

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.91889709 |
| 2 | ATP synthesis coupled proton transport (GO:0015986) | 7.44189008 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 7.44189008 |
| 4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 6.96958154 |
| 5 | ribosomal small subunit biogenesis (GO:0042274) | 6.75542092 |
| 6 | regulation of meiosis I (GO:0060631) | 6.10603722 |
| 7 | respiratory electron transport chain (GO:0022904) | 6.07739826 |
| 8 | behavioral response to nicotine (GO:0035095) | 6.06009318 |
| 9 | viral transcription (GO:0019083) | 5.95868153 |
| 10 | electron transport chain (GO:0022900) | 5.93254173 |
| 11 | translational termination (GO:0006415) | 5.74331033 |
| 12 | chaperone-mediated protein transport (GO:0072321) | 5.73119873 |
| 13 | protein neddylation (GO:0045116) | 5.41928049 |
| 14 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.39209311 |
| 15 | proteasome assembly (GO:0043248) | 5.26778200 |
| 16 | cotranslational protein targeting to membrane (GO:0006613) | 5.20020565 |
| 17 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 5.18484512 |
| 18 | termination of RNA polymerase III transcription (GO:0006386) | 5.18484512 |
| 19 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.17279218 |
| 20 | protein targeting to ER (GO:0045047) | 5.11936951 |
| 21 | maturation of SSU-rRNA (GO:0030490) | 5.08791312 |
| 22 | ribosomal small subunit assembly (GO:0000028) | 5.00248896 |
| 23 | protein localization to endoplasmic reticulum (GO:0070972) | 4.90773165 |
| 24 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.87761600 |
| 25 | piRNA metabolic process (GO:0034587) | 4.85804500 |
| 26 | translational elongation (GO:0006414) | 4.85708547 |
| 27 | GTP biosynthetic process (GO:0006183) | 4.70917818 |
| 28 | cellular protein complex disassembly (GO:0043624) | 4.65591217 |
| 29 | protein complex biogenesis (GO:0070271) | 4.57793970 |
| 30 | regulation of female gonad development (GO:2000194) | 4.55928898 |
| 31 | viral life cycle (GO:0019058) | 4.55465959 |
| 32 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.51246272 |
| 33 | NADH dehydrogenase complex assembly (GO:0010257) | 4.51246272 |
| 34 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.51246272 |
| 35 | DNA deamination (GO:0045006) | 4.48042187 |
| 36 | 7-methylguanosine mRNA capping (GO:0006370) | 4.46779686 |
| 37 | ribosomal large subunit biogenesis (GO:0042273) | 4.45392540 |
| 38 | platelet dense granule organization (GO:0060155) | 4.44648373 |
| 39 | translational initiation (GO:0006413) | 4.42118268 |
| 40 | RNA capping (GO:0036260) | 4.39566450 |
| 41 | 7-methylguanosine RNA capping (GO:0009452) | 4.39566450 |
| 42 | regulation of mitochondrial translation (GO:0070129) | 4.36559709 |
| 43 | translation (GO:0006412) | 4.32678626 |
| 44 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.27467423 |
| 45 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.21085150 |
| 46 | UTP biosynthetic process (GO:0006228) | 4.11787178 |
| 47 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 4.00696849 |
| 48 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.00175938 |
| 49 | protein targeting to mitochondrion (GO:0006626) | 3.99206999 |
| 50 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.98118387 |
| 51 | establishment of protein localization to mitochondrion (GO:0072655) | 3.97793927 |
| 52 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.94436139 |
| 53 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.94408893 |
| 54 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.90259383 |
| 55 | cellular component biogenesis (GO:0044085) | 3.89298755 |
| 56 | DNA methylation involved in gamete generation (GO:0043046) | 3.89216058 |
| 57 | protein complex disassembly (GO:0043241) | 3.88272509 |
| 58 | DNA double-strand break processing (GO:0000729) | 3.87078939 |
| 59 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.84891452 |
| 60 | establishment of integrated proviral latency (GO:0075713) | 3.81057634 |
| 61 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.74729879 |
| 62 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.72735637 |
| 63 | negative regulation of ligase activity (GO:0051352) | 3.72735637 |
| 64 | macromolecular complex disassembly (GO:0032984) | 3.72664195 |
| 65 | ATP biosynthetic process (GO:0006754) | 3.72549201 |
| 66 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.69747260 |
| 67 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.69747260 |
| 68 | hydrogen ion transmembrane transport (GO:1902600) | 3.69089659 |
| 69 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.68047573 |
| 70 | positive regulation of histone H3-K4 methylation (GO:0051571) | 3.67305885 |
| 71 | protein localization to mitochondrion (GO:0070585) | 3.66026395 |
| 72 | response to pheromone (GO:0019236) | 3.66000334 |
| 73 | neurofilament cytoskeleton organization (GO:0060052) | 3.61315111 |
| 74 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.60884191 |
| 75 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.59535596 |
| 76 | transcription from RNA polymerase I promoter (GO:0006360) | 3.56628053 |
| 77 | multicellular organism reproduction (GO:0032504) | 3.54910308 |
| 78 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.53822661 |
| 79 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.52719617 |
| 80 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.52719617 |
| 81 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.52719617 |
| 82 | rRNA modification (GO:0000154) | 3.52547334 |
| 83 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.51437240 |
| 84 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.51437240 |
| 85 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.50237549 |
| 86 | UTP metabolic process (GO:0046051) | 3.48190496 |
| 87 | termination of RNA polymerase I transcription (GO:0006363) | 3.48137706 |
| 88 | synaptic transmission, cholinergic (GO:0007271) | 3.47785646 |
| 89 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.46887313 |
| 90 | rRNA processing (GO:0006364) | 3.46027543 |
| 91 | spliceosomal snRNP assembly (GO:0000387) | 3.45839339 |
| 92 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.44472614 |
| 93 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.44472614 |
| 94 | protein-cofactor linkage (GO:0018065) | 3.43912527 |
| 95 | protein localization to cilium (GO:0061512) | 3.43586659 |
| 96 | respiratory chain complex IV assembly (GO:0008535) | 3.41750378 |
| 97 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.40719426 |
| 98 | protein targeting to membrane (GO:0006612) | 3.40051980 |
| 99 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.38018967 |
| 100 | peptidyl-histidine modification (GO:0018202) | 3.35834865 |
| 101 | nucleobase catabolic process (GO:0046113) | 3.35195065 |
| 102 | inner mitochondrial membrane organization (GO:0007007) | 3.35124735 |
| 103 | establishment of viral latency (GO:0019043) | 3.33891172 |
| 104 | norepinephrine metabolic process (GO:0042415) | 3.33382159 |
| 105 | cullin deneddylation (GO:0010388) | 3.32463403 |
| 106 | CTP metabolic process (GO:0046036) | 3.32298189 |
| 107 | CTP biosynthetic process (GO:0006241) | 3.32298189 |
| 108 | rRNA metabolic process (GO:0016072) | 3.30931036 |
| 109 | dopamine transport (GO:0015872) | 3.29483287 |
| 110 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.29074628 |
| 111 | detection of light stimulus involved in visual perception (GO:0050908) | 3.26523516 |
| 112 | detection of light stimulus involved in sensory perception (GO:0050962) | 3.26523516 |
| 113 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.24455667 |
| 114 | proton transport (GO:0015992) | 3.23115505 |
| 115 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.21427466 |
| 116 | positive regulation of meiosis (GO:0045836) | 3.20544403 |
| 117 | spliceosomal complex assembly (GO:0000245) | 3.19809188 |
| 118 | oxidative phosphorylation (GO:0006119) | 3.16741127 |
| 119 | hydrogen transport (GO:0006818) | 3.15081965 |
| 120 | protein deneddylation (GO:0000338) | 3.13101435 |
| 121 | positive regulation of ligase activity (GO:0051351) | 3.11726184 |
| 122 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.11291654 |
| 123 | nonmotile primary cilium assembly (GO:0035058) | 3.09147331 |
| 124 | retinal cone cell development (GO:0046549) | 3.08593911 |
| 125 | protein prenylation (GO:0018342) | 3.07182127 |
| 126 | prenylation (GO:0097354) | 3.07182127 |
| 127 | cellular ketone body metabolic process (GO:0046950) | 3.06852562 |
| 128 | ketone body metabolic process (GO:1902224) | 3.06248048 |
| 129 | meiotic cell cycle (GO:0051321) | 3.05248731 |
| 130 | ubiquinone biosynthetic process (GO:0006744) | 3.01696632 |
| 131 | photoreceptor cell maintenance (GO:0045494) | 2.97439407 |
| 132 | positive regulation of meiotic cell cycle (GO:0051446) | 2.97150424 |
| 133 | alanine transport (GO:0032328) | 2.93703396 |
| 134 | negative regulation of telomere maintenance (GO:0032205) | 2.92700206 |
| 135 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.91502115 |
| 136 | axoneme assembly (GO:0035082) | 2.87325520 |
| 137 | epithelial cilium movement (GO:0003351) | 2.87172260 |
| 138 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.84146004 |
| 139 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.84146004 |
| 140 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.83934034 |
| 141 | serotonin metabolic process (GO:0042428) | 2.82425327 |
| 142 | female gamete generation (GO:0007292) | 2.81620199 |
| 143 | phosphorylated carbohydrate dephosphorylation (GO:0046838) | 2.81534179 |
| 144 | inositol phosphate dephosphorylation (GO:0046855) | 2.81534179 |
| 145 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.78446017 |
| 146 | L-fucose catabolic process (GO:0042355) | 2.77311218 |
| 147 | fucose catabolic process (GO:0019317) | 2.77311218 |
| 148 | L-fucose metabolic process (GO:0042354) | 2.77311218 |
| 149 | inositol phosphate catabolic process (GO:0071545) | 2.75748559 |
| 150 | primary amino compound metabolic process (GO:1901160) | 2.74882915 |
| 151 | intraciliary transport (GO:0042073) | 2.74673205 |
| 152 | ubiquinone metabolic process (GO:0006743) | 2.72293527 |
| 153 | mismatch repair (GO:0006298) | 2.71568403 |
| 154 | cornea development in camera-type eye (GO:0061303) | 2.70629947 |
| 155 | maturation of 5.8S rRNA (GO:0000460) | 2.70339185 |
| 156 | phosphorelay signal transduction system (GO:0000160) | 2.70301292 |
| 157 | recombinational repair (GO:0000725) | 2.64830781 |
| 158 | regulation of DNA methylation (GO:0044030) | 2.64482612 |
| 159 | centriole replication (GO:0007099) | 2.64443953 |
| 160 | double-strand break repair via homologous recombination (GO:0000724) | 2.64393249 |
| 161 | quinone biosynthetic process (GO:1901663) | 2.63149447 |
| 162 | photoreceptor cell development (GO:0042461) | 2.61345043 |
| 163 | regulation of action potential (GO:0098900) | 2.60836648 |
| 164 | transmission of nerve impulse (GO:0019226) | 2.59231835 |
| 165 | cilium or flagellum-dependent cell motility (GO:0001539) | 2.55181110 |
| 166 | relaxation of smooth muscle (GO:0044557) | 2.53044023 |
| 167 | regulation of acrosome reaction (GO:0060046) | 2.52913707 |
| 168 | proline transport (GO:0015824) | 2.51357410 |
| 169 | catechol-containing compound biosynthetic process (GO:0009713) | 2.50399948 |
| 170 | catecholamine biosynthetic process (GO:0042423) | 2.50399948 |
| 171 | C4-dicarboxylate transport (GO:0015740) | 2.49091197 |
| 172 | synapsis (GO:0007129) | 2.48483377 |
| 173 | DNA replication checkpoint (GO:0000076) | 2.46553194 |
| 174 | DNA damage response, detection of DNA damage (GO:0042769) | 2.46492694 |
| 175 | sperm motility (GO:0030317) | 2.44811783 |
| 176 | regulation of oxidative phosphorylation (GO:0002082) | 2.43971572 |
| 177 | cAMP catabolic process (GO:0006198) | 2.43061866 |
| 178 | cilium movement (GO:0003341) | 2.42799526 |
| 179 | serotonin receptor signaling pathway (GO:0007210) | 2.42762691 |
| 180 | regulation of cilium movement (GO:0003352) | 2.42331478 |
| 181 | cytochrome complex assembly (GO:0017004) | 2.41823380 |
| 182 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 2.41200107 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 5.27990490 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.99442891 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.69789685 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.44616671 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.28976950 |
| 6 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 4.24229099 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.13113354 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.88385357 |
| 9 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.82854530 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.44884437 |
| 11 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.35710882 |
| 12 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.30370966 |
| 13 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.28790186 |
| 14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.17578431 |
| 15 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.10646904 |
| 16 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.92201763 |
| 17 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.85322505 |
| 18 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.74481615 |
| 19 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.52813060 |
| 20 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.51360773 |
| 21 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.49654947 |
| 22 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.45635661 |
| 23 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.36284424 |
| 24 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.26200521 |
| 25 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.25933187 |
| 26 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.21361121 |
| 27 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.20049798 |
| 28 | * ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.19520297 |
| 29 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.18187858 |
| 30 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.17346918 |
| 31 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.10901985 |
| 32 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.06120332 |
| 33 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.05586288 |
| 34 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.02447175 |
| 35 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.01733218 |
| 36 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.97782778 |
| 37 | EWS_26573619_Chip-Seq_HEK293_Human | 1.97752394 |
| 38 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.93566802 |
| 39 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.92704211 |
| 40 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.91794968 |
| 41 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.90649727 |
| 42 | P300_19829295_ChIP-Seq_ESCs_Human | 1.87330589 |
| 43 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.82953805 |
| 44 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.76465788 |
| 45 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.76270903 |
| 46 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.74768538 |
| 47 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.73811243 |
| 48 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.73811243 |
| 49 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.73748810 |
| 50 | * AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.72904091 |
| 51 | AR_25329375_ChIP-Seq_VCAP_Human | 1.72642239 |
| 52 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.72417587 |
| 53 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.72417587 |
| 54 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.71360834 |
| 55 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.70456320 |
| 56 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.68046650 |
| 57 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.67207209 |
| 58 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.62233578 |
| 59 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.62098808 |
| 60 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.58930282 |
| 61 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.58029577 |
| 62 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.57660066 |
| 63 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.56412575 |
| 64 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.53118985 |
| 65 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.49963872 |
| 66 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.49072834 |
| 67 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.47899052 |
| 68 | * ER_23166858_ChIP-Seq_MCF-7_Human | 1.47520209 |
| 69 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.46048579 |
| 70 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.46048579 |
| 71 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.41029931 |
| 72 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.40647129 |
| 73 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.40282918 |
| 74 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.40220183 |
| 75 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.40170154 |
| 76 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.39058428 |
| 77 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.37626146 |
| 78 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.37549440 |
| 79 | * TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.37369248 |
| 80 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.37357000 |
| 81 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.35589330 |
| 82 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.35297316 |
| 83 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.35297316 |
| 84 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.34677139 |
| 85 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.34577816 |
| 86 | VDR_22108803_ChIP-Seq_LS180_Human | 1.33426287 |
| 87 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.33315866 |
| 88 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.32742739 |
| 89 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.32491931 |
| 90 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.30075603 |
| 91 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.29802266 |
| 92 | STAT3_23295773_ChIP-Seq_U87_Human | 1.29734591 |
| 93 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.27838374 |
| 94 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.27418870 |
| 95 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.27250386 |
| 96 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.26847380 |
| 97 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.26375385 |
| 98 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.25151676 |
| 99 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.24719852 |
| 100 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.23359637 |
| 101 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.21439928 |
| 102 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.20970864 |
| 103 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.20580137 |
| 104 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.16402349 |
| 105 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.15601710 |
| 106 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.14330827 |
| 107 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.13997649 |
| 108 | NCOR_22424771_ChIP-Seq_293T_Human | 1.13629877 |
| 109 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.13173491 |
| 110 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.12779130 |
| 111 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.12720859 |
| 112 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.11527083 |
| 113 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.10980405 |
| 114 | JUN_21703547_ChIP-Seq_K562_Human | 1.09418073 |
| 115 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.09416241 |
| 116 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.08620772 |
| 117 | * TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.07521903 |
| 118 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.07517895 |
| 119 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 1.07508377 |
| 120 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.07249584 |
| 121 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.06731966 |
| 122 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.06702842 |
| 123 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.06005866 |
| 124 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.05409665 |
| 125 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.05308059 |
| 126 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.04940914 |
| 127 | * STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.04834515 |
| 128 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.04420290 |
| 129 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.01859566 |
| 130 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.01682125 |
| 131 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.01280781 |
| 132 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.99562418 |
| 133 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.99057956 |
| 134 | * NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.98903290 |
| 135 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.98875285 |
| 136 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 0.98385057 |
| 137 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.97549315 |
| 138 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.97364963 |
| 139 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.97288962 |
| 140 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.97224581 |
| 141 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.96885756 |
| 142 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.96279728 |
| 143 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.95393907 |
| 144 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.94324293 |
| 145 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.91966474 |
| 146 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.91666507 |
| 147 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.91180919 |
| 148 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.91062193 |
| 149 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.90049151 |
| 150 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.89564863 |
| 151 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.88368531 |
| 152 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.87566399 |
| 153 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.87510111 |
| 154 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.85530849 |
| 155 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.85448865 |
| 156 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.84994649 |
| 157 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.84041020 |
| 158 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.82633605 |
| 159 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.80069786 |
| 160 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.78958182 |
| 161 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.77533821 |
| 162 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.77260545 |
| 163 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.76003895 |
| 164 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.75153123 |
| 165 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.74308310 |
| 166 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.72724185 |
| 167 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.72568288 |
| 168 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.72271461 |
| 169 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.70974236 |
| 170 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.70404269 |
| 171 | FUS_26573619_Chip-Seq_HEK293_Human | 0.68918798 |
| 172 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.68560879 |
| 173 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.66497094 |
| 174 | E2F7_22180533_ChIP-Seq_HELA_Human | 0.64757754 |
| 175 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.64238911 |
| 176 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.64215178 |
| 177 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.64012961 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009379_abnormal_foot_pigmentation | 4.87984768 |
| 2 | MP0001529_abnormal_vocalization | 4.01474466 |
| 3 | MP0003880_abnormal_central_pattern | 3.73853767 |
| 4 | MP0002138_abnormal_hepatobiliary_system | 3.15045540 |
| 5 | MP0001905_abnormal_dopamine_level | 3.10164944 |
| 6 | MP0006276_abnormal_autonomic_nervous | 2.88068945 |
| 7 | MP0003693_abnormal_embryo_hatching | 2.87771751 |
| 8 | MP0009697_abnormal_copulation | 2.78182202 |
| 9 | MP0003136_yellow_coat_color | 2.63042615 |
| 10 | MP0000569_abnormal_digit_pigmentation | 2.58482644 |
| 11 | MP0003718_maternal_effect | 2.57136826 |
| 12 | MP0003787_abnormal_imprinting | 2.50999398 |
| 13 | MP0003195_calcinosis | 2.37055127 |
| 14 | MP0003121_genomic_imprinting | 2.24356132 |
| 15 | MP0006036_abnormal_mitochondrial_physio | 2.23744484 |
| 16 | MP0004147_increased_porphyrin_level | 2.23146579 |
| 17 | MP0002653_abnormal_ependyma_morphology | 2.13897561 |
| 18 | MP0006292_abnormal_olfactory_placode | 2.12602953 |
| 19 | MP0004957_abnormal_blastocyst_morpholog | 2.08210703 |
| 20 | MP0008932_abnormal_embryonic_tissue | 2.06007535 |
| 21 | MP0005551_abnormal_eye_electrophysiolog | 2.04379280 |
| 22 | MP0002837_dystrophic_cardiac_calcinosis | 2.03849285 |
| 23 | MP0005646_abnormal_pituitary_gland | 2.03405886 |
| 24 | MP0006035_abnormal_mitochondrial_morpho | 1.98114513 |
| 25 | MP0005410_abnormal_fertilization | 1.97140920 |
| 26 | MP0001986_abnormal_taste_sensitivity | 1.92355271 |
| 27 | MP0002638_abnormal_pupillary_reflex | 1.90740093 |
| 28 | MP0003786_premature_aging | 1.82932557 |
| 29 | MP0001188_hyperpigmentation | 1.75346070 |
| 30 | MP0008058_abnormal_DNA_repair | 1.73876880 |
| 31 | MP0008057_abnormal_DNA_replication | 1.72432403 |
| 32 | MP0005645_abnormal_hypothalamus_physiol | 1.72322571 |
| 33 | MP0004142_abnormal_muscle_tone | 1.70865496 |
| 34 | MP0002163_abnormal_gland_morphology | 1.65216554 |
| 35 | MP0005409_darkened_coat_color | 1.61674675 |
| 36 | MP0002736_abnormal_nociception_after | 1.58803888 |
| 37 | MP0005423_abnormal_somatic_nervous | 1.55763525 |
| 38 | MP0004381_abnormal_hair_follicle | 1.55188840 |
| 39 | MP0002102_abnormal_ear_morphology | 1.55116713 |
| 40 | MP0003186_abnormal_redox_activity | 1.54103552 |
| 41 | MP0005499_abnormal_olfactory_system | 1.52588540 |
| 42 | MP0005394_taste/olfaction_phenotype | 1.52588540 |
| 43 | MP0003283_abnormal_digestive_organ | 1.52275338 |
| 44 | MP0001968_abnormal_touch/_nociception | 1.49827319 |
| 45 | MP0001727_abnormal_embryo_implantation | 1.47974882 |
| 46 | MP0003646_muscle_fatigue | 1.47565261 |
| 47 | MP0003123_paternal_imprinting | 1.47497970 |
| 48 | MP0002938_white_spotting | 1.45892569 |
| 49 | MP0003315_abnormal_perineum_morphology | 1.45687080 |
| 50 | MP0000372_irregular_coat_pigmentation | 1.43884779 |
| 51 | MP0002735_abnormal_chemical_nociception | 1.41208490 |
| 52 | MP0003077_abnormal_cell_cycle | 1.39739902 |
| 53 | MP0000566_synostosis | 1.37930954 |
| 54 | MP0005379_endocrine/exocrine_gland_phen | 1.36632559 |
| 55 | MP0005253_abnormal_eye_physiology | 1.35969781 |
| 56 | MP0004145_abnormal_muscle_electrophysio | 1.35758673 |
| 57 | MP0001440_abnormal_grooming_behavior | 1.34259016 |
| 58 | MP0005171_absent_coat_pigmentation | 1.33565081 |
| 59 | MP0001324_abnormal_eye_pigmentation | 1.31701792 |
| 60 | MP0000631_abnormal_neuroendocrine_gland | 1.29621966 |
| 61 | MP0003941_abnormal_skin_development | 1.25646829 |
| 62 | MP0002132_abnormal_respiratory_system | 1.24653790 |
| 63 | MP0002751_abnormal_autonomic_nervous | 1.24540308 |
| 64 | MP0000750_abnormal_muscle_regeneration | 1.23321795 |
| 65 | MP0002734_abnormal_mechanical_nocicepti | 1.22966694 |
| 66 | MP0010094_abnormal_chromosome_stability | 1.22433930 |
| 67 | MP0003111_abnormal_nucleus_morphology | 1.21675424 |
| 68 | MP0002160_abnormal_reproductive_system | 1.20265173 |
| 69 | MP0005075_abnormal_melanosome_morpholog | 1.19487984 |
| 70 | MP0003938_abnormal_ear_development | 1.17941593 |
| 71 | MP0002277_abnormal_respiratory_mucosa | 1.16731733 |
| 72 | MP0002272_abnormal_nervous_system | 1.15907840 |
| 73 | MP0001970_abnormal_pain_threshold | 1.15739270 |
| 74 | MP0008872_abnormal_physiological_respon | 1.14057514 |
| 75 | MP0004885_abnormal_endolymph | 1.13275209 |
| 76 | MP0003122_maternal_imprinting | 1.13100490 |
| 77 | MP0005408_hypopigmentation | 1.10237996 |
| 78 | MP0004742_abnormal_vestibular_system | 1.08937873 |
| 79 | MP0003635_abnormal_synaptic_transmissio | 1.06379726 |
| 80 | MP0002557_abnormal_social/conspecific_i | 1.05776541 |
| 81 | MP0008995_early_reproductive_senescence | 1.03592303 |
| 82 | MP0000427_abnormal_hair_cycle | 1.03205714 |
| 83 | MP0002095_abnormal_skin_pigmentation | 1.02163740 |
| 84 | MP0004043_abnormal_pH_regulation | 1.01813660 |
| 85 | MP0003806_abnormal_nucleotide_metabolis | 1.01550242 |
| 86 | MP0006072_abnormal_retinal_apoptosis | 1.00277642 |
| 87 | MP0005195_abnormal_posterior_eye | 1.00033357 |
| 88 | MP0008789_abnormal_olfactory_epithelium | 0.99830912 |
| 89 | MP0005389_reproductive_system_phenotype | 0.98763717 |
| 90 | MP0005167_abnormal_blood-brain_barrier | 0.97255494 |
| 91 | MP0002210_abnormal_sex_determination | 0.95829742 |
| 92 | MP0003698_abnormal_male_reproductive | 0.95629794 |
| 93 | MP0010386_abnormal_urinary_bladder | 0.94990742 |
| 94 | MP0001929_abnormal_gametogenesis | 0.94917254 |
| 95 | MP0000749_muscle_degeneration | 0.94739666 |
| 96 | MP0005174_abnormal_tail_pigmentation | 0.94591408 |
| 97 | MP0008260_abnormal_autophagy | 0.94245885 |
| 98 | MP0002876_abnormal_thyroid_physiology | 0.93892363 |
| 99 | MP0002063_abnormal_learning/memory/cond | 0.93852573 |
| 100 | MP0002733_abnormal_thermal_nociception | 0.93265296 |
| 101 | MP0004133_heterotaxia | 0.93262493 |
| 102 | MP0001485_abnormal_pinna_reflex | 0.91970763 |
| 103 | MP0000015_abnormal_ear_pigmentation | 0.91875634 |
| 104 | MP0002184_abnormal_innervation | 0.90525693 |
| 105 | MP0009745_abnormal_behavioral_response | 0.90446326 |
| 106 | MP0008875_abnormal_xenobiotic_pharmacok | 0.90216966 |
| 107 | MP0003137_abnormal_impulse_conducting | 0.89759302 |
| 108 | MP0001661_extended_life_span | 0.89478852 |
| 109 | MP0003011_delayed_dark_adaptation | 0.89306637 |
| 110 | MP0002752_abnormal_somatic_nervous | 0.88549270 |
| 111 | MP0005085_abnormal_gallbladder_physiolo | 0.88044881 |
| 112 | MP0006054_spinal_hemorrhage | 0.87335926 |
| 113 | MP0005451_abnormal_body_composition | 0.86814912 |
| 114 | MP0001984_abnormal_olfaction | 0.85886626 |
| 115 | MP0005395_other_phenotype | 0.85516292 |
| 116 | MP0001293_anophthalmia | 0.84841366 |
| 117 | MP0000358_abnormal_cell_content/ | 0.84159271 |
| 118 | MP0002064_seizures | 0.83753174 |
| 119 | MP0000778_abnormal_nervous_system | 0.83385875 |
| 120 | MP0002229_neurodegeneration | 0.82938610 |
| 121 | MP0005503_abnormal_tendon_morphology | 0.82587773 |
| 122 | MP0001542_abnormal_bone_strength | 0.82513407 |
| 123 | MP0003890_abnormal_embryonic-extraembry | 0.81718667 |
| 124 | MP0004924_abnormal_behavior | 0.81341888 |
| 125 | MP0005386_behavior/neurological_phenoty | 0.81341888 |
| 126 | MP0005636_abnormal_mineral_homeostasis | 0.81295318 |
| 127 | MP0004215_abnormal_myocardial_fiber | 0.80221427 |
| 128 | MP0002572_abnormal_emotion/affect_behav | 0.79740473 |
| 129 | MP0000026_abnormal_inner_ear | 0.78696453 |
| 130 | MP0005084_abnormal_gallbladder_morpholo | 0.78528045 |
| 131 | MP0001145_abnormal_male_reproductive | 0.77617659 |
| 132 | MP0002067_abnormal_sensory_capabilities | 0.77023671 |
| 133 | MP0008877_abnormal_DNA_methylation | 0.76667580 |
| 134 | MP0009046_muscle_twitch | 0.75796601 |
| 135 | MP0000371_diluted_coat_color | 0.75186927 |
| 136 | MP0001501_abnormal_sleep_pattern | 0.73675154 |
| 137 | MP0005332_abnormal_amino_acid | 0.72604446 |
| 138 | MP0001764_abnormal_homeostasis | 0.72200200 |
| 139 | MP0001486_abnormal_startle_reflex | 0.71415583 |
| 140 | MP0003950_abnormal_plasma_membrane | 0.70690048 |
| 141 | MP0000653_abnormal_sex_gland | 0.69666197 |
| 142 | MP0001963_abnormal_hearing_physiology | 0.69497016 |
| 143 | MP0000751_myopathy | 0.68481146 |
| 144 | MP0009333_abnormal_splenocyte_physiolog | 0.67541584 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 6.78094788 |
| 2 | Mitochondrial inheritance (HP:0001427) | 6.05342451 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.98026614 |
| 4 | Progressive macrocephaly (HP:0004481) | 5.55540193 |
| 5 | Acute encephalopathy (HP:0006846) | 5.39380326 |
| 6 | Hepatocellular necrosis (HP:0001404) | 5.17955007 |
| 7 | Increased CSF lactate (HP:0002490) | 5.12502759 |
| 8 | Increased hepatocellular lipid droplets (HP:0006565) | 5.08101961 |
| 9 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.01170516 |
| 10 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 4.61833773 |
| 11 | Lipid accumulation in hepatocytes (HP:0006561) | 4.45790006 |
| 12 | Abnormal number of erythroid precursors (HP:0012131) | 4.43329948 |
| 13 | Hepatic necrosis (HP:0002605) | 4.38895576 |
| 14 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 4.34857088 |
| 15 | Renal Fanconi syndrome (HP:0001994) | 4.32169799 |
| 16 | 3-Methylglutaconic aciduria (HP:0003535) | 4.20233118 |
| 17 | Pancreatic cysts (HP:0001737) | 4.10932903 |
| 18 | Reticulocytopenia (HP:0001896) | 3.98281671 |
| 19 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.88693629 |
| 20 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.88693629 |
| 21 | True hermaphroditism (HP:0010459) | 3.70731141 |
| 22 | Cerebral edema (HP:0002181) | 3.69628078 |
| 23 | Increased intramyocellular lipid droplets (HP:0012240) | 3.64147290 |
| 24 | Exercise intolerance (HP:0003546) | 3.62627387 |
| 25 | Exertional dyspnea (HP:0002875) | 3.62268172 |
| 26 | Congenital stationary night blindness (HP:0007642) | 3.61118506 |
| 27 | Optic disc pallor (HP:0000543) | 3.55749487 |
| 28 | Macrocytic anemia (HP:0001972) | 3.51505917 |
| 29 | Respiratory failure (HP:0002878) | 3.51205970 |
| 30 | Increased serum lactate (HP:0002151) | 3.37802761 |
| 31 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.37660937 |
| 32 | Abnormality of midbrain morphology (HP:0002418) | 3.35184967 |
| 33 | Molar tooth sign on MRI (HP:0002419) | 3.35184967 |
| 34 | Lactic acidosis (HP:0003128) | 3.34534495 |
| 35 | Leukodystrophy (HP:0002415) | 3.26659473 |
| 36 | Respiratory difficulties (HP:0002880) | 3.09857925 |
| 37 | Abnormality of glycolysis (HP:0004366) | 3.06318016 |
| 38 | Increased serum pyruvate (HP:0003542) | 3.06318016 |
| 39 | Increased muscle lipid content (HP:0009058) | 3.02087542 |
| 40 | Ulnar claw (HP:0001178) | 2.97376325 |
| 41 | Pallor (HP:0000980) | 2.89776971 |
| 42 | Cerebral hypomyelination (HP:0006808) | 2.84068031 |
| 43 | Methylmalonic acidemia (HP:0002912) | 2.83853884 |
| 44 | Nephronophthisis (HP:0000090) | 2.83539952 |
| 45 | Abnormality of renal resorption (HP:0011038) | 2.79369579 |
| 46 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.70395995 |
| 47 | Hypoplasia of the fovea (HP:0007750) | 2.70395995 |
| 48 | Hypoglycemic seizures (HP:0002173) | 2.67989663 |
| 49 | Parakeratosis (HP:0001036) | 2.64757908 |
| 50 | Cystic liver disease (HP:0006706) | 2.64497421 |
| 51 | Abnormality of the fovea (HP:0000493) | 2.64124143 |
| 52 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.59950345 |
| 53 | CNS demyelination (HP:0007305) | 2.59798497 |
| 54 | Gait imbalance (HP:0002141) | 2.59466172 |
| 55 | Congenital hepatic fibrosis (HP:0002612) | 2.58454156 |
| 56 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.57857495 |
| 57 | Bile duct proliferation (HP:0001408) | 2.57585218 |
| 58 | Abnormal biliary tract physiology (HP:0012439) | 2.57585218 |
| 59 | Type II lissencephaly (HP:0007260) | 2.52638862 |
| 60 | Nephrogenic diabetes insipidus (HP:0009806) | 2.48543136 |
| 61 | Pendular nystagmus (HP:0012043) | 2.47147299 |
| 62 | Congenital primary aphakia (HP:0007707) | 2.44114139 |
| 63 | Male pseudohermaphroditism (HP:0000037) | 2.42187225 |
| 64 | Birth length less than 3rd percentile (HP:0003561) | 2.41367782 |
| 65 | Abnormality of macular pigmentation (HP:0008002) | 2.38469974 |
| 66 | Fair hair (HP:0002286) | 2.37789861 |
| 67 | Breast hypoplasia (HP:0003187) | 2.35671548 |
| 68 | Polydipsia (HP:0001959) | 2.35338949 |
| 69 | Abnormal drinking behavior (HP:0030082) | 2.35338949 |
| 70 | Abnormality of the renal medulla (HP:0100957) | 2.33398727 |
| 71 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.33268122 |
| 72 | Anencephaly (HP:0002323) | 2.32992306 |
| 73 | Emotional lability (HP:0000712) | 2.32436353 |
| 74 | Progressive external ophthalmoplegia (HP:0000590) | 2.32186146 |
| 75 | Genital tract atresia (HP:0001827) | 2.31702617 |
| 76 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.26973643 |
| 77 | Delusions (HP:0000746) | 2.26587847 |
| 78 | Sclerocornea (HP:0000647) | 2.25960892 |
| 79 | Decreased circulating renin level (HP:0003351) | 2.24456605 |
| 80 | Abnormality of the axillary hair (HP:0100134) | 2.18854180 |
| 81 | Abnormality of secondary sexual hair (HP:0009888) | 2.18854180 |
| 82 | Amniotic constriction ring (HP:0009775) | 2.18308058 |
| 83 | Abnormality of placental membranes (HP:0011409) | 2.18308058 |
| 84 | Decreased central vision (HP:0007663) | 2.14414133 |
| 85 | Methylmalonic aciduria (HP:0012120) | 2.14412102 |
| 86 | Postaxial foot polydactyly (HP:0001830) | 2.13868956 |
| 87 | Vaginal atresia (HP:0000148) | 2.13571364 |
| 88 | Oligodactyly (hands) (HP:0001180) | 2.11113993 |
| 89 | Chronic bronchitis (HP:0004469) | 2.10182532 |
| 90 | Hyperphosphaturia (HP:0003109) | 2.08464170 |
| 91 | Abnormality of vitamin B metabolism (HP:0004340) | 2.06835993 |
| 92 | Carpal bone hypoplasia (HP:0001498) | 2.06333621 |
| 93 | Azoospermia (HP:0000027) | 2.05895414 |
| 94 | X-linked dominant inheritance (HP:0001423) | 2.05443519 |
| 95 | Supernumerary spleens (HP:0009799) | 2.05382332 |
| 96 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.04801882 |
| 97 | Microvesicular hepatic steatosis (HP:0001414) | 2.04230943 |
| 98 | Attenuation of retinal blood vessels (HP:0007843) | 2.03383325 |
| 99 | Anterior segment dysgenesis (HP:0007700) | 2.03120145 |
| 100 | Hypokalemic alkalosis (HP:0001949) | 2.03068202 |
| 101 | Median cleft lip (HP:0000161) | 2.02872034 |
| 102 | Furrowed tongue (HP:0000221) | 2.01680904 |
| 103 | Prostate neoplasm (HP:0100787) | 2.01638347 |
| 104 | Volvulus (HP:0002580) | 2.00483483 |
| 105 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.99219293 |
| 106 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.99219293 |
| 107 | Lethargy (HP:0001254) | 1.99071499 |
| 108 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.98752590 |
| 109 | Glycosuria (HP:0003076) | 1.97736076 |
| 110 | Abnormality of urine glucose concentration (HP:0011016) | 1.97736076 |
| 111 | Optic nerve hypoplasia (HP:0000609) | 1.96799978 |
| 112 | Poor coordination (HP:0002370) | 1.95142954 |
| 113 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.94457334 |
| 114 | Rough bone trabeculation (HP:0100670) | 1.92457786 |
| 115 | Severe visual impairment (HP:0001141) | 1.91957173 |
| 116 | Congenital, generalized hypertrichosis (HP:0004540) | 1.91444608 |
| 117 | Focal motor seizures (HP:0011153) | 1.90832900 |
| 118 | Neoplasm of the adrenal cortex (HP:0100641) | 1.90613702 |
| 119 | Type I transferrin isoform profile (HP:0003642) | 1.89278379 |
| 120 | Abolished electroretinogram (ERG) (HP:0000550) | 1.89008176 |
| 121 | Limb dystonia (HP:0002451) | 1.86155030 |
| 122 | Gaze-evoked nystagmus (HP:0000640) | 1.85469595 |
| 123 | Blindness (HP:0000618) | 1.85372635 |
| 124 | Keratoconus (HP:0000563) | 1.84224460 |
| 125 | Increased corneal curvature (HP:0100692) | 1.84224460 |
| 126 | Secondary amenorrhea (HP:0000869) | 1.84139100 |
| 127 | Abnormal pupillary function (HP:0007686) | 1.83982838 |
| 128 | Aplastic anemia (HP:0001915) | 1.83489184 |
| 129 | Postaxial hand polydactyly (HP:0001162) | 1.83269398 |
| 130 | CNS hypomyelination (HP:0003429) | 1.83107395 |
| 131 | Abnormality of the renal cortex (HP:0011035) | 1.81900786 |
| 132 | Polyphagia (HP:0002591) | 1.81300312 |
| 133 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.80016184 |
| 134 | Oral leukoplakia (HP:0002745) | 1.79844638 |
| 135 | Tubular atrophy (HP:0000092) | 1.78986804 |
| 136 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.78747718 |
| 137 | Woolly hair (HP:0002224) | 1.78740611 |
| 138 | Bifid tongue (HP:0010297) | 1.76906530 |
| 139 | Hypoplasia of the pons (HP:0012110) | 1.76082101 |
| 140 | Polyuria (HP:0000103) | 1.76022078 |
| 141 | Severe muscular hypotonia (HP:0006829) | 1.74232077 |
| 142 | Progressive inability to walk (HP:0002505) | 1.73886026 |
| 143 | Lissencephaly (HP:0001339) | 1.73126288 |
| 144 | Amblyopia (HP:0000646) | 1.73003142 |
| 145 | Renal tubular dysfunction (HP:0000124) | 1.72781900 |
| 146 | Medial flaring of the eyebrow (HP:0010747) | 1.71229683 |
| 147 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.70937213 |
| 148 | Absent/shortened dynein arms (HP:0200106) | 1.70937213 |
| 149 | Abnormal urine phosphate concentration (HP:0012599) | 1.67232847 |
| 150 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.67211721 |
| 151 | Absent thumb (HP:0009777) | 1.65863946 |
| 152 | Stenosis of the external auditory canal (HP:0000402) | 1.65454178 |
| 153 | Hypothermia (HP:0002045) | 1.64154137 |
| 154 | Duplicated collecting system (HP:0000081) | 1.62328890 |
| 155 | Gliosis (HP:0002171) | 1.61754425 |
| 156 | Horseshoe kidney (HP:0000085) | 1.61214946 |
| 157 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.59501451 |
| 158 | Triphalangeal thumb (HP:0001199) | 1.58994051 |
| 159 | Multiple enchondromatosis (HP:0005701) | 1.58965158 |
| 160 | Abnormal ciliary motility (HP:0012262) | 1.58738663 |
| 161 | Cleft eyelid (HP:0000625) | 1.58539279 |
| 162 | Type 2 muscle fiber atrophy (HP:0003554) | 1.58036477 |
| 163 | Myokymia (HP:0002411) | 1.57521790 |
| 164 | Pancreatic fibrosis (HP:0100732) | 1.56083180 |
| 165 | External ophthalmoplegia (HP:0000544) | 1.55661606 |
| 166 | Patellar aplasia (HP:0006443) | 1.52639951 |
| 167 | Concave nail (HP:0001598) | 1.51999883 |
| 168 | Abnormal hemoglobin (HP:0011902) | 1.51593648 |
| 169 | Sparse eyelashes (HP:0000653) | 1.51222764 |
| 170 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.49565440 |
| 171 | Unsteady gait (HP:0002317) | 1.49396549 |
| 172 | Muscle fiber atrophy (HP:0100295) | 1.49092389 |
| 173 | Absent radius (HP:0003974) | 1.48445170 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NME2 | 4.24661718 |
| 2 | FRK | 4.11093622 |
| 3 | STK16 | 3.86064426 |
| 4 | BUB1 | 3.78974756 |
| 5 | NUAK1 | 3.65758518 |
| 6 | NME1 | 2.79795990 |
| 7 | WEE1 | 2.74970171 |
| 8 | PNCK | 2.65217874 |
| 9 | WNK3 | 2.61444650 |
| 10 | SRPK1 | 2.49312711 |
| 11 | VRK1 | 2.31538968 |
| 12 | GRK1 | 2.23696905 |
| 13 | EIF2AK1 | 2.15483111 |
| 14 | PLK4 | 2.09578988 |
| 15 | MUSK | 2.09507374 |
| 16 | TLK1 | 1.96664201 |
| 17 | VRK2 | 1.94865320 |
| 18 | TESK2 | 1.92788480 |
| 19 | IRAK3 | 1.92158640 |
| 20 | EIF2AK3 | 1.90055808 |
| 21 | MAP3K12 | 1.88815679 |
| 22 | MST4 | 1.86350570 |
| 23 | ARAF | 1.86199118 |
| 24 | LATS1 | 1.84285311 |
| 25 | STK3 | 1.77690238 |
| 26 | NTRK3 | 1.74665578 |
| 27 | LIMK1 | 1.72074278 |
| 28 | CASK | 1.65713632 |
| 29 | GRK5 | 1.62655480 |
| 30 | STK39 | 1.59394593 |
| 31 | MAP4K2 | 1.57286070 |
| 32 | PIM2 | 1.54675783 |
| 33 | PBK | 1.46794802 |
| 34 | MYLK | 1.45539508 |
| 35 | TSSK6 | 1.43135667 |
| 36 | DYRK2 | 1.39449162 |
| 37 | MAPKAPK5 | 1.30077302 |
| 38 | ADRBK2 | 1.26610602 |
| 39 | DAPK2 | 1.25041942 |
| 40 | TNIK | 1.24680323 |
| 41 | GRK7 | 1.24504298 |
| 42 | ZAK | 1.19529315 |
| 43 | INSRR | 1.17301121 |
| 44 | BRAF | 1.15893450 |
| 45 | TESK1 | 1.15760633 |
| 46 | DYRK3 | 1.15414091 |
| 47 | CDK19 | 1.10768359 |
| 48 | ABL2 | 1.08484087 |
| 49 | STK38L | 1.05222024 |
| 50 | MARK1 | 1.03893194 |
| 51 | BMPR1B | 1.03114279 |
| 52 | IRAK4 | 0.99935008 |
| 53 | OXSR1 | 0.99533754 |
| 54 | IRAK2 | 0.99328755 |
| 55 | AURKA | 0.97422203 |
| 56 | PRKCE | 0.95559921 |
| 57 | MKNK1 | 0.94244082 |
| 58 | PHKG2 | 0.93914774 |
| 59 | PHKG1 | 0.93914774 |
| 60 | CSNK1G3 | 0.93626730 |
| 61 | KDR | 0.92515618 |
| 62 | BCR | 0.91571202 |
| 63 | TAOK3 | 0.90998334 |
| 64 | PLK3 | 0.90314521 |
| 65 | PRKG2 | 0.90280552 |
| 66 | PRKCG | 0.87357089 |
| 67 | CDK3 | 0.86337678 |
| 68 | NEK2 | 0.86131893 |
| 69 | CDC7 | 0.84694395 |
| 70 | MAPK13 | 0.83498890 |
| 71 | PLK1 | 0.83355725 |
| 72 | IRAK1 | 0.83156484 |
| 73 | TEC | 0.82537144 |
| 74 | SIK2 | 0.81686403 |
| 75 | WNK4 | 0.79376682 |
| 76 | NTRK2 | 0.77644314 |
| 77 | RPS6KA5 | 0.76090275 |
| 78 | MAP3K4 | 0.75972714 |
| 79 | EIF2AK2 | 0.75403383 |
| 80 | CDK8 | 0.73120516 |
| 81 | CAMK2B | 0.72502474 |
| 82 | MKNK2 | 0.72042443 |
| 83 | EPHA2 | 0.71879440 |
| 84 | PINK1 | 0.71802607 |
| 85 | TRPM7 | 0.71686879 |
| 86 | OBSCN | 0.71673623 |
| 87 | DYRK1A | 0.71153612 |
| 88 | CSNK1G1 | 0.70705886 |
| 89 | PAK3 | 0.70042620 |
| 90 | CSNK2A1 | 0.68493359 |
| 91 | TXK | 0.68455905 |
| 92 | STK24 | 0.68003850 |
| 93 | TNK2 | 0.67464041 |
| 94 | BCKDK | 0.65822798 |
| 95 | CSNK2A2 | 0.64629342 |
| 96 | BMPR2 | 0.64145970 |
| 97 | PIK3CA | 0.61303780 |
| 98 | TIE1 | 0.61241307 |
| 99 | AURKB | 0.60759014 |
| 100 | SYK | 0.60064509 |
| 101 | DMPK | 0.59815036 |
| 102 | PAK1 | 0.58561761 |
| 103 | DAPK3 | 0.58214749 |
| 104 | PLK2 | 0.57891095 |
| 105 | BRSK2 | 0.57218926 |
| 106 | CCNB1 | 0.55341960 |
| 107 | CAMK2D | 0.54975932 |
| 108 | UHMK1 | 0.54781360 |
| 109 | WNK1 | 0.53555565 |
| 110 | RPS6KB2 | 0.52921425 |
| 111 | CDK7 | 0.52574007 |
| 112 | MAP2K7 | 0.52279225 |
| 113 | PRKCI | 0.52019361 |
| 114 | CHEK2 | 0.51607543 |
| 115 | CAMK2G | 0.49384337 |
| 116 | PRKCQ | 0.49247993 |
| 117 | TAOK1 | 0.49034920 |
| 118 | CAMK2A | 0.48512360 |
| 119 | PASK | 0.48025868 |
| 120 | ADRBK1 | 0.46186402 |
| 121 | LATS2 | 0.46138868 |
| 122 | PRKG1 | 0.45893359 |
| 123 | TTK | 0.44918648 |
| 124 | MAP3K11 | 0.44814884 |
| 125 | ERBB3 | 0.43508890 |
| 126 | AKT3 | 0.43366596 |
| 127 | PRKCZ | 0.43199421 |
| 128 | PIK3CG | 0.42715647 |
| 129 | FGFR2 | 0.42143143 |
| 130 | NEK6 | 0.42135219 |
| 131 | ACVR1B | 0.41548953 |
| 132 | CSNK1A1 | 0.41421531 |
| 133 | CDK9 | 0.41359414 |
| 134 | CAMK1 | 0.40750574 |
| 135 | MINK1 | 0.40605211 |
| 136 | CSNK1D | 0.40394011 |
| 137 | ILK | 0.38917996 |
| 138 | PTK2B | 0.38814231 |
| 139 | STK11 | 0.38196647 |
| 140 | CSNK1E | 0.37823162 |
| 141 | BLK | 0.37578246 |
| 142 | CDK5 | 0.36469046 |
| 143 | MAPK4 | 0.36379044 |
| 144 | MAP3K9 | 0.35563468 |
| 145 | PKN1 | 0.35526306 |
| 146 | ABL1 | 0.35097503 |
| 147 | CDK14 | 0.34972491 |
| 148 | PRKACA | 0.34960395 |
| 149 | MAPKAPK3 | 0.34778637 |
| 150 | CSNK1G2 | 0.34407553 |
| 151 | PDK3 | 0.34371555 |
| 152 | PDK4 | 0.34371555 |
| 153 | ROCK2 | 0.33006635 |
| 154 | CDK11A | 0.32114252 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 5.49177895 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 5.41438399 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 4.71382038 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 4.43591555 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 4.18475027 |
| 6 | Huntingtons disease_Homo sapiens_hsa05016 | 3.59967160 |
| 7 | Alzheimers disease_Homo sapiens_hsa05010 | 3.44602872 |
| 8 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.94314013 |
| 9 | Protein export_Homo sapiens_hsa03060 | 2.64003741 |
| 10 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.37591635 |
| 11 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.27730848 |
| 12 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.15780052 |
| 13 | Spliceosome_Homo sapiens_hsa03040 | 2.04950430 |
| 14 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.02182099 |
| 15 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.97714016 |
| 16 | DNA replication_Homo sapiens_hsa03030 | 1.78861515 |
| 17 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.71324510 |
| 18 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.70814292 |
| 19 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.69491795 |
| 20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.63691982 |
| 21 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.58693666 |
| 22 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.57868075 |
| 23 | Mismatch repair_Homo sapiens_hsa03430 | 1.56004884 |
| 24 | Olfactory transduction_Homo sapiens_hsa04740 | 1.53397434 |
| 25 | Homologous recombination_Homo sapiens_hsa03440 | 1.53154542 |
| 26 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.52786157 |
| 27 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.50096848 |
| 28 | Morphine addiction_Homo sapiens_hsa05032 | 1.47754758 |
| 29 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.39961383 |
| 30 | Purine metabolism_Homo sapiens_hsa00230 | 1.39833954 |
| 31 | RNA transport_Homo sapiens_hsa03013 | 1.35713918 |
| 32 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.32889011 |
| 33 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.32487196 |
| 34 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.29594143 |
| 35 | GABAergic synapse_Homo sapiens_hsa04727 | 1.17163879 |
| 36 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.16145027 |
| 37 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.12626657 |
| 38 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.12275123 |
| 39 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.10591794 |
| 40 | RNA degradation_Homo sapiens_hsa03018 | 1.07181521 |
| 41 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.06822057 |
| 42 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.04150501 |
| 43 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 1.01667410 |
| 44 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.96556954 |
| 45 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.94437124 |
| 46 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.92709409 |
| 47 | Base excision repair_Homo sapiens_hsa03410 | 0.91507935 |
| 48 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.87255238 |
| 49 | Metabolic pathways_Homo sapiens_hsa01100 | 0.87220319 |
| 50 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.84019689 |
| 51 | Circadian entrainment_Homo sapiens_hsa04713 | 0.79877516 |
| 52 | Sulfur relay system_Homo sapiens_hsa04122 | 0.79677544 |
| 53 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.79224431 |
| 54 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.76876971 |
| 55 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.74220101 |
| 56 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.71894955 |
| 57 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.71026320 |
| 58 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.69778063 |
| 59 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.67754247 |
| 60 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.66894641 |
| 61 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.66143977 |
| 62 | Insulin secretion_Homo sapiens_hsa04911 | 0.66130749 |
| 63 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.65334794 |
| 64 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.64473181 |
| 65 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.64134176 |
| 66 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.63342505 |
| 67 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.58471773 |
| 68 | Cell cycle_Homo sapiens_hsa04110 | 0.57259945 |
| 69 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.56987578 |
| 70 | Phototransduction_Homo sapiens_hsa04744 | 0.56364563 |
| 71 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.55359954 |
| 72 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.55127320 |
| 73 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.53038864 |
| 74 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.52512457 |
| 75 | ABC transporters_Homo sapiens_hsa02010 | 0.51789790 |
| 76 | Nicotine addiction_Homo sapiens_hsa05033 | 0.51405949 |
| 77 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.51148115 |
| 78 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.50771695 |
| 79 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.49642891 |
| 80 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.45896009 |
| 81 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.45029076 |
| 82 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.44988895 |
| 83 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.42148490 |
| 84 | Salivary secretion_Homo sapiens_hsa04970 | 0.42001639 |
| 85 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.41712972 |
| 86 | Long-term depression_Homo sapiens_hsa04730 | 0.39304366 |
| 87 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.38960506 |
| 88 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.38489262 |
| 89 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.38389896 |
| 90 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.37863739 |
| 91 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.36918031 |
| 92 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.36195635 |
| 93 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.35178200 |
| 94 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.34993887 |
| 95 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.34702659 |
| 96 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.33951946 |
| 97 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.33625691 |
| 98 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.33555429 |
| 99 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.33045521 |
| 100 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.32042993 |
| 101 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.31352945 |
| 102 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.30793249 |
| 103 | Taste transduction_Homo sapiens_hsa04742 | 0.29888557 |
| 104 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.29828754 |
| 105 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.28821094 |
| 106 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.27522895 |
| 107 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.27334650 |
| 108 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.26711292 |
| 109 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.26074519 |
| 110 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.25783316 |
| 111 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.24062309 |
| 112 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.24030476 |
| 113 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.23916262 |
| 114 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.23570645 |
| 115 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.23532512 |
| 116 | Asthma_Homo sapiens_hsa05310 | 0.23029139 |
| 117 | Allograft rejection_Homo sapiens_hsa05330 | 0.22982469 |
| 118 | Phagosome_Homo sapiens_hsa04145 | 0.21892176 |
| 119 | Histidine metabolism_Homo sapiens_hsa00340 | 0.19678991 |
| 120 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.19636841 |
| 121 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.19372358 |
| 122 | Carbon metabolism_Homo sapiens_hsa01200 | 0.18194955 |
| 123 | Alcoholism_Homo sapiens_hsa05034 | 0.15681037 |
| 124 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.12406327 |
| 125 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.12321479 |
| 126 | Peroxisome_Homo sapiens_hsa04146 | 0.12108075 |
| 127 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.11728773 |
| 128 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.11177753 |
| 129 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.11109235 |
| 130 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.05453647 |
| 131 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.05176601 |
| 132 | Retinol metabolism_Homo sapiens_hsa00830 | 0.04450758 |
| 133 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.03847509 |
| 134 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.03760053 |
| 135 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.03346530 |

