USP6NL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to redox state (GO:0051775)6.07213217
2mesenchymal cell differentiation involved in renal system development (GO:2001012)5.89749218
3mesenchymal cell differentiation involved in kidney development (GO:0072161)5.89749218
4presynaptic membrane assembly (GO:0097105)5.78189137
5DNA strand renaturation (GO:0000733)5.76972896
6axon ensheathment in central nervous system (GO:0032291)5.68521278
7central nervous system myelination (GO:0022010)5.68521278
8fatty acid elongation (GO:0030497)5.59128382
9mitotic sister chromatid cohesion (GO:0007064)5.25227569
10tryptophan catabolic process (GO:0006569)5.14462154
11indole-containing compound catabolic process (GO:0042436)5.14462154
12indolalkylamine catabolic process (GO:0046218)5.14462154
13ensheathment of neurons (GO:0007272)5.10334344
14axon ensheathment (GO:0008366)5.10334344
15kynurenine metabolic process (GO:0070189)5.04489548
16myelination (GO:0042552)4.93846358
17oligodendrocyte differentiation (GO:0048709)4.88046281
18tryptophan metabolic process (GO:0006568)4.85419192
19presynaptic membrane organization (GO:0097090)4.82591788
20negative regulation of neurotransmitter secretion (GO:0046929)4.71970297
21indolalkylamine metabolic process (GO:0006586)4.48830481
22L-amino acid import (GO:0043092)4.22220873
23regulation of hippo signaling (GO:0035330)4.00381079
24gamma-aminobutyric acid transport (GO:0015812)3.98664818
25myelination in peripheral nervous system (GO:0022011)3.98335593
26peripheral nervous system axon ensheathment (GO:0032292)3.98335593
27regulation of rhodopsin mediated signaling pathway (GO:0022400)3.91905406
28rRNA catabolic process (GO:0016075)3.86391851
29cytoplasmic mRNA processing body assembly (GO:0033962)3.79432621
30interkinetic nuclear migration (GO:0022027)3.79118293
31eye photoreceptor cell differentiation (GO:0001754)3.78921678
32photoreceptor cell differentiation (GO:0046530)3.78921678
33asymmetric protein localization (GO:0008105)3.78458472
34apical protein localization (GO:0045176)3.74416071
35rhodopsin mediated signaling pathway (GO:0016056)3.73223188
36meiotic chromosome segregation (GO:0045132)3.73219748
37myelin maintenance (GO:0043217)3.69120771
38histone H3-K9 methylation (GO:0051567)3.44289891
39mesenchymal cell differentiation (GO:0048762)3.43449695
40cell differentiation involved in kidney development (GO:0061005)3.40755129
41renal filtration (GO:0097205)3.36684750
42negative regulation of mast cell activation (GO:0033004)3.35230954
43regulation of establishment of cell polarity (GO:2000114)3.31694202
44glomerular filtration (GO:0003094)3.31175110
45positive regulation of developmental pigmentation (GO:0048087)3.26178224
46L-fucose catabolic process (GO:0042355)3.25241837
47fucose catabolic process (GO:0019317)3.25241837
48L-fucose metabolic process (GO:0042354)3.25241837
49RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.24729570
50monoubiquitinated protein deubiquitination (GO:0035520)3.22495645
51peptidyl-tyrosine autophosphorylation (GO:0038083)3.20968147
52membrane assembly (GO:0071709)3.17744548
53endothelial cell morphogenesis (GO:0001886)3.14503469
54behavioral response to nicotine (GO:0035095)3.13843022
55long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.13265722
56negative regulation of neurotransmitter transport (GO:0051589)3.11833402
57myotube differentiation (GO:0014902)3.11453623
58neural tube formation (GO:0001841)3.08545940
59regulation of gene silencing by RNA (GO:0060966)3.04855189
60regulation of posttranscriptional gene silencing (GO:0060147)3.04855189
61regulation of gene silencing by miRNA (GO:0060964)3.04855189
62negative regulation of translation, ncRNA-mediated (GO:0040033)3.04400027
63regulation of translation, ncRNA-mediated (GO:0045974)3.04400027
64negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.04400027
65Rap protein signal transduction (GO:0032486)3.04299377
66regulation of histone H3-K9 methylation (GO:0051570)3.04187069
67DNA double-strand break processing (GO:0000729)3.02124215
68protein K48-linked deubiquitination (GO:0071108)3.01979981
69microtubule anchoring (GO:0034453)2.99996867
70amine catabolic process (GO:0009310)2.97589375
71cellular biogenic amine catabolic process (GO:0042402)2.97589375
72nerve growth factor signaling pathway (GO:0038180)2.97500732
73amino acid import (GO:0043090)2.95604905
74midgut development (GO:0007494)2.94665160
75regulation of establishment or maintenance of cell polarity (GO:0032878)2.94442061
76establishment of mitochondrion localization (GO:0051654)2.93840301
77positive regulation of defense response to virus by host (GO:0002230)2.91417037
78DNA methylation involved in gamete generation (GO:0043046)2.91305544
79snRNA transcription (GO:0009301)2.89755699
80protein K11-linked deubiquitination (GO:0035871)2.89379055
81import into cell (GO:0098657)2.88928926
82reciprocal meiotic recombination (GO:0007131)2.88823534
83reciprocal DNA recombination (GO:0035825)2.88823534
84somatic diversification of immune receptors via somatic mutation (GO:0002566)2.88597296
85somatic hypermutation of immunoglobulin genes (GO:0016446)2.88597296
86regulation of DNA endoreduplication (GO:0032875)2.88348845
87long-chain fatty acid biosynthetic process (GO:0042759)2.87827051
88cellular response to ethanol (GO:0071361)2.85326069
89astrocyte development (GO:0014002)2.85323975
90gene silencing by RNA (GO:0031047)2.85246408
91dorsal/ventral axis specification (GO:0009950)2.84938255
92synapsis (GO:0007129)2.84067715
93cholesterol biosynthetic process (GO:0006695)2.82261511
94histone H3-K9 modification (GO:0061647)2.79540521
95protein localization to endosome (GO:0036010)2.78803039
96ncRNA catabolic process (GO:0034661)2.78702062
97cytoskeletal anchoring at plasma membrane (GO:0007016)2.78062621
98double-strand break repair via homologous recombination (GO:0000724)2.77397105
99recombinational repair (GO:0000725)2.75902695
100somatic diversification of immunoglobulins (GO:0016445)2.75002706
101positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.74349488
102positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.74349488
103positive regulation of mitotic sister chromatid separation (GO:1901970)2.74349488
104fatty-acyl-CoA biosynthetic process (GO:0046949)2.74311898
105protein K63-linked deubiquitination (GO:0070536)2.73903670
106dicarboxylic acid biosynthetic process (GO:0043650)2.72026546
107DNA alkylation (GO:0006305)2.71190692
108DNA methylation (GO:0006306)2.71190692
109regulation of RNA export from nucleus (GO:0046831)2.71154769
110indole-containing compound metabolic process (GO:0042430)2.70845120
111nitrogen cycle metabolic process (GO:0071941)2.70440456
112Leydig cell differentiation (GO:0033327)2.70213452
113positive regulation of cAMP-mediated signaling (GO:0043950)2.69718576
114negative regulation of DNA-dependent DNA replication (GO:2000104)2.69658032
115regulation of centriole replication (GO:0046599)2.69059206
116regulation of nuclear cell cycle DNA replication (GO:0033262)2.68894479
117aromatic amino acid family catabolic process (GO:0009074)2.66733411
118regulation of centrosome duplication (GO:0010824)2.66368166
119somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.65503123
120isotype switching (GO:0045190)2.65503123
121somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.65503123
122replication fork processing (GO:0031297)2.63022005
123protein localization to cell surface (GO:0034394)2.62057953
124embryonic retina morphogenesis in camera-type eye (GO:0060059)2.61190131
125somatic recombination of immunoglobulin gene segments (GO:0016447)2.59928681
126regulation of pigment cell differentiation (GO:0050932)2.59506500
127histone H3-K36 demethylation (GO:0070544)2.58511281
128protein prenylation (GO:0018342)2.58216572
129prenylation (GO:0097354)2.58216572
130phosphatidylinositol 3-kinase signaling (GO:0014065)2.56091307
131negative regulation of histone methylation (GO:0031061)2.54707760
132cellular response to exogenous dsRNA (GO:0071360)2.54104390
133detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.53065143
134DNA methylation or demethylation (GO:0044728)2.52262593
135urea metabolic process (GO:0019627)2.52215709
136urea cycle (GO:0000050)2.52215709
137nuclear pore complex assembly (GO:0051292)2.51633377
138negative regulation of systemic arterial blood pressure (GO:0003085)2.50961379
139detection of light stimulus involved in sensory perception (GO:0050962)2.50910046
140detection of light stimulus involved in visual perception (GO:0050908)2.50910046
141mesodermal cell differentiation (GO:0048333)2.50784595
142histone H3-K4 trimethylation (GO:0080182)2.50646594
143epithelial cell differentiation involved in kidney development (GO:0035850)2.49964664
144cell morphogenesis involved in neuron differentiation (GO:0048667)2.48568180
145camera-type eye morphogenesis (GO:0048593)2.47250868
146DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.47049499
147lipid translocation (GO:0034204)2.46860381
148phospholipid translocation (GO:0045332)2.46860381
149glial cell differentiation (GO:0010001)2.46582245
150regulation of mesoderm development (GO:2000380)2.46490526
151regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.45641445
152benzene-containing compound metabolic process (GO:0042537)2.44320597
153multicellular organism reproduction (GO:0032504)2.44211806
154prostate gland growth (GO:0060736)2.44062211
155establishment of protein localization to Golgi (GO:0072600)2.43856908
156positive regulation of organelle assembly (GO:1902117)2.43114077
157long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.42877763
158response to methylmercury (GO:0051597)2.42289912
159peptidyl-lysine methylation (GO:0018022)2.42034953
160cellular response to ATP (GO:0071318)2.40797562
161negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.39593229
162regulation of centrosome cycle (GO:0046605)2.39329826
163response to vitamin E (GO:0033197)2.39258932
164positive regulation by host of viral transcription (GO:0043923)2.39162897
165glycerophospholipid catabolic process (GO:0046475)2.37044408
166adhesion of symbiont to host cell (GO:0044650)2.36890046
167virion attachment to host cell (GO:0019062)2.36890046
168establishment of mitotic spindle orientation (GO:0000132)2.36856728
169regulation of alkaline phosphatase activity (GO:0010692)2.36365057
170positive regulation of Rho protein signal transduction (GO:0035025)2.36056941
171limb bud formation (GO:0060174)2.35911604
172positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.35904590
173regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.35835024
174positive regulation of hormone biosynthetic process (GO:0046886)2.35477408
175Golgi to endosome transport (GO:0006895)2.34432649
176regulation of telomere maintenance (GO:0032204)2.34254982
177epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.33552736
178erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.33537351
179L-phenylalanine catabolic process (GO:0006559)2.33537351
180adipose tissue development (GO:0060612)2.33332685
181negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.32255695
182protein targeting to plasma membrane (GO:0072661)2.30901283
183pre-miRNA processing (GO:0031054)2.28884483
184membrane protein ectodomain proteolysis (GO:0006509)2.28130753
185establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.27924896
186mitochondrion transport along microtubule (GO:0047497)2.27924896
187hippo signaling (GO:0035329)2.27810138
188positive regulation of action potential (GO:0045760)2.27766364
189response to lipoprotein particle (GO:0055094)2.25898560
190regulation of somitogenesis (GO:0014807)2.24714635
191membrane tubulation (GO:0097320)2.23744154
192sterol biosynthetic process (GO:0016126)2.23331872
193mammary gland alveolus development (GO:0060749)2.23242868
194cell migration in hindbrain (GO:0021535)2.22565317
195platelet-derived growth factor receptor signaling pathway (GO:0048008)2.22314825
196phototransduction, visible light (GO:0007603)2.21478461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.96232922
2ZNF274_21170338_ChIP-Seq_K562_Hela3.28566888
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.21793728
4IGF1R_20145208_ChIP-Seq_DFB_Human2.85609161
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.81171665
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.61066338
7VDR_22108803_ChIP-Seq_LS180_Human2.55046646
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51659981
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.44330129
10* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.43437562
11EWS_26573619_Chip-Seq_HEK293_Human2.39779789
12* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.30355873
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26670878
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25728591
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.24453448
16FUS_26573619_Chip-Seq_HEK293_Human2.23202061
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.19874841
18IRF1_19129219_ChIP-ChIP_H3396_Human2.16925515
19ER_23166858_ChIP-Seq_MCF-7_Human2.12018155
20ZNF263_19887448_ChIP-Seq_K562_Human2.03867544
21FOXO3_23340844_ChIP-Seq_DLD1_Human2.03835393
22P300_19829295_ChIP-Seq_ESCs_Human2.03689808
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.03237964
24AR_21572438_ChIP-Seq_LNCaP_Human2.01966201
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.97340112
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.91841673
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.90725233
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.88959789
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.85828221
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.79471410
31TP53_16413492_ChIP-PET_HCT116_Human1.78468264
32TAF15_26573619_Chip-Seq_HEK293_Human1.72785672
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72151295
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70424016
35* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69037489
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.68774577
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.65287392
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64820406
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62646137
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.62629183
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.61750902
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60593216
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59345391
44EZH2_22144423_ChIP-Seq_EOC_Human1.58594609
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.58386752
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58050830
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56674512
48CBP_20019798_ChIP-Seq_JUKART_Human1.56674512
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55962588
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55880728
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54262396
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.53766161
53STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.53122695
54SMAD4_21799915_ChIP-Seq_A2780_Human1.51343687
55AHR_22903824_ChIP-Seq_MCF-7_Human1.49606306
56GBX2_23144817_ChIP-Seq_PC3_Human1.48217825
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46396756
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44431593
59TP53_18474530_ChIP-ChIP_U2OS_Human1.43840523
60CTNNB1_20460455_ChIP-Seq_HCT116_Human1.43317539
61AR_25329375_ChIP-Seq_VCAP_Human1.41781724
62* LXR_22158963_ChIP-Seq_LIVER_Mouse1.39862607
63* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39372568
64RXR_22108803_ChIP-Seq_LS180_Human1.36673302
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35575413
66* CDX2_22108803_ChIP-Seq_LS180_Human1.34837240
67FOXA2_19822575_ChIP-Seq_HepG2_Human1.34822859
68BCAT_22108803_ChIP-Seq_LS180_Human1.34524128
69TCF4_18268006_ChIP-ChIP_LS174T_Human1.34456224
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.34119959
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33398437
72DROSHA_22980978_ChIP-Seq_HELA_Human1.32138664
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.32081719
74GATA1_22025678_ChIP-Seq_K562_Human1.31816147
75SCL_19346495_ChIP-Seq_HPC-7_Human1.29009590
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27287674
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27259282
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26181167
79RUNX2_22187159_ChIP-Seq_PCA_Human1.25438483
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24393778
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24143001
82STAT3_23295773_ChIP-Seq_U87_Human1.23492613
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22465342
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22286741
85* TCF4_22108803_ChIP-Seq_LS180_Human1.20275150
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20254708
87SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19774659
88PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.18700064
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.18571265
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18396866
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.18346423
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17689979
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.17534786
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17101313
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16888415
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16090516
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15978632
98SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15311012
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14765068
100FOXM1_23109430_ChIP-Seq_U2OS_Human1.12930499
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.12870004
102SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12756229
103TP53_22573176_ChIP-Seq_HFKS_Human1.12520469
104* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12478345
105* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12478345
106FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12116637
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.11953383
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10865294
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10816939
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10408347
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10079560
112EZH2_27294783_Chip-Seq_ESCs_Mouse1.09898907
113ESR1_21235772_ChIP-Seq_MCF-7_Human1.09104846
114SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08620478
115NFE2_27457419_Chip-Seq_LIVER_Mouse1.08336163
116ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08188480
117CDX2_20551321_ChIP-Seq_CACO-2_Human1.08181832
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07559575
119* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07063577
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06813043
121CJUN_26792858_Chip-Seq_BT549_Human1.06534131
122SMAD3_21741376_ChIP-Seq_HESCs_Human1.05976306
123MYC_18940864_ChIP-ChIP_HL60_Human1.05877770
124MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05759706
125FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05238402
126GATA2_21666600_ChIP-Seq_HMVEC_Human1.05031535
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04916948
128FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04727154
129ISL1_27105846_Chip-Seq_CPCs_Mouse1.04271624
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03638076
131MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03566615
132RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02425563
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02287047
134* E2F1_18555785_Chip-Seq_ESCs_Mouse1.02200828
135NANOG_19829295_ChIP-Seq_ESCs_Human1.01342116
136SOX2_19829295_ChIP-Seq_ESCs_Human1.01342116
137HOXB7_26014856_ChIP-Seq_BT474_Human1.00722193
138GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00197583
139RXR_22158963_ChIP-Seq_LIVER_Mouse1.00051122
140* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99982821
141SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99902169
142* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99690323
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99667832
144TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99004621
145IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98169257
146RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97679625
147SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97519480
148GATA3_21878914_ChIP-Seq_MCF-7_Human0.96974440
149NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96696640
150NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96696640
151SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95599632
152TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94977489
153SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94459026
154POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94297446
155* SMRT_27268052_Chip-Seq_Bcells_Human0.93922816
156JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93440138
157* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93384866
158FOXA1_25552417_ChIP-Seq_VCAP_Human0.93020549
159* NANOG_18555785_Chip-Seq_ESCs_Mouse0.92940615
160SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92056009
161SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92056009
162TP63_23658742_ChIP-Seq_EP156T_Human0.91858098
163VDR_24787735_ChIP-Seq_THP-1_Human0.91704260
164* TCF4_23295773_ChIP-Seq_U87_Human0.91507541
165TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91050680
166PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90726791
167SMAD4_21741376_ChIP-Seq_HESCs_Human0.89200299
168YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88933568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.79551415
2MP0008057_abnormal_DNA_replication4.40284632
3MP0005423_abnormal_somatic_nervous4.33507448
4MP0010678_abnormal_skin_adnexa4.22616455
5MP0001986_abnormal_taste_sensitivity4.22235107
6MP0000920_abnormal_myelination3.40433613
7MP0008877_abnormal_DNA_methylation3.32004740
8MP0003950_abnormal_plasma_membrane3.18308607
9MP0000383_abnormal_hair_follicle3.02070297
10MP0002009_preneoplasia3.01936207
11MP0003195_calcinosis2.76882346
12MP0000569_abnormal_digit_pigmentation2.69273614
13MP0003690_abnormal_glial_cell2.59973193
14MP0006292_abnormal_olfactory_placode2.46411312
15MP0002653_abnormal_ependyma_morphology2.37546740
16MP0002796_impaired_skin_barrier2.35382875
17MP0003787_abnormal_imprinting2.22461605
18MP0005551_abnormal_eye_electrophysiolog2.21127456
19MP0003252_abnormal_bile_duct2.20196038
20MP0005646_abnormal_pituitary_gland2.06819597
21MP0000579_abnormal_nail_morphology2.03774731
22MP0004272_abnormal_basement_membrane2.01672997
23MP0010094_abnormal_chromosome_stability1.96827407
24MP0005171_absent_coat_pigmentation1.91219456
25MP0005623_abnormal_meninges_morphology1.89772254
26MP0002098_abnormal_vibrissa_morphology1.88466152
27MP0004381_abnormal_hair_follicle1.81603662
28MP0000377_abnormal_hair_follicle1.74253651
29MP0004270_analgesia1.72138624
30MP0003634_abnormal_glial_cell1.71530403
31MP0005409_darkened_coat_color1.70990686
32MP0004885_abnormal_endolymph1.70558272
33MP0000647_abnormal_sebaceous_gland1.67334793
34MP0000467_abnormal_esophagus_morphology1.66226528
35MP0009697_abnormal_copulation1.62875768
36MP0009384_cardiac_valve_regurgitation1.62631302
37MP0003453_abnormal_keratinocyte_physiol1.62293416
38MP0005248_abnormal_Harderian_gland1.58693636
39MP0000778_abnormal_nervous_system1.54439958
40MP0004043_abnormal_pH_regulation1.54336181
41MP0003937_abnormal_limbs/digits/tail_de1.53289202
42MP0000462_abnormal_digestive_system1.47932397
43MP0003693_abnormal_embryo_hatching1.47521991
44MP0003119_abnormal_digestive_system1.47198492
45MP0003632_abnormal_nervous_system1.46618123
46MP0001661_extended_life_span1.44236323
47MP0003718_maternal_effect1.44188707
48MP0000537_abnormal_urethra_morphology1.43420720
49MP0005501_abnormal_skin_physiology1.43178657
50MP0001346_abnormal_lacrimal_gland1.39812349
51MP0003646_muscle_fatigue1.38660669
52MP0002102_abnormal_ear_morphology1.36333922
53MP0003890_abnormal_embryonic-extraembry1.35173910
54MP0003011_delayed_dark_adaptation1.34787744
55MP0002139_abnormal_hepatobiliary_system1.33592637
56MP0010352_gastrointestinal_tract_polyps1.32696175
57MP0000762_abnormal_tongue_morphology1.30627881
58MP0005253_abnormal_eye_physiology1.29644335
59MP0005167_abnormal_blood-brain_barrier1.26622154
60MP0002229_neurodegeneration1.24909504
61MP0005451_abnormal_body_composition1.24458089
62MP0000631_abnormal_neuroendocrine_gland1.23879457
63MP0008058_abnormal_DNA_repair1.22992861
64MP0005085_abnormal_gallbladder_physiolo1.21257142
65MP0005310_abnormal_salivary_gland1.20995476
66MP0005220_abnormal_exocrine_pancreas1.20928951
67MP0005647_abnormal_sex_gland1.20839278
68MP0002160_abnormal_reproductive_system1.19595301
69MP0006054_spinal_hemorrhage1.19215199
70MP0000427_abnormal_hair_cycle1.18791513
71MP0005645_abnormal_hypothalamus_physiol1.17477961
72MP0003943_abnormal_hepatobiliary_system1.14577526
73MP0003121_genomic_imprinting1.14130091
74MP0005408_hypopigmentation1.14005106
75MP0005195_abnormal_posterior_eye1.13584118
76MP0000566_synostosis1.10040560
77MP0001293_anophthalmia1.09871132
78MP0004147_increased_porphyrin_level1.09683264
79MP0005389_reproductive_system_phenotype1.09512653
80MP0005391_vision/eye_phenotype1.09296163
81MP0005275_abnormal_skin_tensile1.05833263
82MP0001800_abnormal_humoral_immune1.04363396
83MP0003111_abnormal_nucleus_morphology1.02561760
84MP0002092_abnormal_eye_morphology1.01860923
85MP0003868_abnormal_feces_composition1.01731717
86MP0000733_abnormal_muscle_development1.01393126
87MP0002254_reproductive_system_inflammat1.00901432
88MP0000465_gastrointestinal_hemorrhage0.99484835
89MP0001324_abnormal_eye_pigmentation0.99143218
90MP0006072_abnormal_retinal_apoptosis0.97900016
91MP0002138_abnormal_hepatobiliary_system0.97610906
92MP0004742_abnormal_vestibular_system0.96711552
93MP0005174_abnormal_tail_pigmentation0.96468527
94MP0001340_abnormal_eyelid_morphology0.95961600
95MP0005084_abnormal_gallbladder_morpholo0.95872493
96MP0003136_yellow_coat_color0.95613829
97MP0002697_abnormal_eye_size0.95403154
98MP0002166_altered_tumor_susceptibility0.95166663
99MP0003656_abnormal_erythrocyte_physiolo0.94462373
100MP0010771_integument_phenotype0.93004215
101MP0003300_gastrointestinal_ulcer0.92567706
102MP0004197_abnormal_fetal_growth/weight/0.92355154
103MP0010307_abnormal_tumor_latency0.92036967
104MP0008961_abnormal_basal_metabolism0.90390266
105MP0006276_abnormal_autonomic_nervous0.90238776
106MP0001216_abnormal_epidermal_layer0.89859639
107MP0002928_abnormal_bile_duct0.89520435
108MP0001919_abnormal_reproductive_system0.89095683
109MP0003045_fibrosis0.87402467
110MP0001929_abnormal_gametogenesis0.87239264
111MP0003935_abnormal_craniofacial_develop0.86931208
112MP0000372_irregular_coat_pigmentation0.86479357
113MP0000432_abnormal_head_morphology0.85928384
114MP0005360_urolithiasis0.85752449
115MP0001286_abnormal_eye_development0.85297182
116MP0000747_muscle_weakness0.84377815
117MP0003077_abnormal_cell_cycle0.84131524
118MP0005083_abnormal_biliary_tract0.82455574
119MP0008007_abnormal_cellular_replicative0.81489979
120MP0001835_abnormal_antigen_presentation0.81076343
121MP0003385_abnormal_body_wall0.80577123
122MP0002896_abnormal_bone_mineralization0.80259158
123MP0003091_abnormal_cell_migration0.80173648
124MP0002751_abnormal_autonomic_nervous0.79631823
125MP0002752_abnormal_somatic_nervous0.78384450
126MP0002060_abnormal_skin_morphology0.78080673
127MP0008995_early_reproductive_senescence0.77332355
128MP0002233_abnormal_nose_morphology0.76969419
129MP0000613_abnormal_salivary_gland0.75837193
130MP0005075_abnormal_melanosome_morpholog0.74946108
131MP0002095_abnormal_skin_pigmentation0.74790450
132MP0004185_abnormal_adipocyte_glucose0.73821227
133MP0004782_abnormal_surfactant_physiolog0.73183600
134MP0002090_abnormal_vision0.73169140
135MP0001145_abnormal_male_reproductive0.72504495
136MP0000653_abnormal_sex_gland0.72418271
137MP0002210_abnormal_sex_determination0.71685597
138MP0001697_abnormal_embryo_size0.71614089
139MP0003631_nervous_system_phenotype0.70941140
140MP0005410_abnormal_fertilization0.69734684
141MP0002084_abnormal_developmental_patter0.69466702
142MP0001879_abnormal_lymphatic_vessel0.69465981
143MP0004808_abnormal_hematopoietic_stem0.69303771
144MP0005365_abnormal_bile_salt0.69201875
145MP0010368_abnormal_lymphatic_system0.69097088
146MP0003861_abnormal_nervous_system0.69005135
147MP0002837_dystrophic_cardiac_calcinosis0.68940676
148MP0003698_abnormal_male_reproductive0.68155994
149MP0005187_abnormal_penis_morphology0.68047271
150MP0001486_abnormal_startle_reflex0.68040229
151MP0001119_abnormal_female_reproductive0.68025249
152MP0005379_endocrine/exocrine_gland_phen0.65939905
153MP0000689_abnormal_spleen_morphology0.65739685
154MP0001873_stomach_inflammation0.65132289
155MP0002882_abnormal_neuron_morphology0.65028268
156MP0001545_abnormal_hematopoietic_system0.65021277
157MP0005397_hematopoietic_system_phenotyp0.65021277
158MP0002452_abnormal_antigen_presenting0.65008004
159MP0002088_abnormal_embryonic_growth/wei0.64207489
160MP0008872_abnormal_physiological_respon0.64207058
161MP0001177_atelectasis0.63902606
162MP0001191_abnormal_skin_condition0.63246357
163MP0003755_abnormal_palate_morphology0.62323058
164MP0000955_abnormal_spinal_cord0.61560256
165MP0001529_abnormal_vocalization0.59772373
166MP0002938_white_spotting0.59365448
167MP0001984_abnormal_olfaction0.58829121
168MP0003705_abnormal_hypodermis_morpholog0.56686461
169MP0004264_abnormal_extraembryonic_tissu0.55531520
170MP0009703_decreased_birth_body0.55391778
171MP0001784_abnormal_fluid_regulation0.55018376
172MP0002109_abnormal_limb_morphology0.54992785
173MP0002081_perinatal_lethality0.54527503

Predicted human phenotypes

RankGene SetZ-score
1Fibular aplasia (HP:0002990)7.61617272
2Asymmetry of the thorax (HP:0001555)6.94361430
3Partial agenesis of the corpus callosum (HP:0001338)5.59375874
4Thoracic kyphosis (HP:0002942)5.55830050
5Thyroid-stimulating hormone excess (HP:0002925)4.88909788
6Focal segmental glomerulosclerosis (HP:0000097)4.85617783
7Aplasia involving bones of the extremities (HP:0009825)4.39476389
8Aplasia involving bones of the upper limbs (HP:0009823)4.39476389
9Aplasia of the phalanges of the hand (HP:0009802)4.39476389
10Hypoplasia of the capital femoral epiphysis (HP:0003090)4.33048695
11Insidious onset (HP:0003587)4.27801048
12Termporal pattern (HP:0011008)4.27801048
13Abnormality of the thoracic spine (HP:0100711)3.96899372
14Natal tooth (HP:0000695)3.92992799
15Glomerulosclerosis (HP:0000096)3.87773170
16Pancreatic cysts (HP:0001737)3.66134905
17Absent epiphyses (HP:0010577)3.59887952
18Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.59887952
19Aplasia/Hypoplasia of the fibula (HP:0006492)3.37507953
20Ulnar claw (HP:0001178)3.22428867
21Macroorchidism (HP:0000053)3.20052343
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.16540914
23Chromsome breakage (HP:0040012)3.13763834
24Abnormality of the lumbar spine (HP:0100712)2.99882160
25Sensory axonal neuropathy (HP:0003390)2.97547884
26Degeneration of the lateral corticospinal tracts (HP:0002314)2.96658315
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.96658315
28Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.96110287
29Segmental peripheral demyelination/remyelination (HP:0003481)2.95889347
30Broad ribs (HP:0000885)2.94402400
31True hermaphroditism (HP:0010459)2.91759878
32Peripheral hypomyelination (HP:0007182)2.90392830
33Fibular hypoplasia (HP:0003038)2.84611189
34Chronic hepatic failure (HP:0100626)2.83051284
35Pancreatic fibrosis (HP:0100732)2.76730561
36Abnormality of the renal cortex (HP:0011035)2.73808364
37Chin dimple (HP:0010751)2.72221559
38Delayed closure of the anterior fontanelle (HP:0001476)2.70696133
39Onion bulb formation (HP:0003383)2.70421821
40Chorioretinal atrophy (HP:0000533)2.69852754
41Advanced eruption of teeth (HP:0006288)2.68878489
42Nephronophthisis (HP:0000090)2.63567117
43Abnormality of the nasal septum (HP:0000419)2.61995208
44Parakeratosis (HP:0001036)2.61764654
45Pendular nystagmus (HP:0012043)2.58109995
46Ectopic kidney (HP:0000086)2.57883631
47Genetic anticipation (HP:0003743)2.54691352
48Tubular atrophy (HP:0000092)2.53832128
49Anal stenosis (HP:0002025)2.53279546
50Abnormality of the renal medulla (HP:0100957)2.51175931
51Duplication of thumb phalanx (HP:0009942)2.50866078
52Stomach cancer (HP:0012126)2.49714233
53Abnormality of the renal collecting system (HP:0004742)2.49586431
54Cutaneous finger syndactyly (HP:0010554)2.48468677
55Abnormality of the corticospinal tract (HP:0002492)2.47053474
56Clumsiness (HP:0002312)2.47041503
57Fair hair (HP:0002286)2.46989053
58Abnormality of the distal phalanx of the thumb (HP:0009617)2.46125992
59Tracheomalacia (HP:0002779)2.41284083
60Protruding tongue (HP:0010808)2.39631174
61Molar tooth sign on MRI (HP:0002419)2.38078430
62Abnormality of midbrain morphology (HP:0002418)2.38078430
63Attenuation of retinal blood vessels (HP:0007843)2.37662341
64Duplicated collecting system (HP:0000081)2.35239259
65Abnormality of chromosome stability (HP:0003220)2.34684021
66Intention tremor (HP:0002080)2.34401765
67Cerebellar dysplasia (HP:0007033)2.33460002
68Gaze-evoked nystagmus (HP:0000640)2.32206371
69Intrahepatic cholestasis (HP:0001406)2.31802973
70Abnormality of the phalanges of the hallux (HP:0010057)2.28591101
71Steppage gait (HP:0003376)2.27724942
72Abnormal auditory evoked potentials (HP:0006958)2.26162525
73Disproportionate tall stature (HP:0001519)2.25984169
74Septo-optic dysplasia (HP:0100842)2.25866523
75Hematochezia (HP:0002573)2.25302954
76Disproportionate short-trunk short stature (HP:0003521)2.23861780
77Abnormality of the ileum (HP:0001549)2.19239105
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.19185519
79Clubbing of toes (HP:0100760)2.18859357
80Dyschromatopsia (HP:0007641)2.17707366
81Type II lissencephaly (HP:0007260)2.16741266
82Aplasia/Hypoplasia of the tibia (HP:0005772)2.16712384
83Ankyloglossia (HP:0010296)2.16517830
84Hypoplasia of the iris (HP:0007676)2.15701259
85Abnormally folded helix (HP:0008544)2.14104707
86Overfolded helix (HP:0000396)2.12782673
87Keratoconus (HP:0000563)2.12665000
88Increased corneal curvature (HP:0100692)2.12665000
89Central scotoma (HP:0000603)2.09877226
90Abnormality of the fibula (HP:0002991)2.08527059
91Meckel diverticulum (HP:0002245)2.07586788
92Abnormality of DNA repair (HP:0003254)2.05717410
93Volvulus (HP:0002580)2.05591812
94Congenital stationary night blindness (HP:0007642)2.04319205
95Intestinal atresia (HP:0011100)2.03289988
96Short tibia (HP:0005736)2.03160141
97Furrowed tongue (HP:0000221)2.01782981
98Prostate neoplasm (HP:0100787)2.01437401
99Neoplasm of the adrenal cortex (HP:0100641)2.00655012
100Stridor (HP:0010307)1.99698920
101Absent hand (HP:0004050)1.99686813
102Sloping forehead (HP:0000340)1.99376227
103Abolished electroretinogram (ERG) (HP:0000550)1.99177294
104Nephroblastoma (Wilms tumor) (HP:0002667)1.96506004
105High pitched voice (HP:0001620)1.96430809
106Abnormal biliary tract physiology (HP:0012439)1.95409104
107Bile duct proliferation (HP:0001408)1.95409104
108Colon cancer (HP:0003003)1.94349852
109Enlarged kidneys (HP:0000105)1.92972706
110Neurofibrillary tangles (HP:0002185)1.92951624
111Aplasia/Hypoplasia of the patella (HP:0006498)1.92574536
112Cutaneous syndactyly (HP:0012725)1.92111328
113Cystic liver disease (HP:0006706)1.90425949
114Patellar aplasia (HP:0006443)1.89012930
115Vascular calcification (HP:0004934)1.88632014
116Nasal speech (HP:0001611)1.88066493
117Coarse hair (HP:0002208)1.87888452
118Curly hair (HP:0002212)1.87491660
119Abnormality of the prostate (HP:0008775)1.86364604
120Aplasia/Hypoplasia of the sternum (HP:0006714)1.84219076
121Abnormality of macular pigmentation (HP:0008002)1.84205652
122Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.84155872
123Short 1st metacarpal (HP:0010034)1.84155872
124Thickened calvaria (HP:0002684)1.83364926
125Abnormality of the proximal phalanges of the hand (HP:0009834)1.81266767
126Embryonal renal neoplasm (HP:0011794)1.81087532
127Deep venous thrombosis (HP:0002625)1.81078833
128Pigmentary retinal degeneration (HP:0001146)1.80853783
129Preaxial foot polydactyly (HP:0001841)1.80031329
130Alacrima (HP:0000522)1.80000563
131Progressive inability to walk (HP:0002505)1.79959073
132Increased CSF protein (HP:0002922)1.79944641
133Action tremor (HP:0002345)1.79848783
134Renal cortical cysts (HP:0000803)1.79725886
135Peripheral demyelination (HP:0011096)1.78907037
136Decreased lacrimation (HP:0000633)1.78787629
137Wrist flexion contracture (HP:0001239)1.78746247
1382-3 toe syndactyly (HP:0004691)1.78329697
139Bony spicule pigmentary retinopathy (HP:0007737)1.77928703
140Hypoplastic pelvis (HP:0008839)1.76945391
141Absent septum pellucidum (HP:0001331)1.76814293
142Abnormality of the carotid arteries (HP:0005344)1.75566373
143Bifid uvula (HP:0000193)1.75509352
144Biliary tract neoplasm (HP:0100574)1.75241424
145Cardiovascular calcification (HP:0011915)1.75116295
146Craniofacial hyperostosis (HP:0004493)1.75027539
147Small hand (HP:0200055)1.74323175
148Hyperventilation (HP:0002883)1.74261331
149Absent radius (HP:0003974)1.73381753
150Hammertoe (HP:0001765)1.71283673
151Dandy-Walker malformation (HP:0001305)1.70904739
152Progressive cerebellar ataxia (HP:0002073)1.70550171
153Decreased circulating renin level (HP:0003351)1.70102509
154Congenital hepatic fibrosis (HP:0002612)1.69589361
155Hypoplastic iliac wings (HP:0002866)1.69361581
156Hypoglycemic seizures (HP:0002173)1.68655962
157Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.67494305
158Generalized hypopigmentation of hair (HP:0011358)1.67487013
159Papillary thyroid carcinoma (HP:0002895)1.67343424
160Short thumb (HP:0009778)1.66275190
161Megalencephaly (HP:0001355)1.66254479
162Akinesia (HP:0002304)1.66117206
163Aplasia/Hypoplasia of the tongue (HP:0010295)1.66095837
164Short humerus (HP:0005792)1.66089812
165Tubulointerstitial nephritis (HP:0001970)1.65806665
166Decreased central vision (HP:0007663)1.65510173
167Carpal bone hypoplasia (HP:0001498)1.65226910
168Stenosis of the external auditory canal (HP:0000402)1.64636416
169Thyroiditis (HP:0100646)1.63726533
170Absent forearm bone (HP:0003953)1.62653578
171Aplasia involving forearm bones (HP:0009822)1.62653578
172Hypophosphatemic rickets (HP:0004912)1.62134789
173Concave nail (HP:0001598)1.61315887
174Exotropia (HP:0000577)1.59955959
175Postaxial foot polydactyly (HP:0001830)1.59881312
176Shallow orbits (HP:0000586)1.59484120
177Anencephaly (HP:0002323)1.59303209
178Lissencephaly (HP:0001339)1.58890829
179Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.58707633
180Abnormality of B cell number (HP:0010975)1.58689578
181IgA deficiency (HP:0002720)1.58196889
182Cone-rod dystrophy (HP:0000548)1.58111775
183Vitreoretinal degeneration (HP:0000655)1.58031014
184Abnormality of the pons (HP:0007361)1.57195520
185Hypoplastic labia majora (HP:0000059)1.56844018
186Acanthocytosis (HP:0001927)1.56741554
187Erythroderma (HP:0001019)1.56137481
188Abnormality of the 1st metacarpal (HP:0010009)1.55457868
189Long nose (HP:0003189)1.54762852
190Broad-based gait (HP:0002136)1.53376437
191Abnormality of male internal genitalia (HP:0000022)1.53034804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.50343152
2OXSR13.72433918
3CDK193.38396898
4DYRK1B3.02850957
5EPHB12.94330788
6FGFR22.83821198
7ZAK2.79177397
8ACVR1B2.77423960
9EPHA32.54399996
10ICK2.52849594
11ADRBK22.20308296
12MET2.17574552
13LATS12.11852052
14WNK12.10814369
15TLK12.06962823
16CCNB11.90295910
17MKNK21.90083247
18MST41.65673046
19CDC71.61963467
20EPHA21.59268375
21WNK41.59073911
22STK38L1.58059052
23BCR1.57359294
24TGFBR11.55037954
25SGK2231.54965317
26SGK4941.54965317
27NEK21.53653498
28CSNK1A1L1.53145907
29CAMK1G1.51246952
30MKNK11.49388787
31PKN11.48779251
32TAOK31.48500051
33NLK1.48480197
34FRK1.31483768
35TNIK1.29980448
36MAP3K141.28841524
37NEK61.28068985
38MAP3K41.26708444
39CDK121.23860279
40BRSK21.21240805
41DYRK1A1.21172256
42SGK21.17006567
43GRK11.16814089
44MAP3K101.15804439
45CSNK1G31.13357622
46CHUK1.11306378
47PAK31.10350145
48CAMK1D1.09651441
49CSNK1G11.09488535
50MAP4K21.09161724
51SGK31.08241164
52PNCK1.07720457
53TEC1.06997709
54NUAK11.05810686
55MAPK71.05699561
56TIE11.03330708
57PTK61.03304545
58EIF2AK31.03242506
59PRKCQ0.97955039
60IKBKB0.97073166
61ATR0.96139080
62PDGFRB0.95242500
63PLK40.93798742
64ERBB20.93749357
65WNK30.93064452
66CHEK20.91889586
67MST1R0.91522934
68CSNK1G20.91078114
69STK100.90931478
70EPHB20.89754005
71MARK20.89542562
72PAK60.88114620
73AKT30.86731756
74SIK10.86531963
75CSNK1D0.86388739
76SRPK10.84354827
77ATM0.82212461
78INSRR0.82120706
79MAPKAPK50.80192114
80FGR0.80108410
81ROCK20.79951402
82CASK0.79513383
83PBK0.78491362
84MAP3K20.76463369
85FER0.73125406
86TAF10.72630890
87DYRK30.71731306
88MAP2K20.70767492
89MELK0.70297679
90MAPK130.69099862
91FGFR10.68832714
92BTK0.68648084
93UHMK10.68537708
94CSF1R0.68414412
95PIM10.68212795
96STK30.67953276
97TYRO30.66107947
98MATK0.65725874
99TTK0.65539632
100PIK3CA0.65494326
101MTOR0.64291435
102SYK0.63514304
103TRPM70.63166524
104ERBB40.62722391
105PINK10.62569939
106MARK30.62031223
107MAP2K70.61412862
108GSK3A0.61370296
109MAP2K10.61217776
110PTK20.60979746
111KSR20.60628074
112DMPK0.60587096
113IRAK20.60103203
114PRPF4B0.59312035
115RPS6KA50.58633025
116HIPK20.58368326
117BRD40.56935016
118FGFR30.56508622
119CDK30.56360581
120PRKCH0.55352256
121BMPR1B0.54595567
122MAPK150.54544125
123LRRK20.54471660
124PRKAA20.54022386
125PLK10.53624472
126CDK40.53390432
127BMX0.53014767
128STK240.52917007
129CDK60.52032277
130PDPK10.52031407
131PRKD10.50944689
132TXK0.50866054
133IRAK10.50575338
134MAPK110.49660781
135RPS6KB20.48797087
136RET0.47595581
137AKT20.47551833
138INSR0.47276744
139ERBB30.46537911
140PAK20.45709675
141IKBKE0.45353921
142VRK10.44723877
143ADRBK10.44116759
144MAPK120.43933427
145RPS6KB10.43728364
146CDK90.42859851
147TRIM280.42587319
148SIK20.42221714
149PRKAA10.42198343
150FYN0.42034052
151STK40.41609298
152PRKCE0.41107665
153ALK0.40979298
154ABL10.40207115
155EGFR0.39735840
156PDK10.39220566
157EIF2AK20.39209568
158CSNK1A10.39117176
159PLK30.39110571
160CHEK10.38720932
161ITK0.38678353
162MAPK10.37941674
163MAP3K70.37349842

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.28084011
2Steroid biosynthesis_Homo sapiens_hsa001003.06610557
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.95580579
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.88027639
5Asthma_Homo sapiens_hsa053102.73809058
6Nitrogen metabolism_Homo sapiens_hsa009102.51027743
7Fatty acid elongation_Homo sapiens_hsa000622.47897705
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.46424521
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39169911
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.18625657
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.14178658
12Selenocompound metabolism_Homo sapiens_hsa004502.03427101
13Axon guidance_Homo sapiens_hsa043601.89474577
14Homologous recombination_Homo sapiens_hsa034401.80606680
15Basal transcription factors_Homo sapiens_hsa030221.79276573
16Fanconi anemia pathway_Homo sapiens_hsa034601.76096562
17Systemic lupus erythematosus_Homo sapiens_hsa053221.73623956
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.68605546
19Allograft rejection_Homo sapiens_hsa053301.66694644
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66062898
21Ether lipid metabolism_Homo sapiens_hsa005651.65387045
22Tight junction_Homo sapiens_hsa045301.62654717
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.57259161
24Butanoate metabolism_Homo sapiens_hsa006501.56292005
25Renal cell carcinoma_Homo sapiens_hsa052111.50770662
26Basal cell carcinoma_Homo sapiens_hsa052171.49256941
27Autoimmune thyroid disease_Homo sapiens_hsa053201.48519606
28ECM-receptor interaction_Homo sapiens_hsa045121.48361858
29Graft-versus-host disease_Homo sapiens_hsa053321.48359325
30Non-homologous end-joining_Homo sapiens_hsa034501.45237842
31Caffeine metabolism_Homo sapiens_hsa002321.43909283
32Dorso-ventral axis formation_Homo sapiens_hsa043201.37907194
33Hippo signaling pathway_Homo sapiens_hsa043901.35808641
34Histidine metabolism_Homo sapiens_hsa003401.34670610
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.28140194
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27578925
37One carbon pool by folate_Homo sapiens_hsa006701.26805022
38RNA degradation_Homo sapiens_hsa030181.24393006
39Type I diabetes mellitus_Homo sapiens_hsa049401.21613902
40Fatty acid biosynthesis_Homo sapiens_hsa000611.21121793
41Wnt signaling pathway_Homo sapiens_hsa043101.20027184
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.18714267
43Hedgehog signaling pathway_Homo sapiens_hsa043401.16470025
44Olfactory transduction_Homo sapiens_hsa047401.15806656
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12831819
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12240211
47Sulfur metabolism_Homo sapiens_hsa009201.11592528
48Proteoglycans in cancer_Homo sapiens_hsa052051.09531039
49Primary immunodeficiency_Homo sapiens_hsa053401.08374088
50Fatty acid metabolism_Homo sapiens_hsa012121.08261647
51Adherens junction_Homo sapiens_hsa045201.08128614
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05816080
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05049095
54Small cell lung cancer_Homo sapiens_hsa052221.04449885
55Prostate cancer_Homo sapiens_hsa052151.04171167
56Lysine degradation_Homo sapiens_hsa003101.02748504
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99843850
58Herpes simplex infection_Homo sapiens_hsa051680.99315389
59Retinol metabolism_Homo sapiens_hsa008300.98743703
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98704827
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98046138
62Taste transduction_Homo sapiens_hsa047420.97537905
63Focal adhesion_Homo sapiens_hsa045100.97462698
64Linoleic acid metabolism_Homo sapiens_hsa005910.97409261
65ErbB signaling pathway_Homo sapiens_hsa040120.96821483
66Sphingolipid metabolism_Homo sapiens_hsa006000.95598852
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94143010
68Complement and coagulation cascades_Homo sapiens_hsa046100.93110446
69Staphylococcus aureus infection_Homo sapiens_hsa051500.92180996
70B cell receptor signaling pathway_Homo sapiens_hsa046620.89926334
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88854468
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88144088
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.87227667
74p53 signaling pathway_Homo sapiens_hsa041150.83647303
75Endometrial cancer_Homo sapiens_hsa052130.83071025
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.82224428
77MicroRNAs in cancer_Homo sapiens_hsa052060.81495280
78ABC transporters_Homo sapiens_hsa020100.81110521
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80909426
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80859304
81Ras signaling pathway_Homo sapiens_hsa040140.80853024
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80481819
83Peroxisome_Homo sapiens_hsa041460.80223945
84Pancreatic cancer_Homo sapiens_hsa052120.78291784
85Bile secretion_Homo sapiens_hsa049760.77804034
86Bladder cancer_Homo sapiens_hsa052190.77760918
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.77372643
88Long-term depression_Homo sapiens_hsa047300.76987496
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76466393
90Chronic myeloid leukemia_Homo sapiens_hsa052200.76175239
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75686795
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74801241
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74588091
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74551324
95Arginine biosynthesis_Homo sapiens_hsa002200.74017663
96Glycerolipid metabolism_Homo sapiens_hsa005610.73177556
97TGF-beta signaling pathway_Homo sapiens_hsa043500.72208840
98Influenza A_Homo sapiens_hsa051640.72099128
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68996977
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68226643
101Endocytosis_Homo sapiens_hsa041440.68192353
102Inositol phosphate metabolism_Homo sapiens_hsa005620.67955350
103Cell cycle_Homo sapiens_hsa041100.67749467
104Vitamin digestion and absorption_Homo sapiens_hsa049770.67687751
105Melanogenesis_Homo sapiens_hsa049160.67383734
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67168824
107Amoebiasis_Homo sapiens_hsa051460.67025723
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64733957
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64155172
110Type II diabetes mellitus_Homo sapiens_hsa049300.63393717
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.63130296
112Serotonergic synapse_Homo sapiens_hsa047260.62875476
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62781642
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62508463
115Fat digestion and absorption_Homo sapiens_hsa049750.61100998
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60347967
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60015140
118MAPK signaling pathway_Homo sapiens_hsa040100.59881270
119Protein digestion and absorption_Homo sapiens_hsa049740.59593575
120Alcoholism_Homo sapiens_hsa050340.59544088
121Rap1 signaling pathway_Homo sapiens_hsa040150.58841031
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58223499
123Pathways in cancer_Homo sapiens_hsa052000.56973486
124Tyrosine metabolism_Homo sapiens_hsa003500.56422664
125N-Glycan biosynthesis_Homo sapiens_hsa005100.56066701
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55698242
127Circadian rhythm_Homo sapiens_hsa047100.55219846
128Tryptophan metabolism_Homo sapiens_hsa003800.54419421
129Toxoplasmosis_Homo sapiens_hsa051450.53778332
130RNA transport_Homo sapiens_hsa030130.52911163
131Antigen processing and presentation_Homo sapiens_hsa046120.52803319
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52609679
133Prolactin signaling pathway_Homo sapiens_hsa049170.52455206
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.52062984
135Leishmaniasis_Homo sapiens_hsa051400.52019223
136Chemical carcinogenesis_Homo sapiens_hsa052040.51531461
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51179660
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51143613
139Hematopoietic cell lineage_Homo sapiens_hsa046400.50646812
140TNF signaling pathway_Homo sapiens_hsa046680.50299773
141Platelet activation_Homo sapiens_hsa046110.49856417
142Ovarian steroidogenesis_Homo sapiens_hsa049130.48343812
143Choline metabolism in cancer_Homo sapiens_hsa052310.48316094
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.47363025
145PPAR signaling pathway_Homo sapiens_hsa033200.46674407
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45804945
147Arachidonic acid metabolism_Homo sapiens_hsa005900.44732931
148Gap junction_Homo sapiens_hsa045400.44049222
149Acute myeloid leukemia_Homo sapiens_hsa052210.43965783
150Hepatitis C_Homo sapiens_hsa051600.43718989
151Arginine and proline metabolism_Homo sapiens_hsa003300.43271454
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.43205333
153FoxO signaling pathway_Homo sapiens_hsa040680.43013806
154Melanoma_Homo sapiens_hsa052180.42457110
155T cell receptor signaling pathway_Homo sapiens_hsa046600.42452894
156mRNA surveillance pathway_Homo sapiens_hsa030150.39251543
157Viral carcinogenesis_Homo sapiens_hsa052030.39242286
158Rheumatoid arthritis_Homo sapiens_hsa053230.36580877
159Salivary secretion_Homo sapiens_hsa049700.35749999
160RNA polymerase_Homo sapiens_hsa030200.35390277
161Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34458386
162Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33519869
163African trypanosomiasis_Homo sapiens_hsa051430.32936531

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »