USP48

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA topological change (GO:0006265)5.19454181
2nuclear pore organization (GO:0006999)5.16614460
3nuclear pore complex assembly (GO:0051292)5.10088046
4negative regulation of histone methylation (GO:0031061)4.78878143
5pre-miRNA processing (GO:0031054)4.77404638
6DNA strand elongation involved in DNA replication (GO:0006271)4.33114172
7regulation of histone H3-K4 methylation (GO:0051569)4.26142984
8positive regulation of histone H3-K4 methylation (GO:0051571)4.23407562
9oxygen transport (GO:0015671)4.20024908
10DNA strand elongation (GO:0022616)4.17445952
11DNA synthesis involved in DNA repair (GO:0000731)4.08078942
12telomere maintenance via semi-conservative replication (GO:0032201)3.99073743
13mitotic nuclear envelope disassembly (GO:0007077)3.96860269
14protoporphyrinogen IX metabolic process (GO:0046501)3.95524275
15pore complex assembly (GO:0046931)3.92939482
16regulation of DNA endoreduplication (GO:0032875)3.92239490
17protein localization to kinetochore (GO:0034501)3.90387252
18regulation of histone H3-K27 methylation (GO:0061085)3.89994124
19formation of translation preinitiation complex (GO:0001731)3.87659100
20regulation of translational fidelity (GO:0006450)3.87352990
21positive regulation of histone methylation (GO:0031062)3.82214190
22regulation of gene silencing by RNA (GO:0060966)3.81887164
23regulation of posttranscriptional gene silencing (GO:0060147)3.81887164
24regulation of gene silencing by miRNA (GO:0060964)3.81887164
25nuclear envelope disassembly (GO:0051081)3.80009540
26membrane disassembly (GO:0030397)3.80009540
27meiotic chromosome segregation (GO:0045132)3.79341176
28telomere maintenance via recombination (GO:0000722)3.78130939
29histone H3-K4 trimethylation (GO:0080182)3.76892034
30regulation of histone H3-K9 methylation (GO:0051570)3.76222264
31mitotic recombination (GO:0006312)3.75234237
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.73441685
33regulation of spindle organization (GO:0090224)3.73104292
34histone H4-K12 acetylation (GO:0043983)3.71311333
35gas transport (GO:0015669)3.70250900
36determination of adult lifespan (GO:0008340)3.67797569
37kinetochore organization (GO:0051383)3.66419309
38mitotic sister chromatid cohesion (GO:0007064)3.66257531
39negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.63766703
40positive regulation of chromosome segregation (GO:0051984)3.62421432
41regulation of helicase activity (GO:0051095)3.61578408
42mitotic metaphase plate congression (GO:0007080)3.60096225
43histone H4-K5 acetylation (GO:0043981)3.59589043
44histone H4-K8 acetylation (GO:0043982)3.59589043
45cytoplasmic mRNA processing body assembly (GO:0033962)3.59007187
46sister chromatid segregation (GO:0000819)3.57700883
47mitotic sister chromatid segregation (GO:0000070)3.57035247
48regulation of mitotic spindle organization (GO:0060236)3.54170909
49erythrocyte maturation (GO:0043249)3.53732072
50nucleobase biosynthetic process (GO:0046112)3.51963919
51regulation of telomere maintenance via telomerase (GO:0032210)3.50988447
52histone H2A monoubiquitination (GO:0035518)3.50279085
53regulation of RNA export from nucleus (GO:0046831)3.45490650
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.43229004
55DNA duplex unwinding (GO:0032508)3.41008741
56DNA geometric change (GO:0032392)3.40796412
57peptidyl-lysine trimethylation (GO:0018023)3.37582472
58purine nucleobase biosynthetic process (GO:0009113)3.37032585
59spindle assembly involved in mitosis (GO:0090307)3.35037612
60mitotic chromosome condensation (GO:0007076)3.33838152
61regulation of nuclear cell cycle DNA replication (GO:0033262)3.30316050
62metaphase plate congression (GO:0051310)3.27869506
63negative regulation of erythrocyte differentiation (GO:0045647)3.26094168
64dosage compensation (GO:0007549)3.25451073
65regulation of sister chromatid cohesion (GO:0007063)3.25065669
66mRNA splice site selection (GO:0006376)3.22475499
67histone H4-K16 acetylation (GO:0043984)3.21429537
68positive regulation of mitotic sister chromatid separation (GO:1901970)3.21083105
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.21083105
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.21083105
71histone H2B ubiquitination (GO:0033523)3.20343056
72somatic hypermutation of immunoglobulin genes (GO:0016446)3.17320059
73somatic diversification of immune receptors via somatic mutation (GO:0002566)3.17320059
74ribosome assembly (GO:0042255)3.17232278
75protoporphyrinogen IX biosynthetic process (GO:0006782)3.15853979
76chromosome segregation (GO:0007059)3.15831023
77DNA unwinding involved in DNA replication (GO:0006268)3.15066386
78nucleotide-excision repair, DNA gap filling (GO:0006297)3.14885771
79definitive hemopoiesis (GO:0060216)3.13691123
80protein localization to chromosome, centromeric region (GO:0071459)3.13267643
81interkinetic nuclear migration (GO:0022027)3.12118171
82DNA replication-dependent nucleosome organization (GO:0034723)3.10989560
83DNA replication-dependent nucleosome assembly (GO:0006335)3.10989560
84protein export from nucleus (GO:0006611)3.09580252
85IMP biosynthetic process (GO:0006188)3.07812315
86histone H3-K4 methylation (GO:0051568)3.07370514
87regulation of histone methylation (GO:0031060)3.07361311
88synapsis (GO:0007129)3.07018371
89negative regulation of chromatin modification (GO:1903309)3.06848526
90mitotic G2/M transition checkpoint (GO:0044818)3.06709024
91microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.06604779
92negative regulation of RNA splicing (GO:0033119)3.06344552
93intestinal epithelial cell development (GO:0060576)3.05653567
94negative regulation of histone modification (GO:0031057)3.05285869
95regulation of translational termination (GO:0006449)3.04259596
96negative regulation of mRNA processing (GO:0050686)3.04220187
97negative regulation of translation, ncRNA-mediated (GO:0040033)3.04131116
98regulation of translation, ncRNA-mediated (GO:0045974)3.04131116
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.04131116
100protein K6-linked ubiquitination (GO:0085020)3.03350632
101nuclear envelope organization (GO:0006998)3.03294039
102regulation of chromosome segregation (GO:0051983)3.03249017
103glucocorticoid receptor signaling pathway (GO:0042921)3.03006269
104DNA replication initiation (GO:0006270)3.02649666
105anterior/posterior axis specification, embryo (GO:0008595)3.00666571
106DNA replication checkpoint (GO:0000076)2.99989410
107corticosteroid receptor signaling pathway (GO:0031958)2.97785653
108histone lysine methylation (GO:0034968)2.97554942
109regulation of chromatin binding (GO:0035561)2.97161383
110histone H3-K9 demethylation (GO:0033169)2.96503622
111regulation of centriole replication (GO:0046599)2.92023036
112regulation of centrosome cycle (GO:0046605)2.91813513
113negative regulation of mRNA metabolic process (GO:1903312)2.91408085
114chromatin silencing (GO:0006342)2.91354262
115positive regulation of B cell differentiation (GO:0045579)2.90993643
116histone methylation (GO:0016571)2.87591487
117negative regulation of chromosome segregation (GO:0051985)2.86342651
118heterochromatin organization (GO:0070828)2.86209338
119protein localization to chromosome (GO:0034502)2.86111404
120folic acid-containing compound biosynthetic process (GO:0009396)2.85123083
121regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84004187
122mRNA export from nucleus (GO:0006406)2.83997450
123chromosome condensation (GO:0030261)2.83717901
124negative regulation of DNA repair (GO:0045738)2.83691146
125mRNA transport (GO:0051028)2.83661952
126spindle checkpoint (GO:0031577)2.83149001
127DNA replication-independent nucleosome assembly (GO:0006336)2.82310066
128DNA replication-independent nucleosome organization (GO:0034724)2.82310066
129regulation of translation in response to stress (GO:0043555)2.81524978
130centriole replication (GO:0007099)2.81377975
131regulation of DNA damage checkpoint (GO:2000001)2.80895864
132mitotic spindle checkpoint (GO:0071174)2.80743977
133peptidyl-lysine dimethylation (GO:0018027)2.80584415
134translesion synthesis (GO:0019985)2.79459213
135nucleosome disassembly (GO:0006337)2.79435697
136protein-DNA complex disassembly (GO:0032986)2.79435697
137negative regulation of chromosome organization (GO:2001251)2.79114408
138nucleic acid transport (GO:0050657)2.78335024
139RNA transport (GO:0050658)2.78335024
140establishment of RNA localization (GO:0051236)2.78335024
141histone H3-K9 methylation (GO:0051567)2.78057743
142response to UV-C (GO:0010225)2.78042507
143ATP-dependent chromatin remodeling (GO:0043044)2.77828517
144spindle assembly checkpoint (GO:0071173)2.77823694
145non-recombinational repair (GO:0000726)2.77772694
146double-strand break repair via nonhomologous end joining (GO:0006303)2.77772694
147kinetochore assembly (GO:0051382)2.76607587
148negative regulation of mitotic sister chromatid separation (GO:2000816)2.76333862
149negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76333862
150negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76333862
151negative regulation of sister chromatid segregation (GO:0033046)2.76333862
152regulation of mitotic sister chromatid separation (GO:0010965)2.75956806
153regulation of mitotic sister chromatid segregation (GO:0033047)2.75956806
154regulation of sister chromatid segregation (GO:0033045)2.75956806
155regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.75934694
156mitotic spindle assembly checkpoint (GO:0007094)2.74893571
157regulation of nucleobase-containing compound transport (GO:0032239)2.74420873
158establishment of chromosome localization (GO:0051303)2.73451787
159monoubiquitinated protein deubiquitination (GO:0035520)2.70726222
160spindle assembly (GO:0051225)2.70474840
161DNA conformation change (GO:0071103)2.69838800
162positive regulation of SMAD protein import into nucleus (GO:0060391)2.69510824
163regulation of telomere maintenance (GO:0032204)2.69298670

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.51607475
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.01126205
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.57225623
4* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.43733103
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.20398895
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.84568549
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.77851109
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75581450
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.66517186
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.40744208
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.40744208
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.40744208
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36373560
14* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.35674541
15NANOG_18555785_ChIP-Seq_MESCs_Mouse2.32314721
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.26523297
17MYC_22102868_ChIP-Seq_BL_Human2.24090897
18GATA1_22025678_ChIP-Seq_K562_Human2.11426287
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.10814684
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07684909
21SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.06790191
22* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.04848706
23CIITA_25753668_ChIP-Seq_RAJI_Human2.01208052
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.99542495
25YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98580057
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88677788
27CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.83516864
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78842265
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75443083
30NCOR1_26117541_ChIP-Seq_K562_Human1.74748055
31AR_21909140_ChIP-Seq_LNCAP_Human1.72390428
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71207894
33* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.70958916
34SCL_19346495_ChIP-Seq_HPC-7_Human1.70947622
35ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.68237411
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.68034390
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66938894
38KDM5A_27292631_Chip-Seq_BREAST_Human1.66496699
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64617045
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.63410928
41* TTF2_22483619_ChIP-Seq_HELA_Human1.56181937
42NANOG_21062744_ChIP-ChIP_HESCs_Human1.55958674
43ELK1_19687146_ChIP-ChIP_HELA_Human1.55501161
44* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.55186543
45TCF3_18692474_ChIP-Seq_MEFs_Mouse1.54872003
46* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.54061307
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53588173
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53530772
49GATA1_19941826_ChIP-Seq_K562_Human1.52295656
50* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.49209178
51* ETS1_20019798_ChIP-Seq_JURKAT_Human1.46925716
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45935767
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.45497266
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43313742
55XRN2_22483619_ChIP-Seq_HELA_Human1.42018677
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42018176
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39172478
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38889791
59* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36330298
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33896646
61POU5F1_16518401_ChIP-PET_MESCs_Mouse1.32393816
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30612422
63* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.30494685
64* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30381036
65DCP1A_22483619_ChIP-Seq_HELA_Human1.30259228
66* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.29483084
67* MYB_26560356_Chip-Seq_TH1_Human1.28128271
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27774302
69* MYB_26560356_Chip-Seq_TH2_Human1.25712035
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.25390080
71VDR_23849224_ChIP-Seq_CD4+_Human1.24616367
72* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24602242
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23155395
74PKCTHETA_26484144_Chip-Seq_BREAST_Human1.23096617
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22122404
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21393473
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20208621
78SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20014902
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19054261
80VDR_21846776_ChIP-Seq_THP-1_Human1.19028471
81* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18111361
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17800875
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17443475
84* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16191530
85ZNF263_19887448_ChIP-Seq_K562_Human1.15998716
86* FOXP3_21729870_ChIP-Seq_TREG_Human1.15619017
87* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.15370489
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15179281
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14720571
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14606020
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14332631
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13948550
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13285110
94* GATA2_19941826_ChIP-Seq_K562_Human1.13213788
95* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.10502876
96* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.10079352
97TFEB_21752829_ChIP-Seq_HELA_Human1.10017613
98* EST1_17652178_ChIP-ChIP_JURKAT_Human1.09730003
99* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09517098
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09210666
101GABP_19822575_ChIP-Seq_HepG2_Human1.08903926
102NANOG_16518401_ChIP-PET_MESCs_Mouse1.08794935
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07847196
104* CHD1_26751641_Chip-Seq_LNCaP_Human1.07043342
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05506802
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05452653
107* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05411282
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05376764
109* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04283166
110CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03696050
111* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02023327
112FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01413601
113* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01122952
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01055246
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00465713
116* KAP1_27257070_Chip-Seq_ESCs_Mouse0.99529851
117* MAF_26560356_Chip-Seq_TH1_Human0.99463484
118SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98917624
119ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98834436
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96836470
121* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96439961
122PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94936275
123* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.93895158
124* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93645604
125PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93549074
126SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93471741
127* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93238240
128* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93218510
129PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93145663
130GATA1_26923725_Chip-Seq_HPCs_Mouse0.92846139
131E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92674492
132* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90169200
133* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90123477
134SPI1_23547873_ChIP-Seq_NB4_Human0.88643315
135STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86858387
136CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86622519
137IRF1_19129219_ChIP-ChIP_H3396_Human0.84041352
138GABP_17652178_ChIP-ChIP_JURKAT_Human0.83322983
139* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81785314
140ETS1_22383799_ChIP-Seq_G1ME_Mouse0.80107724
141BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79683226
142SPI1_23127762_ChIP-Seq_K562_Human0.78789094
143UTX_26944678_Chip-Seq_JUKART_Human0.76616706
144CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75401914
145FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.75361551
146ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.74609516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.08657960
2MP0003111_abnormal_nucleus_morphology4.29512649
3MP0010094_abnormal_chromosome_stability3.78977636
4MP0008057_abnormal_DNA_replication3.70760070
5MP0004957_abnormal_blastocyst_morpholog3.46254130
6MP0003077_abnormal_cell_cycle3.16832764
7MP0000569_abnormal_digit_pigmentation2.97992360
8MP0008058_abnormal_DNA_repair2.71781039
9MP0003123_paternal_imprinting2.60330171
10MP0001730_embryonic_growth_arrest2.44480405
11MP0002009_preneoplasia2.41562249
12MP0003656_abnormal_erythrocyte_physiolo2.38198701
13MP0002653_abnormal_ependyma_morphology2.35651702
14MP0003787_abnormal_imprinting2.31674877
15MP0008877_abnormal_DNA_methylation2.27181541
16MP0010307_abnormal_tumor_latency2.22672208
17MP0000350_abnormal_cell_proliferation2.19130610
18MP0010352_gastrointestinal_tract_polyps2.10999225
19MP0002084_abnormal_developmental_patter2.06691409
20MP0001672_abnormal_embryogenesis/_devel2.02682190
21MP0005380_embryogenesis_phenotype2.02682190
22MP0003121_genomic_imprinting2.00662671
23MP0005076_abnormal_cell_differentiation1.97995677
24MP0004147_increased_porphyrin_level1.97320595
25MP0008995_early_reproductive_senescence1.95141284
26MP0003890_abnormal_embryonic-extraembry1.85831955
27MP0004859_abnormal_synaptic_plasticity1.85465338
28MP0002085_abnormal_embryonic_tissue1.84381083
29MP0001697_abnormal_embryo_size1.80293553
30MP0003984_embryonic_growth_retardation1.78576729
31MP0002086_abnormal_extraembryonic_tissu1.78198390
32MP0002088_abnormal_embryonic_growth/wei1.74519823
33MP0003221_abnormal_cardiomyocyte_apopto1.74306101
34MP0003283_abnormal_digestive_organ1.73599404
35MP0008007_abnormal_cellular_replicative1.69578068
36MP0004197_abnormal_fetal_growth/weight/1.68709322
37MP0002396_abnormal_hematopoietic_system1.68423309
38MP0002080_prenatal_lethality1.65187468
39MP0003119_abnormal_digestive_system1.61436872
40MP0005397_hematopoietic_system_phenotyp1.59590834
41MP0001545_abnormal_hematopoietic_system1.59590834
42MP0008932_abnormal_embryonic_tissue1.59588776
43MP0004264_abnormal_extraembryonic_tissu1.57704875
44MP0000372_irregular_coat_pigmentation1.52480851
45MP0009703_decreased_birth_body1.49159024
46MP0002398_abnormal_bone_marrow1.41257751
47MP0003763_abnormal_thymus_physiology1.38233763
48MP0006072_abnormal_retinal_apoptosis1.37253239
49MP0003786_premature_aging1.36638387
50MP0001293_anophthalmia1.31257893
51MP0009672_abnormal_birth_weight1.29505272
52MP0005451_abnormal_body_composition1.26256908
53MP0006292_abnormal_olfactory_placode1.22956361
54MP0004185_abnormal_adipocyte_glucose1.22426681
55MP0009697_abnormal_copulation1.21073224
56MP0002722_abnormal_immune_system1.19694740
57MP0004885_abnormal_endolymph1.18071318
58MP0000689_abnormal_spleen_morphology1.15706516
59MP0003567_abnormal_fetal_cardiomyocyte1.15355188
60MP0002210_abnormal_sex_determination1.15275879
61MP0004133_heterotaxia1.14562985
62MP0000313_abnormal_cell_death1.13941462
63MP0000015_abnormal_ear_pigmentation1.11616574
64MP0001145_abnormal_male_reproductive1.10890444
65MP0002166_altered_tumor_susceptibility1.09779175
66MP0002095_abnormal_skin_pigmentation1.07213400
67MP0003861_abnormal_nervous_system1.07092724
68MP0005408_hypopigmentation1.03844030
69MP0001849_ear_inflammation1.02711197
70MP0001929_abnormal_gametogenesis0.99232407
71MP0004808_abnormal_hematopoietic_stem0.99173335
72MP0005621_abnormal_cell_physiology0.98815598
73MP0005384_cellular_phenotype0.98702781
74MP0003172_abnormal_lysosome_physiology0.98291303
75MP0003632_abnormal_nervous_system0.97858134
76MP0000371_diluted_coat_color0.97500798
77MP0000428_abnormal_craniofacial_morphol0.95402518
78MP0010234_abnormal_vibrissa_follicle0.94466389
79MP0002429_abnormal_blood_cell0.94386699
80MP0002909_abnormal_adrenal_gland0.93721321
81MP0001661_extended_life_span0.92313437
82MP0000537_abnormal_urethra_morphology0.90768885
83MP0008260_abnormal_autophagy0.90557707
84MP0003718_maternal_effect0.89297782
85MP0003385_abnormal_body_wall0.88660525
86MP0002877_abnormal_melanocyte_morpholog0.88017660
87MP0002019_abnormal_tumor_incidence0.87439025
88MP0000653_abnormal_sex_gland0.86731188
89MP0004145_abnormal_muscle_electrophysio0.84977588
90MP0004134_abnormal_chest_morphology0.82358021
91MP0003698_abnormal_male_reproductive0.79569765
92MP0006035_abnormal_mitochondrial_morpho0.79370461
93MP0000703_abnormal_thymus_morphology0.79079006
94MP0000516_abnormal_urinary_system0.78504875
95MP0005367_renal/urinary_system_phenotyp0.78504875
96MP0003935_abnormal_craniofacial_develop0.77194519
97MP0002152_abnormal_brain_morphology0.76351453
98MP0005075_abnormal_melanosome_morpholog0.75578629
99MP0000490_abnormal_crypts_of0.75228405
100MP0008770_decreased_survivor_rate0.74727765
101MP0004233_abnormal_muscle_weight0.73220115
102MP0000716_abnormal_immune_system0.72551887
103MP0002092_abnormal_eye_morphology0.72463529
104MP0005220_abnormal_exocrine_pancreas0.72165274
105MP0002925_abnormal_cardiovascular_devel0.71760334
106MP0005391_vision/eye_phenotype0.71215191
107MP0000358_abnormal_cell_content/0.70920146
108MP0004084_abnormal_cardiac_muscle0.70856629
109MP0005645_abnormal_hypothalamus_physiol0.70480944
110MP0003566_abnormal_cell_adhesion0.69126157
111MP0003943_abnormal_hepatobiliary_system0.68941412
112MP0003937_abnormal_limbs/digits/tail_de0.68757667
113MP0005253_abnormal_eye_physiology0.68598776
114MP0010630_abnormal_cardiac_muscle0.68592610
115MP0002111_abnormal_tail_morphology0.67372923
116MP0002075_abnormal_coat/hair_pigmentati0.67147606
117MP0005171_absent_coat_pigmentation0.66487356
118MP0001286_abnormal_eye_development0.66385333
119MP0003115_abnormal_respiratory_system0.66312829
120MP0002006_tumorigenesis0.66299738
121MP0003705_abnormal_hypodermis_morpholog0.65946697
122MP0002161_abnormal_fertility/fecundity0.65775578
123MP0003315_abnormal_perineum_morphology0.65522954
124MP0003635_abnormal_synaptic_transmissio0.65517182
125MP0005551_abnormal_eye_electrophysiolog0.63593789
126MP0005187_abnormal_penis_morphology0.61833036
127MP0003699_abnormal_female_reproductive0.61352710
128MP0002269_muscular_atrophy0.61317071
129MP0001800_abnormal_humoral_immune0.60737933
130MP0009278_abnormal_bone_marrow0.60654713
131MP0001348_abnormal_lacrimal_gland0.60588642
132MP0000432_abnormal_head_morphology0.59582231
133MP0005389_reproductive_system_phenotype0.59433067
134MP0000955_abnormal_spinal_cord0.59420536
135MP0000598_abnormal_liver_morphology0.59412405
136MP0003300_gastrointestinal_ulcer0.59318126
137MP0002160_abnormal_reproductive_system0.59017564
138MP0003828_pulmonary_edema0.58612798
139MP0001915_intracranial_hemorrhage0.57490599
140MP0000266_abnormal_heart_morphology0.56376734
141MP0009931_abnormal_skin_appearance0.55891332

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.98476793
2Abnormality of the astrocytes (HP:0100707)3.90957323
3Astrocytoma (HP:0009592)3.90957323
4Acute myeloid leukemia (HP:0004808)3.61227178
5Neoplasm of the oral cavity (HP:0100649)3.50295788
6Medulloblastoma (HP:0002885)3.47201946
7Abnormality of the labia minora (HP:0012880)3.46964535
8Glioma (HP:0009733)3.45954434
9Abnormality of the heme biosynthetic pathway (HP:0010472)3.42433369
10Reticulocytosis (HP:0001923)3.38240738
11Birth length less than 3rd percentile (HP:0003561)3.30458849
12Nephroblastoma (Wilms tumor) (HP:0002667)3.13567225
13Acute lymphatic leukemia (HP:0006721)3.12595606
14Abnormal hemoglobin (HP:0011902)3.07969924
15Abnormality of reticulocytes (HP:0004312)3.06173175
16Cortical dysplasia (HP:0002539)3.03850636
17Volvulus (HP:0002580)3.01666038
18Impulsivity (HP:0100710)2.94023274
19Embryonal renal neoplasm (HP:0011794)2.92230677
20Papillary thyroid carcinoma (HP:0002895)2.84121577
21Anal stenosis (HP:0002025)2.81529828
22Dysmetric saccades (HP:0000641)2.77046811
23Abnormality of DNA repair (HP:0003254)2.75169642
24Overlapping toe (HP:0001845)2.73198984
25Prominent nose (HP:0000448)2.72319407
26Cholecystitis (HP:0001082)2.69320040
27Abnormal gallbladder physiology (HP:0012438)2.69320040
28Abnormality of the fingertips (HP:0001211)2.66785233
29Abnormal hair whorl (HP:0010721)2.65884223
30Polycythemia (HP:0001901)2.65678928
31Ankyloglossia (HP:0010296)2.57712668
32Biliary tract neoplasm (HP:0100574)2.57501265
33Colon cancer (HP:0003003)2.57333724
34Abnormality of the lower motor neuron (HP:0002366)2.55556582
35Shawl scrotum (HP:0000049)2.46954503
36Agnosia (HP:0010524)2.46550096
37Poikilocytosis (HP:0004447)2.45913406
38Osteomalacia (HP:0002749)2.44732188
39Chromsome breakage (HP:0040012)2.40691543
40Rhabdomyosarcoma (HP:0002859)2.40664223
41Viral hepatitis (HP:0006562)2.40332016
42Basal cell carcinoma (HP:0002671)2.38849157
43Reticulocytopenia (HP:0001896)2.38474987
44Spinal muscular atrophy (HP:0007269)2.38392668
45Abnormality of cochlea (HP:0000375)2.35188157
46Neoplasm of striated muscle (HP:0009728)2.33607076
47Absent radius (HP:0003974)2.31633456
48Increased nuchal translucency (HP:0010880)2.31185203
49Patellar aplasia (HP:0006443)2.30972301
50Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30587540
51Abnormality of chromosome stability (HP:0003220)2.30107145
52Breast hypoplasia (HP:0003187)2.29309177
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26159680
54Pallor (HP:0000980)2.23024279
55Duplicated collecting system (HP:0000081)2.22793424
56Truncus arteriosus (HP:0001660)2.22677222
57Sandal gap (HP:0001852)2.22544296
58Panhypogammaglobulinemia (HP:0003139)2.20720983
59Impaired smooth pursuit (HP:0007772)2.18899053
60Cafe-au-lait spot (HP:0000957)2.18626391
61Pseudobulbar signs (HP:0002200)2.18481273
62Heterotopia (HP:0002282)2.16889060
63Insomnia (HP:0100785)2.16194662
64Aplasia involving forearm bones (HP:0009822)2.13977215
65Absent forearm bone (HP:0003953)2.13977215
66Aplasia/Hypoplasia of the patella (HP:0006498)2.13456152
67Malignant gastrointestinal tract tumors (HP:0006749)2.08458021
68Gastrointestinal carcinoma (HP:0002672)2.08458021
69IgA deficiency (HP:0002720)2.08049248
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.06228443
71Neoplasm of the small intestine (HP:0100833)2.04496799
72Short chin (HP:0000331)2.04419236
73Aplasia/Hypoplasia of the thymus (HP:0010515)2.03694442
74Embryonal neoplasm (HP:0002898)1.99890178
75Deep philtrum (HP:0002002)1.99118294
76Supernumerary ribs (HP:0005815)1.96633750
77Abnormality of chromosome segregation (HP:0002916)1.96165985
78Meckel diverticulum (HP:0002245)1.96040158
79Hypoparathyroidism (HP:0000829)1.95319551
80Arteriovenous malformation (HP:0100026)1.94906279
81Truncal obesity (HP:0001956)1.94788305
82Hyperacusis (HP:0010780)1.93945323
83Thyroid carcinoma (HP:0002890)1.93345211
84Long eyelashes (HP:0000527)1.92850803
85Abnormality of ocular smooth pursuit (HP:0000617)1.92749397
86Agammaglobulinemia (HP:0004432)1.92327470
87Abnormal biliary tract morphology (HP:0012440)1.92215233
88Abnormality of the renal collecting system (HP:0004742)1.91283275
89Urethral obstruction (HP:0000796)1.90621071
90Long clavicles (HP:0000890)1.89876693
91Carpal bone hypoplasia (HP:0001498)1.89436088
92Abnormality of the ileum (HP:0001549)1.89075476
93Macroorchidism (HP:0000053)1.88142882
94Bowel incontinence (HP:0002607)1.85878218
95Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.85785500
96Short humerus (HP:0005792)1.85472364
97Supernumerary bones of the axial skeleton (HP:0009144)1.84600639
98Abnormality of the carotid arteries (HP:0005344)1.84597864
99Selective tooth agenesis (HP:0001592)1.84487383
100Pointed chin (HP:0000307)1.84094328
101Myelodysplasia (HP:0002863)1.84024971
102Proximal placement of thumb (HP:0009623)1.83816101
103Abnormality of cells of the erythroid lineage (HP:0012130)1.83786485
104Aplasia/hypoplasia of the humerus (HP:0006507)1.83662779
105Cutis marmorata (HP:0000965)1.83508021
106Oligodactyly (hands) (HP:0001180)1.82918202
107Facial hemangioma (HP:0000329)1.82897257
108Obsessive-compulsive behavior (HP:0000722)1.82430758
109Genetic anticipation (HP:0003743)1.82421870
110Hyperthyroidism (HP:0000836)1.81765619
111Congenital stationary night blindness (HP:0007642)1.79976808
112Intestinal fistula (HP:0100819)1.79678019
113Flat cornea (HP:0007720)1.79015246
114Sparse lateral eyebrow (HP:0005338)1.78190688
115Deviation of the thumb (HP:0009603)1.78058812
116Esophageal atresia (HP:0002032)1.77498047
117Abnormality of oral frenula (HP:0000190)1.76686223
118Ectopic kidney (HP:0000086)1.76681447
119Abnormality of the tricuspid valve (HP:0001702)1.76326525
120Aplasia/Hypoplasia of the sternum (HP:0006714)1.76318591
121Hypertensive crisis (HP:0100735)1.75567050
122Diastasis recti (HP:0001540)1.75261879
123Abnormal number of incisors (HP:0011064)1.75153349
124Attention deficit hyperactivity disorder (HP:0007018)1.74701809
125Acanthocytosis (HP:0001927)1.73879451
126Morphological abnormality of the inner ear (HP:0011390)1.73674846
127Delayed puberty (HP:0000823)1.72826481
128High pitched voice (HP:0001620)1.72301563
129Poikiloderma (HP:0001029)1.72154836
130Amaurosis fugax (HP:0100576)1.71863424
131Low anterior hairline (HP:0000294)1.71087643
132Neoplasm of the pancreas (HP:0002894)1.70388409
133Abnormality of the salivary glands (HP:0010286)1.70380259
134Rib fusion (HP:0000902)1.70273928
135Broad palm (HP:0001169)1.70155567
136Relative macrocephaly (HP:0004482)1.69438129
137Abnormality of the preputium (HP:0100587)1.68155788
138Cerebral hypomyelination (HP:0006808)1.67855564
139Sloping forehead (HP:0000340)1.67826823
140Duodenal stenosis (HP:0100867)1.67021941
141Small intestinal stenosis (HP:0012848)1.67021941
142Annular pancreas (HP:0001734)1.66964868
143Renovascular hypertension (HP:0100817)1.66284014
144Abnormal large intestine physiology (HP:0012700)1.66120733
145Seborrheic dermatitis (HP:0001051)1.65652926
146Supernumerary spleens (HP:0009799)1.64797237
147Recurrent viral infections (HP:0004429)1.64585759
148Colitis (HP:0002583)1.63402583
149Broad thumb (HP:0011304)1.63273682
150Neoplasm of the thyroid gland (HP:0100031)1.62561087
151Abnormality of the antihelix (HP:0009738)1.61940066
152Malignant neoplasm of the central nervous system (HP:0100836)1.61489707
153Aplasia/Hypoplasia of the earlobes (HP:0009906)1.57528780
154Abnormality of homocysteine metabolism (HP:0010919)1.57263504
155Homocystinuria (HP:0002156)1.57263504
156Degeneration of anterior horn cells (HP:0002398)1.57011350
157Abnormality of the anterior horn cell (HP:0006802)1.57011350
158Microtia (HP:0008551)1.56479532
159Bone marrow hypocellularity (HP:0005528)1.56347793
160Hypoplasia of the maxilla (HP:0000327)1.56171395
161Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.55526034
162Short 1st metacarpal (HP:0010034)1.55526034
163Urinary bladder sphincter dysfunction (HP:0002839)1.55280684

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.06305743
2BRD43.52285751
3CDC73.21375122
4NEK13.21199725
5WEE13.15782920
6PNCK3.07886156
7NEK22.94181821
8RIPK42.92796124
9AKT32.84671865
10EIF2AK12.75099431
11TSSK62.52599189
12TTK2.50136169
13EPHA22.39050850
14BUB12.20142527
15ALK1.89414814
16SRPK11.79950606
17EEF2K1.78819489
18BRSK21.76682690
19MAP3K131.75413105
20CAMK1D1.75014200
21LATS11.74141739
22CAMKK21.62064314
23CHEK11.54733756
24PLK11.54276730
25PASK1.52103046
26PLK31.51995610
27ATR1.51917310
28CHEK21.51292596
29CAMK1G1.43915752
30RPS6KB21.43840022
31TNIK1.36780454
32TEC1.33841810
33BMPR21.32751430
34MTOR1.26342811
35TRPM71.25042904
36CDK41.23414743
37BRSK11.23152711
38CDK21.17905143
39STK381.17222522
40PRPF4B1.14186812
41MAP3K91.11932205
42ATM1.10355447
43MAP3K141.09909727
44ACVR1B1.09732157
45CDK191.09058928
46FGFR31.08214604
47CDK71.07416898
48SCYL21.05782020
49CLK11.05386752
50AURKB0.99679176
51CAMKK10.99650413
52MAP3K60.98968406
53PDGFRA0.97066489
54MAP3K20.96278610
55DMPK0.94266493
56BTK0.93179286
57SMG10.90929918
58WNK40.90894621
59CDK10.88551886
60ICK0.88505502
61CSNK1E0.88063901
62NUAK10.87428338
63STK30.87157499
64TYRO30.86954467
65RIPK10.86764358
66MKNK20.86453261
67CDK30.85254004
68EIF2AK30.84186766
69CDK60.80333311
70MAPK100.78721461
71CDC42BPA0.77929487
72MAP2K30.77578848
73MAP3K70.76528367
74PRKCI0.75426219
75MELK0.75179488
76NTRK30.75011492
77CSNK1D0.74496095
78MAP4K10.74476946
79PRKDC0.72923414
80CDK80.71400217
81SIK20.70256599
82DYRK30.69996694
83PAK60.67845604
84MAP3K80.66928938
85PLK40.66359262
86GSK3B0.66335354
87LATS20.64425436
88MAPK140.64102629
89MKNK10.62723814
90JAK20.62156684
91JAK30.61686101
92WNK10.61306691
93MAP3K100.60164092
94SYK0.59009297
95YES10.58656764
96MARK30.58540334
97CCNB10.57773218
98KSR10.57050427
99EPHA40.55670365
100NME10.55501097
101FGFR40.54545570
102PRKD30.53911649
103SGK30.53307612
104STK110.52985016
105SGK10.52943750
106MAP3K40.52369485
107PRKAA10.51810531
108TAOK20.50701538
109RET0.50511165
110MAPK110.49308680
111KSR20.49282693
112CSNK2A20.47785873
113MAPK80.45518950
114CSNK1A1L0.44939949
115PBK0.44642871
116FGFR10.43328651
117AURKA0.42815569
118MAPK10.42122099
119RPS6KA30.39655245
120IRAK40.39632867
121RAF10.38805590
122RPS6KA40.37944185
123PRKD20.37841782
124TAOK10.37504992
125STK40.37369312
126TAF10.37274932
127EIF2AK20.36741851
128AKT10.35999895
129PIM10.34744806
130STK100.34697020
131ZAK0.34604794
132RPS6KB10.32152829
133PINK10.31881109
134PDGFRB0.31851614
135AKT20.31605798
136FGFR20.30324012
137SGK20.30184478
138DAPK10.29945874
139CSNK1G20.29908612
140CDK90.29653294

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07562711
2RNA transport_Homo sapiens_hsa030132.99436700
3Mismatch repair_Homo sapiens_hsa034302.94983847
4DNA replication_Homo sapiens_hsa030302.52975734
5mRNA surveillance pathway_Homo sapiens_hsa030152.48280465
6Spliceosome_Homo sapiens_hsa030402.43060246
7Cell cycle_Homo sapiens_hsa041102.22246784
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15176616
9Fanconi anemia pathway_Homo sapiens_hsa034601.92679934
10B cell receptor signaling pathway_Homo sapiens_hsa046621.89081792
11Non-homologous end-joining_Homo sapiens_hsa034501.88894376
12One carbon pool by folate_Homo sapiens_hsa006701.85055062
13Homologous recombination_Homo sapiens_hsa034401.82846936
14mTOR signaling pathway_Homo sapiens_hsa041501.82248379
15Acute myeloid leukemia_Homo sapiens_hsa052211.79982492
16Pancreatic cancer_Homo sapiens_hsa052121.78611690
17Oocyte meiosis_Homo sapiens_hsa041141.75323718
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.69229294
19Base excision repair_Homo sapiens_hsa034101.67642030
20Nucleotide excision repair_Homo sapiens_hsa034201.67456986
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.66601417
22RNA polymerase_Homo sapiens_hsa030201.58494952
23Vitamin B6 metabolism_Homo sapiens_hsa007501.49825251
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47375436
25RNA degradation_Homo sapiens_hsa030181.38490327
26Lysine degradation_Homo sapiens_hsa003101.26515993
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26362428
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21811338
29Type II diabetes mellitus_Homo sapiens_hsa049301.18243552
30Basal transcription factors_Homo sapiens_hsa030221.13449172
31Olfactory transduction_Homo sapiens_hsa047401.13032311
32Regulation of autophagy_Homo sapiens_hsa041401.12790864
33Long-term potentiation_Homo sapiens_hsa047201.11764192
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11175507
35Inositol phosphate metabolism_Homo sapiens_hsa005621.08085519
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02435476
37Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01647692
38p53 signaling pathway_Homo sapiens_hsa041151.00790742
39Endometrial cancer_Homo sapiens_hsa052131.00126556
40Colorectal cancer_Homo sapiens_hsa052100.99447781
41Hepatitis B_Homo sapiens_hsa051610.97577104
42Circadian rhythm_Homo sapiens_hsa047100.92088243
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91778885
44MicroRNAs in cancer_Homo sapiens_hsa052060.91034672
45VEGF signaling pathway_Homo sapiens_hsa043700.85378002
46Measles_Homo sapiens_hsa051620.84858999
47Primary immunodeficiency_Homo sapiens_hsa053400.84792082
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84359416
49Epstein-Barr virus infection_Homo sapiens_hsa051690.83950915
50Prolactin signaling pathway_Homo sapiens_hsa049170.83836432
51Hippo signaling pathway_Homo sapiens_hsa043900.82863453
52Biosynthesis of amino acids_Homo sapiens_hsa012300.79897767
53Insulin secretion_Homo sapiens_hsa049110.78831905
54Glutamatergic synapse_Homo sapiens_hsa047240.78339896
55Pyrimidine metabolism_Homo sapiens_hsa002400.77397000
56Viral carcinogenesis_Homo sapiens_hsa052030.76975619
57Amphetamine addiction_Homo sapiens_hsa050310.76864644
58T cell receptor signaling pathway_Homo sapiens_hsa046600.75616349
59Non-small cell lung cancer_Homo sapiens_hsa052230.75288284
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.75112842
61HTLV-I infection_Homo sapiens_hsa051660.73664836
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73336996
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72892634
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72092248
65Estrogen signaling pathway_Homo sapiens_hsa049150.70470469
66Apoptosis_Homo sapiens_hsa042100.69905296
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.69657830
68Phototransduction_Homo sapiens_hsa047440.69134893
69Purine metabolism_Homo sapiens_hsa002300.68337690
70FoxO signaling pathway_Homo sapiens_hsa040680.67331604
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66590880
72Melanoma_Homo sapiens_hsa052180.66230221
73Choline metabolism in cancer_Homo sapiens_hsa052310.65934133
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65394061
75HIF-1 signaling pathway_Homo sapiens_hsa040660.64778436
76Nicotine addiction_Homo sapiens_hsa050330.64218249
77Antigen processing and presentation_Homo sapiens_hsa046120.63846378
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63802353
79Platelet activation_Homo sapiens_hsa046110.63673483
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63279892
81Adherens junction_Homo sapiens_hsa045200.62880770
82AMPK signaling pathway_Homo sapiens_hsa041520.62727276
83Dopaminergic synapse_Homo sapiens_hsa047280.62429515
84Wnt signaling pathway_Homo sapiens_hsa043100.61971353
85Notch signaling pathway_Homo sapiens_hsa043300.61225398
86Chronic myeloid leukemia_Homo sapiens_hsa052200.61215051
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.60675043
88Glioma_Homo sapiens_hsa052140.60545525
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60191221
90Ribosome_Homo sapiens_hsa030100.59770655
91Circadian entrainment_Homo sapiens_hsa047130.59265640
92Selenocompound metabolism_Homo sapiens_hsa004500.59259617
93Synaptic vesicle cycle_Homo sapiens_hsa047210.58987925
94Morphine addiction_Homo sapiens_hsa050320.58933089
95Fructose and mannose metabolism_Homo sapiens_hsa000510.58288660
96Carbon metabolism_Homo sapiens_hsa012000.56199563
97Hedgehog signaling pathway_Homo sapiens_hsa043400.55858254
98Insulin signaling pathway_Homo sapiens_hsa049100.55625032
99Prostate cancer_Homo sapiens_hsa052150.55464717
100ErbB signaling pathway_Homo sapiens_hsa040120.55358505
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.54734571
102GABAergic synapse_Homo sapiens_hsa047270.54384454
103Oxytocin signaling pathway_Homo sapiens_hsa049210.54046757
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53933524
105Tight junction_Homo sapiens_hsa045300.53542602
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.52260760
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51665263
108Dorso-ventral axis formation_Homo sapiens_hsa043200.49575813
109Basal cell carcinoma_Homo sapiens_hsa052170.49560216
110Influenza A_Homo sapiens_hsa051640.49079462
111Alcoholism_Homo sapiens_hsa050340.48902981
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48203020
113MAPK signaling pathway_Homo sapiens_hsa040100.47581937
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47012260
115Small cell lung cancer_Homo sapiens_hsa052220.46839381
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46732640
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.45537615
118Glucagon signaling pathway_Homo sapiens_hsa049220.45169168
119Thyroid cancer_Homo sapiens_hsa052160.45053240
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44275363
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43634756
122Renal cell carcinoma_Homo sapiens_hsa052110.41976790
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41838326
124GnRH signaling pathway_Homo sapiens_hsa049120.41759039
125Pathways in cancer_Homo sapiens_hsa052000.41540245
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.40968056
127Herpes simplex infection_Homo sapiens_hsa051680.40028986
128Gap junction_Homo sapiens_hsa045400.39779865
129Bladder cancer_Homo sapiens_hsa052190.35948085
130Hepatitis C_Homo sapiens_hsa051600.34735995
131NF-kappa B signaling pathway_Homo sapiens_hsa040640.33554489
132Pyruvate metabolism_Homo sapiens_hsa006200.30310215
133Shigellosis_Homo sapiens_hsa051310.29436911
134Systemic lupus erythematosus_Homo sapiens_hsa053220.25803778

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