USP51

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.17263709
2somite rostral/caudal axis specification (GO:0032525)6.99832859
3maintenance of protein location in nucleus (GO:0051457)6.33405673
4negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)6.22418566
5histone H4-K12 acetylation (GO:0043983)5.96727205
6negative regulation of epidermis development (GO:0045683)5.91903699
7negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.89961815
8regulation of mammary gland epithelial cell proliferation (GO:0033599)5.83928642
9regulation of telomere maintenance via telomerase (GO:0032210)5.58078212
10histone H4-K5 acetylation (GO:0043981)5.54830741
11histone H4-K8 acetylation (GO:0043982)5.54830741
12regulation of nuclear cell cycle DNA replication (GO:0033262)5.54677249
13regulation of response to osmotic stress (GO:0047484)5.43217259
14muscle organ morphogenesis (GO:0048644)5.42522095
15phenol-containing compound catabolic process (GO:0019336)5.36651158
16protein localization to kinetochore (GO:0034501)5.35200701
17negative regulation of cell cycle G2/M phase transition (GO:1902750)5.33967173
18regulation of cilium movement (GO:0003352)5.18688148
19response to dietary excess (GO:0002021)5.18237117
20primitive streak formation (GO:0090009)4.89345994
21negative regulation of telomerase activity (GO:0051974)4.81442450
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.81373832
23cardiovascular system development (GO:0072358)4.81290879
24rRNA transcription (GO:0009303)4.77511091
25cytidine deamination (GO:0009972)4.75805025
26cytidine metabolic process (GO:0046087)4.75805025
27cytidine catabolic process (GO:0006216)4.75805025
28regulation of apoptotic process involved in morphogenesis (GO:1902337)4.74544850
29hormone catabolic process (GO:0042447)4.74536580
30negative regulation of epidermal cell differentiation (GO:0045605)4.71249078
31regulation of MHC class I biosynthetic process (GO:0045343)4.56164441
32signal transduction involved in regulation of gene expression (GO:0023019)4.39513700
33notochord development (GO:0030903)4.31473182
34mitotic sister chromatid segregation (GO:0000070)4.28730379
35nucleoside transmembrane transport (GO:1901642)4.25975867
36negative regulation of telomere maintenance (GO:0032205)4.21716600
37heterochromatin organization (GO:0070828)4.19581980
38DNA double-strand break processing (GO:0000729)4.19502868
39maintenance of protein localization in organelle (GO:0072595)4.18727392
40kinetochore organization (GO:0051383)4.08809565
41microtubule severing (GO:0051013)4.07107504
42histone H4-K16 acetylation (GO:0043984)4.06371983
43coenzyme catabolic process (GO:0009109)4.04744422
44quinone metabolic process (GO:1901661)4.00315552
45rRNA methylation (GO:0031167)3.92169180
46epithelial cilium movement (GO:0003351)3.87178777
47chromatin remodeling at centromere (GO:0031055)3.83978559
48intestinal epithelial cell development (GO:0060576)3.80199703
49branching involved in mammary gland duct morphogenesis (GO:0060444)3.79272456
50kinetochore assembly (GO:0051382)3.78919871
51chromatin assembly (GO:0031497)3.77500123
52ventricular system development (GO:0021591)3.74615264
53protein localization to chromosome, centromeric region (GO:0071459)3.74532122
54DNA replication-dependent nucleosome assembly (GO:0006335)3.71007069
55DNA replication-dependent nucleosome organization (GO:0034723)3.71007069
56positive regulation of DNA-dependent DNA replication (GO:2000105)3.70217705
57regulation of translation in response to stress (GO:0043555)3.69200488
58establishment of protein localization to mitochondrial membrane (GO:0090151)3.64357093
59regulation of telomere maintenance (GO:0032204)3.62408353
60regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.61939273
61protein polyglutamylation (GO:0018095)3.60722621
62negative regulation of DNA-dependent DNA replication (GO:2000104)3.54923410
63cilium movement (GO:0003341)3.54864997
64sister chromatid segregation (GO:0000819)3.53996571
65negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.53921027
66nuclear pore complex assembly (GO:0051292)3.53057468
67CENP-A containing nucleosome assembly (GO:0034080)3.52376399
68DNA replication checkpoint (GO:0000076)3.52202837
69regulation of microtubule-based movement (GO:0060632)3.49047483
70cullin deneddylation (GO:0010388)3.47143106
71cell fate commitment involved in formation of primary germ layer (GO:0060795)3.47092456
72regulation of Golgi to plasma membrane protein transport (GO:0042996)3.44131983
73adaptation of signaling pathway (GO:0023058)3.42845027
74rRNA modification (GO:0000154)3.39734828
75pre-miRNA processing (GO:0031054)3.34437454
76GDP-mannose metabolic process (GO:0019673)3.34028713
77kidney morphogenesis (GO:0060993)3.32205255
78interferon-gamma production (GO:0032609)3.31679725
79tachykinin receptor signaling pathway (GO:0007217)3.31182672
80regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.31053850
81stress granule assembly (GO:0034063)3.28606712
82histone exchange (GO:0043486)3.27623571
83axonemal dynein complex assembly (GO:0070286)3.25264819
84pteridine-containing compound biosynthetic process (GO:0042559)3.24615018
85pyrimidine ribonucleoside catabolic process (GO:0046133)3.24038148
86thyroid hormone generation (GO:0006590)3.23769464
87water-soluble vitamin biosynthetic process (GO:0042364)3.19265691
88nuclear pore organization (GO:0006999)3.17668537
89regulation of translation, ncRNA-mediated (GO:0045974)3.17631309
90negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.17631309
91negative regulation of translation, ncRNA-mediated (GO:0040033)3.17631309
92cellular modified amino acid catabolic process (GO:0042219)3.17544465
93proline transport (GO:0015824)3.13903014
94intraciliary transport (GO:0042073)3.11238879
95anterior/posterior axis specification (GO:0009948)3.10952067
96calcium-mediated signaling using intracellular calcium source (GO:0035584)3.09519427
97regulation of glucokinase activity (GO:0033131)3.09025673
98regulation of hexokinase activity (GO:1903299)3.09025673
99regulation of telomerase activity (GO:0051972)3.08644781
100nephron epithelium morphogenesis (GO:0072088)3.06252063
101nephron tubule morphogenesis (GO:0072078)3.06252063
102positive regulation of histone H3-K4 methylation (GO:0051571)3.04068578
103negative regulation of bone resorption (GO:0045779)3.03407544
104intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.02244748
105vitamin A metabolic process (GO:0006776)3.02104875
106nucleoside transport (GO:0015858)3.00821045
107regulation of gene silencing by RNA (GO:0060966)2.99599184
108regulation of posttranscriptional gene silencing (GO:0060147)2.99599184
109regulation of gene silencing by miRNA (GO:0060964)2.99599184
110proteasome assembly (GO:0043248)2.97123533
111mitochondrion distribution (GO:0048311)2.96983825
112embryonic axis specification (GO:0000578)2.95628307
113protein deneddylation (GO:0000338)2.95626765
114negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.95105546
115mitochondrial respiratory chain complex assembly (GO:0033108)2.92000864
116axoneme assembly (GO:0035082)2.88627373
117positive regulation of protein deacetylation (GO:0090312)2.88289749
118positive regulation of histone deacetylation (GO:0031065)2.87823186
119cilium or flagellum-dependent cell motility (GO:0001539)2.87794241
120negative regulation of interleukin-2 production (GO:0032703)2.85593070
121negative regulation of smoothened signaling pathway (GO:0045879)2.85235894
122intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.84586132
123positive regulation of gluconeogenesis (GO:0045722)2.84163986
124bone trabecula formation (GO:0060346)2.84119487
125regulation of centriole replication (GO:0046599)2.80726624
126DNA damage response, detection of DNA damage (GO:0042769)2.79345440
127protein complex biogenesis (GO:0070271)2.78933290
128regulation of helicase activity (GO:0051095)2.77929570
129regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.76630786
130regulation of mitotic spindle checkpoint (GO:1903504)2.76630786
131presynaptic membrane assembly (GO:0097105)2.76346322
132anterior/posterior axis specification, embryo (GO:0008595)2.75753495
133response to pheromone (GO:0019236)2.75443363
134mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.68708167
135centriole replication (GO:0007099)2.68622019
136intra-S DNA damage checkpoint (GO:0031573)2.67574171
137replication fork processing (GO:0031297)2.65604369
138single strand break repair (GO:0000012)2.64838673
139recombinational repair (GO:0000725)2.62949664
140double-strand break repair via homologous recombination (GO:0000724)2.62503381
141DNA replication-independent nucleosome assembly (GO:0006336)2.60697701
142DNA replication-independent nucleosome organization (GO:0034724)2.60697701
143resolution of meiotic recombination intermediates (GO:0000712)2.59161986
144female gonad development (GO:0008585)2.58355187
145mitochondrial respiratory chain complex I assembly (GO:0032981)2.56429016
146NADH dehydrogenase complex assembly (GO:0010257)2.56429016
147mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.56429016
148regulation of mitochondrial translation (GO:0070129)2.54981243
149regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.54632081
150renal tubule morphogenesis (GO:0061333)2.50387733
151protein-cofactor linkage (GO:0018065)2.50123751
152regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.49213911
153protein neddylation (GO:0045116)2.48552290
154inositol phosphate catabolic process (GO:0071545)2.48027214
155mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.47366718
156inner mitochondrial membrane organization (GO:0007007)2.46554915
157platelet dense granule organization (GO:0060155)2.46053231
158maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.45549492
159presynaptic membrane organization (GO:0097090)2.43360016
160negative regulation of JUN kinase activity (GO:0043508)2.43357333
161mitotic G2/M transition checkpoint (GO:0044818)2.42283816
162respiratory chain complex IV assembly (GO:0008535)2.38564739
163telomere maintenance via telomerase (GO:0007004)2.38471235
164cilium organization (GO:0044782)2.38303648
165regulation of DNA endoreduplication (GO:0032875)2.37051333
166keratinocyte development (GO:0003334)2.36195676
167exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.36029827
168chaperone-mediated protein transport (GO:0072321)2.35711640
169nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.35319586
170DNA ligation (GO:0006266)2.35102071
171negative regulation of DNA recombination (GO:0045910)2.33959295
172signal peptide processing (GO:0006465)2.33198038
173regulation of acyl-CoA biosynthetic process (GO:0050812)2.32547890
174nonmotile primary cilium assembly (GO:0035058)2.32190560
175regulation of mesoderm development (GO:2000380)2.31662449
176photoreceptor cell maintenance (GO:0045494)2.31148364
177histone mRNA metabolic process (GO:0008334)2.30818221
178atrial cardiac muscle cell action potential (GO:0086014)2.30779203
179cilium assembly (GO:0042384)2.30031076
180L-ascorbic acid metabolic process (GO:0019852)2.25744200
181DNA catabolic process, exonucleolytic (GO:0000738)2.25127711
182synapsis (GO:0007129)2.24933906
183mitochondrial DNA replication (GO:0006264)2.24654879
184cell proliferation in forebrain (GO:0021846)2.24395624
185chemosensory behavior (GO:0007635)2.23811906
186histone H2A acetylation (GO:0043968)2.23383512
187phosphorylated carbohydrate dephosphorylation (GO:0046838)2.23107774
188daunorubicin metabolic process (GO:0044597)11.1889079
189polyketide metabolic process (GO:0030638)11.1889079
190doxorubicin metabolic process (GO:0044598)11.1889079

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.15360260
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse7.03973376
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse7.03973376
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse7.03973376
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.00145749
6E2F7_22180533_ChIP-Seq_HELA_Human3.95462703
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.54788444
8SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.09466811
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.00856651
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92597168
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.84381927
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.73038216
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.66934050
14TCF3_18692474_ChIP-Seq_MESCs_Mouse2.61588484
15ZNF274_21170338_ChIP-Seq_K562_Hela2.54401173
16FUS_26573619_Chip-Seq_HEK293_Human2.53807003
17SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.51406885
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.47873206
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46508781
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.34025369
21EWS_26573619_Chip-Seq_HEK293_Human2.33341084
22VDR_22108803_ChIP-Seq_LS180_Human2.28263414
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20416341
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.19693157
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15792902
26TCF3_18692474_ChIP-Seq_MEFs_Mouse2.13705959
27IRF1_19129219_ChIP-ChIP_H3396_Human2.11316470
28NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.07821006
29P300_19829295_ChIP-Seq_ESCs_Human2.04999547
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04407080
31NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.03567065
32EST1_17652178_ChIP-ChIP_JURKAT_Human2.03146672
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00343217
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.97488359
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97373883
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.91736915
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90979183
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.89471243
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.87535784
40GBX2_23144817_ChIP-Seq_PC3_Human1.84005826
41* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.82749686
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.82255592
43TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.79736770
44TAF15_26573619_Chip-Seq_HEK293_Human1.79472755
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.79380509
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79024808
47ELK1_19687146_ChIP-ChIP_HELA_Human1.71694527
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.71003565
49IGF1R_20145208_ChIP-Seq_DFB_Human1.64046059
50POU5F1_16518401_ChIP-PET_MESCs_Mouse1.63257045
51PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.61589793
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60937215
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59679273
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.57244331
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52745993
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51466119
57NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51025515
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49895264
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.45257807
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45085796
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44758480
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42807748
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42794725
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41580323
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.41388735
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39414867
67MYC_18940864_ChIP-ChIP_HL60_Human1.37870676
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37080638
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36610135
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34675968
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34073587
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33900115
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33239012
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33115178
75RNF2_27304074_Chip-Seq_NSC_Mouse1.31787691
76POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.30824448
77NANOG_16518401_ChIP-PET_MESCs_Mouse1.29171340
78FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28791973
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27997079
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27422881
81NANOG_18692474_ChIP-Seq_MESCs_Mouse1.26884124
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26440898
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26440898
84BCAT_22108803_ChIP-Seq_LS180_Human1.24962594
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23412041
86TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23029654
87SMAD4_21799915_ChIP-Seq_A2780_Human1.22411344
88ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22224820
89FOXM1_23109430_ChIP-Seq_U2OS_Human1.22050751
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21970506
91TBX3_20139965_ChIP-Seq_ESCs_Mouse1.21761314
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21339039
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20834266
94CBP_20019798_ChIP-Seq_JUKART_Human1.20834266
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20491117
96NANOG_21062744_ChIP-ChIP_HESCs_Human1.20407327
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20328577
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20043259
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19268476
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.18710611
101VDR_23849224_ChIP-Seq_CD4+_Human1.17877550
102KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17736529
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.17583086
104SOX2_18692474_ChIP-Seq_MESCs_Mouse1.15615608
105ER_23166858_ChIP-Seq_MCF-7_Human1.14207571
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.13659981
107YY1_21170310_ChIP-Seq_MESCs_Mouse1.13637878
108POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12952131
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12696012
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12345917
111IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12079591
112TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11976918
113MYC_18555785_ChIP-Seq_MESCs_Mouse1.10577124
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10566236
115AR_25329375_ChIP-Seq_VCAP_Human1.09422051
116NANOG_19829295_ChIP-Seq_ESCs_Human1.09255243
117SOX2_19829295_ChIP-Seq_ESCs_Human1.09255243
118FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08114493
119STAT3_23295773_ChIP-Seq_U87_Human1.07902549
120MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07888781
121TP53_22573176_ChIP-Seq_HFKS_Human1.07613266
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07411735
123STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06392710
124TCF4_23295773_ChIP-Seq_U87_Human1.05055909
125KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04566556
126NANOG_18692474_ChIP-Seq_MEFs_Mouse1.04429166
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04328372
128NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03879205
129TCF4_22108803_ChIP-Seq_LS180_Human1.02446761
130SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02346149
131ETS1_20019798_ChIP-Seq_JURKAT_Human1.02333918
132AR_21909140_ChIP-Seq_LNCAP_Human1.02151770
133RUNX2_22187159_ChIP-Seq_PCA_Human1.02090900
134PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01650666
135P53_22387025_ChIP-Seq_ESCs_Mouse1.01044561
136CDX2_20551321_ChIP-Seq_CACO-2_Human1.00623468
137NFE2_27457419_Chip-Seq_LIVER_Mouse1.00311974
138SOX2_16153702_ChIP-ChIP_HESCs_Human1.00075874
139P300_18555785_Chip-Seq_ESCs_Mouse0.98882025
140POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98683226
141YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98314454
142E2F1_18555785_Chip-Seq_ESCs_Mouse0.98009544
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97449048
144OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96952826
145FOXP3_21729870_ChIP-Seq_TREG_Human0.96430561
146CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96238379
147STAT3_18555785_Chip-Seq_ESCs_Mouse0.96073703
148FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95772000
149KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95290404
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95199631
151RING1B_27294783_Chip-Seq_NPCs_Mouse0.92747350
152MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90596083
153SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88891794
154TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88582784
155BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88543412
156GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88427672
157* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87054252
158MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.85679983
159SOX3_22085726_ChIP-Seq_NPCs_Mouse0.84186748
160STAT3_18555785_ChIP-Seq_MESCs_Mouse0.78820629
161TP53_20018659_ChIP-ChIP_R1E_Mouse0.78402552
162WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.77297424
163EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76358738
164KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.75718135
165STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.75503039
166MYC_18358816_ChIP-ChIP_MESCs_Mouse0.75322293
167PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74664524
168HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.73468689
169SMC4_20622854_ChIP-Seq_HELA_Human0.73251923
170MYC_22102868_ChIP-Seq_BL_Human0.72988026
171KAP1_27257070_Chip-Seq_ESCs_Mouse0.70867934
172SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.70337049
173SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.65052877
174CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.64737703
175FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.63503003
176SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.62831705
177NCOR1_26117541_ChIP-Seq_K562_Human0.62628005
178SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.62046795
179SALL1_21062744_ChIP-ChIP_HESCs_Human0.61882343

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.92696264
2MP0003122_maternal_imprinting4.70316712
3MP0004264_abnormal_extraembryonic_tissu4.25304424
4MP0003011_delayed_dark_adaptation4.07197176
5MP0003890_abnormal_embryonic-extraembry3.75264518
6MP0008877_abnormal_DNA_methylation3.56809288
7MP0003195_calcinosis3.29879063
8MP0005499_abnormal_olfactory_system3.27022248
9MP0005394_taste/olfaction_phenotype3.27022248
10MP0002254_reproductive_system_inflammat3.11233097
11MP0003136_yellow_coat_color3.08554836
12MP0003121_genomic_imprinting3.08165107
13MP0005257_abnormal_intraocular_pressure2.93854653
14MP0000678_abnormal_parathyroid_gland2.90233352
15MP0003183_abnormal_peptide_metabolism2.80499981
16MP0004858_abnormal_nervous_system2.74084222
17MP0008057_abnormal_DNA_replication2.58230253
18MP0000372_irregular_coat_pigmentation2.57547193
19MP0004043_abnormal_pH_regulation2.52221552
20MP0002653_abnormal_ependyma_morphology2.50075093
21MP0003283_abnormal_digestive_organ2.45743508
22MP0005075_abnormal_melanosome_morpholog2.40298577
23MP0003123_paternal_imprinting2.28172303
24MP0002877_abnormal_melanocyte_morpholog2.20780023
25MP0004957_abnormal_blastocyst_morpholog2.06531219
26MP0008961_abnormal_basal_metabolism1.97761045
27MP0002332_abnormal_exercise_endurance1.94396840
28MP0006035_abnormal_mitochondrial_morpho1.90081305
29MP0003938_abnormal_ear_development1.89696262
30MP0002837_dystrophic_cardiac_calcinosis1.87463900
31MP0003941_abnormal_skin_development1.84720747
32MP0008058_abnormal_DNA_repair1.77316327
33MP0001485_abnormal_pinna_reflex1.72916551
34MP0010094_abnormal_chromosome_stability1.72420369
35MP0010030_abnormal_orbit_morphology1.70097787
36MP0002277_abnormal_respiratory_mucosa1.65569157
37MP0001984_abnormal_olfaction1.64429720
38MP0001529_abnormal_vocalization1.61109671
39MP0004133_heterotaxia1.59325128
40MP0002751_abnormal_autonomic_nervous1.56062540
41MP0002127_abnormal_cardiovascular_syste1.52668007
42MP0003119_abnormal_digestive_system1.48434917
43MP0002090_abnormal_vision1.47158714
44MP0002909_abnormal_adrenal_gland1.45817274
45MP0002102_abnormal_ear_morphology1.45675522
46MP0003718_maternal_effect1.45627002
47MP0000049_abnormal_middle_ear1.44813708
48MP0006072_abnormal_retinal_apoptosis1.43721058
49MP0002932_abnormal_joint_morphology1.43122448
50MP0003693_abnormal_embryo_hatching1.40315262
51MP0001672_abnormal_embryogenesis/_devel1.39084403
52MP0005380_embryogenesis_phenotype1.39084403
53MP0008789_abnormal_olfactory_epithelium1.38299394
54MP0003787_abnormal_imprinting1.38201349
55MP0009046_muscle_twitch1.36693261
56MP0000569_abnormal_digit_pigmentation1.34146532
57MP0001293_anophthalmia1.33230319
58MP0005551_abnormal_eye_electrophysiolog1.31221761
59MP0003878_abnormal_ear_physiology1.30470168
60MP0005377_hearing/vestibular/ear_phenot1.30470168
61MP0001188_hyperpigmentation1.27883774
62MP0004270_analgesia1.27336516
63MP0002088_abnormal_embryonic_growth/wei1.27040593
64MP0004019_abnormal_vitamin_homeostasis1.26381768
65MP0005174_abnormal_tail_pigmentation1.25334035
66MP0003984_embryonic_growth_retardation1.24584484
67MP0002233_abnormal_nose_morphology1.21337884
68MP0000631_abnormal_neuroendocrine_gland1.21104529
69MP0005646_abnormal_pituitary_gland1.18531698
70MP0003567_abnormal_fetal_cardiomyocyte1.18310691
71MP0000428_abnormal_craniofacial_morphol1.17084321
72MP0001849_ear_inflammation1.16012102
73MP0003935_abnormal_craniofacial_develop1.15246675
74MP0002092_abnormal_eye_morphology1.14529888
75MP0000762_abnormal_tongue_morphology1.14520727
76MP0002114_abnormal_axial_skeleton1.14257875
77MP0001486_abnormal_startle_reflex1.13135711
78MP0003755_abnormal_palate_morphology1.11527982
79MP0002085_abnormal_embryonic_tissue1.10590577
80MP0003137_abnormal_impulse_conducting1.10452967
81MP0004885_abnormal_endolymph1.10209183
82MP0002084_abnormal_developmental_patter1.09273774
83MP0002734_abnormal_mechanical_nocicepti1.08776608
84MP0006276_abnormal_autonomic_nervous1.05552642
85MP0003880_abnormal_central_pattern1.05014630
86MP0004147_increased_porphyrin_level1.04187717
87MP0005266_abnormal_metabolism1.03124946
88MP0000350_abnormal_cell_proliferation1.02935900
89MP0002160_abnormal_reproductive_system1.01644530
90MP0005253_abnormal_eye_physiology1.01431968
91MP0001324_abnormal_eye_pigmentation1.01355590
92MP0005391_vision/eye_phenotype1.00862090
93MP0005367_renal/urinary_system_phenotyp0.99789897
94MP0000516_abnormal_urinary_system0.99789897
95MP0000432_abnormal_head_morphology0.98902990
96MP0002116_abnormal_craniofacial_bone0.98749423
97MP0005379_endocrine/exocrine_gland_phen0.98363641
98MP0003315_abnormal_perineum_morphology0.98025911
99MP0005248_abnormal_Harderian_gland0.95585394
100MP0009672_abnormal_birth_weight0.94998709
101MP0003186_abnormal_redox_activity0.94940688
102MP0002736_abnormal_nociception_after0.94453071
103MP0003111_abnormal_nucleus_morphology0.93807461
104MP0005408_hypopigmentation0.92558650
105MP0010352_gastrointestinal_tract_polyps0.92337624
106MP0002970_abnormal_white_adipose0.91168706
107MP0002697_abnormal_eye_size0.91109035
108MP0002086_abnormal_extraembryonic_tissu0.89818856
109MP0000647_abnormal_sebaceous_gland0.88571512
110MP0002557_abnormal_social/conspecific_i0.88521692
111MP0005084_abnormal_gallbladder_morpholo0.87081336
112MP0009697_abnormal_copulation0.86483351
113MP0009703_decreased_birth_body0.86139851
114MP0002272_abnormal_nervous_system0.85618235
115MP0005645_abnormal_hypothalamus_physiol0.83387813
116MP0005195_abnormal_posterior_eye0.82673415
117MP0001348_abnormal_lacrimal_gland0.81561132
118MP0000778_abnormal_nervous_system0.81445738
119MP0002822_catalepsy0.80577946
120MP0003705_abnormal_hypodermis_morpholog0.80039648
121MP0004215_abnormal_myocardial_fiber0.79154967
122MP0005389_reproductive_system_phenotype0.78644999
123MP0004085_abnormal_heartbeat0.77942447
124MP0002210_abnormal_sex_determination0.77374048
125MP0001270_distended_abdomen0.75301014
126MP0001929_abnormal_gametogenesis0.74283212
127MP0001944_abnormal_pancreas_morphology0.73099012
128MP0004197_abnormal_fetal_growth/weight/0.72637851
129MP0001145_abnormal_male_reproductive0.71937758
130MP0000653_abnormal_sex_gland0.71889091
131MP0002249_abnormal_larynx_morphology0.71263614
132MP0009745_abnormal_behavioral_response0.71180124
133MP0002139_abnormal_hepatobiliary_system0.70957949
134MP0005508_abnormal_skeleton_morphology0.69878992
135MP0003937_abnormal_limbs/digits/tail_de0.69407148
136MP0001697_abnormal_embryo_size0.68684625
137MP0002693_abnormal_pancreas_physiology0.67789804
138MP0006082_CNS_inflammation0.67696233
139MP0002098_abnormal_vibrissa_morphology0.66402693
140MP0003077_abnormal_cell_cycle0.66360703
141MP0003861_abnormal_nervous_system0.66333653
142MP0002081_perinatal_lethality0.61919618
143MP0000163_abnormal_cartilage_morphology0.61701700
144MP0002938_white_spotting0.61539844
145MP0000955_abnormal_spinal_cord0.61480140
146MP0002111_abnormal_tail_morphology0.60999098
147MP0000613_abnormal_salivary_gland0.60869652
148MP0001286_abnormal_eye_development0.59411935
149MP0003942_abnormal_urinary_system0.59241185
150MP0000313_abnormal_cell_death0.58456522
151MP0002752_abnormal_somatic_nervous0.58252833
152MP0008770_decreased_survivor_rate0.57072902
153MP0004142_abnormal_muscle_tone0.56864113
154MP0002269_muscular_atrophy0.56723586
155MP0001730_embryonic_growth_arrest0.55702109
156MP0002163_abnormal_gland_morphology0.55627842
157MP0002733_abnormal_thermal_nociception0.55624275
158MP0000358_abnormal_cell_content/0.55288422

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.39348537
2Hepatoblastoma (HP:0002884)5.43729467
3Hyperinsulinemic hypoglycemia (HP:0000825)5.39656592
4Hypochromic microcytic anemia (HP:0004840)5.20135053
5Rib fusion (HP:0000902)4.66851371
6Multiple enchondromatosis (HP:0005701)4.28166674
7Aplasia/Hypoplasia of the fovea (HP:0008060)4.25041351
8Hypoplasia of the fovea (HP:0007750)4.25041351
9Abnormality of the lower motor neuron (HP:0002366)3.99691733
10Ependymoma (HP:0002888)3.90487637
11Bifid tongue (HP:0010297)3.81123587
12Nephroblastoma (Wilms tumor) (HP:0002667)3.69889149
13Abnormality of the labia minora (HP:0012880)3.59520635
14Abnormality of the fovea (HP:0000493)3.56370550
15Embryonal renal neoplasm (HP:0011794)3.40769604
16Testicular atrophy (HP:0000029)3.27505927
17Rectovaginal fistula (HP:0000143)3.27255532
18Rectal fistula (HP:0100590)3.27255532
19Pancreatic fibrosis (HP:0100732)3.22776915
20Neoplasm of striated muscle (HP:0009728)3.18425655
21Dynein arm defect of respiratory motile cilia (HP:0012255)3.14727161
22Absent/shortened dynein arms (HP:0200106)3.14727161
23Abnormal respiratory epithelium morphology (HP:0012253)3.05609521
24Abnormal respiratory motile cilium morphology (HP:0005938)3.05609521
25Chromosomal breakage induced by crosslinking agents (HP:0003221)3.04415651
26Fused cervical vertebrae (HP:0002949)2.99573011
27Pancreatic cysts (HP:0001737)2.96133309
28Nephronophthisis (HP:0000090)2.95386499
29Abnormal ciliary motility (HP:0012262)2.94500184
30Intestinal fistula (HP:0100819)2.89413249
31Rhabdomyosarcoma (HP:0002859)2.88520782
32Vaginal fistula (HP:0004320)2.87491704
33Pancreatic islet-cell hyperplasia (HP:0004510)2.85048863
34Abnormality of the salivary glands (HP:0010286)2.83957709
35Partial duplication of thumb phalanx (HP:0009944)2.79944491
36Anomalous pulmonary venous return (HP:0010772)2.78481699
37True hermaphroditism (HP:0010459)2.77252973
38Abnormal respiratory motile cilium physiology (HP:0012261)2.76671358
39Amyotrophic lateral sclerosis (HP:0007354)2.73890720
40Hypomagnesemia (HP:0002917)2.70261637
41Ragged-red muscle fibers (HP:0003200)2.69081226
42Aplasia/hypoplasia of the humerus (HP:0006507)2.68920279
43Short humerus (HP:0005792)2.68614551
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.68113578
45Shawl scrotum (HP:0000049)2.66689732
46Molar tooth sign on MRI (HP:0002419)2.65694952
47Abnormality of midbrain morphology (HP:0002418)2.65694952
48Aplasia/Hypoplasia of the macula (HP:0008059)2.65117495
49Chromsome breakage (HP:0040012)2.64618527
50Astrocytoma (HP:0009592)2.64097917
51Abnormality of the astrocytes (HP:0100707)2.64097917
52Abnormal lung lobation (HP:0002101)2.63507678
53Osteomalacia (HP:0002749)2.61091855
54Horizontal nystagmus (HP:0000666)2.57657683
55Acute necrotizing encephalopathy (HP:0006965)2.55770953
56Rhinitis (HP:0012384)2.53885680
57Intestinal atresia (HP:0011100)2.51619115
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.51189629
59Acute encephalopathy (HP:0006846)2.50108585
60Abnormality of the renal medulla (HP:0100957)2.44788748
61Aplasia/Hypoplasia affecting the retina (HP:0008061)2.44053361
62Abnormality of glycolipid metabolism (HP:0010969)2.43512588
63Abnormality of liposaccharide metabolism (HP:0010968)2.43512588
64Abnormality of glycosphingolipid metabolism (HP:0004343)2.43512588
65Chronic hepatic failure (HP:0100626)2.42517995
66Partial duplication of the phalanx of hand (HP:0009999)2.42108825
67Hypoglycemic coma (HP:0001325)2.40636128
68Supernumerary spleens (HP:0009799)2.39133068
69Abnormality of chromosome segregation (HP:0002916)2.38914899
70Neoplasm of the heart (HP:0100544)2.35272063
71Septo-optic dysplasia (HP:0100842)2.34856757
72Generalized hypotonia (HP:0001290)2.32820997
73Progressive macrocephaly (HP:0004481)2.32481679
74Hyperventilation (HP:0002883)2.32148543
75Microvesicular hepatic steatosis (HP:0001414)2.31527430
76Abnormal cartilage morphology (HP:0002763)2.30680127
77Abnormality of the pulmonary veins (HP:0011718)2.29435554
78Anophthalmia (HP:0000528)2.29086025
79Preauricular pit (HP:0004467)2.28238015
80Periauricular skin pits (HP:0100277)2.28238015
81Abnormality of endocrine pancreas physiology (HP:0012093)2.27257661
82Abnormality of the pancreatic islet cells (HP:0006476)2.27257661
83Pendular nystagmus (HP:0012043)2.26628189
84Abnormality of abdominal situs (HP:0011620)2.26601755
85Abdominal situs inversus (HP:0003363)2.26601755
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.26132939
87Abnormality of the intrinsic pathway (HP:0010989)2.25789404
88Progressive muscle weakness (HP:0003323)2.25086821
89Abnormality of small intestinal villus morphology (HP:0011472)2.24854416
90Villous atrophy (HP:0011473)2.24854416
91Reduced antithrombin III activity (HP:0001976)2.23381303
92Hyperglycinemia (HP:0002154)2.19104996
93Abnormal pancreas size (HP:0012094)2.18949114
94Neoplasm of the adrenal cortex (HP:0100641)2.18798305
95Aqueductal stenosis (HP:0002410)2.18345113
96Colon cancer (HP:0003003)2.17009169
97Renal duplication (HP:0000075)2.16496732
98Methylmalonic acidemia (HP:0002912)2.16165200
99Abnormality of the phalanges of the hallux (HP:0010057)2.15944048
100Type I transferrin isoform profile (HP:0003642)2.14033257
101Impulsivity (HP:0100710)2.14011559
102Medial flaring of the eyebrow (HP:0010747)2.13839318
103Facial cleft (HP:0002006)2.12621091
104Preauricular skin tag (HP:0000384)2.11909052
105Sclerocornea (HP:0000647)2.11831224
106Trismus (HP:0000211)2.11697373
107Gout (HP:0001997)2.10207425
108Hypoglycemic seizures (HP:0002173)2.10108064
109Sensory axonal neuropathy (HP:0003390)2.08808044
110Resting tremor (HP:0002322)2.08331877
111Adrenal hypoplasia (HP:0000835)2.08269711
112Skin nodule (HP:0200036)2.06176952
113Spinal muscular atrophy (HP:0007269)2.05931792
114Abolished electroretinogram (ERG) (HP:0000550)2.05404052
115Aplasia/Hypoplasia of the spleen (HP:0010451)2.05115073
116Abnormality of the pubic bones (HP:0003172)2.05041776
117Meckel diverticulum (HP:0002245)2.04308034
118Symptomatic seizures (HP:0011145)2.04241421
119Tongue fasciculations (HP:0001308)2.02324457
120Pseudobulbar signs (HP:0002200)2.02106269
121Atrophy/Degeneration involving motor neurons (HP:0007373)2.01181853
122Abnormality of chromosome stability (HP:0003220)1.99469613
123Large for gestational age (HP:0001520)1.98752117
124Hypothermia (HP:0002045)1.97945301
125Methylmalonic aciduria (HP:0012120)1.97738685
126Nasolacrimal duct obstruction (HP:0000579)1.97636578
127Neoplasm of the adrenal gland (HP:0100631)1.97205209
128Chronic bronchitis (HP:0004469)1.96889809
129Male pseudohermaphroditism (HP:0000037)1.96529145
130Glioma (HP:0009733)1.95648746
131Abnormality of the ileum (HP:0001549)1.94898429
132Volvulus (HP:0002580)1.94157130
133Ectopic kidney (HP:0000086)1.94056783
134Abnormal mitochondria in muscle tissue (HP:0008316)1.93820767
135Abnormal drinking behavior (HP:0030082)1.93041765
136Polydipsia (HP:0001959)1.93041765
137Genital tract atresia (HP:0001827)1.92637500
138Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92363855
139Cystic liver disease (HP:0006706)1.92193482
140Vaginal atresia (HP:0000148)1.91706608
141Skin pits (HP:0100276)1.91455424
142Embryonal neoplasm (HP:0002898)1.90333002
143Missing ribs (HP:0000921)1.89614667
144Hypopigmentation of the fundus (HP:0007894)1.89550180
145Asplenia (HP:0001746)1.88903565
146Malignant neoplasm of the central nervous system (HP:0100836)1.88347008
147Short 5th finger (HP:0009237)1.88191693
148Amblyopia (HP:0000646)1.87756375
149Tented upper lip vermilion (HP:0010804)1.86365987
150Aplasia/Hypoplasia of the sternum (HP:0006714)1.86104555
151Tetraplegia (HP:0002445)1.85062083
152Abnormality of magnesium homeostasis (HP:0004921)1.84459512
153Skin tags (HP:0010609)1.82274617
154Ectopic anus (HP:0004397)1.81565823
155Increased CSF lactate (HP:0002490)1.80933402
156Postaxial foot polydactyly (HP:0001830)1.80193239
157Median cleft lip (HP:0000161)1.79420455
158Anencephaly (HP:0002323)1.77955503
159Abnormality of the metopic suture (HP:0005556)1.76249610
160Abnormal biliary tract physiology (HP:0012439)1.75658248
161Bile duct proliferation (HP:0001408)1.75658248
162Labial hypoplasia (HP:0000066)1.73969912
163Tubular atrophy (HP:0000092)1.73779220
164Preaxial hand polydactyly (HP:0001177)1.73463541
165Bronchiectasis (HP:0002110)1.72525192
166Mitochondrial inheritance (HP:0001427)1.71164268
167Aplasia/Hypoplasia of the tongue (HP:0010295)1.71106208
168Scrotal hypoplasia (HP:0000046)1.70556525
169Congenital primary aphakia (HP:0007707)1.69322779
170Renal hypoplasia (HP:0000089)1.69294369
171Fair hair (HP:0002286)1.69220700
172Megaloblastic anemia (HP:0001889)1.69205630
173Gastrointestinal atresia (HP:0002589)1.67699160
174Hypoplastic female external genitalia (HP:0012815)1.67380811
175Congenital, generalized hypertrichosis (HP:0004540)1.66584699
176Absent eyebrow (HP:0002223)1.65781679
177Abnormal sex determination (HP:0012244)1.64171652

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.88947346
2GRK55.46075399
3ERN14.46582889
4GRK64.08935476
5ADRBK23.42931714
6FRK3.24405974
7GRK13.21407876
8TSSK63.12353627
9TNIK2.97977942
10PNCK2.96193512
11MAP3K42.50093808
12MKNK22.48408307
13GRK72.47662333
14NTRK12.45795291
15CSF1R2.39207338
16ACVR1B2.37554917
17TYRO32.31629042
18TTK2.28972832
19PLK32.15206382
20TGFBR22.13975997
21WEE12.12131788
22MOS2.11824907
23TRIM282.10929278
24WNK12.07698600
25MATK2.01749896
26MST41.99586076
27FGFR21.96850487
28MAP2K71.94307784
29ZAK1.92572434
30MAPK71.91356654
31BMPR1B1.89324558
32HIPK21.82215898
33PLK41.80780421
34PINK11.71675172
35MKNK11.69052753
36CASK1.67513296
37NUAK11.61918000
38NTRK31.55614732
39TAF11.51702681
40STK101.47980717
41VRK21.40150197
42PRKG21.36146329
43EEF2K1.34442889
44VRK11.33696157
45CDK71.33618626
46MARK21.32445544
47MAP2K41.26460777
48NEK21.24483099
49TIE11.24124883
50WNK31.21662230
51CAMK41.19699960
52PLK21.19378990
53ADRBK11.17290735
54CHEK21.17144203
55EIF2AK31.17110035
56NLK1.16897522
57MAP4K21.12834987
58MAPK151.10028913
59INSRR1.08659419
60MAPKAPK51.05692899
61CSNK1G11.02472253
62AKT31.01876225
63CSNK1G21.01600924
64EPHA20.97604327
65MAPKAPK30.97194053
66NEK10.96115003
67MAPK130.95632717
68PLK10.93845004
69CDK30.89883476
70STK30.87417190
71STK160.86042477
72TAOK20.83855127
73MAP2K60.82074625
74PASK0.82031941
75PRPF4B0.81712095
76BUB10.80172946
77EPHA40.79139727
78ATR0.76920305
79OXSR10.75509822
80CHEK10.71893484
81PTK20.69769070
82KSR10.68073925
83RPS6KB20.67565646
84FGFR30.66483119
85MAP3K100.66196294
86MAP3K120.65997883
87MAP3K60.65729144
88PRKCE0.65300252
89PDGFRA0.65193524
90AKT20.63400959
91CDC70.62143746
92MAP3K90.61834040
93STK390.60865996
94LATS20.60755745
95STK240.60553536
96PAK40.60359699
97YES10.58977083
98NTRK20.57223000
99PRKD30.56991885
100MUSK0.56227633
101ERBB20.55476188
102CSNK1G30.55111620
103IGF1R0.53021187
104DYRK1A0.52978277
105ALK0.52579717
106CSK0.51999546
107DMPK0.50398898
108PRKCI0.49976835
109DYRK30.48344721
110SIK30.48234660
111MTOR0.48021104
112MAP3K20.47521141
113MINK10.46928940
114PRKD20.46301105
115BRSK10.45378485
116PDK20.45082423
117CDK20.44094419
118TGFBR10.43560935
119CCNB10.42306863
120PBK0.42278777
121EIF2AK20.42090683
122BRD40.41293563
123CSNK1E0.40958008
124ATM0.39324233
125ITK0.37883293
126CAMK1G0.37497673
127MAPK100.37234564
128CSNK1A10.36831676
129PAK30.36489618
130TEC0.36170340
131FGFR10.35674636
132CSNK2A20.34867468
133CSNK2A10.34496490
134MAP3K70.34406069
135PRKDC0.34387970
136UHMK10.33602689
137FLT30.33309699
138CSNK1D0.32822441
139DAPK20.32475269
140IRAK20.32408761
141RIPK10.31599778
142PRKACB0.31418708
143AURKA0.31093766
144WNK40.29498392
145CDK10.28819722
146CDK180.27279637
147DYRK20.27244832
148GSK3B0.27090895
149PRKACA0.26756855
150DYRK1B0.26527350
151MAPK140.26500655
152PRKACG0.25805695
153BCR0.25613745
154CDK150.25589507
155NME10.23052614
156AURKB0.22674052
157MAPK120.22172626
158STK38L0.21848690
159PRKCG0.21637604
160CDK11A0.20844440
161PRKCD0.20486540
162PRKAA10.19495565
163STK380.19096509
164RPS6KA30.18640077
165CDC42BPA0.18523984
166SRPK10.17455745
167BRSK20.16503139
168CDK140.16078038
169KSR20.15872680

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.95453717
2Vitamin B6 metabolism_Homo sapiens_hsa007504.81316845
3Maturity onset diabetes of the young_Homo sapiens_hsa049504.25623411
4Fructose and mannose metabolism_Homo sapiens_hsa000512.93922557
5Galactose metabolism_Homo sapiens_hsa000522.90008585
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86324220
7Oxidative phosphorylation_Homo sapiens_hsa001902.62409984
8Steroid biosynthesis_Homo sapiens_hsa001002.30947776
9Parkinsons disease_Homo sapiens_hsa050122.11296233
10Linoleic acid metabolism_Homo sapiens_hsa005912.08754702
11Arachidonic acid metabolism_Homo sapiens_hsa005902.07917765
12Vitamin digestion and absorption_Homo sapiens_hsa049772.05861704
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04619029
14Protein export_Homo sapiens_hsa030601.94837536
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.92475262
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.89813609
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.88750256
18Propanoate metabolism_Homo sapiens_hsa006401.81411121
19Proteasome_Homo sapiens_hsa030501.79665288
20Huntingtons disease_Homo sapiens_hsa050161.75162566
21Thyroid cancer_Homo sapiens_hsa052161.62523705
22Phototransduction_Homo sapiens_hsa047441.58512489
23Other glycan degradation_Homo sapiens_hsa005111.58459293
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57686038
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.57283884
26Taste transduction_Homo sapiens_hsa047421.56118183
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52858163
28Butanoate metabolism_Homo sapiens_hsa006501.47805240
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.47199682
30Fanconi anemia pathway_Homo sapiens_hsa034601.41079888
31Fatty acid elongation_Homo sapiens_hsa000621.40209548
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39856959
33mTOR signaling pathway_Homo sapiens_hsa041501.37850536
34Ovarian steroidogenesis_Homo sapiens_hsa049131.35362273
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.31408351
36mRNA surveillance pathway_Homo sapiens_hsa030151.26479655
37Cardiac muscle contraction_Homo sapiens_hsa042601.25042668
38Alzheimers disease_Homo sapiens_hsa050101.25036602
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.23739566
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.23536761
41Nucleotide excision repair_Homo sapiens_hsa034201.23301610
42Insulin secretion_Homo sapiens_hsa049111.21988625
43Base excision repair_Homo sapiens_hsa034101.20992793
44RNA degradation_Homo sapiens_hsa030181.20700056
45RNA transport_Homo sapiens_hsa030131.20511565
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18238012
47Peroxisome_Homo sapiens_hsa041461.16714587
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11943657
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11627443
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09337732
51Nicotine addiction_Homo sapiens_hsa050331.08972303
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08749291
53Ether lipid metabolism_Homo sapiens_hsa005651.06112723
54Inositol phosphate metabolism_Homo sapiens_hsa005621.06093566
55Pyruvate metabolism_Homo sapiens_hsa006201.04144684
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03493936
57Serotonergic synapse_Homo sapiens_hsa047261.03291473
58Collecting duct acid secretion_Homo sapiens_hsa049661.01428902
59Folate biosynthesis_Homo sapiens_hsa007901.00638930
60Sulfur metabolism_Homo sapiens_hsa009200.97524203
61Glutathione metabolism_Homo sapiens_hsa004800.97096787
62Purine metabolism_Homo sapiens_hsa002300.95790213
63GABAergic synapse_Homo sapiens_hsa047270.94793273
64Regulation of autophagy_Homo sapiens_hsa041400.92594932
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92567426
66Cell cycle_Homo sapiens_hsa041100.91767211
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91360644
68Basal cell carcinoma_Homo sapiens_hsa052170.90917487
69Retinol metabolism_Homo sapiens_hsa008300.90653164
70Homologous recombination_Homo sapiens_hsa034400.90397025
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.87542992
72Hedgehog signaling pathway_Homo sapiens_hsa043400.86393937
73Ribosome_Homo sapiens_hsa030100.86391252
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83022872
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82158914
76Choline metabolism in cancer_Homo sapiens_hsa052310.81851652
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81831198
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80685078
79Long-term potentiation_Homo sapiens_hsa047200.80274666
80Nitrogen metabolism_Homo sapiens_hsa009100.79626934
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78557991
82Mismatch repair_Homo sapiens_hsa034300.76995959
83Fatty acid metabolism_Homo sapiens_hsa012120.75787251
84beta-Alanine metabolism_Homo sapiens_hsa004100.75365281
85One carbon pool by folate_Homo sapiens_hsa006700.74333298
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73761471
87Fatty acid degradation_Homo sapiens_hsa000710.72986003
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72910248
89Metabolic pathways_Homo sapiens_hsa011000.72224461
90Long-term depression_Homo sapiens_hsa047300.71296425
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70068272
92Non-homologous end-joining_Homo sapiens_hsa034500.68951452
93Chemical carcinogenesis_Homo sapiens_hsa052040.68881689
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66922475
95Glutamatergic synapse_Homo sapiens_hsa047240.66817130
96GnRH signaling pathway_Homo sapiens_hsa049120.65573918
97Pyrimidine metabolism_Homo sapiens_hsa002400.63238474
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62349971
99Wnt signaling pathway_Homo sapiens_hsa043100.62119455
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.61779432
101Caffeine metabolism_Homo sapiens_hsa002320.61439842
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.57444019
103Tryptophan metabolism_Homo sapiens_hsa003800.56501448
104RNA polymerase_Homo sapiens_hsa030200.56374822
105p53 signaling pathway_Homo sapiens_hsa041150.55998728
106Fat digestion and absorption_Homo sapiens_hsa049750.55933054
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54747879
108N-Glycan biosynthesis_Homo sapiens_hsa005100.54560209
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53719166
110TGF-beta signaling pathway_Homo sapiens_hsa043500.53693657
111Bladder cancer_Homo sapiens_hsa052190.53615884
112Lysine degradation_Homo sapiens_hsa003100.53420089
113MicroRNAs in cancer_Homo sapiens_hsa052060.53343612
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51757875
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.49862347
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49558007
117Circadian rhythm_Homo sapiens_hsa047100.49434313
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49135422
119Pathways in cancer_Homo sapiens_hsa052000.48525666
120cAMP signaling pathway_Homo sapiens_hsa040240.46920053
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46251192
122Tight junction_Homo sapiens_hsa045300.45566835
123Selenocompound metabolism_Homo sapiens_hsa004500.45515085
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45304100
125Spliceosome_Homo sapiens_hsa030400.44145790
126Rap1 signaling pathway_Homo sapiens_hsa040150.43178157
127AMPK signaling pathway_Homo sapiens_hsa041520.43038596
128Hippo signaling pathway_Homo sapiens_hsa043900.42786090
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42530963
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.42259404
131Olfactory transduction_Homo sapiens_hsa047400.41690041
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41676435
133Non-small cell lung cancer_Homo sapiens_hsa052230.40144106
134Oocyte meiosis_Homo sapiens_hsa041140.39201961
135Morphine addiction_Homo sapiens_hsa050320.38951144
136Basal transcription factors_Homo sapiens_hsa030220.38799280
137DNA replication_Homo sapiens_hsa030300.38672500
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37555170
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37015096
140Dorso-ventral axis formation_Homo sapiens_hsa043200.36968285
141Dopaminergic synapse_Homo sapiens_hsa047280.36001063
142Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35604447
143Ras signaling pathway_Homo sapiens_hsa040140.34167964
144Type I diabetes mellitus_Homo sapiens_hsa049400.34068101
145Glucagon signaling pathway_Homo sapiens_hsa049220.33335192
146Type II diabetes mellitus_Homo sapiens_hsa049300.32572968
147Prion diseases_Homo sapiens_hsa050200.32067285
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27955321
149Calcium signaling pathway_Homo sapiens_hsa040200.23544489
150Cocaine addiction_Homo sapiens_hsa050300.23158422
151Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21862090
152Insulin resistance_Homo sapiens_hsa049310.21748824
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21243441
154PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18806853
155Melanogenesis_Homo sapiens_hsa049160.18357672

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