ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.50722057
2	response to pheromone (GO:0019236)	5.13406648
3	L-fucose catabolic process (GO:0042355)	5.08501898
4	fucose catabolic process (GO:0019317)	5.08501898
5	L-fucose metabolic process (GO:0042354)	5.08501898
6	cellular ketone body metabolic process (GO:0046950)	4.28352283
7	DNA deamination (GO:0045006)	4.22139950
8	protein polyglutamylation (GO:0018095)	4.18501725
9	ketone body metabolic process (GO:1902224)	3.89540345
10	water-soluble vitamin biosynthetic process (GO:0042364)	3.81928055
11	negative regulation of telomere maintenance (GO:0032205)	3.70953715
12	detection of light stimulus involved in sensory perception (GO:0050962)	3.38024169
13	detection of light stimulus involved in visual perception (GO:0050908)	3.38024169
14	protein K11-linked deubiquitination (GO:0035871)	3.34791130
15	platelet dense granule organization (GO:0060155)	3.34595699
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.30579533
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.30579533
18	NADH dehydrogenase complex assembly (GO:0010257)	3.30579533
19	respiratory chain complex IV assembly (GO:0008535)	3.28055689
20	preassembly of GPI anchor in ER membrane (GO:0016254)	3.24320624
21	ubiquinone biosynthetic process (GO:0006744)	3.21581281
22	protein complex biogenesis (GO:0070271)	3.19633612
23	piRNA metabolic process (GO:0034587)	3.18741497
24	protein localization to cilium (GO:0061512)	3.17712779
25	nonmotile primary cilium assembly (GO:0035058)	3.16056168
26	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.15901015
27	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.14541576
28	axoneme assembly (GO:0035082)	3.14539189
29	tryptophan catabolic process (GO:0006569)	3.13966668
30	indole-containing compound catabolic process (GO:0042436)	3.13966668
31	indolalkylamine catabolic process (GO:0046218)	3.13966668
32	mitochondrial respiratory chain complex assembly (GO:0033108)	3.11561184
33	ubiquinone metabolic process (GO:0006743)	3.05634619
34	indolalkylamine metabolic process (GO:0006586)	3.05066094
35	synaptic transmission, cholinergic (GO:0007271)	2.98582549
36	regulation of action potential (GO:0098900)	2.97646417
37	pyrimidine nucleobase catabolic process (GO:0006208)	2.95585598
38	protein-cofactor linkage (GO:0018065)	2.93510838
39	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.91009153
40	retinal cone cell development (GO:0046549)	2.89545765
41	regulation of glucokinase activity (GO:0033131)	2.87879060
42	regulation of hexokinase activity (GO:1903299)	2.87879060
43	reflex (GO:0060004)	2.87697134
44	epithelial cilium movement (GO:0003351)	2.86345252
45	inositol phosphate catabolic process (GO:0071545)	2.85887071
46	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.83693957
47	proline transport (GO:0015824)	2.81927624
48	dopamine transport (GO:0015872)	2.81254197
49	positive regulation of mitochondrial fission (GO:0090141)	2.81056190
50	primary amino compound metabolic process (GO:1901160)	2.78905820
51	behavioral response to ethanol (GO:0048149)	2.77723801
52	gamma-aminobutyric acid transport (GO:0015812)	2.76688521
53	kynurenine metabolic process (GO:0070189)	2.76512927
54	nucleobase catabolic process (GO:0046113)	2.75380202
55	polyol catabolic process (GO:0046174)	2.73664251
56	indole-containing compound metabolic process (GO:0042430)	2.73430483
57	rRNA catabolic process (GO:0016075)	2.73369242
58	C-terminal protein amino acid modification (GO:0018410)	2.71415570
59	peptidyl-histidine modification (GO:0018202)	2.71238057
60	DNA methylation involved in gamete generation (GO:0043046)	2.69804065
61	negative regulation of heart rate (GO:0010459)	2.66974159
62	cytochrome complex assembly (GO:0017004)	2.66682434
63	DNA double-strand break processing (GO:0000729)	2.66250538
64	mannosylation (GO:0097502)	2.66226446
65	tryptophan metabolic process (GO:0006568)	2.66134669
66	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.65967345
67	cornea development in camera-type eye (GO:0061303)	2.65192133
68	neural tube formation (GO:0001841)	2.63828874
69	sulfation (GO:0051923)	2.63555010
70	synapsis (GO:0007129)	2.63457478
71	replication fork processing (GO:0031297)	2.63306582
72	cAMP catabolic process (GO:0006198)	2.61118507
73	GPI anchor metabolic process (GO:0006505)	2.60381668
74	cilium morphogenesis (GO:0060271)	2.60267997
75	glycerophospholipid catabolic process (GO:0046475)	2.59611233
76	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.59238540
77	regulation of memory T cell differentiation (GO:0043380)	2.58443763
78	serotonin metabolic process (GO:0042428)	2.56981253
79	quinone biosynthetic process (GO:1901663)	2.55011154
80	regulation of cilium movement (GO:0003352)	2.53926608
81	alanine transport (GO:0032328)	2.53517079
82	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.52307817
83	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.52140909
84	protein K6-linked ubiquitination (GO:0085020)	2.51836334
85	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.51201165
86	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.50086198
87	photoreceptor cell maintenance (GO:0045494)	2.49501544
88	intraciliary transport (GO:0042073)	2.49064086
89	neuronal action potential (GO:0019228)	2.48854647
90	fucosylation (GO:0036065)	2.47314721
91	spinal cord motor neuron differentiation (GO:0021522)	2.46415853
92	nephron tubule morphogenesis (GO:0072078)	2.46022202
93	nephron epithelium morphogenesis (GO:0072088)	2.46022202
94	neuronal action potential propagation (GO:0019227)	2.45800780
95	cilium organization (GO:0044782)	2.45253907
96	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.44874059
97	inositol phosphate dephosphorylation (GO:0046855)	2.44874059
98	adaptation of signaling pathway (GO:0023058)	2.44567452
99	negative regulation of mast cell activation (GO:0033004)	2.43991418
100	C-terminal protein lipidation (GO:0006501)	2.43112378

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.26247315
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.36557252
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.35309757
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.17418714
5	VDR_22108803_ChIP-Seq_LS180_Human	3.07755851
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.62007432
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.47525065
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.32235596
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27207059
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.22037205
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.18317312
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16935622
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.16069488
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.04183927
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.01702813
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.99713118
17	FUS_26573619_Chip-Seq_HEK293_Human	1.92322219
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.92077447
19	P300_19829295_ChIP-Seq_ESCs_Human	1.91078710
20	EWS_26573619_Chip-Seq_HEK293_Human	1.89194215
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.87889866
22	TP53_22573176_ChIP-Seq_HFKS_Human	1.74163588
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.65617572
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64908319
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.58330561
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57693998
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.57169362
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.54440014
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.54190019
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.53229741
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52639716
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49068897
33	AR_25329375_ChIP-Seq_VCAP_Human	1.47369047
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.46742761
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46742761
36	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.44656213
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.44364090
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.43568239
39	REST_21632747_ChIP-Seq_MESCs_Mouse	1.38836506
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38511334
41	STAT3_23295773_ChIP-Seq_U87_Human	1.37961908
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36768378
43	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36768378
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36451003
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.35567013
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32754234
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.32745258
48	TCF4_23295773_ChIP-Seq_U87_Human	1.29563466
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28373131
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28373131
51	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.28303566
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28244848
53	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.28157626
54	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.27296698
55	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.27114264
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27067077
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26999706
58	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.26579454
59	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.24981576
60	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24395044
61	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23498090
62	NCOR_22424771_ChIP-Seq_293T_Human	1.23170900
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.20382216
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20323934
65	VDR_23849224_ChIP-Seq_CD4+_Human	1.20286143
66	HOXB7_26014856_ChIP-Seq_BT474_Human	1.19465417
67	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19055437
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18963036
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18833780
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18560043
71	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18152727
72	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17892138
73	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.17892138
74	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17794779
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16062254
76	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.14386981
77	AR_21572438_ChIP-Seq_LNCaP_Human	1.13955138
78	AR_20517297_ChIP-Seq_VCAP_Human	1.13368367
79	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12810032
80	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12696172
81	HTT_18923047_ChIP-ChIP_STHdh_Human	1.11514035
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05157302
83	ELK1_19687146_ChIP-ChIP_HELA_Human	1.05025005
84	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04111164
85	ERA_21632823_ChIP-Seq_H3396_Human	1.03706740
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03446028
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02695278
88	RNF2_27304074_Chip-Seq_NSC_Mouse	1.01903841
89	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01626616
90	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.01574793
91	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01408092
92	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01128612
93	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.98560024
94	JUN_21703547_ChIP-Seq_K562_Human	0.98178632
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.97732780
96	P53_22387025_ChIP-Seq_ESCs_Mouse	0.97635166
97	CDX2_22108803_ChIP-Seq_LS180_Human	0.97041324
98	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96973569
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96773933
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.94394335

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.27859845
2	MP0008877_abnormal_DNA_methylation	3.14619168
3	MP0002102_abnormal_ear_morphology	2.72609853
4	MP0003880_abnormal_central_pattern	2.43442399
5	MP0000569_abnormal_digit_pigmentation	2.39859534
6	MP0005551_abnormal_eye_electrophysiolog	2.31243879
7	MP0006276_abnormal_autonomic_nervous	2.24289022
8	MP0003011_delayed_dark_adaptation	2.22312200
9	MP0006072_abnormal_retinal_apoptosis	2.14751827
10	MP0005645_abnormal_hypothalamus_physiol	2.14527802
11	MP0004885_abnormal_endolymph	2.12552343
12	MP0004147_increased_porphyrin_level	2.09255668
13	MP0009046_muscle_twitch	2.07792446
14	MP0009745_abnormal_behavioral_response	2.03541863
15	MP0001529_abnormal_vocalization	2.01423731
16	MP0003787_abnormal_imprinting	2.00599659
17	MP0004133_heterotaxia	1.93465802
18	MP0004043_abnormal_pH_regulation	1.92870326
19	MP0002638_abnormal_pupillary_reflex	1.92190902
20	MP0005253_abnormal_eye_physiology	1.90620021
21	MP0005084_abnormal_gallbladder_morpholo	1.88910524
22	MP0000372_irregular_coat_pigmentation	1.87202262
23	MP0000427_abnormal_hair_cycle	1.83806658
24	MP0002837_dystrophic_cardiac_calcinosis	1.82403085
25	MP0002876_abnormal_thyroid_physiology	1.76608453
26	MP0008872_abnormal_physiological_respon	1.75822074
27	MP0001968_abnormal_touch/_nociception	1.74594602
28	MP0004142_abnormal_muscle_tone	1.74261335
29	MP0003136_yellow_coat_color	1.67273982
30	MP0002736_abnormal_nociception_after	1.61940647
31	MP0001984_abnormal_olfaction	1.60960970
32	MP0008875_abnormal_xenobiotic_pharmacok	1.58881723
33	MP0002272_abnormal_nervous_system	1.57573102
34	MP0002653_abnormal_ependyma_morphology	1.57155824
35	MP0002572_abnormal_emotion/affect_behav	1.54162134
36	MP0001986_abnormal_taste_sensitivity	1.49121413
37	MP0003122_maternal_imprinting	1.48271651
38	MP0002064_seizures	1.47117410
39	MP0005646_abnormal_pituitary_gland	1.44456959
40	MP0003646_muscle_fatigue	1.41618300
41	MP0001501_abnormal_sleep_pattern	1.37835199
42	MP0002138_abnormal_hepatobiliary_system	1.37456521
43	MP0008995_early_reproductive_senescence	1.36655699
44	MP0001905_abnormal_dopamine_level	1.35918948
45	MP0002277_abnormal_respiratory_mucosa	1.30786385
46	MP0002928_abnormal_bile_duct	1.29938770
47	MP0000631_abnormal_neuroendocrine_gland	1.29321248
48	MP0005075_abnormal_melanosome_morpholog	1.26891557
49	MP0002557_abnormal_social/conspecific_i	1.23951023
50	MP0004742_abnormal_vestibular_system	1.22354938
51	MP0002063_abnormal_learning/memory/cond	1.20817309
52	MP0003635_abnormal_synaptic_transmissio	1.20615203
53	MP0004270_analgesia	1.18869186
54	MP0005167_abnormal_blood-brain_barrier	1.18821642
55	MP0001486_abnormal_startle_reflex	1.18452083
56	MP0001485_abnormal_pinna_reflex	1.16330640
57	MP0000647_abnormal_sebaceous_gland	1.15226354
58	MP0003121_genomic_imprinting	1.15153901
59	MP0005379_endocrine/exocrine_gland_phen	1.14670014
60	MP0005085_abnormal_gallbladder_physiolo	1.13073479
61	MP0003283_abnormal_digestive_organ	1.12227574
62	MP0002751_abnormal_autonomic_nervous	1.10820867
63	MP0001970_abnormal_pain_threshold	1.10435207
64	MP0002234_abnormal_pharynx_morphology	1.10314219
65	MP0002909_abnormal_adrenal_gland	1.09559335
66	MP0010386_abnormal_urinary_bladder	1.09429741
67	MP0005389_reproductive_system_phenotype	1.07477070
68	MP0002735_abnormal_chemical_nociception	1.07301714
69	MP0005332_abnormal_amino_acid	1.04935143
70	MP0002734_abnormal_mechanical_nocicepti	1.03976558
71	MP0005365_abnormal_bile_salt	1.03639795
72	MP0005386_behavior/neurological_phenoty	1.03571675
73	MP0004924_abnormal_behavior	1.03571675
74	MP0004145_abnormal_muscle_electrophysio	1.03332875
75	MP0002067_abnormal_sensory_capabilities	1.02985042
76	MP0001764_abnormal_homeostasis	0.99834192
77	MP0002254_reproductive_system_inflammat	0.99821347
78	MP0002160_abnormal_reproductive_system	0.98561403
79	MP0002163_abnormal_gland_morphology	0.98520527
80	MP0001502_abnormal_circadian_rhythm	0.97679791
81	MP0000230_abnormal_systemic_arterial	0.95914387
82	MP0005423_abnormal_somatic_nervous	0.95428005
83	MP0006292_abnormal_olfactory_placode	0.95421514
84	MP0006035_abnormal_mitochondrial_morpho	0.93973967
85	MP0002095_abnormal_skin_pigmentation	0.93914167
86	MP0002938_white_spotting	0.92926958
87	MP0003890_abnormal_embryonic-extraembry	0.90307578
88	MP0002733_abnormal_thermal_nociception	0.89715381
89	MP0000778_abnormal_nervous_system	0.89290675
90	MP0001919_abnormal_reproductive_system	0.89224893
91	MP0000015_abnormal_ear_pigmentation	0.88407365
92	MP0002229_neurodegeneration	0.88385318
93	MP0005195_abnormal_posterior_eye	0.87854306
94	MP0005410_abnormal_fertilization	0.87373292
95	MP0002752_abnormal_somatic_nervous	0.85880278
96	MP0002184_abnormal_innervation	0.84793997
97	MP0008058_abnormal_DNA_repair	0.84533835
98	MP0009780_abnormal_chondrocyte_physiolo	0.83958547
99	MP0003718_maternal_effect	0.81772150
100	MP0008775_abnormal_heart_ventricle	0.81690058

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Molar tooth sign on MRI (HP:0002419)	4.24867951
2	Abnormality of midbrain morphology (HP:0002418)	4.24867951
3	Pancreatic cysts (HP:0001737)	4.09373421
4	Pancreatic fibrosis (HP:0100732)	3.75373917
5	True hermaphroditism (HP:0010459)	3.67543671
6	Abnormality of alanine metabolism (HP:0010916)	3.55411386
7	Hyperalaninemia (HP:0003348)	3.55411386
8	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.55411386
9	Congenital stationary night blindness (HP:0007642)	3.32380075
10	Nephronophthisis (HP:0000090)	3.25963650
11	Methylmalonic acidemia (HP:0002912)	3.18624031
12	Type II lissencephaly (HP:0007260)	3.17761912
13	Medial flaring of the eyebrow (HP:0010747)	3.07810655
14	Progressive inability to walk (HP:0002505)	3.04796992
15	Inability to walk (HP:0002540)	3.03057351
16	Abnormality of the renal cortex (HP:0011035)	3.00234149
17	Gait imbalance (HP:0002141)	2.85033529
18	Abnormality of the renal medulla (HP:0100957)	2.84439043
19	Chronic hepatic failure (HP:0100626)	2.82370197
20	Nephrogenic diabetes insipidus (HP:0009806)	2.75123909
21	Methylmalonic aciduria (HP:0012120)	2.74385074
22	Congenital primary aphakia (HP:0007707)	2.70238119
23	Attenuation of retinal blood vessels (HP:0007843)	2.62299256
24	Abolished electroretinogram (ERG) (HP:0000550)	2.55242529
25	Lissencephaly (HP:0001339)	2.53280687
26	Cystic liver disease (HP:0006706)	2.51475158
27	Acute necrotizing encephalopathy (HP:0006965)	2.50000026
28	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.45659646
29	Absent/shortened dynein arms (HP:0200106)	2.45659646
30	Large for gestational age (HP:0001520)	2.43938028
31	Polydipsia (HP:0001959)	2.43847946
32	Abnormal drinking behavior (HP:0030082)	2.43847946
33	Hypomagnesemia (HP:0002917)	2.37157935
34	Tubular atrophy (HP:0000092)	2.35447402
35	Acute encephalopathy (HP:0006846)	2.32746731
36	Ketoacidosis (HP:0001993)	2.29819512
37	Limb dystonia (HP:0002451)	2.29179256
38	Pendular nystagmus (HP:0012043)	2.28485433
39	Renal cortical cysts (HP:0000803)	2.28273310
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.26485142
41	Hyperventilation (HP:0002883)	2.24444545
42	Abnormality of vitamin B metabolism (HP:0004340)	2.22946230
43	Mitochondrial inheritance (HP:0001427)	2.20792753
44	Polyuria (HP:0000103)	2.20471911
45	Abnormal biliary tract physiology (HP:0012439)	2.19261190
46	Bile duct proliferation (HP:0001408)	2.19261190
47	Severe muscular hypotonia (HP:0006829)	2.18522966
48	Increased CSF lactate (HP:0002490)	2.18172192
49	Gaze-evoked nystagmus (HP:0000640)	2.16088394
50	Abnormality of the labia minora (HP:0012880)	2.13282654
51	Progressive macrocephaly (HP:0004481)	2.11685773
52	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.10846080
53	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.10028446
54	Genital tract atresia (HP:0001827)	2.09914523
55	Decreased central vision (HP:0007663)	2.09299161
56	Progressive cerebellar ataxia (HP:0002073)	2.09213750
57	Cerebellar dysplasia (HP:0007033)	2.08664156
58	Abnormal mitochondria in muscle tissue (HP:0008316)	2.06679580
59	Focal motor seizures (HP:0011153)	2.04322882
60	Pachygyria (HP:0001302)	2.04255595
61	Retinal dysplasia (HP:0007973)	2.04049255
62	Poor coordination (HP:0002370)	2.03976233
63	Tachypnea (HP:0002789)	2.03951097
64	Vaginal atresia (HP:0000148)	2.03503851
65	Hypothermia (HP:0002045)	2.03315891
66	Broad-based gait (HP:0002136)	2.03128805
67	Concave nail (HP:0001598)	2.02071988
68	Polyphagia (HP:0002591)	2.01876230
69	Sclerocornea (HP:0000647)	2.01806365
70	Ketosis (HP:0001946)	2.01666409
71	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.00753519
72	3-Methylglutaconic aciduria (HP:0003535)	2.00168582
73	Furrowed tongue (HP:0000221)	1.98416537
74	Hyperglycinemia (HP:0002154)	1.95871078
75	Keratoconus (HP:0000563)	1.94185368
76	Increased corneal curvature (HP:0100692)	1.94185368
77	Febrile seizures (HP:0002373)	1.94038878
78	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.93194286
79	Male pseudohermaphroditism (HP:0000037)	1.91764858
80	Lipid accumulation in hepatocytes (HP:0006561)	1.91439828
81	Disproportionate short-trunk short stature (HP:0003521)	1.88946822
82	Anencephaly (HP:0002323)	1.87611935
83	Optic disc pallor (HP:0000543)	1.86671587
84	Type 2 muscle fiber atrophy (HP:0003554)	1.84593023
85	Bony spicule pigmentary retinopathy (HP:0007737)	1.83463495
86	Congenital, generalized hypertrichosis (HP:0004540)	1.83067344
87	Abnormal respiratory epithelium morphology (HP:0012253)	1.80817658
88	Abnormal respiratory motile cilium morphology (HP:0005938)	1.80817658
89	Increased serum lactate (HP:0002151)	1.80442510
90	Occipital encephalocele (HP:0002085)	1.79812414
91	Widely spaced teeth (HP:0000687)	1.75684204
92	Drooling (HP:0002307)	1.74592185
93	Short tibia (HP:0005736)	1.74469793
94	Abnormality of serum amino acid levels (HP:0003112)	1.73655691
95	Increased hepatocellular lipid droplets (HP:0006565)	1.73300763
96	Morphological abnormality of the pyramidal tract (HP:0002062)	1.72877333
97	Abnormal urine output (HP:0012590)	1.72730727
98	Postaxial foot polydactyly (HP:0001830)	1.71261711
99	Congenital hepatic fibrosis (HP:0002612)	1.70743699
100	Chorioretinal atrophy (HP:0000533)	1.69327350

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.78593484
2	WNK3	3.43352111
3	MAP4K2	3.22586269
4	ADRBK2	3.17538995
5	PINK1	3.05963398
6	WNK4	2.71614732
7	NUAK1	2.69508929
8	ZAK	2.45354957
9	TLK1	2.31961368
10	GRK1	2.24226212
11	MAP3K4	2.18017949
12	OXSR1	2.06142763
13	BMPR1B	2.02710042
14	MAPK13	1.95179535
15	TRIM28	1.94465734
16	TAOK3	1.91592406
17	CASK	1.75632545
18	DAPK2	1.74937878
19	MUSK	1.72012102
20	STK39	1.68184462
21	BCKDK	1.56301105
22	MAPKAPK3	1.55755106
23	CSNK1G2	1.50886266
24	CSNK1G3	1.50816857
25	CSNK1G1	1.44213895
26	PNCK	1.43873720
27	MARK1	1.43720517
28	MAP2K7	1.43445515
29	ACVR1B	1.34180458
30	CAMKK2	1.27773025
31	TXK	1.26017285
32	BCR	1.22035403
33	DYRK2	1.20266721
34	CSNK1A1L	1.16864911
35	PAK3	1.16168997
36	ADRBK1	1.05014802
37	TSSK6	1.04856978
38	STK38L	1.04650409
39	PHKG2	1.02756569
40	PHKG1	1.02756569
41	INSRR	0.93016542
42	EPHA4	0.90552901
43	PRKCG	0.86302890
44	SIK2	0.85255849
45	PRKCE	0.84690561
46	ERBB3	0.79260116
47	TIE1	0.77320077
48	VRK1	0.75470932
49	MKNK2	0.73580189
50	NME1	0.72434059
51	FER	0.72090375
52	MAPKAPK5	0.70908892
53	NTRK3	0.69806713
54	MATK	0.64792398
55	PTK2B	0.63875481
56	MAP2K6	0.59958109
57	LIMK1	0.59685533
58	PRKCQ	0.59596680
59	NLK	0.59303362
60	MKNK1	0.58281394
61	RPS6KA5	0.57653360
62	GRK7	0.57324405
63	CAMK2A	0.54376332
64	NTRK2	0.53578609
65	PASK	0.53433532
66	TGFBR1	0.52777947
67	CDK3	0.50748330
68	EPHA3	0.50389071
69	MINK1	0.49672139
70	RPS6KA4	0.48772271
71	MAP2K4	0.48552206
72	PLK2	0.48543694
73	TNIK	0.48369109
74	CDK19	0.48257512
75	TEC	0.47641929
76	PIK3CA	0.45851793
77	CSNK1A1	0.43439977
78	MAPK15	0.42979756
79	PLK3	0.41943189
80	MST4	0.41817898
81	CAMK1	0.41613870
82	STK11	0.39803182
83	GRK5	0.39225940
84	TNK2	0.38299665
85	PRKACA	0.38017785
86	FES	0.36048015
87	PKN1	0.35475635
88	IKBKB	0.35446356
89	ATR	0.33294894
90	WEE1	0.33033143
91	PRKAA1	0.31979025
92	VRK2	0.31765231
93	FLT3	0.30623804
94	PRKCH	0.30292695
95	CSNK1D	0.30230288
96	DAPK1	0.29787071
97	ITK	0.29624815
98	PRKG1	0.27873890
99	IRAK1	0.27345910
100	CAMK2D	0.26667101

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.90941279
2	Selenocompound metabolism_Homo sapiens_hsa00450	2.85390509
3	Butanoate metabolism_Homo sapiens_hsa00650	2.77365854
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.74487209
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.48690857
6	Phototransduction_Homo sapiens_hsa04744	2.48665020
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.44795851
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.32260544
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.30447805
10	Nicotine addiction_Homo sapiens_hsa05033	2.27756210
11	Protein export_Homo sapiens_hsa03060	2.26896440
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.18873375
13	Nitrogen metabolism_Homo sapiens_hsa00910	2.17837864
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.17255947
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.89068461
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.87228607
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.81365681
18	Parkinsons disease_Homo sapiens_hsa05012	1.76257586
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.74521066
20	Basal transcription factors_Homo sapiens_hsa03022	1.67857959
21	Propanoate metabolism_Homo sapiens_hsa00640	1.63003435
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.62558236
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.60725333
24	Caffeine metabolism_Homo sapiens_hsa00232	1.57322516
25	Olfactory transduction_Homo sapiens_hsa04740	1.43001294
26	Homologous recombination_Homo sapiens_hsa03440	1.40198309
27	Taste transduction_Homo sapiens_hsa04742	1.39132184
28	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.38194197
29	RNA degradation_Homo sapiens_hsa03018	1.33943230
30	RNA polymerase_Homo sapiens_hsa03020	1.33597515
31	Peroxisome_Homo sapiens_hsa04146	1.33260734
32	Morphine addiction_Homo sapiens_hsa05032	1.30761275
33	Regulation of autophagy_Homo sapiens_hsa04140	1.29253439
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.27352407
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.24098920
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22788281
37	Collecting duct acid secretion_Homo sapiens_hsa04966	1.22152224
38	Insulin secretion_Homo sapiens_hsa04911	1.20003816
39	GABAergic synapse_Homo sapiens_hsa04727	1.15426401
40	Huntingtons disease_Homo sapiens_hsa05016	1.09751256
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.09242339
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.03660828
43	Alzheimers disease_Homo sapiens_hsa05010	1.02409661
44	Sulfur metabolism_Homo sapiens_hsa00920	1.01155546
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00807645
46	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.97572946
47	Cardiac muscle contraction_Homo sapiens_hsa04260	0.97497510
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.96172866
49	Serotonergic synapse_Homo sapiens_hsa04726	0.94383318
50	One carbon pool by folate_Homo sapiens_hsa00670	0.94251428
51	Circadian entrainment_Homo sapiens_hsa04713	0.92658467
52	Steroid biosynthesis_Homo sapiens_hsa00100	0.91466938
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.91045219
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.87451246
55	Circadian rhythm_Homo sapiens_hsa04710	0.85848061
56	ABC transporters_Homo sapiens_hsa02010	0.85125403
57	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83014706
58	Retinol metabolism_Homo sapiens_hsa00830	0.81892860
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80969625
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.80705426
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.79711280
62	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.78777705
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76369545
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74084453
65	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73926815
66	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.72127265
67	Salivary secretion_Homo sapiens_hsa04970	0.71497969
68	Purine metabolism_Homo sapiens_hsa00230	0.69814992
69	Proteasome_Homo sapiens_hsa03050	0.69760231
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67980639
71	Metabolic pathways_Homo sapiens_hsa01100	0.67338218
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.65165712
73	Dopaminergic synapse_Homo sapiens_hsa04728	0.63704183
74	Fatty acid metabolism_Homo sapiens_hsa01212	0.60733538
75	Fatty acid elongation_Homo sapiens_hsa00062	0.59578252
76	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.58803661
77	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.57178508
78	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.52623790
79	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.52151193
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50397928
81	Mineral absorption_Homo sapiens_hsa04978	0.49496160
82	Type I diabetes mellitus_Homo sapiens_hsa04940	0.49216229
83	Pyrimidine metabolism_Homo sapiens_hsa00240	0.49122453
84	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.45612285
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.45467434
86	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45282486
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44328757
88	Long-term depression_Homo sapiens_hsa04730	0.42905640
89	Fatty acid degradation_Homo sapiens_hsa00071	0.41362473
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39560686
91	Histidine metabolism_Homo sapiens_hsa00340	0.38791782
92	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.38452826
93	Sulfur relay system_Homo sapiens_hsa04122	0.38184929
94	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.36840406
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36665640
96	Non-homologous end-joining_Homo sapiens_hsa03450	0.35844846
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.34605663
98	Cocaine addiction_Homo sapiens_hsa05030	0.34222951
99	Gastric acid secretion_Homo sapiens_hsa04971	0.29966771
100	Amphetamine addiction_Homo sapiens_hsa05031	0.29611341

USP9YP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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