USP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.59474415
2nuclear pore organization (GO:0006999)6.37188474
3mitotic sister chromatid cohesion (GO:0007064)5.20281012
4pre-miRNA processing (GO:0031054)5.00143871
5negative regulation of histone methylation (GO:0031061)4.94019309
6pore complex assembly (GO:0046931)4.77825382
7regulation of histone H3-K9 methylation (GO:0051570)4.75450501
8protein localization to kinetochore (GO:0034501)4.65269350
9mitotic chromosome condensation (GO:0007076)4.48598679
10mitotic nuclear envelope disassembly (GO:0007077)4.41624850
11regulation of RNA export from nucleus (GO:0046831)4.31725997
12histone H3-K36 demethylation (GO:0070544)4.27166705
13nuclear envelope disassembly (GO:0051081)4.25023594
14membrane disassembly (GO:0030397)4.25023594
15regulation of histone H3-K27 methylation (GO:0061085)4.24329533
16DNA unwinding involved in DNA replication (GO:0006268)4.22130850
17sister chromatid segregation (GO:0000819)4.18570202
18positive regulation of chromosome segregation (GO:0051984)4.17174588
19positive regulation of mitotic sister chromatid separation (GO:1901970)4.16949719
20positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.16949719
21positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.16949719
22protein localization to chromosome, centromeric region (GO:0071459)4.16612544
23regulation of posttranscriptional gene silencing (GO:0060147)4.10233635
24regulation of gene silencing by miRNA (GO:0060964)4.10233635
25regulation of gene silencing by RNA (GO:0060966)4.10233635
26DNA replication-dependent nucleosome organization (GO:0034723)4.09734221
27DNA replication-dependent nucleosome assembly (GO:0006335)4.09734221
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.04926097
29mitotic sister chromatid segregation (GO:0000070)3.99975749
30heterochromatin organization (GO:0070828)3.98820294
31monoubiquitinated protein deubiquitination (GO:0035520)3.95602103
32DNA geometric change (GO:0032392)3.85200913
33DNA duplex unwinding (GO:0032508)3.84010051
34mitotic metaphase plate congression (GO:0007080)3.82993640
35regulation of sister chromatid cohesion (GO:0007063)3.82768282
36DNA topological change (GO:0006265)3.82172882
37chromatin assembly (GO:0031497)3.75537013
38histone H2A monoubiquitination (GO:0035518)3.75019596
39regulation of centriole replication (GO:0046599)3.72223863
40regulation of spindle organization (GO:0090224)3.69827655
41regulation of translational termination (GO:0006449)3.65244912
42negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.58097103
43dosage compensation (GO:0007549)3.55610989
44regulation of mitotic spindle organization (GO:0060236)3.54557164
45regulation of helicase activity (GO:0051095)3.54018946
46metaphase plate congression (GO:0051310)3.51976128
47regulation of nucleobase-containing compound transport (GO:0032239)3.48623882
48folic acid-containing compound biosynthetic process (GO:0009396)3.44649176
49histone lysine demethylation (GO:0070076)3.41903533
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.39372978
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.39372978
52negative regulation of histone modification (GO:0031057)3.38512885
53regulation of centrosome cycle (GO:0046605)3.38024213
54gene silencing by RNA (GO:0031047)3.36102037
55histone H2B ubiquitination (GO:0033523)3.35281934
56nuclear envelope organization (GO:0006998)3.33730858
57NLS-bearing protein import into nucleus (GO:0006607)3.30629338
58negative regulation of chromatin modification (GO:1903309)3.30088542
59regulation of chromosome segregation (GO:0051983)3.28723129
60DNA replication initiation (GO:0006270)3.27921503
61RNA stabilization (GO:0043489)3.27842513
62mRNA stabilization (GO:0048255)3.27842513
63regulation of histone methylation (GO:0031060)3.27426669
64protein localization to chromosome (GO:0034502)3.25857845
65peptidyl-lysine dimethylation (GO:0018027)3.24482593
66chromatin assembly or disassembly (GO:0006333)3.24302894
67histone demethylation (GO:0016577)3.23844322
68sister chromatid cohesion (GO:0007062)3.23839741
69chromosome condensation (GO:0030261)3.23515126
70negative regulation of DNA repair (GO:0045738)3.23182614
71DNA conformation change (GO:0071103)3.22743462
72regulation of translational fidelity (GO:0006450)3.19926270
73protein K6-linked ubiquitination (GO:0085020)3.19674122
74IMP biosynthetic process (GO:0006188)3.16707099
75spindle assembly involved in mitosis (GO:0090307)3.16641446
76negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.16519556
77negative regulation of mRNA metabolic process (GO:1903312)3.15426700
78regulation of NFAT protein import into nucleus (GO:0051532)3.14683948
79establishment of chromosome localization (GO:0051303)3.14280307
80negative regulation of mRNA processing (GO:0050686)3.13935052
81regulation of DNA endoreduplication (GO:0032875)3.13335504
82determination of adult lifespan (GO:0008340)3.11334191
83gene silencing (GO:0016458)3.11267031
84meiotic chromosome segregation (GO:0045132)3.08947232
85histone H3-K9 methylation (GO:0051567)3.04723651
86kinetochore organization (GO:0051383)3.03565103
87attachment of spindle microtubules to kinetochore (GO:0008608)3.03276835
88mRNA transport (GO:0051028)3.02870301
89microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.02596468
90protein export from nucleus (GO:0006611)3.02256660
91regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.01111121
92regulation of gene silencing (GO:0060968)3.00549958
93regulation of centrosome duplication (GO:0010824)2.98372561
94regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97217304
95regulation of telomere maintenance via telomerase (GO:0032210)2.96302129
96spliceosomal tri-snRNP complex assembly (GO:0000244)2.95800035
97DNA replication checkpoint (GO:0000076)2.95698169
98chromatin silencing (GO:0006342)2.95441890
99DNA packaging (GO:0006323)2.95382514
100histone H3-K9 demethylation (GO:0033169)2.93303279
101histone H3-K4 methylation (GO:0051568)2.92177424
102regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92073237
103chromosome segregation (GO:0007059)2.92003196
104cellular protein complex localization (GO:0034629)2.91558652
105nucleobase biosynthetic process (GO:0046112)2.90338026
106protein complex localization (GO:0031503)2.89637329
107synaptonemal complex assembly (GO:0007130)2.89614270
108stress granule assembly (GO:0034063)2.89221438
109spindle checkpoint (GO:0031577)2.88602561
110N-terminal protein amino acid acetylation (GO:0006474)2.88452711
111histone H4-K12 acetylation (GO:0043983)2.88151776
112cytoplasmic mRNA processing body assembly (GO:0033962)2.87529468
113regulation of mRNA stability (GO:0043488)2.87332683
114glucocorticoid receptor signaling pathway (GO:0042921)2.86430802
115regulation of mitotic sister chromatid separation (GO:0010965)2.85921187
116regulation of mitotic sister chromatid segregation (GO:0033047)2.85921187
117regulation of sister chromatid segregation (GO:0033045)2.85921187
118nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.85175621
119regulation of DNA damage checkpoint (GO:2000001)2.83688837
120DNA replication-independent nucleosome assembly (GO:0006336)2.83244576
121DNA replication-independent nucleosome organization (GO:0034724)2.83244576
1223-UTR-mediated mRNA stabilization (GO:0070935)2.80451852
123cellular response to epidermal growth factor stimulus (GO:0071364)2.78302844
124protein demethylation (GO:0006482)2.77127011
125protein dealkylation (GO:0008214)2.77127011
126nucleosome disassembly (GO:0006337)2.76017929
127protein-DNA complex disassembly (GO:0032986)2.76017929
128response to epidermal growth factor (GO:0070849)2.75196571
129regulation of histone H3-K4 methylation (GO:0051569)2.74022283
130embryonic process involved in female pregnancy (GO:0060136)2.72237114
131corticosteroid receptor signaling pathway (GO:0031958)2.69836211
132regulation of RNA stability (GO:0043487)2.69298887
133histone H3-K4 trimethylation (GO:0080182)2.67746506
134negative regulation of RNA splicing (GO:0033119)2.66304197
135V(D)J recombination (GO:0033151)2.61284872
136negative regulation of fibroblast apoptotic process (GO:2000270)2.60249002
137regulation of retinoic acid receptor signaling pathway (GO:0048385)2.59249881
138peptidyl-threonine phosphorylation (GO:0018107)2.59074324
139regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.58305471
140nucleus organization (GO:0006997)2.56061711
141DNA synthesis involved in DNA repair (GO:0000731)2.55782240
142positive regulation of cell cycle checkpoint (GO:1901978)2.55760369
143positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.54812329
144trophectodermal cell differentiation (GO:0001829)2.53414900
145alternative mRNA splicing, via spliceosome (GO:0000380)2.51955866
146DNA strand elongation involved in DNA replication (GO:0006271)2.49644433
147peptidyl-threonine modification (GO:0018210)2.49008408

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.13243866
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.02968951
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.59808281
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.24203407
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.16340477
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.10660166
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.85415608
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.67634917
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58398686
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.47132817
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.46933333
12MYC_22102868_ChIP-Seq_BL_Human2.46668682
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.30997504
14AR_21909140_ChIP-Seq_LNCAP_Human2.30090592
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23609443
16E2F7_22180533_ChIP-Seq_HELA_Human10.9163758
17MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96524602
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92018938
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.90645938
20CLOCK_20551151_ChIP-Seq_293T_Human1.89602553
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.86447927
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.86447927
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.86447927
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82304563
25SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.80526922
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.78818961
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75399597
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69879631
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66671850
30ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.63216605
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62209880
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61623407
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56009642
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52639664
35CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48902817
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48350378
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47771795
38* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.47512143
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.47244511
40KDM5A_27292631_Chip-Seq_BREAST_Human1.46796866
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.44441737
42ZNF263_19887448_ChIP-Seq_K562_Human1.44015724
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43740704
44CIITA_25753668_ChIP-Seq_RAJI_Human1.43393383
45SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42472196
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41393047
47XRN2_22483619_ChIP-Seq_HELA_Human1.40819496
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38509783
49KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36270506
50NANOG_21062744_ChIP-ChIP_HESCs_Human1.36207455
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35492382
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34592033
53TCF3_18692474_ChIP-Seq_MESCs_Mouse1.33890933
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33838288
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33303161
56TCF3_18692474_ChIP-Seq_MEFs_Mouse1.30276262
57GATA1_22025678_ChIP-Seq_K562_Human1.29936010
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26322034
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.25777347
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24811533
61* TCF7_22412390_ChIP-Seq_EML_Mouse1.24027263
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23742849
63NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.22544825
64* MYB_26560356_Chip-Seq_TH1_Human1.21573754
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20829519
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20356345
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20154715
68NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19791442
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19502727
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18785826
71SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16145196
72MAF_26560356_Chip-Seq_TH1_Human1.14922233
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14696088
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14046782
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13489936
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13208604
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11870944
78* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11262086
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09982320
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09895339
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09826017
82PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09668074
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09041712
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06898157
85SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.06247250
86* FOXA2_19822575_ChIP-Seq_HepG2_Human1.05986001
87* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04937896
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.04560927
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03355456
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02802111
91KDM2B_26808549_Chip-Seq_DND41_Human1.02742653
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02258129
93CHD1_26751641_Chip-Seq_LNCaP_Human1.01830923
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01279752
95* MYB_26560356_Chip-Seq_TH2_Human1.00551585
96GATA6_25053715_ChIP-Seq_YYC3_Human1.00096702
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98659951
98ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98563015
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98424743
100VDR_23849224_ChIP-Seq_CD4+_Human0.98293193
101* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97834602
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97798729
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97663729
104KDM2B_26808549_Chip-Seq_JURKAT_Human0.97063185
105* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.95406181
106SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95368232
107TTF2_22483619_ChIP-Seq_HELA_Human0.95095106
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94823619
109SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93169092
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92556415
111PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92405099
112TFEB_21752829_ChIP-Seq_HELA_Human0.91431830
113FOXP3_21729870_ChIP-Seq_TREG_Human0.90018317
114FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.88744927
115POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88693041
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88563339
117CREB1_15753290_ChIP-ChIP_HEK293T_Human0.88197042
118TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.87876154
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87860831
120NANOG_18692474_ChIP-Seq_MESCs_Mouse0.87581972
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86315402
122NCOR1_26117541_ChIP-Seq_K562_Human0.86293306
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86241433
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.86238212
125VDR_21846776_ChIP-Seq_THP-1_Human0.85456948
126UTX_26944678_Chip-Seq_JUKART_Human0.83460721
127PU_27001747_Chip-Seq_BMDM_Mouse0.83207827
128EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81644414
129DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81212114
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80345512
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79761126
132EST1_17652178_ChIP-ChIP_JURKAT_Human0.78696127
133ELK1_19687146_ChIP-ChIP_HELA_Human0.78695323
134PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78038048
135ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77977483
136ATF3_27146783_Chip-Seq_COLON_Human0.76887779
137ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.76821486

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.14379107
2MP0003111_abnormal_nucleus_morphology4.06869524
3MP0003693_abnormal_embryo_hatching3.88572631
4MP0008057_abnormal_DNA_replication3.88542184
5MP0004957_abnormal_blastocyst_morpholog3.47466992
6MP0003077_abnormal_cell_cycle3.40530504
7MP0010352_gastrointestinal_tract_polyps3.35006109
8MP0008877_abnormal_DNA_methylation3.10431499
9MP0005076_abnormal_cell_differentiation2.97036007
10MP0010307_abnormal_tumor_latency2.93471832
11MP0003705_abnormal_hypodermis_morpholog2.69910299
12MP0001730_embryonic_growth_arrest2.64477653
13MP0003123_paternal_imprinting2.63434191
14MP0010234_abnormal_vibrissa_follicle2.56823786
15MP0000350_abnormal_cell_proliferation2.40714234
16MP0008058_abnormal_DNA_repair2.33586358
17MP0008007_abnormal_cellular_replicative2.15089930
18MP0001672_abnormal_embryogenesis/_devel2.14396942
19MP0005380_embryogenesis_phenotype2.14396942
20MP0002084_abnormal_developmental_patter2.13762826
21MP0004197_abnormal_fetal_growth/weight/2.02583251
22MP0002086_abnormal_extraembryonic_tissu1.97968897
23MP0003121_genomic_imprinting1.95690193
24MP0003984_embryonic_growth_retardation1.95073196
25MP0001697_abnormal_embryo_size1.94741048
26MP0002088_abnormal_embryonic_growth/wei1.93165534
27MP0003787_abnormal_imprinting1.90925058
28MP0002085_abnormal_embryonic_tissue1.87141283
29MP0005451_abnormal_body_composition1.85927193
30MP0005409_darkened_coat_color1.83718332
31MP0003890_abnormal_embryonic-extraembry1.82146298
32MP0002080_prenatal_lethality1.67561774
33MP0003656_abnormal_erythrocyte_physiolo1.62081328
34MP0008932_abnormal_embryonic_tissue1.52012484
35MP0004808_abnormal_hematopoietic_stem1.51293152
36MP0004264_abnormal_extraembryonic_tissu1.50678536
37MP0002877_abnormal_melanocyte_morpholog1.50428536
38MP0003786_premature_aging1.48383588
39MP0002396_abnormal_hematopoietic_system1.46462368
40MP0001929_abnormal_gametogenesis1.44939293
41MP0000569_abnormal_digit_pigmentation1.44761034
42MP0003453_abnormal_keratinocyte_physiol1.44142172
43MP0002210_abnormal_sex_determination1.40944381
44MP0001849_ear_inflammation1.37724456
45MP0003567_abnormal_fetal_cardiomyocyte1.36745001
46MP0003566_abnormal_cell_adhesion1.35145594
47MP0003119_abnormal_digestive_system1.33892930
48MP0008260_abnormal_autophagy1.32435663
49MP0002653_abnormal_ependyma_morphology1.31631524
50MP0009703_decreased_birth_body1.30240742
51MP0009278_abnormal_bone_marrow1.28034806
52MP0001145_abnormal_male_reproductive1.26507963
53MP0004185_abnormal_adipocyte_glucose1.25424547
54MP0009672_abnormal_birth_weight1.23040785
55MP0001293_anophthalmia1.22733717
56MP0000313_abnormal_cell_death1.18645011
57MP0000537_abnormal_urethra_morphology1.17736615
58MP0009053_abnormal_anal_canal1.17700224
59MP0002019_abnormal_tumor_incidence1.16273390
60MP0000653_abnormal_sex_gland1.11610552
61MP0003943_abnormal_hepatobiliary_system1.11267155
62MP0005666_abnormal_adipose_tissue1.08703229
63MP0001545_abnormal_hematopoietic_system1.08284600
64MP0005397_hematopoietic_system_phenotyp1.08284600
65MP0003303_peritoneal_inflammation1.07707809
66MP0004381_abnormal_hair_follicle1.06041317
67MP0005187_abnormal_penis_morphology1.05239326
68MP0010630_abnormal_cardiac_muscle1.02661396
69MP0003221_abnormal_cardiomyocyte_apopto1.01882438
70MP0003698_abnormal_male_reproductive1.00361053
71MP0002089_abnormal_postnatal_growth/wei1.00206853
72MP0000703_abnormal_thymus_morphology0.99780499
73MP0000490_abnormal_crypts_of0.98916103
74MP0005623_abnormal_meninges_morphology0.98256590
75MP0002092_abnormal_eye_morphology0.96994988
76MP0001915_intracranial_hemorrhage0.96021899
77MP0002925_abnormal_cardiovascular_devel0.93508985
78MP0001216_abnormal_epidermal_layer0.92437071
79MP0000733_abnormal_muscle_development0.92258481
80MP0005621_abnormal_cell_physiology0.91404521
81MP0010678_abnormal_skin_adnexa0.89749631
82MP0008770_decreased_survivor_rate0.89653705
83MP0000428_abnormal_craniofacial_morphol0.89321608
84MP0003937_abnormal_limbs/digits/tail_de0.88936258
85MP0000627_abnormal_mammary_gland0.88589065
86MP0009697_abnormal_copulation0.88535327
87MP0004947_skin_inflammation0.87500403
88MP0000377_abnormal_hair_follicle0.86722990
89MP0004233_abnormal_muscle_weight0.86144858
90MP0003861_abnormal_nervous_system0.85984836
91MP0005023_abnormal_wound_healing0.85818962
92MP0003868_abnormal_feces_composition0.84852452
93MP0003300_gastrointestinal_ulcer0.83410242
94MP0005384_cellular_phenotype0.83051358
95MP0001666_abnormal_nutrient_absorption0.82964805
96MP0002098_abnormal_vibrissa_morphology0.82719926
97MP0002722_abnormal_immune_system0.81816191
98MP0005410_abnormal_fertilization0.79887162
99MP0000432_abnormal_head_morphology0.79816854
100MP0002161_abnormal_fertility/fecundity0.79739616
101MP0003935_abnormal_craniofacial_develop0.79430408
102MP0009333_abnormal_splenocyte_physiolog0.78884477
103MP0002009_preneoplasia0.78161758
104MP0003115_abnormal_respiratory_system0.75918244
105MP0002697_abnormal_eye_size0.75592370
106MP0000566_synostosis0.73598726
107MP0005310_abnormal_salivary_gland0.71784470
108MP0000685_abnormal_immune_system0.71431984
109MP0009931_abnormal_skin_appearance0.70581803
110MP0001853_heart_inflammation0.70489163
111MP0003941_abnormal_skin_development0.69885494
112MP0000689_abnormal_spleen_morphology0.69294001
113MP0001784_abnormal_fluid_regulation0.68663195
114MP0003315_abnormal_perineum_morphology0.68189622
115MP0002796_impaired_skin_barrier0.67547932
116MP0002398_abnormal_bone_marrow0.67460903
117MP0005501_abnormal_skin_physiology0.67219603
118MP0003763_abnormal_thymus_physiology0.67063646
119MP0001286_abnormal_eye_development0.67027710
120MP0003718_maternal_effect0.66976049
121MP0002006_tumorigenesis0.65331639
122MP0008961_abnormal_basal_metabolism0.65205837
123MP0002060_abnormal_skin_morphology0.64816708
124MP0002166_altered_tumor_susceptibility0.64531225
125MP0001119_abnormal_female_reproductive0.64074930
126MP0000266_abnormal_heart_morphology0.63920023
127MP0002111_abnormal_tail_morphology0.63639646
128MP0003699_abnormal_female_reproductive0.63536997
129MP0002429_abnormal_blood_cell0.62736149
130MP0003091_abnormal_cell_migration0.62700041
131MP0003283_abnormal_digestive_organ0.62308151

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.70589047
2Abnormality of the astrocytes (HP:0100707)3.74323382
3Astrocytoma (HP:0009592)3.74323382
4Volvulus (HP:0002580)3.63794243
5Medulloblastoma (HP:0002885)3.44651957
6Nephroblastoma (Wilms tumor) (HP:0002667)3.35287446
7Abnormality of the labia minora (HP:0012880)3.31539409
8Neoplasm of the oral cavity (HP:0100649)3.30129738
9Asymmetry of the thorax (HP:0001555)3.08265085
10Embryonal renal neoplasm (HP:0011794)3.07043377
11Colon cancer (HP:0003003)3.06923366
12Rhabdomyosarcoma (HP:0002859)3.06393033
13Glioma (HP:0009733)3.06185001
14Biliary tract neoplasm (HP:0100574)3.03629694
15Agnosia (HP:0010524)2.84940123
16Abnormality of the lower motor neuron (HP:0002366)2.75741746
17Impulsivity (HP:0100710)2.71685475
18Heterotopia (HP:0002282)2.71050590
19Chromsome breakage (HP:0040012)2.70421013
20Basal cell carcinoma (HP:0002671)2.68893516
21Increased nuchal translucency (HP:0010880)2.65042182
22Neoplasm of striated muscle (HP:0009728)2.64750509
23Overlapping toe (HP:0001845)2.61916756
24Selective tooth agenesis (HP:0001592)2.59105497
25Ankyloglossia (HP:0010296)2.57274077
26Birth length less than 3rd percentile (HP:0003561)2.56993985
27Abnormality of the fingertips (HP:0001211)2.55057680
28Progressive external ophthalmoplegia (HP:0000590)2.54896844
29Flat acetabular roof (HP:0003180)2.53123211
30Gastrointestinal carcinoma (HP:0002672)2.52591129
31Malignant gastrointestinal tract tumors (HP:0006749)2.52591129
32Sandal gap (HP:0001852)2.52527210
33Leiomyosarcoma (HP:0100243)2.52221359
34Uterine leiomyosarcoma (HP:0002891)2.52221359
35Prominent nose (HP:0000448)2.46656693
36Deep venous thrombosis (HP:0002625)2.45442474
37Dysmetric saccades (HP:0000641)2.42930967
38Abnormality of chromosome stability (HP:0003220)2.39263813
39Deviation of the thumb (HP:0009603)2.39009248
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38000012
41Sparse lateral eyebrow (HP:0005338)2.37288731
42Proximal placement of thumb (HP:0009623)2.36416937
43Missing ribs (HP:0000921)2.34664143
44Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.31627157
45Short 4th metacarpal (HP:0010044)2.31627157
46Diastasis recti (HP:0001540)2.30868922
47Facial hemangioma (HP:0000329)2.30097996
48Cafe-au-lait spot (HP:0000957)2.24884225
49Bladder carcinoma (HP:0002862)2.22503822
50Bladder neoplasm (HP:0009725)2.22503822
51Ectopic kidney (HP:0000086)2.15756560
52Deep palmar crease (HP:0006191)2.14194140
53Long eyelashes (HP:0000527)2.12991309
54Truncal obesity (HP:0001956)2.12776894
55Embryonal neoplasm (HP:0002898)2.12691392
56Urethral obstruction (HP:0000796)2.09509931
57Neonatal hypoglycemia (HP:0001998)2.09320975
58Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.09016306
59Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.09012624
60High pitched voice (HP:0001620)2.08748911
61Insidious onset (HP:0003587)2.08099161
62Termporal pattern (HP:0011008)2.08099161
63Vertebral arch anomaly (HP:0008438)2.06525516
64Papillary thyroid carcinoma (HP:0002895)2.06227370
65Hepatoblastoma (HP:0002884)2.03968000
66Hyperacusis (HP:0010780)2.02911594
67Amaurosis fugax (HP:0100576)2.02711973
68Aplasia/Hypoplasia of the sternum (HP:0006714)2.01747314
69Patellar aplasia (HP:0006443)2.01659793
70Shawl scrotum (HP:0000049)2.01036139
71Abnormal foot bone ossification (HP:0010675)1.99790093
72Renal cell carcinoma (HP:0005584)1.98486628
73Abnormality of oral frenula (HP:0000190)1.96428386
74Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.93339826
75Short 1st metacarpal (HP:0010034)1.93339826
76Hypopigmentation of the fundus (HP:0007894)1.92694255
77Myelodysplasia (HP:0002863)1.92281460
78Pelvic girdle muscle weakness (HP:0003749)1.92267038
79Short humerus (HP:0005792)1.90907633
80Acanthocytosis (HP:0001927)1.88781820
81Viral hepatitis (HP:0006562)1.85842244
82Pseudobulbar signs (HP:0002200)1.85451323
83Broad palm (HP:0001169)1.84775940
84Uterine neoplasm (HP:0010784)1.84087415
85Abnormal biliary tract morphology (HP:0012440)1.83877616
86Absent radius (HP:0003974)1.83475792
87Supernumerary ribs (HP:0005815)1.83311865
88Aplasia/Hypoplasia of the patella (HP:0006498)1.82683660
89Skull defect (HP:0001362)1.82584883
90Abnormality of chromosome segregation (HP:0002916)1.82427477
91Metaphyseal cupping (HP:0003021)1.82365027
92Advanced eruption of teeth (HP:0006288)1.81481268
93Dislocated radial head (HP:0003083)1.81268846
94Limited elbow extension (HP:0001377)1.81114820
95Anal stenosis (HP:0002025)1.80880137
96Aplasia/hypoplasia of the humerus (HP:0006507)1.80131940
97Obsessive-compulsive behavior (HP:0000722)1.77599569
98Macroorchidism (HP:0000053)1.77443274
99Renovascular hypertension (HP:0100817)1.77390379
100Slow saccadic eye movements (HP:0000514)1.77005588
10111 pairs of ribs (HP:0000878)1.75749764
102Small epiphyses (HP:0010585)1.75548750
103Breast hypoplasia (HP:0003187)1.74658861
104Subaortic stenosis (HP:0001682)1.74407371
105Abnormality of the left ventricular outflow tract (HP:0011103)1.74407371
106Cutis marmorata (HP:0000965)1.74286731
107Neoplasm of the small intestine (HP:0100833)1.74114667
108Abnormality of the distal phalanx of the thumb (HP:0009617)1.73954891
109Adenoma sebaceum (HP:0009720)1.73950795
110Angiofibromas (HP:0010615)1.73950795
111Low anterior hairline (HP:0000294)1.73134753
112Ovarian neoplasm (HP:0100615)1.72999355
113Subacute progressive viral hepatitis (HP:0006572)1.71069719
114Aplasia/Hypoplasia of the uvula (HP:0010293)1.70907166
115Broad thumb (HP:0011304)1.70570500
116Meckel diverticulum (HP:0002245)1.70345685
117Transitional cell carcinoma of the bladder (HP:0006740)1.70143930
118Neoplasm of the pancreas (HP:0002894)1.69579540
119Hypoplastic labia majora (HP:0000059)1.69546579
120Cutaneous melanoma (HP:0012056)1.69522212
121Esophageal atresia (HP:0002032)1.69521216
122Absent forearm bone (HP:0003953)1.68777494
123Aplasia involving forearm bones (HP:0009822)1.68777494
124Germ cell neoplasia (HP:0100728)1.68466573
125Narrow palate (HP:0000189)1.68328514
126Short phalanx of the thumb (HP:0009660)1.68035671
127Intestinal polyp (HP:0005266)1.67627778
128Abnormality of the carotid arteries (HP:0005344)1.67078060
129Wide nose (HP:0000445)1.67047011
130Abnormality of the salivary glands (HP:0010286)1.66206133
131Lip pit (HP:0100267)1.65799078
132Deep philtrum (HP:0002002)1.65782467
133Intestinal polyposis (HP:0200008)1.64736698
134Acute myeloid leukemia (HP:0004808)1.64596569
135Syringomyelia (HP:0003396)1.64575967
136Spinal cord lesions (HP:0100561)1.64575967
137Relative macrocephaly (HP:0004482)1.64323995
138Amyotrophic lateral sclerosis (HP:0007354)1.64323994
139Spinal muscular atrophy (HP:0007269)1.63628232
140Small intestinal stenosis (HP:0012848)1.63605460
141Duodenal stenosis (HP:0100867)1.63605460
142Atresia of the external auditory canal (HP:0000413)1.63536288
143Abnormality of the 4th metacarpal (HP:0010012)1.63482004
144Hyperkalemia (HP:0002153)1.62124180
145Long palpebral fissure (HP:0000637)1.59920849
146Abnormality of the preputium (HP:0100587)1.59259683
147Thyroid carcinoma (HP:0002890)1.58915741
148Abnormality of cochlea (HP:0000375)1.57014502
149Curly hair (HP:0002212)1.56666297
150Abnormality of the radial head (HP:0003995)1.55931705
151Obstructive sleep apnea (HP:0002870)1.55728300
152Somatic mutation (HP:0001428)1.54602825
153Abnormality of the nasal septum (HP:0000419)1.54401176
154Poikilocytosis (HP:0004447)1.52869957
155Cubitus valgus (HP:0002967)1.52377929
156Acute lymphatic leukemia (HP:0006721)1.51676222
157Mask-like facies (HP:0000298)1.50310379
158Recurrent viral infections (HP:0004429)1.48930192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.58322519
2CDC74.29510655
3SMG13.07261955
4EEF2K3.02168967
5NEK22.84037890
6PRPF4B2.79688220
7WEE12.70609344
8PKN22.59328218
9TTK2.51982735
10LATS12.49344846
11FGFR42.36676036
12PNCK2.24096050
13NEK12.16868032
14RPS6KB21.95313527
15BRD41.88129537
16TSSK61.74811318
17MAP3K101.72341924
18ALK1.71691481
19STK31.64132531
20CHEK11.60452821
21SCYL21.57419490
22CDK41.55900705
23EPHA21.51994804
24ATR1.51621858
25CDK61.50074069
26STK101.49605982
27SRPK11.46251590
28PLK11.45703118
29CHEK21.44329209
30PASK1.40791154
31PDK41.38521507
32PDK31.38521507
33TRIB31.36873032
34PLK31.34603434
35MELK1.30546052
36MAP3K81.27259155
37AURKB1.27213502
38ATM1.26569404
39WNK11.23666153
40TAF11.23222893
41CDK71.20231615
42MTOR1.17222838
43MAP3K131.17009262
44MAP3K141.16948438
45CAMK1D1.12326796
46CDK21.11838792
47NLK1.11318456
48ACVR1B1.07542151
49LATS21.05521137
50BUB11.04316260
51ICK0.98037186
52TYRO30.97696604
53STK40.96314791
54PLK40.93828616
55SGK30.93221250
56RIPK10.92316164
57CAMK1G0.91405979
58YES10.89655073
59CDK90.89545879
60CSNK1D0.86514558
61BRSK20.84886173
62RIPK40.84375306
63MAP3K90.82939224
64CDK10.82400489
65TGFBR10.82017046
66SIK10.81255205
67EIF2AK30.80335347
68PDGFRA0.77934462
69TNIK0.77357025
70SGK20.75410448
71MKNK20.75213511
72DMPK0.75194345
73PIM10.74929844
74CLK10.74860617
75EIF2AK10.72021116
76NEK60.70981892
77TTN0.70376724
78PTK60.69759980
79PRKDC0.69711460
80IRAK20.69549290
81KSR20.68578904
82LRRK20.67672225
83CSNK1E0.67610374
84MKNK10.67473938
85PAK40.66001105
86STK38L0.65946839
87DYRK30.62997748
88FLT30.62909779
89PDGFRB0.62247631
90FGR0.61981551
91GRK60.61218560
92PDK20.61066245
93NEK90.60170389
94MAPK110.58830949
95KSR10.57780147
96BRSK10.57669726
97MAPK140.57449913
98FGFR10.57443029
99ERN10.57324684
100STK380.56936058
101FGFR20.56560320
102RPS6KA40.56428929
103MARK30.54150276
104PRKD30.54077108
105FGFR30.53790616
106RET0.52274848
107MAP4K10.50748693
108PAK20.49993519
109RPS6KB10.48971740
110GSK3B0.48773972
111AKT30.48589542
112IRAK30.48451524
113MAP3K10.48064498
114BMX0.47467834
115MAPK100.47083243
116FRK0.45071012
117TLK10.44599379
118AURKA0.43905001
119IRAK10.43851027
120CSNK2A20.43415935
121MAP3K20.42705055
122BRAF0.41662051
123CDC42BPA0.40683015
124TAOK10.39826938
125MAP3K60.39525694
126STK240.38324800
127PRKCI0.37353986
128EIF2AK20.37182711
129SIK20.37166413
130MAPK10.37028969
131AKT10.35218656

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17750527
2Mismatch repair_Homo sapiens_hsa034303.15252548
3RNA transport_Homo sapiens_hsa030133.14286517
4DNA replication_Homo sapiens_hsa030303.04076448
5Cell cycle_Homo sapiens_hsa041102.82016703
6mRNA surveillance pathway_Homo sapiens_hsa030152.55322767
7Spliceosome_Homo sapiens_hsa030402.50790981
8One carbon pool by folate_Homo sapiens_hsa006702.22887650
9Non-homologous end-joining_Homo sapiens_hsa034502.04405153
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94324735
11Fanconi anemia pathway_Homo sapiens_hsa034601.91444668
12Nucleotide excision repair_Homo sapiens_hsa034201.78632870
13Homologous recombination_Homo sapiens_hsa034401.74553774
14Oocyte meiosis_Homo sapiens_hsa041141.74279341
15Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.70895407
16Base excision repair_Homo sapiens_hsa034101.70408774
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.68447213
18RNA degradation_Homo sapiens_hsa030181.62721346
19mTOR signaling pathway_Homo sapiens_hsa041501.59578189
20Systemic lupus erythematosus_Homo sapiens_hsa053221.57996696
21MicroRNAs in cancer_Homo sapiens_hsa052061.50080226
22p53 signaling pathway_Homo sapiens_hsa041151.48594686
23* Viral carcinogenesis_Homo sapiens_hsa052031.36845713
24Lysine degradation_Homo sapiens_hsa003101.34069314
25Basal transcription factors_Homo sapiens_hsa030221.33109074
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.25907109
27Adherens junction_Homo sapiens_hsa045201.24653761
28Antigen processing and presentation_Homo sapiens_hsa046121.23221276
29Colorectal cancer_Homo sapiens_hsa052101.17666181
30Chronic myeloid leukemia_Homo sapiens_hsa052201.16723166
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14965518
32Dorso-ventral axis formation_Homo sapiens_hsa043201.13692394
33HTLV-I infection_Homo sapiens_hsa051661.11251680
34Selenocompound metabolism_Homo sapiens_hsa004501.10829078
35Small cell lung cancer_Homo sapiens_hsa052221.10115076
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07915830
37Hippo signaling pathway_Homo sapiens_hsa043901.05253461
38RNA polymerase_Homo sapiens_hsa030201.04848563
39Non-small cell lung cancer_Homo sapiens_hsa052231.04159701
40Endometrial cancer_Homo sapiens_hsa052131.02163129
41Measles_Homo sapiens_hsa051621.01480087
42Thyroid cancer_Homo sapiens_hsa052160.97421605
43Central carbon metabolism in cancer_Homo sapiens_hsa052300.97361003
44TGF-beta signaling pathway_Homo sapiens_hsa043500.93676202
45* Epstein-Barr virus infection_Homo sapiens_hsa051690.90189631
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89703496
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.85992176
48Alcoholism_Homo sapiens_hsa050340.85921761
49Prostate cancer_Homo sapiens_hsa052150.84195678
50Notch signaling pathway_Homo sapiens_hsa043300.80795058
51Proteoglycans in cancer_Homo sapiens_hsa052050.79579671
52* Herpes simplex infection_Homo sapiens_hsa051680.79474651
53Glioma_Homo sapiens_hsa052140.79141266
54Basal cell carcinoma_Homo sapiens_hsa052170.78652613
55Estrogen signaling pathway_Homo sapiens_hsa049150.75986639
56Hepatitis C_Homo sapiens_hsa051600.74493524
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74469302
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73372255
59Pancreatic cancer_Homo sapiens_hsa052120.72374050
60Inositol phosphate metabolism_Homo sapiens_hsa005620.69155002
61VEGF signaling pathway_Homo sapiens_hsa043700.69014877
62Tight junction_Homo sapiens_hsa045300.67617008
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67256772
64Pyrimidine metabolism_Homo sapiens_hsa002400.65408674
65* FoxO signaling pathway_Homo sapiens_hsa040680.64914052
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64826187
67HIF-1 signaling pathway_Homo sapiens_hsa040660.63762064
68Renal cell carcinoma_Homo sapiens_hsa052110.63051289
69T cell receptor signaling pathway_Homo sapiens_hsa046600.61886131
70B cell receptor signaling pathway_Homo sapiens_hsa046620.61122314
71GnRH signaling pathway_Homo sapiens_hsa049120.60981622
72Glucagon signaling pathway_Homo sapiens_hsa049220.60818997
73Wnt signaling pathway_Homo sapiens_hsa043100.60223696
74Biosynthesis of amino acids_Homo sapiens_hsa012300.59593036
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59540655
76Acute myeloid leukemia_Homo sapiens_hsa052210.58910286
77Pathways in cancer_Homo sapiens_hsa052000.58793723
78Bladder cancer_Homo sapiens_hsa052190.58417755
79Hepatitis B_Homo sapiens_hsa051610.57820498
80Long-term potentiation_Homo sapiens_hsa047200.57658355
81Type II diabetes mellitus_Homo sapiens_hsa049300.57616806
82Prion diseases_Homo sapiens_hsa050200.57030320
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56949224
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.56561012
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.56201820
86AMPK signaling pathway_Homo sapiens_hsa041520.55880059
87Toxoplasmosis_Homo sapiens_hsa051450.55249283
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.54648381
89TNF signaling pathway_Homo sapiens_hsa046680.53383533
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.53367935
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51016210
92Hedgehog signaling pathway_Homo sapiens_hsa043400.50879433
93Fatty acid biosynthesis_Homo sapiens_hsa000610.50432461
94Melanoma_Homo sapiens_hsa052180.49857625
95Thyroid hormone synthesis_Homo sapiens_hsa049180.48575517
96Focal adhesion_Homo sapiens_hsa045100.48204340
97Osteoclast differentiation_Homo sapiens_hsa043800.47920922
98Primary immunodeficiency_Homo sapiens_hsa053400.47144282
99Apoptosis_Homo sapiens_hsa042100.46056752
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.46053811
101Insulin resistance_Homo sapiens_hsa049310.45793350
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.45668938
103ErbB signaling pathway_Homo sapiens_hsa040120.45590031
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45336339
105Choline metabolism in cancer_Homo sapiens_hsa052310.45096160
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45060343
107Pentose phosphate pathway_Homo sapiens_hsa000300.44440867
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44367556
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44119828
110Viral myocarditis_Homo sapiens_hsa054160.43734156
111Prolactin signaling pathway_Homo sapiens_hsa049170.43682668
112Insulin signaling pathway_Homo sapiens_hsa049100.42203557
113Influenza A_Homo sapiens_hsa051640.41961515
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41212699
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40877506
116Vitamin B6 metabolism_Homo sapiens_hsa007500.39866643
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.39528604
118MAPK signaling pathway_Homo sapiens_hsa040100.39042260

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