USP47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.23085565
2acrosome assembly (GO:0001675)4.76126733
3presynaptic membrane assembly (GO:0097105)4.39042382
4fusion of sperm to egg plasma membrane (GO:0007342)4.26529831
5pyrimidine nucleobase catabolic process (GO:0006208)4.25725817
6plasma membrane repair (GO:0001778)4.19394557
7peptidyl-lysine dimethylation (GO:0018027)3.88896261
8presynaptic membrane organization (GO:0097090)3.81034468
9negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.73061800
10nuclear pore complex assembly (GO:0051292)3.72117192
11postsynaptic membrane organization (GO:0001941)3.63423020
12cytoplasmic mRNA processing body assembly (GO:0033962)3.62324402
13sperm-egg recognition (GO:0035036)3.61499175
14neuron cell-cell adhesion (GO:0007158)3.54633152
15axonal fasciculation (GO:0007413)3.54403970
16sperm motility (GO:0030317)3.53227572
17otic vesicle formation (GO:0030916)3.50213886
18actin-myosin filament sliding (GO:0033275)3.50091851
19muscle filament sliding (GO:0030049)3.50091851
20cell wall macromolecule metabolic process (GO:0044036)3.49888112
21cell wall macromolecule catabolic process (GO:0016998)3.49888112
22cerebral cortex radially oriented cell migration (GO:0021799)3.46805249
23mitotic sister chromatid cohesion (GO:0007064)3.46052761
24genitalia morphogenesis (GO:0035112)3.40568791
25nucleobase catabolic process (GO:0046113)3.38501919
26insulin-like growth factor receptor signaling pathway (GO:0048009)3.34186450
27cardiac myofibril assembly (GO:0055003)3.33563101
28hippo signaling (GO:0035329)3.32450143
29neuron recognition (GO:0008038)3.31262547
30cell-cell recognition (GO:0009988)3.29136015
31carnitine transmembrane transport (GO:1902603)3.29105020
32piRNA metabolic process (GO:0034587)3.28758729
33central nervous system projection neuron axonogenesis (GO:0021952)3.28548176
34binding of sperm to zona pellucida (GO:0007339)3.28263894
35NLS-bearing protein import into nucleus (GO:0006607)3.24675746
36multicellular organism reproduction (GO:0032504)3.23529969
37synaptonemal complex assembly (GO:0007130)3.21708705
38limb bud formation (GO:0060174)3.20762030
39plasma membrane fusion (GO:0045026)3.20493146
40negative regulation of potassium ion transmembrane transport (GO:1901380)3.19742713
41carnitine shuttle (GO:0006853)3.18473669
42male meiosis (GO:0007140)3.18398826
43regulation of RNA export from nucleus (GO:0046831)3.18025962
44vocalization behavior (GO:0071625)3.16477329
45neurotransmitter-gated ion channel clustering (GO:0072578)3.16114836
46carnitine transport (GO:0015879)3.15877093
47amino-acid betaine transport (GO:0015838)3.15877093
48synaptonemal complex organization (GO:0070193)3.15449700
49macroautophagy (GO:0016236)3.13387895
50actin-mediated cell contraction (GO:0070252)3.09795960
51regulation of sarcomere organization (GO:0060297)3.07531452
52sarcomere organization (GO:0045214)3.06867753
53regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.06396740
54dendritic spine morphogenesis (GO:0060997)3.06362876
55nuclear pore organization (GO:0006999)3.05401593
56protein targeting to Golgi (GO:0000042)3.04597383
57fatty acid transmembrane transport (GO:1902001)3.02720217
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02117726
59regulation of skeletal muscle contraction (GO:0014819)3.00703884
60positive regulation of fatty acid beta-oxidation (GO:0032000)2.99985607
61negative regulation of DNA repair (GO:0045738)2.97154523
62actin filament-based movement (GO:0030048)2.96258542
63myofibril assembly (GO:0030239)2.95432089
64central nervous system neuron axonogenesis (GO:0021955)2.91409299
65retrograde transport, vesicle recycling within Golgi (GO:0000301)2.88901369
66regulation of fatty acid beta-oxidation (GO:0031998)2.88821825
67negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83798539
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.82768807
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.82526025
70regulation of relaxation of muscle (GO:1901077)2.81580304
71dendrite morphogenesis (GO:0048813)2.79657498
72reproduction (GO:0000003)2.77659306
73regulation of cell communication by electrical coupling (GO:0010649)2.76754581
74coronary vasculature morphogenesis (GO:0060977)2.74014721
75gene silencing by RNA (GO:0031047)2.73046300
76spermatid development (GO:0007286)2.70841547
77establishment of mitochondrion localization (GO:0051654)2.68992681
78interkinetic nuclear migration (GO:0022027)2.68987460
79negative regulation of cell size (GO:0045792)2.68707572
80retinal ganglion cell axon guidance (GO:0031290)2.68545652
81olfactory bulb development (GO:0021772)2.67896640
82epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.67365186
83positive regulation of glycogen biosynthetic process (GO:0045725)2.67261948
84regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.66214162
85regulation of nucleobase-containing compound transport (GO:0032239)2.66121548
86regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.65885105
87positive regulation of cardiac muscle cell differentiation (GO:2000727)2.65347808
88nucleus localization (GO:0051647)2.64551431
89startle response (GO:0001964)2.64482196
90microtubule anchoring (GO:0034453)2.63839217
91cerebral cortex cell migration (GO:0021795)2.63668276
92regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.62740279
93regulation of protein polyubiquitination (GO:1902914)2.61774320
94axon extension involved in axon guidance (GO:0048846)2.60793804
95neuron projection extension involved in neuron projection guidance (GO:1902284)2.60793804
96Golgi transport vesicle coating (GO:0048200)2.60299107
97COPI coating of Golgi vesicle (GO:0048205)2.60299107
98glucocorticoid receptor signaling pathway (GO:0042921)2.59528798
99organelle transport along microtubule (GO:0072384)2.59510675
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.58244479
101negative regulation of neurotransmitter transport (GO:0051589)2.58208116
102dorsal/ventral axis specification (GO:0009950)2.57022677
103regulation of axon guidance (GO:1902667)2.56997033
104negative regulation of fatty acid transport (GO:2000192)2.56277746
105neural tube formation (GO:0001841)2.55922349
106establishment of nucleus localization (GO:0040023)2.53999013
107positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.53087383
108regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.52881208
109lysine metabolic process (GO:0006553)2.52881059
110lysine catabolic process (GO:0006554)2.52881059
111auditory behavior (GO:0031223)2.52309576
112actomyosin structure organization (GO:0031032)2.52294163
113ionotropic glutamate receptor signaling pathway (GO:0035235)2.51462459
114midgut development (GO:0007494)2.50631251
115negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.50522608
116negative regulation of organelle assembly (GO:1902116)2.49844406
117regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.49650663
118positive regulation of glycolytic process (GO:0045821)2.49374567
119regulation of short-term neuronal synaptic plasticity (GO:0048172)2.46797646
120cardiac muscle cell development (GO:0055013)2.45776127
121positive regulation of potassium ion transport (GO:0043268)2.44826471
122protein localization to Golgi apparatus (GO:0034067)2.44602776
123cell adhesion mediated by integrin (GO:0033627)2.44182581
124growth hormone receptor signaling pathway (GO:0060396)2.43310786
125embryonic foregut morphogenesis (GO:0048617)2.43089505
126positive regulation of synapse assembly (GO:0051965)2.42749598
127protein hydroxylation (GO:0018126)2.42307085
128skeletal muscle adaptation (GO:0043501)2.42133569
129embryonic retina morphogenesis in camera-type eye (GO:0060059)2.41499229
130regulation of synapse assembly (GO:0051963)2.41368938
131positive regulation of histone deacetylation (GO:0031065)2.41341316
132cardiac ventricle formation (GO:0003211)2.41253552
133collagen fibril organization (GO:0030199)2.41017667
134protein localization to synapse (GO:0035418)2.40200327
135vesicle transport along microtubule (GO:0047496)2.40021176
136epithelial cilium movement (GO:0003351)2.39198062
137inner ear receptor stereocilium organization (GO:0060122)2.39025311
138axon extension (GO:0048675)2.38939385
139regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.38572796
140negative regulation of axon guidance (GO:1902668)2.38543832
141positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.37819396
142negative regulation of neurotransmitter secretion (GO:0046929)2.37694131
143positive regulation of glycogen metabolic process (GO:0070875)2.37443921
144regulation of dendritic spine development (GO:0060998)2.37114601
145RNA stabilization (GO:0043489)2.36793498
146mRNA stabilization (GO:0048255)2.36793498
147phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.36047727
148positive regulation of neurological system process (GO:0031646)2.35850832
149gastrulation with mouth forming second (GO:0001702)2.35658015
150regulation of pigment cell differentiation (GO:0050932)2.35161681
151pore complex assembly (GO:0046931)2.35027198
152synapse assembly (GO:0007416)2.34959154
153positive regulation of cardiac muscle hypertrophy (GO:0010613)2.34679666
154positive regulation of muscle hypertrophy (GO:0014742)2.34679666
155positive regulation of dendritic spine morphogenesis (GO:0061003)2.34405966
156intraciliary transport (GO:0042073)2.33810027
157corticosteroid receptor signaling pathway (GO:0031958)2.33758597
158body morphogenesis (GO:0010171)2.32958729
159glutamate receptor signaling pathway (GO:0007215)2.32752156
160positive regulation of fatty acid oxidation (GO:0046321)2.32170961
161epithelial cell differentiation involved in kidney development (GO:0035850)2.32153635
162establishment of protein localization to Golgi (GO:0072600)2.31961423
163endocardial cushion development (GO:0003197)2.31789419
164cardiac chamber formation (GO:0003207)2.31025873
165cardiac cell development (GO:0055006)2.30965780
166adherens junction assembly (GO:0034333)2.30808970
167cyclic nucleotide catabolic process (GO:0009214)2.30603587
168alpha-linolenic acid metabolic process (GO:0036109)2.30320461
169negative regulation of heart growth (GO:0061117)2.28955823
170negative regulation of cardiac muscle tissue growth (GO:0055022)2.28955823
171positive regulation of hormone biosynthetic process (GO:0046886)2.28595733
172hindbrain development (GO:0030902)2.28541308
173righting reflex (GO:0060013)2.27983967
174apoptotic cell clearance (GO:0043277)2.27686282
1754-hydroxyproline metabolic process (GO:0019471)2.27544908
176calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.27369403
177regulation of dendritic spine morphogenesis (GO:0061001)2.27277870
178gamma-aminobutyric acid transport (GO:0015812)2.26738184
179regulation of actin filament-based movement (GO:1903115)2.26648942
180photoreceptor cell differentiation (GO:0046530)2.26190494
181eye photoreceptor cell differentiation (GO:0001754)2.26190494
182regulation of axon extension involved in axon guidance (GO:0048841)2.25982996
183forebrain neuron differentiation (GO:0021879)2.25897106
184nerve growth factor signaling pathway (GO:0038180)2.24207755
185negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.23623199
186neuronal action potential propagation (GO:0019227)2.23283392
187vascular smooth muscle contraction (GO:0014829)2.21178061
188sarcoplasmic reticulum calcium ion transport (GO:0070296)2.20857567
189regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.20266424
190regulation of membrane repolarization (GO:0060306)2.19956770
191regulation of collateral sprouting (GO:0048670)2.19328480
192cAMP catabolic process (GO:0006198)2.18797208

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.66162715
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.34506315
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14093080
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.98988866
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.86928675
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66154071
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.61832477
8IGF1R_20145208_ChIP-Seq_DFB_Human2.60380575
9TAF15_26573619_Chip-Seq_HEK293_Human2.43525549
10FUS_26573619_Chip-Seq_HEK293_Human2.40875121
11ZNF274_21170338_ChIP-Seq_K562_Hela2.26204860
12CLOCK_20551151_ChIP-Seq_293T_Human2.25743710
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.17036536
14PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.08602458
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07319572
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.05058681
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.00824446
18SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.00341109
19* SMAD4_21799915_ChIP-Seq_A2780_Human1.99437840
20P300_19829295_ChIP-Seq_ESCs_Human1.98782401
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98691981
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.98013482
23* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.97632467
24LXR_22158963_ChIP-Seq_LIVER_Mouse1.92859763
25* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92207084
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.91391476
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89130526
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.87954235
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87411652
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.85854364
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84207600
32EWS_26573619_Chip-Seq_HEK293_Human1.82191099
33VDR_22108803_ChIP-Seq_LS180_Human1.79197852
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76240961
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75807628
36* TBX20_22328084_ChIP-Seq_HEART_Mouse1.72588541
37* TBX20_22080862_ChIP-Seq_HEART_Mouse1.72588541
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.70872922
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68210604
40STAT3_23295773_ChIP-Seq_U87_Human1.65852160
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65217397
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.64740636
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.62241018
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61803064
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60644220
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60587255
47* CBX2_27304074_Chip-Seq_ESCs_Mouse1.59184297
48HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.57927284
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57726295
50* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57271060
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.56194516
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55953422
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55921277
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.55767394
55* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55118237
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55065849
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.54730389
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54667074
59BRD4_25478319_ChIP-Seq_HGPS_Human1.53449902
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52473076
61RNF2_27304074_Chip-Seq_NSC_Mouse1.51929949
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.51011953
63PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50484393
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.49156525
65* AR_25329375_ChIP-Seq_VCAP_Human1.48584767
66FOXA2_19822575_ChIP-Seq_HepG2_Human1.47788824
67RXR_22158963_ChIP-Seq_LIVER_Mouse1.47679989
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47566575
69* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47331573
70* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47025827
71* TCF4_23295773_ChIP-Seq_U87_Human1.46955153
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46882069
73* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44681345
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44439214
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43796155
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.43489326
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42910304
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42910304
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41469203
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41212518
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40708596
82CJUN_26792858_Chip-Seq_BT549_Human1.38635805
83ER_23166858_ChIP-Seq_MCF-7_Human1.38041476
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37524333
85* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36669724
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.36654359
87PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35829633
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35288933
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34193134
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.32039118
91AR_21572438_ChIP-Seq_LNCaP_Human1.31834512
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.31697326
93P53_22387025_ChIP-Seq_ESCs_Mouse1.30445698
94* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30421465
95BCAT_22108803_ChIP-Seq_LS180_Human1.30302384
96RUNX2_22187159_ChIP-Seq_PCA_Human1.28123481
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27173998
98FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.26531482
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25732556
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.23842914
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.23658332
102EZH2_27304074_Chip-Seq_ESCs_Mouse1.23533773
103CBP_20019798_ChIP-Seq_JUKART_Human1.23208068
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23208068
105* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22340515
106TP53_16413492_ChIP-PET_HCT116_Human1.21582186
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.21243084
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21053812
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19663815
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18724115
111SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18485821
112SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18348607
113PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17801119
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16340883
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16128099
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15561581
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14185537
118HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14045262
119SOX9_26525672_Chip-Seq_HEART_Mouse1.13938545
120WT1_19549856_ChIP-ChIP_CCG9911_Human1.13518072
121JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13412170
122* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13389090
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12663079
124* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12036699
125* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11506928
126KDM2B_26808549_Chip-Seq_REH_Human1.11308177
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10518009
128EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10327079
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10095483
130SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09738468
131SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09738468
132CRX_20693478_ChIP-Seq_RETINA_Mouse1.09245185
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08582858
134TAL1_26923725_Chip-Seq_HPCs_Mouse1.08169952
135NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07614874
136CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07542930
137* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05715300
138TCF7_22412390_ChIP-Seq_EML_Mouse1.05586810
139ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05353635
140* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05347115
141ARNT_22903824_ChIP-Seq_MCF-7_Human1.04511950
142TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03055121
143FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02977726
144SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02336637
145NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00311577
146NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00311577
147EZH2_22144423_ChIP-Seq_EOC_Human1.00116802
148* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99297590
149PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98296649
150FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98148460
151ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97323658
152FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96997576
153* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95420279
154TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94819747
155CDX2_22108803_ChIP-Seq_LS180_Human0.92696874
156SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92573606
157* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92503402
158* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91951042
159SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91771839
160* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91344569
161RUNX1_27514584_Chip-Seq_MCF-7_Human0.91281801
162* UBF1/2_26484160_Chip-Seq_HMECs_Human0.90589791
163* KDM2B_26808549_Chip-Seq_DND41_Human0.89734022
164GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.89091453
165AR_21909140_ChIP-Seq_LNCAP_Human0.87407607
166TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.86968370
167* TP63_23658742_ChIP-Seq_EP156T_Human0.86285705
168POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85231494
169SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85072045
170* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84688527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.91189939
2MP0003880_abnormal_central_pattern3.49372495
3MP0008438_abnormal_cutaneous_collagen3.23449852
4MP0005410_abnormal_fertilization2.88472918
5MP0000569_abnormal_digit_pigmentation2.82772407
6MP0000778_abnormal_nervous_system2.50648211
7MP0005423_abnormal_somatic_nervous2.41203725
8MP0004859_abnormal_synaptic_plasticity2.36607015
9MP0004270_analgesia2.36434722
10MP0000751_myopathy2.29479991
11MP0004130_abnormal_muscle_cell2.18391721
12MP0004084_abnormal_cardiac_muscle2.16942095
13MP0005076_abnormal_cell_differentiation2.15431337
14MP0000733_abnormal_muscle_development2.09930130
15MP0004087_abnormal_muscle_fiber2.07096779
16MP0005623_abnormal_meninges_morphology2.05457993
17MP0002837_dystrophic_cardiac_calcinosis2.03656659
18MP0005275_abnormal_skin_tensile1.99934907
19MP0003787_abnormal_imprinting1.98723351
20MP0004233_abnormal_muscle_weight1.96396135
21MP0010352_gastrointestinal_tract_polyps1.94382201
22MP0004036_abnormal_muscle_relaxation1.87217019
23MP0000537_abnormal_urethra_morphology1.87136336
24MP0003122_maternal_imprinting1.85957824
25MP0002139_abnormal_hepatobiliary_system1.85122434
26MP0009384_cardiac_valve_regurgitation1.80605031
27MP0002102_abnormal_ear_morphology1.80562156
28MP0000749_muscle_degeneration1.80203654
29MP0004272_abnormal_basement_membrane1.79673727
30MP0006276_abnormal_autonomic_nervous1.78313691
31MP0001984_abnormal_olfaction1.76560065
32MP0001486_abnormal_startle_reflex1.74827042
33MP0003252_abnormal_bile_duct1.74440094
34MP0005503_abnormal_tendon_morphology1.72592420
35MP0003635_abnormal_synaptic_transmissio1.72133118
36MP0006054_spinal_hemorrhage1.70912574
37MP0010234_abnormal_vibrissa_follicle1.70427549
38MP0003646_muscle_fatigue1.69503469
39MP0009053_abnormal_anal_canal1.68787182
40MP0003300_gastrointestinal_ulcer1.68053514
41MP0003121_genomic_imprinting1.65509886
42MP0001529_abnormal_vocalization1.63439975
43MP0002272_abnormal_nervous_system1.61278552
44MP0010630_abnormal_cardiac_muscle1.59558437
45MP0006292_abnormal_olfactory_placode1.58470665
46MP0005666_abnormal_adipose_tissue1.58236575
47MP0002269_muscular_atrophy1.57822587
48MP0004145_abnormal_muscle_electrophysio1.55074580
49MP0004185_abnormal_adipocyte_glucose1.51885025
50MP0002063_abnormal_learning/memory/cond1.50209079
51MP0002638_abnormal_pupillary_reflex1.47555345
52MP0000759_abnormal_skeletal_muscle1.47476402
53MP0009046_muscle_twitch1.45998779
54MP0003566_abnormal_cell_adhesion1.44771976
55MP0001299_abnormal_eye_distance/1.44372630
56MP0000631_abnormal_neuroendocrine_gland1.43757976
57MP0005620_abnormal_muscle_contractility1.43053215
58MP0002736_abnormal_nociception_after1.42018835
59MP0002877_abnormal_melanocyte_morpholog1.41470772
60MP0002734_abnormal_mechanical_nocicepti1.40719627
61MP0002106_abnormal_muscle_physiology1.39642929
62MP0009745_abnormal_behavioral_response1.38347682
63MP0005248_abnormal_Harderian_gland1.38172823
64MP0003890_abnormal_embryonic-extraembry1.37969068
65MP0003385_abnormal_body_wall1.36481174
66MP0000747_muscle_weakness1.35622048
67MP0002009_preneoplasia1.33621104
68MP0005187_abnormal_penis_morphology1.32528599
69MP0005367_renal/urinary_system_phenotyp1.31350108
70MP0000516_abnormal_urinary_system1.31350108
71MP0003279_aneurysm1.30096319
72MP0005386_behavior/neurological_phenoty1.29688307
73MP0004924_abnormal_behavior1.29688307
74MP0002108_abnormal_muscle_morphology1.29002858
75MP0002067_abnormal_sensory_capabilities1.28561543
76MP0000750_abnormal_muscle_regeneration1.26948172
77MP0000955_abnormal_spinal_cord1.25633662
78MP0002572_abnormal_emotion/affect_behav1.25465205
79MP0002234_abnormal_pharynx_morphology1.25427273
80MP0003091_abnormal_cell_migration1.25101304
81MP0009780_abnormal_chondrocyte_physiolo1.24920766
82MP0002896_abnormal_bone_mineralization1.23543957
83MP0005375_adipose_tissue_phenotype1.20933523
84MP0005369_muscle_phenotype1.20897090
85MP0002184_abnormal_innervation1.20082500
86MP0004197_abnormal_fetal_growth/weight/1.19202341
87MP0003045_fibrosis1.18940468
88MP0005551_abnormal_eye_electrophysiolog1.18565874
89MP0002233_abnormal_nose_morphology1.18317822
90MP0001968_abnormal_touch/_nociception1.18146401
91MP0002735_abnormal_chemical_nociception1.18036428
92MP0003115_abnormal_respiratory_system1.17748930
93MP0000428_abnormal_craniofacial_morphol1.15507750
94MP0010307_abnormal_tumor_latency1.14611470
95MP0002064_seizures1.14474242
96MP0003950_abnormal_plasma_membrane1.14360770
97MP0004885_abnormal_endolymph1.14175238
98MP0005171_absent_coat_pigmentation1.13785028
99MP0004142_abnormal_muscle_tone1.13743899
100MP0002882_abnormal_neuron_morphology1.13419276
101MP0004085_abnormal_heartbeat1.13130855
102MP0006072_abnormal_retinal_apoptosis1.12849477
103MP0005253_abnormal_eye_physiology1.12390845
104MP0005360_urolithiasis1.12130434
105MP0002282_abnormal_trachea_morphology1.12085579
106MP0001177_atelectasis1.11723465
107MP0004811_abnormal_neuron_physiology1.11585392
108MP0005330_cardiomyopathy1.11279417
109MP0005645_abnormal_hypothalamus_physiol1.10905178
110MP0002557_abnormal_social/conspecific_i1.10277857
111MP0003698_abnormal_male_reproductive1.10267923
112MP0003755_abnormal_palate_morphology1.09951206
113MP0002972_abnormal_cardiac_muscle1.09457074
114MP0008877_abnormal_DNA_methylation1.09256309
115MP0006138_congestive_heart_failure1.08671837
116MP0008057_abnormal_DNA_replication1.07910172
117MP0001929_abnormal_gametogenesis1.04868788
118MP0002822_catalepsy1.03887182
119MP0003935_abnormal_craniofacial_develop1.03817846
120MP0000266_abnormal_heart_morphology1.02154164
121MP0009672_abnormal_birth_weight1.01943569
122MP0008995_early_reproductive_senescence1.00836994
123MP0000003_abnormal_adipose_tissue1.00736793
124MP0005365_abnormal_bile_salt0.98385888
125MP0004215_abnormal_myocardial_fiber0.98175773
126MP0001958_emphysema0.98121244
127MP0002925_abnormal_cardiovascular_devel0.96497363
128MP0002152_abnormal_brain_morphology0.96150154
129MP0009703_decreased_birth_body0.95687372
130MP0003137_abnormal_impulse_conducting0.94650496
131MP0000383_abnormal_hair_follicle0.94411606
132MP0002128_abnormal_blood_circulation0.94082430
133MP0002971_abnormal_brown_adipose0.93980719
134MP0008775_abnormal_heart_ventricle0.93543138
135MP0002752_abnormal_somatic_nervous0.92038132
136MP0000013_abnormal_adipose_tissue0.91060497
137MP0001544_abnormal_cardiovascular_syste0.90784888
138MP0005385_cardiovascular_system_phenoty0.90784888
139MP0003567_abnormal_fetal_cardiomyocyte0.90780553
140MP0003937_abnormal_limbs/digits/tail_de0.89748749
141MP0003861_abnormal_nervous_system0.89152197
142MP0002084_abnormal_developmental_patter0.89034450
143MP0003942_abnormal_urinary_system0.88578995
144MP0002653_abnormal_ependyma_morphology0.87373194
145MP0000767_abnormal_smooth_muscle0.87357743
146MP0003221_abnormal_cardiomyocyte_apopto0.87303619
147MP0010368_abnormal_lymphatic_system0.87203232
148MP0002088_abnormal_embryonic_growth/wei0.86911919
149MP0010386_abnormal_urinary_bladder0.86453807
150MP0004484_altered_response_of0.86354793
151MP0001879_abnormal_lymphatic_vessel0.85908536
152MP0009250_abnormal_appendicular_skeleto0.85733189
153MP0001188_hyperpigmentation0.85420103
154MP0003984_embryonic_growth_retardation0.85386118
155MP0001293_anophthalmia0.85203247
156MP0010030_abnormal_orbit_morphology0.84732810
157MP0000647_abnormal_sebaceous_gland0.84728438
158MP0002066_abnormal_motor_capabilities/c0.83693744
159MP0002697_abnormal_eye_size0.83230672
160MP0008961_abnormal_basal_metabolism0.82892036
161MP0000427_abnormal_hair_cycle0.81848988
162MP0003868_abnormal_feces_composition0.81826100
163MP0010329_abnormal_lipoprotein_level0.80140345
164MP0008569_lethality_at_weaning0.79659942
165MP0005023_abnormal_wound_healing0.79151441
166MP0003123_paternal_imprinting0.78973223
167MP0003136_yellow_coat_color0.78840840
168MP0002928_abnormal_bile_duct0.78349353
169MP0002086_abnormal_extraembryonic_tissu0.78337871
170MP0003633_abnormal_nervous_system0.78093849
171MP0002127_abnormal_cardiovascular_syste0.76599861

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)3.97736420
2Exercise-induced muscle cramps (HP:0003710)3.88563126
3Hyperventilation (HP:0002883)3.83415765
4Volvulus (HP:0002580)3.68981312
5Hyporeflexia of lower limbs (HP:0002600)3.51289773
6Muscle fiber inclusion bodies (HP:0100299)3.45507204
7Exercise-induced myalgia (HP:0003738)3.43092461
8Increased connective tissue (HP:0009025)3.40452327
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.39466495
10Drooling (HP:0002307)3.37048812
11Difficulty running (HP:0009046)3.26766392
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.16943359
13Gait imbalance (HP:0002141)3.14816877
14Excessive salivation (HP:0003781)3.03392544
15Broad-based gait (HP:0002136)3.02834958
16Protrusio acetabuli (HP:0003179)2.89873843
17Nemaline bodies (HP:0003798)2.83676156
18Congenital primary aphakia (HP:0007707)2.83518637
19Fetal akinesia sequence (HP:0001989)2.83363857
20Aortic aneurysm (HP:0004942)2.78448514
21Medial flaring of the eyebrow (HP:0010747)2.78221192
22Subacute progressive viral hepatitis (HP:0006572)2.76534784
23Difficulty climbing stairs (HP:0003551)2.75208690
24Calf muscle hypertrophy (HP:0008981)2.73174023
25Abnormality of the left ventricular outflow tract (HP:0011103)2.69735410
26Subaortic stenosis (HP:0001682)2.69735410
27Cerebral aneurysm (HP:0004944)2.66891467
28Focal motor seizures (HP:0011153)2.65791571
29Short 4th metacarpal (HP:0010044)2.63412549
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.63412549
31Bell-shaped thorax (HP:0001591)2.60550711
32Muscle hypertrophy of the lower extremities (HP:0008968)2.58014669
33Myoglobinuria (HP:0002913)2.57533864
34Focal seizures (HP:0007359)2.55085539
35Nephrogenic diabetes insipidus (HP:0009806)2.54028594
36Round ear (HP:0100830)2.53903432
37Muscle fiber splitting (HP:0003555)2.53126431
38Shallow orbits (HP:0000586)2.52989132
39Absent/shortened dynein arms (HP:0200106)2.49650729
40Dynein arm defect of respiratory motile cilia (HP:0012255)2.49650729
41Abnormality of the lower motor neuron (HP:0002366)2.47747730
42Febrile seizures (HP:0002373)2.47166759
43Hypoplastic ischia (HP:0003175)2.45475631
44Genital tract atresia (HP:0001827)2.45395242
45Intestinal atresia (HP:0011100)2.44604064
46Long clavicles (HP:0000890)2.44289563
47Ulnar deviation of the wrist (HP:0003049)2.39616053
48Limb dystonia (HP:0002451)2.39132298
49Vaginal atresia (HP:0000148)2.38851724
50Abnormality of the calf musculature (HP:0001430)2.38351361
51Poor coordination (HP:0002370)2.36836243
52Distal arthrogryposis (HP:0005684)2.36323900
53Mildly elevated creatine phosphokinase (HP:0008180)2.36270460
54Abnormality of the 4th metacarpal (HP:0010012)2.35616758
55Optic nerve hypoplasia (HP:0000609)2.35563573
56Oligodactyly (hands) (HP:0001180)2.34380517
57Abnormal hair whorl (HP:0010721)2.31793587
58Aortic dissection (HP:0002647)2.31039589
59Lymphangioma (HP:0100764)2.30082343
60Absent speech (HP:0001344)2.29962272
61True hermaphroditism (HP:0010459)2.27569149
62Abnormal finger flexion creases (HP:0006143)2.27311070
63Abnormality of the ischium (HP:0003174)2.27062687
64Scapular winging (HP:0003691)2.26521435
65Mitral valve prolapse (HP:0001634)2.26474713
66Premature rupture of membranes (HP:0001788)2.23441491
67Right ventricular cardiomyopathy (HP:0011663)2.22294861
68Limb-girdle muscle weakness (HP:0003325)2.21333289
69Asymmetric septal hypertrophy (HP:0001670)2.20530289
70Gaze-evoked nystagmus (HP:0000640)2.20011325
71Urinary urgency (HP:0000012)2.19698769
72Aneurysm (HP:0002617)2.19086014
73Frequent falls (HP:0002359)2.16703735
74Increased density of long bones (HP:0006392)2.15847878
75Septo-optic dysplasia (HP:0100842)2.15294406
76Pelvic girdle muscle weakness (HP:0003749)2.15288794
77Absent frontal sinuses (HP:0002688)2.14032558
78Sudden death (HP:0001699)2.13292378
79Spinal rigidity (HP:0003306)2.11193110
80Increased variability in muscle fiber diameter (HP:0003557)2.11130391
81Absent phalangeal crease (HP:0006109)2.11017454
82Broad metatarsal (HP:0001783)2.10918489
83Nephronophthisis (HP:0000090)2.10823816
84Hepatoblastoma (HP:0002884)2.10589016
85Renal cortical cysts (HP:0000803)2.10294072
86Molar tooth sign on MRI (HP:0002419)2.10144040
87Abnormality of midbrain morphology (HP:0002418)2.10144040
88EMG: myopathic abnormalities (HP:0003458)2.09196809
89Shoulder girdle muscle weakness (HP:0003547)2.08311833
90Limited hip movement (HP:0008800)2.07680983
91Protruding tongue (HP:0010808)2.06629296
92Abnormality of skeletal muscle fiber size (HP:0012084)2.05496999
93Rectal prolapse (HP:0002035)2.04371552
94Myopathic facies (HP:0002058)2.03985821
95Heterotopia (HP:0002282)2.02693253
96Macroorchidism (HP:0000053)2.01562622
97Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.01293899
98Ankle contracture (HP:0006466)2.00989654
99Exotropia (HP:0000577)2.00808208
100Chronic hepatic failure (HP:0100626)2.00391829
101Buphthalmos (HP:0000557)1.99968962
102Abnormality of the renal medulla (HP:0100957)1.99742222
103Specific learning disability (HP:0001328)1.98277526
104Abnormality of the calcaneus (HP:0008364)1.98166388
105Tubulointerstitial nephritis (HP:0001970)1.97949396
106Atonic seizures (HP:0010819)1.97413428
107Hip contracture (HP:0003273)1.96383152
108Bladder diverticulum (HP:0000015)1.96331306
109Dilatation of the ascending aorta (HP:0005111)1.96065181
110Abnormality of the corticospinal tract (HP:0002492)1.95857862
111Short foot (HP:0001773)1.93869150
112Abnormality of the musculature of the pelvis (HP:0001469)1.93821626
113Abnormality of the hip-girdle musculature (HP:0001445)1.93821626
114Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.93752373
115Degeneration of the lateral corticospinal tracts (HP:0002314)1.93752373
116Microglossia (HP:0000171)1.93555740
117Hip dysplasia (HP:0001385)1.93181199
118Papillary thyroid carcinoma (HP:0002895)1.91630548
119Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.91190624
120Cortical dysplasia (HP:0002539)1.90473773
121Long toe (HP:0010511)1.90294019
122Renovascular hypertension (HP:0100817)1.89127466
123Exostoses (HP:0100777)1.88094588
124Rimmed vacuoles (HP:0003805)1.87950057
125Abnormality of salivation (HP:0100755)1.86995477
126Lower limb muscle weakness (HP:0007340)1.85045616
127Hypoalphalipoproteinemia (HP:0003233)1.84970224
128Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84562384
129Calcaneovalgus deformity (HP:0001848)1.83942925
130Amyotrophic lateral sclerosis (HP:0007354)1.83851091
131Large earlobe (HP:0009748)1.81827811
132Fair hair (HP:0002286)1.79470973
133Cystic hygroma (HP:0000476)1.78704105
134Truncal obesity (HP:0001956)1.78456290
135Facial diplegia (HP:0001349)1.78001567
136Proximal amyotrophy (HP:0007126)1.77860525
137Blue irides (HP:0000635)1.76551865
138Shawl scrotum (HP:0000049)1.76311267
139Abnormality of the renal cortex (HP:0011035)1.74810255
140Rhabdomyolysis (HP:0003201)1.74766101
141Postaxial hand polydactyly (HP:0001162)1.74717422
142Nasal polyposis (HP:0100582)1.74532776
143Decreased lacrimation (HP:0000633)1.73935710
144Back pain (HP:0003418)1.73496338
145Action tremor (HP:0002345)1.73163112
146Wrist flexion contracture (HP:0001239)1.72778786
147Aplasia/Hypoplasia of the lens (HP:0008063)1.71820752
148Micropenis (HP:0000054)1.71138565
149Neoplasm of the oral cavity (HP:0100649)1.70513370
150Epileptic encephalopathy (HP:0200134)1.70198828
151Bowel diverticulosis (HP:0005222)1.69367373
152Overgrowth (HP:0001548)1.68740476
153Bundle branch block (HP:0011710)1.68706552
154Deep venous thrombosis (HP:0002625)1.68705421
155Broad foot (HP:0001769)1.68302897
156Lipoatrophy (HP:0100578)1.68176884
157Impaired vibration sensation in the lower limbs (HP:0002166)1.67817553
158Progressive cerebellar ataxia (HP:0002073)1.66991817
159Abnormality of the labia minora (HP:0012880)1.66718191
160Left ventricular hypertrophy (HP:0001712)1.65909691
161Aplasia/Hypoplasia of the tibia (HP:0005772)1.65708910
162Thyroid carcinoma (HP:0002890)1.64965900
163Hyperacusis (HP:0010780)1.64368694
164Pachygyria (HP:0001302)1.64048670
165Pancreatic cysts (HP:0001737)1.63989333
166Epileptiform EEG discharges (HP:0011182)1.63866885
167Growth hormone deficiency (HP:0000824)1.63863009
168Asymmetry of the thorax (HP:0001555)1.63803804
169Complete atrioventricular canal defect (HP:0001674)1.63315089
170EEG with generalized epileptiform discharges (HP:0011198)1.63191199
171Submucous cleft hard palate (HP:0000176)1.62930087
172Mesomelia (HP:0003027)1.62068210
173Deformed tarsal bones (HP:0008119)1.61999077
174Chronic bronchitis (HP:0004469)1.61452688
175Limb-girdle muscle atrophy (HP:0003797)1.61250393
176Enlarged penis (HP:0000040)1.60695241
177Abnormal respiratory motile cilium physiology (HP:0012261)1.59646184
178High pitched voice (HP:0001620)1.59206052
179Deviation of the hallux (HP:0010051)1.58153818

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.18061564
2PDK44.07178616
3PDK34.07178616
4MARK13.88834852
5TTN3.88474004
6TRIB33.52077087
7LATS13.33898489
8PKN23.27923349
9PNCK2.62234553
10AKT32.50739090
11MAPK132.41341933
12MAP3K102.39986368
13PDGFRA2.36624113
14OBSCN2.32515514
15PDK22.28873505
16STK32.15748271
17RIPK12.11638394
18PTK62.00406793
19BCR1.99875770
20TNIK1.86651093
21WEE11.80440633
22WNK31.78273319
23FRK1.74211846
24PLK21.72847674
25PRKD31.69494502
26SIK11.64788099
27MAP2K71.64160224
28PINK11.60548242
29DDR21.55677936
30CDK121.53630342
31DMPK1.53550199
32NTRK31.50599203
33FGFR21.50309772
34MKNK21.48637346
35MAP4K21.40556136
36SGK21.38296306
37BMPR1B1.31788988
38CAMK1G1.31601242
39EEF2K1.31291846
40TESK11.29892179
41TRIM281.27749216
42EPHA41.27490267
43ICK1.25982693
44UHMK11.23694107
45LMTK21.22571560
46ERBB31.21892864
47NTRK21.19380774
48PDGFRB1.17890094
49PHKG21.16077530
50PHKG11.16077530
51SCYL21.13947683
52EIF2AK31.13816782
53STK38L1.13705579
54MTOR1.09731820
55FGFR11.08817348
56CDK61.08588841
57FGFR31.07957405
58NEK91.07793233
59CDC71.05144925
60PTK2B1.04688882
61CSNK1G21.03145217
62SGK2231.02002389
63SGK4941.02002389
64CAMK1D1.01188404
65EPHB20.98614240
66DYRK1B0.98030484
67PIK3CG0.96945471
68PIK3CA0.94764040
69PAK30.93716680
70MAP2K30.93681424
71CCNB10.93593508
72CAMKK20.91691978
73FGFR40.90849687
74PKN10.90738391
75TYRO30.89481094
76RET0.89154275
77LATS20.88635351
78CSNK1G10.88041643
79EPHA30.87052909
80STK240.85463052
81PAK20.85131203
82MKNK10.85075553
83NUAK10.84024131
84NEK10.83970198
85MAP3K70.83233487
86MAP2K40.80913728
87PAK60.80141922
88MINK10.78270936
89WNK10.78190505
90WNK40.77918270
91TRPM70.76438601
92NEK20.73880043
93CSNK1A1L0.73250522
94PRKCE0.73026901
95PTK20.72197295
96BRD40.72051773
97DYRK1A0.71676428
98FER0.70953109
99PRKAA10.68688555
100STK390.68671381
101STK380.67723677
102CAMK2A0.64905329
103CSNK1G30.64900476
104BMX0.62724674
105KSR10.61773131
106INSRR0.61080302
107MAP3K20.60678818
108YES10.58406473
109SGK10.57642438
110FLT30.57092058
111CDK50.56885947
112PRKCG0.55657545
113CAMK40.55250791
114DYRK20.55250030
115ROCK10.54902991
116EIF2AK20.53866465
117CAMK2B0.52824450
118PRKAA20.52061281
119ERBB20.50840597
120LRRK20.49798718
121MET0.48417642
122TGFBR10.48305848
123PRKG10.47844814
124SGK30.44759453
125JAK10.43979191
126CDK30.42514792
127STK110.41211040
128CSNK1D0.40908518
129RPS6KA40.40692191
130NLK0.40394603
131CSNK1E0.39808072
132MAP3K60.39638074
133PAK40.39279540
134PRKCH0.38954762
135PRKD10.38808557
136RPS6KA30.38794887
137BRSK20.38517335
138MELK0.38079163
139PLK40.37953086
140ERBB40.37901479
141ROCK20.37655623
142RPS6KB10.35475330
143ILK0.35441721
144ADRBK20.35435491
145ATM0.35334527
146PRKACB0.35235268
147MAP3K50.35146703
148CDC42BPA0.35084992
149* MAPK100.35081153
150ACVR1B0.34964218
151MST1R0.32874600
152GSK3A0.32706876
153CDK90.31434646
154CHEK10.31085579
155MAP3K40.30685695
156CDK40.30520245
157EGFR0.29648795
158MARK30.28361557
159STK100.27971918
160PDK10.27262025
161PRKDC0.26113441

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.91686029
2Circadian rhythm_Homo sapiens_hsa047102.73424228
3Lysine degradation_Homo sapiens_hsa003102.01623005
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.96540295
5Propanoate metabolism_Homo sapiens_hsa006401.94850832
6Fatty acid degradation_Homo sapiens_hsa000711.82419828
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.81464361
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79243659
9Dilated cardiomyopathy_Homo sapiens_hsa054141.74009899
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72760154
11Circadian entrainment_Homo sapiens_hsa047131.72529842
12Selenocompound metabolism_Homo sapiens_hsa004501.71851901
13GABAergic synapse_Homo sapiens_hsa047271.71692960
14Glucagon signaling pathway_Homo sapiens_hsa049221.71183749
15Glutamatergic synapse_Homo sapiens_hsa047241.69516170
16Adherens junction_Homo sapiens_hsa045201.68352785
17Dopaminergic synapse_Homo sapiens_hsa047281.68045954
18Focal adhesion_Homo sapiens_hsa045101.67834403
19Regulation of autophagy_Homo sapiens_hsa041401.65029217
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64114928
21Insulin resistance_Homo sapiens_hsa049311.59571010
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.57792323
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56470334
24Butanoate metabolism_Homo sapiens_hsa006501.55443601
25Morphine addiction_Homo sapiens_hsa050321.54745905
26Nitrogen metabolism_Homo sapiens_hsa009101.54606797
27Amphetamine addiction_Homo sapiens_hsa050311.51565473
28Axon guidance_Homo sapiens_hsa043601.51373051
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44614926
30Cocaine addiction_Homo sapiens_hsa050301.43464723
31Pyruvate metabolism_Homo sapiens_hsa006201.43409029
32PPAR signaling pathway_Homo sapiens_hsa033201.41099669
33ECM-receptor interaction_Homo sapiens_hsa045121.39341399
34Proteoglycans in cancer_Homo sapiens_hsa052051.39279431
35Viral myocarditis_Homo sapiens_hsa054161.39203126
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.34425038
37Fatty acid metabolism_Homo sapiens_hsa012121.33011869
38mTOR signaling pathway_Homo sapiens_hsa041501.31218697
39Taste transduction_Homo sapiens_hsa047421.29634383
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29147514
41AMPK signaling pathway_Homo sapiens_hsa041521.28916287
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27013293
43Small cell lung cancer_Homo sapiens_hsa052221.26009715
44Fatty acid biosynthesis_Homo sapiens_hsa000611.24091920
45Long-term depression_Homo sapiens_hsa047301.22972358
46Long-term potentiation_Homo sapiens_hsa047201.22549375
47Basal transcription factors_Homo sapiens_hsa030221.21876739
48Chronic myeloid leukemia_Homo sapiens_hsa052201.21028944
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.20953475
50Hedgehog signaling pathway_Homo sapiens_hsa043401.20351422
51Carbon metabolism_Homo sapiens_hsa012001.19414011
52Dorso-ventral axis formation_Homo sapiens_hsa043201.19082165
53Protein export_Homo sapiens_hsa030601.18997953
54Starch and sucrose metabolism_Homo sapiens_hsa005001.18908806
55Adipocytokine signaling pathway_Homo sapiens_hsa049201.15712621
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14588392
57Insulin secretion_Homo sapiens_hsa049111.14225568
58Insulin signaling pathway_Homo sapiens_hsa049101.12998233
59cAMP signaling pathway_Homo sapiens_hsa040241.11851932
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10825058
61Steroid biosynthesis_Homo sapiens_hsa001001.09926653
62Inositol phosphate metabolism_Homo sapiens_hsa005621.06817409
63Calcium signaling pathway_Homo sapiens_hsa040201.06266670
64Type II diabetes mellitus_Homo sapiens_hsa049301.05267255
65Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05190362
66Amoebiasis_Homo sapiens_hsa051461.05075361
67Arginine biosynthesis_Homo sapiens_hsa002201.04925777
68Endometrial cancer_Homo sapiens_hsa052131.03555305
69MicroRNAs in cancer_Homo sapiens_hsa052061.02989291
70Cholinergic synapse_Homo sapiens_hsa047251.02717100
71Tight junction_Homo sapiens_hsa045301.02189030
72Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02138916
73Serotonergic synapse_Homo sapiens_hsa047260.99259484
74Gastric acid secretion_Homo sapiens_hsa049710.97588050
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96856826
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96436621
77Phototransduction_Homo sapiens_hsa047440.96176446
78Salivary secretion_Homo sapiens_hsa049700.95746617
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93506717
80Hippo signaling pathway_Homo sapiens_hsa043900.92482301
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91659024
82beta-Alanine metabolism_Homo sapiens_hsa004100.91586381
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.89211949
84Gap junction_Homo sapiens_hsa045400.88495311
85Complement and coagulation cascades_Homo sapiens_hsa046100.88442809
86Tryptophan metabolism_Homo sapiens_hsa003800.87715826
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87657494
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86206605
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86111067
90Wnt signaling pathway_Homo sapiens_hsa043100.85150954
91Glioma_Homo sapiens_hsa052140.84462466
92Non-homologous end-joining_Homo sapiens_hsa034500.84355589
93Olfactory transduction_Homo sapiens_hsa047400.83769176
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83587760
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82616275
96Pancreatic cancer_Homo sapiens_hsa052120.82222068
97Toxoplasmosis_Homo sapiens_hsa051450.81739393
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81252484
99Bile secretion_Homo sapiens_hsa049760.81185165
100Fat digestion and absorption_Homo sapiens_hsa049750.81150067
101ErbB signaling pathway_Homo sapiens_hsa040120.80999661
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80892669
103Basal cell carcinoma_Homo sapiens_hsa052170.80378679
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79599617
105Biosynthesis of amino acids_Homo sapiens_hsa012300.78636415
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77487831
107FoxO signaling pathway_Homo sapiens_hsa040680.76929259
108TGF-beta signaling pathway_Homo sapiens_hsa043500.76249975
109Protein digestion and absorption_Homo sapiens_hsa049740.75385806
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75286285
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74673474
112Prostate cancer_Homo sapiens_hsa052150.73860328
113VEGF signaling pathway_Homo sapiens_hsa043700.73699858
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.72457913
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72329701
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70377481
117Colorectal cancer_Homo sapiens_hsa052100.68072739
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.67911944
119Melanogenesis_Homo sapiens_hsa049160.67323457
120Non-small cell lung cancer_Homo sapiens_hsa052230.67180073
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66259126
122Estrogen signaling pathway_Homo sapiens_hsa049150.65845508
123ABC transporters_Homo sapiens_hsa020100.65110005
124Pancreatic secretion_Homo sapiens_hsa049720.64803252
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64529569
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63070275
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62477749
128Systemic lupus erythematosus_Homo sapiens_hsa053220.61947720
129Renin-angiotensin system_Homo sapiens_hsa046140.59527752
130Synaptic vesicle cycle_Homo sapiens_hsa047210.59329092
131Viral carcinogenesis_Homo sapiens_hsa052030.58875833
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58610815
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58523664
134Renin secretion_Homo sapiens_hsa049240.57994998
135Ether lipid metabolism_Homo sapiens_hsa005650.57432074
136Bladder cancer_Homo sapiens_hsa052190.57278418
137Caffeine metabolism_Homo sapiens_hsa002320.57225013
138Ras signaling pathway_Homo sapiens_hsa040140.56872284
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56112269
140Linoleic acid metabolism_Homo sapiens_hsa005910.53914452
141HIF-1 signaling pathway_Homo sapiens_hsa040660.53731766
142Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53683328
143Platelet activation_Homo sapiens_hsa046110.53397721
144Renal cell carcinoma_Homo sapiens_hsa052110.52776691
145RNA degradation_Homo sapiens_hsa030180.52560006
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.52472435
147Prolactin signaling pathway_Homo sapiens_hsa049170.51968473
148Maturity onset diabetes of the young_Homo sapiens_hsa049500.51396042
149Melanoma_Homo sapiens_hsa052180.50489701
150Glycerolipid metabolism_Homo sapiens_hsa005610.50479014
151Cardiac muscle contraction_Homo sapiens_hsa042600.50402726
152GnRH signaling pathway_Homo sapiens_hsa049120.49702137
153Oocyte meiosis_Homo sapiens_hsa041140.49694355
154Pentose phosphate pathway_Homo sapiens_hsa000300.49265783
155Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48679376
156HTLV-I infection_Homo sapiens_hsa051660.46951829
157Oxytocin signaling pathway_Homo sapiens_hsa049210.46319533

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