105)3.87450117
25synaptic vesicle endocytosis (GO:0048488)3.83814636
26neuron-neuron synaptic transmission (GO:0007270)3.75120211
27gamma-aminobutyric acid signaling pathway (GO:0007214)3.68693048
28presynaptic membrane organization (GO:0097090)3.66548453
29innervation (GO:0060384)3.63117723
30neurotransmitter secretion (GO:0007269)3.62542167
31G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.58188400
32proline transport (GO:0015824)3.53989347
33cellular potassium ion homeostasis (GO:0030007)3.53022286
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.45698053
35long-term memory (GO:0007616)3.43123126
36positive regulation of action potential (GO:0045760)3.39186228
37regulation of vesicle fusion (GO:0031338)3.37831048
38neurotransmitter-gated ion channel clustering (GO:0072578)3.36856867
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36373386
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.34161092
41neuron recognition (GO:0008038)3.31389757
42regulation of synapse structural plasticity (GO:0051823)3.30325028
43regulation of dendritic spine morphogenesis (GO:0061001)3.29358403
44regulation of postsynaptic membrane potential (GO:0060078)3.28988367
45dendritic spine morphogenesis (GO:0060997)3.27576555
46regulation of synaptic plasticity (GO:0048167)3.24424109
47positive regulation of membrane potential (GO:0045838)3.22396367
48regulation of calcium ion-dependent exocytosis (GO:0017158)3.21354363
49cerebellar Purkinje cell differentiation (GO:0021702)3.20555180
50activation of protein kinase A activity (GO:0034199)3.20328143
51long-term synaptic potentiation (GO:0060291)3.19514213
52positive regulation of synapse maturation (GO:0090129)3.19295563
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18540297
54negative regulation of hormone metabolic process (GO:0032351)3.17918492
55negative regulation of hormone biosynthetic process (GO:0032353)3.17918492
56negative regulation of synaptic transmission, GABAergic (GO:0032229)3.11119136
57positive regulation of vesicle fusion (GO:0031340)3.10335578
58positive regulation of neurotransmitter secretion (GO:0001956)3.09821705
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.09746177
60gamma-aminobutyric acid transport (GO:0015812)3.09546664
61axonal fasciculation (GO:0007413)3.08850695
62sodium ion export (GO:0071436)3.07691181
63detection of calcium ion (GO:0005513)3.06574235
64neurotransmitter transport (GO:0006836)3.04881448
65regulation of neurotransmitter secretion (GO:0046928)3.04299869
66postsynaptic membrane organization (GO:0001941)2.97978016
67cell communication by electrical coupling (GO:0010644)2.96254237
68regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96049171
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.94840923
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94401774
71positive regulation of neurotransmitter transport (GO:0051590)2.92475664
72regulation of cAMP-dependent protein kinase activity (GO:2000479)2.91839802
73regulation of neurotransmitter transport (GO:0051588)2.90926324
74dendritic spine organization (GO:0097061)2.89498015
75* behavioral defense response (GO:0002209)2.88554675
76* behavioral fear response (GO:0001662)2.88554675
77neuromuscular process controlling balance (GO:0050885)2.88322694
78positive regulation of dendritic spine morphogenesis (GO:0061003)2.87906682
79* fear response (GO:0042596)2.85397465
80transmission of nerve impulse (GO:0019226)2.84257413
81vesicle transport along microtubule (GO:0047496)2.84153411
82L-amino acid import (GO:0043092)2.83118561
83membrane depolarization (GO:0051899)2.81465693
84membrane depolarization during action potential (GO:0086010)2.80313574
85regulation of neurotransmitter levels (GO:0001505)2.78539789
86glycine transport (GO:0015816)2.76868374
87regulation of clathrin-mediated endocytosis (GO:2000369)2.76841423
88auditory behavior (GO:0031223)2.75387618
89regulation of gene silencing by RNA (GO:0060966)2.75035817
90regulation of posttranscriptional gene silencing (GO:0060147)2.75035817
91regulation of gene silencing by miRNA (GO:0060964)2.75035817
92axon ensheathment in central nervous system (GO:0032291)2.73858339
93central nervous system myelination (GO:0022010)2.73858339
94dendrite morphogenesis (GO:0048813)2.73226827
95long term synaptic depression (GO:0060292)2.72555601
96chemosensory behavior (GO:0007635)2.72470344
97response to auditory stimulus (GO:0010996)2.72460640
98learning (GO:0007612)2.72306361
99negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72210785
100paraxial mesoderm development (GO:0048339)2.71873211
101regulation of cell communication by electrical coupling (GO:0010649)2.71816545
102* regulation of synaptic transmission (GO:0050804)2.69450643
103establishment of synaptic vesicle localization (GO:0097480)2.67546766
104synaptic vesicle transport (GO:0048489)2.67546766
105cochlea development (GO:0090102)2.67456792
106positive regulation of synaptic transmission (GO:0050806)2.67349470
107establishment of nucleus localization (GO:0040023)2.67057020
108regulation of dendritic spine development (GO:0060998)2.66879480
109social behavior (GO:0035176)2.66180412
110intraspecies interaction between organisms (GO:0051703)2.66180412
111synaptic transmission (GO:0007268)2.65680883
112synapse assembly (GO:0007416)2.65508799
113amino acid import (GO:0043090)2.64130020
114cell communication involved in cardiac conduction (GO:0086065)2.63444192
115C4-dicarboxylate transport (GO:0015740)2.62267530
116cerebellar granule cell differentiation (GO:0021707)2.55806757
117neurotransmitter uptake (GO:0001504)2.53238619
118urinary tract smooth muscle contraction (GO:0014848)2.53146106
119tachykinin receptor signaling pathway (GO:0007217)2.46512526
120potassium ion import (GO:0010107)2.40295280
121regulation of voltage-gated calcium channel activity (GO:1901385)2.40100859
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.39189325
123neuromuscular synaptic transmission (GO:0007274)2.39029481
124regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.31633480
125regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.29920528
126adult walking behavior (GO:0007628)2.29592602
127positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.28688394
128retinal cone cell development (GO:0046549)2.27048410
129limb bud formation (GO:0060174)2.26943945
130serotonin metabolic process (GO:0042428)2.26605043
131mechanosensory behavior (GO:0007638)2.23490834
132regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.23421043
133cellular sodium ion homeostasis (GO:0006883)2.22838866
134neuronal action potential (GO:0019228)2.22015439
135positive regulation of synaptic transmission, GABAergic (GO:0032230)2.20332574
136potassium ion homeostasis (GO:0055075)2.20239959
137* regulation of synaptic transmission, GABAergic (GO:0032228)2.18606413
138central nervous system projection neuron axonogenesis (GO:0021952)2.18012773
139notochord development (GO:0030903)2.17539479
140neuronal ion channel clustering (GO:0045161)2.17506446
141acidic amino acid transport (GO:0015800)2.17375046
142positive regulation of dendritic spine development (GO:0060999)2.16759552
143regulation of action potential (GO:0098900)2.16347357
144startle response (GO:0001964)2.15641713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.96519329
2GBX2_23144817_ChIP-Seq_PC3_Human3.49734910
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83621469
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70219312
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65237030
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.52591788
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51733203
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51733203
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32175791
10REST_21632747_ChIP-Seq_MESCs_Mouse2.25635116
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23954383
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22972216
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.22798004
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19380373
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.14597645
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14483030
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14334871
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.04357266
19RARB_27405468_Chip-Seq_BRAIN_Mouse1.99683110
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98505814
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.93231901
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91638297
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89835353
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88739391
25AR_21572438_ChIP-Seq_LNCaP_Human1.86806182
26SMAD4_21799915_ChIP-Seq_A2780_Human1.85891312
27DROSHA_22980978_ChIP-Seq_HELA_Human1.85450269
28TAF15_26573619_Chip-Seq_HEK293_Human1.81754387
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80934091
30* REST_18959480_ChIP-ChIP_MESCs_Mouse1.76192903
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71211937
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.69995979
33IGF1R_20145208_ChIP-Seq_DFB_Human1.68361195
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60050483
35EWS_26573619_Chip-Seq_HEK293_Human1.57370623
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56227559
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54578532
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54241615
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54219510
40P300_19829295_ChIP-Seq_ESCs_Human1.51485960
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.50892967
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48599128
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48238474
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47624198
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47249447
46* STAT3_23295773_ChIP-Seq_U87_Human1.46498311
47* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44180922
48RNF2_27304074_Chip-Seq_NSC_Mouse1.40979312
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40497359
50FUS_26573619_Chip-Seq_HEK293_Human1.39392967
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.39317838
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39180260
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38565418
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37533729
55ZNF274_21170338_ChIP-Seq_K562_Hela1.37169286
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.36199106
57* AR_25329375_ChIP-Seq_VCAP_Human1.36048307
58MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32771555
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32467519
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32379706
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32245154
62SOX9_26525672_Chip-Seq_HEART_Mouse1.30935253
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30777274
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30122288
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.29865568
66* SMAD3_21741376_ChIP-Seq_EPCs_Human1.29008896
67* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26264549
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25935072
69TCF4_23295773_ChIP-Seq_U87_Human1.25333928
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25033651
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23752869
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23732774
73AR_19668381_ChIP-Seq_PC3_Human1.22778496
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22639542
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21668038
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21315411
77* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20358090
78EP300_21415370_ChIP-Seq_HL-1_Mouse1.19557267
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18413053
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17964771
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17650385
82CBP_20019798_ChIP-Seq_JUKART_Human1.17650385
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17136831
84TBX3_20139965_ChIP-Seq_MESCs_Mouse1.16447279
85* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15955168
86TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15915899
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14629732
88* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14407864
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.14127241
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13770775
91VDR_22108803_ChIP-Seq_LS180_Human1.12717723
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12395255
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12394937
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.11944176
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.11490752
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11091227
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10803933
98TP53_16413492_ChIP-PET_HCT116_Human1.10270971
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09448573
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09046177
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08818310
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08779812
103CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08517811
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07837110
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07699741
106RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07380481
107BCAT_22108803_ChIP-Seq_LS180_Human1.06549351
108* RUNX2_22187159_ChIP-Seq_PCA_Human1.05838551
109* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05500010
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04324274
111SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03975827
112RING1B_27294783_Chip-Seq_NPCs_Mouse1.03358253
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.03244999
114P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02704591
115ESR1_20079471_ChIP-ChIP_T-47D_Human1.02453050
116POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01140691
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.00991612
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00777614
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00777614
120* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00755954
121TCF4_22108803_ChIP-Seq_LS180_Human0.99969765
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99914617
123ERG_21242973_ChIP-ChIP_JURKAT_Human0.99573047
124* SMAD3_21741376_ChIP-Seq_ESCs_Human0.99304363
125AHR_22903824_ChIP-Seq_MCF-7_Human0.99063291
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.98963666
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93505866

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.09653755
2MP0003880_abnormal_central_pattern4.25844738
3MP0003635_abnormal_synaptic_transmissio3.80689625
4MP0004270_analgesia3.58405504
5MP0002063_abnormal_learning/memory/cond3.06737018
6MP0001968_abnormal_touch/_nociception2.95201897
7MP0009745_abnormal_behavioral_response2.89644548
8MP0009046_muscle_twitch2.68450889
9MP0002734_abnormal_mechanical_nocicepti2.63041020
10MP0002064_seizures2.56089458
11MP0002572_abnormal_emotion/affect_behav2.52848383
12MP0002736_abnormal_nociception_after2.36564996
13MP0001486_abnormal_startle_reflex2.35881480
14MP0002272_abnormal_nervous_system2.32707371
15MP0002735_abnormal_chemical_nociception1.93669333
16MP0002067_abnormal_sensory_capabilities1.93507252
17MP0001440_abnormal_grooming_behavior1.92804756
18MP0002733_abnormal_thermal_nociception1.89140877
19MP0001501_abnormal_sleep_pattern1.88057091
20MP0002184_abnormal_innervation1.84119553
21MP0005423_abnormal_somatic_nervous1.83945360
22MP0001970_abnormal_pain_threshold1.83559962
23MP0004145_abnormal_muscle_electrophysio1.82813342
24MP0003136_yellow_coat_color1.80566977
25MP0005646_abnormal_pituitary_gland1.78955345
26MP0003787_abnormal_imprinting1.78304779
27MP0009780_abnormal_chondrocyte_physiolo1.77115550
28MP0003890_abnormal_embryonic-extraembry1.69562833
29MP0000778_abnormal_nervous_system1.69240573
30MP0003879_abnormal_hair_cell1.66484504
31MP0005386_behavior/neurological_phenoty1.64108656
32MP0004924_abnormal_behavior1.64108656
33MP0002557_abnormal_social/conspecific_i1.62016924
34MP0003941_abnormal_skin_development1.61600489
35MP0008569_lethality_at_weaning1.58770011
36MP0004811_abnormal_neuron_physiology1.49682503
37MP0002102_abnormal_ear_morphology1.46133318
38MP0001188_hyperpigmentation1.44170255
39MP0006276_abnormal_autonomic_nervous1.44030729
40MP0000955_abnormal_spinal_cord1.42772244
41MP0002938_white_spotting1.40215861
42MP0001905_abnormal_dopamine_level1.38385920
43MP0003329_amyloid_beta_deposits1.38011626
44MP0003646_muscle_fatigue1.36652424
45MP0001984_abnormal_olfaction1.36394863
46MP0010386_abnormal_urinary_bladder1.35465068
47MP0005187_abnormal_penis_morphology1.35200563
48MP0003937_abnormal_limbs/digits/tail_de1.32884272
49MP0002909_abnormal_adrenal_gland1.32250400
50MP0002882_abnormal_neuron_morphology1.30699143
51MP0003119_abnormal_digestive_system1.27689611
52MP0002066_abnormal_motor_capabilities/c1.26906575
53MP0002822_catalepsy1.26129780
54MP0004858_abnormal_nervous_system1.25702400
55MP0004885_abnormal_endolymph1.21843108
56MP0000566_synostosis1.21597947
57MP0002837_dystrophic_cardiac_calcinosis1.20382091
58MP0004215_abnormal_myocardial_fiber1.17728823
59MP0003122_maternal_imprinting1.16958509
60MP0001293_anophthalmia1.15362054
61MP0000579_abnormal_nail_morphology1.13784114
62MP0002152_abnormal_brain_morphology1.12112711
63MP0001529_abnormal_vocalization1.11262070
64MP0002234_abnormal_pharynx_morphology1.11151885
65MP0003283_abnormal_digestive_organ1.10733005
66MP0000631_abnormal_neuroendocrine_gland1.09858865
67MP0002233_abnormal_nose_morphology1.06887264
68MP0001502_abnormal_circadian_rhythm1.06330098
69MP0004484_altered_response_of1.03163534
70MP0008877_abnormal_DNA_methylation1.02935910
71MP0000013_abnormal_adipose_tissue1.01752385
72MP0010234_abnormal_vibrissa_follicle1.00075259
73MP0008057_abnormal_DNA_replication0.99769483
74MP0002751_abnormal_autonomic_nervous0.99662291
75MP0003121_genomic_imprinting0.98965234
76MP0000751_myopathy0.98758985
77MP0010030_abnormal_orbit_morphology0.98754865
78MP0003633_abnormal_nervous_system0.98692492
79MP0003631_nervous_system_phenotype0.98112046
80MP0004133_heterotaxia0.96065774
81MP0009672_abnormal_birth_weight0.95901391
82MP0001963_abnormal_hearing_physiology0.94066335
83MP0004085_abnormal_heartbeat0.93994147
84MP0005645_abnormal_hypothalamus_physiol0.93340672
85MP0006072_abnormal_retinal_apoptosis0.90749787
86MP0003123_paternal_imprinting0.87829886
87MP0003632_abnormal_nervous_system0.87474883
88MP0000749_muscle_degeneration0.87148186
89MP0005253_abnormal_eye_physiology0.86873349
90MP0003385_abnormal_body_wall0.86764634
91MP0002697_abnormal_eye_size0.86405874
92MP0001177_atelectasis0.85968050
93MP0000049_abnormal_middle_ear0.85798979
94MP0001485_abnormal_pinna_reflex0.85473042
95MP0000428_abnormal_craniofacial_morphol0.85182420
96MP0004084_abnormal_cardiac_muscle0.85015261
97MP0005623_abnormal_meninges_morphology0.82895570
98MP0004142_abnormal_muscle_tone0.81864611
99MP0003755_abnormal_palate_morphology0.81626250
100MP0004742_abnormal_vestibular_system0.81596884
101MP0001346_abnormal_lacrimal_gland0.81339310
102MP0005171_absent_coat_pigmentation0.80993072
103MP0002752_abnormal_somatic_nervous0.80435893
104MP0003861_abnormal_nervous_system0.78014193
105MP0003567_abnormal_fetal_cardiomyocyte0.77293090
106MP0005248_abnormal_Harderian_gland0.76682154
107MP0008872_abnormal_physiological_respon0.76585871
108MP0002229_neurodegeneration0.76448699
109MP0005499_abnormal_olfactory_system0.74922419
110MP0005394_taste/olfaction_phenotype0.74922419
111MP0004147_increased_porphyrin_level0.74802153
112MP0000569_abnormal_digit_pigmentation0.73901235
113MP0010094_abnormal_chromosome_stability0.72683323
114MP0002653_abnormal_ependyma_morphology0.71917113
115MP0000537_abnormal_urethra_morphology0.71359055
116MP0001664_abnormal_digestion0.71046776
117MP0003137_abnormal_impulse_conducting0.70557803
118MP0002069_abnormal_eating/drinking_beha0.70472484
119MP0005551_abnormal_eye_electrophysiolog0.70329675
120MP0003718_maternal_effect0.68945907
121MP0004043_abnormal_pH_regulation0.67364235
122MP0000534_abnormal_ureter_morphology0.66234030
123MP0000026_abnormal_inner_ear0.65143568
124MP0004233_abnormal_muscle_weight0.64058506
125MP0006292_abnormal_olfactory_placode0.62325518
126MP0008874_decreased_physiological_sensi0.60471818
127MP0001299_abnormal_eye_distance/0.59535539
128MP0003315_abnormal_perineum_morphology0.57499296
129MP0002876_abnormal_thyroid_physiology0.55683219
130MP0005620_abnormal_muscle_contractility0.55681556
131MP0002249_abnormal_larynx_morphology0.54666033

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.42913866
2Myokymia (HP:0002411)5.72869133
3Focal seizures (HP:0007359)4.77277192
4Atonic seizures (HP:0010819)4.51395250
5Visual hallucinations (HP:0002367)4.46062257
6Progressive cerebellar ataxia (HP:0002073)4.43758291
7Febrile seizures (HP:0002373)4.10805971
8Epileptic encephalopathy (HP:0200134)4.09881288
9Action tremor (HP:0002345)4.05479054
10Absence seizures (HP:0002121)3.59486706
11Generalized tonic-clonic seizures (HP:0002069)3.48405747
12Broad-based gait (HP:0002136)3.29322074
13Gaze-evoked nystagmus (HP:0000640)3.29291010
14Impaired vibration sensation in the lower limbs (HP:0002166)3.06867570
15Dialeptic seizures (HP:0011146)3.06469850
16Genetic anticipation (HP:0003743)3.03327557
17Papilledema (HP:0001085)2.87483092
18Urinary bladder sphincter dysfunction (HP:0002839)2.82745414
19Depression (HP:0000716)2.82430198
20Dysdiadochokinesis (HP:0002075)2.78510398
21Dysmetria (HP:0001310)2.75730515
22Poor eye contact (HP:0000817)2.71950956
23Anxiety (HP:0000739)2.68841151
24Scanning speech (HP:0002168)2.67174465
25Impaired smooth pursuit (HP:0007772)2.60497344
26Abnormal eating behavior (HP:0100738)2.54702366
27Insidious onset (HP:0003587)2.53958573
28Termporal pattern (HP:0011008)2.53958573
29Dysmetric saccades (HP:0000641)2.53126784
30Hyperventilation (HP:0002883)2.52330889
31Amblyopia (HP:0000646)2.49787337
32Truncal ataxia (HP:0002078)2.46981232
33Papillary thyroid carcinoma (HP:0002895)2.44460410
34Absent speech (HP:0001344)2.37985448
35Ankle clonus (HP:0011448)2.36859312
36Drooling (HP:0002307)2.36346123
37Excessive salivation (HP:0003781)2.36346123
38Epileptiform EEG discharges (HP:0011182)2.30854747
39Fetal akinesia sequence (HP:0001989)2.26377731
40Impaired vibratory sensation (HP:0002495)2.25569067
41Agitation (HP:0000713)2.24112932
42Abnormality of ocular smooth pursuit (HP:0000617)2.23664152
43Urinary urgency (HP:0000012)2.17237928
44EEG with generalized epileptiform discharges (HP:0011198)2.16094610
45Mutism (HP:0002300)2.15421538
46Abnormal social behavior (HP:0012433)2.15070103
47Impaired social interactions (HP:0000735)2.15070103
48Cutaneous finger syndactyly (HP:0010554)2.14988851
49Aplasia involving bones of the extremities (HP:0009825)2.10805883
50Aplasia involving bones of the upper limbs (HP:0009823)2.10805883
51Aplasia of the phalanges of the hand (HP:0009802)2.10805883
52Hemiparesis (HP:0001269)2.09414283
53Megalencephaly (HP:0001355)2.08958960
54Postural instability (HP:0002172)2.03706414
55Torticollis (HP:0000473)2.02283333
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.01103045
57Intestinal atresia (HP:0011100)1.97650945
58Hypsarrhythmia (HP:0002521)1.97492904
59Supranuclear gaze palsy (HP:0000605)1.97398879
60Cutaneous syndactyly (HP:0012725)1.95684776
61Ventricular fibrillation (HP:0001663)1.95625915
62Spastic gait (HP:0002064)1.95439783
63Optic nerve hypoplasia (HP:0000609)1.94589779
64Focal dystonia (HP:0004373)1.92064061
65Stereotypic behavior (HP:0000733)1.91907086
66Hepatoblastoma (HP:0002884)1.89196335
67Pheochromocytoma (HP:0002666)1.88400913
68Male infertility (HP:0003251)1.88092029
69Preaxial foot polydactyly (HP:0001841)1.87560054
70Annular pancreas (HP:0001734)1.87154588
71Incomplete penetrance (HP:0003829)1.86592455
72Septo-optic dysplasia (HP:0100842)1.86354113
73Intention tremor (HP:0002080)1.85562601
74Blue irides (HP:0000635)1.85113104
75Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85056036
76Progressive inability to walk (HP:0002505)1.83939282
77Abnormality of binocular vision (HP:0011514)1.83035754
78Diplopia (HP:0000651)1.83035754
79Cerebral inclusion bodies (HP:0100314)1.82536907
80Pointed chin (HP:0000307)1.81826209
81Gait imbalance (HP:0002141)1.81238288
82Gait ataxia (HP:0002066)1.80131854
83Vaginal atresia (HP:0000148)1.77877696
84Bradykinesia (HP:0002067)1.77211099
85Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76765511
86Genital tract atresia (HP:0001827)1.76384209
87Obstructive sleep apnea (HP:0002870)1.74816782
88Bundle branch block (HP:0011710)1.74467513
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72695810
90Status epilepticus (HP:0002133)1.72669085
91Generalized myoclonic seizures (HP:0002123)1.72266573
92Split foot (HP:0001839)1.71246146
93Aplasia/Hypoplasia of the sternum (HP:0006714)1.71212305
94Delusions (HP:0000746)1.71209232
95Thyroid carcinoma (HP:0002890)1.70964203
96Hypoventilation (HP:0002791)1.70425336
97Bifid tongue (HP:0010297)1.68903375
98Inappropriate behavior (HP:0000719)1.67621051
99Abnormality of the labia minora (HP:0012880)1.66990661
100Abnormal lung lobation (HP:0002101)1.66287423
101Chronic bronchitis (HP:0004469)1.65885593
102Colon cancer (HP:0003003)1.65827692
103Anophthalmia (HP:0000528)1.65314425
104Abnormality of the corticospinal tract (HP:0002492)1.65266729
105Inability to walk (HP:0002540)1.65059109
106Syncope (HP:0001279)1.64504083
107Hemiplegia (HP:0002301)1.64119193
108Limb dystonia (HP:0002451)1.64050785
109Abnormality of salivation (HP:0100755)1.63767409
110Lower limb muscle weakness (HP:0007340)1.62773028
111Infertility (HP:0000789)1.62608825
112Cortical dysplasia (HP:0002539)1.62230563
113Nonprogressive disorder (HP:0003680)1.62201231
114Craniofacial dystonia (HP:0012179)1.61990427
115Abnormality of the lower motor neuron (HP:0002366)1.61583633
116Polyphagia (HP:0002591)1.60820803
117Neuroendocrine neoplasm (HP:0100634)1.60736791
118Facial cleft (HP:0002006)1.60242871
119Protruding tongue (HP:0010808)1.59342902
120Spinal canal stenosis (HP:0003416)1.58275659
121Intellectual disability, profound (HP:0002187)1.55768510
122Absent eyebrow (HP:0002223)1.53558725
123Choanal stenosis (HP:0000452)1.52480773
124Aqueductal stenosis (HP:0002410)1.50719889
125Oligodactyly (hands) (HP:0001180)1.50518431
126Gastrointestinal atresia (HP:0002589)1.49052268
127Renal hypoplasia (HP:0000089)1.48893053
128Specific learning disability (HP:0001328)1.47734805
129Absent radius (HP:0003974)1.47660957
130Medial flaring of the eyebrow (HP:0010747)1.47586458
131Pancreatic cysts (HP:0001737)1.46236793
132Esophageal atresia (HP:0002032)1.44223307
133Pancreatic fibrosis (HP:0100732)1.44179858
134Absent forearm bone (HP:0003953)1.44025531
135Aplasia involving forearm bones (HP:0009822)1.44025531
136Astrocytoma (HP:0009592)1.42566267
137Abnormality of the astrocytes (HP:0100707)1.42566267
138Birth length less than 3rd percentile (HP:0003561)1.42379203
139Bilateral microphthalmos (HP:0007633)1.40889555
140Glioma (HP:0009733)1.40566430
141Central scotoma (HP:0000603)1.39842999
142Cerebral hypomyelination (HP:0006808)1.39701698
143Tracheomalacia (HP:0002779)1.39258410
144Abnormality of the antihelix (HP:0009738)1.39049342
145Congenital primary aphakia (HP:0007707)1.38879916
146Nephronophthisis (HP:0000090)1.38742030
147Myelomeningocele (HP:0002475)1.38733943
148Omphalocele (HP:0001539)1.38148467
149Absent septum pellucidum (HP:0001331)1.37916621
150Supernumerary spleens (HP:0009799)1.37797432
151Abnormality of the ischium (HP:0003174)1.37699612

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.95475742
2NTRK33.82637323
3EPHA43.36533864
4KSR23.27132061
5MAP3K43.19408768
6MAP2K72.85999978
7PAK62.34859596
8MINK12.27295305
9LATS22.18270645
10PRKD32.17953448
11KSR12.12827849
12MAP2K42.10908078
13MAP3K122.08067381
14MKNK22.00359998
15MARK11.98951164
16MAP3K61.97559410
17BMPR1B1.79927581
18CASK1.73941140
19MUSK1.71321093
20DAPK21.68463020
21ARAF1.66200139
22PLK21.66031300
23RAF11.61697703
24STK381.57657345
25WNK31.56672937
26NTRK21.55366526
27FRK1.53748088
28NTRK11.51748858
29MAP3K21.50017143
30MAP3K131.49592906
31MKNK11.49046457
32TSSK61.47818983
33MAPK131.46343598
34CAMKK11.43961543
35CDC71.38206774
36BRAF1.36593509
37OBSCN1.34565383
38TTK1.33307426
39LATS11.31841156
40TRIM281.30191886
41TNIK1.28496817
42CDK191.28217940
43GRK51.28215773
44PBK1.25535773
45ERBB31.24231918
46ZAK1.15849395
47PNCK1.15107176
48BCR1.15007330
49FGFR21.12751511
50RET1.11431140
51RIPK41.10974910
52WEE11.10106159
53CDK51.09924443
54CAMKK21.09775907
55PLK31.07865577
56TAOK11.01821405
57BMPR21.01161723
58DAPK10.99505536
59CAMK2A0.98297104
60PINK10.95237820
61TYRO30.90374752
62BRSK20.90025484
63PRPF4B0.86709163
64ACVR1B0.86700832
65DYRK20.84532509
66PTK2B0.83938301
67PRKCG0.83412418
68SRPK10.82813118
69MAP3K10.81918692
70MOS0.79860388
71CAMK10.78919355
72FER0.78342928
73SGK2230.78195468
74SGK4940.78195468
75SGK20.76563110
76PLK40.75526485
77OXSR10.75455790
78MAPKAPK50.75149745
79PAK30.74349570
80CSNK1G20.73704342
81DMPK0.72825599
82CDK180.72480406
83CSNK1G10.72264736
84CDK150.70907520
85CDK140.70796444
86ERBB40.70469048
87STK390.69199047
88STK110.68095293
89FGFR10.67792539
90ALK0.67496716
91BRD40.67485397
92AKT30.67383577
93PLK10.64506405
94MAP2K10.63844663
95FES0.62772140
96CSNK1A1L0.62762391
97CAMK2B0.61911798
98DYRK1A0.61869697
99WNK10.61509075
100MARK20.59551400
101PKN10.58933112
102CDK11A0.57979778
103SGK10.57429222
104STK30.56485122
105CAMK2G0.55755612
106TAF10.54962615
107RIPK10.53617399
108EIF2AK30.53574035
109PDK10.52945181
110CSNK1E0.52344651
111UHMK10.51693693
112PDPK10.49581502
113CSNK1D0.48243683
114TGFBR10.47894204
115CSNK1G30.47313230
116NEK60.47215132
117PRKCH0.46712893
118SGK30.45365718
119MAP4K20.45253945
120ROCK20.44411747
121PRKDC0.44136469
122CAMK40.43949506
123EIF2AK20.43486777
124PRKCE0.42662434
125PDK30.41731675
126PDK40.41731675
127CAMK2D0.41085054
128RPS6KA20.41010374
129NEK10.39723591
130STK38L0.39517853
131CAMK1G0.39287822
132PHKG20.39286816
133PHKG10.39286816
134RPS6KA30.39202209
135PRKD20.39034425
136SCYL20.37816812
137BRSK10.37698494
138ADRBK10.37480858
139CDK80.35339657
140FGR0.35071931
141MAPK100.34102393
142MAP3K50.31504853
143SIK20.31430523
144LMTK20.31312709

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.55751733
2Synaptic vesicle cycle_Homo sapiens_hsa047212.77568854
3Long-term potentiation_Homo sapiens_hsa047202.75362445
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57156880
5Glutamatergic synapse_Homo sapiens_hsa047242.54864597
6Circadian entrainment_Homo sapiens_hsa047132.53910036
7Olfactory transduction_Homo sapiens_hsa047402.46355357
8GABAergic synapse_Homo sapiens_hsa047272.33718543
9Amphetamine addiction_Homo sapiens_hsa050312.31045455
10Morphine addiction_Homo sapiens_hsa050322.25888545
11Salivary secretion_Homo sapiens_hsa049702.07170627
12Dopaminergic synapse_Homo sapiens_hsa047282.06037526
13Long-term depression_Homo sapiens_hsa047301.95382594
14Taste transduction_Homo sapiens_hsa047421.94821852
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89352437
16Insulin secretion_Homo sapiens_hsa049111.87962306
17Gastric acid secretion_Homo sapiens_hsa049711.74573066
18Cholinergic synapse_Homo sapiens_hsa047251.72673631
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72478443
20GnRH signaling pathway_Homo sapiens_hsa049121.69822156
21Serotonergic synapse_Homo sapiens_hsa047261.68631649
22Oxytocin signaling pathway_Homo sapiens_hsa049211.63379853
23Renin secretion_Homo sapiens_hsa049241.62950403
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57617275
25Cocaine addiction_Homo sapiens_hsa050301.44895511
26Calcium signaling pathway_Homo sapiens_hsa040201.44105903
27Gap junction_Homo sapiens_hsa045401.42919919
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42746639
29Oocyte meiosis_Homo sapiens_hsa041141.41145404
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39216041
31cAMP signaling pathway_Homo sapiens_hsa040241.32955638
32Dorso-ventral axis formation_Homo sapiens_hsa043201.31547903
33Estrogen signaling pathway_Homo sapiens_hsa049151.31474840
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27683380
35Glioma_Homo sapiens_hsa052141.26886318
36Collecting duct acid secretion_Homo sapiens_hsa049661.21707108
37Basal transcription factors_Homo sapiens_hsa030221.19078995
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18753617
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15734283
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14344780
41Melanogenesis_Homo sapiens_hsa049161.14068442
42Basal cell carcinoma_Homo sapiens_hsa052171.12146507
43Ovarian steroidogenesis_Homo sapiens_hsa049131.11770255
44ErbB signaling pathway_Homo sapiens_hsa040121.10647830
45Type II diabetes mellitus_Homo sapiens_hsa049301.10626466
46Vitamin B6 metabolism_Homo sapiens_hsa007501.10060767
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09905669
48Circadian rhythm_Homo sapiens_hsa047101.07101227
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.04224185
50Axon guidance_Homo sapiens_hsa043601.04093040
51Selenocompound metabolism_Homo sapiens_hsa004501.03000436
52Non-homologous end-joining_Homo sapiens_hsa034501.00699492
53Propanoate metabolism_Homo sapiens_hsa006401.00045376
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97451306
55Choline metabolism in cancer_Homo sapiens_hsa052310.95249818
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94607057
57Pancreatic secretion_Homo sapiens_hsa049720.92992227
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.91047137
59VEGF signaling pathway_Homo sapiens_hsa043700.86617859
60Butanoate metabolism_Homo sapiens_hsa006500.86198701
61Vibrio cholerae infection_Homo sapiens_hsa051100.86183280
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85273426
63Steroid biosynthesis_Homo sapiens_hsa001000.83546473
64Dilated cardiomyopathy_Homo sapiens_hsa054140.82402129
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81000883
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80825934
67Cardiac muscle contraction_Homo sapiens_hsa042600.80210174
68Thyroid hormone synthesis_Homo sapiens_hsa049180.78671068
69Endometrial cancer_Homo sapiens_hsa052130.77790932
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77770769
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77523630
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.75911878
73Ras signaling pathway_Homo sapiens_hsa040140.75766218
74RNA transport_Homo sapiens_hsa030130.73809108
75Cell cycle_Homo sapiens_hsa041100.73532084
76mRNA surveillance pathway_Homo sapiens_hsa030150.73309279
77mTOR signaling pathway_Homo sapiens_hsa041500.73171266
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73073800
79TGF-beta signaling pathway_Homo sapiens_hsa043500.72956006
80MAPK signaling pathway_Homo sapiens_hsa040100.72838293
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72132317
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71545610
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70805339
84Nitrogen metabolism_Homo sapiens_hsa009100.70552122
85Adherens junction_Homo sapiens_hsa045200.69986034
86Arginine and proline metabolism_Homo sapiens_hsa003300.69936955
87Wnt signaling pathway_Homo sapiens_hsa043100.68856590
88Phototransduction_Homo sapiens_hsa047440.67996076
89Renal cell carcinoma_Homo sapiens_hsa052110.67972166
90Protein export_Homo sapiens_hsa030600.67894768
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67179539
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66515764
93Colorectal cancer_Homo sapiens_hsa052100.64782224
94Inositol phosphate metabolism_Homo sapiens_hsa005620.64639699
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64550555
96Rap1 signaling pathway_Homo sapiens_hsa040150.64335940
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63873995
98Glucagon signaling pathway_Homo sapiens_hsa049220.63204134
99Fanconi anemia pathway_Homo sapiens_hsa034600.61385262
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61285348
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61250917
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61098347
103beta-Alanine metabolism_Homo sapiens_hsa004100.60909517
104Mismatch repair_Homo sapiens_hsa034300.60662242
105Non-small cell lung cancer_Homo sapiens_hsa052230.60483659
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.58793230
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58078547
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57619495
109Alcoholism_Homo sapiens_hsa050340.57042543
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.56785424
111Fatty acid biosynthesis_Homo sapiens_hsa000610.55815016
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55091809
113Prolactin signaling pathway_Homo sapiens_hsa049170.54624706
114RNA polymerase_Homo sapiens_hsa030200.54224385
115Lysine degradation_Homo sapiens_hsa003100.53428229
116Pyruvate metabolism_Homo sapiens_hsa006200.52185334
117RNA degradation_Homo sapiens_hsa030180.51713617
118Pancreatic cancer_Homo sapiens_hsa052120.50091069
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49853315
120Insulin signaling pathway_Homo sapiens_hsa049100.48628590
121Homologous recombination_Homo sapiens_hsa034400.48247861
122Hippo signaling pathway_Homo sapiens_hsa043900.47796647
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47348386
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47231348
125Melanoma_Homo sapiens_hsa052180.46215209
126Fatty acid metabolism_Homo sapiens_hsa012120.46117859
127Tight junction_Homo sapiens_hsa045300.44720248
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39731633
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39542507
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39380088
131Endocytosis_Homo sapiens_hsa041440.36336260
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36265979
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35960349
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34678925
135Thyroid cancer_Homo sapiens_hsa052160.33042300
136Hedgehog signaling pathway_Homo sapiens_hsa043400.32278462
137FoxO signaling pathway_Homo sapiens_hsa040680.32048409
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29931687
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29415121

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