UST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.88143350
2neuron cell-cell adhesion (GO:0007158)5.19165240
3paraxial mesoderm development (GO:0048339)4.84396543
4exploration behavior (GO:0035640)4.80471734
5activated T cell proliferation (GO:0050798)4.64699906
6neuronal action potential propagation (GO:0019227)4.55075176
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.52485645
8vocalization behavior (GO:0071625)4.47161403
9amino acid import (GO:0043090)4.46384597
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.42000565
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.41567184
12kidney mesenchyme development (GO:0072074)4.25189761
13metanephric mesenchyme development (GO:0072075)4.23070851
14L-amino acid import (GO:0043092)4.19525494
15synaptic vesicle maturation (GO:0016188)4.13897126
16cerebellar granule cell differentiation (GO:0021707)4.08895850
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.04643244
18glutamate receptor signaling pathway (GO:0007215)4.02799102
19regulation of synaptic vesicle exocytosis (GO:2000300)3.98252839
20transmission of nerve impulse (GO:0019226)3.95601296
21* dermatan sulfate biosynthetic process (GO:0030208)3.90949241
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.89760284
23dendrite morphogenesis (GO:0048813)3.84138463
24synaptic vesicle exocytosis (GO:0016079)3.83173956
25dendritic spine morphogenesis (GO:0060997)3.81550683
26anterior/posterior axis specification, embryo (GO:0008595)3.74952251
27protein localization to synapse (GO:0035418)3.70438376
28synaptic transmission, glutamatergic (GO:0035249)3.67950887
29neuron recognition (GO:0008038)3.67573895
30glutamate secretion (GO:0014047)3.64019531
31regulation of glutamate receptor signaling pathway (GO:1900449)3.60718428
32long-term synaptic potentiation (GO:0060291)3.60519159
33chondrocyte proliferation (GO:0035988)3.60495640
34presynaptic membrane assembly (GO:0097105)3.50584072
35* dermatan sulfate metabolic process (GO:0030205)3.45844989
36neuron-neuron synaptic transmission (GO:0007270)3.44037658
37negative regulation of axon extension involved in axon guidance (GO:0048843)3.43982369
38regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.42972872
39axonal fasciculation (GO:0007413)3.42731352
40neuronal ion channel clustering (GO:0045161)3.42056363
41regulation of synaptic vesicle transport (GO:1902803)3.41495526
42regulation of axon extension involved in axon guidance (GO:0048841)3.40410141
43positive regulation of catenin import into nucleus (GO:0035413)3.40277133
44myelination (GO:0042552)3.39607490
45positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.39112095
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.38658579
47ensheathment of neurons (GO:0007272)3.38047329
48axon ensheathment (GO:0008366)3.38047329
49epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.35040261
50regulation of neuronal synaptic plasticity (GO:0048168)3.33419580
51neurotransmitter-gated ion channel clustering (GO:0072578)3.32667322
52planar cell polarity pathway involved in neural tube closure (GO:0090179)3.32473300
53presynaptic membrane organization (GO:0097090)3.31137169
54chondrocyte development (GO:0002063)3.30973944
55regulation of gene silencing by miRNA (GO:0060964)3.29607330
56regulation of gene silencing by RNA (GO:0060966)3.29607330
57regulation of posttranscriptional gene silencing (GO:0060147)3.29607330
58myelination in peripheral nervous system (GO:0022011)3.25460231
59peripheral nervous system axon ensheathment (GO:0032292)3.25460231
60long-term memory (GO:0007616)3.24927274
61neurotransmitter secretion (GO:0007269)3.23905261
62axon ensheathment in central nervous system (GO:0032291)3.21580322
63central nervous system myelination (GO:0022010)3.21580322
64gamma-aminobutyric acid transport (GO:0015812)3.20621097
65regulation of excitatory postsynaptic membrane potential (GO:0060079)3.18104589
66lateral sprouting from an epithelium (GO:0060601)3.17860198
67regulation of dendritic spine morphogenesis (GO:0061001)3.17833619
68gamma-aminobutyric acid signaling pathway (GO:0007214)3.16855338
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15702313
70outer ear morphogenesis (GO:0042473)3.14355220
71postsynaptic membrane organization (GO:0001941)3.11685639
72mesenchymal-epithelial cell signaling (GO:0060638)3.10562676
73neuromuscular process controlling balance (GO:0050885)3.09436789
74cell migration involved in sprouting angiogenesis (GO:0002042)3.08720957
75negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.08036846
76cell surface receptor signaling pathway involved in heart development (GO:0061311)3.06665176
77layer formation in cerebral cortex (GO:0021819)3.06072098
78C4-dicarboxylate transport (GO:0015740)3.04375520
79regulation of synaptic transmission, glutamatergic (GO:0051966)3.03481494
80positive regulation of SMAD protein import into nucleus (GO:0060391)3.02799615
81positive regulation of membrane potential (GO:0045838)3.01975750
82regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.01130089
83regulation of axon regeneration (GO:0048679)3.01085831
84regulation of neuron projection regeneration (GO:0070570)3.01085831
85regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.00723336
86regulation of synaptic plasticity (GO:0048167)2.99320471
87regulation of axon guidance (GO:1902667)2.99174111
88regulation of catenin import into nucleus (GO:0035412)2.98672255
89cellular potassium ion homeostasis (GO:0030007)2.97593387
90regulation of synapse structural plasticity (GO:0051823)2.94153709
91regulation of postsynaptic membrane potential (GO:0060078)2.93324942
92convergent extension (GO:0060026)2.92295080
93synapse assembly (GO:0007416)2.91912106
94cellular response to epinephrine stimulus (GO:0071872)2.91224134
95cerebellar Purkinje cell differentiation (GO:0021702)2.89734279
96synapse organization (GO:0050808)2.88966301
97negative regulation of chondrocyte differentiation (GO:0032331)2.87970511
98long-chain fatty acid biosynthetic process (GO:0042759)2.87262805
99regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86139184
100negative regulation of axon extension (GO:0030517)2.85710049
101Notch signaling involved in heart development (GO:0061314)2.84379337
102positive regulation of synapse assembly (GO:0051965)2.83754083
103negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.83562309
104establishment of tissue polarity (GO:0007164)2.83124076
105establishment of planar polarity (GO:0001736)2.83124076
106dendritic spine organization (GO:0097061)2.82752707
107regulation of cell fate specification (GO:0042659)2.81960341
108regulation of voltage-gated calcium channel activity (GO:1901385)2.80523536
109negative regulation of axon guidance (GO:1902668)2.79604463
110regulation of dendritic spine development (GO:0060998)2.79521959
111collagen fibril organization (GO:0030199)2.79043262
112negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78900392
113membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.78754684
114adult walking behavior (GO:0007628)2.78180028
115learning (GO:0007612)2.76182131
116sodium ion export (GO:0071436)2.75687302
117axon extension involved in axon guidance (GO:0048846)2.74285515
118neuron projection extension involved in neuron projection guidance (GO:1902284)2.74285515
119negative regulation of axonogenesis (GO:0050771)2.74204959
120pre-miRNA processing (GO:0031054)2.73540733
121dorsal/ventral axis specification (GO:0009950)2.73379484
122innervation (GO:0060384)2.72603806
123lung-associated mesenchyme development (GO:0060484)2.71858014
124positive regulation of synapse maturation (GO:0090129)2.69610999
125startle response (GO:0001964)2.69461359
126negative regulation of neurotransmitter transport (GO:0051589)2.67101707
127cardiac epithelial to mesenchymal transition (GO:0060317)2.64773918
128mesenchyme morphogenesis (GO:0072132)2.64090054
129positive regulation of neurological system process (GO:0031646)2.63346577
130response to epinephrine (GO:0071871)2.63107207
131generation of neurons (GO:0048699)2.62753072
132vesicle transport along microtubule (GO:0047496)2.62713820
133negative regulation of neurotransmitter secretion (GO:0046929)2.62009052
134cell differentiation in hindbrain (GO:0021533)2.61876101
135cell-cell signaling involved in cell fate commitment (GO:0045168)2.61586702
136regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.61418842
137response to methylmercury (GO:0051597)2.60915641
138synaptic vesicle endocytosis (GO:0048488)2.60712108
139positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.59698847
140neuromuscular process (GO:0050905)2.59494669
141protein heterotrimerization (GO:0070208)2.58715320
142synaptic vesicle docking involved in exocytosis (GO:0016081)2.58552749
143proline transport (GO:0015824)2.58283824
144neurotransmitter transport (GO:0006836)2.57539674
145negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.55443511
146negative regulation of BMP signaling pathway (GO:0030514)2.53943587
147notochord development (GO:0030903)2.53747868
148hippo signaling (GO:0035329)2.52723285
149negative regulation of androgen receptor signaling pathway (GO:0060766)2.52644162
150branching involved in salivary gland morphogenesis (GO:0060445)2.52260032
151developmental induction (GO:0031128)2.50002583
152chondroitin sulfate biosynthetic process (GO:0030206)2.48476055
153cell migration involved in heart development (GO:0060973)2.42029518
154morphogenesis of an epithelial sheet (GO:0002011)2.41994061
155Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.41508683
156semaphorin-plexin signaling pathway (GO:0071526)2.40990629
157regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.39530953
158regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.39496570
159post-anal tail morphogenesis (GO:0036342)2.37424896
160positive regulation of mesenchymal cell proliferation (GO:0002053)2.36969521
161regulation of somitogenesis (GO:0014807)2.36456607
162negative chemotaxis (GO:0050919)2.35729744
163membrane assembly (GO:0071709)2.35139143
164embryonic eye morphogenesis (GO:0048048)2.35118198
165mesenchymal cell differentiation (GO:0048762)2.35072871
166establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.32930708
167negative regulation of embryonic development (GO:0045992)2.32577673
168protein complex localization (GO:0031503)2.31921869
169establishment of apical/basal cell polarity (GO:0035089)2.31850569
170mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.30816445
171mesenchymal to epithelial transition (GO:0060231)2.29455580
172eye morphogenesis (GO:0048592)2.28473049
173glomerular basement membrane development (GO:0032836)2.28201764
174bone trabecula formation (GO:0060346)2.27366655
175neuron remodeling (GO:0016322)2.26596185
176embryonic digit morphogenesis (GO:0042733)2.26580017
177regulation of establishment of planar polarity (GO:0090175)2.26385190
178astrocyte development (GO:0014002)2.25159676
179negative regulation of keratinocyte proliferation (GO:0010839)2.24721225
180stem cell division (GO:0017145)2.24559131
181craniofacial suture morphogenesis (GO:0097094)2.24484155
182dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.22496430
183non-canonical Wnt signaling pathway (GO:0035567)2.21629537
184glomerular visceral epithelial cell development (GO:0072015)2.21143328
185smooth muscle tissue development (GO:0048745)2.20619437
186cellular protein complex localization (GO:0034629)2.20126668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.49677632
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.30400615
3GBX2_23144817_ChIP-Seq_PC3_Human3.05283809
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04339428
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94308687
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89421917
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68294529
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68294529
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56029259
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48645010
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45221816
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44379292
13AR_21572438_ChIP-Seq_LNCaP_Human2.42757118
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36597040
15DROSHA_22980978_ChIP-Seq_HELA_Human2.32757748
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30686156
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.29513988
18SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.21779549
19* EED_16625203_ChIP-ChIP_MESCs_Mouse2.19180702
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.17235048
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.16236862
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.15989200
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.15989200
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.15989200
25* EZH2_27294783_Chip-Seq_ESCs_Mouse2.12012624
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06087360
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97776618
28REST_21632747_ChIP-Seq_MESCs_Mouse1.96932481
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.93017304
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.89793194
31* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.85595482
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80710659
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79211892
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76945907
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72827265
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.70850594
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67066166
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.62394685
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60511606
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.59518196
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58339473
42* SMAD4_21799915_ChIP-Seq_A2780_Human1.57995410
43* ISL1_27105846_Chip-Seq_CPCs_Mouse1.56454779
44* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56234173
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.55379852
46TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.55167494
47TBX3_20139965_ChIP-Seq_MESCs_Mouse1.53706380
48TBX3_20139965_ChIP-Seq_ESCs_Mouse1.53669186
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51686936
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48121643
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46829749
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44939274
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44157001
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43765447
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43744154
56TAF15_26573619_Chip-Seq_HEK293_Human1.43224738
57ZNF274_21170338_ChIP-Seq_K562_Hela1.43185877
58TP53_16413492_ChIP-PET_HCT116_Human1.42070348
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41908397
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.41331796
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40185231
62TP53_20018659_ChIP-ChIP_R1E_Mouse1.38453188
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38099909
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.35728428
65STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.34747445
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33735616
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.33631220
68* SOX9_26525672_Chip-Seq_HEART_Mouse1.32215776
69* P300_19829295_ChIP-Seq_ESCs_Human1.31255692
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31056696
71* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30447923
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.29037343
73* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28890070
74* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28760378
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28565102
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.26345536
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26005420
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25811283
79POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.24378832
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24366064
81AHR_22903824_ChIP-Seq_MCF-7_Human1.23256022
82* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22340624
83* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22156007
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21404963
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21223349
86* STAT3_23295773_ChIP-Seq_U87_Human1.20057465
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.19938855
88* RING1B_27294783_Chip-Seq_ESCs_Mouse1.19857263
89BRD4_25478319_ChIP-Seq_HGPS_Human1.19747751
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19678479
91AR_25329375_ChIP-Seq_VCAP_Human1.19359939
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19064371
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19062602
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.18785637
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18245224
96TCF3_18692474_ChIP-Seq_MESCs_Mouse1.18144865
97* RING1B_27294783_Chip-Seq_NPCs_Mouse1.17531114
98TP63_17297297_ChIP-ChIP_HaCaT_Human1.15811390
99TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14383586
100* AR_19668381_ChIP-Seq_PC3_Human1.13860690
101* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12819884
102CBX2_27304074_Chip-Seq_ESCs_Mouse1.12465701
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12227025
104TP53_18474530_ChIP-ChIP_U2OS_Human1.11355259
105KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11170230
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11033739
107WT1_19549856_ChIP-ChIP_CCG9911_Human1.10130160
108NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09972322
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09972322
110CJUN_26792858_Chip-Seq_BT549_Human1.09790603
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09734720
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.08823118
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08202544
114GF1B_26923725_Chip-Seq_HPCs_Mouse1.07925984
115EP300_21415370_ChIP-Seq_HL-1_Mouse1.07925379
116FUS_26573619_Chip-Seq_HEK293_Human1.05854503
117* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05538805
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05391109
119SMAD3_21741376_ChIP-Seq_HESCs_Human1.05266273
120* TCF4_23295773_ChIP-Seq_U87_Human1.03115496
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02765249
122TRIM28_21343339_ChIP-Seq_HEK293_Human1.02084668
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01048483
124* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00371105
125* RUNX2_22187159_ChIP-Seq_PCA_Human1.00130310
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.98613042
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97362678
128* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96826291
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96569639
130ER_23166858_ChIP-Seq_MCF-7_Human0.95010738
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94699801
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94699801
133RXR_22108803_ChIP-Seq_LS180_Human0.94186040
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.93768777
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93304787
136BCAT_22108803_ChIP-Seq_LS180_Human0.90664496
137KDM2B_26808549_Chip-Seq_K562_Human0.89110837
138SMAD4_21741376_ChIP-Seq_EPCs_Human0.88882537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.69908141
2MP0003880_abnormal_central_pattern4.23405013
3MP0003635_abnormal_synaptic_transmissio3.67089886
4MP0003705_abnormal_hypodermis_morpholog3.32300144
5MP0004270_analgesia3.19921121
6MP0009745_abnormal_behavioral_response3.10201105
7MP0003941_abnormal_skin_development3.09683683
8MP0002064_seizures3.02365344
9MP0009046_muscle_twitch3.00875609
10MP0002063_abnormal_learning/memory/cond2.88750677
11MP0002272_abnormal_nervous_system2.67286338
12MP0000920_abnormal_myelination2.50024475
13MP0002572_abnormal_emotion/affect_behav2.48637023
14MP0001968_abnormal_touch/_nociception2.46191778
15MP0002734_abnormal_mechanical_nocicepti2.42289575
16MP0001440_abnormal_grooming_behavior2.34352198
17MP0001486_abnormal_startle_reflex2.32678093
18MP0003329_amyloid_beta_deposits2.31198136
19MP0000778_abnormal_nervous_system2.26642131
20MP0004145_abnormal_muscle_electrophysio2.26487491
21MP0005423_abnormal_somatic_nervous2.21090737
22MP0005623_abnormal_meninges_morphology2.09958253
23MP0008569_lethality_at_weaning2.08056237
24MP0009780_abnormal_chondrocyte_physiolo2.05788178
25MP0002735_abnormal_chemical_nociception2.00494615
26MP0000428_abnormal_craniofacial_morphol1.96607709
27MP0002184_abnormal_innervation1.96269925
28MP0002067_abnormal_sensory_capabilities1.88333786
29MP0004858_abnormal_nervous_system1.85432735
30MP0003942_abnormal_urinary_system1.82606698
31MP0002736_abnormal_nociception_after1.81754879
32MP0003937_abnormal_limbs/digits/tail_de1.81113011
33MP0002733_abnormal_thermal_nociception1.80936786
34MP0004742_abnormal_vestibular_system1.80644125
35MP0000049_abnormal_middle_ear1.79726482
36MP0001970_abnormal_pain_threshold1.74638481
37MP0002254_reproductive_system_inflammat1.73401348
38MP0000537_abnormal_urethra_morphology1.71763647
39MP0005171_absent_coat_pigmentation1.71463099
40MP0010030_abnormal_orbit_morphology1.71236624
41MP0005508_abnormal_skeleton_morphology1.71000410
42MP0004885_abnormal_endolymph1.70102127
43MP0001501_abnormal_sleep_pattern1.65706075
44MP0000955_abnormal_spinal_cord1.62757884
45MP0001958_emphysema1.62013092
46MP0003690_abnormal_glial_cell1.60291784
47MP0002557_abnormal_social/conspecific_i1.53354106
48MP0009053_abnormal_anal_canal1.53308308
49MP0003279_aneurysm1.52258316
50MP0003634_abnormal_glial_cell1.50239104
51MP0000762_abnormal_tongue_morphology1.48083595
52MP0002882_abnormal_neuron_morphology1.46820857
53MP0002697_abnormal_eye_size1.45235187
54MP0001299_abnormal_eye_distance/1.44530570
55MP0000579_abnormal_nail_morphology1.43717463
56MP0000432_abnormal_head_morphology1.42537096
57MP0002066_abnormal_motor_capabilities/c1.39301776
58MP0003172_abnormal_lysosome_physiology1.38507995
59MP0004142_abnormal_muscle_tone1.38025864
60MP0003119_abnormal_digestive_system1.37414805
61MP0003935_abnormal_craniofacial_develop1.37167911
62MP0003632_abnormal_nervous_system1.37091845
63MP0005386_behavior/neurological_phenoty1.36573922
64MP0004924_abnormal_behavior1.36573922
65MP0004811_abnormal_neuron_physiology1.36555040
66MP0002822_catalepsy1.35148886
67MP0004134_abnormal_chest_morphology1.32919154
68MP0003115_abnormal_respiratory_system1.30122732
69MP0001542_abnormal_bone_strength1.29416514
70MP0010368_abnormal_lymphatic_system1.27786538
71MP0002116_abnormal_craniofacial_bone1.27694793
72MP0003890_abnormal_embryonic-extraembry1.26859880
73MP0002233_abnormal_nose_morphology1.26317272
74MP0001849_ear_inflammation1.25192193
75MP0003136_yellow_coat_color1.21189120
76MP0008438_abnormal_cutaneous_collagen1.20002893
77MP0001529_abnormal_vocalization1.17368127
78MP0002896_abnormal_bone_mineralization1.16875147
79MP0003755_abnormal_palate_morphology1.16324993
80MP0001485_abnormal_pinna_reflex1.16317668
81MP0002932_abnormal_joint_morphology1.16195438
82MP0000604_amyloidosis1.15898028
83MP0002084_abnormal_developmental_patter1.14353883
84MP0001293_anophthalmia1.13357476
85MP0003631_nervous_system_phenotype1.12362537
86MP0001984_abnormal_olfaction1.11776019
87MP0002111_abnormal_tail_morphology1.10341257
88MP0001177_atelectasis1.09559736
89MP0001905_abnormal_dopamine_level1.09488858
90MP0003633_abnormal_nervous_system1.08499429
91MP0010352_gastrointestinal_tract_polyps1.08493565
92MP0003091_abnormal_cell_migration1.07841424
93MP0002085_abnormal_embryonic_tissue1.06600497
94MP0002152_abnormal_brain_morphology1.06029027
95MP0001963_abnormal_hearing_physiology1.03598331
96MP0000751_myopathy1.01034021
97MP0002249_abnormal_larynx_morphology1.00394872
98MP0000733_abnormal_muscle_development1.00093013
99MP0000163_abnormal_cartilage_morphology0.99976054
100MP0000569_abnormal_digit_pigmentation0.99888659
101MP0000013_abnormal_adipose_tissue0.99500022
102MP0002114_abnormal_axial_skeleton0.98647792
103MP0001879_abnormal_lymphatic_vessel0.98156530
104MP0005595_abnormal_vascular_smooth0.97988055
105MP0009384_cardiac_valve_regurgitation0.97823231
106MP0005076_abnormal_cell_differentiation0.96978768
107MP0000767_abnormal_smooth_muscle0.96764878
108MP0006276_abnormal_autonomic_nervous0.96545460
109MP0003566_abnormal_cell_adhesion0.95396127
110MP0004185_abnormal_adipocyte_glucose0.94842718
111MP0004510_myositis0.94249268
112MP0002115_abnormal_skeleton_extremities0.93202726
113MP0002229_neurodegeneration0.92660977
114MP0002060_abnormal_skin_morphology0.91511710
115MP0005257_abnormal_intraocular_pressure0.90883390
116MP0003045_fibrosis0.90423986
117MP0003567_abnormal_fetal_cardiomyocyte0.89403041
118MP0002752_abnormal_somatic_nervous0.88654698
119MP0000383_abnormal_hair_follicle0.87704404
120MP0005503_abnormal_tendon_morphology0.87703194
121MP0002282_abnormal_trachea_morphology0.87392396
122MP0004197_abnormal_fetal_growth/weight/0.86891799
123MP0003879_abnormal_hair_cell0.86791381
124MP0002909_abnormal_adrenal_gland0.86501727
125MP0002081_perinatal_lethality0.85756612
126MP0002109_abnormal_limb_morphology0.85190429
127MP0005187_abnormal_penis_morphology0.84967379
128MP0009672_abnormal_birth_weight0.84236600
129MP0003283_abnormal_digestive_organ0.83562078
130MP0002090_abnormal_vision0.82962771
131MP0001340_abnormal_eyelid_morphology0.82193742
132MP0002177_abnormal_outer_ear0.81667864
133MP0009703_decreased_birth_body0.81608544
134MP0005275_abnormal_skin_tensile0.80533124
135MP0000462_abnormal_digestive_system0.80288905
136MP0003385_abnormal_body_wall0.78483175
137MP0005409_darkened_coat_color0.77922649
138MP0002092_abnormal_eye_morphology0.77475859
139MP0002877_abnormal_melanocyte_morpholog0.75522919
140MP0003787_abnormal_imprinting0.74860108
141MP0001502_abnormal_circadian_rhythm0.74331778
142MP0001286_abnormal_eye_development0.74218402
143MP0005646_abnormal_pituitary_gland0.73200184
144MP0000467_abnormal_esophagus_morphology0.72770984
145MP0000631_abnormal_neuroendocrine_gland0.72554036
146MP0003938_abnormal_ear_development0.72374718
147MP0001346_abnormal_lacrimal_gland0.71039779
148MP0002108_abnormal_muscle_morphology0.70936356
149MP0002069_abnormal_eating/drinking_beha0.70406754
150MP0004272_abnormal_basement_membrane0.67944722
151MP0008874_decreased_physiological_sensi0.67760806
152MP0001348_abnormal_lacrimal_gland0.67176147
153MP0000747_muscle_weakness0.66114943
154MP0000534_abnormal_ureter_morphology0.63761075
155MP0001943_abnormal_respiration0.61626786
156MP0001188_hyperpigmentation0.60958306
157MP0003861_abnormal_nervous_system0.58467726
158MP0002295_abnormal_pulmonary_circulatio0.58120312
159MP0009250_abnormal_appendicular_skeleto0.57230496
160MP0004085_abnormal_heartbeat0.55717807
161MP0002089_abnormal_postnatal_growth/wei0.54847719
162MP0004484_altered_response_of0.54730949

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.07957750
2Action tremor (HP:0002345)5.07086943
3Atonic seizures (HP:0010819)4.80278454
4Myokymia (HP:0002411)4.70099608
5Focal seizures (HP:0007359)4.62267429
6Visual hallucinations (HP:0002367)4.01757898
7Neurofibrillary tangles (HP:0002185)3.96560621
8Supranuclear gaze palsy (HP:0000605)3.74724276
9Premature rupture of membranes (HP:0001788)3.68218541
10Progressive cerebellar ataxia (HP:0002073)3.66719183
11Epileptic encephalopathy (HP:0200134)3.54992691
12Protrusio acetabuli (HP:0003179)3.54272103
13Cerebral inclusion bodies (HP:0100314)3.52781989
14Termporal pattern (HP:0011008)3.43518129
15Insidious onset (HP:0003587)3.43518129
16Intention tremor (HP:0002080)3.36912707
17Dysmetria (HP:0001310)3.32799377
18Dysdiadochokinesis (HP:0002075)3.30945425
19Broad-based gait (HP:0002136)3.28907598
20Absence seizures (HP:0002121)3.20370288
21Scanning speech (HP:0002168)3.18809171
22Febrile seizures (HP:0002373)3.18177938
23Peripheral hypomyelination (HP:0007182)3.16070211
24Abnormality of the corticospinal tract (HP:0002492)3.15493912
25Coronal craniosynostosis (HP:0004440)3.15206652
26Broad metatarsal (HP:0001783)3.07792900
27Gaze-evoked nystagmus (HP:0000640)3.05465625
28Dialeptic seizures (HP:0011146)3.00726419
29Overgrowth (HP:0001548)2.97729041
30Myelomeningocele (HP:0002475)2.87395427
31Degeneration of the lateral corticospinal tracts (HP:0002314)2.86434152
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.86434152
33Short hallux (HP:0010109)2.75072241
34Ulnar claw (HP:0001178)2.71483338
35Septo-optic dysplasia (HP:0100842)2.70711197
36Hyperventilation (HP:0002883)2.67069895
37Vertebral arch anomaly (HP:0008438)2.60634313
38Absent speech (HP:0001344)2.58578728
39Mutism (HP:0002300)2.58271376
40Generalized tonic-clonic seizures (HP:0002069)2.55102423
41Genu recurvatum (HP:0002816)2.54060865
42Akinesia (HP:0002304)2.53995889
43Soft skin (HP:0000977)2.52119440
44Diplopia (HP:0000651)2.52078630
45Abnormality of binocular vision (HP:0011514)2.52078630
46Aplasia/Hypoplasia of the hallux (HP:0008362)2.49871182
47Spastic gait (HP:0002064)2.49065806
48Abnormality of the middle phalanges of the toes (HP:0010183)2.42487322
49Ankle clonus (HP:0011448)2.42195593
50Abnormality of dentin (HP:0010299)2.39124522
51Ankle contracture (HP:0006466)2.38650664
52Bladder diverticulum (HP:0000015)2.38219472
53Aortic regurgitation (HP:0001659)2.36020413
54Excessive salivation (HP:0003781)2.35563712
55Drooling (HP:0002307)2.35563712
56Truncal ataxia (HP:0002078)2.34405848
57Cutaneous finger syndactyly (HP:0010554)2.31794454
58Epiphyseal dysplasia (HP:0002656)2.30026197
59Postural tremor (HP:0002174)2.29907047
60Sensory axonal neuropathy (HP:0003390)2.28810941
61Depression (HP:0000716)2.26863553
62Turricephaly (HP:0000262)2.24174392
63Cutaneous syndactyly (HP:0012725)2.23528633
64Abnormal eating behavior (HP:0100738)2.22659831
65Aortic dissection (HP:0002647)2.21370777
66Neonatal short-limb short stature (HP:0008921)2.21102363
67Choanal stenosis (HP:0000452)2.20513259
68Morphological abnormality of the middle ear (HP:0008609)2.19947159
69Aqueductal stenosis (HP:0002410)2.18493962
70Preaxial foot polydactyly (HP:0001841)2.17254020
71Impaired vibration sensation in the lower limbs (HP:0002166)2.17177061
72Arterial tortuosity (HP:0005116)2.17050696
73Lower limb asymmetry (HP:0100559)2.16384415
74Mesomelia (HP:0003027)2.16243971
75Onion bulb formation (HP:0003383)2.15599400
76Bell-shaped thorax (HP:0001591)2.13816273
77Abnormality of the ischium (HP:0003174)2.13737244
78Deep palmar crease (HP:0006191)2.13614418
79Atrophic scars (HP:0001075)2.12942767
80Impaired social interactions (HP:0000735)2.11036804
81Abnormal social behavior (HP:0012433)2.11036804
82Megalencephaly (HP:0001355)2.09382748
83Aplasia involving bones of the extremities (HP:0009825)2.08015136
84Aplasia involving bones of the upper limbs (HP:0009823)2.08015136
85Aplasia of the phalanges of the hand (HP:0009802)2.08015136
86Generalized myoclonic seizures (HP:0002123)2.06827917
87Persistence of primary teeth (HP:0006335)2.06663957
88Mitral valve prolapse (HP:0001634)2.06259874
89Amblyopia (HP:0000646)2.05761090
90Fetal akinesia sequence (HP:0001989)2.05639383
91Broad long bones (HP:0005622)2.05479148
92Progressive inability to walk (HP:0002505)2.04588683
93Anomalous pulmonary venous return (HP:0010772)2.04131586
94Synostosis of carpal bones (HP:0005048)2.03907300
95Vascular tortuosity (HP:0004948)2.03713866
96Broad ribs (HP:0000885)2.03628657
97Poor eye contact (HP:0000817)2.03615351
98Hemiparesis (HP:0001269)2.03128151
99Aortic aneurysm (HP:0004942)2.02007904
100Relative macrocephaly (HP:0004482)2.01561354
101Postural instability (HP:0002172)1.99879262
102Anxiety (HP:0000739)1.99622700
103Arnold-Chiari malformation (HP:0002308)1.99033438
104Neuronal loss in central nervous system (HP:0002529)1.98801622
105Gait ataxia (HP:0002066)1.98586559
106Premature skin wrinkling (HP:0100678)1.96655843
107Abnormality of the pulmonary veins (HP:0011718)1.96462451
108Spastic diplegia (HP:0001264)1.94985169
109Hammertoe (HP:0001765)1.93501662
110Blue irides (HP:0000635)1.93228648
111Ectopia lentis (HP:0001083)1.92367068
112Alacrima (HP:0000522)1.91125735
113Carpal synostosis (HP:0009702)1.90766023
114Bowel diverticulosis (HP:0005222)1.90218523
115Impaired smooth pursuit (HP:0007772)1.89631028
116Wide anterior fontanel (HP:0000260)1.89439641
117Obstructive sleep apnea (HP:0002870)1.89028839
118Syringomyelia (HP:0003396)1.88213817
119Spinal cord lesions (HP:0100561)1.88213817
120Abnormality of the lower motor neuron (HP:0002366)1.87636830
121Stereotypic behavior (HP:0000733)1.86796710
122Shallow orbits (HP:0000586)1.86329057
123Deviation of the hallux (HP:0010051)1.85915434
124Hypoplasia of the iris (HP:0007676)1.85777661
125Absent toe (HP:0010760)1.84806896
126Biconcave vertebral bodies (HP:0004586)1.84655105
127Urinary bladder sphincter dysfunction (HP:0002839)1.84625186
128Lower limb muscle weakness (HP:0007340)1.83922912
129Wormian bones (HP:0002645)1.82925201
130Short 4th metacarpal (HP:0010044)1.82361067
131Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82361067
132Abnormality of the parathyroid morphology (HP:0011766)1.82077934
133Omphalocele (HP:0001539)1.81173394
134Mild short stature (HP:0003502)1.79367077
135Scapular winging (HP:0003691)1.78979557
136Abnormality of ocular smooth pursuit (HP:0000617)1.78573947
137Thickened helices (HP:0000391)1.78477936
138Hemiplegia (HP:0002301)1.78083152
139Hyperextensible skin (HP:0000974)1.76273090
140Papilledema (HP:0001085)1.76009594
141Genetic anticipation (HP:0003743)1.75692645
142Amyotrophic lateral sclerosis (HP:0007354)1.75275850
143Abnormality of the 4th metacarpal (HP:0010012)1.74788554
144Urethral obstruction (HP:0000796)1.74179483
145Abnormality of salivation (HP:0100755)1.73770521
146Small epiphyses (HP:0010585)1.73613213
147Vitreoretinal degeneration (HP:0000655)1.71959517
148Widely spaced teeth (HP:0000687)1.71936690
149Broad phalanx (HP:0006009)1.71178923
150Microglossia (HP:0000171)1.71174208
151Ankyloglossia (HP:0010296)1.70992152
152Slow progression (HP:0003677)1.70296232
153Clumsiness (HP:0002312)1.68612481
154Increased variability in muscle fiber diameter (HP:0003557)1.67804050
155Absent frontal sinuses (HP:0002688)1.67134716
156Abnormality of the phalanges of the hallux (HP:0010057)1.66352217
157Epileptiform EEG discharges (HP:0011182)1.66297201
158Urinary urgency (HP:0000012)1.66060985
159Rapidly progressive (HP:0003678)1.65649787
160Steppage gait (HP:0003376)1.65568838
161Hallux valgus (HP:0001822)1.65207585
162Pulmonic stenosis (HP:0001642)1.64694342
163Hypoplastic ischia (HP:0003175)1.64259735
164Abnormality of the phalanges of the 2nd finger (HP:0009541)1.63936586
165Abnormality of the epiphyses of the hand (HP:0005924)1.62277409
166Fibular hypoplasia (HP:0003038)1.61203227
167Embryonal renal neoplasm (HP:0011794)1.60909710
168Blue sclerae (HP:0000592)1.60629609
169Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.58984522
170Dental crowding (HP:0000678)1.58909250
171Camptodactyly of toe (HP:0001836)1.57791464
1722-3 toe syndactyly (HP:0004691)1.56996348
173Missing ribs (HP:0000921)1.56028036
174Cortical dysplasia (HP:0002539)1.55177106
175Synostosis involving bones of the lower limbs (HP:0009138)1.54906805
176Synostosis involving bones of the feet (HP:0009140)1.54906805
177Abnormality of the distal phalanx of the thumb (HP:0009617)1.53842431
178Keratoconus (HP:0000563)1.53630890
179Increased corneal curvature (HP:0100692)1.53630890
180Asymmetry of the thorax (HP:0001555)1.53508386
181Mitral regurgitation (HP:0001653)1.53451295
182Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.53022387
183Fibular aplasia (HP:0002990)1.53002643
184Bifid tongue (HP:0010297)1.52580137
185Broad thumb (HP:0011304)1.52348710
186Abnormality of the 2nd finger (HP:0004100)1.51785099
187Spinal rigidity (HP:0003306)1.50808142

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYRO34.20145387
2TAF13.87424872
3NTRK33.66807671
4EPHA43.40091638
5FES3.23935389
6CASK2.65836839
7TNIK2.51299324
8MARK12.34846721
9MAP3K92.33168233
10NTRK12.21722835
11MINK12.15832767
12EPHB12.15585828
13MAP3K42.02954707
14PRPF4B2.02660732
15MAP3K101.94203462
16PAK61.93859144
17LATS11.91401953
18STK391.90305518
19NTRK21.89945588
20RIPK11.88315434
21KSR21.80398297
22CDK121.72590811
23MAP3K21.68347675
24SGK21.58597915
25STK38L1.51275517
26OXSR11.48738903
27BRD41.43853984
28MAPK131.39618357
29RIPK41.39205747
30PLK21.38266769
31UHMK11.35791063
32CDK51.32195340
33MKNK11.30519838
34TTK1.30064963
35PKN11.29235262
36LIMK11.29079881
37NEK91.28936835
38PRKD31.26132981
39SGK31.24958726
40CAMKK11.24183908
41MKNK21.23053258
42MAP2K71.22747263
43CAMKK21.22036891
44EEF2K1.21839401
45ICK1.21296133
46DDR21.20765121
47WNK11.19779066
48ROCK21.19403111
49KSR11.18491264
50MOS1.17675988
51SMG11.17581123
52EPHB21.14715311
53DAPK21.13949293
54PDGFRB1.13939255
55PNCK1.09514065
56RET1.08705978
57TSSK61.08046436
58MAP2K41.04354274
59CDK191.03215815
60STK241.02027690
61PAK21.02007156
62STK31.01796048
63CDC71.01382995
64AKT30.99832377
65NEK60.99126165
66PRKCH0.98205144
67FGFR10.97986828
68PRKCG0.97984142
69MARK20.97570795
70CAMK2B0.95572535
71CAMK2A0.93365552
72FGFR20.92691139
73FGR0.92523809
74LATS20.92058531
75IRAK20.89360349
76PHKG20.87776507
77PHKG10.87776507
78PAK30.85870385
79MET0.83801722
80GRK50.83260248
81FYN0.82224338
82DMPK0.81204957
83PLK30.80356601
84SGK2230.80164760
85SGK4940.80164760
86CDK140.79552909
87TRIB30.78349393
88CAMK1G0.78058985
89NLK0.77532288
90BMPR20.75886199
91PTK2B0.75819303
92TGFBR10.73735386
93TIE10.73424160
94BMPR1B0.72929533
95YES10.72724115
96ROCK10.72309705
97CDK150.71659257
98CDK180.70867995
99MAP3K130.70727522
100CAMK1D0.69241423
101WNK40.68403089
102PTK20.68323711
103SIK20.68044522
104CAMK2D0.67645841
105STK380.67503797
106STK110.67033140
107PRKCE0.66787954
108MAPK70.63882892
109EPHA30.61585431
110MTOR0.60598618
111FER0.60588203
112MELK0.60428986
113IRAK10.60232707
114CDK11A0.59709678
115INSR0.58889622
116CSK0.58468097
117PBK0.57830634
118SGK10.57649998
119NME10.57507359
120PDK10.56949850
121BCR0.55079725
122DYRK20.55017008
123CAMK2G0.54581925
124BMX0.54267937
125PDPK10.54128006
126PRKCQ0.54081685
127RAF10.53813444
128ALK0.53447229
129ARAF0.52995467
130PAK40.52514032
131RPS6KA20.52192440
132MAPKAPK50.50306546
133CHEK20.48869794
134DYRK1A0.47157742
135SRC0.46807929
136CSNK1G10.46268662
137CSNK1G20.45800002
138CAMK10.44129325
139PDGFRA0.43449074
140RPS6KB10.43324893
141CSNK1D0.41835745
142RPS6KA30.41543438
143MAPK100.41190140
144ERBB40.40039624
145CDC42BPA0.39915276
146MYLK0.39111205
147ERBB20.37630480
148MAP3K10.36161971
149EIF2AK20.34080804
150ADRBK10.33972171
151RPS6KL10.33330890
152RPS6KC10.33330890
153CDK90.31997869
154SRPK10.31996958
155PRKDC0.31740434

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.00107336
2Glutamatergic synapse_Homo sapiens_hsa047242.53207048
3Long-term potentiation_Homo sapiens_hsa047202.45044341
4Synaptic vesicle cycle_Homo sapiens_hsa047212.33553882
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33017307
6Adherens junction_Homo sapiens_hsa045202.31124702
7Basal cell carcinoma_Homo sapiens_hsa052172.23344463
8GABAergic synapse_Homo sapiens_hsa047272.15225956
9Hippo signaling pathway_Homo sapiens_hsa043902.14136399
10Circadian entrainment_Homo sapiens_hsa047132.14052949
11Hedgehog signaling pathway_Homo sapiens_hsa043402.02455325
12Long-term depression_Homo sapiens_hsa047302.01698520
13Morphine addiction_Homo sapiens_hsa050321.97115139
14Cholinergic synapse_Homo sapiens_hsa047251.94339013
15Salivary secretion_Homo sapiens_hsa049701.92801830
16Amphetamine addiction_Homo sapiens_hsa050311.86365799
17MicroRNAs in cancer_Homo sapiens_hsa052061.83978868
18Dopaminergic synapse_Homo sapiens_hsa047281.78193000
19Axon guidance_Homo sapiens_hsa043601.78060434
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76638086
21Olfactory transduction_Homo sapiens_hsa047401.75682347
22TGF-beta signaling pathway_Homo sapiens_hsa043501.63831340
23Gastric acid secretion_Homo sapiens_hsa049711.63454558
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.60588210
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.56891078
26Serotonergic synapse_Homo sapiens_hsa047261.54084176
27Melanoma_Homo sapiens_hsa052181.54018839
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.51636657
29Oxytocin signaling pathway_Homo sapiens_hsa049211.48828113
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47801517
31Taste transduction_Homo sapiens_hsa047421.44806182
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.41643060
33Renin secretion_Homo sapiens_hsa049241.39665947
34GnRH signaling pathway_Homo sapiens_hsa049121.38106596
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36933156
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36517198
37Collecting duct acid secretion_Homo sapiens_hsa049661.36422404
38Insulin secretion_Homo sapiens_hsa049111.32622388
39Prostate cancer_Homo sapiens_hsa052151.31759097
40Calcium signaling pathway_Homo sapiens_hsa040201.31203039
41Glioma_Homo sapiens_hsa052141.23011115
42Colorectal cancer_Homo sapiens_hsa052101.22473161
43Gap junction_Homo sapiens_hsa045401.22422267
44Small cell lung cancer_Homo sapiens_hsa052221.22314599
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20274808
46Estrogen signaling pathway_Homo sapiens_hsa049151.19341481
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.18694586
48Notch signaling pathway_Homo sapiens_hsa043301.16885094
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16277105
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14293486
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13740639
52ErbB signaling pathway_Homo sapiens_hsa040121.13139366
53cAMP signaling pathway_Homo sapiens_hsa040241.10215324
54Type II diabetes mellitus_Homo sapiens_hsa049301.09642621
55Cocaine addiction_Homo sapiens_hsa050301.07441696
56Pathways in cancer_Homo sapiens_hsa052001.06775601
57Central carbon metabolism in cancer_Homo sapiens_hsa052301.06289874
58Choline metabolism in cancer_Homo sapiens_hsa052311.02685857
59PI3K-Akt signaling pathway_Homo sapiens_hsa041511.02467891
60Thyroid cancer_Homo sapiens_hsa052161.02343280
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01770868
62Vascular smooth muscle contraction_Homo sapiens_hsa042701.00063864
63Vibrio cholerae infection_Homo sapiens_hsa051100.97529267
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96589158
65Chronic myeloid leukemia_Homo sapiens_hsa052200.96557353
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96355750
67Dorso-ventral axis formation_Homo sapiens_hsa043200.94599330
68Pancreatic secretion_Homo sapiens_hsa049720.94169073
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94080931
70Melanogenesis_Homo sapiens_hsa049160.93236308
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.92350923
72mRNA surveillance pathway_Homo sapiens_hsa030150.89823434
73Prion diseases_Homo sapiens_hsa050200.89802278
74Renal cell carcinoma_Homo sapiens_hsa052110.89446483
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89122198
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85617152
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85096720
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84924752
79Selenocompound metabolism_Homo sapiens_hsa004500.84068703
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83264243
81VEGF signaling pathway_Homo sapiens_hsa043700.82641125
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82563030
83Thyroid hormone synthesis_Homo sapiens_hsa049180.79545181
84Bladder cancer_Homo sapiens_hsa052190.79134365
85Ether lipid metabolism_Homo sapiens_hsa005650.78093928
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77506845
87Dilated cardiomyopathy_Homo sapiens_hsa054140.75540961
88Cell cycle_Homo sapiens_hsa041100.74509861
89Ras signaling pathway_Homo sapiens_hsa040140.73442550
90ECM-receptor interaction_Homo sapiens_hsa045120.72713944
91Endocytosis_Homo sapiens_hsa041440.71835198
92Focal adhesion_Homo sapiens_hsa045100.71133021
93Alcoholism_Homo sapiens_hsa050340.71067786
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71023490
95MAPK signaling pathway_Homo sapiens_hsa040100.69781787
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68547703
97Rap1 signaling pathway_Homo sapiens_hsa040150.66306222
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65920988
99Platelet activation_Homo sapiens_hsa046110.64971446
100RNA transport_Homo sapiens_hsa030130.64049676
101Prolactin signaling pathway_Homo sapiens_hsa049170.62921951
102Sphingolipid metabolism_Homo sapiens_hsa006000.62833060
103Lysine degradation_Homo sapiens_hsa003100.62180918
104p53 signaling pathway_Homo sapiens_hsa041150.61955250
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61751197
106Steroid biosynthesis_Homo sapiens_hsa001000.60516864
107Basal transcription factors_Homo sapiens_hsa030220.60480285
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59795348
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59655344
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59224800
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58480237
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.58430583
113Endometrial cancer_Homo sapiens_hsa052130.57316742
114Cardiac muscle contraction_Homo sapiens_hsa042600.56102528
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55101140
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54675814
117T cell receptor signaling pathway_Homo sapiens_hsa046600.54504781
118Oocyte meiosis_Homo sapiens_hsa041140.53521663
119* Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53364037
120Ovarian steroidogenesis_Homo sapiens_hsa049130.53338255
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52871207
122mTOR signaling pathway_Homo sapiens_hsa041500.52818316
123Tight junction_Homo sapiens_hsa045300.52062575
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51281685
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49675589
126Amoebiasis_Homo sapiens_hsa051460.48571301
127Proteoglycans in cancer_Homo sapiens_hsa052050.48311425
128Non-small cell lung cancer_Homo sapiens_hsa052230.46601411
129Wnt signaling pathway_Homo sapiens_hsa043100.46511375
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46031934
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45364635
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45238222
133Chemokine signaling pathway_Homo sapiens_hsa040620.45184235
134Protein digestion and absorption_Homo sapiens_hsa049740.43123501
135Inositol phosphate metabolism_Homo sapiens_hsa005620.42401483

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