USP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)6.54524173
2polyketide metabolic process (GO:0030638)6.54524173
3doxorubicin metabolic process (GO:0044598)6.54524173
4protein localization to kinetochore (GO:0034501)5.76172394
5Golgi transport vesicle coating (GO:0048200)5.61035379
6COPI coating of Golgi vesicle (GO:0048205)5.61035379
7negative regulation of telomerase activity (GO:0051974)5.17557185
8regulation of mammary gland epithelial cell proliferation (GO:0033599)5.11280193
9maintenance of protein location in nucleus (GO:0051457)5.09837601
10negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.07122123
11histone H4-K8 acetylation (GO:0043982)5.01140194
12histone H4-K5 acetylation (GO:0043981)5.01140194
13heterochromatin organization (GO:0070828)4.99862805
14mitotic sister chromatid segregation (GO:0000070)4.89259400
15proline transport (GO:0015824)4.76018669
16synaptic vesicle maturation (GO:0016188)4.72547922
17negative regulation of epidermis development (GO:0045683)4.64901809
18regulation of telomere maintenance via telomerase (GO:0032210)4.64270322
19negative regulation of cell cycle G2/M phase transition (GO:1902750)4.60794887
20protein retention in ER lumen (GO:0006621)4.49993193
21DNA replication-dependent nucleosome organization (GO:0034723)4.46876650
22DNA replication-dependent nucleosome assembly (GO:0006335)4.46876650
23histone H4-K12 acetylation (GO:0043983)4.44910006
24regulation of response to osmotic stress (GO:0047484)4.40539321
25maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.30738879
26pre-miRNA processing (GO:0031054)4.28312125
27retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.27382863
28sister chromatid segregation (GO:0000819)4.24196450
29negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.22732786
30aminoglycoside antibiotic metabolic process (GO:0030647)4.13216054
31somite rostral/caudal axis specification (GO:0032525)4.04521624
32proline biosynthetic process (GO:0006561)4.01003535
33cytoskeletal anchoring at plasma membrane (GO:0007016)3.97628852
34regulation of nuclear cell cycle DNA replication (GO:0033262)3.97232492
35protein localization to chromosome, centromeric region (GO:0071459)3.96833593
36protein localization to endosome (GO:0036010)3.83750342
37rRNA transcription (GO:0009303)3.82006609
38negative regulation of cell size (GO:0045792)3.78959066
39adherens junction assembly (GO:0034333)3.76824508
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.75338458
41regulation of translational fidelity (GO:0006450)3.74430050
42chromatin assembly (GO:0031497)3.69663506
43histone H4-K16 acetylation (GO:0043984)3.64453631
44DNA unwinding involved in DNA replication (GO:0006268)3.63869444
45negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.62185098
46regulation of translation in response to stress (GO:0043555)3.62126687
47muscle organ morphogenesis (GO:0048644)3.61649480
48histone arginine methylation (GO:0034969)3.61361822
49focal adhesion assembly (GO:0048041)3.60852195
50cell-substrate adherens junction assembly (GO:0007045)3.60852195
51response to dietary excess (GO:0002021)3.60142334
52nuclear pore complex assembly (GO:0051292)3.59565570
53peptidyl-arginine omega-N-methylation (GO:0035247)3.55938749
54regulation of MHC class I biosynthetic process (GO:0045343)3.53013533
55phenol-containing compound catabolic process (GO:0019336)3.49541203
56maternal placenta development (GO:0001893)3.48715916
57nuclear pore organization (GO:0006999)3.48077276
58planar cell polarity pathway involved in neural tube closure (GO:0090179)3.44673029
59regulation of telomerase activity (GO:0051972)3.43959588
60notochord development (GO:0030903)3.42943883
61activation of Rac GTPase activity (GO:0032863)3.39636478
62cullin deneddylation (GO:0010388)3.35104878
63pentose-phosphate shunt (GO:0006098)3.34574618
64protein complex localization (GO:0031503)3.33137187
65regulation of translational termination (GO:0006449)3.32363219
66cell-substrate junction assembly (GO:0007044)3.28684666
67regulation of early endosome to late endosome transport (GO:2000641)3.19813457
68negative regulation of potassium ion transmembrane transport (GO:1901380)3.18862748
69detection of temperature stimulus (GO:0016048)3.16815989
70cellular modified amino acid catabolic process (GO:0042219)3.16253416
71regulation of gene silencing by RNA (GO:0060966)3.15797643
72regulation of posttranscriptional gene silencing (GO:0060147)3.15797643
73regulation of gene silencing by miRNA (GO:0060964)3.15797643
74DNA duplex unwinding (GO:0032508)3.15234236
75regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.15218019
76DNA geometric change (GO:0032392)3.11723058
77positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.11182968
78NLS-bearing protein import into nucleus (GO:0006607)3.10375416
79hormone catabolic process (GO:0042447)3.10289578
80barbed-end actin filament capping (GO:0051016)3.09972287
81regulation of NFAT protein import into nucleus (GO:0051532)3.09495838
82intracellular estrogen receptor signaling pathway (GO:0030520)3.09385464
83maintenance of protein localization in organelle (GO:0072595)3.08998966
84regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.08207605
85hemidesmosome assembly (GO:0031581)3.08183836
86negative regulation of telomere maintenance (GO:0032205)3.06175799
87peptidyl-arginine methylation (GO:0018216)3.05255783
88peptidyl-arginine N-methylation (GO:0035246)3.05255783
89positive regulation of synapse maturation (GO:0090129)3.05057457
90protein-DNA complex disassembly (GO:0032986)3.04625208
91nucleosome disassembly (GO:0006337)3.04625208
92cytidine deamination (GO:0009972)3.03234754
93cytidine metabolic process (GO:0046087)3.03234754
94cytidine catabolic process (GO:0006216)3.03234754
95mitotic chromosome condensation (GO:0007076)3.02737172
96coenzyme catabolic process (GO:0009109)3.02525995
97DNA replication checkpoint (GO:0000076)3.01686057
98positive regulation of DNA-dependent DNA replication (GO:2000105)3.01397534
99cellular protein complex localization (GO:0034629)3.00695985
100protein maturation by protein folding (GO:0022417)2.99358635
101apoptotic process involved in morphogenesis (GO:0060561)2.99181551
102negative regulation of epidermal cell differentiation (GO:0045605)2.99011050
103negative regulation of microtubule polymerization (GO:0031115)2.97169905
104NADPH regeneration (GO:0006740)2.95985688
105formation of translation preinitiation complex (GO:0001731)2.95964537
106epithelial cell differentiation involved in prostate gland development (GO:0060742)2.94157333
107microtubule severing (GO:0051013)2.93852188
108regulation of hippo signaling (GO:0035330)2.93731671
109cell migration in hindbrain (GO:0021535)2.93199593
110basement membrane organization (GO:0071711)2.92343249
111receptor recycling (GO:0001881)2.92238865
112layer formation in cerebral cortex (GO:0021819)2.91257267
113intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.90689418
114RNA stabilization (GO:0043489)2.90435584
115mRNA stabilization (GO:0048255)2.90435584
116regulation of glucose import in response to insulin stimulus (GO:2001273)2.90190046
117glutamate secretion (GO:0014047)2.89726846
118regulation of cilium movement (GO:0003352)2.88219641
119glucose catabolic process (GO:0006007)2.87477578
120apoptotic DNA fragmentation (GO:0006309)2.86690462
121positive regulation of protein deacetylation (GO:0090312)2.86507075
122protein deneddylation (GO:0000338)2.86424364
123branching involved in mammary gland duct morphogenesis (GO:0060444)2.85392982
124glycolytic process (GO:0006096)2.84529735
125regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.83945609
126primitive streak formation (GO:0090009)2.83433980
127negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.82045687
128glucose 6-phosphate metabolic process (GO:0051156)2.80970691
129mitochondrion distribution (GO:0048311)2.80926736
130activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.80634764
131positive regulation of histone deacetylation (GO:0031065)2.78528725
132regulation of microtubule-based movement (GO:0060632)2.77391194
133positive regulation of nuclease activity (GO:0032075)2.76082154
134nucleoside transmembrane transport (GO:1901642)2.73668151
135synaptic vesicle docking involved in exocytosis (GO:0016081)2.73485576
136regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.73466436
137positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.73466436
138negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.72924354
139semaphorin-plexin signaling pathway (GO:0071526)2.72405283
140protein polyglutamylation (GO:0018095)2.71393965
141epithelial cell-cell adhesion (GO:0090136)2.71319129
142vesicle coating (GO:0006901)2.70681093
143mitotic nuclear envelope reassembly (GO:0007084)2.70496265
144nuclear envelope reassembly (GO:0031468)2.70496265
145nucleobase-containing small molecule interconversion (GO:0015949)2.69056206
146retinoic acid receptor signaling pathway (GO:0048384)2.67032232
147positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.65861228
148mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.61127098
149negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.58998277
150establishment of integrated proviral latency (GO:0075713)2.56900740
151protein targeting to plasma membrane (GO:0072661)2.56882196
152protein export from nucleus (GO:0006611)2.56084631
153proline metabolic process (GO:0006560)2.54919310
154glucocorticoid receptor signaling pathway (GO:0042921)2.53349685
155sodium ion export (GO:0071436)2.52079389
156stress fiber assembly (GO:0043149)2.51196214
157regulation of mitotic spindle organization (GO:0060236)2.50672219
158endoplasmic reticulum unfolded protein response (GO:0030968)2.50318165
159mitotic G1 DNA damage checkpoint (GO:0031571)2.49811056
160pore complex assembly (GO:0046931)2.45572581
161ER-nucleus signaling pathway (GO:0006984)2.44849768
1623-UTR-mediated mRNA stabilization (GO:0070935)2.44055880
163cellular response to epidermal growth factor stimulus (GO:0071364)2.43012148
164regulation of nucleobase-containing compound transport (GO:0032239)2.42936285
165regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.42783249
166regulation of nuclease activity (GO:0032069)2.42409533
167peptidyl-proline hydroxylation (GO:0019511)2.42196766
168peptidyl-lysine dimethylation (GO:0018027)2.41599614
169regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.41053170
170chromosome condensation (GO:0030261)2.38290257
171mitochondrial fusion (GO:0008053)2.37926023
172monosaccharide biosynthetic process (GO:0046364)2.37826395
173convergent extension (GO:0060026)2.35944857
174NADH metabolic process (GO:0006734)2.35201315
175paraxial mesoderm development (GO:0048339)2.35010531
176gluconeogenesis (GO:0006094)2.33247372
177protein localization to microtubule (GO:0035372)2.31884417

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.96071507
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.55424382
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.55424382
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.55424382
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.31213650
6POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.16827909
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.74194792
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.71991277
9* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71479739
10* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.70445880
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.61974949
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.59821409
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.56631103
14ZFP281_18757296_ChIP-ChIP_E14_Mouse2.52917988
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.40501790
16ZNF263_19887448_ChIP-Seq_K562_Human2.39715435
17* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.33025071
18* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27712255
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.21145796
20* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.18789223
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09424680
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.07068157
23KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.06258381
24MYC_22102868_ChIP-Seq_BL_Human2.05298877
25TCF3_18692474_ChIP-Seq_MEFs_Mouse2.02061991
26VDR_21846776_ChIP-Seq_THP-1_Human1.99514676
27TCF3_18692474_ChIP-Seq_MESCs_Mouse1.96885240
28* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.95582246
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93475332
30* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89628757
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.87761232
32* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.87693541
33* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86847550
34CLOCK_20551151_ChIP-Seq_293T_Human1.86452257
35* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.84667027
36ZFP281_27345836_Chip-Seq_ESCs_Mouse1.82861186
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80396416
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.79754543
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76664685
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72449964
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.70434608
42SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.69412409
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.67387182
44* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64599683
45POU5F1_16518401_ChIP-PET_MESCs_Mouse1.61689846
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61278361
47CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.56893662
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.50129292
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49222339
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48889516
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.47594739
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47484778
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47365545
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46664125
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45521921
56TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.44100221
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43066719
58TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.42640121
59LXR_22292898_ChIP-Seq_THP-1_Human1.42196112
60* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.41055536
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40419478
62OCT4_18692474_ChIP-Seq_MEFs_Mouse1.39916430
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.37085178
64* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35369612
65* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35320837
66* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34261704
67* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.33767619
68* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33747332
69AR_21909140_ChIP-Seq_LNCAP_Human1.32862670
70POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.32313972
71TP53_22127205_ChIP-Seq_IMR90_Human1.31395919
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31213650
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.29905758
74KDM2B_26808549_Chip-Seq_K562_Human1.29041832
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28806631
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26935925
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26795143
78E2F1_17053090_ChIP-ChIP_MCF-7_Human1.26330660
79* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25535458
80* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24517705
81RARB_27405468_Chip-Seq_BRAIN_Mouse1.23619247
82ATF3_27146783_Chip-Seq_COLON_Human1.23524920
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.23516973
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22290606
85* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.21659345
86SMC4_20622854_ChIP-Seq_HELA_Human1.21114044
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.20660748
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.19762721
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19126908
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19064675
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18732137
92* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18585610
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18513084
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.17190495
95* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16857788
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16156528
97* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16029958
98P68_20966046_ChIP-Seq_HELA_Human1.15409699
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15157423
100CREB1_26743006_Chip-Seq_LNCaP_Human1.13694093
101* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.13635680
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.13549372
103KDM2B_26808549_Chip-Seq_JURKAT_Human1.12974630
104ELF1_20517297_ChIP-Seq_JURKAT_Human1.12964791
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11925477
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11514564
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11116650
108TCF7_22412390_ChIP-Seq_EML_Mouse1.10722655
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10449137
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10186237
111* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10143539
112* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09547774
113* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08571511
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08300092
115* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08278807
116RACK7_27058665_Chip-Seq_MCF-7_Human1.08265555
117SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08175406
118* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08134277
119* NANOG_16518401_ChIP-PET_MESCs_Mouse1.08086679
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07696871
121XRN2_22483619_ChIP-Seq_HELA_Human1.05868750
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05020019
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04959411
124SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04943423
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04607284
126* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02635825
127KDM2B_26808549_Chip-Seq_DND41_Human1.02292630
128YY1_22570637_ChIP-Seq_MALME-3M_Human1.00944770
129DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98898743
130TRIM28_21343339_ChIP-Seq_HEK293_Human0.98392159
131TET1_21490601_ChIP-Seq_MESCs_Mouse0.97391450
132UBF1/2_26484160_Chip-Seq_HMECs_Human0.97255329
133POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96198789
134TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96168028
135SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95961056
136KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95790386
137NANOG_16153702_ChIP-ChIP_HESCs_Human0.95612126
138* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95361694
139NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95343560
140NCOR1_26117541_ChIP-Seq_K562_Human0.93154703
141ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91388109
142CIITA_25753668_ChIP-Seq_RAJI_Human0.90433841
143P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90199159
144* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90168535

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004858_abnormal_nervous_system4.38091554
2MP0003705_abnormal_hypodermis_morpholog3.41263941
3MP0003122_maternal_imprinting3.29561419
4MP0008438_abnormal_cutaneous_collagen2.95520814
5MP0002877_abnormal_melanocyte_morpholog2.95446401
6MP0002653_abnormal_ependyma_morphology2.92416398
7MP0004264_abnormal_extraembryonic_tissu2.82363925
8MP0005394_taste/olfaction_phenotype2.81963577
9MP0005499_abnormal_olfactory_system2.81963577
10MP0010234_abnormal_vibrissa_follicle2.76709546
11MP0003890_abnormal_embryonic-extraembry2.72936377
12MP0004859_abnormal_synaptic_plasticity2.71685173
13MP0003011_delayed_dark_adaptation2.64988407
14MP0003123_paternal_imprinting2.64942440
15MP0003121_genomic_imprinting2.49444180
16MP0008961_abnormal_basal_metabolism2.46099682
17MP0000537_abnormal_urethra_morphology2.43430801
18MP0002254_reproductive_system_inflammat2.41146645
19MP0004957_abnormal_blastocyst_morpholog2.41000066
20MP0010352_gastrointestinal_tract_polyps2.37140426
21MP0005451_abnormal_body_composition2.36186279
22MP0004233_abnormal_muscle_weight2.35690428
23MP0004185_abnormal_adipocyte_glucose2.21545327
24MP0000751_myopathy2.15081092
25MP0008260_abnormal_autophagy2.15056597
26MP0010030_abnormal_orbit_morphology2.09928694
27MP0005076_abnormal_cell_differentiation2.08305416
28MP0002332_abnormal_exercise_endurance2.08205125
29MP0006292_abnormal_olfactory_placode2.05321839
30MP0006035_abnormal_mitochondrial_morpho2.00482796
31MP0003283_abnormal_digestive_organ1.98777240
32MP0004272_abnormal_basement_membrane1.91139473
33MP0005257_abnormal_intraocular_pressure1.77014590
34MP0005058_abnormal_lysosome_morphology1.76034411
35MP0001849_ear_inflammation1.74031543
36MP0005380_embryogenesis_phenotype1.70843288
37MP0001672_abnormal_embryogenesis/_devel1.70843288
38MP0000579_abnormal_nail_morphology1.65650427
39MP0005409_darkened_coat_color1.63890886
40MP0002088_abnormal_embryonic_growth/wei1.60672178
41MP0009672_abnormal_birth_weight1.59914527
42MP0000733_abnormal_muscle_development1.59271100
43MP0003984_embryonic_growth_retardation1.59215439
44MP0003183_abnormal_peptide_metabolism1.55805162
45MP0005501_abnormal_skin_physiology1.54993571
46MP0002796_impaired_skin_barrier1.53911075
47MP0004270_analgesia1.52211723
48MP0000747_muscle_weakness1.52105642
49MP0002909_abnormal_adrenal_gland1.51244214
50MP0000003_abnormal_adipose_tissue1.50964870
51MP0003091_abnormal_cell_migration1.49297466
52MP0005075_abnormal_melanosome_morpholog1.49267797
53MP0000350_abnormal_cell_proliferation1.48610749
54MP0001730_embryonic_growth_arrest1.45501541
55MP0001348_abnormal_lacrimal_gland1.44196321
56MP0005623_abnormal_meninges_morphology1.43942309
57MP0002089_abnormal_postnatal_growth/wei1.43074492
58MP0008057_abnormal_DNA_replication1.42732113
59MP0003787_abnormal_imprinting1.36761897
60MP0003111_abnormal_nucleus_morphology1.36112866
61MP0002085_abnormal_embryonic_tissue1.33559327
62MP0003453_abnormal_keratinocyte_physiol1.33543474
63MP0002084_abnormal_developmental_patter1.32605563
64MP0000678_abnormal_parathyroid_gland1.32096241
65MP0002269_muscular_atrophy1.31538830
66MP0003635_abnormal_synaptic_transmissio1.31211516
67MP0003119_abnormal_digestive_system1.31008096
68MP0002060_abnormal_skin_morphology1.30420208
69MP0003077_abnormal_cell_cycle1.30391648
70MP0009053_abnormal_anal_canal1.30077177
71MP0003385_abnormal_body_wall1.29905061
72MP0004197_abnormal_fetal_growth/weight/1.27246508
73MP0000955_abnormal_spinal_cord1.24862318
74MP0003693_abnormal_embryo_hatching1.24759939
75MP0000428_abnormal_craniofacial_morphol1.23701060
76MP0003938_abnormal_ear_development1.22841575
77MP0002086_abnormal_extraembryonic_tissu1.22823184
78MP0000762_abnormal_tongue_morphology1.22332907
79MP0008770_decreased_survivor_rate1.18637510
80MP0000467_abnormal_esophagus_morphology1.14545030
81MP0005266_abnormal_metabolism1.14431410
82MP0005621_abnormal_cell_physiology1.13307043
83MP0004133_heterotaxia1.13067812
84MP0002063_abnormal_learning/memory/cond1.12894405
85MP0002733_abnormal_thermal_nociception1.12654010
86MP0002249_abnormal_larynx_morphology1.12498812
87MP0001346_abnormal_lacrimal_gland1.12448081
88MP0002080_prenatal_lethality1.09544192
89MP0003115_abnormal_respiratory_system1.09233717
90MP0004811_abnormal_neuron_physiology1.08178053
91MP0002127_abnormal_cardiovascular_syste1.08037689
92MP0001299_abnormal_eye_distance/1.06404488
93MP0001697_abnormal_embryo_size1.05793166
94MP0001661_extended_life_span1.05561853
95MP0002751_abnormal_autonomic_nervous1.04753767
96MP0005666_abnormal_adipose_tissue1.04335024
97MP0002932_abnormal_joint_morphology1.03527105
98MP0003634_abnormal_glial_cell1.03316399
99MP0005375_adipose_tissue_phenotype1.03105064
100MP0002970_abnormal_white_adipose1.01733155
101MP0001293_anophthalmia1.00149160
102MP0001915_intracranial_hemorrhage0.99677180
103MP0009046_muscle_twitch0.99593609
104MP0003861_abnormal_nervous_system0.99370647
105MP0003137_abnormal_impulse_conducting0.97690715
106MP0000358_abnormal_cell_content/0.97444694
107MP0010630_abnormal_cardiac_muscle0.97349648
108MP0000566_synostosis0.97059140
109MP0002697_abnormal_eye_size0.97057691
110MP0003172_abnormal_lysosome_physiology0.96616019
111MP0002114_abnormal_axial_skeleton0.96594453
112MP0000462_abnormal_digestive_system0.95998950
113MP0002092_abnormal_eye_morphology0.95987980
114MP0002572_abnormal_emotion/affect_behav0.94766729
115MP0002184_abnormal_innervation0.94451672
116MP0002822_catalepsy0.94081941
117MP0010094_abnormal_chromosome_stability0.92226873
118MP0008789_abnormal_olfactory_epithelium0.92211835
119MP0002064_seizures0.92095282
120MP0001958_emphysema0.91152821
121MP0000750_abnormal_muscle_regeneration0.91105942
122MP0008932_abnormal_embryonic_tissue0.90114840
123MP0009840_abnormal_foam_cell0.89384647
124MP0002233_abnormal_nose_morphology0.88352202
125MP0002734_abnormal_mechanical_nocicepti0.87493938
126MP0003315_abnormal_perineum_morphology0.86358697
127MP0009278_abnormal_bone_marrow0.86058947
128MP0003329_amyloid_beta_deposits0.84286188
129MP0000049_abnormal_middle_ear0.83828135
130MP0003941_abnormal_skin_development0.83135474
131MP0009703_decreased_birth_body0.82605279
132MP0000759_abnormal_skeletal_muscle0.79510049
133MP0005275_abnormal_skin_tensile0.79186881
134MP0009780_abnormal_chondrocyte_physiolo0.78967801
135MP0002081_perinatal_lethality0.78946358
136MP0000749_muscle_degeneration0.77931369
137MP0008007_abnormal_cellular_replicative0.77581804
138MP0002896_abnormal_bone_mineralization0.77205355
139MP0008872_abnormal_physiological_respon0.76527927
140MP0003935_abnormal_craniofacial_develop0.76268283
141MP0009384_cardiac_valve_regurgitation0.76266490
142MP0000778_abnormal_nervous_system0.75524148
143MP0006138_congestive_heart_failure0.75091123
144MP0003279_aneurysm0.75040777
145MP0000013_abnormal_adipose_tissue0.74815701
146MP0000534_abnormal_ureter_morphology0.73779426
147MP0003566_abnormal_cell_adhesion0.72235893
148MP0003755_abnormal_palate_morphology0.70726713
149MP0005384_cellular_phenotype0.70132881
150MP0001970_abnormal_pain_threshold0.69510162
151MP0002925_abnormal_cardiovascular_devel0.68220912
152MP0000313_abnormal_cell_death0.68124429
153MP0003942_abnormal_urinary_system0.68060208
154MP0004087_abnormal_muscle_fiber0.65593867
155MP0002152_abnormal_brain_morphology0.64681239
156MP0005023_abnormal_wound_healing0.63923332

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)6.13137583
2Bilateral microphthalmos (HP:0007633)5.50089454
3Ependymoma (HP:0002888)4.81377883
4Hepatoblastoma (HP:0002884)4.55819490
5Multiple enchondromatosis (HP:0005701)4.21648042
6Hyperacusis (HP:0010780)4.11291943
7Hypochromic microcytic anemia (HP:0004840)4.01260116
8Premature rupture of membranes (HP:0001788)3.90949232
9Astrocytoma (HP:0009592)3.87184470
10Abnormality of the astrocytes (HP:0100707)3.87184470
11Amyotrophic lateral sclerosis (HP:0007354)3.65403850
12Protrusio acetabuli (HP:0003179)3.47658115
13Insomnia (HP:0100785)3.37111193
14Neoplasm of striated muscle (HP:0009728)3.34084696
15Rib fusion (HP:0000902)3.17345439
16Hand muscle atrophy (HP:0009130)3.15340207
17Resting tremor (HP:0002322)3.09124912
18Neoplasm of the heart (HP:0100544)3.06117298
19Distal lower limb amyotrophy (HP:0008944)2.98120210
20Rhabdomyosarcoma (HP:0002859)2.97153084
21Renal duplication (HP:0000075)2.92187380
22Generalized hypotonia (HP:0001290)2.92168901
23Upper limb amyotrophy (HP:0009129)2.90915603
24Distal upper limb amyotrophy (HP:0007149)2.90915603
25Ragged-red muscle fibers (HP:0003200)2.77923326
26Ulnar bowing (HP:0003031)2.75148653
27Vertebral compression fractures (HP:0002953)2.73932711
28Glioma (HP:0009733)2.71775085
29Achilles tendon contracture (HP:0001771)2.71354827
30Abnormality of the salivary glands (HP:0010286)2.66507846
31Difficulty running (HP:0009046)2.66425214
32Centrally nucleated skeletal muscle fibers (HP:0003687)2.64856223
33Angiofibromas (HP:0010615)2.60711418
34Adenoma sebaceum (HP:0009720)2.60711418
35Shallow orbits (HP:0000586)2.59702268
36Horizontal nystagmus (HP:0000666)2.53248116
37Lower limb amyotrophy (HP:0007210)2.52776275
38Increased connective tissue (HP:0009025)2.47816185
39Back pain (HP:0003418)2.45589424
40Abnormality of the Achilles tendon (HP:0005109)2.43925255
41Large earlobe (HP:0009748)2.42903138
42Atrophy/Degeneration involving motor neurons (HP:0007373)2.42024516
43Nephroblastoma (Wilms tumor) (HP:0002667)2.41186738
44Pseudobulbar signs (HP:0002200)2.41092186
45Trismus (HP:0000211)2.40246498
46Abnormality of the musculature of the hand (HP:0001421)2.40095316
47Cholecystitis (HP:0001082)2.39173309
48Abnormal gallbladder physiology (HP:0012438)2.39173309
49Malignant neoplasm of the central nervous system (HP:0100836)2.37344717
50Tetraplegia (HP:0002445)2.37015905
51Testicular atrophy (HP:0000029)2.36518306
52Long palpebral fissure (HP:0000637)2.36230053
53Embryonal renal neoplasm (HP:0011794)2.34881443
54Short nail (HP:0001799)2.34698512
55Broad face (HP:0000283)2.32435552
56Fused cervical vertebrae (HP:0002949)2.31548054
57Spinal rigidity (HP:0003306)2.29884780
58Amblyopia (HP:0000646)2.27453005
59Difficulty climbing stairs (HP:0003551)2.26805326
60Pointed chin (HP:0000307)2.24389377
61Overriding aorta (HP:0002623)2.23551098
62Short humerus (HP:0005792)2.23415453
63Hypopigmentation of the fundus (HP:0007894)2.23238176
64Preauricular skin tag (HP:0000384)2.23063549
65Fragile skin (HP:0001030)2.22169711
66Asymmetry of the thorax (HP:0001555)2.21885151
67Distal lower limb muscle weakness (HP:0009053)2.19752981
68Bladder diverticulum (HP:0000015)2.19625091
69Aplasia/hypoplasia of the humerus (HP:0006507)2.18774030
70Cerebral aneurysm (HP:0004944)2.17776268
71Selective tooth agenesis (HP:0001592)2.16099783
72Abnormal neuron morphology (HP:0012757)2.15151063
73Abnormality of the motor neurons (HP:0002450)2.15151063
74Turricephaly (HP:0000262)2.14162376
75Atrophic scars (HP:0001075)2.11902666
76Abnormal cartilage morphology (HP:0002763)2.10350210
77Disproportionate tall stature (HP:0001519)2.10039488
78Broad distal phalanx of finger (HP:0009836)2.09385593
79Abnormality of the calcaneus (HP:0008364)2.09310880
80Myokymia (HP:0002411)2.09028287
81Elfin facies (HP:0004428)2.08673678
82Nervous tissue neoplasm (HP:0030060)2.07717934
83Neuroectodermal neoplasm (HP:0030061)2.07717934
84Neuroepithelial neoplasm (HP:0030063)2.07717934
85Skin tags (HP:0010609)2.07680613
86Upper motor neuron abnormality (HP:0002127)2.06819656
87Bifid tongue (HP:0010297)2.06704370
88Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.05457128
89Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05269764
90Biconcave vertebral bodies (HP:0004586)2.03261680
91Increased nuchal translucency (HP:0010880)2.02736209
92Termporal pattern (HP:0011008)2.01724938
93Insidious onset (HP:0003587)2.01724938
94Shawl scrotum (HP:0000049)2.00753255
95Cerebral inclusion bodies (HP:0100314)1.98770355
96Neuroblastic tumors (HP:0004376)1.97931688
97Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.97931688
98Neuroblastoma (HP:0003006)1.97931688
99Primitive neuroectodermal tumor (HP:0030065)1.97931688
100Flat acetabular roof (HP:0003180)1.97582562
101Mitral regurgitation (HP:0001653)1.97438619
102Progressive muscle weakness (HP:0003323)1.96708291
103Wormian bones (HP:0002645)1.95581540
104Abnormality of chromosome segregation (HP:0002916)1.95541167
105Rectal fistula (HP:0100590)1.95429369
106Rectovaginal fistula (HP:0000143)1.95429369
107EMG: neuropathic changes (HP:0003445)1.94986698
108Fibroma (HP:0010614)1.94417241
109Hammertoe (HP:0001765)1.90932572
110Fasciculations (HP:0002380)1.90867964
111Medulloblastoma (HP:0002885)1.89792358
112Abnormality of skeletal muscle fiber size (HP:0012084)1.89257944
113Ankle contracture (HP:0006466)1.88734521
114Impaired pain sensation (HP:0007328)1.88729488
115Abnormality of pain sensation (HP:0010832)1.88729488
116Missing ribs (HP:0000921)1.88096169
117Lymphangioma (HP:0100764)1.87394097
118Abnormality of oral frenula (HP:0000190)1.84840217
119Abnormality of the distal phalanx of the thumb (HP:0009617)1.84653670
120Dysmetric saccades (HP:0000641)1.84578063
121Cervical subluxation (HP:0003308)1.84392699
122Patellar dislocation (HP:0002999)1.83969865
123Reticulocytosis (HP:0001923)1.82425487
124Abnormal lung lobation (HP:0002101)1.81923646
125Myopathic facies (HP:0002058)1.80603075
126Deviation of the thumb (HP:0009603)1.80194871
127Arnold-Chiari malformation (HP:0002308)1.79552431
128Vertebral arch anomaly (HP:0008438)1.79549696
129Apathy (HP:0000741)1.79322911
130Advanced eruption of teeth (HP:0006288)1.79175567
131Hyperventilation (HP:0002883)1.79082630
132Ankyloglossia (HP:0010296)1.78319728
133Vaginal fistula (HP:0004320)1.78195099
134Fibrous tissue neoplasm (HP:0012316)1.78068562
135Spastic tetraparesis (HP:0001285)1.78014873
136Abnormality of dentin (HP:0010299)1.76825072
137Spinal muscular atrophy (HP:0007269)1.76823449
138Renovascular hypertension (HP:0100817)1.76716680
139Short 5th finger (HP:0009237)1.76107725
140Obstructive sleep apnea (HP:0002870)1.76038269
141Elbow flexion contracture (HP:0002987)1.75982564
142Hyperinsulinemic hypoglycemia (HP:0000825)1.75754527
143Osteolytic defects of the hand bones (HP:0009699)1.75725043
144Osteolytic defects of the phalanges of the hand (HP:0009771)1.75725043
145Mildly elevated creatine phosphokinase (HP:0008180)1.75373601
146Natal tooth (HP:0000695)1.74850277
147Abnormality of the distal phalanges of the toes (HP:0010182)1.74152886
148Failure to thrive in infancy (HP:0001531)1.73365396
149Focal seizures (HP:0007359)1.73152785
150Partial duplication of thumb phalanx (HP:0009944)1.72715648
151Intellectual disability, profound (HP:0002187)1.72203683
152Thin bony cortex (HP:0002753)1.71974434
153Supranuclear gaze palsy (HP:0000605)1.71745403
154Intestinal fistula (HP:0100819)1.71527308
155Abnormality of the corticospinal tract (HP:0002492)1.69923561
156Glossoptosis (HP:0000162)1.69790541
157Supernumerary nipples (HP:0002558)1.69767402
158Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.69559784
159Aplasia/Hypoplasia of the sternum (HP:0006714)1.68992835
160Increased variability in muscle fiber diameter (HP:0003557)1.68980562
161Thin ribs (HP:0000883)1.68439076
162Distal sensory impairment (HP:0002936)1.68429666
163Hyperparathyroidism (HP:0000843)1.68289159
164Macroorchidism (HP:0000053)1.68227055
165Abnormality of the thoracic spine (HP:0100711)1.68174194
166Abnormality of the labia minora (HP:0012880)1.67629128
167Genu recurvatum (HP:0002816)1.67103699
168Proximal placement of thumb (HP:0009623)1.66967940
169Spinal cord lesions (HP:0100561)1.65889241
170Syringomyelia (HP:0003396)1.65889241
171Spinal cord compression (HP:0002176)1.65649357
172Premature skin wrinkling (HP:0100678)1.65442725
173Precocious puberty (HP:0000826)1.65421425
174Blue sclerae (HP:0000592)1.65133330
175Diminished motivation (HP:0000745)1.64881328
176Spastic diplegia (HP:0001264)1.64803684
177Bowel diverticulosis (HP:0005222)1.64361701
178Generalized amyotrophy (HP:0003700)1.63781720
179Exercise-induced myalgia (HP:0003738)1.63350944
180Aplasia involving bones of the extremities (HP:0009825)1.57757787
181Aplasia involving bones of the upper limbs (HP:0009823)1.57757787
182Aplasia of the phalanges of the hand (HP:0009802)1.57757787
183Stridor (HP:0010307)1.57641301
184Breech presentation (HP:0001623)1.57627936
185Flat cornea (HP:0007720)1.56361714
186Abnormality of the umbilical cord (HP:0010881)1.56205947

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.03962550
2GRK54.01465506
3SMG13.81380273
4ERN13.55864871
5GRK63.23720087
6TYRO32.76477099
7PRPF4B2.45325462
8MAP3K92.29205049
9NTRK12.24334104
10NEK12.19387813
11TRIB32.18753986
12NME22.08217185
13TTK1.93747650
14CSF1R1.89949038
15LATS21.89887946
16IRAK31.88202187
17ARAF1.78392094
18MATK1.77443263
19PAK41.64671412
20MAPK71.61081442
21ALK1.47502774
22MAP2K41.46711864
23PAK61.45826810
24PKN21.45004620
25NTRK31.44720521
26FGFR41.43457888
27SCYL21.43069759
28MAP3K101.42440075
29ADRBK21.37325723
30MOS1.36209219
31MST1R1.29301873
32WNK11.26776437
33MINK11.19925757
34CAMKK11.16465166
35GRK11.15554256
36KSR21.15217775
37EEF2K1.14583290
38CAMK41.13802313
39STK101.12197948
40MARK21.10499166
41PDGFRA1.07557382
42MARK11.05901792
43TESK21.05176275
44MET1.04635371
45CDC71.01360426
46PASK1.00496685
47PRKD30.98935027
48GRK70.97606011
49BUB10.95321007
50PLK10.95116044
51BRAF0.94777738
52MAP3K80.92431230
53PDK40.91285804
54PDK30.91285804
55EPHA40.89947683
56TGFBR20.89708039
57RIPK10.88886577
58PRKG20.88693513
59CDK150.88466387
60LMTK20.88352384
61TAOK20.87994203
62PBK0.86432312
63CDK180.86287141
64CDK70.86087377
65ADRBK10.83404578
66ICK0.79730755
67STK380.79651599
68DAPK20.77941632
69MAP3K40.77225217
70MAP3K130.77066155
71CDK11A0.76761322
72CDK140.76710709
73PTK60.75685373
74CHEK20.75539096
75NTRK20.75320551
76PAK20.75238294
77MTOR0.74402946
78RPS6KA20.73907095
79EPHA20.73871736
80AKT20.73857830
81FGFR30.72528051
82DAPK10.72198917
83BRSK10.71297996
84DDR20.70537208
85CHEK10.70089076
86NEK20.69942792
87TAOK10.69880176
88KSR10.69537719
89CAMK1D0.68685371
90MAP3K70.68306502
91PIM20.66512332
92BMX0.66109227
93MAPK110.65717508
94CDK40.63647608
95PTK20.62949022
96CDK60.61152790
97AKT30.59903071
98TTN0.58246054
99PAK30.57574453
100LRRK20.56519946
101PDPK10.55714747
102RET0.55541969
103PRKD20.55483309
104AURKA0.55091107
105UHMK10.54616343
106MAP2K20.54187330
107LIMK10.52220261
108MAPKAPK30.52159936
109MAP3K110.51765654
110RAF10.51429467
111CDK80.51049743
112PAK10.50991044
113HIPK20.50953143
114WEE10.50756305
115RPS6KB20.50747036
116DAPK30.50395348
117CDK90.50137401
118PRKCG0.50117397
119VRK20.49720635
120TSSK60.49233797
121ILK0.49181118
122MAP2K30.48839290
123* CDK20.48689094
124CSNK1E0.47600134
125LATS10.47396851
126SIK20.47340887
127MAP3K60.47215927
128EPHB20.46563401
129ERBB40.46308448
130CDK50.46122602
131PHKG20.44329132
132PHKG10.44329132
133ERBB20.43907397
134TESK10.43738830
135MAP3K10.43205847
136MAP2K60.43021738
137AURKB0.41758623
138PRKCI0.41349600
139ROCK20.40979610
140BRD40.40627554
141MAPK100.39877069
142SIK10.38703566
143MAPK120.36847326
144RPS6KL10.36173803
145RPS6KC10.36173803
146EPHB10.36025130
147CAMK2G0.34884619

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.75416906
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.32922560
3Fructose and mannose metabolism_Homo sapiens_hsa000512.85492398
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.47392059
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43492032
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.27624901
7mTOR signaling pathway_Homo sapiens_hsa041502.14458013
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08933809
9Synaptic vesicle cycle_Homo sapiens_hsa047212.05922481
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83539236
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80786290
12Galactose metabolism_Homo sapiens_hsa000521.79272159
13Central carbon metabolism in cancer_Homo sapiens_hsa052301.70257698
14RNA transport_Homo sapiens_hsa030131.53196758
15Biosynthesis of amino acids_Homo sapiens_hsa012301.50334499
16Thyroid cancer_Homo sapiens_hsa052161.48970246
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47936463
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.47343761
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42241970
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.40389807
21Carbon metabolism_Homo sapiens_hsa012001.35543318
22Long-term potentiation_Homo sapiens_hsa047201.34883793
23Oocyte meiosis_Homo sapiens_hsa041141.34307472
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33406262
25mRNA surveillance pathway_Homo sapiens_hsa030151.31742220
26Pancreatic cancer_Homo sapiens_hsa052121.30699543
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22456587
28Notch signaling pathway_Homo sapiens_hsa043301.22454371
29Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19605405
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19600869
31Focal adhesion_Homo sapiens_hsa045101.18527204
32Vibrio cholerae infection_Homo sapiens_hsa051101.18274774
33GABAergic synapse_Homo sapiens_hsa047271.17918564
34Glioma_Homo sapiens_hsa052141.16244562
35Non-small cell lung cancer_Homo sapiens_hsa052231.15188811
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14078945
37Base excision repair_Homo sapiens_hsa034101.13253457
38Small cell lung cancer_Homo sapiens_hsa052221.12433930
39Acute myeloid leukemia_Homo sapiens_hsa052211.12343329
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11081905
41Phospholipase D signaling pathway_Homo sapiens_hsa040721.10686227
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10179184
43Gap junction_Homo sapiens_hsa045401.09031760
44Adherens junction_Homo sapiens_hsa045201.07300028
45Sulfur relay system_Homo sapiens_hsa041221.04837857
46Olfactory transduction_Homo sapiens_hsa047401.04043395
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.02512367
48DNA replication_Homo sapiens_hsa030301.02381279
49Cell cycle_Homo sapiens_hsa041101.02366933
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99812791
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99616712
52Dopaminergic synapse_Homo sapiens_hsa047280.99106688
53GnRH signaling pathway_Homo sapiens_hsa049120.98666354
54Bladder cancer_Homo sapiens_hsa052190.97941147
55VEGF signaling pathway_Homo sapiens_hsa043700.97151782
56Other glycan degradation_Homo sapiens_hsa005110.96900624
57ECM-receptor interaction_Homo sapiens_hsa045120.96640524
58One carbon pool by folate_Homo sapiens_hsa006700.96179855
59Hedgehog signaling pathway_Homo sapiens_hsa043400.95148283
60Glutamatergic synapse_Homo sapiens_hsa047240.94254674
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91829936
62Renal cell carcinoma_Homo sapiens_hsa052110.91384317
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91169904
64Pentose phosphate pathway_Homo sapiens_hsa000300.88854573
65Hippo signaling pathway_Homo sapiens_hsa043900.87819737
66Oxytocin signaling pathway_Homo sapiens_hsa049210.85087027
67AMPK signaling pathway_Homo sapiens_hsa041520.84259657
68N-Glycan biosynthesis_Homo sapiens_hsa005100.83910038
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83685432
70Lysine degradation_Homo sapiens_hsa003100.83658296
71Nitrogen metabolism_Homo sapiens_hsa009100.82163129
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80921802
73Viral carcinogenesis_Homo sapiens_hsa052030.80294144
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79453510
75Colorectal cancer_Homo sapiens_hsa052100.79059431
76Rap1 signaling pathway_Homo sapiens_hsa040150.77498207
77Endometrial cancer_Homo sapiens_hsa052130.77243686
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77038411
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76260713
80Basal cell carcinoma_Homo sapiens_hsa052170.76259833
81Prostate cancer_Homo sapiens_hsa052150.75642325
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75537436
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.75395389
84Proteoglycans in cancer_Homo sapiens_hsa052050.75079471
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74215114
86Arginine biosynthesis_Homo sapiens_hsa002200.74176309
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72570916
88Long-term depression_Homo sapiens_hsa047300.71749539
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70943499
90Mismatch repair_Homo sapiens_hsa034300.70735619
91Shigellosis_Homo sapiens_hsa051310.70484825
92Circadian entrainment_Homo sapiens_hsa047130.70318744
93MicroRNAs in cancer_Homo sapiens_hsa052060.69696877
94Inositol phosphate metabolism_Homo sapiens_hsa005620.69141833
95ErbB signaling pathway_Homo sapiens_hsa040120.64103563
96Insulin signaling pathway_Homo sapiens_hsa049100.63617734
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.62813407
98Salivary secretion_Homo sapiens_hsa049700.62172789
99Spliceosome_Homo sapiens_hsa030400.61572510
100Amphetamine addiction_Homo sapiens_hsa050310.61480365
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60813534
102Estrogen signaling pathway_Homo sapiens_hsa049150.60454512
103Dilated cardiomyopathy_Homo sapiens_hsa054140.59832308
104Amoebiasis_Homo sapiens_hsa051460.59193137
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.58889994
106Apoptosis_Homo sapiens_hsa042100.58824960
107Choline metabolism in cancer_Homo sapiens_hsa052310.58485657
108Melanoma_Homo sapiens_hsa052180.57336077
109Tight junction_Homo sapiens_hsa045300.56397248
110Nicotine addiction_Homo sapiens_hsa050330.55915514
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55476393
112Arginine and proline metabolism_Homo sapiens_hsa003300.54164046
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53839325
114Axon guidance_Homo sapiens_hsa043600.51734557
115Endocytosis_Homo sapiens_hsa041440.51702173
116Gastric acid secretion_Homo sapiens_hsa049710.50935392
117Taste transduction_Homo sapiens_hsa047420.50900905
118Melanogenesis_Homo sapiens_hsa049160.50325367
119Pyruvate metabolism_Homo sapiens_hsa006200.49283253
120Hepatitis B_Homo sapiens_hsa051610.48699528
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48306587
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48181334
123Pathways in cancer_Homo sapiens_hsa052000.47569843
124cAMP signaling pathway_Homo sapiens_hsa040240.47359105
125Calcium signaling pathway_Homo sapiens_hsa040200.47297628
126Alcoholism_Homo sapiens_hsa050340.47291282
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47160182
128Dorso-ventral axis formation_Homo sapiens_hsa043200.46690472
129Cholinergic synapse_Homo sapiens_hsa047250.46437218
130Wnt signaling pathway_Homo sapiens_hsa043100.44250326
131Glucagon signaling pathway_Homo sapiens_hsa049220.43894566
132HIF-1 signaling pathway_Homo sapiens_hsa040660.42164994
133Prion diseases_Homo sapiens_hsa050200.41146886
134Bile secretion_Homo sapiens_hsa049760.40121119
135Chronic myeloid leukemia_Homo sapiens_hsa052200.39344671

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