USP8P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.66760029
2regulation of memory T cell differentiation (GO:0043380)8.18209242
3germinal center formation (GO:0002467)7.79600760
4growth hormone receptor signaling pathway (GO:0060396)7.31455014
5negative regulation of B cell apoptotic process (GO:0002903)6.98825317
6innate immune response in mucosa (GO:0002227)6.79659313
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.68578717
8cellular response to growth hormone stimulus (GO:0071378)6.47429747
9negative regulation of Rho protein signal transduction (GO:0035024)6.36840962
10negative regulation of B cell mediated immunity (GO:0002713)6.32123764
11negative regulation of immunoglobulin mediated immune response (GO:0002890)6.32123764
12positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)6.17403943
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.11065064
14negative regulation of T-helper cell differentiation (GO:0045623)6.06642835
15negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)6.06642835
16negative regulation of viral entry into host cell (GO:0046597)5.98294360
17phagocytosis, recognition (GO:0006910)5.97293471
18regulation of germinal center formation (GO:0002634)5.91907027
19regulation of hypersensitivity (GO:0002883)5.82268140
20mucosal immune response (GO:0002385)5.66438056
21regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.59232429
22regulation of viral entry into host cell (GO:0046596)5.39513026
23rRNA transcription (GO:0009303)5.37064821
24organ or tissue specific immune response (GO:0002251)5.18979981
25antibacterial humoral response (GO:0019731)5.18473005
26antigen processing and presentation of endogenous antigen (GO:0019883)5.13202647
27negative regulation of type 2 immune response (GO:0002829)4.97093516
28regulation of heat generation (GO:0031650)4.85825178
29regulation of T-helper 2 cell differentiation (GO:0045628)4.81993422
30response to acidic pH (GO:0010447)4.78746947
31somite development (GO:0061053)4.71503306
32antimicrobial humoral response (GO:0019730)4.64983277
33regulation of acute inflammatory response to antigenic stimulus (GO:0002864)4.64796572
34negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.64023919
35positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.56960382
36negative regulation of JAK-STAT cascade (GO:0046426)4.52355411
37regulation of B cell apoptotic process (GO:0002902)4.50649954
38negative regulation of alpha-beta T cell differentiation (GO:0046639)4.41420832
39cellular response to pH (GO:0071467)4.37494334
40negative regulation of defense response to virus (GO:0050687)4.25409069
41mRNA cleavage (GO:0006379)4.22738791
42cell wall macromolecule catabolic process (GO:0016998)4.22738753
43positive regulation of natural killer cell differentiation (GO:0032825)4.14073954
44positive regulation of antigen processing and presentation (GO:0002579)4.08084791
45negative regulation of DNA recombination (GO:0045910)4.04921333
46antigen processing and presentation via MHC class Ib (GO:0002475)4.02626706
47regulation of meiosis I (GO:0060631)3.98459807
48interleukin-6-mediated signaling pathway (GO:0070102)3.94367949
49histone H2A acetylation (GO:0043968)3.91172217
50detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.86823238
51urate metabolic process (GO:0046415)3.83873847
52polyamine biosynthetic process (GO:0006596)3.78103376
53regulation of hematopoietic progenitor cell differentiation (GO:1901532)3.77643159
54DNA damage induced protein phosphorylation (GO:0006975)3.77136774
55positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.73878003
56negative regulation of mast cell activation (GO:0033004)3.68734279
57signal peptide processing (GO:0006465)3.64177320
58cell wall macromolecule metabolic process (GO:0044036)3.63861090
59positive regulation of T-helper 1 type immune response (GO:0002827)3.63791487
60entrainment of circadian clock by photoperiod (GO:0043153)3.60725857
61regulation of viral release from host cell (GO:1902186)3.60167747
62response to growth hormone (GO:0060416)3.46815018
63positive regulation of protein homodimerization activity (GO:0090073)3.42196083
64regulation of antigen processing and presentation (GO:0002577)3.41288711
65negative regulation of viral transcription (GO:0032897)3.41076660
66erythrocyte development (GO:0048821)3.36796930
67regulation of T-helper cell differentiation (GO:0045622)3.36766084
68positive regulation of osteoclast differentiation (GO:0045672)3.35547019
69peptidyl-histidine modification (GO:0018202)3.35418484
70phosphate ion transmembrane transport (GO:0035435)3.28917579
71cellular biogenic amine biosynthetic process (GO:0042401)3.28037620
72mitochondrial DNA replication (GO:0006264)3.26431513
73transcription from RNA polymerase III promoter (GO:0006383)3.23586080
74DNA integration (GO:0015074)3.21224970
75intraciliary transport (GO:0042073)3.12980236
76amine biosynthetic process (GO:0009309)3.09207739
77sulfate transport (GO:0008272)3.09032252
78entrainment of circadian clock (GO:0009649)3.03768774
79phosphate ion transport (GO:0006817)3.03460917
80DNA unwinding involved in DNA replication (GO:0006268)3.00926895
81protein-chromophore linkage (GO:0018298)3.00765695
82positive regulation of T cell mediated immunity (GO:0002711)2.99364879
83poly(A)+ mRNA export from nucleus (GO:0016973)2.99327335
84sulfate transmembrane transport (GO:1902358)2.98895672
85histone H2A ubiquitination (GO:0033522)2.98402045
86regulation of natural killer cell differentiation (GO:0032823)2.96105350
87purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.94508939
88long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.94088223
89positive regulation of T cell mediated cytotoxicity (GO:0001916)2.94072911
90histone H2B ubiquitination (GO:0033523)2.93993980
91JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.91355231
92positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.85409189
93myeloid leukocyte mediated immunity (GO:0002444)2.84652416
94regulation of megakaryocyte differentiation (GO:0045652)2.83873860
95photoperiodism (GO:0009648)2.82543324
96negative regulation of circadian rhythm (GO:0042754)2.81410859
97sensory perception of taste (GO:0050909)2.79048765
98regulation of defense response to virus by host (GO:0050691)2.74260368
99nucleosome assembly (GO:0006334)2.73398078
100immunoglobulin mediated immune response (GO:0016064)2.73276791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.54474747
2EGR1_23403033_ChIP-Seq_LIVER_Mouse4.57106087
3ZNF274_21170338_ChIP-Seq_K562_Hela4.31099013
4CIITA_25753668_ChIP-Seq_RAJI_Human3.46252284
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.01645438
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.99519668
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.93943297
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.87552380
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.86503816
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73758866
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.49784345
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.44413203
13STAT3_1855785_ChIP-Seq_MESCs_Mouse2.23182522
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.22784124
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12787083
16FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse2.09118125
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.05665810
18TP53_22573176_ChIP-Seq_HFKS_Human1.88384292
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85688668
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80047384
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79833003
22IRF1_19129219_ChIP-ChIP_H3396_Human1.78829802
23PKCTHETA_26484144_Chip-Seq_BREAST_Human1.78593705
24TDRD3_21172665_ChIP-Seq_MCF-7_Human1.78229335
25ETS1_22383799_ChIP-Seq_G1ME_Mouse1.75830242
26VDR_22108803_ChIP-Seq_LS180_Human1.75459465
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73896308
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.73516108
29ELK1_19687146_ChIP-ChIP_HELA_Human1.69406638
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.65282485
31FUS_26573619_Chip-Seq_HEK293_Human1.65086639
32KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.64580348
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63473620
34VDR_23849224_ChIP-Seq_CD4+_Human1.63461871
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62576520
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.62375620
37LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56669614
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.55576166
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53858170
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.53415284
41HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.52919069
42SOX2_16153702_ChIP-ChIP_HESCs_Human1.49256019
43EWS_26573619_Chip-Seq_HEK293_Human1.46848033
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46730485
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42449920
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41529618
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40966816
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37441317
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.33501713
50BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.33334901
51RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32349104
52TP53_16413492_ChIP-PET_HCT116_Human1.30474953
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27914103
54PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26599034
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.24933876
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24856418
57PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.23947553
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23778189
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22646337
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22454008
61JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22027359
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20938567
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20938567
64CBP_20019798_ChIP-Seq_JUKART_Human1.20836732
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20836732
66GATA3_27048872_Chip-Seq_THYMUS_Human1.18579913
67GATA1_19941826_ChIP-Seq_K562_Human1.17693221
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16842789
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15284121
70SOX9_26525672_Chip-Seq_HEART_Mouse1.14181228
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11947339
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11531605
73E2F1_20622854_ChIP-Seq_HELA_Human1.11520747
74SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10097576
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07380753
76SPI1_23127762_ChIP-Seq_K562_Human1.04888901
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02652405
78TAF2_19829295_ChIP-Seq_ESCs_Human0.99488304
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98061134
80HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96734517
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96663276
82GATA3_26560356_Chip-Seq_TH2_Human0.96660197
83HTT_18923047_ChIP-ChIP_STHdh_Human0.95652980
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94727809
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93840342
86ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93136682
87NCOR_22424771_ChIP-Seq_293T_Human0.92709031
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91727578
89ESR1_20079471_ChIP-ChIP_T-47D_Human0.91269924
90GATA6_21074721_ChIP-Seq_CACO-2_Human0.90967752
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.89907923
92TFEB_21752829_ChIP-Seq_HELA_Human0.89186486
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88282433
94YY1_21170310_ChIP-Seq_MESCs_Mouse0.86019473
95SALL4_22934838_ChIP-ChIP_CD34+_Human0.84120051
96ERA_21632823_ChIP-Seq_H3396_Human0.82337353
97RBPJ_21746931_ChIP-Seq_IB4_Human0.82085415
98CEBPB_22108803_ChIP-Seq_LS180_Human0.80576824
99TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.79787092
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.79678824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system9.26616019
2MP0004381_abnormal_hair_follicle5.58130571
3MP0008057_abnormal_DNA_replication4.80457079
4MP0005075_abnormal_melanosome_morpholog4.32384225
5MP0004147_increased_porphyrin_level4.25432939
6MP0002638_abnormal_pupillary_reflex3.28766256
7MP0001835_abnormal_antigen_presentation3.06622174
8MP0005167_abnormal_blood-brain_barrier3.06021417
9MP0008875_abnormal_xenobiotic_pharmacok2.97636816
10MP0004858_abnormal_nervous_system2.96050144
11MP0002166_altered_tumor_susceptibility2.92028170
12MP0001853_heart_inflammation2.79881571
13MP0002254_reproductive_system_inflammat2.78515076
14MP0001542_abnormal_bone_strength2.71557624
15MP0005360_urolithiasis2.61982974
16MP0002006_tumorigenesis2.53215425
17MP0010234_abnormal_vibrissa_follicle2.20506044
18MP0000647_abnormal_sebaceous_gland2.08390915
19MP0003879_abnormal_hair_cell2.03171417
20MP0004043_abnormal_pH_regulation1.97487065
21MP0006276_abnormal_autonomic_nervous1.75420993
22MP0003195_calcinosis1.75173807
23MP0006054_spinal_hemorrhage1.74346357
24MP0008995_early_reproductive_senescence1.59630374
25MP0003646_muscle_fatigue1.58051469
26MP0000685_abnormal_immune_system1.52828795
27MP0002277_abnormal_respiratory_mucosa1.46415692
28MP0008961_abnormal_basal_metabolism1.45427049
29MP0005535_abnormal_body_temperature1.44746986
30MP0003172_abnormal_lysosome_physiology1.26442864
31MP0001502_abnormal_circadian_rhythm1.23980582
32MP0005220_abnormal_exocrine_pancreas1.23875454
33MP0001501_abnormal_sleep_pattern1.20591569
34MP0003786_premature_aging1.19561853
35MP0009785_altered_susceptibility_to1.14669394
36MP0002089_abnormal_postnatal_growth/wei1.13163432
37MP0002653_abnormal_ependyma_morphology1.12440175
38MP0005645_abnormal_hypothalamus_physiol1.10654549
39MP0001188_hyperpigmentation1.08251683
40MP0002796_impaired_skin_barrier1.08245051
41MP0001849_ear_inflammation0.93907031
42MP0003787_abnormal_imprinting0.92657110
43MP0001727_abnormal_embryo_implantation0.91802429
44MP0005310_abnormal_salivary_gland0.88919173
45MP0005623_abnormal_meninges_morphology0.86511527
46MP0005365_abnormal_bile_salt0.85562475
47MP0000427_abnormal_hair_cycle0.83212378
48MP0008770_decreased_survivor_rate0.80004600
49MP0004947_skin_inflammation0.77747853
50MP0000013_abnormal_adipose_tissue0.77023336
51MP0003698_abnormal_male_reproductive0.76696890
52MP0000613_abnormal_salivary_gland0.76563624
53MP0005646_abnormal_pituitary_gland0.73900210
54MP0003724_increased_susceptibility_to0.73437730
55MP0002295_abnormal_pulmonary_circulatio0.73024418
56MP0002405_respiratory_system_inflammati0.72327334
57MP0001929_abnormal_gametogenesis0.72130824
58MP0005551_abnormal_eye_electrophysiolog0.69838351
59MP0000372_irregular_coat_pigmentation0.69600557
60MP0004142_abnormal_muscle_tone0.69197979
61MP0001873_stomach_inflammation0.67433617
62MP0005266_abnormal_metabolism0.67419997
63MP0002971_abnormal_brown_adipose0.66712450
64MP0009643_abnormal_urine_homeostasis0.65846221
65MP0001243_abnormal_dermal_layer0.65078177
66MP0006292_abnormal_olfactory_placode0.64751448
67MP0008775_abnormal_heart_ventricle0.64087227
68MP0002210_abnormal_sex_determination0.61573916
69MP0008872_abnormal_physiological_respon0.57991322
70MP0004270_analgesia0.57580725
71MP0001145_abnormal_male_reproductive0.56309742
72MP0002090_abnormal_vision0.54709767
73MP0001968_abnormal_touch/_nociception0.53486295
74MP0005253_abnormal_eye_physiology0.51802089
75MP0009745_abnormal_behavioral_response0.50101875
76MP0002229_neurodegeneration0.49993950
77MP0004085_abnormal_heartbeat0.49186267
78MP0003866_abnormal_defecation0.48582431
79MP0005636_abnormal_mineral_homeostasis0.47529056
80MP0000653_abnormal_sex_gland0.46419926
81MP0004215_abnormal_myocardial_fiber0.46392161
82MP0000377_abnormal_hair_follicle0.44842678
83MP0001293_anophthalmia0.44460054
84MP0001756_abnormal_urination0.42707086
85MP0004484_altered_response_of0.41519781
86MP0003011_delayed_dark_adaptation0.41299862
87MP0005410_abnormal_fertilization0.40801663
88MP0005387_immune_system_phenotype0.40605312
89MP0001790_abnormal_immune_system0.40605312
90MP0003693_abnormal_embryo_hatching0.39024742
91MP0008007_abnormal_cellular_replicative0.38926501
92MP0005647_abnormal_sex_gland0.38018138
93MP0001765_abnormal_ion_homeostasis0.36679314
94MP0000609_abnormal_liver_physiology0.36408869
95MP0005501_abnormal_skin_physiology0.35824195
96MP0002136_abnormal_kidney_physiology0.35679059
97MP0002837_dystrophic_cardiac_calcinosis0.34670075
98MP0004130_abnormal_muscle_cell0.34654310
99MP0004510_myositis0.34043104
100MP0006035_abnormal_mitochondrial_morpho0.33625367

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)9.52390772
2Large eyes (HP:0001090)8.98969908
3Abnormality of the fingertips (HP:0001211)6.41834595
4Chronic otitis media (HP:0000389)6.12639608
5Reduced subcutaneous adipose tissue (HP:0003758)5.52695934
63-Methylglutaconic aciduria (HP:0003535)5.28377604
7Abnormality of alanine metabolism (HP:0010916)5.14785600
8Hyperalaninemia (HP:0003348)5.14785600
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.14785600
10Delayed CNS myelination (HP:0002188)4.92110042
11Type II lissencephaly (HP:0007260)4.64731753
12Cerebellar dysplasia (HP:0007033)4.56077202
13Chronic sinusitis (HP:0011109)4.07508076
14Nasal polyposis (HP:0100582)3.85984498
15Clubbing of toes (HP:0100760)3.82208215
16Basal ganglia calcification (HP:0002135)3.65044076
17Macroglossia (HP:0000158)3.60056271
18Abnormality of the peritoneum (HP:0002585)3.57384950
19Ileus (HP:0002595)3.50303749
20Chronic hepatic failure (HP:0100626)3.41103686
21Decreased circulating renin level (HP:0003351)3.13615789
22Microcytic anemia (HP:0001935)3.13612395
23Pancreatic cysts (HP:0001737)3.08417556
24Abnormality of the nasal mucosa (HP:0000433)3.05423089
25Azoospermia (HP:0000027)2.97492991
26Abnormality of the vitamin B12 metabolism (HP:0004341)2.94729627
27Mediastinal lymphadenopathy (HP:0100721)2.91344068
28Tubulointerstitial nephritis (HP:0001970)2.87644948
29Abnormality of vitamin B metabolism (HP:0004340)2.79863622
30Atonic seizures (HP:0010819)2.79331189
31Prominent nose (HP:0000448)2.73180213
32Febrile seizures (HP:0002373)2.64055431
33Retinal dysplasia (HP:0007973)2.60031122
34Testicular atrophy (HP:0000029)2.58870835
35Multiple enchondromatosis (HP:0005701)2.58143265
36Hyperkalemia (HP:0002153)2.54770114
37Flat occiput (HP:0005469)2.50354392
38Arthropathy (HP:0003040)2.50169741
39Congenital stationary night blindness (HP:0007642)2.49140069
40Cardiomegaly (HP:0001640)2.49083141
41Hyperglycinemia (HP:0002154)2.48344303
42Pancreatic fibrosis (HP:0100732)2.44369531
43Microretrognathia (HP:0000308)2.33786683
44Abnormality of the basal ganglia (HP:0002134)2.32600040
45Attenuation of retinal blood vessels (HP:0007843)2.31492213
46Erythema (HP:0010783)2.29812384
47Recurrent bronchitis (HP:0002837)2.29506816
48Hypothermia (HP:0002045)2.29171252
49True hermaphroditism (HP:0010459)2.27633344
50Abnormality of the pleura (HP:0002103)2.23649224
51Generalized aminoaciduria (HP:0002909)2.15094122
52Methylmalonic acidemia (HP:0002912)2.06256822
53Congenital primary aphakia (HP:0007707)2.05718314
54Joint contractures involving the joints of the feet (HP:0100492)2.02207215
55Flexion contracture of toe (HP:0005830)2.02207215
56Gaze-evoked nystagmus (HP:0000640)2.00032699
57Gait imbalance (HP:0002141)1.99376157
58Calf muscle hypertrophy (HP:0008981)1.98007356
59Hypergammaglobulinemia (HP:0010702)1.97942260
60Hypoplasia of the pons (HP:0012110)1.97133660
61Thyroid carcinoma (HP:0002890)1.97079634
62Increased neuronal autofluorescent lipopigment (HP:0002074)1.96897201
63Bronchitis (HP:0012387)1.95635475
64Medial flaring of the eyebrow (HP:0010747)1.94547168
65Hydroxyprolinuria (HP:0003080)1.91766954
66Abnormality of proline metabolism (HP:0010907)1.91766954
67Abnormal spermatogenesis (HP:0008669)1.91634174
68Abnormality of vitamin metabolism (HP:0100508)1.89954203
69Abnormality of serum amino acid levels (HP:0003112)1.84673597
70Elbow flexion contracture (HP:0002987)1.84289935
71Papillary thyroid carcinoma (HP:0002895)1.83274540
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82452991
73Bronchiectasis (HP:0002110)1.81651306
74Nephrogenic diabetes insipidus (HP:0009806)1.79755594
75Abnormal drinking behavior (HP:0030082)1.76866165
76Polydipsia (HP:0001959)1.76866165
77Hypokalemic alkalosis (HP:0001949)1.76268574
78Abnormality of the pons (HP:0007361)1.75954626
79Muscle hypertrophy of the lower extremities (HP:0008968)1.74270215
80Status epilepticus (HP:0002133)1.74143793
81Lymphedema (HP:0001004)1.73141522
82Absence seizures (HP:0002121)1.71676029
83Cone-rod dystrophy (HP:0000548)1.71389594
84Abnormality of glycine metabolism (HP:0010895)1.70778990
85Abnormality of serine family amino acid metabolism (HP:0010894)1.70778990
86Methylmalonic aciduria (HP:0012120)1.69778975
87Hypertriglyceridemia (HP:0002155)1.68108205
88Acute lymphatic leukemia (HP:0006721)1.68098087
89Aplasia/Hypoplasia of the lens (HP:0008063)1.67646775
90Clumsiness (HP:0002312)1.67276750
91Trismus (HP:0000211)1.67170522
92Aplastic anemia (HP:0001915)1.65846019
93Abnormality of chloride homeostasis (HP:0011422)1.65710982
94Thin upper lip vermilion (HP:0000219)1.65685403
95Cystic liver disease (HP:0006706)1.65165482
96Hyperaldosteronism (HP:0000859)1.63594384
97Lissencephaly (HP:0001339)1.63136471
98Abnormality of renin-angiotensin system (HP:0000847)1.62049691
99Occipital encephalocele (HP:0002085)1.60696032
100Short foot (HP:0001773)1.59327407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.25564014
2SIK23.98638975
3ACVR1B3.48545181
4CHUK2.92354658
5IRAK12.87470332
6ZAK2.87262081
7TLK12.77780611
8MARK32.67174985
9WNK42.55010053
10MST42.35311586
11FER2.33041661
12MAP3K52.11597090
13KSR12.07508731
14AKT31.96605099
15IKBKB1.91122768
16EPHA31.91086182
17SIK31.82544004
18MAP3K21.82321499
19MKNK21.69066462
20CDK121.67816029
21DYRK31.62319826
22RPS6KA51.61666869
23NLK1.51589185
24IRAK21.47555464
25ADRBK21.47499657
26PKN11.43165504
27ABL21.41367325
28CDK91.30201828
29DYRK1B1.26595176
30MAP3K91.23480357
31KSR21.21192506
32DYRK1A1.19709878
33MAP3K141.18564835
34STK111.15805805
35NUAK11.14661852
36PRKAA11.13770727
37ATR1.09976315
38EPHB11.09890194
39SRPK11.08268968
40CSNK1G11.06123150
41VRK11.04749648
42CSNK1G31.03314702
43MKNK10.97717050
44MAP4K20.96291114
45DYRK20.91309631
46MAP3K130.87307968
47SIK10.85492658
48BCKDK0.80536266
49PIM10.80134411
50CSNK1G20.77570634
51IKBKE0.77264118
52BMPR1B0.75502247
53CAMK1D0.75160909
54PIK3CG0.72305560
55ERBB30.70612151
56TAOK10.70375544
57RPS6KA10.68751704
58TRPM70.66532041
59FGFR30.66047137
60CAMK10.65913428
61BRD40.65253316
62STK40.61546870
63EIF2AK30.57838732
64ARAF0.57105770
65STK38L0.56878006
66BRAF0.55943696
67WNK30.55879307
68MAP2K10.55339299
69TYRO30.55189211
70ATM0.53922251
71STK30.53821699
72GRK10.51196411
73ERBB20.49117823
74EPHA40.47485566
75WNK10.45661861
76LATS10.44057181
77MAPK110.43029711
78MAP3K80.41449800
79PAK60.41409179
80TEC0.41273406
81PAK10.40418123
82TXK0.39383878
83MUSK0.39139945
84CSNK1E0.37316802
85OXSR10.35727152
86ADRBK10.35267542
87DAPK20.35018920
88AURKB0.34728423
89CSNK1A1L0.34406677
90PRKG10.33155885
91RAF10.30981338
92MINK10.29387936
93JAK20.29114164
94CSNK1D0.28923649
95PAK30.28806061
96PRKCI0.28694247
97TAOK30.27491902
98MAPK10.27475479
99TIE10.25590039
100CHEK10.24786763

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053228.14152714
2Alcoholism_Homo sapiens_hsa050345.40530743
3Viral carcinogenesis_Homo sapiens_hsa052033.49799683
4Fatty acid elongation_Homo sapiens_hsa000622.95070610
5SNARE interactions in vesicular transport_Homo sapiens_hsa041302.76363465
6Nitrogen metabolism_Homo sapiens_hsa009102.45651860
7Allograft rejection_Homo sapiens_hsa053302.40986617
8Graft-versus-host disease_Homo sapiens_hsa053322.38858424
9Autoimmune thyroid disease_Homo sapiens_hsa053202.09099006
10Type I diabetes mellitus_Homo sapiens_hsa049402.01847202
11Staphylococcus aureus infection_Homo sapiens_hsa051502.01735830
12Propanoate metabolism_Homo sapiens_hsa006401.99335438
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.74965443
14Circadian rhythm_Homo sapiens_hsa047101.50726099
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50514993
16ABC transporters_Homo sapiens_hsa020101.49585505
17Antigen processing and presentation_Homo sapiens_hsa046121.43661467
18Asthma_Homo sapiens_hsa053101.40382934
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.39821011
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38950548
21p53 signaling pathway_Homo sapiens_hsa041151.38002023
22RNA polymerase_Homo sapiens_hsa030201.29926410
23Taste transduction_Homo sapiens_hsa047421.26960631
24mRNA surveillance pathway_Homo sapiens_hsa030151.19726536
25beta-Alanine metabolism_Homo sapiens_hsa004101.14887823
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13293209
27Olfactory transduction_Homo sapiens_hsa047401.11548276
28Proteasome_Homo sapiens_hsa030501.09871903
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08975089
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08127822
31Herpes simplex infection_Homo sapiens_hsa051681.07868385
32Tryptophan metabolism_Homo sapiens_hsa003801.02118163
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01013196
34Selenocompound metabolism_Homo sapiens_hsa004501.00648680
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99364882
36Lysine degradation_Homo sapiens_hsa003100.96702360
37Butanoate metabolism_Homo sapiens_hsa006500.86734633
38Arginine and proline metabolism_Homo sapiens_hsa003300.84215836
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83116708
40Viral myocarditis_Homo sapiens_hsa054160.83009754
41Phototransduction_Homo sapiens_hsa047440.81733295
42Dorso-ventral axis formation_Homo sapiens_hsa043200.74225320
43Serotonergic synapse_Homo sapiens_hsa047260.73505716
44Prolactin signaling pathway_Homo sapiens_hsa049170.73332763
45FoxO signaling pathway_Homo sapiens_hsa040680.73235863
46Basal transcription factors_Homo sapiens_hsa030220.71761837
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71697374
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.71390236
49Legionellosis_Homo sapiens_hsa051340.68182823
50Linoleic acid metabolism_Homo sapiens_hsa005910.68024576
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67510164
52One carbon pool by folate_Homo sapiens_hsa006700.65955871
53Fanconi anemia pathway_Homo sapiens_hsa034600.63182419
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62785637
55Leishmaniasis_Homo sapiens_hsa051400.62191994
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59385303
57Primary immunodeficiency_Homo sapiens_hsa053400.56157557
58Homologous recombination_Homo sapiens_hsa034400.53231922
59DNA replication_Homo sapiens_hsa030300.50645228
60Rheumatoid arthritis_Homo sapiens_hsa053230.50038453
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.48784928
62Synaptic vesicle cycle_Homo sapiens_hsa047210.47756311
63Phagosome_Homo sapiens_hsa041450.47479552
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46369497
65Purine metabolism_Homo sapiens_hsa002300.45709228
66Protein digestion and absorption_Homo sapiens_hsa049740.45233561
67Protein export_Homo sapiens_hsa030600.42431255
68RNA transport_Homo sapiens_hsa030130.41696617
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40415736
70Epstein-Barr virus infection_Homo sapiens_hsa051690.37933963
71Bile secretion_Homo sapiens_hsa049760.37087273
72Retinol metabolism_Homo sapiens_hsa008300.36711927
73Malaria_Homo sapiens_hsa051440.35967964
74Salivary secretion_Homo sapiens_hsa049700.34702480
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33543614
76Morphine addiction_Homo sapiens_hsa050320.33536737
77Hematopoietic cell lineage_Homo sapiens_hsa046400.32999274
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32726704
79Nicotine addiction_Homo sapiens_hsa050330.31992134
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31017287
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30717640
82Caffeine metabolism_Homo sapiens_hsa002320.28181296
83Dopaminergic synapse_Homo sapiens_hsa047280.26997016
84Peroxisome_Homo sapiens_hsa041460.24018632
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23974847
86Pyrimidine metabolism_Homo sapiens_hsa002400.22505849
87Circadian entrainment_Homo sapiens_hsa047130.21999211
88Sulfur relay system_Homo sapiens_hsa041220.21990697
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21827196
90Long-term depression_Homo sapiens_hsa047300.21755701
91Tuberculosis_Homo sapiens_hsa051520.21741901
92Type II diabetes mellitus_Homo sapiens_hsa049300.20464622
93African trypanosomiasis_Homo sapiens_hsa051430.19857748
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19556776
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19454286
96Chemical carcinogenesis_Homo sapiens_hsa052040.18161981
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.17602144
98Collecting duct acid secretion_Homo sapiens_hsa049660.17270814
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16106385
100Spliceosome_Homo sapiens_hsa030400.14716988

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »