USP53

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)8.30844100
2polyketide metabolic process (GO:0030638)8.30844100
3doxorubicin metabolic process (GO:0044598)8.30844100
4aminoglycoside antibiotic metabolic process (GO:0030647)5.17999091
5endocardial cushion development (GO:0003197)5.17809499
6regulation of calcineurin-NFAT signaling cascade (GO:0070884)5.02707498
7response to pheromone (GO:0019236)4.78519610
8detection of molecule of bacterial origin (GO:0032490)4.64258688
9collagen fibril organization (GO:0030199)4.41313661
10pericardium development (GO:0060039)4.30504908
11sequestering of extracellular ligand from receptor (GO:0035581)4.05682181
12G-protein coupled receptor internalization (GO:0002031)3.91214631
13sulfate transmembrane transport (GO:1902358)3.85405749
14mesenchymal-epithelial cell signaling (GO:0060638)3.78383759
15cell migration involved in heart development (GO:0060973)3.78008203
16smooth muscle tissue development (GO:0048745)3.70047656
17skin morphogenesis (GO:0043589)3.62834830
18type B pancreatic cell proliferation (GO:0044342)3.59367477
19metanephric mesenchyme development (GO:0072075)3.58355342
20energy homeostasis (GO:0097009)3.51434119
21positive regulation of heat generation (GO:0031652)3.49578742
22anterior/posterior axis specification, embryo (GO:0008595)3.47232722
23chondrocyte proliferation (GO:0035988)3.43803351
24blood vessel maturation (GO:0001955)3.40199778
25positive regulation of cellular amide metabolic process (GO:0034250)3.39972473
26fibroblast migration (GO:0010761)3.39240265
27kidney mesenchyme development (GO:0072074)3.36767745
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.36431321
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.36431321
30regulation of translation, ncRNA-mediated (GO:0045974)3.36431321
31extracellular matrix assembly (GO:0085029)3.35447779
32protein heterotrimerization (GO:0070208)3.34777651
33auditory receptor cell stereocilium organization (GO:0060088)3.33926347
34regulation of fever generation (GO:0031620)3.32713326
35sulfate transport (GO:0008272)3.32621467
36glomerular basement membrane development (GO:0032836)3.19031099
37hypotonic response (GO:0006971)3.17888930
38hemidesmosome assembly (GO:0031581)3.17394497
39cell adhesion mediated by integrin (GO:0033627)3.16699052
40detection of external biotic stimulus (GO:0098581)3.16081655
41endodermal cell differentiation (GO:0035987)3.15320914
42regulation of heat generation (GO:0031650)3.14876334
43positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.12218390
44regulation of keratinocyte proliferation (GO:0010837)3.05149794
45regulation of non-canonical Wnt signaling pathway (GO:2000050)3.04070857
46negative regulation of axon extension involved in axon guidance (GO:0048843)3.04029374
47actin-mediated cell contraction (GO:0070252)3.03773707
48glomerulus development (GO:0032835)3.03064599
49ovulation from ovarian follicle (GO:0001542)3.01657186
50negative regulation of fatty acid transport (GO:2000192)3.00552560
51ventricular septum development (GO:0003281)2.98972785
52endothelial cell morphogenesis (GO:0001886)2.98459332
53mesenchymal cell differentiation (GO:0048762)2.96517643
54cell migration involved in sprouting angiogenesis (GO:0002042)2.95167522
55regulation of somitogenesis (GO:0014807)2.94844755
56protein localization to cell surface (GO:0034394)2.93904688
57inner ear receptor stereocilium organization (GO:0060122)2.93455930
58negative regulation of smooth muscle cell migration (GO:0014912)2.92000490
59regulation of transforming growth factor beta2 production (GO:0032909)2.91968494
60regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.91895693
61regulation of transforming growth factor beta1 production (GO:0032908)2.91868136
62embryonic cranial skeleton morphogenesis (GO:0048701)2.90605008
63chondrocyte development (GO:0002063)2.88409702
64regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.88316602
65substrate adhesion-dependent cell spreading (GO:0034446)2.87572456
66endocrine hormone secretion (GO:0060986)2.87023927
67cardiac myofibril assembly (GO:0055003)2.86586324
68bone trabecula formation (GO:0060346)2.86070663
69lung lobe morphogenesis (GO:0060463)2.82772589
70regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.82400607
71regulation of pigment cell differentiation (GO:0050932)2.82238361
72positive regulation of endothelial cell apoptotic process (GO:2000353)2.81248407
73cellular anion homeostasis (GO:0030002)2.81183566
74face morphogenesis (GO:0060325)2.80208869
75cell-substrate junction assembly (GO:0007044)2.79818887
76lymphangiogenesis (GO:0001946)2.79664843
77myofibril assembly (GO:0030239)2.79637213
78mesenchymal cell differentiation involved in renal system development (GO:2001012)2.78448392
79mesenchymal cell differentiation involved in kidney development (GO:0072161)2.78448392
80histone H3-K4 trimethylation (GO:0080182)2.78198939
81negative regulation of keratinocyte proliferation (GO:0010839)2.77021515
82detection of biotic stimulus (GO:0009595)2.76676026
83atrioventricular valve morphogenesis (GO:0003181)2.74858280
84neural crest cell development (GO:0014032)2.74737254
85vascular endothelial growth factor signaling pathway (GO:0038084)2.73377641
86wound healing, spreading of epidermal cells (GO:0035313)2.72669020
87retina vasculature morphogenesis in camera-type eye (GO:0061299)2.71887648
88hippo signaling (GO:0035329)2.71565890
89cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.70686591
90actin-myosin filament sliding (GO:0033275)2.70421656
91muscle filament sliding (GO:0030049)2.70421656
92insulin-like growth factor receptor signaling pathway (GO:0048009)2.69553802
93plasma membrane repair (GO:0001778)2.68382695
94positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.67073405
95cellular response to vitamin (GO:0071295)2.66864781
96regulation of organ formation (GO:0003156)2.66012594
97embryonic camera-type eye morphogenesis (GO:0048596)2.64323374
98cell differentiation involved in metanephros development (GO:0072202)2.64080687
99regulation of cardiac muscle hypertrophy (GO:0010611)2.63823754
100bone remodeling (GO:0046849)2.60917100
101positive regulation of p38MAPK cascade (GO:1900745)2.60061853
102regulation of muscle hypertrophy (GO:0014743)2.56919611
103regulation of timing of cell differentiation (GO:0048505)2.56405740
104negative regulation of protein localization to cell surface (GO:2000009)2.56274257
105positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.56014863
106nodal signaling pathway (GO:0038092)2.55879807
107RNA destabilization (GO:0050779)2.55853988
108sarcomere organization (GO:0045214)2.55720669
109positive regulation of astrocyte differentiation (GO:0048711)2.55664136
110actin filament-based movement (GO:0030048)2.55570985
111drinking behavior (GO:0042756)2.54587450
112regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.54106244
113regulation of the force of heart contraction (GO:0002026)2.54013242
114positive regulation of fibroblast migration (GO:0010763)2.50845353
115extracellular negative regulation of signal transduction (GO:1900116)2.49045276
116extracellular regulation of signal transduction (GO:1900115)2.49045276
117regulation of integrin-mediated signaling pathway (GO:2001044)2.48913052
118platelet-derived growth factor receptor signaling pathway (GO:0048008)2.47585274
119mesonephros development (GO:0001823)2.47460530
120lateral sprouting from an epithelium (GO:0060601)2.47203310
121positive regulation of prostaglandin secretion (GO:0032308)2.46595303
122embryonic process involved in female pregnancy (GO:0060136)2.46546415
123collagen metabolic process (GO:0032963)2.46181179
124artery development (GO:0060840)2.46000066
125regulation of germinal center formation (GO:0002634)2.45720931
126negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.45543022
127cardiac septum development (GO:0003279)2.45489653
128kidney morphogenesis (GO:0060993)2.44959565
129female gonad development (GO:0008585)2.43972079
130import into cell (GO:0098657)2.43942851
131positive regulation of macrophage activation (GO:0043032)2.43826479
132negative regulation of systemic arterial blood pressure (GO:0003085)2.43620090
133UDP-N-acetylglucosamine metabolic process (GO:0006047)2.43277063
134neuron remodeling (GO:0016322)2.43004051
135interleukin-6-mediated signaling pathway (GO:0070102)2.42413352
136DNA methylation involved in gamete generation (GO:0043046)2.42135257
137lateral ventricle development (GO:0021670)2.41999486
138negative regulation of cardiac muscle tissue development (GO:0055026)2.41321058
139paraxial mesoderm development (GO:0048339)2.41302823
140substrate-dependent cell migration (GO:0006929)2.41012146
141positive regulation of blood vessel endothelial cell migration (GO:0043536)2.40858721
142prostate gland growth (GO:0060736)2.40829081
143presynaptic membrane assembly (GO:0097105)2.40719710
144positive regulation of neurological system process (GO:0031646)2.40500056
145negative regulation of axon guidance (GO:1902668)2.40433964
146positive regulation of icosanoid secretion (GO:0032305)2.40412369
147monocyte chemotaxis (GO:0002548)2.39795452
148estrogen biosynthetic process (GO:0006703)2.39746441
149glomerular visceral epithelial cell development (GO:0072015)2.39262174
150muscle cell migration (GO:0014812)2.39253250
151regulation of myoblast differentiation (GO:0045661)2.39155755
152negative regulation of BMP signaling pathway (GO:0030514)2.37290228
153developmental pigmentation (GO:0048066)2.35764609
154cranial nerve structural organization (GO:0021604)2.35306762
155positive regulation of respiratory burst (GO:0060267)2.34612884
156negative regulation of osteoblast proliferation (GO:0033689)2.33555407
157regulation of activation of Janus kinase activity (GO:0010533)2.32026631
158histone H3-K9 modification (GO:0061647)2.30646401
159phosphate ion homeostasis (GO:0055062)2.30439061
160trivalent inorganic anion homeostasis (GO:0072506)2.30439061
161positive regulation of interleukin-1 beta secretion (GO:0050718)2.29218810
162specification of organ identity (GO:0010092)2.28024360
163ganglion development (GO:0061548)2.27246095
164positive regulation of uterine smooth muscle contraction (GO:0070474)2.25292012
165desmosome organization (GO:0002934)2.24992267
166regulation of cell proliferation involved in kidney development (GO:1901722)2.22761652
167maintenance of gastrointestinal epithelium (GO:0030277)2.20996714
168nucleotide transmembrane transport (GO:1901679)2.20965570
169regulation of development, heterochronic (GO:0040034)2.20001284
170embryonic forelimb morphogenesis (GO:0035115)2.19966549
171antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.19916969
172regulation of interleukin-8 secretion (GO:2000482)2.19915620
173positive regulation of interleukin-1 secretion (GO:0050716)2.19560645
174regulation of prostaglandin secretion (GO:0032306)2.18817383
175replicative senescence (GO:0090399)2.18713189
176positive regulation of meiosis (GO:0045836)2.18545662
177superoxide anion generation (GO:0042554)2.17004420
178bicarbonate transport (GO:0015701)2.16953178
179microglial cell activation (GO:0001774)2.15293694
180postsynaptic membrane organization (GO:0001941)2.15000320
181head development (GO:0060322)2.14903430
182cell differentiation involved in kidney development (GO:0061005)2.14672770
183macrophage activation (GO:0042116)2.14449852
184regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.14278035
185regulation of mitotic spindle checkpoint (GO:1903504)2.14261430
186regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.14261430
187positive regulation of fatty acid transport (GO:2000193)2.12602046
188cartilage morphogenesis (GO:0060536)2.12173656
189regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.11116946
190negative regulation of stem cell proliferation (GO:2000647)2.09851208
191negative regulation of mast cell activation (GO:0033004)2.08665576
192somatic stem cell division (GO:0048103)2.08574274
193regulation of glomerulus development (GO:0090192)2.07615578
194regulation of icosanoid secretion (GO:0032303)2.06403631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.75019434
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.00630081
3EZH2_22144423_ChIP-Seq_EOC_Human2.81051074
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61486032
5EP300_21415370_ChIP-Seq_HL-1_Mouse2.60402387
6CJUN_26792858_Chip-Seq_BT549_Human2.54248861
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.46281146
8BRD4_25478319_ChIP-Seq_HGPS_Human2.45072618
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36329962
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33749942
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27200869
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.26213971
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.26002050
14NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.24365349
15NRF2_20460467_ChIP-Seq_MEFs_Mouse2.24365349
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.18771149
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.18370135
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.14137431
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.13685666
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.11419697
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10234697
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06363997
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.99755922
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.98212554
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.98015017
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94415973
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.93150024
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92016410
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.86449646
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.86098049
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.83608218
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.83537563
33* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82032687
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.81109388
35TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.80516344
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80310287
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80225519
38AHR_22903824_ChIP-Seq_MCF-7_Human1.79711383
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79051597
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.78733693
41P300_19829295_ChIP-Seq_ESCs_Human1.78267605
42IGF1R_20145208_ChIP-Seq_DFB_Human1.78168801
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.77675058
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.73897510
45SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.73897510
46E2F1_18555785_Chip-Seq_ESCs_Mouse1.71714581
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71354225
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.66634285
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65827015
50* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.65409853
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.63738586
52FOXM1_26456572_ChIP-Seq_MCF-7_Human1.63487017
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61321157
54P53_22387025_ChIP-Seq_ESCs_Mouse1.58139936
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.57299933
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56275296
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56265131
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.55362276
59SUZ12_18555785_Chip-Seq_ESCs_Mouse1.54947010
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54831500
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.54339431
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54126453
63SMAD4_21799915_ChIP-Seq_A2780_Human1.53932754
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52450438
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52353273
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51573720
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51387138
68STAT3_18555785_Chip-Seq_ESCs_Mouse1.49988705
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.48627222
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.48623571
71FUS_26573619_Chip-Seq_HEK293_Human1.47168964
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.46304393
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45410947
74RNF2_27304074_Chip-Seq_NSC_Mouse1.45023123
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.44630451
76NMYC_18555785_Chip-Seq_ESCs_Mouse1.44447897
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.43932265
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43588756
79STAT3_23295773_ChIP-Seq_U87_Human1.43520243
80OCT4_18555785_Chip-Seq_ESCs_Mouse1.43104285
81RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42975839
82EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42975839
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42453990
84P300_18555785_Chip-Seq_ESCs_Mouse1.40944505
85* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40114590
86* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.39699778
87TAF15_26573619_Chip-Seq_HEK293_Human1.39504912
88SOX2_18555785_Chip-Seq_ESCs_Mouse1.38715107
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38047933
90AR_21572438_ChIP-Seq_LNCaP_Human1.37910925
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.37861967
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37152433
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36727360
94EWS_26573619_Chip-Seq_HEK293_Human1.36497019
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.36267980
96TP53_16413492_ChIP-PET_HCT116_Human1.36182666
97ER_23166858_ChIP-Seq_MCF-7_Human1.35463378
98JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34412715
99RUNX1_27457419_Chip-Seq_LIVER_Mouse1.33682273
100TP53_18474530_ChIP-ChIP_U2OS_Human1.33242695
101TP63_23658742_ChIP-Seq_EP156T_Human1.31647142
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31515494
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31515494
104VDR_22108803_ChIP-Seq_LS180_Human1.30851311
105FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30615156
106RXR_22108803_ChIP-Seq_LS180_Human1.30539690
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30045493
108ZFX_18555785_Chip-Seq_ESCs_Mouse1.29996686
109AR_25329375_ChIP-Seq_VCAP_Human1.29444802
110RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29134915
111Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28453082
112PU1_27457419_Chip-Seq_LIVER_Mouse1.27469934
113SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26609934
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25294616
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25281981
116TCF4_23295773_ChIP-Seq_U87_Human1.25066641
117KLF4_18555785_Chip-Seq_ESCs_Mouse1.25035465
118CLOCK_20551151_ChIP-Seq_293T_Human1.24371774
119* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24310760
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23523672
121CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23304387
122* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.22718939
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22571335
124NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22449511
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22316709
126TCF4_18268006_ChIP-ChIP_LS174T_Human1.22005143
127RUNX2_22187159_ChIP-Seq_PCA_Human1.21818791
128PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.20377400
129POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20245206
130MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.19960786
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19133112
132CTCF_18555785_Chip-Seq_ESCs_Mouse1.18752904
133SOX2_20726797_ChIP-Seq_SW620_Human1.18643737
134FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18514726
135OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17789976
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17365484
137CDX2_22108803_ChIP-Seq_LS180_Human1.17078596
138OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15398080
139TBX20_22080862_ChIP-Seq_HEART_Mouse1.15180065
140TBX20_22328084_ChIP-Seq_HEART_Mouse1.15180065
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14982452
142DROSHA_22980978_ChIP-Seq_HELA_Human1.14549156
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14137513
144BCAT_22108803_ChIP-Seq_LS180_Human1.11858523
145P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11803685
146CRX_20693478_ChIP-Seq_RETINA_Mouse1.11781371
147CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11537526
148SMAD1_18555785_Chip-Seq_ESCs_Mouse1.11476028
149HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10973547
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09958423
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08233098
152PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07352301
153NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06321038
154BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06115242
155* SMAD3_21741376_ChIP-Seq_HESCs_Human1.02830198
156* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98671895
157NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96611803
158HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96407765
159* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90948502
160WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90441489
161ISL1_27105846_Chip-Seq_CPCs_Mouse0.90183934
162TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89278519

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.17254781
2MP0000566_synostosis4.53925579
3MP0005275_abnormal_skin_tensile4.31581697
4MP0004272_abnormal_basement_membrane3.87642401
5MP0006292_abnormal_olfactory_placode3.71295757
6MP0005377_hearing/vestibular/ear_phenot3.52925871
7MP0003878_abnormal_ear_physiology3.52925871
8MP0005257_abnormal_intraocular_pressure3.35039357
9MP0002277_abnormal_respiratory_mucosa3.34314317
10MP0003279_aneurysm3.34304297
11MP0003136_yellow_coat_color3.33222611
12MP0003950_abnormal_plasma_membrane3.28255884
13MP0003705_abnormal_hypodermis_morpholog3.09318387
14MP0006054_spinal_hemorrhage3.08655542
15MP0001188_hyperpigmentation3.07384935
16MP0001958_emphysema2.97896880
17MP0008004_abnormal_stomach_pH2.77532683
18MP0003941_abnormal_skin_development2.70998525
19MP0000751_myopathy2.54356368
20MP0005645_abnormal_hypothalamus_physiol2.47670996
21MP0005646_abnormal_pituitary_gland2.39644147
22MP0005171_absent_coat_pigmentation2.39603682
23MP0010352_gastrointestinal_tract_polyps2.29653851
24MP0010368_abnormal_lymphatic_system2.23698605
25MP0002108_abnormal_muscle_morphology2.23526663
26MP0005409_darkened_coat_color2.21381418
27MP0009697_abnormal_copulation2.18771301
28MP0001346_abnormal_lacrimal_gland2.15548021
29MP0001542_abnormal_bone_strength2.05821081
30MP0003566_abnormal_cell_adhesion2.02611869
31MP0004084_abnormal_cardiac_muscle1.94592305
32MP0005023_abnormal_wound_healing1.92285329
33MP0004381_abnormal_hair_follicle1.91338249
34MP0002938_white_spotting1.88243203
35MP0001986_abnormal_taste_sensitivity1.84422441
36MP0004036_abnormal_muscle_relaxation1.84292769
37MP0000749_muscle_degeneration1.83777357
38MP0003091_abnormal_cell_migration1.75503878
39MP0000767_abnormal_smooth_muscle1.74408099
40MP0004742_abnormal_vestibular_system1.69075980
41MP0000383_abnormal_hair_follicle1.67063991
42MP0000569_abnormal_digit_pigmentation1.64297587
43MP0001486_abnormal_startle_reflex1.64074337
44MP0002163_abnormal_gland_morphology1.63683257
45MP0000013_abnormal_adipose_tissue1.62005320
46MP0002060_abnormal_skin_morphology1.61952118
47MP0009250_abnormal_appendicular_skeleto1.59641325
48MP0005423_abnormal_somatic_nervous1.58142416
49MP0005623_abnormal_meninges_morphology1.58114821
50MP0002295_abnormal_pulmonary_circulatio1.54631907
51MP0000049_abnormal_middle_ear1.51285196
52MP0000678_abnormal_parathyroid_gland1.47630619
53MP0005379_endocrine/exocrine_gland_phen1.44610176
54MP0000372_irregular_coat_pigmentation1.41749797
55MP0002009_preneoplasia1.38267500
56MP0002638_abnormal_pupillary_reflex1.35934278
57MP0000015_abnormal_ear_pigmentation1.35200326
58MP0000613_abnormal_salivary_gland1.34153211
59MP0005620_abnormal_muscle_contractility1.34146720
60MP0002102_abnormal_ear_morphology1.33917977
61MP0003868_abnormal_feces_composition1.33848894
62MP0002249_abnormal_larynx_morphology1.32422783
63MP0003045_fibrosis1.32212164
64MP0001879_abnormal_lymphatic_vessel1.31863853
65MP0001485_abnormal_pinna_reflex1.30617032
66MP0003787_abnormal_imprinting1.28179768
67MP0000733_abnormal_muscle_development1.27774329
68MP0002998_abnormal_bone_remodeling1.27153768
69MP0000681_abnormal_thyroid_gland1.26944161
70MP0001661_extended_life_span1.24698243
71MP0000759_abnormal_skeletal_muscle1.24181897
72MP0002896_abnormal_bone_mineralization1.23542810
73MP0004087_abnormal_muscle_fiber1.22469752
74MP0005595_abnormal_vascular_smooth1.21443207
75MP0001299_abnormal_eye_distance/1.17220593
76MP0003879_abnormal_hair_cell1.16329495
77MP0000750_abnormal_muscle_regeneration1.16213214
78MP0002177_abnormal_outer_ear1.14441091
79MP0001501_abnormal_sleep_pattern1.13285028
80MP0002396_abnormal_hematopoietic_system1.12239547
81MP0005369_muscle_phenotype1.11520729
82MP0003646_muscle_fatigue1.11156632
83MP0003937_abnormal_limbs/digits/tail_de1.09931841
84MP0002233_abnormal_nose_morphology1.09861735
85MP0004233_abnormal_muscle_weight1.08947850
86MP0000534_abnormal_ureter_morphology1.08763552
87MP0004145_abnormal_muscle_electrophysio1.08704195
88MP0001243_abnormal_dermal_layer1.06555099
89MP0002168_other_aberrant_phenotype1.05675722
90MP0003938_abnormal_ear_development1.04586560
91MP0005330_cardiomyopathy1.04187901
92MP0005310_abnormal_salivary_gland1.03464199
93MP0004484_altered_response_of1.02366043
94MP0000432_abnormal_head_morphology1.01492290
95MP0002877_abnormal_melanocyte_morpholog1.00053437
96MP0001963_abnormal_hearing_physiology0.99932912
97MP0005503_abnormal_tendon_morphology0.99807541
98MP0002876_abnormal_thyroid_physiology0.99329893
99MP0006138_congestive_heart_failure0.98906445
100MP0005164_abnormal_response_to0.98325063
101MP0002128_abnormal_blood_circulation0.98281658
102MP0002269_muscular_atrophy0.96997659
103MP0000762_abnormal_tongue_morphology0.96850433
104MP0002557_abnormal_social/conspecific_i0.96817774
105MP0008775_abnormal_heart_ventricle0.96233590
106MP0002109_abnormal_limb_morphology0.95506460
107MP0004215_abnormal_myocardial_fiber0.95483233
108MP0002098_abnormal_vibrissa_morphology0.95442303
109MP0000026_abnormal_inner_ear0.95276549
110MP0004130_abnormal_muscle_cell0.95189047
111MP0002116_abnormal_craniofacial_bone0.93849530
112MP0000003_abnormal_adipose_tissue0.93056822
113MP0002972_abnormal_cardiac_muscle0.92693711
114MP0001348_abnormal_lacrimal_gland0.92240293
115MP0005174_abnormal_tail_pigmentation0.89634173
116MP0002095_abnormal_skin_pigmentation0.89096643
117MP0003755_abnormal_palate_morphology0.88519241
118MP0005508_abnormal_skeleton_morphology0.88197353
119MP0005187_abnormal_penis_morphology0.88145328
120MP0001851_eye_inflammation0.87485839
121MP0000631_abnormal_neuroendocrine_gland0.86653607
122MP0003942_abnormal_urinary_system0.86270355
123MP0000428_abnormal_craniofacial_morphol0.86092404
124MP0001324_abnormal_eye_pigmentation0.84914851
125MP0001919_abnormal_reproductive_system0.84449124
126MP0002106_abnormal_muscle_physiology0.84275302
127MP0002127_abnormal_cardiovascular_syste0.84115522
128MP0004134_abnormal_chest_morphology0.83998133
129MP0008995_early_reproductive_senescence0.83703619
130MP0005647_abnormal_sex_gland0.82746244
131MP0009384_cardiac_valve_regurgitation0.82677480
132MP0002113_abnormal_skeleton_development0.82623007
133MP0000163_abnormal_cartilage_morphology0.82552212
134MP0001440_abnormal_grooming_behavior0.82338349
135MP0000538_abnormal_urinary_bladder0.81711071
136MP0005390_skeleton_phenotype0.80956012
137MP0002115_abnormal_skeleton_extremities0.80647381
138MP0001664_abnormal_digestion0.79899758
139MP0006276_abnormal_autonomic_nervous0.79664432
140MP0009780_abnormal_chondrocyte_physiolo0.79125879
141MP0005075_abnormal_melanosome_morpholog0.78510224
142MP0010386_abnormal_urinary_bladder0.77790311
143MP0002925_abnormal_cardiovascular_devel0.77771974
144MP0002254_reproductive_system_inflammat0.77333703
145MP0005197_abnormal_uvea_morphology0.76895924
146MP0003828_pulmonary_edema0.76021567
147MP0009053_abnormal_anal_canal0.75880065
148MP0000747_muscle_weakness0.75594369
149MP0001614_abnormal_blood_vessel0.75387771
150MP0001186_pigmentation_phenotype0.74613445
151MP0010678_abnormal_skin_adnexa0.74553204
152MP0002332_abnormal_exercise_endurance0.74550738
153MP0002160_abnormal_reproductive_system0.74183248
154MP0003283_abnormal_digestive_organ0.73828933
155MP0000427_abnormal_hair_cycle0.73638254
156MP0001502_abnormal_circadian_rhythm0.72129122
157MP0000470_abnormal_stomach_morphology0.70553191
158MP0003935_abnormal_craniofacial_develop0.70406049
159MP0002933_joint_inflammation0.69575237
160MP0005388_respiratory_system_phenotype0.67928982
161MP0002133_abnormal_respiratory_system0.67928982
162MP0010630_abnormal_cardiac_muscle0.67817316
163MP0001119_abnormal_female_reproductive0.67746752
164MP0003880_abnormal_central_pattern0.67675597
165MP0002075_abnormal_coat/hair_pigmentati0.66749908
166MP0003936_abnormal_reproductive_system0.66496631
167MP0000467_abnormal_esophagus_morphology0.66337077
168MP0000462_abnormal_digestive_system0.66243848
169MP0005551_abnormal_eye_electrophysiolog0.66032087
170MP0003385_abnormal_body_wall0.65913234
171MP0001286_abnormal_eye_development0.64937119
172MP0005248_abnormal_Harderian_gland0.62455741
173MP0005389_reproductive_system_phenotype0.62172211
174MP0000627_abnormal_mammary_gland0.61204572

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)5.84017449
2Premature rupture of membranes (HP:0001788)5.57304325
3Protrusio acetabuli (HP:0003179)5.54797987
4Type 1 muscle fiber predominance (HP:0003803)5.28390202
5Aortic dissection (HP:0002647)5.05092632
6Vascular tortuosity (HP:0004948)4.52280614
7Nemaline bodies (HP:0003798)4.02747766
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.89916078
9Arterial tortuosity (HP:0005116)3.87365040
10Muscle fiber inclusion bodies (HP:0100299)3.83547163
11Parakeratosis (HP:0001036)3.83111953
12Prostate neoplasm (HP:0100787)3.62875836
13Absent eyebrow (HP:0002223)3.55384518
14Soft skin (HP:0000977)3.52051657
15Atrophic scars (HP:0001075)3.40432010
16Neonatal short-limb short stature (HP:0008921)3.35500828
17Cheilitis (HP:0100825)3.25054066
18Spinal rigidity (HP:0003306)3.19740617
19Unilateral renal agenesis (HP:0000122)3.19685902
20Broad metatarsal (HP:0001783)3.18548791
21Patchy hypopigmentation of hair (HP:0011365)3.10861754
22Absent/shortened dynein arms (HP:0200106)3.09375518
23Dynein arm defect of respiratory motile cilia (HP:0012255)3.09375518
24Abnormality of incisor morphology (HP:0011063)3.08527220
25Chromosomal breakage induced by crosslinking agents (HP:0003221)3.07651821
26Overgrowth (HP:0001548)3.00320103
27Ankle contracture (HP:0006466)2.96775876
28Congenital sensorineural hearing impairment (HP:0008527)2.96088672
29Sparse lateral eyebrow (HP:0005338)2.94718662
30White forelock (HP:0002211)2.90219057
31Alopecia of scalp (HP:0002293)2.87273680
32Chronic hepatic failure (HP:0100626)2.86484061
33Round ear (HP:0100830)2.82140160
34Aplasia of the musculature (HP:0100854)2.82130462
35Chromsome breakage (HP:0040012)2.82070373
36Cervical subluxation (HP:0003308)2.81970546
37Follicular hyperkeratosis (HP:0007502)2.81908766
38Osteomalacia (HP:0002749)2.81052543
39Bladder diverticulum (HP:0000015)2.77677820
40Wormian bones (HP:0002645)2.74132884
41Hyporeflexia of lower limbs (HP:0002600)2.74091858
42Abnormality of dental color (HP:0011073)2.72756582
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.71267788
44Osteolytic defects of the hand bones (HP:0009699)2.71267788
45Hyperphosphatemia (HP:0002905)2.69829467
46Mitral valve prolapse (HP:0001634)2.69173425
47Febrile seizures (HP:0002373)2.68278212
48Dilatation of the ascending aorta (HP:0005111)2.66956585
49Mildly elevated creatine phosphokinase (HP:0008180)2.63929186
50Abnormality of the calf musculature (HP:0001430)2.59143024
51Fragile skin (HP:0001030)2.58555353
52Increased variability in muscle fiber diameter (HP:0003557)2.55176052
53Abnormality of the nasal septum (HP:0000419)2.53964601
54Hip contracture (HP:0003273)2.46149455
55Aplasia cutis congenita (HP:0001057)2.45942368
56Aneurysm (HP:0002617)2.45413103
57Shallow orbits (HP:0000586)2.44504595
58Abnormal ciliary motility (HP:0012262)2.42111821
59Lip pit (HP:0100267)2.39744185
60Aortic regurgitation (HP:0001659)2.37116129
61Cardiovascular calcification (HP:0011915)2.35853858
62Tetraparesis (HP:0002273)2.35675248
63Hypoplasia of the iris (HP:0007676)2.34817539
64Slender build (HP:0001533)2.34742502
65Abnormality of the frontal sinuses (HP:0002687)2.33901422
66Wide anterior fontanel (HP:0000260)2.33531708
67Increased connective tissue (HP:0009025)2.30912673
68Abnormality of skeletal muscle fiber size (HP:0012084)2.30297637
69Renal dysplasia (HP:0000110)2.29840056
70Hyperaldosteronism (HP:0000859)2.29454627
71Abnormality of proline metabolism (HP:0010907)2.28771601
72Hydroxyprolinuria (HP:0003080)2.28771601
73Coronal craniosynostosis (HP:0004440)2.28047323
74Right ventricular cardiomyopathy (HP:0011663)2.26192723
75Recurrent corneal erosions (HP:0000495)2.23499957
76Abnormality of calcium-phosphate metabolism (HP:0100530)2.23048580
77Pancreatic fibrosis (HP:0100732)2.22736641
78Hyperactive renin-angiotensin system (HP:0000841)2.22553032
79Septo-optic dysplasia (HP:0100842)2.22248881
80Mesomelia (HP:0003027)2.22131118
81Metabolic alkalosis (HP:0200114)2.21788382
82Ectropion (HP:0000656)2.21131101
83Exercise-induced myalgia (HP:0003738)2.19200871
84Blue sclerae (HP:0000592)2.18573401
85True hermaphroditism (HP:0010459)2.17251127
86Absent eyelashes (HP:0000561)2.17054532
87Popliteal pterygium (HP:0009756)2.15237967
88Absent frontal sinuses (HP:0002688)2.12803833
89Bundle branch block (HP:0011710)2.11850666
90Elbow flexion contracture (HP:0002987)2.11352185
91Alveolar cell carcinoma (HP:0006519)2.11074378
92Abnormality of dentin (HP:0010299)2.10881949
93Neck muscle weakness (HP:0000467)2.08684840
94Conical tooth (HP:0000698)2.07693353
95Mitral stenosis (HP:0001718)2.07459947
96Narrow palate (HP:0000189)2.06518830
97Distal lower limb muscle weakness (HP:0009053)2.06099509
98Joint laxity (HP:0001388)2.06096570
99Cerebral aneurysm (HP:0004944)2.05990439
100Syringomyelia (HP:0003396)2.05761195
101Spinal cord lesions (HP:0100561)2.05761195
102Abnormal delivery (HP:0001787)2.05199696
103Lipoatrophy (HP:0100578)2.03680564
104Abnormality of molar (HP:0011077)2.03427604
105Abnormality of molar morphology (HP:0011070)2.03427604
106Persistence of primary teeth (HP:0006335)2.00166163
107Hypoplasia of the fovea (HP:0007750)1.99643768
108Aplasia/Hypoplasia of the fovea (HP:0008060)1.99643768
109Muscle fiber splitting (HP:0003555)1.99092907
110Ectopic kidney (HP:0000086)1.98849094
111Oligodontia (HP:0000677)1.98529041
112Ulnar bowing (HP:0003031)1.97618640
113Aortic valve stenosis (HP:0001650)1.97571207
114Tarsal synostosis (HP:0008368)1.96376930
115Abnormality of the columella (HP:0009929)1.96325813
116Abnormality of the right ventricle (HP:0001707)1.96300769
117Ulnar deviation of the wrist (HP:0003049)1.96005438
118Abnormality of the acetabulum (HP:0003170)1.95882367
119Calf muscle hypertrophy (HP:0008981)1.95632241
120Neoplasm of the tracheobronchial system (HP:0100552)1.95330841
121Peritonitis (HP:0002586)1.95061884
122Striae distensae (HP:0001065)1.94966473
123Corneal dystrophy (HP:0001131)1.94826740
124Aplasia involving bones of the extremities (HP:0009825)1.93414927
125Aplasia involving bones of the upper limbs (HP:0009823)1.93414927
126Aplasia of the phalanges of the hand (HP:0009802)1.93414927
127Knee flexion contracture (HP:0006380)1.92233889
128Abnormality of the dental pulp (HP:0006479)1.90049865
129Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.89515798
130Genu recurvatum (HP:0002816)1.89453989
131Tubulointerstitial nephritis (HP:0001970)1.89436731
132Muscle hypertrophy of the lower extremities (HP:0008968)1.89396288
133Cutaneous finger syndactyly (HP:0010554)1.88484373
134Median cleft lip (HP:0000161)1.87795907
135Abnormal respiratory motile cilium physiology (HP:0012261)1.87653610
136Abnormality of the renal medulla (HP:0100957)1.87406874
137Scapular winging (HP:0003691)1.87087556
138Abnormality of permanent molar morphology (HP:0011071)1.86877892
139Abnormality of the dental root (HP:0006486)1.86877892
140Taurodontia (HP:0000679)1.86877892
141Hyperextensible skin (HP:0000974)1.86380084
142Mitral regurgitation (HP:0001653)1.86339611
143Stomach cancer (HP:0012126)1.84882013
144Natal tooth (HP:0000695)1.83670601
145Decreased central vision (HP:0007663)1.83337174
146Bowel diverticulosis (HP:0005222)1.83118930
147Short middle phalanx of the 5th finger (HP:0004220)1.83038442
148Ulnar claw (HP:0001178)1.82628709
149Abnormality of chloride homeostasis (HP:0011422)1.82117962
150Increased number of teeth (HP:0011069)1.82093417
151Cutaneous syndactyly (HP:0012725)1.81607420
152Infantile muscular hypotonia (HP:0008947)1.80084948
153Absent hair (HP:0002298)1.79580755
154Tetany (HP:0001281)1.79428118
155Bilateral sensorineural hearing impairment (HP:0008619)1.78266646
156Abnormality of the parietal bone (HP:0002696)1.78257085
157Nonprogressive disorder (HP:0003680)1.77743839
158Abnormal respiratory epithelium morphology (HP:0012253)1.77153319
159Abnormal respiratory motile cilium morphology (HP:0005938)1.77153319
160Bradycardia (HP:0001662)1.77120842
161Widely spaced teeth (HP:0000687)1.76743845
162Abnormality of carpal bone ossification (HP:0006257)1.76692432
163Asymmetric septal hypertrophy (HP:0001670)1.74863971
164Craniofacial hyperostosis (HP:0004493)1.73879147
165Synostosis involving bones of the lower limbs (HP:0009138)1.73745311
166Synostosis involving bones of the feet (HP:0009140)1.73745311
167Anomalous pulmonary venous return (HP:0010772)1.73716928
168Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.73677238
169Abnormality of the renal collecting system (HP:0004742)1.72949950
170Wrist flexion contracture (HP:0001239)1.72335043
171Reduced subcutaneous adipose tissue (HP:0003758)1.71977572
172Nasolacrimal duct obstruction (HP:0000579)1.71858900
173Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71643588
174Amelogenesis imperfecta (HP:0000705)1.70580225
175Limited hip movement (HP:0008800)1.70287356
176Abnormality of renin-angiotensin system (HP:0000847)1.69622750
177Submucous cleft hard palate (HP:0000176)1.69559883
178Oligodactyly (hands) (HP:0001180)1.68650848
179Spondylolisthesis (HP:0003302)1.68520280
180Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.67441139
181Decreased circulating renin level (HP:0003351)1.67229053
182Vertebral compression fractures (HP:0002953)1.66002451
183Hypergonadotropic hypogonadism (HP:0000815)1.65757488
184Bell-shaped thorax (HP:0001591)1.64681632
185Pancreatic cysts (HP:0001737)1.64398380
186Hypoplastic scapulae (HP:0000882)1.64300819
187Aplasia/Hypoplasia of the scapulae (HP:0006713)1.64300819
188Mixed hearing impairment (HP:0000410)1.63906472
189Preaxial hand polydactyly (HP:0001177)1.63663573
190Congenital hepatic fibrosis (HP:0002612)1.62776104
191Chronic diarrhea (HP:0002028)1.62280235
192Optic nerve hypoplasia (HP:0000609)1.62237217
193Intestinal atresia (HP:0011100)1.60971090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.55793947
2SIK34.53806861
3TNIK3.26719522
4OBSCN3.20265770
5INSRR3.00171932
6TTN2.87112856
7CASK2.83550087
8PDGFRA2.48686394
9NEK92.46357100
10DDR22.31648237
11LATS12.30396620
12SIK22.28574469
13SIK12.28466040
14ZAK2.26806404
15MUSK2.25650151
16CDK82.09178308
17PAK21.87866498
18PTK21.80646405
19MARK31.80439250
20MET1.73273615
21BRSK21.73164635
22IRAK31.70511171
23TXK1.69408283
24AKT31.67104682
25MKNK21.63994209
26NEK61.61043983
27ADRBK21.57328849
28STK38L1.55141095
29PIK3CA1.53402059
30MST1R1.49952359
31NUAK11.49738558
32EIF2AK21.49561845
33SGK21.45879729
34CDK31.44501933
35TGFBR21.43426541
36MAPK131.42965425
37PDGFRB1.40223279
38GRK71.39914976
39SRPK11.38800093
40PAK31.37968365
41EPHA21.37781214
42RIPK11.36128694
43CAMK1D1.33118387
44CAMK1G1.29224565
45BMPR21.27513788
46LATS21.21666159
47BMPR1B1.21270798
48WNK11.21220270
49NTRK31.18047001
50TEC1.17655305
51CDK121.17597024
52ACVR1B1.15851415
53MAP3K141.15295461
54MELK1.13914883
55STK241.13058312
56STK391.11861084
57IRAK41.07455602
58LIMK11.05303617
59BRD41.04671459
60NLK1.02711417
61MAP3K71.01406164
62MAP3K61.00152633
63IRAK20.97293712
64IRAK10.97114326
65MAPK150.96467308
66FLT30.95877427
67RIPK40.95297153
68YES10.94311478
69MAP2K10.92942437
70MAP2K70.92512164
71PRKAA20.92429577
72PDK20.92170085
73TNK20.90635485
74GRK10.90312357
75FRK0.90121043
76CDC42BPA0.86194990
77SGK30.84804943
78SGK4940.83668466
79SGK2230.83668466
80STK30.83489876
81CAMK10.83482944
82ADRBK10.81806591
83PIK3CG0.81724973
84TRPM70.80629151
85PLK40.78803546
86MARK20.78396981
87NTRK10.76848252
88ERBB30.76460620
89MTOR0.76177069
90MAPK70.74365840
91PHKG10.74348066
92PHKG20.74348066
93PRKCE0.71054003
94EPHB20.71002817
95MKNK10.70952617
96ROCK10.70120946
97MAP3K130.69858883
98MAP3K120.68270762
99STK380.67392540
100MAPKAPK30.66900270
101GSK3A0.65446999
102TIE10.64951734
103PKN10.64906589
104MST40.64714985
105EIF2AK30.64184135
106SGK10.63926946
107PRPF4B0.62387716
108TGFBR10.62123263
109PLK20.61108638
110MAPKAPK50.60216538
111EPHB10.58062839
112IKBKB0.54776596
113CHEK20.54599738
114MAP3K30.53816124
115FGFR10.53455375
116CHUK0.52716360
117PRKD10.52327791
118DMPK0.52228090
119PTK2B0.51784361
120ABL20.50032586
121ITK0.48980016
122RPS6KA20.48146032
123CAMK40.48040271
124PRKG10.47983972
125CSNK1A1L0.46346593
126FGFR30.46067369
127EPHA30.45699970
128TAOK30.44829641
129NTRK20.44296372
130PNCK0.43381685
131HIPK20.40392695
132KIT0.39529101
133ABL10.38452045
134WNK30.38094824
135VRK10.37063237
136RPS6KA50.37061163
137JAK10.36737992
138CDK60.34674010
139IKBKE0.34218847
140PRKD20.33696438
141CSNK1D0.33660213
142PINK10.33634908
143MAP2K30.33497350
144CDK70.32633058
145ERBB40.32400375
146FER0.32204541
147PRKAA10.30873543
148JAK30.30075972
149MAPK120.29285881
150DYRK1A0.29232053
151LMTK20.29031503
152EEF2K0.28911324
153PKN20.28591410
154CAMK2G0.28341131
155PRKCH0.28018862
156IGF1R0.27898211
157LYN0.27795530
158INSR0.27482818
159CAMK2D0.27093939

Predicted pathways (KEGG)

RankGene SetZ-score
1Focal adhesion_Homo sapiens_hsa045102.88405881
2Protein digestion and absorption_Homo sapiens_hsa049742.16962966
3Proteoglycans in cancer_Homo sapiens_hsa052052.08037571
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.01864123
5Nicotine addiction_Homo sapiens_hsa050331.93551542
6Sphingolipid metabolism_Homo sapiens_hsa006001.89852884
7Amoebiasis_Homo sapiens_hsa051461.78731059
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75215730
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.68250881
10Mineral absorption_Homo sapiens_hsa049781.65762244
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.64309785
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.60863396
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57286259
14Sulfur metabolism_Homo sapiens_hsa009201.53251286
15Tight junction_Homo sapiens_hsa045301.52341596
16Vascular smooth muscle contraction_Homo sapiens_hsa042701.48214408
17Hippo signaling pathway_Homo sapiens_hsa043901.48157462
18Circadian rhythm_Homo sapiens_hsa047101.46028812
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40029358
20Fanconi anemia pathway_Homo sapiens_hsa034601.39977275
21Ovarian steroidogenesis_Homo sapiens_hsa049131.38431184
22PI3K-Akt signaling pathway_Homo sapiens_hsa041511.33753741
23Taste transduction_Homo sapiens_hsa047421.33429414
24Hematopoietic cell lineage_Homo sapiens_hsa046401.32832690
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27624097
26Basal transcription factors_Homo sapiens_hsa030221.27621124
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27311827
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24940979
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22759308
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.22610786
31Hedgehog signaling pathway_Homo sapiens_hsa043401.19979661
32Serotonergic synapse_Homo sapiens_hsa047261.16165476
33Rheumatoid arthritis_Homo sapiens_hsa053231.15518221
34Melanoma_Homo sapiens_hsa052181.10933752
35Calcium signaling pathway_Homo sapiens_hsa040201.10501154
36Insulin resistance_Homo sapiens_hsa049311.08935059
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07995097
38Morphine addiction_Homo sapiens_hsa050321.07757312
39Pathways in cancer_Homo sapiens_hsa052001.07348496
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05831293
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.05117622
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05024541
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05012552
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03060263
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01612012
46Osteoclast differentiation_Homo sapiens_hsa043801.00178764
47Glutamatergic synapse_Homo sapiens_hsa047240.99966066
48Vitamin digestion and absorption_Homo sapiens_hsa049770.99523769
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.97569199
50Insulin secretion_Homo sapiens_hsa049110.96952217
51Wnt signaling pathway_Homo sapiens_hsa043100.96469369
52Ether lipid metabolism_Homo sapiens_hsa005650.96308020
53Phototransduction_Homo sapiens_hsa047440.95519703
54Axon guidance_Homo sapiens_hsa043600.94935895
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94464194
56cAMP signaling pathway_Homo sapiens_hsa040240.93042569
57Ras signaling pathway_Homo sapiens_hsa040140.92160465
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.92160227
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.91311001
60Selenocompound metabolism_Homo sapiens_hsa004500.90533390
61p53 signaling pathway_Homo sapiens_hsa041150.90370213
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89467108
63Arachidonic acid metabolism_Homo sapiens_hsa005900.87657402
64Bladder cancer_Homo sapiens_hsa052190.86891419
65Dorso-ventral axis formation_Homo sapiens_hsa043200.86084194
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85715672
67Type II diabetes mellitus_Homo sapiens_hsa049300.85381281
68Prostate cancer_Homo sapiens_hsa052150.84408023
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82629144
70Basal cell carcinoma_Homo sapiens_hsa052170.82088418
71Platelet activation_Homo sapiens_hsa046110.81827340
72TNF signaling pathway_Homo sapiens_hsa046680.81654940
73Oxytocin signaling pathway_Homo sapiens_hsa049210.81425576
74Inositol phosphate metabolism_Homo sapiens_hsa005620.80788737
75Salivary secretion_Homo sapiens_hsa049700.80715090
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80705251
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.80324959
78Adherens junction_Homo sapiens_hsa045200.80119058
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78980443
80ECM-receptor interaction_Homo sapiens_hsa045120.78573868
81Melanogenesis_Homo sapiens_hsa049160.78279865
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.78228327
83Autoimmune thyroid disease_Homo sapiens_hsa053200.78163726
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78057287
85Primary immunodeficiency_Homo sapiens_hsa053400.77804853
86Homologous recombination_Homo sapiens_hsa034400.76419862
87Glucagon signaling pathway_Homo sapiens_hsa049220.75889193
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75357619
89Complement and coagulation cascades_Homo sapiens_hsa046100.74683842
90Renin secretion_Homo sapiens_hsa049240.74357593
91Circadian entrainment_Homo sapiens_hsa047130.74217962
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73269983
93Choline metabolism in cancer_Homo sapiens_hsa052310.73163840
94African trypanosomiasis_Homo sapiens_hsa051430.72836454
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72739188
96Chronic myeloid leukemia_Homo sapiens_hsa052200.71665026
97Measles_Homo sapiens_hsa051620.69402828
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68092368
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67832404
100Non-homologous end-joining_Homo sapiens_hsa034500.67600858
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67582818
102Glioma_Homo sapiens_hsa052140.67572801
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67235154
104Notch signaling pathway_Homo sapiens_hsa043300.66620784
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66507174
106TGF-beta signaling pathway_Homo sapiens_hsa043500.66152059
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65891370
108Malaria_Homo sapiens_hsa051440.65638592
109Graft-versus-host disease_Homo sapiens_hsa053320.65556119
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64718884
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.64105079
112Thyroid cancer_Homo sapiens_hsa052160.63726933
113ErbB signaling pathway_Homo sapiens_hsa040120.63289445
114Herpes simplex infection_Homo sapiens_hsa051680.62920030
115Cholinergic synapse_Homo sapiens_hsa047250.61774977
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61181131
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.60053481
118Prolactin signaling pathway_Homo sapiens_hsa049170.59916769
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58913199
120Rap1 signaling pathway_Homo sapiens_hsa040150.58517082
121FoxO signaling pathway_Homo sapiens_hsa040680.58412623
122Histidine metabolism_Homo sapiens_hsa003400.57653050
123MAPK signaling pathway_Homo sapiens_hsa040100.57360698
124GABAergic synapse_Homo sapiens_hsa047270.57138381
125Insulin signaling pathway_Homo sapiens_hsa049100.57133328
126AMPK signaling pathway_Homo sapiens_hsa041520.56044577
127MicroRNAs in cancer_Homo sapiens_hsa052060.55807612
128Cocaine addiction_Homo sapiens_hsa050300.55058935
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54893156
130Amphetamine addiction_Homo sapiens_hsa050310.54694732
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54543569
132Pancreatic secretion_Homo sapiens_hsa049720.54078647
133Lysine degradation_Homo sapiens_hsa003100.53757064
134Renal cell carcinoma_Homo sapiens_hsa052110.53693073
135Dilated cardiomyopathy_Homo sapiens_hsa054140.53287781
136Pancreatic cancer_Homo sapiens_hsa052120.53136452
137Small cell lung cancer_Homo sapiens_hsa052220.52823911
138GnRH signaling pathway_Homo sapiens_hsa049120.52717988
139mTOR signaling pathway_Homo sapiens_hsa041500.52684228
140ABC transporters_Homo sapiens_hsa020100.52326704
141Endometrial cancer_Homo sapiens_hsa052130.51461459
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50081274
143PPAR signaling pathway_Homo sapiens_hsa033200.48172116
144Hepatitis C_Homo sapiens_hsa051600.47391851
145Renin-angiotensin system_Homo sapiens_hsa046140.47348216
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47250658
147Gap junction_Homo sapiens_hsa045400.45834999
148Toxoplasmosis_Homo sapiens_hsa051450.43803996
149Gastric acid secretion_Homo sapiens_hsa049710.42060214
150Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40772290
151Endocytosis_Homo sapiens_hsa041440.39756339
152Propanoate metabolism_Homo sapiens_hsa006400.38100298
153Estrogen signaling pathway_Homo sapiens_hsa049150.37786260

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