USP49

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.10067832
2pre-miRNA processing (GO:0031054)4.65790965
3nuclear pore complex assembly (GO:0051292)4.12963157
4presynaptic membrane assembly (GO:0097105)4.03381581
5behavioral response to nicotine (GO:0035095)3.99033191
6nuclear pore organization (GO:0006999)3.92629711
7regulation of RNA export from nucleus (GO:0046831)3.84052998
8pyrimidine nucleobase catabolic process (GO:0006208)3.83915619
9regulation of sister chromatid cohesion (GO:0007063)3.73906682
10regulation of gene silencing by RNA (GO:0060966)3.72338271
11regulation of posttranscriptional gene silencing (GO:0060147)3.72338271
12regulation of gene silencing by miRNA (GO:0060964)3.72338271
13sister chromatid segregation (GO:0000819)3.70041599
14mitotic chromosome condensation (GO:0007076)3.60524927
15negative regulation of histone methylation (GO:0031061)3.47381005
16presynaptic membrane organization (GO:0097090)3.46014995
17paraxial mesoderm development (GO:0048339)3.42923958
18response to pheromone (GO:0019236)3.30576721
19layer formation in cerebral cortex (GO:0021819)3.27849445
20cytoplasmic mRNA processing body assembly (GO:0033962)3.22079687
21negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.19503947
22mitotic sister chromatid segregation (GO:0000070)3.19454124
23peptidyl-lysine dimethylation (GO:0018027)3.18520080
24DNA unwinding involved in DNA replication (GO:0006268)3.18282213
25postsynaptic membrane organization (GO:0001941)3.13478523
26heterochromatin organization (GO:0070828)3.09652101
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.08784502
28positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.08043221
29positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.08043221
30positive regulation of mitotic sister chromatid separation (GO:1901970)3.08043221
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.07561938
32protein localization to kinetochore (GO:0034501)3.05522004
33stress granule assembly (GO:0034063)3.04653439
34regulation of nucleobase-containing compound transport (GO:0032239)3.04591671
35negative regulation of organelle assembly (GO:1902116)3.04434493
36nucleobase catabolic process (GO:0046113)3.04027152
37dosage compensation (GO:0007549)3.03416957
38hippo signaling (GO:0035329)3.00786190
39cell migration in hindbrain (GO:0021535)2.96673590
40protein localization to chromosome, centromeric region (GO:0071459)2.94381631
41neural tube formation (GO:0001841)2.93830246
42neuron cell-cell adhesion (GO:0007158)2.93646029
43NLS-bearing protein import into nucleus (GO:0006607)2.92447830
44RNA stabilization (GO:0043489)2.92195238
45mRNA stabilization (GO:0048255)2.92195238
46regulation of nuclear cell cycle DNA replication (GO:0033262)2.92017637
47meiotic chromosome segregation (GO:0045132)2.91674573
48positive regulation of oligodendrocyte differentiation (GO:0048714)2.90227132
49gene silencing by RNA (GO:0031047)2.88672376
50hindbrain development (GO:0030902)2.87628816
51regulation of histone H3-K9 methylation (GO:0051570)2.87430323
52negative regulation of mRNA processing (GO:0050686)2.86067609
53chromatin assembly (GO:0031497)2.85628475
54regulation of telomere maintenance (GO:0032204)2.85197753
55protein-DNA complex disassembly (GO:0032986)2.84955763
56nucleosome disassembly (GO:0006337)2.84955763
57cell proliferation in forebrain (GO:0021846)2.84777685
58gene silencing (GO:0016458)2.83695458
59somite development (GO:0061053)2.82136827
60DNA replication-dependent nucleosome organization (GO:0034723)2.81404586
61DNA replication-dependent nucleosome assembly (GO:0006335)2.81404586
62detection of light stimulus involved in visual perception (GO:0050908)2.81280287
63detection of light stimulus involved in sensory perception (GO:0050962)2.81280287
64resolution of meiotic recombination intermediates (GO:0000712)2.81066815
65intracellular estrogen receptor signaling pathway (GO:0030520)2.79514293
66glucocorticoid receptor signaling pathway (GO:0042921)2.79456981
67establishment of nucleus localization (GO:0040023)2.79169999
68nonmotile primary cilium assembly (GO:0035058)2.78774791
69regulation of DNA damage checkpoint (GO:2000001)2.77987335
70regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.77377930
71pore complex assembly (GO:0046931)2.76997599
72monoubiquitinated protein deubiquitination (GO:0035520)2.76271782
73histone H2A monoubiquitination (GO:0035518)2.76175557
74positive regulation of chromosome segregation (GO:0051984)2.75906811
75negative regulation of RNA splicing (GO:0033119)2.75800374
76mitotic nuclear envelope disassembly (GO:0007077)2.74930119
77regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.73709187
78kinetochore organization (GO:0051383)2.71796737
79kidney morphogenesis (GO:0060993)2.71374524
80regulation of chromatin binding (GO:0035561)2.71228155
81chromosome condensation (GO:0030261)2.71063135
82negative regulation of catenin import into nucleus (GO:0035414)2.70232152
83histone H4-K16 acetylation (GO:0043984)2.69773272
84membrane disassembly (GO:0030397)2.69579157
85nuclear envelope disassembly (GO:0051081)2.69579157
86spinal cord development (GO:0021510)2.69546240
87negative regulation of mRNA metabolic process (GO:1903312)2.69421035
88regulation of centriole replication (GO:0046599)2.69166867
89negative regulation of DNA-dependent DNA replication (GO:2000104)2.66978046
90forebrain neuron differentiation (GO:0021879)2.64802496
91double-strand break repair via homologous recombination (GO:0000724)2.62283775
92recombinational repair (GO:0000725)2.62111664
93limb bud formation (GO:0060174)2.61398989
94histone H3-K9 methylation (GO:0051567)2.61007195
95gastrulation with mouth forming second (GO:0001702)2.60468636
96spinal cord motor neuron differentiation (GO:0021522)2.60070485
97regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.59519064
98DNA duplex unwinding (GO:0032508)2.59460558
99DNA geometric change (GO:0032392)2.59430836
100chromatin assembly or disassembly (GO:0006333)2.59408593
101atrial cardiac muscle cell action potential (GO:0086014)2.59066434
102mRNA splice site selection (GO:0006376)2.58476570
103neuronal stem cell maintenance (GO:0097150)2.57845720
104head development (GO:0060322)2.57495815
105central nervous system neuron axonogenesis (GO:0021955)2.56944229
106reciprocal meiotic recombination (GO:0007131)2.56890762
107reciprocal DNA recombination (GO:0035825)2.56890762
108histone H4-K5 acetylation (GO:0043981)2.56349348
109histone H4-K8 acetylation (GO:0043982)2.56349348
110microtubule anchoring (GO:0034453)2.56251510
111retinal ganglion cell axon guidance (GO:0031290)2.55092624
112histone H3-K4 methylation (GO:0051568)2.53946679
113sister chromatid cohesion (GO:0007062)2.53847719
114replication fork processing (GO:0031297)2.53725209
115centriole replication (GO:0007099)2.53588335
116detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.53537122
117histone H3-K4 trimethylation (GO:0080182)2.53018549
118protein localization to chromosome (GO:0034502)2.52051509
119negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.52009754
120negative regulation of translation, ncRNA-mediated (GO:0040033)2.52009754
121regulation of translation, ncRNA-mediated (GO:0045974)2.52009754
122somatic hypermutation of immunoglobulin genes (GO:0016446)2.51722698
123somatic diversification of immune receptors via somatic mutation (GO:0002566)2.51722698
124lateral sprouting from an epithelium (GO:0060601)2.51467751
125gamma-aminobutyric acid transport (GO:0015812)2.51026785
126planar cell polarity pathway involved in neural tube closure (GO:0090179)2.50849644
127microtubule polymerization or depolymerization (GO:0031109)2.49201578
128translesion synthesis (GO:0019985)2.49132362
129G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48585632
130regulation of chromosome segregation (GO:0051983)2.48553010
131regulation of timing of cell differentiation (GO:0048505)2.47473993
132olfactory bulb development (GO:0021772)2.47374267
133regulation of DNA endoreduplication (GO:0032875)2.46717262
134protein K11-linked deubiquitination (GO:0035871)2.46525013
135chromatin silencing (GO:0006342)2.45802336
136ncRNA catabolic process (GO:0034661)2.45716594
137histone lysine methylation (GO:0034968)2.45702709
138appendage development (GO:0048736)2.45345959
139limb development (GO:0060173)2.45345959
140microtubule depolymerization (GO:0007019)2.44979651
141cilium organization (GO:0044782)2.44750210
142regulation of development, heterochronic (GO:0040034)2.43665080
143regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43365121
144negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43193886
145regulation of collateral sprouting (GO:0048670)2.42048625
146spliceosomal tri-snRNP complex assembly (GO:0000244)2.41925835
147body morphogenesis (GO:0010171)2.41670846
148DNA replication checkpoint (GO:0000076)2.41609464
149DNA double-strand break processing (GO:0000729)2.41529284
150kinetochore assembly (GO:0051382)2.41456134
151DNA packaging (GO:0006323)2.41321715
152cilium assembly (GO:0042384)2.41190186
153protein polyglutamylation (GO:0018095)2.39826171
154dorsal/ventral axis specification (GO:0009950)2.39823384
155regulation of mRNA stability (GO:0043488)2.39778571
156negative regulation of gene expression, epigenetic (GO:0045814)2.39524307
157embryonic body morphogenesis (GO:0010172)2.39116912
158corticosteroid receptor signaling pathway (GO:0031958)2.39102538
159establishment of spindle localization (GO:0051293)2.38183029
160transmission of nerve impulse (GO:0019226)2.37580404
161cornea development in camera-type eye (GO:0061303)2.37541054
162regulation of centrosome cycle (GO:0046605)2.37344039
163intraciliary transport (GO:0042073)2.37221275
164histone methylation (GO:0016571)2.37151134
165nucleus localization (GO:0051647)2.37098503
166regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37081883
167central nervous system projection neuron axonogenesis (GO:0021952)2.36800015
168histone H4-K12 acetylation (GO:0043983)2.36775632
169epithelial cilium movement (GO:0003351)2.36152353
170membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.35488100
171regulation of sarcomere organization (GO:0060297)2.34668216
172microtubule organizing center organization (GO:0031023)2.33239090
173cell differentiation in spinal cord (GO:0021515)2.32900196
174otic vesicle formation (GO:0030916)2.32796921
175regulation of cilium movement (GO:0003352)2.32583877
176negative regulation of neurotransmitter transport (GO:0051589)2.32065394
177sympathetic nervous system development (GO:0048485)2.31975711
178fucose catabolic process (GO:0019317)2.30511647
179L-fucose metabolic process (GO:0042354)2.30511647
180L-fucose catabolic process (GO:0042355)2.30511647
181interkinetic nuclear migration (GO:0022027)2.30211895
182kynurenine metabolic process (GO:0070189)2.29468275
183synapsis (GO:0007129)2.28737408
184protein localization to synapse (GO:0035418)2.28675426
185peptidyl-lysine methylation (GO:0018022)2.28327690
186cellular response to sterol (GO:0036315)2.28304019
187indolalkylamine metabolic process (GO:0006586)2.27418536
188centrosome organization (GO:0051297)2.26746895
189cilium or flagellum-dependent cell motility (GO:0001539)2.26697548
190neuron recognition (GO:0008038)2.26597593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.46510891
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.01099980
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.21604615
4GBX2_23144817_ChIP-Seq_PC3_Human3.13277747
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.10912804
6IGF1R_20145208_ChIP-Seq_DFB_Human3.05446588
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.89669992
8* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79812350
9EZH2_22144423_ChIP-Seq_EOC_Human2.71968414
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.68339250
11FUS_26573619_Chip-Seq_HEK293_Human2.61242456
12VDR_22108803_ChIP-Seq_LS180_Human2.49172026
13EWS_26573619_Chip-Seq_HEK293_Human2.45666413
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44514874
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43250162
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40742645
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.37741585
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.37306118
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31637175
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28065109
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27272440
22TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.26353432
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23491156
24SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.22511783
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.20566786
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.20149403
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16743192
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.16252887
29MYC_22102868_ChIP-Seq_BL_Human2.14136774
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07077892
31CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05377506
32TAF15_26573619_Chip-Seq_HEK293_Human2.04273222
33P300_19829295_ChIP-Seq_ESCs_Human2.00427987
34ZFP281_27345836_Chip-Seq_ESCs_Mouse1.97871529
35PKCTHETA_26484144_Chip-Seq_BREAST_Human1.93558104
36IRF1_19129219_ChIP-ChIP_H3396_Human1.92714759
37DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.90396931
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.83982190
39* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.82398071
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.80191590
41* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.77465922
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73953614
43FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.70367107
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68046507
45KDM2B_26808549_Chip-Seq_DND41_Human1.67279713
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.66214239
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65902769
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.65902769
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63958750
50AR_21572438_ChIP-Seq_LNCaP_Human1.62504913
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60759484
52RNF2_27304074_Chip-Seq_NSC_Mouse1.60484448
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59354998
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58328491
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57800946
56REST_21632747_ChIP-Seq_MESCs_Mouse1.57700758
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56427571
58* ER_23166858_ChIP-Seq_MCF-7_Human1.56086529
59KDM2B_26808549_Chip-Seq_K562_Human1.55696092
60ZNF263_19887448_ChIP-Seq_K562_Human1.55623539
61AR_21909140_ChIP-Seq_LNCAP_Human1.54923958
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54006188
63* NANOG_21062744_ChIP-ChIP_HESCs_Human1.53156153
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52937542
65* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.51886798
66* STAT3_23295773_ChIP-Seq_U87_Human1.51190910
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.51062678
68* SMAD4_21799915_ChIP-Seq_A2780_Human1.50844749
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50695653
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49407212
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.48933685
72* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.45666918
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45285996
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44448988
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.44148357
76* TCF7_22412390_ChIP-Seq_EML_Mouse1.42981508
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41025702
78CBP_20019798_ChIP-Seq_JUKART_Human1.41025702
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.40582441
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39817425
81TCF4_23295773_ChIP-Seq_U87_Human1.39620448
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39445684
83CIITA_25753668_ChIP-Seq_RAJI_Human1.37179414
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36123493
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34129058
86MYC_18940864_ChIP-ChIP_HL60_Human1.33979017
87GATA1_26923725_Chip-Seq_HPCs_Mouse1.33923988
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33846593
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.33791126
90AR_25329375_ChIP-Seq_VCAP_Human1.32979811
91SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32888008
92SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30848637
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.30696434
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.30649443
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30197760
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28652848
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28320251
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27797428
99EZH2_27304074_Chip-Seq_ESCs_Mouse1.24914968
100TP53_22573176_ChIP-Seq_HFKS_Human1.22173721
101* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.21896042
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21100744
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20046023
104EST1_17652178_ChIP-ChIP_JURKAT_Human1.19192895
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18315691
106ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17493998
107BCAT_22108803_ChIP-Seq_LS180_Human1.17078664
108* RUNX2_22187159_ChIP-Seq_PCA_Human1.16466219
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16308132
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16045450
111TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.15378697
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14061507
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12982135
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12678950
115TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11911617
116JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11368541
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11234192
118POU5F1_16518401_ChIP-PET_MESCs_Mouse1.10825713
119ELK1_19687146_ChIP-ChIP_HELA_Human1.10587128
120PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10049261
121TCF4_22108803_ChIP-Seq_LS180_Human1.09795616
122RING1B_27294783_Chip-Seq_NPCs_Mouse1.08935919
123REST_18959480_ChIP-ChIP_MESCs_Mouse1.08820342
124RARB_27405468_Chip-Seq_BRAIN_Mouse1.08178353
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07017237
126CHD1_26751641_Chip-Seq_LNCaP_Human1.06530601
127TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06465078
128TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04370702
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03258022
130* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03002836
131FLI1_21867929_ChIP-Seq_TH2_Mouse1.01901236
132CREB1_26743006_Chip-Seq_LNCaP_Human1.01609822
133* SOX9_26525672_Chip-Seq_HEART_Mouse1.01595130
134KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01019246
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00832126
136MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99579506
137* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99246347
138NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98550589
139STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97220592
140NANOG_19829295_ChIP-Seq_ESCs_Human0.97097548
141SOX2_19829295_ChIP-Seq_ESCs_Human0.97097548
142* SOX2_21211035_ChIP-Seq_LN229_Gbm0.96610015
143TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95737377
144SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95692160
145KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95163019
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95123227
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94138506
148NANOG_18555785_Chip-Seq_ESCs_Mouse0.93818246
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93646261
150* PRDM14_20953172_ChIP-Seq_ESCs_Human0.93566206
151CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93090772
152P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92433205
153CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92218012
154KDM5A_27292631_Chip-Seq_BREAST_Human0.92050859
155GABP_17652178_ChIP-ChIP_JURKAT_Human0.91135541
156NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90781741
157NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90454177
158CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90316140
159KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.89738675
160KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89116426
161PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88587246
162YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87586216
163* SOX2_16153702_ChIP-ChIP_HESCs_Human0.87164704
164AR_19668381_ChIP-Seq_PC3_Human0.86980342
165MYC_19079543_ChIP-ChIP_MESCs_Mouse0.86647335
166YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84492455
167WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84323337
168KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82576662
169WDR5_24793694_ChIP-Seq_LNCAP_Human0.82349718
170RUNX1_26923725_Chip-Seq_HPCs_Mouse0.82343984
171RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82319998
172VDR_21846776_ChIP-Seq_THP-1_Human0.81351146
173CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.81210387
174PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.80929158
175DROSHA_22980978_ChIP-Seq_HELA_Human0.80875465
176SOX2_18692474_ChIP-Seq_MESCs_Mouse0.80853293
177NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80170068
178OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79664666
179ZNF274_21170338_ChIP-Seq_K562_Hela0.79564075
180RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.79043548
181SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.78547994
182TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.77535375

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.44243938
2MP0003136_yellow_coat_color2.78101098
3MP0002653_abnormal_ependyma_morphology2.75132932
4MP0000569_abnormal_digit_pigmentation2.72109701
5MP0003111_abnormal_nucleus_morphology2.53029350
6MP0005076_abnormal_cell_differentiation2.51940120
7MP0000537_abnormal_urethra_morphology2.51759518
8MP0003787_abnormal_imprinting2.41453254
9MP0003121_genomic_imprinting2.34342846
10MP0010094_abnormal_chromosome_stability2.31178929
11MP0010030_abnormal_orbit_morphology2.30711975
12MP0003890_abnormal_embryonic-extraembry2.26978760
13MP0008877_abnormal_DNA_methylation2.23976828
14MP0003880_abnormal_central_pattern2.14826418
15MP0002102_abnormal_ear_morphology2.08747885
16MP0009053_abnormal_anal_canal2.08668948
17MP0003123_paternal_imprinting2.01336221
18MP0003705_abnormal_hypodermis_morpholog1.97018503
19MP0002084_abnormal_developmental_patter1.88180986
20MP0010352_gastrointestinal_tract_polyps1.86054440
21MP0001529_abnormal_vocalization1.85708022
22MP0005551_abnormal_eye_electrophysiolog1.85666698
23MP0005187_abnormal_penis_morphology1.81210506
24MP0003119_abnormal_digestive_system1.78416589
25MP0002638_abnormal_pupillary_reflex1.76968987
26MP0010234_abnormal_vibrissa_follicle1.76357464
27MP0003077_abnormal_cell_cycle1.74107447
28MP0008057_abnormal_DNA_replication1.70283961
29MP0002085_abnormal_embryonic_tissue1.68678834
30MP0010307_abnormal_tumor_latency1.64753869
31MP0002735_abnormal_chemical_nociception1.62807989
32MP0001968_abnormal_touch/_nociception1.61466370
33MP0001730_embryonic_growth_arrest1.60585901
34MP0003937_abnormal_limbs/digits/tail_de1.59271972
35MP0003861_abnormal_nervous_system1.58695069
36MP0009046_muscle_twitch1.57325707
37MP0004142_abnormal_muscle_tone1.56386129
38MP0004197_abnormal_fetal_growth/weight/1.55147752
39MP0000350_abnormal_cell_proliferation1.54323383
40MP0001672_abnormal_embryogenesis/_devel1.54158243
41MP0005380_embryogenesis_phenotype1.54158243
42MP0005253_abnormal_eye_physiology1.51456176
43MP0004859_abnormal_synaptic_plasticity1.50719515
44MP0002822_catalepsy1.49540449
45MP0004885_abnormal_endolymph1.49273451
46MP0000778_abnormal_nervous_system1.49087696
47MP0003283_abnormal_digestive_organ1.48453886
48MP0003935_abnormal_craniofacial_develop1.47570641
49MP0004233_abnormal_muscle_weight1.46863466
50MP0003635_abnormal_synaptic_transmissio1.45983687
51MP0006072_abnormal_retinal_apoptosis1.45895974
52MP0001697_abnormal_embryo_size1.45258110
53MP0000428_abnormal_craniofacial_morphol1.45132826
54MP0009745_abnormal_behavioral_response1.45062403
55MP0001486_abnormal_startle_reflex1.42655733
56MP0002088_abnormal_embryonic_growth/wei1.40821516
57MP0001293_anophthalmia1.40112016
58MP0003984_embryonic_growth_retardation1.39836237
59MP0003122_maternal_imprinting1.38891555
60MP0004957_abnormal_blastocyst_morpholog1.38184902
61MP0003567_abnormal_fetal_cardiomyocyte1.36976634
62MP0001849_ear_inflammation1.36704586
63MP0006276_abnormal_autonomic_nervous1.35901301
64MP0000733_abnormal_muscle_development1.35766038
65MP0001984_abnormal_olfaction1.34143974
66MP0002272_abnormal_nervous_system1.33978227
67MP0002736_abnormal_nociception_after1.33942981
68MP0003755_abnormal_palate_morphology1.33710871
69MP0009703_decreased_birth_body1.33154450
70MP0002751_abnormal_autonomic_nervous1.33003962
71MP0001485_abnormal_pinna_reflex1.32650359
72MP0002086_abnormal_extraembryonic_tissu1.32290404
73MP0003385_abnormal_body_wall1.32015914
74MP0002063_abnormal_learning/memory/cond1.31050811
75MP0003115_abnormal_respiratory_system1.30901204
76MP0002557_abnormal_social/conspecific_i1.29973301
77MP0003693_abnormal_embryo_hatching1.27483882
78MP0001986_abnormal_taste_sensitivity1.26495854
79MP0002572_abnormal_emotion/affect_behav1.25366728
80MP0005248_abnormal_Harderian_gland1.22064116
81MP0004133_heterotaxia1.19590425
82MP0005174_abnormal_tail_pigmentation1.18633699
83MP0005646_abnormal_pituitary_gland1.17298813
84MP0005394_taste/olfaction_phenotype1.16095905
85MP0005499_abnormal_olfactory_system1.16095905
86MP0002064_seizures1.14796124
87MP0002116_abnormal_craniofacial_bone1.14114485
88MP0002160_abnormal_reproductive_system1.14041537
89MP0008995_early_reproductive_senescence1.13825579
90MP0004185_abnormal_adipocyte_glucose1.13230025
91MP0008961_abnormal_basal_metabolism1.13171721
92MP0009672_abnormal_birth_weight1.12973989
93MP0002734_abnormal_mechanical_nocicepti1.12479821
94MP0002932_abnormal_joint_morphology1.12385529
95MP0002752_abnormal_somatic_nervous1.12226032
96MP0005386_behavior/neurological_phenoty1.11579299
97MP0004924_abnormal_behavior1.11579299
98MP0003942_abnormal_urinary_system1.11341675
99MP0002080_prenatal_lethality1.11140797
100MP0002092_abnormal_eye_morphology1.10982181
101MP0008789_abnormal_olfactory_epithelium1.10049241
102MP0004742_abnormal_vestibular_system1.09910184
103MP0000534_abnormal_ureter_morphology1.09722196
104MP0005645_abnormal_hypothalamus_physiol1.09623549
105MP0000631_abnormal_neuroendocrine_gland1.08735421
106MP0000432_abnormal_head_morphology1.08406054
107MP0009278_abnormal_bone_marrow1.08397572
108MP0008058_abnormal_DNA_repair1.08324373
109MP0001299_abnormal_eye_distance/1.07628828
110MP0002882_abnormal_neuron_morphology1.07494360
111MP0005195_abnormal_posterior_eye1.05161655
112MP0002152_abnormal_brain_morphology1.04173107
113MP0002210_abnormal_sex_determination1.03689410
114MP0002067_abnormal_sensory_capabilities1.03634822
115MP0003646_muscle_fatigue1.03375350
116MP0002938_white_spotting1.02346963
117MP0003315_abnormal_perineum_morphology1.01322841
118MP0002837_dystrophic_cardiac_calcinosis1.01318314
119MP0002233_abnormal_nose_morphology1.00605776
120MP0009250_abnormal_appendicular_skeleto0.99758487
121MP0000566_synostosis0.98228671
122MP0002081_perinatal_lethality0.97382867
123MP0000049_abnormal_middle_ear0.97207777
124MP0001970_abnormal_pain_threshold0.96945734
125MP0002282_abnormal_trachea_morphology0.95773658
126MP0005171_absent_coat_pigmentation0.95443952
127MP0002733_abnormal_thermal_nociception0.95438964
128MP0002697_abnormal_eye_size0.94892714
129MP0008932_abnormal_embryonic_tissue0.94694793
130MP0001929_abnormal_gametogenesis0.94313240
131MP0001145_abnormal_male_reproductive0.94050452
132MP0000462_abnormal_digestive_system0.94010154
133MP0001286_abnormal_eye_development0.93837568
134MP0002114_abnormal_axial_skeleton0.93680062
135MP0005377_hearing/vestibular/ear_phenot0.93523806
136MP0003878_abnormal_ear_physiology0.93523806
137MP0005423_abnormal_somatic_nervous0.93294500
138MP0001188_hyperpigmentation0.93220136
139MP0003938_abnormal_ear_development0.91196402
140MP0005391_vision/eye_phenotype0.90750677
141MP0001502_abnormal_circadian_rhythm0.90622814
142MP0000955_abnormal_spinal_cord0.89201753
143MP0002249_abnormal_larynx_morphology0.88586372
144MP0003698_abnormal_male_reproductive0.88349932
145MP0004264_abnormal_extraembryonic_tissu0.88312449
146MP0004043_abnormal_pH_regulation0.88054980
147MP0002925_abnormal_cardiovascular_devel0.87940984
148MP0000003_abnormal_adipose_tissue0.86893491
149MP0002234_abnormal_pharynx_morphology0.86632807
150MP0000026_abnormal_inner_ear0.85743490
151MP0008872_abnormal_physiological_respon0.85574494
152MP0002184_abnormal_innervation0.85533637
153MP0008770_decreased_survivor_rate0.85338406
154MP0004811_abnormal_neuron_physiology0.85144440
155MP0002928_abnormal_bile_duct0.84427305
156MP0000653_abnormal_sex_gland0.82505678
157MP0000647_abnormal_sebaceous_gland0.82379415

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.74209258
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.74209258
3Pancreatic cysts (HP:0001737)3.50721730
4Nephronophthisis (HP:0000090)3.20324901
5Pancreatic fibrosis (HP:0100732)3.20118496
6Hyperacusis (HP:0010780)3.04482715
7Heterotopia (HP:0002282)3.04255572
8Increased nuchal translucency (HP:0010880)3.03260471
9True hermaphroditism (HP:0010459)3.01723952
10Astrocytoma (HP:0009592)3.01585429
11Abnormality of the astrocytes (HP:0100707)3.01585429
12Volvulus (HP:0002580)2.99401194
13Abnormality of midbrain morphology (HP:0002418)2.99212632
14Molar tooth sign on MRI (HP:0002419)2.99212632
15Hyperventilation (HP:0002883)2.98315509
16Abnormality of the 4th metacarpal (HP:0010012)2.96112369
17Ependymoma (HP:0002888)2.91773908
18Chronic hepatic failure (HP:0100626)2.86275005
19Congenital stationary night blindness (HP:0007642)2.80026146
20Renal duplication (HP:0000075)2.77997244
21Renovascular hypertension (HP:0100817)2.76244641
22Abnormality of the renal medulla (HP:0100957)2.70566948
23Elfin facies (HP:0004428)2.70280780
24Macroorchidism (HP:0000053)2.67331021
25Insomnia (HP:0100785)2.66040362
26Facial hemangioma (HP:0000329)2.59042146
27Abnormality of the labia minora (HP:0012880)2.57894971
28Lissencephaly (HP:0001339)2.55191849
29Abnormality of the diencephalon (HP:0010662)2.51672074
30Attenuation of retinal blood vessels (HP:0007843)2.45991080
31Intestinal atresia (HP:0011100)2.43866687
32Medial flaring of the eyebrow (HP:0010747)2.42848587
33Obsessive-compulsive behavior (HP:0000722)2.40966653
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.40754565
35Glioma (HP:0009733)2.40682534
36Overriding aorta (HP:0002623)2.40574731
37Pendular nystagmus (HP:0012043)2.36775074
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.35947484
39Neoplasm of the oral cavity (HP:0100649)2.31864358
40Cerebellar dysplasia (HP:0007033)2.31800179
41Trigonocephaly (HP:0000243)2.29166668
42Abnormality of the fingertips (HP:0001211)2.28089358
43Medulloblastoma (HP:0002885)2.27626214
44Protruding tongue (HP:0010808)2.27472236
45Chromsome breakage (HP:0040012)2.27438701
46Septo-optic dysplasia (HP:0100842)2.27217167
47Broad-based gait (HP:0002136)2.26308935
48Progressive cerebellar ataxia (HP:0002073)2.25732254
49Abnormality of the ileum (HP:0001549)2.25067287
50Type II lissencephaly (HP:0007260)2.24755468
51Aplasia/Hypoplasia of the patella (HP:0006498)2.24621475
52Aplasia/Hypoplasia of the sternum (HP:0006714)2.23938657
53Optic nerve hypoplasia (HP:0000609)2.22895112
54Meckel diverticulum (HP:0002245)2.21933919
55Oligodactyly (HP:0012165)2.18724111
56Sclerocornea (HP:0000647)2.18413626
57Shallow orbits (HP:0000586)2.18033946
58Abnormality of the renal collecting system (HP:0004742)2.16595887
59Cystic liver disease (HP:0006706)2.16491795
60Gait imbalance (HP:0002141)2.16343024
61Retinal dysplasia (HP:0007973)2.16315095
62Ankyloglossia (HP:0010296)2.15499988
63Drooling (HP:0002307)2.15339349
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13601761
65Broad thumb (HP:0011304)2.13283822
66Nephrogenic diabetes insipidus (HP:0009806)2.13238897
67Gaze-evoked nystagmus (HP:0000640)2.11410578
68Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.08976940
69Short 1st metacarpal (HP:0010034)2.08976940
70Bilateral microphthalmos (HP:0007633)2.08224215
71Sacral dimple (HP:0000960)2.05182380
72Bony spicule pigmentary retinopathy (HP:0007737)2.04695880
73Anophthalmia (HP:0000528)2.03693341
74Abnormality of the renal cortex (HP:0011035)2.03543649
75Neoplasm of striated muscle (HP:0009728)2.02187290
76Anencephaly (HP:0002323)2.00947588
77Congenital primary aphakia (HP:0007707)2.00778783
78Anal stenosis (HP:0002025)2.00001337
79Genital tract atresia (HP:0001827)1.99421780
80Short phalanx of the thumb (HP:0009660)1.98809401
81Papillary thyroid carcinoma (HP:0002895)1.98025235
82Vaginal atresia (HP:0000148)1.97916978
83Abnormality of the pons (HP:0007361)1.95311711
84Megalocornea (HP:0000485)1.95123469
85Pointed chin (HP:0000307)1.94970691
86Aqueductal stenosis (HP:0002410)1.94313748
87Flat cornea (HP:0007720)1.93678265
88Small hand (HP:0200055)1.92298797
89Duplicated collecting system (HP:0000081)1.91954723
90Hypochromic microcytic anemia (HP:0004840)1.91587293
91Transitional cell carcinoma of the bladder (HP:0006740)1.91549078
92Sloping forehead (HP:0000340)1.91471987
93Bowel diverticulosis (HP:0005222)1.91130777
94Abnormality of chromosome segregation (HP:0002916)1.91118726
95Neoplasm of the heart (HP:0100544)1.90809147
96Excessive salivation (HP:0003781)1.90116688
97Abnormality of the lower motor neuron (HP:0002366)1.90046438
98Hypoplasia of the pons (HP:0012110)1.89217169
99Long eyelashes (HP:0000527)1.88787344
100Abnormal number of incisors (HP:0011064)1.88284614
101Birth length less than 3rd percentile (HP:0003561)1.87158457
102Cortical dysplasia (HP:0002539)1.86137655
103Chorioretinal atrophy (HP:0000533)1.85884180
104Broad phalanges of the hand (HP:0009768)1.84985674
105Coronal craniosynostosis (HP:0004440)1.84828685
106Abnormality of chromosome stability (HP:0003220)1.84680730
107Focal motor seizures (HP:0011153)1.84664277
108Abnormal rod and cone electroretinograms (HP:0008323)1.84461215
109Prominent nose (HP:0000448)1.84355259
110Poor coordination (HP:0002370)1.84115609
111Postaxial foot polydactyly (HP:0001830)1.83902658
112Leiomyosarcoma (HP:0100243)1.83388983
113Uterine leiomyosarcoma (HP:0002891)1.83388983
114Truncal obesity (HP:0001956)1.82946058
115Malignant gastrointestinal tract tumors (HP:0006749)1.81936585
116Gastrointestinal carcinoma (HP:0002672)1.81936585
117Preaxial hand polydactyly (HP:0001177)1.81723174
118Broad finger (HP:0001500)1.81699815
119Gastrointestinal atresia (HP:0002589)1.81144089
120Inability to walk (HP:0002540)1.80143709
121Shawl scrotum (HP:0000049)1.79968048
122Oligodactyly (hands) (HP:0001180)1.79901228
123Focal seizures (HP:0007359)1.79845379
124Deviation of the hallux (HP:0010051)1.79662787
125Patellar dislocation (HP:0002999)1.79590801
126Hallux valgus (HP:0001822)1.79464346
127Colon cancer (HP:0003003)1.78735123
128Abnormal drinking behavior (HP:0030082)1.78401848
129Polydipsia (HP:0001959)1.78401848
130Midline defect of the nose (HP:0004122)1.78353834
131Proximal placement of thumb (HP:0009623)1.78301190
132Hepatoblastoma (HP:0002884)1.77485343
133Ectopic kidney (HP:0000086)1.76160982
134Rib fusion (HP:0000902)1.76142297
135Absent speech (HP:0001344)1.75995967
136Bladder carcinoma (HP:0002862)1.74967152
137Bladder neoplasm (HP:0009725)1.74967152
138Vesicoureteral reflux (HP:0000076)1.74562252
139Spina bifida occulta (HP:0003298)1.74423517
140Absent/shortened dynein arms (HP:0200106)1.74128902
141Dynein arm defect of respiratory motile cilia (HP:0012255)1.74128902
142Genetic anticipation (HP:0003743)1.74057325
143Abolished electroretinogram (ERG) (HP:0000550)1.73435396
144Neoplasm of the adrenal cortex (HP:0100641)1.72400366
145Abnormality of the 1st metacarpal (HP:0010009)1.72281689
146Abnormality of DNA repair (HP:0003254)1.71804312
147Attention deficit hyperactivity disorder (HP:0007018)1.71551784
148Supernumerary spleens (HP:0009799)1.71141337
149Tubular atrophy (HP:0000092)1.70937772
150Narrow palate (HP:0000189)1.70774796
151Absent thumb (HP:0009777)1.70229139
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.70051184
153Supernumerary ribs (HP:0005815)1.69526150
154Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69258992
155Deviation of the thumb (HP:0009603)1.69161235
156Pachygyria (HP:0001302)1.68506364
157Methylmalonic acidemia (HP:0002912)1.67993344
158Esophageal atresia (HP:0002032)1.67696664
159Postaxial hand polydactyly (HP:0001162)1.66817530
160Dandy-Walker malformation (HP:0001305)1.66262295
161Smooth philtrum (HP:0000319)1.65723468
162Cupped ear (HP:0000378)1.65712772
163Triphalangeal thumb (HP:0001199)1.65103769
164Atresia of the external auditory canal (HP:0000413)1.64558042
165Absent rod-and cone-mediated responses on ERG (HP:0007688)1.63831334
166Progressive inability to walk (HP:0002505)1.63256195
167Febrile seizures (HP:0002373)1.63090269
168Tented upper lip vermilion (HP:0010804)1.63084795
169Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.61431502
170Hypoplastic labia majora (HP:0000059)1.60571565
171Broad palm (HP:0001169)1.59123606
172Hypoplasia of the maxilla (HP:0000327)1.58376679
173Male infertility (HP:0003251)1.57148349
174Abnormality of the carotid arteries (HP:0005344)1.57045533
175Urethral obstruction (HP:0000796)1.56214521
176Broad phalanx (HP:0006009)1.55535900
177Genu recurvatum (HP:0002816)1.55312812
178Rhabdomyosarcoma (HP:0002859)1.55102262
179Cafe-au-lait spot (HP:0000957)1.53290057
180Abnormality of oral frenula (HP:0000190)1.52650295
181Enlarged penis (HP:0000040)1.52473533
182Subacute progressive viral hepatitis (HP:0006572)1.52287329
183Patellar aplasia (HP:0006443)1.52185239
184Lymphangioma (HP:0100764)1.52147910
185Increased number of teeth (HP:0011069)1.51938812

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.58719125
2FRK4.34967419
3CDC73.25979031
4LATS13.13541407
5BRD43.04320619
6CASK2.99634122
7ZAK2.70870757
8ICK2.68540868
9NEK22.50753194
10WNK32.44986414
11MARK12.30774235
12MAP3K102.09514783
13EEF2K2.03577502
14TYRO32.00747765
15TRIB31.94926676
16LATS21.91344347
17MAP4K21.89842322
18CAMK1G1.70486902
19INSRR1.69030480
20PKN21.65638186
21CAMK1D1.64934299
22WNK41.62712056
23NUAK11.61387150
24STK38L1.59442079
25TNIK1.58262572
26MAP3K91.55115114
27PDGFRA1.52993312
28KSR11.52522791
29TTK1.50917133
30FGFR21.47757763
31TAOK11.45998982
32ACVR1B1.45331157
33CHEK21.43330235
34PINK11.43295881
35TLK11.39423194
36MTOR1.38930828
37MAP2K71.38763907
38ADRBK21.37034025
39RIPK11.34787727
40BCKDK1.34576587
41STK31.32316385
42EPHA41.31547808
43PRKD31.31468222
44SIK21.30949730
45WEE11.28080427
46GRK11.27874650
47PAK61.26907579
48MAP3K41.22132369
49ALK1.21121583
50CDK61.20898185
51ATR1.16503090
52PLK41.15816141
53DDR21.15172414
54CHEK11.14866256
55NTRK21.11929872
56BCR1.10226606
57SRPK11.10003206
58CDK91.09529844
59EIF2AK31.08745248
60EPHB21.08528226
61CDK70.99181479
62CDK40.98032820
63AKT30.96479150
64DMPK0.95134354
65PLK30.95010809
66BRSK20.94998457
67MELK0.94063053
68MKNK20.92583872
69TAOK30.92270752
70TRIM280.91837177
71ERBB30.91773679
72ATM0.91423822
73STK380.89853994
74DYRK1B0.89366403
75ERBB20.89077157
76CDK20.87888903
77TAF10.87539958
78CDC42BPA0.87506152
79DYRK30.87082165
80FGFR10.86650588
81PLK10.86273910
82VRK10.85484393
83MARK20.84271838
84MKNK10.82749713
85PLK20.81972827
86PRKCG0.80761740
87SGK2230.80100975
88SGK4940.80100975
89CDK10.78939788
90NLK0.78022803
91PDGFRB0.77955207
92DYRK1A0.77751915
93CSNK1A1L0.75750960
94MAP3K60.75317228
95NEK10.75257181
96BMPR1B0.73690807
97CSNK1D0.73155975
98BRSK10.72632099
99CSNK1G10.70351122
100SIK10.70014753
101TGFBR10.69712721
102RET0.69319377
103AURKB0.67612453
104SGK30.66838613
105DYRK20.65497107
106UHMK10.65136954
107KSR20.64721056
108PRKAA10.64230702
109PAK20.63877772
110STK110.62882526
111CDK30.62690848
112PNCK0.62372786
113CSNK1E0.62149611
114RPS6KB20.61819797
115STK390.60707963
116CAMK40.60595982
117OXSR10.60378393
118AKT20.59850600
119GSK3B0.59229041
120PRKDC0.57563768
121MAPK100.56941133
122FGFR30.56891048
123NTRK30.56605295
124MAPK150.56408869
125MAPK140.55987686
126MINK10.55912720
127CSNK1G30.55111043
128ADRBK10.54006461
129CSNK1G20.53992306
130PRKCE0.53544470
131HIPK20.53141063
132LMTK20.52933970
133PTK60.50764343
134EPHA30.49462686
135PAK30.49378185
136DAPK20.49157541
137WNK10.47591524
138MAP3K80.47539968
139EIF2AK20.47316620
140MAPK130.47096574
141SGK20.46998278
142SCYL20.46751442
143MAPK80.46476866
144PHKG10.45480301
145PHKG20.45480301
146MAP2K40.44170047
147AKT10.43707238
148BMX0.43703166
149MAPK90.43678385
150STK40.43161425
151MAP3K70.42968068
152PASK0.36877350
153CSNK1A10.36718232
154CAMK10.36536759
155PKN10.35351517
156SGK10.35036378

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.10679119
2Basal transcription factors_Homo sapiens_hsa030222.26234272
3mRNA surveillance pathway_Homo sapiens_hsa030152.20780352
4Cell cycle_Homo sapiens_hsa041102.11250362
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02987754
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02793053
7Taste transduction_Homo sapiens_hsa047422.01750905
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95229531
9Basal cell carcinoma_Homo sapiens_hsa052171.90883992
10Non-homologous end-joining_Homo sapiens_hsa034501.82130572
11RNA polymerase_Homo sapiens_hsa030201.80880737
12mTOR signaling pathway_Homo sapiens_hsa041501.79556198
13Butanoate metabolism_Homo sapiens_hsa006501.78215029
14RNA transport_Homo sapiens_hsa030131.70761694
15Hippo signaling pathway_Homo sapiens_hsa043901.69194721
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69181548
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.69172394
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.68604876
19RNA degradation_Homo sapiens_hsa030181.62541507
20Hedgehog signaling pathway_Homo sapiens_hsa043401.61251972
21MicroRNAs in cancer_Homo sapiens_hsa052061.60796095
22Morphine addiction_Homo sapiens_hsa050321.60644758
23Oocyte meiosis_Homo sapiens_hsa041141.60594505
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60486988
25Endometrial cancer_Homo sapiens_hsa052131.59933133
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59482618
27Dorso-ventral axis formation_Homo sapiens_hsa043201.59290919
28Linoleic acid metabolism_Homo sapiens_hsa005911.57834160
29Colorectal cancer_Homo sapiens_hsa052101.56877382
30Chronic myeloid leukemia_Homo sapiens_hsa052201.56371229
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.54128495
32Lysine degradation_Homo sapiens_hsa003101.53830286
33Mismatch repair_Homo sapiens_hsa034301.51529219
34Selenocompound metabolism_Homo sapiens_hsa004501.47710427
35Phototransduction_Homo sapiens_hsa047441.46191248
36One carbon pool by folate_Homo sapiens_hsa006701.45066995
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44497190
38DNA replication_Homo sapiens_hsa030301.42968592
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.42387143
40Glioma_Homo sapiens_hsa052141.37046257
41GABAergic synapse_Homo sapiens_hsa047271.36014616
42Wnt signaling pathway_Homo sapiens_hsa043101.35988133
43Non-small cell lung cancer_Homo sapiens_hsa052231.31005303
44Fanconi anemia pathway_Homo sapiens_hsa034601.29995591
45Adherens junction_Homo sapiens_hsa045201.26833750
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26440607
47Spliceosome_Homo sapiens_hsa030401.26319490
48Longevity regulating pathway - mammal_Homo sapiens_hsa042111.26022133
49Ether lipid metabolism_Homo sapiens_hsa005651.25928115
50Axon guidance_Homo sapiens_hsa043601.24780030
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21941034
52Notch signaling pathway_Homo sapiens_hsa043301.21534535
53Type II diabetes mellitus_Homo sapiens_hsa049301.16213557
54Renal cell carcinoma_Homo sapiens_hsa052111.15899354
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15353034
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14670160
57TGF-beta signaling pathway_Homo sapiens_hsa043501.12074409
58Pancreatic cancer_Homo sapiens_hsa052121.09761061
59ErbB signaling pathway_Homo sapiens_hsa040121.09396222
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08813285
61AMPK signaling pathway_Homo sapiens_hsa041521.08424380
62Serotonergic synapse_Homo sapiens_hsa047261.07453941
63Propanoate metabolism_Homo sapiens_hsa006401.07290683
64Choline metabolism in cancer_Homo sapiens_hsa052311.05604656
65Proteoglycans in cancer_Homo sapiens_hsa052051.02402287
66GnRH signaling pathway_Homo sapiens_hsa049121.01618668
67Estrogen signaling pathway_Homo sapiens_hsa049151.01606103
68Small cell lung cancer_Homo sapiens_hsa052221.01546055
69Central carbon metabolism in cancer_Homo sapiens_hsa052301.01076759
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00257679
71VEGF signaling pathway_Homo sapiens_hsa043701.00034931
72Bladder cancer_Homo sapiens_hsa052190.99329796
73Base excision repair_Homo sapiens_hsa034100.98985504
74Alcoholism_Homo sapiens_hsa050340.98648611
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96761841
76HTLV-I infection_Homo sapiens_hsa051660.95442718
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94643070
78Prostate cancer_Homo sapiens_hsa052150.94408182
79Gap junction_Homo sapiens_hsa045400.93901535
80Huntingtons disease_Homo sapiens_hsa050160.91455425
81Melanogenesis_Homo sapiens_hsa049160.91226844
82Long-term potentiation_Homo sapiens_hsa047200.90681832
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89090343
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.88585110
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88230113
86Oxidative phosphorylation_Homo sapiens_hsa001900.88137539
87p53 signaling pathway_Homo sapiens_hsa041150.87777784
88Insulin signaling pathway_Homo sapiens_hsa049100.85541061
89Nucleotide excision repair_Homo sapiens_hsa034200.85379331
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84664801
91Dopaminergic synapse_Homo sapiens_hsa047280.84626150
92Systemic lupus erythematosus_Homo sapiens_hsa053220.84198759
93Viral carcinogenesis_Homo sapiens_hsa052030.83257601
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82812381
95Homologous recombination_Homo sapiens_hsa034400.82798171
96MAPK signaling pathway_Homo sapiens_hsa040100.82280178
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81743386
98Protein export_Homo sapiens_hsa030600.81452318
99Pathways in cancer_Homo sapiens_hsa052000.80677628
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80610685
101Tight junction_Homo sapiens_hsa045300.80431535
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79920582
103Amphetamine addiction_Homo sapiens_hsa050310.79741009
104Olfactory transduction_Homo sapiens_hsa047400.79700375
105FoxO signaling pathway_Homo sapiens_hsa040680.78767274
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78168963
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.77596401
108Parkinsons disease_Homo sapiens_hsa050120.76711572
109Calcium signaling pathway_Homo sapiens_hsa040200.76314868
110Circadian rhythm_Homo sapiens_hsa047100.75078990
111Sulfur relay system_Homo sapiens_hsa041220.74318299
112Glutamatergic synapse_Homo sapiens_hsa047240.74179802
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73237999
114Tryptophan metabolism_Homo sapiens_hsa003800.71949207
115Circadian entrainment_Homo sapiens_hsa047130.71842398
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70745149
117Cardiac muscle contraction_Homo sapiens_hsa042600.70571582
118Long-term depression_Homo sapiens_hsa047300.69971035
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69879527
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69805753
121Regulation of autophagy_Homo sapiens_hsa041400.68289155
122Purine metabolism_Homo sapiens_hsa002300.68038820
123Steroid biosynthesis_Homo sapiens_hsa001000.68001801
124Viral myocarditis_Homo sapiens_hsa054160.67923628
125Melanoma_Homo sapiens_hsa052180.67563594
126cAMP signaling pathway_Homo sapiens_hsa040240.66995367
127Oxytocin signaling pathway_Homo sapiens_hsa049210.66718178
128Prolactin signaling pathway_Homo sapiens_hsa049170.65905973
129Rap1 signaling pathway_Homo sapiens_hsa040150.65746247
130Cholinergic synapse_Homo sapiens_hsa047250.65685483
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65646975
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65611757
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65151271
134Inositol phosphate metabolism_Homo sapiens_hsa005620.64658261
135Fatty acid biosynthesis_Homo sapiens_hsa000610.63800465
136Insulin secretion_Homo sapiens_hsa049110.63182721
137Nitrogen metabolism_Homo sapiens_hsa009100.62313792
138Thyroid cancer_Homo sapiens_hsa052160.61744701
139Glucagon signaling pathway_Homo sapiens_hsa049220.61339942
140Cocaine addiction_Homo sapiens_hsa050300.61339192
141Focal adhesion_Homo sapiens_hsa045100.61203923
142Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60508668
143ABC transporters_Homo sapiens_hsa020100.60324853
144Salivary secretion_Homo sapiens_hsa049700.59522603
145Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59043731
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54119770
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52721190
148Caffeine metabolism_Homo sapiens_hsa002320.52705798
149Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48826977
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48440877
151Pyrimidine metabolism_Homo sapiens_hsa002400.45715184
152Steroid hormone biosynthesis_Homo sapiens_hsa001400.45617210
153Ovarian steroidogenesis_Homo sapiens_hsa049130.44886838
154Retinol metabolism_Homo sapiens_hsa008300.38461146
155Ribosome_Homo sapiens_hsa030100.38163821

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