USP9Y

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the peptidase C19 family. It encodes a protein that is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.66759505
2regulation of meiosis I (GO:0060631)9.18695737
3meiotic nuclear division (GO:0007126)7.99849982
4chromosome organization involved in meiosis (GO:0070192)7.87273869
5male meiosis I (GO:0007141)7.60363763
6meiosis I (GO:0007127)6.49007455
7gene silencing by RNA (GO:0031047)5.79535494
8meiotic cell cycle process (GO:1903046)5.61787759
9DNA methylation (GO:0006306)5.50812910
10DNA alkylation (GO:0006305)5.50812910
11meiotic chromosome segregation (GO:0045132)5.47778474
12reciprocal DNA recombination (GO:0035825)5.45742243
13reciprocal meiotic recombination (GO:0007131)5.45742243
14positive regulation of meiosis (GO:0045836)5.41013951
15positive regulation of meiotic cell cycle (GO:0051446)5.13634174
16oogenesis (GO:0048477)5.10026839
17nuclear pore complex assembly (GO:0051292)5.06242257
18nuclear pore organization (GO:0006999)5.01149898
19fusion of sperm to egg plasma membrane (GO:0007342)4.99390109
20attachment of spindle microtubules to kinetochore (GO:0008608)4.89239905
21synapsis (GO:0007129)4.66050819
22negative regulation of meiosis (GO:0045835)4.64493402
23presynaptic membrane assembly (GO:0097105)4.54817913
24neuron cell-cell adhesion (GO:0007158)4.52933696
25DNA synthesis involved in DNA repair (GO:0000731)4.36474134
26sister chromatid cohesion (GO:0007062)4.35824213
27pyrimidine nucleobase catabolic process (GO:0006208)4.32202764
28DNA replication checkpoint (GO:0000076)4.26235407
29DNA methylation or demethylation (GO:0044728)4.22009728
30resolution of meiotic recombination intermediates (GO:0000712)4.20026878
31gene silencing (GO:0016458)4.19223405
32oocyte maturation (GO:0001556)4.15669192
33heterochromatin organization (GO:0070828)4.13350164
34cilium or flagellum-dependent cell motility (GO:0001539)4.12877597
35establishment of protein localization to Golgi (GO:0072600)4.12827925
36presynaptic membrane organization (GO:0097090)4.08478184
37positive regulation of translational initiation (GO:0045948)4.03221894
38spermatid development (GO:0007286)4.03169189
39pore complex assembly (GO:0046931)3.92103314
40germ cell development (GO:0007281)3.90482760
41protein targeting to Golgi (GO:0000042)3.89846179
42sex differentiation (GO:0007548)3.89092205
43kinetochore organization (GO:0051383)3.84872685
44protein K6-linked ubiquitination (GO:0085020)3.81940934
45oocyte development (GO:0048599)3.80748692
46microtubule depolymerization (GO:0007019)3.80007239
47female gamete generation (GO:0007292)3.76660106
48meiotic cell cycle (GO:0051321)3.72239271
49mitotic metaphase plate congression (GO:0007080)3.71518087
50plasma membrane fusion (GO:0045026)3.64778970
51DNA replication-dependent nucleosome organization (GO:0034723)3.64119564
52DNA replication-dependent nucleosome assembly (GO:0006335)3.64119564
53retrograde transport, vesicle recycling within Golgi (GO:0000301)3.63490546
54metaphase plate congression (GO:0051310)3.61687125
55kinetochore assembly (GO:0051382)3.59906028
56response to pheromone (GO:0019236)3.56301018
57histone H4-K12 acetylation (GO:0043983)3.54523607
58DNA modification (GO:0006304)3.54314282
59* spermatogenesis (GO:0007283)3.53485049
60* male gamete generation (GO:0048232)3.53286001
61auditory behavior (GO:0031223)3.52953604
62regulation of double-strand break repair via homologous recombination (GO:0010569)3.52913915
63sperm motility (GO:0030317)3.51627304
64mitotic chromosome condensation (GO:0007076)3.50542815
65sperm-egg recognition (GO:0035036)3.50532126
66monoubiquitinated protein deubiquitination (GO:0035520)3.48895437
67neuronal action potential propagation (GO:0019227)3.47045219
68binding of sperm to zona pellucida (GO:0007339)3.46962607
69neural tube formation (GO:0001841)3.45708254
70regulation of meiosis (GO:0040020)3.43982747
71inner cell mass cell proliferation (GO:0001833)3.43055983
72acrosome assembly (GO:0001675)3.41236126
73protein localization to cilium (GO:0061512)3.40732915
74histone exchange (GO:0043486)3.36407338
75negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.34487923
76negative regulation of translation, ncRNA-mediated (GO:0040033)3.34487923
77regulation of translation, ncRNA-mediated (GO:0045974)3.34487923
78nucleobase catabolic process (GO:0046113)3.34459742
79regulation of chromosome segregation (GO:0051983)3.32054681
80protein localization to synapse (GO:0035418)3.31090924
81neurotransmitter-gated ion channel clustering (GO:0072578)3.29940197
82* gamete generation (GO:0007276)3.29593093
83axonal fasciculation (GO:0007413)3.28531620
84mitotic spindle assembly checkpoint (GO:0007094)3.25904595
85mitotic spindle checkpoint (GO:0071174)3.25631528
86negative regulation of chromosome segregation (GO:0051985)3.25204222
87regulation of centriole replication (GO:0046599)3.23421321
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22833526
89negative regulation of sister chromatid segregation (GO:0033046)3.22833526
90negative regulation of mitotic sister chromatid separation (GO:2000816)3.22833526
91negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22833526
92cellular process involved in reproduction in multicellular organism (GO:0022412)3.22604761
93regulation of mitotic metaphase/anaphase transition (GO:0030071)3.21687010
94chromosome organization (GO:0051276)3.20763808
95spindle assembly checkpoint (GO:0071173)3.20752516
96spindle checkpoint (GO:0031577)3.20635234
97nuclear division (GO:0000280)3.19669780
98phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.17687679
99cell-cell recognition (GO:0009988)3.15967973
100chromatin remodeling at centromere (GO:0031055)3.14238183
101regulation of histone H3-K9 methylation (GO:0051570)3.13982109
102regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13237885
103membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12998371
104positive regulation of male gonad development (GO:2000020)3.12670765
105regulation of glucokinase activity (GO:0033131)3.12386949
106regulation of hexokinase activity (GO:1903299)3.12386949
107regulation of RNA export from nucleus (GO:0046831)3.12363841
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11865642
109synapse assembly (GO:0007416)3.11412815
110regulation of double-strand break repair (GO:2000779)3.09790385
111regulation of mitotic sister chromatid separation (GO:0010965)3.08685418
112regulation of mitotic sister chromatid segregation (GO:0033047)3.08685418
113regulation of sister chromatid segregation (GO:0033045)3.08685418
114neuronal action potential (GO:0019228)3.07622920
115postsynaptic membrane organization (GO:0001941)3.06634358
116vocalization behavior (GO:0071625)3.05551870
117gamma-aminobutyric acid transport (GO:0015812)3.02774390
118protein localization to Golgi apparatus (GO:0034067)3.02200185
119regulation of action potential (GO:0098900)3.00576529
120mitotic nuclear envelope disassembly (GO:0007077)3.00320816
121DNA packaging (GO:0006323)2.98607659
122positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.94954003
123inositol phosphate catabolic process (GO:0071545)2.94585417
124neuron recognition (GO:0008038)2.94417395
125axonemal dynein complex assembly (GO:0070286)2.92888341
126organelle fission (GO:0048285)2.91851432
127negative regulation of nuclear division (GO:0051784)2.91065714
128epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90141581
129histone H4-K5 acetylation (GO:0043981)2.89436270
130histone H4-K8 acetylation (GO:0043982)2.89436270
131behavioral response to nicotine (GO:0035095)2.86228028
132regulation of sarcomere organization (GO:0060297)2.84647134
133mechanosensory behavior (GO:0007638)2.82885036
134positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.75059848
135calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.73444172
136righting reflex (GO:0060013)2.73285847
137G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.71010898
138membrane depolarization during action potential (GO:0086010)2.68977730
139glutamate receptor signaling pathway (GO:0007215)2.67351825
140proline transport (GO:0015824)2.66284082
141mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.66281712
142positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.66281712
143head development (GO:0060322)2.66221981
144protein K11-linked deubiquitination (GO:0035871)2.65836708
145glycosphingolipid biosynthetic process (GO:0006688)2.64875130
146interkinetic nuclear migration (GO:0022027)2.64067010
147reflex (GO:0060004)2.61950071
148negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.61576006
149intra-Golgi vesicle-mediated transport (GO:0006891)2.61416399
150indolalkylamine metabolic process (GO:0006586)2.60658406
151ionotropic glutamate receptor signaling pathway (GO:0035235)2.59286108
152polyol catabolic process (GO:0046174)2.58838797
153synaptic transmission, glutamatergic (GO:0035249)2.58625427
154inositol phosphate dephosphorylation (GO:0046855)2.57140482
155phosphorylated carbohydrate dephosphorylation (GO:0046838)2.57140482
156synaptic vesicle maturation (GO:0016188)2.53339631
157response to auditory stimulus (GO:0010996)2.51936354
158negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51666232
159regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.50423309
160intraciliary transport (GO:0042073)2.49084578
161epithelial cilium movement (GO:0003351)2.48340938
162regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.47941264
163regulation of short-term neuronal synaptic plasticity (GO:0048172)2.47684956
164neuron-neuron synaptic transmission (GO:0007270)2.44494654
165cerebral cortex radially oriented cell migration (GO:0021799)2.43793872
166negative regulation of mast cell activation (GO:0033004)2.43661724
167dendrite morphogenesis (GO:0048813)2.42990701
168regulation of feeding behavior (GO:0060259)2.41186506
169synapse organization (GO:0050808)2.38249895
170tachykinin receptor signaling pathway (GO:0007217)2.37865193
171inner ear receptor stereocilium organization (GO:0060122)2.37377122
172kidney morphogenesis (GO:0060993)2.36845708
173negative regulation of synaptic transmission, GABAergic (GO:0032229)2.36604410
174nucleus localization (GO:0051647)2.34086238
175artery development (GO:0060840)2.34062257
176regulation of synaptic transmission, glutamatergic (GO:0051966)2.32868619
177atrial cardiac muscle cell action potential (GO:0086014)2.32125681
178regulation of cell communication by electrical coupling (GO:0010649)2.31743703
179homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.31739682
180establishment of nucleus localization (GO:0040023)2.30610229
181cilium morphogenesis (GO:0060271)2.30379547
182C4-dicarboxylate transport (GO:0015740)2.30106392
183positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.28899401
184central nervous system projection neuron axonogenesis (GO:0021952)2.27492260
185regulation of vesicle fusion (GO:0031338)2.26533705
186central nervous system neuron axonogenesis (GO:0021955)2.26018697
187water-soluble vitamin biosynthetic process (GO:0042364)2.25917170
188action potential (GO:0001508)2.25373310
189early endosome to late endosome transport (GO:0045022)2.24952224
190positive regulation of oligodendrocyte differentiation (GO:0048714)2.24557849
191cilium organization (GO:0044782)2.23625314
192cilium movement (GO:0003341)2.23473015
193transepithelial transport (GO:0070633)2.23025068
194cerebral cortex cell migration (GO:0021795)2.22230052
195piRNA metabolic process (GO:0034587)14.4813765
196DNA methylation involved in gamete generation (GO:0043046)11.5518887
197synaptonemal complex assembly (GO:0007130)10.9193840
198synaptonemal complex organization (GO:0070193)10.2338930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.85889789
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.59276774
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.18867582
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.94367296
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.61541003
6IGF1R_20145208_ChIP-Seq_DFB_Human3.43545151
7GBX2_23144817_ChIP-Seq_PC3_Human3.41426275
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.07120024
9* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.98402991
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.97946036
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93451428
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92385229
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.85614689
14EZH2_22144423_ChIP-Seq_EOC_Human2.71677550
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.70171125
16AR_21909140_ChIP-Seq_LNCAP_Human2.69829971
17ZNF274_21170338_ChIP-Seq_K562_Hela2.58109245
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.44558326
19MYCN_18555785_ChIP-Seq_MESCs_Mouse2.41093481
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40783398
21PIAS1_25552417_ChIP-Seq_VCAP_Human2.35578379
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.31527177
23TAF15_26573619_Chip-Seq_HEK293_Human2.28738372
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.23529251
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.22360439
26VDR_22108803_ChIP-Seq_LS180_Human2.21837501
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21651424
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19201711
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15711602
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.15498162
31P300_19829295_ChIP-Seq_ESCs_Human2.15034694
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13814591
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12018934
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08121728
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.03492645
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03139307
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.02151447
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.02151447
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.02151447
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.99941343
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.98780621
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.98581048
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.96896228
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93427025
45AR_21572438_ChIP-Seq_LNCaP_Human1.92995418
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.90348317
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90178279
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89110356
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.87984209
50SMAD4_21799915_ChIP-Seq_A2780_Human1.86344580
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83593612
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79980569
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77792310
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76920078
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.76187180
56STAT3_23295773_ChIP-Seq_U87_Human1.73413446
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72734597
58* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.71551118
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65562676
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64866841
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64193432
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.62425093
63XRN2_22483619_ChIP-Seq_HELA_Human1.62158378
64EWS_26573619_Chip-Seq_HEK293_Human1.61598794
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.61545648
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.60839130
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60153491
68AR_25329375_ChIP-Seq_VCAP_Human1.59262637
69VDR_23849224_ChIP-Seq_CD4+_Human1.58375921
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56475627
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.56080558
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55464461
73RNF2_27304074_Chip-Seq_NSC_Mouse1.55039355
74TCF4_23295773_ChIP-Seq_U87_Human1.52780773
75ER_23166858_ChIP-Seq_MCF-7_Human1.50249513
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48725659
77KDM5A_27292631_Chip-Seq_BREAST_Human1.48679741
78DCP1A_22483619_ChIP-Seq_HELA_Human1.46327051
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45649691
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45462177
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44406993
82REST_21632747_ChIP-Seq_MESCs_Mouse1.44383614
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43193249
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42489116
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41863462
86GABP_19822575_ChIP-Seq_HepG2_Human1.40055966
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38726252
88RUNX2_22187159_ChIP-Seq_PCA_Human1.36360759
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.35705955
90HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33437183
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.33357589
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33226759
93CBP_20019798_ChIP-Seq_JUKART_Human1.33226759
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33117495
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33056172
96BCAT_22108803_ChIP-Seq_LS180_Human1.31730673
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31499699
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.31360495
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30286322
100RUNX1_26923725_Chip-Seq_HPCs_Mouse1.29142034
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28571107
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27773938
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27773938
104FOXP3_21729870_ChIP-Seq_TREG_Human1.25345716
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25121372
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24816819
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.24697948
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.24012282
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.23954305
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23919445
111KAP1_22055183_ChIP-Seq_ESCs_Mouse1.23167031
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22913021
113ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22477354
114IRF1_19129219_ChIP-ChIP_H3396_Human1.22170782
115TCF4_22108803_ChIP-Seq_LS180_Human1.19951090
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19782096
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.18316401
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18249377
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.16874109
120SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16364700
121THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16044678
122EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16015106
123TAL1_26923725_Chip-Seq_HPCs_Mouse1.15626023
124KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15149957
125P53_22387025_ChIP-Seq_ESCs_Mouse1.15135173
126KDM2B_26808549_Chip-Seq_REH_Human1.14276825
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14268660
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13991606
129NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13991606
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13332763
131E2F1_18555785_Chip-Seq_ESCs_Mouse1.13213031
132AHR_22903824_ChIP-Seq_MCF-7_Human1.12309284
133DROSHA_22980978_ChIP-Seq_HELA_Human1.12186807
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11115135
135PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09647629
136E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09646950
137SOX2_19829295_ChIP-Seq_ESCs_Human1.07272345
138NANOG_19829295_ChIP-Seq_ESCs_Human1.07272345
139CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06439317
140RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06079137
141TTF2_22483619_ChIP-Seq_HELA_Human1.05152057
142SMAD4_21741376_ChIP-Seq_EPCs_Human1.04573985
143CMYC_18555785_Chip-Seq_ESCs_Mouse1.04245470
144TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03596877
145CRX_20693478_ChIP-Seq_RETINA_Mouse1.02730611
146TP53_16413492_ChIP-PET_HCT116_Human1.02523436
147CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01944577
148JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01685095
149BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00414045
150CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99753082
151TP63_19390658_ChIP-ChIP_HaCaT_Human0.99034102
152LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99024173
153STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97324902
154E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95588496
155SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95465410
156YY1_21170310_ChIP-Seq_MESCs_Mouse0.94136370
157CIITA_25753668_ChIP-Seq_RAJI_Human0.90470283
158HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90009647
159MYC_18940864_ChIP-ChIP_HL60_Human0.85887817
160DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84091289
161ELK1_19687146_ChIP-ChIP_HELA_Human0.81005779
162TFEB_21752829_ChIP-Seq_HELA_Human0.79507011
163NFE2_27457419_Chip-Seq_LIVER_Mouse0.78785473
164NOTCH1_21737748_ChIP-Seq_TLL_Human0.78521254
165GATA3_21867929_ChIP-Seq_TH1_Mouse0.78102468
166RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.77097997
167SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.75699657
168PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75271606
169SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73243467
170FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72900962
171PCGF2_27294783_Chip-Seq_NPCs_Mouse0.72393548
172ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.72290438
173ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.71604424
174* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.69657574
175* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.69269148
176PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.68935067
177FUS_26573619_Chip-Seq_HEK293_Human0.67396299
178LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.67212464
179OCT4_19829295_ChIP-Seq_ESCs_Human0.64810975
180LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.63932314
181ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.63922912
182ETV1_20927104_ChIP-Seq_GIST48_Human0.63378110
183STAT6_21828071_ChIP-Seq_BEAS2B_Human0.63340187
184ELK4_26923725_Chip-Seq_MESODERM_Mouse0.63186809
185TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.61450034
186SOX2_21211035_ChIP-Seq_LN229_Human0.60791418
187HOXB7_26014856_ChIP-Seq_BT474_Human0.60397220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence5.92363475
2MP0002210_abnormal_sex_determination4.63208459
3MP0001929_abnormal_gametogenesis4.19064271
4MP0003786_premature_aging4.05669376
5MP0010094_abnormal_chromosome_stability3.84692387
6MP0003122_maternal_imprinting3.78102440
7MP0001145_abnormal_male_reproductive3.72556557
8MP0008058_abnormal_DNA_repair3.67140914
9MP0003698_abnormal_male_reproductive3.57498635
10MP0005410_abnormal_fertilization3.54104889
11MP0000653_abnormal_sex_gland3.34947896
12MP0003880_abnormal_central_pattern3.29028649
13MP0003111_abnormal_nucleus_morphology3.12796325
14MP0003693_abnormal_embryo_hatching3.03073615
15MP0008057_abnormal_DNA_replication3.00983600
16MP0004859_abnormal_synaptic_plasticity2.99303339
17MP0004270_analgesia2.81449965
18MP0003123_paternal_imprinting2.77240159
19MP0002638_abnormal_pupillary_reflex2.68866122
20MP0004957_abnormal_blastocyst_morpholog2.60910696
21MP0003077_abnormal_cell_cycle2.49047086
22MP0001984_abnormal_olfaction2.46450538
23MP0000569_abnormal_digit_pigmentation2.30103236
24MP0002735_abnormal_chemical_nociception2.25452815
25MP0003011_delayed_dark_adaptation2.18216328
26MP0009046_muscle_twitch2.09468013
27MP0005084_abnormal_gallbladder_morpholo2.07942033
28MP0002161_abnormal_fertility/fecundity2.06803420
29MP0001486_abnormal_startle_reflex2.00502532
30MP0008877_abnormal_DNA_methylation10.2954862
31MP0003635_abnormal_synaptic_transmissio1.99254867
32MP0005551_abnormal_eye_electrophysiolog1.98334745
33MP0001968_abnormal_touch/_nociception1.96921923
34MP0008007_abnormal_cellular_replicative1.95166945
35MP0002822_catalepsy1.89804698
36MP0001986_abnormal_taste_sensitivity1.89518201
37MP0001529_abnormal_vocalization1.89512624
38MP0000778_abnormal_nervous_system1.89413101
39MP0001730_embryonic_growth_arrest1.82614153
40MP0002272_abnormal_nervous_system1.82253038
41MP0005423_abnormal_somatic_nervous1.81281892
42MP0002734_abnormal_mechanical_nocicepti1.77788741
43MP0002572_abnormal_emotion/affect_behav1.75993445
44MP0002063_abnormal_learning/memory/cond1.75820796
45MP0006072_abnormal_retinal_apoptosis1.75084618
46MP0002064_seizures1.70944634
47MP0009745_abnormal_behavioral_response1.69882885
48MP0004145_abnormal_muscle_electrophysio1.68674112
49MP0005253_abnormal_eye_physiology1.68631899
50MP0010307_abnormal_tumor_latency1.67616194
51MP0002928_abnormal_bile_duct1.67053651
52MP0002909_abnormal_adrenal_gland1.66400628
53MP0008932_abnormal_embryonic_tissue1.61959091
54MP0002736_abnormal_nociception_after1.60266037
55MP0001119_abnormal_female_reproductive1.58920039
56MP0005386_behavior/neurological_phenoty1.57588800
57MP0004924_abnormal_behavior1.57588800
58MP0002160_abnormal_reproductive_system1.57414909
59MP0006276_abnormal_autonomic_nervous1.56871248
60MP0005377_hearing/vestibular/ear_phenot1.54001308
61MP0003878_abnormal_ear_physiology1.54001308
62MP0010386_abnormal_urinary_bladder1.53662793
63MP0003195_calcinosis1.52995795
64MP0004133_heterotaxia1.47238119
65MP0002067_abnormal_sensory_capabilities1.44237356
66MP0002557_abnormal_social/conspecific_i1.43549612
67MP0000350_abnormal_cell_proliferation1.43289132
68MP0001501_abnormal_sleep_pattern1.39192909
69MP0005645_abnormal_hypothalamus_physiol1.36827985
70MP0002837_dystrophic_cardiac_calcinosis1.34898444
71MP0005379_endocrine/exocrine_gland_phen1.33809037
72MP0004142_abnormal_muscle_tone1.31382115
73MP0003121_genomic_imprinting1.29442236
74MP0005365_abnormal_bile_salt1.27852155
75MP0000955_abnormal_spinal_cord1.27801265
76MP0003890_abnormal_embryonic-extraembry1.25607272
77MP0002184_abnormal_innervation1.24820905
78MP0001970_abnormal_pain_threshold1.24488525
79MP0004808_abnormal_hematopoietic_stem1.23075260
80MP0005367_renal/urinary_system_phenotyp1.22550975
81MP0000516_abnormal_urinary_system1.22550975
82MP0004043_abnormal_pH_regulation1.21795667
83MP0004742_abnormal_vestibular_system1.21087485
84MP0002733_abnormal_thermal_nociception1.19619487
85MP0005085_abnormal_gallbladder_physiolo1.19425936
86MP0001299_abnormal_eye_distance/1.19019732
87MP0000631_abnormal_neuroendocrine_gland1.17796997
88MP0005380_embryogenesis_phenotype1.15831222
89MP0001672_abnormal_embryogenesis/_devel1.15831222
90MP0003315_abnormal_perineum_morphology1.13010704
91MP0004885_abnormal_endolymph1.10856983
92MP0003699_abnormal_female_reproductive1.10654900
93MP0002234_abnormal_pharynx_morphology1.07537805
94MP0002882_abnormal_neuron_morphology1.07053558
95MP0003718_maternal_effect1.06345386
96MP0003984_embryonic_growth_retardation1.05275095
97MP0002085_abnormal_embryonic_tissue1.04028578
98MP0005623_abnormal_meninges_morphology1.03973272
99MP0004197_abnormal_fetal_growth/weight/1.03701254
100MP0010352_gastrointestinal_tract_polyps1.03593212
101MP0005076_abnormal_cell_differentiation1.00740889
102MP0004215_abnormal_myocardial_fiber1.00390819
103MP0003633_abnormal_nervous_system1.00060213
104MP0001697_abnormal_embryo_size0.99865856
105MP0002090_abnormal_vision0.99535911
106MP0009672_abnormal_birth_weight0.98418970
107MP0002088_abnormal_embryonic_growth/wei0.98321470
108MP0005646_abnormal_pituitary_gland0.98153059
109MP0005670_abnormal_white_adipose0.96834800
110MP0002229_neurodegeneration0.96729419
111MP0005647_abnormal_sex_gland0.96064254
112MP0000313_abnormal_cell_death0.95034959
113MP0001661_extended_life_span0.95018136
114MP0002084_abnormal_developmental_patter0.93884586
115MP0002751_abnormal_autonomic_nervous0.93402044
116MP0001440_abnormal_grooming_behavior0.92891952
117MP0004811_abnormal_neuron_physiology0.92678160
118MP0002752_abnormal_somatic_nervous0.91999313
119MP0008569_lethality_at_weaning0.91701456
120MP0009780_abnormal_chondrocyte_physiolo0.91689082
121MP0002080_prenatal_lethality0.88814617
122MP0005083_abnormal_biliary_tract0.87243774
123MP0005389_reproductive_system_phenotype0.86918579
124MP0001502_abnormal_circadian_rhythm0.85939507
125MP0002152_abnormal_brain_morphology0.85162043
126MP0003936_abnormal_reproductive_system0.85028263
127MP0004085_abnormal_heartbeat0.84819082
128MP0003137_abnormal_impulse_conducting0.84159633
129MP0003183_abnormal_peptide_metabolism0.83311185
130MP0001485_abnormal_pinna_reflex0.83149403
131MP0002876_abnormal_thyroid_physiology0.82234395
132MP0005167_abnormal_blood-brain_barrier0.80668588
133MP0002066_abnormal_motor_capabilities/c0.78387177
134MP0002069_abnormal_eating/drinking_beha0.78313449
135MP0002163_abnormal_gland_morphology0.78093167
136MP0001727_abnormal_embryo_implantation0.77954537
137MP0001188_hyperpigmentation0.76697175
138MP0004484_altered_response_of0.73776533
139MP0002086_abnormal_extraembryonic_tissu0.73500003
140MP0000639_abnormal_adrenal_gland0.73429559
141MP0002019_abnormal_tumor_incidence0.72080817
142MP0003690_abnormal_glial_cell0.71883070
143MP0006054_spinal_hemorrhage0.71557187
144MP0003787_abnormal_imprinting0.69175648
145MP0006292_abnormal_olfactory_placode0.66325373
146MP0001293_anophthalmia0.66206158
147MP0003937_abnormal_limbs/digits/tail_de0.66117437
148MP0009703_decreased_birth_body0.65091431
149MP0000427_abnormal_hair_cycle0.65047582
150MP0002009_preneoplasia0.58215008
151MP0002653_abnormal_ependyma_morphology0.56530388
152MP0001915_intracranial_hemorrhage0.53359775
153MP0003221_abnormal_cardiomyocyte_apopto0.52889134
154MP0004233_abnormal_muscle_weight0.51931115
155MP0003115_abnormal_respiratory_system0.51507395
156MP0003119_abnormal_digestive_system0.51285286
157MP0005621_abnormal_cell_physiology0.49717039
158MP0003861_abnormal_nervous_system0.48183333
159MP0005666_abnormal_adipose_tissue0.47702359
160MP0004185_abnormal_adipocyte_glucose0.47585227
161MP0002102_abnormal_ear_morphology0.47140244
162MP0005384_cellular_phenotype0.46982919
163MP0003646_muscle_fatigue0.46249821
164MP0003941_abnormal_skin_development0.46218586
165MP0000647_abnormal_sebaceous_gland0.42408855
166MP0002697_abnormal_eye_size0.40110313
167MP0000383_abnormal_hair_follicle0.39634059
168MP0003705_abnormal_hypodermis_morpholog0.38812042
169MP0005395_other_phenotype0.38425162
170MP0003567_abnormal_fetal_cardiomyocyte0.37603889
171MP0002092_abnormal_eye_morphology0.37186352
172MP0002269_muscular_atrophy0.36612828
173MP0008260_abnormal_autophagy0.36475998
174MP0000432_abnormal_head_morphology0.36465934
175MP0003632_abnormal_nervous_system0.32227100
176MP0000358_abnormal_cell_content/0.30993388
177MP0000428_abnormal_craniofacial_morphol0.29039006
178MP0002970_abnormal_white_adipose0.26757085
179MP0002233_abnormal_nose_morphology0.26340562
180MP0000537_abnormal_urethra_morphology0.25889211
181MP0010678_abnormal_skin_adnexa0.25364104
182MP0003755_abnormal_palate_morphology0.24576247
183MP0005187_abnormal_penis_morphology0.24227304
184MP0005391_vision/eye_phenotype0.23142233
185MP0002396_abnormal_hematopoietic_system0.21994687
186MP0005397_hematopoietic_system_phenotyp0.21599493
187MP0001545_abnormal_hematopoietic_system0.21599493
188MP0000703_abnormal_thymus_morphology0.21136494

Predicted human phenotypes

RankGene SetZ-score
1* Azoospermia (HP:0000027)6.59793535
2* Abnormal spermatogenesis (HP:0008669)6.40695894
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.38347835
4Chromsome breakage (HP:0040012)5.08132609
5Abnormality of the lower motor neuron (HP:0002366)4.98999368
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.95311665
7Gonadotropin excess (HP:0000837)4.77476332
8Dynein arm defect of respiratory motile cilia (HP:0012255)4.72011732
9Absent/shortened dynein arms (HP:0200106)4.72011732
10Hyperventilation (HP:0002883)4.39211049
11Impulsivity (HP:0100710)4.05215528
12Febrile seizures (HP:0002373)3.83845219
13Focal motor seizures (HP:0011153)3.78993234
14Papillary thyroid carcinoma (HP:0002895)3.70548686
15Nephronophthisis (HP:0000090)3.65660757
16Carpal bone hypoplasia (HP:0001498)3.60999576
17Abnormal respiratory motile cilium physiology (HP:0012261)3.51206479
1811 pairs of ribs (HP:0000878)3.51162877
19Facial hemangioma (HP:0000329)3.49516244
20Birth length less than 3rd percentile (HP:0003561)3.49396212
21Ectopic kidney (HP:0000086)3.42509939
22Abnormal respiratory motile cilium morphology (HP:0005938)3.36838026
23Abnormal respiratory epithelium morphology (HP:0012253)3.36838026
24Pancreatic cysts (HP:0001737)3.34506077
25Chronic hepatic failure (HP:0100626)3.33478010
26Focal seizures (HP:0007359)3.32339904
27Abnormality of the labia minora (HP:0012880)3.31628135
28Drooling (HP:0002307)3.28966640
29True hermaphroditism (HP:0010459)3.22197604
30Abnormality of the anterior horn cell (HP:0006802)3.18440858
31Degeneration of anterior horn cells (HP:0002398)3.18440858
32Abnormality of the renal medulla (HP:0100957)3.08467509
33Pancreatic fibrosis (HP:0100732)3.07864391
34Duplicated collecting system (HP:0000081)3.07464783
35Abnormality of chromosome stability (HP:0003220)3.06649090
36Excessive salivation (HP:0003781)3.03398325
37Progressive cerebellar ataxia (HP:0002073)3.03196769
38Male infertility (HP:0003251)3.02129339
39Rhinitis (HP:0012384)2.98184405
40Amyotrophic lateral sclerosis (HP:0007354)2.98071003
41Absent thumb (HP:0009777)2.91544951
42Breast hypoplasia (HP:0003187)2.89879503
43Infertility (HP:0000789)2.88659408
44Absent speech (HP:0001344)2.88201522
45Abnormality of the renal cortex (HP:0011035)2.87779679
46Chronic bronchitis (HP:0004469)2.86552201
47Molar tooth sign on MRI (HP:0002419)2.86420977
48Abnormality of midbrain morphology (HP:0002418)2.86420977
49Capillary hemangiomas (HP:0005306)2.86076215
50Meckel diverticulum (HP:0002245)2.85924855
51Fibular hypoplasia (HP:0003038)2.84902228
52Intestinal atresia (HP:0011100)2.84395612
53Upper motor neuron abnormality (HP:0002127)2.83434423
54Genetic anticipation (HP:0003743)2.80250385
55Medial flaring of the eyebrow (HP:0010747)2.80145880
56Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.76908613
57Polyphagia (HP:0002591)2.76380177
58Lissencephaly (HP:0001339)2.76041810
59Abnormal hair whorl (HP:0010721)2.75997433
60Broad-based gait (HP:0002136)2.74218850
61Dialeptic seizures (HP:0011146)2.71854440
62Renal cortical cysts (HP:0000803)2.71523127
63Absent radius (HP:0003974)2.71001712
64Atonic seizures (HP:0010819)2.70066432
65Abnormality of the axillary hair (HP:0100134)2.65101847
66Abnormality of secondary sexual hair (HP:0009888)2.65101847
67Gait imbalance (HP:0002141)2.63924989
68Abnormal ciliary motility (HP:0012262)2.61398484
69Abnormality of the ileum (HP:0001549)2.60871303
70Nephrogenic diabetes insipidus (HP:0009806)2.58451337
71Spontaneous abortion (HP:0005268)2.56830581
72Absent forearm bone (HP:0003953)2.55516913
73Aplasia involving forearm bones (HP:0009822)2.55516913
74Gaze-evoked nystagmus (HP:0000640)2.53710107
75Shoulder girdle muscle weakness (HP:0003547)2.53390523
76Fair hair (HP:0002286)2.53385522
77Atrophy/Degeneration involving motor neurons (HP:0007373)2.52602627
78Supernumerary spleens (HP:0009799)2.46739885
79Aplasia/Hypoplasia of the uvula (HP:0010293)2.46372920
80Genital tract atresia (HP:0001827)2.46292927
81Hepatoblastoma (HP:0002884)2.45629708
82Congenital stationary night blindness (HP:0007642)2.43633639
83Epileptic encephalopathy (HP:0200134)2.42966808
84Abnormality of the renal collecting system (HP:0004742)2.42841862
85Tubulointerstitial nephritis (HP:0001970)2.41614867
86Metaphyseal cupping (HP:0003021)2.40683463
87Facial cleft (HP:0002006)2.40679051
88Thyroid carcinoma (HP:0002890)2.40620650
89Short thumb (HP:0009778)2.40123340
90Congenital primary aphakia (HP:0007707)2.38210165
91Hypothermia (HP:0002045)2.36852422
92Vaginal atresia (HP:0000148)2.36580650
93Protruding tongue (HP:0010808)2.36409529
94Bile duct proliferation (HP:0001408)2.35029457
95Abnormal biliary tract physiology (HP:0012439)2.35029457
96Medulloblastoma (HP:0002885)2.34505507
97Patellar aplasia (HP:0006443)2.34462959
98Hip dysplasia (HP:0001385)2.33722751
99Abnormality of the preputium (HP:0100587)2.32793133
100Broad alveolar ridges (HP:0000187)2.32726327
101Selective tooth agenesis (HP:0001592)2.31897151
102Hemiparesis (HP:0001269)2.30621340
103Ankle contracture (HP:0006466)2.30573323
104Colon cancer (HP:0003003)2.26081080
105Ureteral duplication (HP:0000073)2.25481649
106Shawl scrotum (HP:0000049)2.24381740
107Thyroid-stimulating hormone excess (HP:0002925)2.18610446
108Aplasia/Hypoplasia of the patella (HP:0006498)2.17209467
109Horseshoe kidney (HP:0000085)2.14713787
110Progressive inability to walk (HP:0002505)2.12563092
111Limb dystonia (HP:0002451)2.09867923
112Myokymia (HP:0002411)2.08847086
113Pachygyria (HP:0001302)2.08729259
114Long eyelashes (HP:0000527)2.08607590
115Oligodactyly (HP:0012165)2.07965233
116Aplasia/Hypoplasia of the fibula (HP:0006492)2.07402842
117Small intestinal stenosis (HP:0012848)2.07157626
118Duodenal stenosis (HP:0100867)2.07157626
119Sandal gap (HP:0001852)2.07145943
120Male pseudohermaphroditism (HP:0000037)2.06790641
121Inability to walk (HP:0002540)2.06177091
122Exotropia (HP:0000577)2.04956748
123Breast carcinoma (HP:0003002)2.04876704
124Short foot (HP:0001773)2.03767531
125Methylmalonic acidemia (HP:0002912)2.03389396
126Abnormality of the carotid arteries (HP:0005344)2.01748041
127Abnormality of homocysteine metabolism (HP:0010919)2.01220272
128Homocystinuria (HP:0002156)2.01220272
129Absence seizures (HP:0002121)2.00888876
130Short tibia (HP:0005736)2.00853283
131Heterotopia (HP:0002282)2.00093376
132Calf muscle hypertrophy (HP:0008981)1.98602788
133Abnormality of the corticospinal tract (HP:0002492)1.97604793
134Cystic liver disease (HP:0006706)1.97477868
135Abnormality of the ischium (HP:0003174)1.96269569
136Epileptiform EEG discharges (HP:0011182)1.96225331
137EEG with generalized epileptiform discharges (HP:0011198)1.95579429
138Aplasia/Hypoplasia of the earlobes (HP:0009906)1.95066322
139Hyperglycinemia (HP:0002154)1.94910050
140Spinal muscular atrophy (HP:0007269)1.94582463
141Postaxial hand polydactyly (HP:0001162)1.94559706
142Truncal obesity (HP:0001956)1.93646839
143Oligodactyly (hands) (HP:0001180)1.93603346
144Spastic tetraplegia (HP:0002510)1.92743211
145Hypsarrhythmia (HP:0002521)1.92476455
146Action tremor (HP:0002345)1.92173534
147Generalized tonic-clonic seizures (HP:0002069)1.91990924
148Prominent nose (HP:0000448)1.91664680
149Specific learning disability (HP:0001328)1.91614752
150Abnormal lung lobation (HP:0002101)1.91234228
151Pelvic girdle muscle weakness (HP:0003749)1.90858232
152Generalized hypopigmentation of hair (HP:0011358)1.90660613
153Widely spaced teeth (HP:0000687)1.90238007
154Neoplasm of the adrenal cortex (HP:0100641)1.89452170
155Abnormality of the astrocytes (HP:0100707)1.89083560
156Astrocytoma (HP:0009592)1.89083560
157Abnormality of the fingertips (HP:0001211)1.88461325
158Ependymoma (HP:0002888)1.88174635
159Narrow forehead (HP:0000341)1.88010849
160Impaired vibration sensation in the lower limbs (HP:0002166)1.87419806
161Epidermoid cyst (HP:0200040)1.86870027
162Microglossia (HP:0000171)1.86682715
163Increased nuchal translucency (HP:0010880)1.85720795
164Tubular atrophy (HP:0000092)1.85716519
165Aplasia/Hypoplasia of the tibia (HP:0005772)1.85246285
166Abnormality of the phalanges of the hallux (HP:0010057)1.85223522
167Missing ribs (HP:0000921)1.83978737
168Abnormal eating behavior (HP:0100738)1.83832787
169Cafe-au-lait spot (HP:0000957)1.83424006
170Papilledema (HP:0001085)1.82731244
171Hand muscle atrophy (HP:0009130)1.81139591
172Abnormality of the aortic arch (HP:0012303)1.80618871
173Hyperglycinuria (HP:0003108)1.80372755
174Abnormality of serine family amino acid metabolism (HP:0010894)1.79822657
175Abnormality of glycine metabolism (HP:0010895)1.79822657
176Tongue fasciculations (HP:0001308)1.78842742
177Abnormal biliary tract morphology (HP:0012440)1.78502577
178Optic nerve hypoplasia (HP:0000609)1.78221105
179Renovascular hypertension (HP:0100817)1.77216690
180Abnormality of DNA repair (HP:0003254)1.76864059
181Inappropriate behavior (HP:0000719)1.76425656
182Nephroblastoma (Wilms tumor) (HP:0002667)1.76374111
183Tented upper lip vermilion (HP:0010804)1.75736572
184Abnormality of the pubic bones (HP:0003172)1.74853999
185Absent eyebrow (HP:0002223)1.74629532
186Poor coordination (HP:0002370)1.74373488
187Aplasia/Hypoplasia involving the musculature (HP:0001460)1.74321782
188Rhabdomyosarcoma (HP:0002859)1.72430386
189Neonatal respiratory distress (HP:0002643)1.70639723
190Muscle hypertrophy of the lower extremities (HP:0008968)1.69273406
191Abnormality of salivation (HP:0100755)1.68864759

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.38401640
2CDK125.20752144
3ACVR1B5.06798696
4PDK34.26997693
5PDK44.26997693
6FRK4.14665671
7CASK3.62878145
8WEE13.36390617
9BRD42.74195180
10PDK22.64034764
11MAP4K22.63927905
12MAPK132.56278251
13NEK22.56139283
14PLK42.50082809
15BRSK22.18498578
16PLK12.04672352
17BUB12.01503254
18STK38L1.96664695
19CAMKK21.92458308
20SRPK11.92167002
21TTK1.85885468
22PAK31.84773577
23FGFR21.76247123
24MAP2K71.74809030
25NUAK11.71639453
26NTRK31.70569669
27CHEK11.61504728
28ATR1.58773976
29EPHA41.57651226
30GRK11.53127010
31CHEK21.51772960
32PRKD31.47746751
33MKNK21.42793244
34ERBB31.40261544
35FER1.37012973
36BRSK11.36101747
37TRIM281.36046326
38STK31.30998393
39NEK11.27321109
40CSNK1G21.25500387
41TNIK1.25060749
42UHMK11.24704636
43ATM1.24464756
44PLK31.23128164
45CDK71.22555147
46PBK1.19652579
47DYRK31.15073686
48MAP3K41.14198902
49PNCK1.13892269
50TESK11.12759899
51SGK21.12293188
52STK241.12115367
53NTRK21.10732888
54CSNK1A1L1.09798665
55DAPK21.06577899
56INSRR1.05382356
57PLK21.04983581
58CDK41.04298175
59PRKCE1.01652104
60CDK191.00151809
61SGK4940.98886770
62SGK2230.98886770
63OXSR10.97838587
64TNK20.95480268
65AURKB0.94711021
66MAP2K40.94130676
67DYRK1B0.93497344
68MKNK10.93155416
69TYRO30.92843949
70DYRK20.91484765
71CAMK1D0.90928281
72CDK20.90906162
73EIF2AK10.90843222
74CSNK1G10.90286495
75ZAK0.90278073
76SCYL20.89117115
77CAMK40.84266049
78TAOK30.84000585
79ICK0.83904695
80EPHA30.83614622
81CAMK10.80212633
82CDK10.80029758
83IRAK30.76892980
84PIK3CA0.76565113
85CDK50.75583610
86PRKCG0.75384602
87EPHA20.75189460
88LATS20.74883464
89MTOR0.74760165
90CAMKK10.74387283
91ADRBK20.74309786
92CSNK1G30.73795445
93STK40.72880222
94MELK0.72617376
95MINK10.68393742
96STK160.65156727
97PHKG10.65144128
98PHKG20.65144128
99IRAK10.64551738
100FGFR30.63735777
101CDK90.63663421
102NLK0.63418393
103MARK20.63074420
104STK110.61923578
105CAMK2A0.61446344
106PASK0.60519345
107PTK2B0.59768007
108PRKCZ0.59294595
109STK380.58535765
110PRKCH0.58288952
111TAF10.57946848
112WNK30.56680199
113CAMK2B0.55051758
114AURKA0.54692021
115TEC0.54318818
116OBSCN0.53652862
117MARK30.53477976
118CDC42BPA0.52711958
119PRKAA10.51544123
120PRKDC0.51219193
121VRK10.50967137
122CLK10.50524622
123PINK10.50439140
124PRKAA20.49762356
125CCNB10.49402435
126IRAK20.49113316
127SGK30.47509234
128PRKG10.46923168
129CSNK2A20.46613105
130PRKD20.44998653
131GSK3B0.44828871
132YES10.44646097
133CAMK1G0.44413112
134WNK10.44374822
135TSSK60.42946552
136CDK80.42344530
137EIF2AK30.42310989
138PRKCI0.41621771
139PRKACA0.40841913
140DYRK1A0.40468928
141CSNK1E0.40439328
142LATS10.39656860
143SGK10.39071067
144CAMK2D0.38422403
145RPS6KA30.37038640
146CSNK1D0.36332363
147ALK0.36081115
148GRK70.35655537
149SIK20.35567473
150PRKCQ0.35203759
151CSNK1A10.34425033
152CSNK2A10.34038657
153MAPK80.33984926
154TAOK10.33884017
155PKN10.33326758
156PRKCB0.33029543
157MAPK140.31600716
158TLK10.31424903
159MAP3K30.29655262
160LIMK10.28768409
161MAP3K90.27324063
162BCR0.24594060
163MAP3K80.24247151
164NME10.23222121
165WNK40.22420066
166MAPK100.22127150
167PAK10.22087529
168BMPR1B0.21837965
169MAP3K20.20491066
170BRAF0.19595027
171CDK30.19197083
172MARK10.19107411
173CHUK0.18760184
174AKT30.18154303
175STK390.17477258

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.64903558
2Basal transcription factors_Homo sapiens_hsa030224.73053558
3RNA polymerase_Homo sapiens_hsa030203.66208395
4RNA transport_Homo sapiens_hsa030133.54507617
5Homologous recombination_Homo sapiens_hsa034403.49743508
6DNA replication_Homo sapiens_hsa030303.35108656
7Mismatch repair_Homo sapiens_hsa034303.28858436
8Nicotine addiction_Homo sapiens_hsa050333.20101422
9Fanconi anemia pathway_Homo sapiens_hsa034603.15179148
10Cell cycle_Homo sapiens_hsa041103.04292366
11Proteasome_Homo sapiens_hsa030502.99324697
12Selenocompound metabolism_Homo sapiens_hsa004502.91995332
13mRNA surveillance pathway_Homo sapiens_hsa030152.89005776
14Spliceosome_Homo sapiens_hsa030402.76224982
15Vitamin B6 metabolism_Homo sapiens_hsa007502.75348389
16Nucleotide excision repair_Homo sapiens_hsa034202.62225650
17Phototransduction_Homo sapiens_hsa047442.28579345
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20213030
19GABAergic synapse_Homo sapiens_hsa047272.12128647
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07340520
21Base excision repair_Homo sapiens_hsa034102.07330528
22Oocyte meiosis_Homo sapiens_hsa041142.04274717
23Glutamatergic synapse_Homo sapiens_hsa047242.02530021
24Circadian entrainment_Homo sapiens_hsa047131.98412420
25Pyrimidine metabolism_Homo sapiens_hsa002401.96578962
26Morphine addiction_Homo sapiens_hsa050321.91138740
27Butanoate metabolism_Homo sapiens_hsa006501.86132938
28One carbon pool by folate_Homo sapiens_hsa006701.85906833
29Insulin secretion_Homo sapiens_hsa049111.78971633
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.77478276
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.76013953
32RNA degradation_Homo sapiens_hsa030181.74648189
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72380094
34Taste transduction_Homo sapiens_hsa047421.67662588
35Dopaminergic synapse_Homo sapiens_hsa047281.63960238
36Non-homologous end-joining_Homo sapiens_hsa034501.63427832
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.63226921
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.62761739
39Amphetamine addiction_Homo sapiens_hsa050311.52886577
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.52654673
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.51288734
42Tryptophan metabolism_Homo sapiens_hsa003801.50493726
43Purine metabolism_Homo sapiens_hsa002301.49207819
44Serotonergic synapse_Homo sapiens_hsa047261.44910024
45Dorso-ventral axis formation_Homo sapiens_hsa043201.44574554
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41333774
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37960632
48Histidine metabolism_Homo sapiens_hsa003401.35619754
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34739248
50p53 signaling pathway_Homo sapiens_hsa041151.32925909
51Cocaine addiction_Homo sapiens_hsa050301.32573760
52Cholinergic synapse_Homo sapiens_hsa047251.28526672
53Olfactory transduction_Homo sapiens_hsa047401.22099448
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21456623
55Renin secretion_Homo sapiens_hsa049241.21315739
56Pentose phosphate pathway_Homo sapiens_hsa000301.20367963
57Epstein-Barr virus infection_Homo sapiens_hsa051691.19974803
58Salivary secretion_Homo sapiens_hsa049701.19018673
59Calcium signaling pathway_Homo sapiens_hsa040201.17216827
60Long-term depression_Homo sapiens_hsa047301.16234720
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14607570
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10830958
63beta-Alanine metabolism_Homo sapiens_hsa004101.08018959
64Gastric acid secretion_Homo sapiens_hsa049711.04949863
65Herpes simplex infection_Homo sapiens_hsa051681.03279261
66Synaptic vesicle cycle_Homo sapiens_hsa047211.02757705
67ABC transporters_Homo sapiens_hsa020101.00357008
68Long-term potentiation_Homo sapiens_hsa047201.00321387
69Retinol metabolism_Homo sapiens_hsa008300.97857206
70Oxytocin signaling pathway_Homo sapiens_hsa049210.97735941
71Lysine degradation_Homo sapiens_hsa003100.95633187
72Peroxisome_Homo sapiens_hsa041460.95618085
73Axon guidance_Homo sapiens_hsa043600.94699582
74Huntingtons disease_Homo sapiens_hsa050160.93369287
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92375594
76cAMP signaling pathway_Homo sapiens_hsa040240.92070479
77Ovarian steroidogenesis_Homo sapiens_hsa049130.91452230
78Nitrogen metabolism_Homo sapiens_hsa009100.89436655
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89318435
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88116488
81Fatty acid degradation_Homo sapiens_hsa000710.87706370
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87221547
83Thyroid cancer_Homo sapiens_hsa052160.85764591
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.84815475
85Glycerolipid metabolism_Homo sapiens_hsa005610.82950941
86Chemical carcinogenesis_Homo sapiens_hsa052040.81200225
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.79800210
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77950999
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76809432
90Protein export_Homo sapiens_hsa030600.76246377
91Collecting duct acid secretion_Homo sapiens_hsa049660.74442269
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70491368
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.70168900
94Caffeine metabolism_Homo sapiens_hsa002320.69530948
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69112848
96Pancreatic secretion_Homo sapiens_hsa049720.66878834
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66314503
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.64389762
99Viral carcinogenesis_Homo sapiens_hsa052030.62738733
100Linoleic acid metabolism_Homo sapiens_hsa005910.61632306
101Bile secretion_Homo sapiens_hsa049760.59043573
102Ras signaling pathway_Homo sapiens_hsa040140.58335264
103HTLV-I infection_Homo sapiens_hsa051660.57270199
104Biosynthesis of amino acids_Homo sapiens_hsa012300.54846724
105Type II diabetes mellitus_Homo sapiens_hsa049300.54401820
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53412822
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52527256
108TGF-beta signaling pathway_Homo sapiens_hsa043500.51796596
109Fatty acid biosynthesis_Homo sapiens_hsa000610.49464363
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48146837
111Thyroid hormone synthesis_Homo sapiens_hsa049180.47174481
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46947392
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45586288
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45563218
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44388114
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43771647
117Pyruvate metabolism_Homo sapiens_hsa006200.43410274
118MicroRNAs in cancer_Homo sapiens_hsa052060.43144233
119Antigen processing and presentation_Homo sapiens_hsa046120.42699474
120Influenza A_Homo sapiens_hsa051640.41959879
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41539200
122Systemic lupus erythematosus_Homo sapiens_hsa053220.41446664
123Tight junction_Homo sapiens_hsa045300.40893386
124Cardiac muscle contraction_Homo sapiens_hsa042600.40069105
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39990258
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39017528
127Vitamin digestion and absorption_Homo sapiens_hsa049770.38890700
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36592190
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36530558
130Glucagon signaling pathway_Homo sapiens_hsa049220.33609806
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33500628
132Hippo signaling pathway_Homo sapiens_hsa043900.31900290
133Adherens junction_Homo sapiens_hsa045200.29605772
134Regulation of autophagy_Homo sapiens_hsa041400.27571504
135FoxO signaling pathway_Homo sapiens_hsa040680.26857423
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26652118
137Glutathione metabolism_Homo sapiens_hsa004800.26151071
138Mineral absorption_Homo sapiens_hsa049780.25885719
139Ether lipid metabolism_Homo sapiens_hsa005650.23991833
140Fat digestion and absorption_Homo sapiens_hsa049750.23386090
141Folate biosynthesis_Homo sapiens_hsa007900.20900519
142Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.18994154
143Carbon metabolism_Homo sapiens_hsa012000.17062634
144Metabolic pathways_Homo sapiens_hsa011000.16988348
145Propanoate metabolism_Homo sapiens_hsa006400.16842598
146Notch signaling pathway_Homo sapiens_hsa043300.16508716
147Small cell lung cancer_Homo sapiens_hsa052220.15996672
148Inositol phosphate metabolism_Homo sapiens_hsa005620.15171565
149Hedgehog signaling pathway_Homo sapiens_hsa043400.12361799
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11627388
151Drug metabolism - other enzymes_Homo sapiens_hsa009830.11098628
152Prostate cancer_Homo sapiens_hsa052150.10966941
153Ribosome_Homo sapiens_hsa030100.07811788
154Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.07485008
155Glycosaminoglycan degradation_Homo sapiens_hsa005310.05382653
156Wnt signaling pathway_Homo sapiens_hsa043100.05346025
157Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.04084702
158Renal cell carcinoma_Homo sapiens_hsa052110.03732386
159Phosphatidylinositol signaling system_Homo sapiens_hsa040700.03671414
160Fatty acid metabolism_Homo sapiens_hsa012120.02653133
161Pathways in cancer_Homo sapiens_hsa052000.02569157
162Circadian rhythm_Homo sapiens_hsa047100.02223233
163Steroid biosynthesis_Homo sapiens_hsa001000.02068556
164Steroid hormone biosynthesis_Homo sapiens_hsa001400.01539956
165AMPK signaling pathway_Homo sapiens_hsa041520.01331784
166Transcriptional misregulation in cancer_Homo sapiens_hsa052020.00710346
167Arachidonic acid metabolism_Homo sapiens_hsa005900.00631759
168HIF-1 signaling pathway_Homo sapiens_hsa040660.00391441
169Alcoholism_Homo sapiens_hsa05034-0.0337286
170Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0083294

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »