ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K11-linked deubiquitination (GO:0035871)	8.12333531
2	serotonin receptor signaling pathway (GO:0007210)	5.61800191
3	sulfation (GO:0051923)	5.18662032
4	regulation of appetite (GO:0032098)	4.63509839
5	negative regulation of mast cell activation (GO:0033004)	4.52361475
6	detection of light stimulus involved in visual perception (GO:0050908)	4.18130722
7	detection of light stimulus involved in sensory perception (GO:0050962)	4.18130722
8	behavioral response to nicotine (GO:0035095)	4.15435954
9	fucose catabolic process (GO:0019317)	3.91943651
10	L-fucose metabolic process (GO:0042354)	3.91943651
11	L-fucose catabolic process (GO:0042355)	3.91943651
12	adaptation of signaling pathway (GO:0023058)	3.82103117
13	organic cation transport (GO:0015695)	3.76407916
14	glycerophospholipid catabolic process (GO:0046475)	3.76242299
15	thyroid hormone metabolic process (GO:0042403)	3.63785430
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.59742622
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.59742622
18	NADH dehydrogenase complex assembly (GO:0010257)	3.59742622
19	protein complex biogenesis (GO:0070271)	3.59012907
20	regulation of hexokinase activity (GO:1903299)	3.57859018
21	regulation of glucokinase activity (GO:0033131)	3.57859018
22	protein-cofactor linkage (GO:0018065)	3.55136776
23	nephron epithelium morphogenesis (GO:0072088)	3.55120890
24	nephron tubule morphogenesis (GO:0072078)	3.55120890
25	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.54585884
26	interferon-gamma production (GO:0032609)	3.53151570
27	cellular ketone body metabolic process (GO:0046950)	3.52408780
28	dopamine transport (GO:0015872)	3.51666385
29	negative regulation of telomere maintenance (GO:0032205)	3.45391633
30	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.43920393
31	response to misfolded protein (GO:0051788)	3.35078350
32	negative regulation of interleukin-8 production (GO:0032717)	3.33812218
33	cysteine metabolic process (GO:0006534)	3.28540452
34	granulocyte differentiation (GO:0030851)	3.26938659
35	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.25640972
36	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.25640972
37	mitochondrial respiratory chain complex assembly (GO:0033108)	3.25267955
38	activated T cell proliferation (GO:0050798)	3.20634705
39	indole-containing compound catabolic process (GO:0042436)	3.18553502
40	indolalkylamine catabolic process (GO:0046218)	3.18553502
41	tryptophan catabolic process (GO:0006569)	3.18553502
42	carnitine metabolic process (GO:0009437)	3.16847378
43	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.15777679
44	negative regulation by host of viral transcription (GO:0043922)	3.14315066
45	ketone body metabolic process (GO:1902224)	3.13831343
46	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.11027464
47	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.09122978
48	reflex (GO:0060004)	3.08147588
49	amino-acid betaine metabolic process (GO:0006577)	3.03919343
50	response to pheromone (GO:0019236)	3.03841885
51	renal tubule morphogenesis (GO:0061333)	3.03059368
52	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.02719902
53	protein K63-linked deubiquitination (GO:0070536)	3.01928337
54	multicellular organism reproduction (GO:0032504)	2.99762015
55	hematopoietic stem cell proliferation (GO:0071425)	2.99158796
56	regulation of B cell receptor signaling pathway (GO:0050855)	2.97740824
57	positive regulation of hair cycle (GO:0042635)	2.96288653
58	positive regulation of hair follicle development (GO:0051798)	2.96288653
59	water-soluble vitamin biosynthetic process (GO:0042364)	2.92174103
60	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.91253782
61	disruption of cells of other organism (GO:0044364)	2.88572129
62	killing of cells of other organism (GO:0031640)	2.88572129
63	rRNA catabolic process (GO:0016075)	2.86720915
64	homocysteine metabolic process (GO:0050667)	2.86173362
65	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.86046095
66	ATP synthesis coupled proton transport (GO:0015986)	2.86046095
67	regulation of cilium movement (GO:0003352)	2.85305390
68	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.84878081
69	negative regulation of leukocyte chemotaxis (GO:0002689)	2.84370701
70	neuronal action potential propagation (GO:0019227)	2.84285901
71	lymphangiogenesis (GO:0001946)	2.82966675
72	startle response (GO:0001964)	2.81562245
73	cytochrome complex assembly (GO:0017004)	2.76090337
74	gamma-aminobutyric acid transport (GO:0015812)	2.72756820
75	auditory behavior (GO:0031223)	2.71843004
76	transmission of nerve impulse (GO:0019226)	2.69598362
77	mechanosensory behavior (GO:0007638)	2.69549458
78	respiratory chain complex IV assembly (GO:0008535)	2.68788569
79	DNA deamination (GO:0045006)	2.68540340
80	protein K48-linked deubiquitination (GO:0071108)	2.66642275
81	negative regulation of circadian rhythm (GO:0042754)	2.66106584
82	preassembly of GPI anchor in ER membrane (GO:0016254)	2.65886889
83	thyroid hormone generation (GO:0006590)	2.65071760
84	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.65013312
85	DNA double-strand break processing (GO:0000729)	2.63898312
86	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.63735068
87	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.63109727
88	nonmotile primary cilium assembly (GO:0035058)	2.62976557
89	proton transport (GO:0015992)	2.61791014
90	establishment of protein localization to Golgi (GO:0072600)	2.61205634
91	cilium morphogenesis (GO:0060271)	2.58257924
92	neuron fate determination (GO:0048664)	2.57960788
93	hydrogen transport (GO:0006818)	2.57410612
94	rhodopsin mediated signaling pathway (GO:0016056)	2.56972874
95	angiogenesis involved in wound healing (GO:0060055)	2.56731533
96	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.56551976
97	tyrosine phosphorylation of STAT protein (GO:0007260)	2.56107753
98	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.55551300
99	tryptophan metabolic process (GO:0006568)	2.55497323
100	cornea development in camera-type eye (GO:0061303)	2.55077652

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.36861085
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.71667854
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.15036620
4	VDR_22108803_ChIP-Seq_LS180_Human	2.62457805
5	IRF1_19129219_ChIP-ChIP_H3396_Human	2.53316715
6	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.52534636
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.39309005
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.15097212
9	TP53_22573176_ChIP-Seq_HFKS_Human	2.11458770
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.11353193
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.07744215
12	ER_23166858_ChIP-Seq_MCF-7_Human	2.07471776
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.99671206
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.99487796
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.98912395
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.94133163
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91256146
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.88546308
19	EZH2_22144423_ChIP-Seq_EOC_Human	1.87283817
20	FUS_26573619_Chip-Seq_HEK293_Human	1.85892969
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.84143379
22	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.77612880
23	EWS_26573619_Chip-Seq_HEK293_Human	1.74218412
24	AR_25329375_ChIP-Seq_VCAP_Human	1.72041780
25	P300_19829295_ChIP-Seq_ESCs_Human	1.68074632
26	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.53113210
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48811776
28	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.47696709
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45376108
30	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.44939636
31	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.43900000
32	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.42722635
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.42398218
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42398218
35	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.41997553
36	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.38263287
37	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.37882913
38	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.36414721
39	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.35797463
40	MYC_18940864_ChIP-ChIP_HL60_Human	1.35397937
41	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33642241
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32229543
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.31144291
44	STAT3_23295773_ChIP-Seq_U87_Human	1.30558533
45	TCF4_23295773_ChIP-Seq_U87_Human	1.29266349
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.29071517
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28543320
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28543320
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.27934316
50	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.27107925
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.25915638
52	NCOR_22424771_ChIP-Seq_293T_Human	1.25578895
53	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.24339001
54	AR_21572438_ChIP-Seq_LNCaP_Human	1.24055591
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23239693
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23239693
57	HOXB7_26014856_ChIP-Seq_BT474_Human	1.22324145
58	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.21678830
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21606692
60	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21605336
61	REST_21632747_ChIP-Seq_MESCs_Mouse	1.20919273
62	TP53_16413492_ChIP-PET_HCT116_Human	1.19560131
63	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.19498720
64	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19447327
65	PHF8_20622853_ChIP-Seq_HELA_Human	1.18804258
66	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.18580409
67	VDR_23849224_ChIP-Seq_CD4+_Human	1.17270511
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16009642
69	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.15899413
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.15605514
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.14786769
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14344652
73	ERG_20517297_ChIP-Seq_VCAP_Human	1.13245265
74	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.12787264
75	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12670596
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12031763
77	ETV1_20927104_ChIP-Seq_GIST48_Human	1.11029849
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.10960588
79	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10779979
80	RBPJ_21746931_ChIP-Seq_IB4_Human	1.10079084
81	JUN_21703547_ChIP-Seq_K562_Human	1.08504792
82	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.07699305
83	AR_20517297_ChIP-Seq_VCAP_Human	1.07112606
84	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.07094564
85	ERA_21632823_ChIP-Seq_H3396_Human	1.06492643
86	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.06441359
87	MYC_19829295_ChIP-Seq_ESCs_Human	1.05927277
88	DROSHA_22980978_ChIP-Seq_HELA_Human	1.05699980
89	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.05668099
90	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05348398
91	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.05053173
92	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.04729719
93	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.03758060
94	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.01761019
95	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.01646323
96	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.01502099
97	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.01428235
98	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.00954619
99	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.00577542
100	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00408435

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	3.10875954
2	MP0001984_abnormal_olfaction	2.93563808
3	MP0003183_abnormal_peptide_metabolism	2.93492622
4	MP0002138_abnormal_hepatobiliary_system	2.77777422
5	MP0003136_yellow_coat_color	2.74283922
6	MP0005551_abnormal_eye_electrophysiolog	2.63394500
7	MP0005084_abnormal_gallbladder_morpholo	2.36291476
8	MP0003806_abnormal_nucleotide_metabolis	2.22489818
9	MP0001968_abnormal_touch/_nociception	2.16676333
10	MP0003878_abnormal_ear_physiology	2.16072203
11	MP0005377_hearing/vestibular/ear_phenot	2.16072203
12	MP0002139_abnormal_hepatobiliary_system	2.11955579
13	MP0001986_abnormal_taste_sensitivity	2.07784928
14	MP0001529_abnormal_vocalization	2.06827602
15	MP0006276_abnormal_autonomic_nervous	2.04687060
16	MP0004142_abnormal_muscle_tone	2.03322195
17	MP0002876_abnormal_thyroid_physiology	2.03024145
18	MP0000372_irregular_coat_pigmentation	2.02734895
19	MP0009046_muscle_twitch	1.99956795
20	MP0004043_abnormal_pH_regulation	1.94777671
21	MP0006292_abnormal_olfactory_placode	1.90630001
22	MP0002736_abnormal_nociception_after	1.88019164
23	MP0005310_abnormal_salivary_gland	1.83497043
24	MP0004147_increased_porphyrin_level	1.72643570
25	MP0004742_abnormal_vestibular_system	1.69646497
26	MP0005253_abnormal_eye_physiology	1.66060064
27	MP0002102_abnormal_ear_morphology	1.65677856
28	MP0009745_abnormal_behavioral_response	1.65564858
29	MP0002928_abnormal_bile_duct	1.65210429
30	MP0005379_endocrine/exocrine_gland_phen	1.63831091
31	MP0008872_abnormal_physiological_respon	1.63334790
32	MP0003195_calcinosis	1.57161309
33	MP0001764_abnormal_homeostasis	1.56410530
34	MP0002272_abnormal_nervous_system	1.52181476
35	MP0003011_delayed_dark_adaptation	1.51863653
36	MP0001873_stomach_inflammation	1.50502441
37	MP0005645_abnormal_hypothalamus_physiol	1.43602031
38	MP0001919_abnormal_reproductive_system	1.43378471
39	MP0001485_abnormal_pinna_reflex	1.43080180
40	MP0000631_abnormal_neuroendocrine_gland	1.42622432
41	MP0005646_abnormal_pituitary_gland	1.42141320
42	MP0001486_abnormal_startle_reflex	1.36746932
43	MP0008877_abnormal_DNA_methylation	1.36440947
44	MP0000427_abnormal_hair_cycle	1.34440320
45	MP0005389_reproductive_system_phenotype	1.32230825
46	MP0002277_abnormal_respiratory_mucosa	1.31570862
47	MP0006072_abnormal_retinal_apoptosis	1.29552340
48	MP0002638_abnormal_pupillary_reflex	1.27639010
49	MP0000230_abnormal_systemic_arterial	1.26352116
50	MP0002064_seizures	1.24979857
51	MP0002837_dystrophic_cardiac_calcinosis	1.24221126
52	MP0001905_abnormal_dopamine_level	1.21896629
53	MP0002163_abnormal_gland_morphology	1.17228592
54	MP0002735_abnormal_chemical_nociception	1.15069704
55	MP0003283_abnormal_digestive_organ	1.13496409
56	MP0010386_abnormal_urinary_bladder	1.13432028
57	MP0000647_abnormal_sebaceous_gland	1.13301338
58	MP0002938_white_spotting	1.13063096
59	MP0002067_abnormal_sensory_capabilities	1.09081000
60	MP0000383_abnormal_hair_follicle	1.08168795
61	MP0002572_abnormal_emotion/affect_behav	1.07962582
62	MP0008058_abnormal_DNA_repair	1.07438004
63	MP0004133_heterotaxia	1.06650342
64	MP0005410_abnormal_fertilization	1.05963727
65	MP0003880_abnormal_central_pattern	1.05742472
66	MP0001970_abnormal_pain_threshold	1.05490728
67	MP0000613_abnormal_salivary_gland	1.03568813
68	MP0004145_abnormal_muscle_electrophysio	1.03503495
69	MP0001348_abnormal_lacrimal_gland	1.03409292
70	MP0001501_abnormal_sleep_pattern	0.98666667
71	MP0005187_abnormal_penis_morphology	0.98095480
72	MP0002557_abnormal_social/conspecific_i	0.96053148
73	MP0002254_reproductive_system_inflammat	0.94713402
74	MP0002234_abnormal_pharynx_morphology	0.94009078
75	MP0004885_abnormal_endolymph	0.93972389
76	MP0002095_abnormal_skin_pigmentation	0.93942164
77	MP0001270_distended_abdomen	0.92270621
78	MP0003252_abnormal_bile_duct	0.91533628
79	MP0010329_abnormal_lipoprotein_level	0.90855555
80	MP0005195_abnormal_posterior_eye	0.90746661
81	MP0000026_abnormal_inner_ear	0.88936191
82	MP0005332_abnormal_amino_acid	0.88560570
83	MP0003646_muscle_fatigue	0.86960358
84	MP0005671_abnormal_response_to	0.85114396
85	MP0005085_abnormal_gallbladder_physiolo	0.84882395
86	MP0002160_abnormal_reproductive_system	0.84595175
87	MP0002734_abnormal_mechanical_nocicepti	0.83378090
88	MP0004924_abnormal_behavior	0.82452279
89	MP0005386_behavior/neurological_phenoty	0.82452279
90	MP0002909_abnormal_adrenal_gland	0.82277901
91	MP0001324_abnormal_eye_pigmentation	0.80276224
92	MP0005670_abnormal_white_adipose	0.78761754
93	MP0008789_abnormal_olfactory_epithelium	0.77958509
94	MP0002751_abnormal_autonomic_nervous	0.76811436
95	MP0003635_abnormal_synaptic_transmissio	0.76129144
96	MP0001664_abnormal_digestion	0.73374377
97	MP0002210_abnormal_sex_determination	0.72586873
98	MP0002733_abnormal_thermal_nociception	0.71454247
99	MP0004019_abnormal_vitamin_homeostasis	0.70627113
100	MP0003698_abnormal_male_reproductive	0.70036893

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.50239535
2	Congenital stationary night blindness (HP:0007642)	4.46413936
3	Pancreatic fibrosis (HP:0100732)	4.05192724
4	True hermaphroditism (HP:0010459)	3.92405525
5	Abolished electroretinogram (ERG) (HP:0000550)	3.66323498
6	Type II lissencephaly (HP:0007260)	3.43924663
7	Abnormality of alanine metabolism (HP:0010916)	3.43294697
8	Hyperalaninemia (HP:0003348)	3.43294697
9	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.43294697
10	Molar tooth sign on MRI (HP:0002419)	3.38689885
11	Abnormality of midbrain morphology (HP:0002418)	3.38689885
12	Chronic hepatic failure (HP:0100626)	3.31182155
13	Medial flaring of the eyebrow (HP:0010747)	3.23339662
14	Nephronophthisis (HP:0000090)	3.22393930
15	Attenuation of retinal blood vessels (HP:0007843)	3.19165379
16	Congenital sensorineural hearing impairment (HP:0008527)	3.11903620
17	Abnormal biliary tract physiology (HP:0012439)	2.99583388
18	Bile duct proliferation (HP:0001408)	2.99583388
19	Acute necrotizing encephalopathy (HP:0006965)	2.97595565
20	Acute encephalopathy (HP:0006846)	2.83765698
21	Abnormal pancreas size (HP:0012094)	2.80552374
22	Hyperventilation (HP:0002883)	2.78278606
23	3-Methylglutaconic aciduria (HP:0003535)	2.74391961
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.73275499
25	Hypoplasia of the uterus (HP:0000013)	2.72306674
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.70998455
27	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.70756829
28	Abnormal drinking behavior (HP:0030082)	2.66634510
29	Polydipsia (HP:0001959)	2.66634510
30	Abnormality of the renal medulla (HP:0100957)	2.64708651
31	Cystic liver disease (HP:0006706)	2.63866899
32	Tubular atrophy (HP:0000092)	2.62057428
33	Hyperglycinuria (HP:0003108)	2.61587382
34	Cerebellar dysplasia (HP:0007033)	2.61431292
35	Abnormality of the renal cortex (HP:0011035)	2.59313923
36	Decreased circulating renin level (HP:0003351)	2.58846603
37	Hepatocellular necrosis (HP:0001404)	2.57976849
38	Mitochondrial inheritance (HP:0001427)	2.53730942
39	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.51024733
40	Abnormal mitochondria in muscle tissue (HP:0008316)	2.49542022
41	Aplasia/hypoplasia of the uterus (HP:0008684)	2.45761358
42	Abnormal number of erythroid precursors (HP:0012131)	2.42797999
43	Progressive macrocephaly (HP:0004481)	2.40538071
44	Congenital primary aphakia (HP:0007707)	2.40264689
45	Gait imbalance (HP:0002141)	2.38473828
46	Nephrogenic diabetes insipidus (HP:0009806)	2.33070246
47	Increased CSF lactate (HP:0002490)	2.32816718
48	Hepatic necrosis (HP:0002605)	2.32570506
49	Optic nerve hypoplasia (HP:0000609)	2.28572659
50	Concave nail (HP:0001598)	2.28566230
51	Asplenia (HP:0001746)	2.27677532
52	Bony spicule pigmentary retinopathy (HP:0007737)	2.27320747
53	Abnormality of cells of the erythroid lineage (HP:0012130)	2.25903424
54	Optic disc pallor (HP:0000543)	2.24547892
55	Male pseudohermaphroditism (HP:0000037)	2.15645200
56	Retrobulbar optic neuritis (HP:0100654)	2.13936956
57	Optic neuritis (HP:0100653)	2.13936956
58	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.12812356
59	Stomatitis (HP:0010280)	2.11236962
60	Abnormality of glycine metabolism (HP:0010895)	2.10054221
61	Abnormality of serine family amino acid metabolism (HP:0010894)	2.10054221
62	Amelogenesis imperfecta (HP:0000705)	2.09171243
63	Hyperglycinemia (HP:0002154)	2.06599446
64	Cerebral edema (HP:0002181)	2.03702919
65	Occipital encephalocele (HP:0002085)	2.03606702
66	Genital tract atresia (HP:0001827)	2.02796056
67	Retinal dysplasia (HP:0007973)	2.02116009
68	Severe muscular hypotonia (HP:0006829)	2.01587649
69	Increased corneal curvature (HP:0100692)	2.00230294
70	Keratoconus (HP:0000563)	2.00230294
71	Pendular nystagmus (HP:0012043)	1.99286825
72	Decreased central vision (HP:0007663)	1.99093295
73	Lissencephaly (HP:0001339)	1.97030674
74	Keratoconjunctivitis (HP:0001096)	1.97017365
75	Vaginal atresia (HP:0000148)	1.95698979
76	Sclerocornea (HP:0000647)	1.94715356
77	Abnormality of dental color (HP:0011073)	1.93211280
78	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.90170863
79	Ketosis (HP:0001946)	1.88888670
80	Arthropathy (HP:0003040)	1.87702147
81	Polyuria (HP:0000103)	1.85797691
82	Constricted visual fields (HP:0001133)	1.85677819
83	Tachypnea (HP:0002789)	1.83729765
84	Large for gestational age (HP:0001520)	1.79257525
85	Congenital hepatic fibrosis (HP:0002612)	1.78921078
86	Anophthalmia (HP:0000528)	1.77691619
87	Retinitis pigmentosa (HP:0000510)	1.77328902
88	Spastic tetraparesis (HP:0001285)	1.77305641
89	Hypothermia (HP:0002045)	1.75048073
90	Albinism (HP:0001022)	1.74980441
91	Lactic acidosis (HP:0003128)	1.74932750
92	Left ventricular hypertrophy (HP:0001712)	1.74906250
93	Abnormality of urine glucose concentration (HP:0011016)	1.74586531
94	Glycosuria (HP:0003076)	1.74586531
95	Gaze-evoked nystagmus (HP:0000640)	1.74404868
96	Generalized aminoaciduria (HP:0002909)	1.71978191
97	Stage 5 chronic kidney disease (HP:0003774)	1.71780597
98	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.71690293
99	Retinal atrophy (HP:0001105)	1.71289065
100	Pachygyria (HP:0001302)	1.70007458

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.56953359
2	WNK3	4.03900422
3	BRSK2	3.82896917
4	TAOK3	3.24437969
5	WNK4	3.12687633
6	BMPR1B	2.88542815
7	ADRBK2	2.88247264
8	TXK	2.64889645
9	GRK1	2.57834884
10	PINK1	2.53007938
11	WEE1	2.51823552
12	ZAK	2.15058985
13	CASK	2.13791856
14	MAP4K2	1.99915483
15	BCKDK	1.68488955
16	STK39	1.66646956
17	MAP3K4	1.59280299
18	TIE1	1.49836132
19	NUAK1	1.46828631
20	MAPK13	1.43875507
21	STK16	1.39183387
22	TEC	1.21877414
23	TLK1	1.21385617
24	BRSK1	1.18583855
25	VRK2	1.18515015
26	EIF2AK3	1.14589593
27	MAP2K7	1.12184041
28	FER	1.03586534
29	ITK	0.99736947
30	DYRK3	0.98990113
31	PRKCQ	0.97156568
32	IRAK1	0.95755468
33	NTRK3	0.95082558
34	DYRK2	0.94851210
35	OXSR1	0.93601731
36	DAPK2	0.90468385
37	MAPKAPK3	0.87855968
38	MAPKAPK5	0.86433986
39	MARK1	0.85958560
40	INSRR	0.85215357
41	PNCK	0.85124699
42	MUSK	0.78410556
43	STK38L	0.77700210
44	PRKCG	0.76833853
45	IKBKB	0.75480661
46	ADRBK1	0.74859496
47	MAPK15	0.72920205
48	CAMKK2	0.71907666
49	TRIM28	0.69814416
50	PAK3	0.64598446
51	PRKCE	0.63671343
52	PRKCZ	0.62675949
53	CDK8	0.61071347
54	PDK2	0.60753410
55	RPS6KA5	0.58645343
56	PRKACA	0.57779885
57	CAMK2D	0.57142755
58	TGFBR1	0.55984307
59	PRKCA	0.53611372
60	BTK	0.52960035
61	MKNK2	0.52448767
62	NME1	0.52260974
63	PLK2	0.49922332
64	WNK1	0.49219420
65	EPHA4	0.49156712
66	PIK3CA	0.48986073
67	CSNK1A1	0.46341075
68	EPHB2	0.44616973
69	CSNK1G2	0.44319395
70	VRK1	0.44291882
71	PHKG1	0.44045753
72	PHKG2	0.44045753
73	PASK	0.42715587
74	TNK2	0.41894579
75	IGF1R	0.41070579
76	IKBKE	0.38792379
77	OBSCN	0.38659586
78	CAMK2A	0.38348406
79	FLT3	0.37950696
80	PRKG1	0.37511427
81	TAF1	0.36992288
82	CSNK1D	0.35278317
83	CSNK1G3	0.34214363
84	TRPM7	0.34031591
85	PRKD2	0.33757860
86	MAP3K10	0.33089011
87	CHEK2	0.31963793
88	LYN	0.31770937
89	KDR	0.31374309
90	CHUK	0.31022176
91	CAMK2B	0.31012906
92	GRK7	0.29592326
93	CSNK1G1	0.29304916
94	MAP3K7	0.29242061
95	PRKCB	0.28745268
96	CSNK2A1	0.28178986
97	GRK5	0.26971534
98	RPS6KA6	0.26449788
99	PRKACB	0.26401853
100	PLK1	0.26254220

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.17782265
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.91312261
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.83496387
4	Phototransduction_Homo sapiens_hsa04744	2.52389454
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.43197935
6	Ether lipid metabolism_Homo sapiens_hsa00565	2.42555022
7	Homologous recombination_Homo sapiens_hsa03440	2.33068227
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.27309592
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.23861019
10	Parkinsons disease_Homo sapiens_hsa05012	2.21920559
11	Butanoate metabolism_Homo sapiens_hsa00650	1.98691094
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.95636619
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.92991731
14	Nicotine addiction_Homo sapiens_hsa05033	1.90504112
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.86014045
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.85085477
17	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.77813137
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.75530436
19	Proteasome_Homo sapiens_hsa03050	1.74843885
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.69509656
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.66698595
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.61227280
23	Fat digestion and absorption_Homo sapiens_hsa04975	1.59526589
24	Propanoate metabolism_Homo sapiens_hsa00640	1.59384688
25	Ribosome_Homo sapiens_hsa03010	1.55733708
26	Olfactory transduction_Homo sapiens_hsa04740	1.50810713
27	Protein export_Homo sapiens_hsa03060	1.48552073
28	Huntingtons disease_Homo sapiens_hsa05016	1.40770915
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.35083523
30	RNA polymerase_Homo sapiens_hsa03020	1.34053290
31	Alzheimers disease_Homo sapiens_hsa05010	1.25596732
32	Regulation of autophagy_Homo sapiens_hsa04140	1.25176689
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.24643200
34	Basal transcription factors_Homo sapiens_hsa03022	1.24213057
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.22230321
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.21003961
37	Peroxisome_Homo sapiens_hsa04146	1.17721347
38	Serotonergic synapse_Homo sapiens_hsa04726	1.13059708
39	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.08113598
40	Morphine addiction_Homo sapiens_hsa05032	1.07782263
41	ABC transporters_Homo sapiens_hsa02010	1.05589968
42	Primary immunodeficiency_Homo sapiens_hsa05340	1.05563868
43	Collecting duct acid secretion_Homo sapiens_hsa04966	1.04451728
44	Tryptophan metabolism_Homo sapiens_hsa00380	1.04018832
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.01249573
46	Fanconi anemia pathway_Homo sapiens_hsa03460	1.00742320
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.98397859
48	Taste transduction_Homo sapiens_hsa04742	0.98395395
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.97144901
50	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.95944708
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94556576
52	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.92148236
53	RNA degradation_Homo sapiens_hsa03018	0.92062769
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.88774998
55	Sulfur relay system_Homo sapiens_hsa04122	0.87280257
56	GABAergic synapse_Homo sapiens_hsa04727	0.86364502
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.85471986
58	One carbon pool by folate_Homo sapiens_hsa00670	0.83582849
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.83459928
60	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.82605497
61	Calcium signaling pathway_Homo sapiens_hsa04020	0.79778036
62	Retinol metabolism_Homo sapiens_hsa00830	0.79558594
63	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.76388309
64	Metabolic pathways_Homo sapiens_hsa01100	0.75887884
65	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.75495123
66	Histidine metabolism_Homo sapiens_hsa00340	0.75488335
67	Caffeine metabolism_Homo sapiens_hsa00232	0.74502596
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73844958
69	Fatty acid degradation_Homo sapiens_hsa00071	0.70481802
70	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.70051846
71	Asthma_Homo sapiens_hsa05310	0.68227451
72	Salivary secretion_Homo sapiens_hsa04970	0.68052650
73	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66634301
74	Insulin secretion_Homo sapiens_hsa04911	0.66240193
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64567134
76	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.64186116
77	Sphingolipid metabolism_Homo sapiens_hsa00600	0.62914126
78	Nucleotide excision repair_Homo sapiens_hsa03420	0.61935590
79	Glutathione metabolism_Homo sapiens_hsa00480	0.60224757
80	Graft-versus-host disease_Homo sapiens_hsa05332	0.58012531
81	Purine metabolism_Homo sapiens_hsa00230	0.57942504
82	Type I diabetes mellitus_Homo sapiens_hsa04940	0.56944815
83	cAMP signaling pathway_Homo sapiens_hsa04024	0.56656284
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55835964
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55730367
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55195474
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53047604
88	Pyrimidine metabolism_Homo sapiens_hsa00240	0.49110580
89	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.48452295
90	Base excision repair_Homo sapiens_hsa03410	0.46559544
91	Allograft rejection_Homo sapiens_hsa05330	0.46394060
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.46275201
93	Sulfur metabolism_Homo sapiens_hsa00920	0.42976553
94	Rheumatoid arthritis_Homo sapiens_hsa05323	0.42356919
95	Pancreatic secretion_Homo sapiens_hsa04972	0.39549919
96	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39173353
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.38609589
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37527815
99	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37270184
100	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.34368628

USP9YP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »