USP50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.91889709
2ATP synthesis coupled proton transport (GO:0015986)7.44189008
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.44189008
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.96958154
5ribosomal small subunit biogenesis (GO:0042274)6.75542092
6regulation of meiosis I (GO:0060631)6.10603722
7respiratory electron transport chain (GO:0022904)6.07739826
8behavioral response to nicotine (GO:0035095)6.06009318
9viral transcription (GO:0019083)5.95868153
10electron transport chain (GO:0022900)5.93254173
11translational termination (GO:0006415)5.74331033
12chaperone-mediated protein transport (GO:0072321)5.73119873
13protein neddylation (GO:0045116)5.41928049
14establishment of protein localization to mitochondrial membrane (GO:0090151)5.39209311
15proteasome assembly (GO:0043248)5.26778200
16cotranslational protein targeting to membrane (GO:0006613)5.20020565
17transcription elongation from RNA polymerase III promoter (GO:0006385)5.18484512
18termination of RNA polymerase III transcription (GO:0006386)5.18484512
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.17279218
20protein targeting to ER (GO:0045047)5.11936951
21maturation of SSU-rRNA (GO:0030490)5.08791312
22ribosomal small subunit assembly (GO:0000028)5.00248896
23protein localization to endoplasmic reticulum (GO:0070972)4.90773165
24establishment of protein localization to endoplasmic reticulum (GO:0072599)4.87761600
25piRNA metabolic process (GO:0034587)4.85804500
26translational elongation (GO:0006414)4.85708547
27GTP biosynthetic process (GO:0006183)4.70917818
28cellular protein complex disassembly (GO:0043624)4.65591217
29protein complex biogenesis (GO:0070271)4.57793970
30regulation of female gonad development (GO:2000194)4.55928898
31viral life cycle (GO:0019058)4.55465959
32mitochondrial respiratory chain complex I assembly (GO:0032981)4.51246272
33NADH dehydrogenase complex assembly (GO:0010257)4.51246272
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.51246272
35DNA deamination (GO:0045006)4.48042187
367-methylguanosine mRNA capping (GO:0006370)4.46779686
37ribosomal large subunit biogenesis (GO:0042273)4.45392540
38platelet dense granule organization (GO:0060155)4.44648373
39translational initiation (GO:0006413)4.42118268
40RNA capping (GO:0036260)4.39566450
417-methylguanosine RNA capping (GO:0009452)4.39566450
42regulation of mitochondrial translation (GO:0070129)4.36559709
43translation (GO:0006412)4.32678626
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.27467423
45mitochondrial respiratory chain complex assembly (GO:0033108)4.21085150
46UTP biosynthetic process (GO:0006228)4.11787178
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.00696849
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.00175938
49protein targeting to mitochondrion (GO:0006626)3.99206999
50regulation of cellular amino acid metabolic process (GO:0006521)3.98118387
51establishment of protein localization to mitochondrion (GO:0072655)3.97793927
52ribonucleoprotein complex biogenesis (GO:0022613)3.94436139
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.94408893
54guanosine-containing compound biosynthetic process (GO:1901070)3.90259383
55cellular component biogenesis (GO:0044085)3.89298755
56DNA methylation involved in gamete generation (GO:0043046)3.89216058
57protein complex disassembly (GO:0043241)3.88272509
58DNA double-strand break processing (GO:0000729)3.87078939
59purine nucleoside triphosphate biosynthetic process (GO:0009145)3.84891452
60establishment of integrated proviral latency (GO:0075713)3.81057634
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.74729879
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.72735637
63negative regulation of ligase activity (GO:0051352)3.72735637
64macromolecular complex disassembly (GO:0032984)3.72664195
65ATP biosynthetic process (GO:0006754)3.72549201
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.69747260
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.69747260
68hydrogen ion transmembrane transport (GO:1902600)3.69089659
69transcription elongation from RNA polymerase I promoter (GO:0006362)3.68047573
70positive regulation of histone H3-K4 methylation (GO:0051571)3.67305885
71protein localization to mitochondrion (GO:0070585)3.66026395
72response to pheromone (GO:0019236)3.66000334
73neurofilament cytoskeleton organization (GO:0060052)3.61315111
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.60884191
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.59535596
76transcription from RNA polymerase I promoter (GO:0006360)3.56628053
77multicellular organism reproduction (GO:0032504)3.54910308
78anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.53822661
79signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.52719617
80signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.52719617
81signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.52719617
82rRNA modification (GO:0000154)3.52547334
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.51437240
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.51437240
85ribonucleoside triphosphate biosynthetic process (GO:0009201)3.50237549
86UTP metabolic process (GO:0046051)3.48190496
87termination of RNA polymerase I transcription (GO:0006363)3.48137706
88synaptic transmission, cholinergic (GO:0007271)3.47785646
89L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.46887313
90rRNA processing (GO:0006364)3.46027543
91spliceosomal snRNP assembly (GO:0000387)3.45839339
92signal transduction involved in DNA integrity checkpoint (GO:0072401)3.44472614
93signal transduction involved in DNA damage checkpoint (GO:0072422)3.44472614
94protein-cofactor linkage (GO:0018065)3.43912527
95protein localization to cilium (GO:0061512)3.43586659
96respiratory chain complex IV assembly (GO:0008535)3.41750378
97signal transduction involved in cell cycle checkpoint (GO:0072395)3.40719426
98protein targeting to membrane (GO:0006612)3.40051980
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.38018967
100peptidyl-histidine modification (GO:0018202)3.35834865
101nucleobase catabolic process (GO:0046113)3.35195065
102inner mitochondrial membrane organization (GO:0007007)3.35124735
103establishment of viral latency (GO:0019043)3.33891172
104norepinephrine metabolic process (GO:0042415)3.33382159
105cullin deneddylation (GO:0010388)3.32463403
106CTP metabolic process (GO:0046036)3.32298189
107CTP biosynthetic process (GO:0006241)3.32298189
108rRNA metabolic process (GO:0016072)3.30931036
109dopamine transport (GO:0015872)3.29483287
110nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29074628
111detection of light stimulus involved in visual perception (GO:0050908)3.26523516
112detection of light stimulus involved in sensory perception (GO:0050962)3.26523516
113exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24455667
114proton transport (GO:0015992)3.23115505
115positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.21427466
116positive regulation of meiosis (GO:0045836)3.20544403
117spliceosomal complex assembly (GO:0000245)3.19809188
118oxidative phosphorylation (GO:0006119)3.16741127
119hydrogen transport (GO:0006818)3.15081965
120protein deneddylation (GO:0000338)3.13101435
121positive regulation of ligase activity (GO:0051351)3.11726184
122nucleoside triphosphate biosynthetic process (GO:0009142)3.11291654
123nonmotile primary cilium assembly (GO:0035058)3.09147331
124retinal cone cell development (GO:0046549)3.08593911
125protein prenylation (GO:0018342)3.07182127
126prenylation (GO:0097354)3.07182127
127cellular ketone body metabolic process (GO:0046950)3.06852562
128ketone body metabolic process (GO:1902224)3.06248048
129meiotic cell cycle (GO:0051321)3.05248731
130ubiquinone biosynthetic process (GO:0006744)3.01696632
131photoreceptor cell maintenance (GO:0045494)2.97439407
132positive regulation of meiotic cell cycle (GO:0051446)2.97150424
133alanine transport (GO:0032328)2.93703396
134negative regulation of telomere maintenance (GO:0032205)2.92700206
135G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.91502115
136axoneme assembly (GO:0035082)2.87325520
137epithelial cilium movement (GO:0003351)2.87172260
138regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84146004
139regulation of mitotic spindle checkpoint (GO:1903504)2.84146004
140pyrimidine nucleobase catabolic process (GO:0006208)2.83934034
141serotonin metabolic process (GO:0042428)2.82425327
142female gamete generation (GO:0007292)2.81620199
143phosphorylated carbohydrate dephosphorylation (GO:0046838)2.81534179
144inositol phosphate dephosphorylation (GO:0046855)2.81534179
145detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.78446017
146L-fucose catabolic process (GO:0042355)2.77311218
147fucose catabolic process (GO:0019317)2.77311218
148L-fucose metabolic process (GO:0042354)2.77311218
149inositol phosphate catabolic process (GO:0071545)2.75748559
150primary amino compound metabolic process (GO:1901160)2.74882915
151intraciliary transport (GO:0042073)2.74673205
152ubiquinone metabolic process (GO:0006743)2.72293527
153mismatch repair (GO:0006298)2.71568403
154cornea development in camera-type eye (GO:0061303)2.70629947
155maturation of 5.8S rRNA (GO:0000460)2.70339185
156phosphorelay signal transduction system (GO:0000160)2.70301292
157recombinational repair (GO:0000725)2.64830781
158regulation of DNA methylation (GO:0044030)2.64482612
159centriole replication (GO:0007099)2.64443953
160double-strand break repair via homologous recombination (GO:0000724)2.64393249
161quinone biosynthetic process (GO:1901663)2.63149447
162photoreceptor cell development (GO:0042461)2.61345043
163regulation of action potential (GO:0098900)2.60836648
164transmission of nerve impulse (GO:0019226)2.59231835
165cilium or flagellum-dependent cell motility (GO:0001539)2.55181110
166relaxation of smooth muscle (GO:0044557)2.53044023
167regulation of acrosome reaction (GO:0060046)2.52913707
168proline transport (GO:0015824)2.51357410
169catechol-containing compound biosynthetic process (GO:0009713)2.50399948
170catecholamine biosynthetic process (GO:0042423)2.50399948
171C4-dicarboxylate transport (GO:0015740)2.49091197
172synapsis (GO:0007129)2.48483377
173DNA replication checkpoint (GO:0000076)2.46553194
174DNA damage response, detection of DNA damage (GO:0042769)2.46492694
175sperm motility (GO:0030317)2.44811783
176regulation of oxidative phosphorylation (GO:0002082)2.43971572
177cAMP catabolic process (GO:0006198)2.43061866
178cilium movement (GO:0003341)2.42799526
179serotonin receptor signaling pathway (GO:0007210)2.42762691
180regulation of cilium movement (GO:0003352)2.42331478
181cytochrome complex assembly (GO:0017004)2.41823380
182positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.41200107

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.27990490
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.99442891
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.69789685
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.44616671
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.28976950
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.24229099
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.13113354
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.88385357
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.82854530
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.44884437
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.35710882
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.30370966
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.28790186
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.17578431
15ZNF274_21170338_ChIP-Seq_K562_Hela3.10646904
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92201763
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85322505
18GBX2_23144817_ChIP-Seq_PC3_Human2.74481615
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52813060
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51360773
21VDR_23849224_ChIP-Seq_CD4+_Human2.49654947
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45635661
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.36284424
24XRN2_22483619_ChIP-Seq_HELA_Human2.26200521
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.25933187
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.21361121
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.20049798
28* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19520297
29DCP1A_22483619_ChIP-Seq_HELA_Human2.18187858
30POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17346918
31SALL1_21062744_ChIP-ChIP_HESCs_Human2.10901985
32CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06120332
33ELK1_19687146_ChIP-ChIP_HELA_Human2.05586288
34E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02447175
35TTF2_22483619_ChIP-Seq_HELA_Human2.01733218
36IGF1R_20145208_ChIP-Seq_DFB_Human1.97782778
37EWS_26573619_Chip-Seq_HEK293_Human1.97752394
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93566802
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.92704211
40CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.91794968
41FOXP3_21729870_ChIP-Seq_TREG_Human1.90649727
42P300_19829295_ChIP-Seq_ESCs_Human1.87330589
43ELK1_22589737_ChIP-Seq_MCF10A_Human1.82953805
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76465788
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76270903
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74768538
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.73811243
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73811243
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73748810
50* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72904091
51AR_25329375_ChIP-Seq_VCAP_Human1.72642239
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.72417587
53CBP_20019798_ChIP-Seq_JUKART_Human1.72417587
54BCAT_22108803_ChIP-Seq_LS180_Human1.71360834
55GABP_19822575_ChIP-Seq_HepG2_Human1.70456320
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.68046650
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67207209
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62233578
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62098808
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58930282
61SMAD4_21799915_ChIP-Seq_A2780_Human1.58029577
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57660066
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.56412575
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53118985
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49963872
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49072834
67* TCF4_23295773_ChIP-Seq_U87_Human1.47899052
68* ER_23166858_ChIP-Seq_MCF-7_Human1.47520209
69SOX2_19829295_ChIP-Seq_ESCs_Human1.46048579
70NANOG_19829295_ChIP-Seq_ESCs_Human1.46048579
71RUNX2_22187159_ChIP-Seq_PCA_Human1.41029931
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40647129
73IRF1_19129219_ChIP-ChIP_H3396_Human1.40282918
74REST_21632747_ChIP-Seq_MESCs_Mouse1.40220183
75FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40170154
76RNF2_27304074_Chip-Seq_NSC_Mouse1.39058428
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37626146
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37549440
79* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37369248
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.37357000
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35589330
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35297316
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.35297316
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.34677139
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34577816
86VDR_22108803_ChIP-Seq_LS180_Human1.33426287
87TCF4_22108803_ChIP-Seq_LS180_Human1.33315866
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32742739
89TP53_22573176_ChIP-Seq_HFKS_Human1.32491931
90MYC_18940864_ChIP-ChIP_HL60_Human1.30075603
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29802266
92STAT3_23295773_ChIP-Seq_U87_Human1.29734591
93HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27838374
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27418870
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27250386
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26847380
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26375385
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25151676
99RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24719852
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.23359637
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21439928
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.20970864
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20580137
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16402349
105CBX2_27304074_Chip-Seq_ESCs_Mouse1.15601710
106SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14330827
107CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13997649
108NCOR_22424771_ChIP-Seq_293T_Human1.13629877
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.13173491
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12779130
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12720859
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.11527083
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.10980405
114JUN_21703547_ChIP-Seq_K562_Human1.09418073
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09416241
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08620772
117* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07521903
118GATA3_21878914_ChIP-Seq_MCF-7_Human1.07517895
119FOXH1_21741376_ChIP-Seq_EPCs_Human1.07508377
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07249584
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06731966
122SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06702842
123MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06005866
124CRX_20693478_ChIP-Seq_RETINA_Mouse1.05409665
125SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05308059
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04940914
127* STAT3_18555785_Chip-Seq_ESCs_Mouse1.04834515
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04420290
129FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01859566
130BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01682125
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01280781
132TP63_19390658_ChIP-ChIP_HaCaT_Human0.99562418
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99057956
134* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98903290
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98875285
136EZH2_27304074_Chip-Seq_ESCs_Mouse0.98385057
137EZH2_22144423_ChIP-Seq_EOC_Human0.97549315
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.97364963
139CDX2_22108803_ChIP-Seq_LS180_Human0.97288962
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97224581
141TAF15_26573619_Chip-Seq_HEK293_Human0.96885756
142BP1_19119308_ChIP-ChIP_Hs578T_Human0.96279728
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95393907
144TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94324293
145CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91966474
146SOX17_20123909_ChIP-Seq_XEN_Mouse0.91666507
147* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91180919
148PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91062193
149SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90049151
150KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89564863
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.88368531
152ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87566399
153POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87510111
154FLI1_27457419_Chip-Seq_LIVER_Mouse0.85530849
155SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85448865
156PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84994649
157CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84041020
158NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82633605
159HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80069786
160NOTCH1_21737748_ChIP-Seq_TLL_Human0.78958182
161SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77533821
162STAT1_20625510_ChIP-Seq_HELA_Human0.77260545
163ZFX_18555785_ChIP-Seq_MESCs_Mouse0.76003895
164PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.75153123
165FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.74308310
166CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.72724185
167HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.72568288
168OCT4_18692474_ChIP-Seq_MEFs_Mouse0.72271461
169SOX2_16153702_ChIP-ChIP_HESCs_Human0.70974236
170FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.70404269
171FUS_26573619_Chip-Seq_HEK293_Human0.68918798
172EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.68560879
173CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.66497094
174E2F7_22180533_ChIP-Seq_HELA_Human0.64757754
175NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.64238911
176CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.64215178
177FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64012961

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.87984768
2MP0001529_abnormal_vocalization4.01474466
3MP0003880_abnormal_central_pattern3.73853767
4MP0002138_abnormal_hepatobiliary_system3.15045540
5MP0001905_abnormal_dopamine_level3.10164944
6MP0006276_abnormal_autonomic_nervous2.88068945
7MP0003693_abnormal_embryo_hatching2.87771751
8MP0009697_abnormal_copulation2.78182202
9MP0003136_yellow_coat_color2.63042615
10MP0000569_abnormal_digit_pigmentation2.58482644
11MP0003718_maternal_effect2.57136826
12MP0003787_abnormal_imprinting2.50999398
13MP0003195_calcinosis2.37055127
14MP0003121_genomic_imprinting2.24356132
15MP0006036_abnormal_mitochondrial_physio2.23744484
16MP0004147_increased_porphyrin_level2.23146579
17MP0002653_abnormal_ependyma_morphology2.13897561
18MP0006292_abnormal_olfactory_placode2.12602953
19MP0004957_abnormal_blastocyst_morpholog2.08210703
20MP0008932_abnormal_embryonic_tissue2.06007535
21MP0005551_abnormal_eye_electrophysiolog2.04379280
22MP0002837_dystrophic_cardiac_calcinosis2.03849285
23MP0005646_abnormal_pituitary_gland2.03405886
24MP0006035_abnormal_mitochondrial_morpho1.98114513
25MP0005410_abnormal_fertilization1.97140920
26MP0001986_abnormal_taste_sensitivity1.92355271
27MP0002638_abnormal_pupillary_reflex1.90740093
28MP0003786_premature_aging1.82932557
29MP0001188_hyperpigmentation1.75346070
30MP0008058_abnormal_DNA_repair1.73876880
31MP0008057_abnormal_DNA_replication1.72432403
32MP0005645_abnormal_hypothalamus_physiol1.72322571
33MP0004142_abnormal_muscle_tone1.70865496
34MP0002163_abnormal_gland_morphology1.65216554
35MP0005409_darkened_coat_color1.61674675
36MP0002736_abnormal_nociception_after1.58803888
37MP0005423_abnormal_somatic_nervous1.55763525
38MP0004381_abnormal_hair_follicle1.55188840
39MP0002102_abnormal_ear_morphology1.55116713
40MP0003186_abnormal_redox_activity1.54103552
41MP0005499_abnormal_olfactory_system1.52588540
42MP0005394_taste/olfaction_phenotype1.52588540
43MP0003283_abnormal_digestive_organ1.52275338
44MP0001968_abnormal_touch/_nociception1.49827319
45MP0001727_abnormal_embryo_implantation1.47974882
46MP0003646_muscle_fatigue1.47565261
47MP0003123_paternal_imprinting1.47497970
48MP0002938_white_spotting1.45892569
49MP0003315_abnormal_perineum_morphology1.45687080
50MP0000372_irregular_coat_pigmentation1.43884779
51MP0002735_abnormal_chemical_nociception1.41208490
52MP0003077_abnormal_cell_cycle1.39739902
53MP0000566_synostosis1.37930954
54MP0005379_endocrine/exocrine_gland_phen1.36632559
55MP0005253_abnormal_eye_physiology1.35969781
56MP0004145_abnormal_muscle_electrophysio1.35758673
57MP0001440_abnormal_grooming_behavior1.34259016
58MP0005171_absent_coat_pigmentation1.33565081
59MP0001324_abnormal_eye_pigmentation1.31701792
60MP0000631_abnormal_neuroendocrine_gland1.29621966
61MP0003941_abnormal_skin_development1.25646829
62MP0002132_abnormal_respiratory_system1.24653790
63MP0002751_abnormal_autonomic_nervous1.24540308
64MP0000750_abnormal_muscle_regeneration1.23321795
65MP0002734_abnormal_mechanical_nocicepti1.22966694
66MP0010094_abnormal_chromosome_stability1.22433930
67MP0003111_abnormal_nucleus_morphology1.21675424
68MP0002160_abnormal_reproductive_system1.20265173
69MP0005075_abnormal_melanosome_morpholog1.19487984
70MP0003938_abnormal_ear_development1.17941593
71MP0002277_abnormal_respiratory_mucosa1.16731733
72MP0002272_abnormal_nervous_system1.15907840
73MP0001970_abnormal_pain_threshold1.15739270
74MP0008872_abnormal_physiological_respon1.14057514
75MP0004885_abnormal_endolymph1.13275209
76MP0003122_maternal_imprinting1.13100490
77MP0005408_hypopigmentation1.10237996
78MP0004742_abnormal_vestibular_system1.08937873
79MP0003635_abnormal_synaptic_transmissio1.06379726
80MP0002557_abnormal_social/conspecific_i1.05776541
81MP0008995_early_reproductive_senescence1.03592303
82MP0000427_abnormal_hair_cycle1.03205714
83MP0002095_abnormal_skin_pigmentation1.02163740
84MP0004043_abnormal_pH_regulation1.01813660
85MP0003806_abnormal_nucleotide_metabolis1.01550242
86MP0006072_abnormal_retinal_apoptosis1.00277642
87MP0005195_abnormal_posterior_eye1.00033357
88MP0008789_abnormal_olfactory_epithelium0.99830912
89MP0005389_reproductive_system_phenotype0.98763717
90MP0005167_abnormal_blood-brain_barrier0.97255494
91MP0002210_abnormal_sex_determination0.95829742
92MP0003698_abnormal_male_reproductive0.95629794
93MP0010386_abnormal_urinary_bladder0.94990742
94MP0001929_abnormal_gametogenesis0.94917254
95MP0000749_muscle_degeneration0.94739666
96MP0005174_abnormal_tail_pigmentation0.94591408
97MP0008260_abnormal_autophagy0.94245885
98MP0002876_abnormal_thyroid_physiology0.93892363
99MP0002063_abnormal_learning/memory/cond0.93852573
100MP0002733_abnormal_thermal_nociception0.93265296
101MP0004133_heterotaxia0.93262493
102MP0001485_abnormal_pinna_reflex0.91970763
103MP0000015_abnormal_ear_pigmentation0.91875634
104MP0002184_abnormal_innervation0.90525693
105MP0009745_abnormal_behavioral_response0.90446326
106MP0008875_abnormal_xenobiotic_pharmacok0.90216966
107MP0003137_abnormal_impulse_conducting0.89759302
108MP0001661_extended_life_span0.89478852
109MP0003011_delayed_dark_adaptation0.89306637
110MP0002752_abnormal_somatic_nervous0.88549270
111MP0005085_abnormal_gallbladder_physiolo0.88044881
112MP0006054_spinal_hemorrhage0.87335926
113MP0005451_abnormal_body_composition0.86814912
114MP0001984_abnormal_olfaction0.85886626
115MP0005395_other_phenotype0.85516292
116MP0001293_anophthalmia0.84841366
117MP0000358_abnormal_cell_content/0.84159271
118MP0002064_seizures0.83753174
119MP0000778_abnormal_nervous_system0.83385875
120MP0002229_neurodegeneration0.82938610
121MP0005503_abnormal_tendon_morphology0.82587773
122MP0001542_abnormal_bone_strength0.82513407
123MP0003890_abnormal_embryonic-extraembry0.81718667
124MP0004924_abnormal_behavior0.81341888
125MP0005386_behavior/neurological_phenoty0.81341888
126MP0005636_abnormal_mineral_homeostasis0.81295318
127MP0004215_abnormal_myocardial_fiber0.80221427
128MP0002572_abnormal_emotion/affect_behav0.79740473
129MP0000026_abnormal_inner_ear0.78696453
130MP0005084_abnormal_gallbladder_morpholo0.78528045
131MP0001145_abnormal_male_reproductive0.77617659
132MP0002067_abnormal_sensory_capabilities0.77023671
133MP0008877_abnormal_DNA_methylation0.76667580
134MP0009046_muscle_twitch0.75796601
135MP0000371_diluted_coat_color0.75186927
136MP0001501_abnormal_sleep_pattern0.73675154
137MP0005332_abnormal_amino_acid0.72604446
138MP0001764_abnormal_homeostasis0.72200200
139MP0001486_abnormal_startle_reflex0.71415583
140MP0003950_abnormal_plasma_membrane0.70690048
141MP0000653_abnormal_sex_gland0.69666197
142MP0001963_abnormal_hearing_physiology0.69497016
143MP0000751_myopathy0.68481146
144MP0009333_abnormal_splenocyte_physiolog0.67541584

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.78094788
2Mitochondrial inheritance (HP:0001427)6.05342451
3Abnormal mitochondria in muscle tissue (HP:0008316)5.98026614
4Progressive macrocephaly (HP:0004481)5.55540193
5Acute encephalopathy (HP:0006846)5.39380326
6Hepatocellular necrosis (HP:0001404)5.17955007
7Increased CSF lactate (HP:0002490)5.12502759
8Increased hepatocellular lipid droplets (HP:0006565)5.08101961
9Abnormality of cells of the erythroid lineage (HP:0012130)5.01170516
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.61833773
11Lipid accumulation in hepatocytes (HP:0006561)4.45790006
12Abnormal number of erythroid precursors (HP:0012131)4.43329948
13Hepatic necrosis (HP:0002605)4.38895576
14Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.34857088
15Renal Fanconi syndrome (HP:0001994)4.32169799
163-Methylglutaconic aciduria (HP:0003535)4.20233118
17Pancreatic cysts (HP:0001737)4.10932903
18Reticulocytopenia (HP:0001896)3.98281671
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.88693629
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.88693629
21True hermaphroditism (HP:0010459)3.70731141
22Cerebral edema (HP:0002181)3.69628078
23Increased intramyocellular lipid droplets (HP:0012240)3.64147290
24Exercise intolerance (HP:0003546)3.62627387
25Exertional dyspnea (HP:0002875)3.62268172
26Congenital stationary night blindness (HP:0007642)3.61118506
27Optic disc pallor (HP:0000543)3.55749487
28Macrocytic anemia (HP:0001972)3.51505917
29Respiratory failure (HP:0002878)3.51205970
30Increased serum lactate (HP:0002151)3.37802761
31Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.37660937
32Abnormality of midbrain morphology (HP:0002418)3.35184967
33Molar tooth sign on MRI (HP:0002419)3.35184967
34Lactic acidosis (HP:0003128)3.34534495
35Leukodystrophy (HP:0002415)3.26659473
36Respiratory difficulties (HP:0002880)3.09857925
37Abnormality of glycolysis (HP:0004366)3.06318016
38Increased serum pyruvate (HP:0003542)3.06318016
39Increased muscle lipid content (HP:0009058)3.02087542
40Ulnar claw (HP:0001178)2.97376325
41Pallor (HP:0000980)2.89776971
42Cerebral hypomyelination (HP:0006808)2.84068031
43Methylmalonic acidemia (HP:0002912)2.83853884
44Nephronophthisis (HP:0000090)2.83539952
45Abnormality of renal resorption (HP:0011038)2.79369579
46Aplasia/Hypoplasia of the fovea (HP:0008060)2.70395995
47Hypoplasia of the fovea (HP:0007750)2.70395995
48Hypoglycemic seizures (HP:0002173)2.67989663
49Parakeratosis (HP:0001036)2.64757908
50Cystic liver disease (HP:0006706)2.64497421
51Abnormality of the fovea (HP:0000493)2.64124143
52Aplasia/Hypoplasia of the tongue (HP:0010295)2.59950345
53CNS demyelination (HP:0007305)2.59798497
54Gait imbalance (HP:0002141)2.59466172
55Congenital hepatic fibrosis (HP:0002612)2.58454156
56Abnormal rod and cone electroretinograms (HP:0008323)2.57857495
57Bile duct proliferation (HP:0001408)2.57585218
58Abnormal biliary tract physiology (HP:0012439)2.57585218
59Type II lissencephaly (HP:0007260)2.52638862
60Nephrogenic diabetes insipidus (HP:0009806)2.48543136
61Pendular nystagmus (HP:0012043)2.47147299
62Congenital primary aphakia (HP:0007707)2.44114139
63Male pseudohermaphroditism (HP:0000037)2.42187225
64Birth length less than 3rd percentile (HP:0003561)2.41367782
65Abnormality of macular pigmentation (HP:0008002)2.38469974
66Fair hair (HP:0002286)2.37789861
67Breast hypoplasia (HP:0003187)2.35671548
68Polydipsia (HP:0001959)2.35338949
69Abnormal drinking behavior (HP:0030082)2.35338949
70Abnormality of the renal medulla (HP:0100957)2.33398727
71Aplasia/Hypoplasia of the sacrum (HP:0008517)2.33268122
72Anencephaly (HP:0002323)2.32992306
73Emotional lability (HP:0000712)2.32436353
74Progressive external ophthalmoplegia (HP:0000590)2.32186146
75Genital tract atresia (HP:0001827)2.31702617
76Congenital ichthyosiform erythroderma (HP:0007431)2.26973643
77Delusions (HP:0000746)2.26587847
78Sclerocornea (HP:0000647)2.25960892
79Decreased circulating renin level (HP:0003351)2.24456605
80Abnormality of the axillary hair (HP:0100134)2.18854180
81Abnormality of secondary sexual hair (HP:0009888)2.18854180
82Amniotic constriction ring (HP:0009775)2.18308058
83Abnormality of placental membranes (HP:0011409)2.18308058
84Decreased central vision (HP:0007663)2.14414133
85Methylmalonic aciduria (HP:0012120)2.14412102
86Postaxial foot polydactyly (HP:0001830)2.13868956
87Vaginal atresia (HP:0000148)2.13571364
88Oligodactyly (hands) (HP:0001180)2.11113993
89Chronic bronchitis (HP:0004469)2.10182532
90Hyperphosphaturia (HP:0003109)2.08464170
91Abnormality of vitamin B metabolism (HP:0004340)2.06835993
92Carpal bone hypoplasia (HP:0001498)2.06333621
93Azoospermia (HP:0000027)2.05895414
94X-linked dominant inheritance (HP:0001423)2.05443519
95Supernumerary spleens (HP:0009799)2.05382332
96Abnormality of the vitamin B12 metabolism (HP:0004341)2.04801882
97Microvesicular hepatic steatosis (HP:0001414)2.04230943
98Attenuation of retinal blood vessels (HP:0007843)2.03383325
99Anterior segment dysgenesis (HP:0007700)2.03120145
100Hypokalemic alkalosis (HP:0001949)2.03068202
101Median cleft lip (HP:0000161)2.02872034
102Furrowed tongue (HP:0000221)2.01680904
103Prostate neoplasm (HP:0100787)2.01638347
104Volvulus (HP:0002580)2.00483483
105Abnormal respiratory epithelium morphology (HP:0012253)1.99219293
106Abnormal respiratory motile cilium morphology (HP:0005938)1.99219293
107Lethargy (HP:0001254)1.99071499
108Aplasia/hypoplasia of the uterus (HP:0008684)1.98752590
109Glycosuria (HP:0003076)1.97736076
110Abnormality of urine glucose concentration (HP:0011016)1.97736076
111Optic nerve hypoplasia (HP:0000609)1.96799978
112Poor coordination (HP:0002370)1.95142954
113Hyperinsulinemic hypoglycemia (HP:0000825)1.94457334
114Rough bone trabeculation (HP:0100670)1.92457786
115Severe visual impairment (HP:0001141)1.91957173
116Congenital, generalized hypertrichosis (HP:0004540)1.91444608
117Focal motor seizures (HP:0011153)1.90832900
118Neoplasm of the adrenal cortex (HP:0100641)1.90613702
119Type I transferrin isoform profile (HP:0003642)1.89278379
120Abolished electroretinogram (ERG) (HP:0000550)1.89008176
121Limb dystonia (HP:0002451)1.86155030
122Gaze-evoked nystagmus (HP:0000640)1.85469595
123Blindness (HP:0000618)1.85372635
124Keratoconus (HP:0000563)1.84224460
125Increased corneal curvature (HP:0100692)1.84224460
126Secondary amenorrhea (HP:0000869)1.84139100
127Abnormal pupillary function (HP:0007686)1.83982838
128Aplastic anemia (HP:0001915)1.83489184
129Postaxial hand polydactyly (HP:0001162)1.83269398
130CNS hypomyelination (HP:0003429)1.83107395
131Abnormality of the renal cortex (HP:0011035)1.81900786
132Polyphagia (HP:0002591)1.81300312
133Aplasia/Hypoplasia involving the musculature (HP:0001460)1.80016184
134Oral leukoplakia (HP:0002745)1.79844638
135Tubular atrophy (HP:0000092)1.78986804
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78747718
137Woolly hair (HP:0002224)1.78740611
138Bifid tongue (HP:0010297)1.76906530
139Hypoplasia of the pons (HP:0012110)1.76082101
140Polyuria (HP:0000103)1.76022078
141Severe muscular hypotonia (HP:0006829)1.74232077
142Progressive inability to walk (HP:0002505)1.73886026
143Lissencephaly (HP:0001339)1.73126288
144Amblyopia (HP:0000646)1.73003142
145Renal tubular dysfunction (HP:0000124)1.72781900
146Medial flaring of the eyebrow (HP:0010747)1.71229683
147Dynein arm defect of respiratory motile cilia (HP:0012255)1.70937213
148Absent/shortened dynein arms (HP:0200106)1.70937213
149Abnormal urine phosphate concentration (HP:0012599)1.67232847
150Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.67211721
151Absent thumb (HP:0009777)1.65863946
152Stenosis of the external auditory canal (HP:0000402)1.65454178
153Hypothermia (HP:0002045)1.64154137
154Duplicated collecting system (HP:0000081)1.62328890
155Gliosis (HP:0002171)1.61754425
156Horseshoe kidney (HP:0000085)1.61214946
157Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.59501451
158Triphalangeal thumb (HP:0001199)1.58994051
159Multiple enchondromatosis (HP:0005701)1.58965158
160Abnormal ciliary motility (HP:0012262)1.58738663
161Cleft eyelid (HP:0000625)1.58539279
162Type 2 muscle fiber atrophy (HP:0003554)1.58036477
163Myokymia (HP:0002411)1.57521790
164Pancreatic fibrosis (HP:0100732)1.56083180
165External ophthalmoplegia (HP:0000544)1.55661606
166Patellar aplasia (HP:0006443)1.52639951
167Concave nail (HP:0001598)1.51999883
168Abnormal hemoglobin (HP:0011902)1.51593648
169Sparse eyelashes (HP:0000653)1.51222764
170Aplasia/Hypoplasia of the patella (HP:0006498)1.49565440
171Unsteady gait (HP:0002317)1.49396549
172Muscle fiber atrophy (HP:0100295)1.49092389
173Absent radius (HP:0003974)1.48445170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.24661718
2FRK4.11093622
3STK163.86064426
4BUB13.78974756
5NUAK13.65758518
6NME12.79795990
7WEE12.74970171
8PNCK2.65217874
9WNK32.61444650
10SRPK12.49312711
11VRK12.31538968
12GRK12.23696905
13EIF2AK12.15483111
14PLK42.09578988
15MUSK2.09507374
16TLK11.96664201
17VRK21.94865320
18TESK21.92788480
19IRAK31.92158640
20EIF2AK31.90055808
21MAP3K121.88815679
22MST41.86350570
23ARAF1.86199118
24LATS11.84285311
25STK31.77690238
26NTRK31.74665578
27LIMK11.72074278
28CASK1.65713632
29GRK51.62655480
30STK391.59394593
31MAP4K21.57286070
32PIM21.54675783
33PBK1.46794802
34MYLK1.45539508
35TSSK61.43135667
36DYRK21.39449162
37MAPKAPK51.30077302
38ADRBK21.26610602
39DAPK21.25041942
40TNIK1.24680323
41GRK71.24504298
42ZAK1.19529315
43INSRR1.17301121
44BRAF1.15893450
45TESK11.15760633
46DYRK31.15414091
47CDK191.10768359
48ABL21.08484087
49STK38L1.05222024
50MARK11.03893194
51BMPR1B1.03114279
52IRAK40.99935008
53OXSR10.99533754
54IRAK20.99328755
55AURKA0.97422203
56PRKCE0.95559921
57MKNK10.94244082
58PHKG20.93914774
59PHKG10.93914774
60CSNK1G30.93626730
61KDR0.92515618
62BCR0.91571202
63TAOK30.90998334
64PLK30.90314521
65PRKG20.90280552
66PRKCG0.87357089
67CDK30.86337678
68NEK20.86131893
69CDC70.84694395
70MAPK130.83498890
71PLK10.83355725
72IRAK10.83156484
73TEC0.82537144
74SIK20.81686403
75WNK40.79376682
76NTRK20.77644314
77RPS6KA50.76090275
78MAP3K40.75972714
79EIF2AK20.75403383
80CDK80.73120516
81CAMK2B0.72502474
82MKNK20.72042443
83EPHA20.71879440
84PINK10.71802607
85TRPM70.71686879
86OBSCN0.71673623
87DYRK1A0.71153612
88CSNK1G10.70705886
89PAK30.70042620
90CSNK2A10.68493359
91TXK0.68455905
92STK240.68003850
93TNK20.67464041
94BCKDK0.65822798
95CSNK2A20.64629342
96BMPR20.64145970
97PIK3CA0.61303780
98TIE10.61241307
99AURKB0.60759014
100SYK0.60064509
101DMPK0.59815036
102PAK10.58561761
103DAPK30.58214749
104PLK20.57891095
105BRSK20.57218926
106CCNB10.55341960
107CAMK2D0.54975932
108UHMK10.54781360
109WNK10.53555565
110RPS6KB20.52921425
111CDK70.52574007
112MAP2K70.52279225
113PRKCI0.52019361
114CHEK20.51607543
115CAMK2G0.49384337
116PRKCQ0.49247993
117TAOK10.49034920
118CAMK2A0.48512360
119PASK0.48025868
120ADRBK10.46186402
121LATS20.46138868
122PRKG10.45893359
123TTK0.44918648
124MAP3K110.44814884
125ERBB30.43508890
126AKT30.43366596
127PRKCZ0.43199421
128PIK3CG0.42715647
129FGFR20.42143143
130NEK60.42135219
131ACVR1B0.41548953
132CSNK1A10.41421531
133CDK90.41359414
134CAMK10.40750574
135MINK10.40605211
136CSNK1D0.40394011
137ILK0.38917996
138PTK2B0.38814231
139STK110.38196647
140CSNK1E0.37823162
141BLK0.37578246
142CDK50.36469046
143MAPK40.36379044
144MAP3K90.35563468
145PKN10.35526306
146ABL10.35097503
147CDK140.34972491
148PRKACA0.34960395
149MAPKAPK30.34778637
150CSNK1G20.34407553
151PDK30.34371555
152PDK40.34371555
153ROCK20.33006635
154CDK11A0.32114252

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.49177895
2Ribosome_Homo sapiens_hsa030105.41438399
3Parkinsons disease_Homo sapiens_hsa050124.71382038
4Proteasome_Homo sapiens_hsa030504.43591555
5RNA polymerase_Homo sapiens_hsa030204.18475027
6Huntingtons disease_Homo sapiens_hsa050163.59967160
7Alzheimers disease_Homo sapiens_hsa050103.44602872
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.94314013
9Protein export_Homo sapiens_hsa030602.64003741
10Pyrimidine metabolism_Homo sapiens_hsa002402.37591635
11Cardiac muscle contraction_Homo sapiens_hsa042602.27730848
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15780052
13Spliceosome_Homo sapiens_hsa030402.04950430
14Butanoate metabolism_Homo sapiens_hsa006502.02182099
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.97714016
16DNA replication_Homo sapiens_hsa030301.78861515
17Selenocompound metabolism_Homo sapiens_hsa004501.71324510
18Nitrogen metabolism_Homo sapiens_hsa009101.70814292
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.69491795
20Basal transcription factors_Homo sapiens_hsa030221.63691982
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58693666
22Nucleotide excision repair_Homo sapiens_hsa034201.57868075
23Mismatch repair_Homo sapiens_hsa034301.56004884
24Olfactory transduction_Homo sapiens_hsa047401.53397434
25Homologous recombination_Homo sapiens_hsa034401.53154542
26Caffeine metabolism_Homo sapiens_hsa002321.52786157
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50096848
28Morphine addiction_Homo sapiens_hsa050321.47754758
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39961383
30Purine metabolism_Homo sapiens_hsa002301.39833954
31RNA transport_Homo sapiens_hsa030131.35713918
32Type I diabetes mellitus_Homo sapiens_hsa049401.32889011
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32487196
34Collecting duct acid secretion_Homo sapiens_hsa049661.29594143
35GABAergic synapse_Homo sapiens_hsa047271.17163879
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16145027
37Fatty acid elongation_Homo sapiens_hsa000621.12626657
38Fanconi anemia pathway_Homo sapiens_hsa034601.12275123
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10591794
40RNA degradation_Homo sapiens_hsa030181.07181521
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.06822057
42Vitamin B6 metabolism_Homo sapiens_hsa007501.04150501
43Ovarian steroidogenesis_Homo sapiens_hsa049131.01667410
44Glutamatergic synapse_Homo sapiens_hsa047240.96556954
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94437124
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92709409
47Base excision repair_Homo sapiens_hsa034100.91507935
48Glutathione metabolism_Homo sapiens_hsa004800.87255238
49Metabolic pathways_Homo sapiens_hsa011000.87220319
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.84019689
51Circadian entrainment_Homo sapiens_hsa047130.79877516
52Sulfur relay system_Homo sapiens_hsa041220.79677544
53Arachidonic acid metabolism_Homo sapiens_hsa005900.79224431
54Folate biosynthesis_Homo sapiens_hsa007900.76876971
55Steroid biosynthesis_Homo sapiens_hsa001000.74220101
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71894955
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71026320
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69778063
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67754247
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66894641
61Vibrio cholerae infection_Homo sapiens_hsa051100.66143977
62Insulin secretion_Homo sapiens_hsa049110.66130749
63Non-homologous end-joining_Homo sapiens_hsa034500.65334794
64Linoleic acid metabolism_Homo sapiens_hsa005910.64473181
65Epstein-Barr virus infection_Homo sapiens_hsa051690.64134176
66Regulation of autophagy_Homo sapiens_hsa041400.63342505
67Ether lipid metabolism_Homo sapiens_hsa005650.58471773
68Cell cycle_Homo sapiens_hsa041100.57259945
69Arginine biosynthesis_Homo sapiens_hsa002200.56987578
70Phototransduction_Homo sapiens_hsa047440.56364563
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.55359954
72Rheumatoid arthritis_Homo sapiens_hsa053230.55127320
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53038864
74Sphingolipid metabolism_Homo sapiens_hsa006000.52512457
75ABC transporters_Homo sapiens_hsa020100.51789790
76Nicotine addiction_Homo sapiens_hsa050330.51405949
77Tyrosine metabolism_Homo sapiens_hsa003500.51148115
78Phenylalanine metabolism_Homo sapiens_hsa003600.50771695
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49642891
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45896009
81Sulfur metabolism_Homo sapiens_hsa009200.45029076
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44988895
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42148490
84Salivary secretion_Homo sapiens_hsa049700.42001639
85Tryptophan metabolism_Homo sapiens_hsa003800.41712972
86Long-term depression_Homo sapiens_hsa047300.39304366
87Pyruvate metabolism_Homo sapiens_hsa006200.38960506
88p53 signaling pathway_Homo sapiens_hsa041150.38489262
89Arginine and proline metabolism_Homo sapiens_hsa003300.38389896
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37863739
91Dopaminergic synapse_Homo sapiens_hsa047280.36918031
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36195635
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35178200
94Calcium signaling pathway_Homo sapiens_hsa040200.34993887
95Cholinergic synapse_Homo sapiens_hsa047250.34702659
96Graft-versus-host disease_Homo sapiens_hsa053320.33951946
97Pentose phosphate pathway_Homo sapiens_hsa000300.33625691
98Systemic lupus erythematosus_Homo sapiens_hsa053220.33555429
99Fat digestion and absorption_Homo sapiens_hsa049750.33045521
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32042993
101Dorso-ventral axis formation_Homo sapiens_hsa043200.31352945
102Serotonergic synapse_Homo sapiens_hsa047260.30793249
103Taste transduction_Homo sapiens_hsa047420.29888557
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29828754
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.28821094
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27522895
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.27334650
108Staphylococcus aureus infection_Homo sapiens_hsa051500.26711292
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26074519
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25783316
111Autoimmune thyroid disease_Homo sapiens_hsa053200.24062309
112Oocyte meiosis_Homo sapiens_hsa041140.24030476
113Synaptic vesicle cycle_Homo sapiens_hsa047210.23916262
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23570645
115mRNA surveillance pathway_Homo sapiens_hsa030150.23532512
116Asthma_Homo sapiens_hsa053100.23029139
117Allograft rejection_Homo sapiens_hsa053300.22982469
118Phagosome_Homo sapiens_hsa041450.21892176
119Histidine metabolism_Homo sapiens_hsa003400.19678991
120Fructose and mannose metabolism_Homo sapiens_hsa000510.19636841
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19372358
122Carbon metabolism_Homo sapiens_hsa012000.18194955
123Alcoholism_Homo sapiens_hsa050340.15681037
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.12406327
125Propanoate metabolism_Homo sapiens_hsa006400.12321479
126Peroxisome_Homo sapiens_hsa041460.12108075
127Chemical carcinogenesis_Homo sapiens_hsa052040.11728773
128One carbon pool by folate_Homo sapiens_hsa006700.11177753
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.11109235
130Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.05453647
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.05176601
132Retinol metabolism_Homo sapiens_hsa008300.04450758
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.03847509
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.03760053
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.03346530

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