USP54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.37271506
2central nervous system myelination (GO:0022010)9.37271506
3myelination (GO:0042552)5.44060682
4axon ensheathment (GO:0008366)5.41424047
5ensheathment of neurons (GO:0007272)5.41424047
6L-amino acid import (GO:0043092)5.16616705
7fatty acid elongation (GO:0030497)4.63633928
8long-chain fatty acid biosynthetic process (GO:0042759)4.35940585
9myelin maintenance (GO:0043217)4.13136452
10negative regulation of protein localization to cell surface (GO:2000009)4.08202312
11amino acid import (GO:0043090)3.89619723
12negative regulation of neurotransmitter transport (GO:0051589)3.86773142
13negative regulation of neurotransmitter secretion (GO:0046929)3.79196636
14establishment of mitochondrion localization (GO:0051654)3.70768627
15oligodendrocyte differentiation (GO:0048709)3.69532679
16myelination in peripheral nervous system (GO:0022011)3.67432304
17peripheral nervous system axon ensheathment (GO:0032292)3.67432304
18presynaptic membrane organization (GO:0097090)3.63282116
19neuronal action potential propagation (GO:0019227)3.60462553
20biotin metabolic process (GO:0006768)3.60097306
21adult walking behavior (GO:0007628)3.52662546
22eye photoreceptor cell differentiation (GO:0001754)3.52621767
23photoreceptor cell differentiation (GO:0046530)3.52621767
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.52128448
25apical protein localization (GO:0045176)3.48848236
26potassium ion import (GO:0010107)3.48507946
27iron ion import (GO:0097286)3.47420612
28membrane tubulation (GO:0097320)3.47046576
29astrocyte development (GO:0014002)3.46118519
30postsynaptic membrane organization (GO:0001941)3.43535149
31peptidyl-tyrosine autophosphorylation (GO:0038083)3.43452973
32cellular potassium ion homeostasis (GO:0030007)3.41703897
33synaptic vesicle maturation (GO:0016188)3.41541666
34asymmetric protein localization (GO:0008105)3.38986867
35gamma-aminobutyric acid transport (GO:0015812)3.37197902
36prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.35377361
37substrate-independent telencephalic tangential migration (GO:0021826)3.28394171
38substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.28394171
39glycine transport (GO:0015816)3.28104615
40neuron cell-cell adhesion (GO:0007158)3.22970964
41neuronal ion channel clustering (GO:0045161)3.21365693
42cerebellar granule cell differentiation (GO:0021707)3.20532068
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.18592738
44transmission of nerve impulse (GO:0019226)3.18061008
45protein localization to synapse (GO:0035418)3.16075277
46presynaptic membrane assembly (GO:0097105)3.13512912
47neurotransmitter uptake (GO:0001504)3.13235546
48glycerophospholipid catabolic process (GO:0046475)3.11858416
49regulation of collateral sprouting (GO:0048670)3.11234778
50import into cell (GO:0098657)3.11185241
51sodium ion export (GO:0071436)3.10393327
52regulation of short-term neuronal synaptic plasticity (GO:0048172)3.08832504
53cerebral cortex radially oriented cell migration (GO:0021799)3.06635752
54nerve growth factor signaling pathway (GO:0038180)3.04802858
55ionotropic glutamate receptor signaling pathway (GO:0035235)3.04493286
56potassium ion homeostasis (GO:0055075)3.03888823
57regulation of cell communication by electrical coupling (GO:0010649)3.03794686
58Golgi to endosome transport (GO:0006895)3.00616902
59response to methylmercury (GO:0051597)2.98369530
60positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.98060782
61neurotransmitter catabolic process (GO:0042135)2.93994090
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.93969419
63locomotory exploration behavior (GO:0035641)2.93308096
64positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.92820394
65cerebellar Purkinje cell layer development (GO:0021680)2.91977477
66negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.87928367
67creatine metabolic process (GO:0006600)2.86179970
68cellular sodium ion homeostasis (GO:0006883)2.84076446
69negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80991122
70regulation of voltage-gated calcium channel activity (GO:1901385)2.80105248
71regulation of synaptic vesicle exocytosis (GO:2000300)2.77225617
72dendritic spine morphogenesis (GO:0060997)2.76662138
73auditory behavior (GO:0031223)2.76452548
74regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.75563055
75carnitine shuttle (GO:0006853)2.75432536
76dendrite morphogenesis (GO:0048813)2.74789116
77positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.72958993
78glutamate receptor signaling pathway (GO:0007215)2.71988266
79C4-dicarboxylate transport (GO:0015740)2.71501895
80positive regulation of oligodendrocyte differentiation (GO:0048714)2.71339167
81synaptic transmission, glutamatergic (GO:0035249)2.68693599
82cell communication involved in cardiac conduction (GO:0086065)2.68325294
83neuron recognition (GO:0008038)2.68288190
84axonal fasciculation (GO:0007413)2.66257117
85sarcoplasmic reticulum calcium ion transport (GO:0070296)2.65655326
86synaptic vesicle exocytosis (GO:0016079)2.65522247
87insulin-like growth factor receptor signaling pathway (GO:0048009)2.65486458
88regulation of neuronal synaptic plasticity (GO:0048168)2.64122152
89limb bud formation (GO:0060174)2.63875070
90positive regulation of potassium ion transport (GO:0043268)2.62377259
91astrocyte differentiation (GO:0048708)2.62092265
92branching involved in prostate gland morphogenesis (GO:0060442)2.61780027
93lateral sprouting from an epithelium (GO:0060601)2.61185715
94protein palmitoylation (GO:0018345)2.59878696
95cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.59551038
96glutamate secretion (GO:0014047)2.59115578
97negative regulation of synaptic transmission, GABAergic (GO:0032229)2.58764746
98neuron-neuron synaptic transmission (GO:0007270)2.58617300
99regulation of autophagic vacuole assembly (GO:2000785)2.56823201
100acidic amino acid transport (GO:0015800)2.54695691
101negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54688784
102mechanosensory behavior (GO:0007638)2.54568639
103neuromuscular process controlling posture (GO:0050884)2.52928443
104gamma-aminobutyric acid signaling pathway (GO:0007214)2.52914651
105response to redox state (GO:0051775)2.52535674
106layer formation in cerebral cortex (GO:0021819)2.52346067
107regulation of long-term neuronal synaptic plasticity (GO:0048169)2.50056557
108regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.50031683
109long-term memory (GO:0007616)2.47696271
110carnitine transmembrane transport (GO:1902603)2.47672030
111negative regulation of axonogenesis (GO:0050771)2.47557459
112positive regulation of membrane potential (GO:0045838)2.47077787
113L-glutamate transport (GO:0015813)2.46857347
114adult locomotory behavior (GO:0008344)2.46623141
115G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.45812288
116auditory receptor cell differentiation (GO:0042491)2.45757494
117regulation of membrane repolarization (GO:0060306)2.45326271
118positive regulation of sodium ion transport (GO:0010765)2.45294489
119response to auditory stimulus (GO:0010996)2.45169602
120regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.43585423
121ventricular cardiac muscle cell action potential (GO:0086005)2.43255330
122vocalization behavior (GO:0071625)2.41793025
123magnesium ion transport (GO:0015693)2.41731319
124membrane hyperpolarization (GO:0060081)2.41333330
125cerebellar Purkinje cell differentiation (GO:0021702)2.41017305
126neuromuscular junction development (GO:0007528)2.39754858
127neuromuscular process controlling balance (GO:0050885)2.38534610
128cilium or flagellum-dependent cell motility (GO:0001539)2.37032122
129negative regulation of inclusion body assembly (GO:0090084)2.36968780
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.36597015
131relaxation of cardiac muscle (GO:0055119)2.35733174
132membrane depolarization during action potential (GO:0086010)2.33832146
133fatty acid transmembrane transport (GO:1902001)2.31533000
134neurotransmitter secretion (GO:0007269)2.30503146
135cell communication by electrical coupling (GO:0010644)2.30442849
136negative regulation of glycogen biosynthetic process (GO:0045719)2.30419426
137negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.30127700
138myoblast fusion (GO:0007520)2.29563725
139regulation of actin filament-based movement (GO:1903115)2.27751740
140amino-acid betaine transport (GO:0015838)2.26008418
141carnitine transport (GO:0015879)2.26008418
142myotube differentiation (GO:0014902)2.25313084
143regulation of dendritic spine morphogenesis (GO:0061001)2.25042442
144cardiac conduction (GO:0061337)2.24774256
145cardiac muscle cell action potential (GO:0086001)2.24581436
146embryonic retina morphogenesis in camera-type eye (GO:0060059)2.24159491
147neuromuscular synaptic transmission (GO:0007274)2.23112177
148regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.21494672
149regulation of sodium ion transmembrane transport (GO:1902305)2.21381684
150macroautophagy (GO:0016236)2.20606085
151positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.19941558
152regulation of relaxation of muscle (GO:1901077)2.19502519
153regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.19335932
154striated muscle contraction (GO:0006941)2.19307611
155dendritic spine organization (GO:0097061)2.19279237
156regulation of sodium ion transmembrane transporter activity (GO:2000649)2.18940217
157visual learning (GO:0008542)2.18700815
158regulation of skeletal muscle contraction (GO:0014819)2.17860652
159regulation of synaptic vesicle transport (GO:1902803)2.17343022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.55315825
2GBX2_23144817_ChIP-Seq_PC3_Human3.17216977
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51182908
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49346452
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37615556
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25131097
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25131097
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.24839105
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.24139526
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17376174
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16198607
12DROSHA_22980978_ChIP-Seq_HELA_Human2.12653531
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.11009515
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.07999610
15AR_21572438_ChIP-Seq_LNCaP_Human2.06817297
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05282759
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04565015
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00776769
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.96669342
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.94780520
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94391886
22* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.93192934
23RARB_27405468_Chip-Seq_BRAIN_Mouse1.89252582
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.88523465
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.88407640
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85669281
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.80231682
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73639142
29IGF1R_20145208_ChIP-Seq_DFB_Human1.69745623
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66033368
31* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.64064109
32VDR_22108803_ChIP-Seq_LS180_Human1.61713686
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60625223
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60568881
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60388834
36REST_21632747_ChIP-Seq_MESCs_Mouse1.58376977
37* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.53213471
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51222643
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49552879
40AR_21909140_ChIP-Seq_LNCAP_Human1.48806642
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.47770433
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44129313
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.40571923
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38985851
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38126308
46SMAD4_21799915_ChIP-Seq_A2780_Human1.37035760
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.36371371
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35844803
49STAT3_23295773_ChIP-Seq_U87_Human1.35248597
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34002584
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33231297
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32152252
53TAF15_26573619_Chip-Seq_HEK293_Human1.31908144
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29282121
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28275360
56AHR_22903824_ChIP-Seq_MCF-7_Human1.26614463
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26256461
58STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.26192102
59TP53_16413492_ChIP-PET_HCT116_Human1.24533662
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23901643
61TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23227797
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.21991651
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.21320363
64* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20131523
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20126432
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19499156
67P300_19829295_ChIP-Seq_ESCs_Human1.19109363
68TCF4_23295773_ChIP-Seq_U87_Human1.18904585
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.18134877
70ER_23166858_ChIP-Seq_MCF-7_Human1.17957862
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17744570
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16969408
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16949200
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16600618
75NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16158242
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16053845
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15869778
78* SOX2_21211035_ChIP-Seq_LN229_Gbm1.11640367
79RXR_22108803_ChIP-Seq_LS180_Human1.10806448
80LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10702958
81CHD1_26751641_Chip-Seq_LNCaP_Human1.10479006
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.10317192
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10252016
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09230808
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08414171
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.08364164
87* FOXA1_25552417_ChIP-Seq_VCAP_Human1.06823343
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06741229
89SMAD3_21741376_ChIP-Seq_HESCs_Human1.06324150
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06317434
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.06260893
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05775039
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04712491
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04480065
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04480065
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.03919201
97FOXA2_19822575_ChIP-Seq_HepG2_Human1.03674899
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.03448319
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02817184
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02405473
101CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02278730
102AR_19668381_ChIP-Seq_PC3_Human1.02074334
103TBL1_22424771_ChIP-Seq_293T_Human1.00707977
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00174321
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00143066
106NANOG_18555785_Chip-Seq_ESCs_Mouse0.99356499
107GATA1_26923725_Chip-Seq_HPCs_Mouse0.99049400
108RNF2_27304074_Chip-Seq_NSC_Mouse0.98916741
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98878826
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98682034
111* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98023448
112FUS_26573619_Chip-Seq_HEK293_Human0.97926306
113AR_25329375_ChIP-Seq_VCAP_Human0.97189808
114SALL1_21062744_ChIP-ChIP_HESCs_Human0.95363555
115* SMAD4_21741376_ChIP-Seq_HESCs_Human0.95226873
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94769524
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93551694
118YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93420468
119CMYC_18555785_Chip-Seq_ESCs_Mouse0.91778987
120NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91131725
121SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.91129032
122* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90867028
123RUNX2_22187159_ChIP-Seq_PCA_Human0.90606185
124TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90414220
125BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90068774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.82780486
2MP0004859_abnormal_synaptic_plasticity3.73345256
3MP0003880_abnormal_central_pattern3.52905026
4MP0003950_abnormal_plasma_membrane3.30637715
5MP0004270_analgesia3.30572823
6MP0004885_abnormal_endolymph3.23096626
7MP0004858_abnormal_nervous_system2.91210343
8MP0001486_abnormal_startle_reflex2.81063031
9MP0003690_abnormal_glial_cell2.76510548
10MP0009046_muscle_twitch2.61842443
11MP0005423_abnormal_somatic_nervous2.57952261
12MP0003635_abnormal_synaptic_transmissio2.56541227
13MP0002272_abnormal_nervous_system2.51240060
14MP0002064_seizures2.51035490
15MP0003123_paternal_imprinting2.33320401
16MP0000778_abnormal_nervous_system2.19134827
17MP0009745_abnormal_behavioral_response2.16790852
18MP0003329_amyloid_beta_deposits2.14646546
19MP0003136_yellow_coat_color2.08406473
20MP0003634_abnormal_glial_cell1.98820319
21MP0008569_lethality_at_weaning1.96399144
22MP0002063_abnormal_learning/memory/cond1.91506171
23MP0001485_abnormal_pinna_reflex1.88374267
24MP0001529_abnormal_vocalization1.88217009
25MP0003646_muscle_fatigue1.87188513
26MP0004742_abnormal_vestibular_system1.82099456
27MP0004142_abnormal_muscle_tone1.79387947
28MP0010234_abnormal_vibrissa_follicle1.78595602
29MP0002734_abnormal_mechanical_nocicepti1.77910674
30MP0002572_abnormal_emotion/affect_behav1.76265628
31MP0003632_abnormal_nervous_system1.73495476
32MP0005551_abnormal_eye_electrophysiolog1.73171326
33MP0010678_abnormal_skin_adnexa1.70967668
34MP0005171_absent_coat_pigmentation1.70805792
35MP0001984_abnormal_olfaction1.68528656
36MP0000955_abnormal_spinal_cord1.67116112
37MP0002009_preneoplasia1.66978033
38MP0000566_synostosis1.64296417
39MP0002229_neurodegeneration1.58032757
40MP0004043_abnormal_pH_regulation1.57076758
41MP0000383_abnormal_hair_follicle1.54721486
42MP0003631_nervous_system_phenotype1.53908999
43MP0003633_abnormal_nervous_system1.51563964
44MP0003879_abnormal_hair_cell1.51418656
45MP0002067_abnormal_sensory_capabilities1.50219505
46MP0002882_abnormal_neuron_morphology1.49195522
47MP0001299_abnormal_eye_distance/1.46606326
48MP0005409_darkened_coat_color1.45265947
49MP0005410_abnormal_fertilization1.42192569
50MP0005646_abnormal_pituitary_gland1.40102673
51MP0001440_abnormal_grooming_behavior1.39852087
52MP0002638_abnormal_pupillary_reflex1.36951143
53MP0005623_abnormal_meninges_morphology1.36149551
54MP0000462_abnormal_digestive_system1.35442444
55MP0001905_abnormal_dopamine_level1.34019696
56MP0001968_abnormal_touch/_nociception1.30965200
57MP0004924_abnormal_behavior1.30098577
58MP0005386_behavior/neurological_phenoty1.30098577
59MP0001177_atelectasis1.28573272
60MP0002066_abnormal_motor_capabilities/c1.26903951
61MP0001970_abnormal_pain_threshold1.26636858
62MP0004145_abnormal_muscle_electrophysio1.26597517
63MP0004130_abnormal_muscle_cell1.21142535
64MP0002822_catalepsy1.16171712
65MP0009780_abnormal_chondrocyte_physiolo1.15644671
66MP0001346_abnormal_lacrimal_gland1.14294537
67MP0003137_abnormal_impulse_conducting1.13647813
68MP0001963_abnormal_hearing_physiology1.12169888
69MP0002152_abnormal_brain_morphology1.11644118
70MP0002752_abnormal_somatic_nervous1.10434673
71MP0000751_myopathy1.07983640
72MP0000747_muscle_weakness1.07787045
73MP0004087_abnormal_muscle_fiber1.06696544
74MP0000579_abnormal_nail_morphology1.05298348
75MP0004084_abnormal_cardiac_muscle1.04336041
76MP0002733_abnormal_thermal_nociception1.03883164
77MP0001501_abnormal_sleep_pattern1.03226164
78MP0002557_abnormal_social/conspecific_i1.02691782
79MP0004811_abnormal_neuron_physiology1.00574375
80MP0002269_muscular_atrophy0.98870365
81MP0001502_abnormal_circadian_rhythm0.97877214
82MP0005187_abnormal_penis_morphology0.97595033
83MP0002876_abnormal_thyroid_physiology0.96083404
84MP0003937_abnormal_limbs/digits/tail_de0.95942025
85MP0005167_abnormal_blood-brain_barrier0.93303248
86MP0006072_abnormal_retinal_apoptosis0.93145698
87MP0000647_abnormal_sebaceous_gland0.93127786
88MP0005620_abnormal_muscle_contractility0.93010170
89MP0005253_abnormal_eye_physiology0.91548646
90MP0005195_abnormal_posterior_eye0.91329617
91MP0002184_abnormal_innervation0.90986294
92MP0004381_abnormal_hair_follicle0.90476840
93MP0002090_abnormal_vision0.90287727
94MP0002249_abnormal_larynx_morphology0.90134162
95MP0004036_abnormal_muscle_relaxation0.90105120
96MP0002909_abnormal_adrenal_gland0.90003969
97MP0000631_abnormal_neuroendocrine_gland0.89638188
98MP0002108_abnormal_muscle_morphology0.88288047
99MP0005670_abnormal_white_adipose0.87924581
100MP0004134_abnormal_chest_morphology0.87146978
101MP0006276_abnormal_autonomic_nervous0.86844297
102MP0002736_abnormal_nociception_after0.83496366
103MP0004147_increased_porphyrin_level0.82373355
104MP0000733_abnormal_muscle_development0.81191955
105MP0004215_abnormal_myocardial_fiber0.81056230
106MP0002735_abnormal_chemical_nociception0.80570333
107MP0003861_abnormal_nervous_system0.79930131
108MP0005647_abnormal_sex_gland0.79895965
109MP0000759_abnormal_skeletal_muscle0.79559216
110MP0005369_muscle_phenotype0.78820295
111MP0003787_abnormal_imprinting0.78645439
112MP0004085_abnormal_heartbeat0.78604277
113MP0002106_abnormal_muscle_physiology0.76862251
114MP0006138_congestive_heart_failure0.76423041
115MP0005666_abnormal_adipose_tissue0.74857579
116MP0003938_abnormal_ear_development0.74462484
117MP0000604_amyloidosis0.74001271
118MP0003121_genomic_imprinting0.73866614
119MP0002653_abnormal_ependyma_morphology0.71047224
120MP0000762_abnormal_tongue_morphology0.70973800
121MP0000026_abnormal_inner_ear0.70327402
122MP0000537_abnormal_urethra_morphology0.63969440
123MP0004233_abnormal_muscle_weight0.62964396
124MP0001661_extended_life_span0.62535303
125MP0000467_abnormal_esophagus_morphology0.62098449
126MP0005388_respiratory_system_phenotype0.61236395
127MP0002133_abnormal_respiratory_system0.61236395
128MP0001943_abnormal_respiration0.59788519
129MP0000749_muscle_degeneration0.59741698

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.30852477
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.85366502
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.85366502
4Calf muscle hypertrophy (HP:0008981)4.08104902
5Muscle hypertrophy of the lower extremities (HP:0008968)4.06461257
6Myokymia (HP:0002411)3.97823071
7Supranuclear gaze palsy (HP:0000605)3.96188412
8Peripheral hypomyelination (HP:0007182)3.90244238
9Cerebral inclusion bodies (HP:0100314)3.88025255
10Abnormality of the corticospinal tract (HP:0002492)3.78243205
11Exercise-induced myalgia (HP:0003738)3.72222671
12Muscle fiber inclusion bodies (HP:0100299)3.65838977
13Onion bulb formation (HP:0003383)3.61551896
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.53096857
15Intention tremor (HP:0002080)3.46028152
16Dysmetria (HP:0001310)3.44733161
17Exercise-induced muscle cramps (HP:0003710)3.43963306
18Focal motor seizures (HP:0011153)3.41938557
19Nemaline bodies (HP:0003798)3.38048322
20Spastic gait (HP:0002064)3.28207609
21Alacrima (HP:0000522)3.26615058
22Action tremor (HP:0002345)3.21238745
23Ankle clonus (HP:0011448)3.15766120
24Bundle branch block (HP:0011710)3.13401799
25Aplasia involving bones of the extremities (HP:0009825)3.11336714
26Aplasia involving bones of the upper limbs (HP:0009823)3.11336714
27Aplasia of the phalanges of the hand (HP:0009802)3.11336714
28Termporal pattern (HP:0011008)3.07451084
29Insidious onset (HP:0003587)3.07451084
30Abnormal auditory evoked potentials (HP:0006958)2.95444821
31Cerebral hypomyelination (HP:0006808)2.93882450
32Obstructive sleep apnea (HP:0002870)2.90287514
33Scanning speech (HP:0002168)2.88197183
34Megalencephaly (HP:0001355)2.85394177
35Clumsiness (HP:0002312)2.84156333
36Abnormality of the calf musculature (HP:0001430)2.83636453
37Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.80420040
38Lip pit (HP:0100267)2.79849365
39Dysmetric saccades (HP:0000641)2.75833545
40Dysdiadochokinesis (HP:0002075)2.70476104
41Hyperkalemia (HP:0002153)2.70133220
42Sensory axonal neuropathy (HP:0003390)2.69369466
43Slow saccadic eye movements (HP:0000514)2.65176980
44Parakeratosis (HP:0001036)2.63993620
45Progressive cerebellar ataxia (HP:0002073)2.62426818
46Focal seizures (HP:0007359)2.58913631
47Decreased lacrimation (HP:0000633)2.57411105
48Sparse lateral eyebrow (HP:0005338)2.56692205
49Morphological abnormality of the inner ear (HP:0011390)2.49497886
50Postural instability (HP:0002172)2.48773954
51Epileptic encephalopathy (HP:0200134)2.46955499
52Neonatal hypoglycemia (HP:0001998)2.44095607
53Abnormality of the middle phalanges of the toes (HP:0010183)2.34856962
54Absent septum pellucidum (HP:0001331)2.29800116
55Broad-based gait (HP:0002136)2.27002558
56Anteriorly placed anus (HP:0001545)2.26555035
57Urinary urgency (HP:0000012)2.23603292
58Hyperglycinuria (HP:0003108)2.22910870
59Premature skin wrinkling (HP:0100678)2.22655021
60Gonadotropin excess (HP:0000837)2.22577502
61Hyperventilation (HP:0002883)2.22312203
62Germ cell neoplasia (HP:0100728)2.21336984
63Type 1 muscle fiber predominance (HP:0003803)2.20863309
64Humeroradial synostosis (HP:0003041)2.19940094
65Synostosis involving the elbow (HP:0003938)2.19940094
66Lower limb muscle weakness (HP:0007340)2.19323660
67Abnormality of the phalanges of the 2nd finger (HP:0009541)2.19021457
68Retinal dysplasia (HP:0007973)2.17651575
69Myopathic facies (HP:0002058)2.16571581
70Gaze-evoked nystagmus (HP:0000640)2.15981158
71Segmental peripheral demyelination/remyelination (HP:0003481)2.14678210
72Thickened helices (HP:0000391)2.14491656
73Depressed nasal tip (HP:0000437)2.13968039
74Coronal craniosynostosis (HP:0004440)2.10802516
75Febrile seizures (HP:0002373)2.10600165
76Split foot (HP:0001839)2.09901539
77Truncal ataxia (HP:0002078)2.08903141
78Urinary bladder sphincter dysfunction (HP:0002839)2.08885216
79Increased circulating renin level (HP:0000848)2.08340198
80Syncope (HP:0001279)2.07710833
81Hemiparesis (HP:0001269)2.06596599
82EMG: myopathic abnormalities (HP:0003458)2.05935139
83Esophageal atresia (HP:0002032)2.04661204
84Fetal akinesia sequence (HP:0001989)2.02104012
85Abnormality of the axillary hair (HP:0100134)2.01026001
86Abnormality of secondary sexual hair (HP:0009888)2.01026001
87Sudden death (HP:0001699)2.00171308
88Abnormality of the salivary glands (HP:0010286)1.97360290
89EMG: neuropathic changes (HP:0003445)1.96007469
90CNS hypomyelination (HP:0003429)1.95537177
91Septo-optic dysplasia (HP:0100842)1.94677256
92Muscle fiber splitting (HP:0003555)1.94634494
93Overriding aorta (HP:0002623)1.92827829
94Metabolic alkalosis (HP:0200114)1.92656669
95Right ventricular cardiomyopathy (HP:0011663)1.91692372
96Clonus (HP:0002169)1.91003068
97Myoglobinuria (HP:0002913)1.90639241
98Spastic tetraparesis (HP:0001285)1.90283695
99Decreased motor nerve conduction velocity (HP:0003431)1.88342219
100Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.86153181
101Gowers sign (HP:0003391)1.84671545
102Abnormality of the septum pellucidum (HP:0007375)1.84345734
103Foot dorsiflexor weakness (HP:0009027)1.83981259
104Laryngomalacia (HP:0001601)1.83851181
105Generalized tonic-clonic seizures (HP:0002069)1.82089272
106Abnormality of saccadic eye movements (HP:0000570)1.81105245
107Hypoplasia of the iris (HP:0007676)1.81005639
108Overgrowth (HP:0001548)1.80884161
109Abnormality of the foot musculature (HP:0001436)1.80374769
110Abnormality of the ischium (HP:0003174)1.80309943
111Hyporeflexia of lower limbs (HP:0002600)1.79749460
112Neuronal loss in central nervous system (HP:0002529)1.79640828
113Akinesia (HP:0002304)1.79294580
114Difficulty running (HP:0009046)1.76940974
115Absence seizures (HP:0002121)1.76810488
116Neuroendocrine neoplasm (HP:0100634)1.76411563
117Macroorchidism (HP:0000053)1.76360372
118Atonic seizures (HP:0010819)1.75415541
119Absent/shortened dynein arms (HP:0200106)1.74867560
120Dynein arm defect of respiratory motile cilia (HP:0012255)1.74867560
121Dialeptic seizures (HP:0011146)1.74017042
122Bronchomalacia (HP:0002780)1.73368136
123Frequent falls (HP:0002359)1.72862981
124Abnormal ciliary motility (HP:0012262)1.71208477
125Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.71192868
126Heart block (HP:0012722)1.71005519
127Abnormality of binocular vision (HP:0011514)1.70755845
128Diplopia (HP:0000651)1.70755845
129Abnormality of the fingertips (HP:0001211)1.69468469
130Prolonged QT interval (HP:0001657)1.69449293
131Aqueductal stenosis (HP:0002410)1.68790320
132Choreoathetosis (HP:0001266)1.68757427
133Skin pits (HP:0100276)1.68576051
134Sleep apnea (HP:0010535)1.67914435
135Pheochromocytoma (HP:0002666)1.67746974
136Abnormality of cochlea (HP:0000375)1.66255066
137Generalized myoclonic seizures (HP:0002123)1.66208306
138Myotonia (HP:0002486)1.65645776
139Hammertoe (HP:0001765)1.65111346
140Bifid scrotum (HP:0000048)1.64941334
141Depression (HP:0000716)1.64698534
142Bowel incontinence (HP:0002607)1.64193901
143Centrally nucleated skeletal muscle fibers (HP:0003687)1.64036536
144Long nose (HP:0003189)1.63831833
145Genetic anticipation (HP:0003743)1.63632724
146Anxiety (HP:0000739)1.62999379
147Widely spaced teeth (HP:0000687)1.62082970
148Hypoplastic pelvis (HP:0008839)1.61142462
149Mixed hearing impairment (HP:0000410)1.59792368
150Cupped ear (HP:0000378)1.59664868
151Neoplasm of the heart (HP:0100544)1.59431750
152Impaired vibration sensation in the lower limbs (HP:0002166)1.58929503
153Abnormal respiratory epithelium morphology (HP:0012253)1.58826505
154Abnormal respiratory motile cilium morphology (HP:0005938)1.58826505
155Gait imbalance (HP:0002141)1.58631895
156Hypokalemic alkalosis (HP:0001949)1.57813690
157Morphological abnormality of the pyramidal tract (HP:0002062)1.57225637
158Drooling (HP:0002307)1.56954072
159Abnormality of serine family amino acid metabolism (HP:0010894)1.56743006
160Abnormality of glycine metabolism (HP:0010895)1.56743006
161Abnormal respiratory motile cilium physiology (HP:0012261)1.56098080
162Rigidity (HP:0002063)1.55993532
163Impaired social interactions (HP:0000735)1.55492379
164Abnormal social behavior (HP:0012433)1.55492379
165Abnormality of the astrocytes (HP:0100707)1.55154075
166Astrocytoma (HP:0009592)1.55154075
167Subaortic stenosis (HP:0001682)1.51445596
168Abnormality of the left ventricular outflow tract (HP:0011103)1.51445596
169Poor coordination (HP:0002370)1.50175462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.77395272
2AKT34.57589195
3OXSR13.62950725
4EPHA42.62326196
5WNK12.41660938
6EEF2K2.36852895
7PKN12.27744100
8EPHB12.27135790
9FGFR22.25885857
10PNCK2.25832283
11MAPKAPK52.22686957
12CDK191.98095909
13NEK61.97727597
14TNIK1.94129735
15SGK2231.92905450
16SGK4941.92905450
17PAK61.89551257
18UHMK11.84306418
19FRK1.72775748
20BCR1.72132807
21PHKG11.69990634
22PHKG21.69990634
23MET1.67798554
24WNK41.61440216
25NTRK11.57667624
26NTRK31.55952907
27NTRK21.55820234
28PRKD31.52109564
29EPHA21.51824306
30FER1.50114407
31PRPF4B1.49177586
32TYRO31.43026677
33ROCK21.39185946
34CAMK2B1.37498994
35MARK11.37091992
36MARK21.36580281
37CSNK1A1L1.29768067
38DMPK1.29186318
39STK38L1.28915907
40MUSK1.28253069
41CAMK2D1.23389454
42CASK1.16953145
43CLK11.16055930
44GRK11.12851525
45LIMK11.12495604
46PBK1.11208143
47CAMK1G1.11003543
48CSNK1G21.08221371
49CSNK1G31.07628702
50CDK51.07330465
51PAK31.02936759
52ICK1.02191727
53TRIB31.01858049
54MAP3K90.99415365
55PINK10.98615587
56CAMK2A0.96421206
57PRKD10.95017004
58CDK120.94512270
59MAPK150.94405793
60CSNK1G10.92160961
61LMTK20.91374902
62MINK10.91362467
63CAMK2G0.91362117
64PRKAA20.91002222
65PDPK10.89544693
66FGR0.88571426
67LATS20.88557626
68KSR20.87955531
69PRKAA10.86330230
70STK110.77828477
71MTOR0.76515710
72MAP3K40.75842426
73CDK150.75828497
74BMPR1B0.73534429
75PRKCH0.72692212
76BRSK20.72492469
77MAPKAPK30.71970616
78CDK140.71655643
79CDK180.70302594
80CDK11A0.65324230
81TSSK60.64231337
82PRKCE0.64203736
83MAPK100.61576937
84RIPK10.60617421
85TTN0.60037975
86SGK10.59418607
87MAP3K70.59327287
88CSNK1D0.58277298
89LATS10.57649359
90PDK10.57593667
91CAMKK10.56998452
92STK380.56099097
93CDC42BPA0.54587410
94SGK30.53337982
95PRKG10.53302566
96CAMK10.53005424
97PRKCQ0.51818111
98SGK20.51812057
99PIK3CA0.51390394
100DDR20.51350864
101FYN0.50516288
102MAPK130.50218217
103PDGFRB0.50007619
104DYRK1A0.48821116
105ERBB20.48606148
106ROCK10.46968415
107HIPK20.45930849
108PRKACB0.45843231
109RPS6KA30.43843406
110EPHA30.42558615
111MAPK120.42367563
112CSNK1A10.42295806
113BRD40.40683926
114CAMK1D0.40440799
115MST40.40152942
116TAF10.39170970
117OBSCN0.39158495
118CSNK1E0.38774132
119INSRR0.38318794
120MAP3K60.38109278
121MAP2K40.37570949
122CAMK40.37355284
123DAPK20.37310176
124PRKCZ0.37188672
125TNK20.36673240
126GSK3B0.36411830
127PRKD20.35836201
128RET0.35493719
129MAP3K20.34732551
130RPS6KB10.34465909
131PRKDC0.32722623
132SIK10.29697844
133AKT20.29237640
134MAPK140.28768834

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.36118796
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.87289527
3Histidine metabolism_Homo sapiens_hsa003402.51104324
4GABAergic synapse_Homo sapiens_hsa047272.41476183
5Glutamatergic synapse_Homo sapiens_hsa047242.29439584
6Fatty acid elongation_Homo sapiens_hsa000622.16114388
7Nicotine addiction_Homo sapiens_hsa050332.13542528
8Ether lipid metabolism_Homo sapiens_hsa005652.11941583
9Steroid biosynthesis_Homo sapiens_hsa001002.02107959
10Morphine addiction_Homo sapiens_hsa050322.00972772
11Circadian entrainment_Homo sapiens_hsa047131.99939911
12Arginine and proline metabolism_Homo sapiens_hsa003301.99009344
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.89329732
14Circadian rhythm_Homo sapiens_hsa047101.85138033
15Salivary secretion_Homo sapiens_hsa049701.73590039
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70290489
17Dorso-ventral axis formation_Homo sapiens_hsa043201.70024267
18Axon guidance_Homo sapiens_hsa043601.63346695
19Gastric acid secretion_Homo sapiens_hsa049711.62766984
20Vitamin B6 metabolism_Homo sapiens_hsa007501.58776287
21beta-Alanine metabolism_Homo sapiens_hsa004101.58048620
22Long-term depression_Homo sapiens_hsa047301.56402547
23Cocaine addiction_Homo sapiens_hsa050301.54200000
24Synaptic vesicle cycle_Homo sapiens_hsa047211.49245055
25Olfactory transduction_Homo sapiens_hsa047401.48804039
26Serotonergic synapse_Homo sapiens_hsa047261.44638177
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44474237
28Lysine degradation_Homo sapiens_hsa003101.36900411
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36768816
30Long-term potentiation_Homo sapiens_hsa047201.36663004
31Amphetamine addiction_Homo sapiens_hsa050311.36028004
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35160734
33Dopaminergic synapse_Homo sapiens_hsa047281.33960379
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32239776
35Insulin secretion_Homo sapiens_hsa049111.31945015
36Renin secretion_Homo sapiens_hsa049241.31902530
37Propanoate metabolism_Homo sapiens_hsa006401.31702566
38Arginine biosynthesis_Homo sapiens_hsa002201.31129031
39Cholinergic synapse_Homo sapiens_hsa047251.27450973
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26183474
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23587306
42Sphingolipid metabolism_Homo sapiens_hsa006001.20775842
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19485840
44cAMP signaling pathway_Homo sapiens_hsa040241.18213878
45Glucagon signaling pathway_Homo sapiens_hsa049221.16653892
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16258798
47Fatty acid metabolism_Homo sapiens_hsa012121.15736925
48Phenylalanine metabolism_Homo sapiens_hsa003601.15168675
49Taste transduction_Homo sapiens_hsa047421.12826537
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.11144251
51Tight junction_Homo sapiens_hsa045301.10131763
52Renal cell carcinoma_Homo sapiens_hsa052111.09991856
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09491788
54Phospholipase D signaling pathway_Homo sapiens_hsa040721.09385519
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08992048
56Fatty acid biosynthesis_Homo sapiens_hsa000611.08089460
57Vascular smooth muscle contraction_Homo sapiens_hsa042701.07914473
58Dilated cardiomyopathy_Homo sapiens_hsa054141.06700324
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06683557
60Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03860954
61Calcium signaling pathway_Homo sapiens_hsa040201.03662212
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01771662
63Phototransduction_Homo sapiens_hsa047441.00153648
64Oxytocin signaling pathway_Homo sapiens_hsa049210.99659333
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99573929
66Pancreatic secretion_Homo sapiens_hsa049720.99290985
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98734019
68AMPK signaling pathway_Homo sapiens_hsa041520.98041680
69Gap junction_Homo sapiens_hsa045400.97003904
70ABC transporters_Homo sapiens_hsa020100.96209455
71ErbB signaling pathway_Homo sapiens_hsa040120.94884801
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93809892
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93651954
74Vitamin digestion and absorption_Homo sapiens_hsa049770.93535759
75Linoleic acid metabolism_Homo sapiens_hsa005910.92295260
76Ras signaling pathway_Homo sapiens_hsa040140.92000336
77GnRH signaling pathway_Homo sapiens_hsa049120.90662349
78Cardiac muscle contraction_Homo sapiens_hsa042600.90047415
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.89514245
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.89398875
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88017042
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86917461
83Pyruvate metabolism_Homo sapiens_hsa006200.86807890
84Melanogenesis_Homo sapiens_hsa049160.86397576
85Hedgehog signaling pathway_Homo sapiens_hsa043400.86334436
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85474327
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85230504
88Ovarian steroidogenesis_Homo sapiens_hsa049130.84150080
89Mineral absorption_Homo sapiens_hsa049780.84008942
90Choline metabolism in cancer_Homo sapiens_hsa052310.83811010
91Insulin signaling pathway_Homo sapiens_hsa049100.83417333
92Tryptophan metabolism_Homo sapiens_hsa003800.83018625
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82126481
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80236705
95Endometrial cancer_Homo sapiens_hsa052130.79248313
96Fatty acid degradation_Homo sapiens_hsa000710.78048116
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77725912
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77705006
99MAPK signaling pathway_Homo sapiens_hsa040100.76508213
100Adherens junction_Homo sapiens_hsa045200.73481171
101Endocytosis_Homo sapiens_hsa041440.72606055
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71025604
103Rap1 signaling pathway_Homo sapiens_hsa040150.70086696
104Insulin resistance_Homo sapiens_hsa049310.69972973
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69266528
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66967641
107Inositol phosphate metabolism_Homo sapiens_hsa005620.66304831
108Wnt signaling pathway_Homo sapiens_hsa043100.65825897
109mTOR signaling pathway_Homo sapiens_hsa041500.64758178
110Basal cell carcinoma_Homo sapiens_hsa052170.63438764
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.61962609
112Sulfur metabolism_Homo sapiens_hsa009200.61801575
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61432871
114Estrogen signaling pathway_Homo sapiens_hsa049150.61223501
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61131741
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60101740
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58969945
118Butanoate metabolism_Homo sapiens_hsa006500.58697720
119Hippo signaling pathway_Homo sapiens_hsa043900.57105326
120Thyroid hormone synthesis_Homo sapiens_hsa049180.54360161
121Collecting duct acid secretion_Homo sapiens_hsa049660.53799580
122Oocyte meiosis_Homo sapiens_hsa041140.53371402
123Type II diabetes mellitus_Homo sapiens_hsa049300.52508751
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49859455
125Vibrio cholerae infection_Homo sapiens_hsa051100.49099014
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48727801
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47986901
128ECM-receptor interaction_Homo sapiens_hsa045120.46019310
129Alcoholism_Homo sapiens_hsa050340.41890077
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37757983
131Bile secretion_Homo sapiens_hsa049760.37613627
132Glioma_Homo sapiens_hsa052140.35603087

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